TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
ko04916	Melanogenesis	3.27806141656904e-05	-10.325673248836	101	100	0.0158730158730159	6300	7161	7483,7482,2776,10488,8325,5568,5331,4286,5894,91860,2771,1387,817,5443,80326,3845,7478,1499,111,8324,4893,89780,1638,7480,6932,7477,2535,51806,815,54361,5605,5594,805,7479,64764,810,3815,808,5567,163688,11211,1857,90993,818,8326,7473,7472,2033,114,8321,4254,5595,5604,23236,3265,5582,7299,801,1855,81029,112,84699,434,7474,1906,7481,107,6934,5332,7475,816,2932,7306,1910,5578,2773,7855,4157,83439,7476,5579,8323,51176,8322,7471,196883,51384,108,113,148327,115,1385,5566,7484,1856,109,5330,7976,2770,2778	WNT9A,WNT2B,GNAQ,CREB3,FZD8,PRKACG,PLCB3,MITF,RAF1,CALML4,GNAI2,CREBBP,CAMK2D,POMC,WNT10A,KRAS,WNT8A,CTNNB1,ADCY5,FZD7,NRAS,WNT3A,DCT,WNT10B,TCF7,WNT7B,FZD2,CALML5,CAMK2A,WNT4,MAP2K2,MAPK1,CALM2,WNT8B,CREB3L2,CALML3,KIT,CALM3,PRKACB,CALML6,FZD10,DVL3,CREB3L1,CAMK2G,FZD9,WNT3,WNT2,EP300,ADCY8,FZD1,KITLG,MAPK3,MAP2K1,PLCB1,HRAS,PRKCG,TYR,CALM1,DVL1,WNT5B,ADCY6,CREB3L3,ASIP,WNT5A,EDN1,WNT11,ADCY1,TCF7L2,PLCB4,WNT6,CAMK2B,GSK3B,TYRP1,EDNRB,PRKCA,GNAI3,FZD5,MC1R,TCF7L1,WNT7A,PRKCB,FZD6,LEF1,FZD4,WNT1,ADCY4,WNT16,ADCY2,ADCY7,CREB3L4,ADCY9,CREB1,PRKACA,WNT9B,DVL2,ADCY3,PLCB2,FZD3,GNAI1,GNAS
hsa04916	Melanogenesis	3.27806141656904e-05	-10.325673248836	101	100	0.0158730158730159	6300	7161	23236,3265,7299,801,5582,81029,112,1855,7474,84699,434,7481,1906,107,6934,2932,816,7306,5332,7475,7855,1910,5578,2773,7476,4157,83439,196883,7471,5579,8323,51176,8322,108,51384,113,148327,5566,7484,1856,109,115,1385,5330,7976,2770,2778,2776,7483,7482,5331,8325,10488,5568,91860,2771,1387,817,4286,5894,80326,5443,3845,1499,7478,111,8324,7477,2535,4893,1638,89780,7480,6932,51806,54361,5594,5605,815,64764,805,7479,163688,808,5567,11211,1857,810,3815,818,8326,90993,8321,4254,7473,7472,114,2033,5604,5595	PLCB1,HRAS,TYR,CALM1,PRKCG,WNT5B,ADCY6,DVL1,WNT5A,CREB3L3,ASIP,WNT11,EDN1,ADCY1,TCF7L2,GSK3B,CAMK2B,TYRP1,PLCB4,WNT6,FZD5,EDNRB,PRKCA,GNAI3,WNT7A,MC1R,TCF7L1,ADCY4,WNT1,PRKCB,FZD6,LEF1,FZD4,ADCY2,WNT16,ADCY7,CREB3L4,PRKACA,WNT9B,DVL2,ADCY3,ADCY9,CREB1,PLCB2,FZD3,GNAI1,GNAS,GNAQ,WNT9A,WNT2B,PLCB3,FZD8,CREB3,PRKACG,CALML4,GNAI2,CREBBP,CAMK2D,MITF,RAF1,WNT10A,POMC,KRAS,CTNNB1,WNT8A,ADCY5,FZD7,WNT7B,FZD2,NRAS,DCT,WNT3A,WNT10B,TCF7,CALML5,WNT4,MAPK1,MAP2K2,CAMK2A,CREB3L2,CALM2,WNT8B,CALML6,CALM3,PRKACB,FZD10,DVL3,CALML3,KIT,CAMK2G,FZD9,CREB3L1,FZD1,KITLG,WNT3,WNT2,ADCY8,EP300,MAP2K1,MAPK3
hsa05200	Pathways in cancer	8.45160283625848e-05	-9.37856935682471	395	370	0.0587301587301587	6300	7161	4254,841,10235,7473,6387,7852,5595,1857,5159,54205,3815,5731,5881,596,5605,22798,2250,2791,6256,2535,7477,7423,7480,57449,4149,1147,3480,4790,387,2259,207,581,5293,3845,5734,1019,5331,6688,1902,2771,2776,5336,11186,8817,3082,2323,2793,8031,54583,8900,7039,4089,623,109,1856,7471,2255,5579,10161,842,5899,3912,5733,10928,26060,7476,7849,2932,2260,5898,1029,998,2773,5578,112399,2113,1436,107,7424,354,3066,7704,5599,5296,7474,5879,4318,5291,5337,595,5155,4088,2788,8321,2033,4792,8313,3728,3091,3673,8326,861,5467,3688,54361,1284,7043,332,7175,2335,6772,1499,1909,9826,355,51684,8324,2735,2885,9475,5925,80326,2767,94235,5568,2252,3915,6608,1487,2956,1286,7482,3320,652,9138,675,4609,2475,5728,3569,2308,867,3725,113,5979,7046,10342,27148,1164,54331,3685,23365,356,25,8323,51176,4312,1495,1612,7187,862,10297,7170,2782,2248,112401,7855,1871,898,2249,6934,1050,5602,1956,5915,3910,3918,2034,112398,83593,2353,6654,5970,3674,2064,624,7472,1285,3911,5747,5567,1950,1488,55970,5371,2768,5743,1870,2736,23566,7422,1630,4893,6502,2246,29119,3914,7185,3716,1441,8643,8325,10681,5468,7040,7048,115727,4286,673,2122,3326,7976,8074,27006,2322,405,2271,2950,2792,5566,115,196883,10672,4824,3913,51384,10125,7189,5732,2737,5332,7188,598,2247,5914,23624,3675,9134,1030,1496,6655,9965,64399,6513,9063,8453,8822,8503,3551,613,3265,868,5727,5582,2786,114,5335,8312,3908,5604,6777,11211,51764,5290,5594,3479,2261,7042,25780,7479,185,1398,650,6932,57121,836,10000,89780,208,1021,5601,7478,6923,324,111,2784,2257,284217,1026,6789,3909,2253,5228,8030,1387,5894,7428,7483,330,1017,4914,2263,5156,5900,4193,5330,6776,2787,2254,4087,23604,7157,2778,26281,2770,5295,7484,3655,3065,4791,8322,4313,108,1613,2149,83439,2783,3576,2251,7475,6469,4436,10319,2790,1282,1910,329,7481,5154,6258,1027,6774,2256,79444,4292,4233,6921,112,8772,81029,26291,1855,1869,9915,9978,5880,5888,23236,59345,999	KITLG,CASP8,RASGRP2,WNT3,CXCL12,CXCR4,MAPK3,DVL3,PDGFRB,CYCS,KIT,PTGER1,RAC3,BCL2,MAP2K2,LAMB4,FGF5,GNG11,RXRA,FZD2,WNT7B,VEGFB,WNT10B,PLEKHG5,MAX,CHUK,IGF1R,NFKB1,RHOA,FGF14,AKT1,BAX,PIK3CD,KRAS,PTGER4,CDK4,PLCB3,SPI1,LPAR1,GNAI2,GNAQ,PLCG2,RASSF1,FGF18,HGF,FLT3LG,GNGT2,NCOA4,EGLN1,CCNA1,TGFA,SMAD4,BDKRB1,ADCY3,DVL2,WNT1,FGF10,PRKCB,LPAR6,CASP9,RALB,LAMB1,PTGER3,RALBP1,APPL1,WNT7A,PAX8,GSK3B,FGFR1,RALA,CDKN2A,CDC42,GNAI3,PRKCA,EGLN3,ETS1,CSF1R,ADCY1,VEGFC,KLK3,HDAC2,ZBTB16,MAPK8,PIK3R2,WNT5A,RAC1,MMP9,PIK3CB,PLD1,CCND1,PDGFB,SMAD3,GNG7,FZD1,EP300,NFKBIA,AXIN2,JUP,HIF1A,ITGA2,FZD9,RUNX1,PPARD,ITGB1,WNT4,COL4A2,TGFB3,BIRC5,TPR,FN1,STAT1,CTNNB1,EDNRA,ARHGEF11,FAS,SUFU,FZD7,GLI1,GRB2,ROCK2,RB1,WNT10A,GNA11,GNG8,PRKACG,FGF7,LAMC1,SMO,CTBP1,MSH6,COL4A4,WNT2B,HSP90AA1,BMP4,ARHGEF1,BRCA2,MYC,MTOR,PTEN,IL6,FOXO1,CBL,JUN,ADCY7,RET,TGFBR1,TFG,STK36,CKS2,GNG2,ITGAV,ARHGEF12,FASLG,ABL1,FZD6,LEF1,MMP1,CTNNA1,DAPK1,TRAF3,RUNX1T1,APC2,TPM3,GNB1,FGF3,BIRC8,FZD5,E2F3,CCNE1,FGF4,TCF7L2,CEBPA,MAPK10,EGFR,RARB,LAMA4,LAMC2,EPAS1,EGLN2,RASSF5,FOS,SOS1,RELA,ITGA2B,ERBB2,BDKRB2,WNT2,COL4A3,LAMA5,PTK2,PRKACB,EGF,CTBP2,GNG12,PML,GNA12,PTGS2,E2F2,GLI2,LPAR3,VEGFA,DCC,NRAS,SKP2,FGF1,CTNNA3,LAMB3,TRAF1,JAK1,CSF3R,PTCH2,FZD8,GNB5,PPARG,TGFB1,TGFBR2,RASGRP4,MITF,BRAF,MECOM,HSP90AB1,FZD3,FGF23,FGF22,FLT3,ARNT,FH,GSTP1,GNGT1,PRKACA,ADCY9,ADCY4,GNA13,NKX3-1,LAMB2,WNT16,RASGRP1,TRAF6,PTGER2,GLI3,PLCB4,TRAF5,BCL2L1,FGF2,RARA,CBLC,ITGA3,CCNE2,CDKN2B,CTNNA2,SOS2,FGF19,HHIP,SLC2A1,PIAS2,CUL2,FGF17,PIK3R3,IKBKB,BCR,HRAS,CBLB,PTCH1,PRKCG,GNG4,ADCY8,PLCG1,AXIN1,LAMA2,MAP2K1,STAT5B,FZD10,GNG13,PIK3CA,MAPK1,IGF1,FGFR3,TGFB2,RASGRP3,WNT8B,AGTR1,CRK,BMP2,TCF7,LPAR5,CASP3,AKT3,WNT3A,AKT2,CDK6,MAPK9,WNT8A,ELOB,APC,ADCY5,GNB3,FGF12,LAMA1,CDKN1A,STK4,LAMA3,FGF8,PGF,CCDC6,CREBBP,RAF1,VHL,WNT9A,BIRC3,CDK2,NTRK1,FGFR2,PDGFRA,RALGDS,MDM2,PLCB2,STAT5A,GNG5,FGF9,SMAD2,DAPK2,TP53,GNAS,FGF20,GNAI1,PIK3R1,WNT9B,ITGA6,HDAC1,NFKB2,FZD4,MMP2,ADCY2,DAPK3,F2R,TCF7L1,GNB2,CXCL8,FGF6,WNT6,SHH,MSH2,LAMC3,GNG10,COL4A1,EDNRB,BIRC2,WNT11,PDGFA,RXRG,CDKN1B,STAT3,FGF11,BIRC7,MLH1,MET,ELOC,ADCY6,FADD,WNT5B,FGF21,DVL1,E2F1,ARNT2,RBX1,RAC2,RAD51,PLCB1,GNB4,CDH1
hsa04371	Apelin signaling pathway	0.000119639450706746	-9.0310279154305	138	134	0.0212698412698413	6300	7161	6547,10672,3710,196883,4842,6237,4635,108,59,6696,2782,2783,814,5294,146850,6198,4634,5330,5327,2793,2792,2770,2787,4087,7046,4089,30849,6543,113,11345,4208,115,54331,109,5566,9759,5565,11337,8877,5140,112,5346,4207,23533,4209,59345,3265,23236,4088,2788,801,999,595,5332,53632,23710,22800,8678,2773,2790,10365,5564,10014,10891,4854,3991,6261,6548,6199,5054,340156,107,5563,5562,55970,5594,100271849,5605,56848,185,6546,805,4638,3709,1490,5571,2791,10000,4893,91807,208,51806,22808,114,55811,2786,7350,5604,5595,3714,6194,810,5567,163688,808,51764,4899,4205,4846,1958,85366,5568,10681,187,5331,5894,2771,91860,4633,6263,6262,2776,2475,3708,207,5289,51422,7019,111,2784,182,3845,94235,5581	SLC8A3,GNA13,ITPR3,ADCY4,NOS1,RRAS,MYL4,ADCY2,ACTA2,SPP1,GNB1,GNB2,CAMK4,PIK3CG,PIK3R6,RPS6KB1,MYL3,PLCB2,PLAT,GNGT2,GNGT1,GNAI1,GNG5,SMAD2,TGFBR1,SMAD4,PIK3R4,SLC8A2,ADCY7,GABARAPL2,MEF2C,ADCY9,GNG2,ADCY3,PRKACA,HDAC4,PRKAB2,GABARAP,SPHK1,PDE3B,ADCY6,PLIN1,BORCS8-MEF2B,PIK3R5,MEF2D,GNB4,HRAS,PLCB1,SMAD3,GNG7,CALM1,CDH1,CCND1,PLCB4,PRKAG3,GABARAPL1,RRAS2,BECN1,GNAI3,GNG10,KLF2,PRKAB1,HDAC5,PPARGC1A,NOTCH3,LIPE,RYR1,SLC9A1,RPS6KB2,SERPINE1,MYLK4,ADCY1,PRKAA2,PRKAA1,GNG12,MAPK1,MEF2B,MAP2K2,SPHK2,AGTR1,SLC8A1,CALM2,MYLK,ITPR2,CCN2,PRKAG1,GNG11,AKT3,NRAS,MYLK3,AKT2,CALML5,MRAS,ADCY8,ADCY10,GNG4,UCP1,MAP2K1,MAPK3,JAG2,RPS6,CALML3,PRKACB,CALML6,CALM3,GNG13,NRF1,MEF2A,NOS3,EGR1,MYLK2,PRKACG,GNB5,APLNR,PLCB3,RAF1,GNAI2,CALML4,MYL2,RYR3,RYR2,GNAQ,MTOR,ITPR1,AKT1,PIK3C3,PRKAG2,TFAM,ADCY5,GNB3,JAG1,KRAS,GNG8,PRKCE
hsa04917	Prolactin signaling pathway	0.000121765778427353	-9.01341120745928	70	70	0.0111111111111111	6300	7161	2099,53358,8792,5594,5605,5600,208,6772,4893,2645,10000,5617,8600,3972,6514,3973,6777,25759,5595,5604,6464,1081,6776,9655,2001,5295,5290,3630,5894,2309,399694,5296,1586,1432,5599,8651,5602,5603,8503,9021,5970,1154,595,30837,6654,2353,3659,6300,894,2100,5291,2592,3265,2885,6714,207,1447,9306,5618,5601,4790,2932,7054,3845,6655,5293,6774,122809,3717,8835	ESR1,SHC3,TNFRSF11A,MAPK1,MAP2K2,MAPK11,AKT2,STAT1,NRAS,GCK,AKT3,PRL,TNFSF11,LHB,SLC2A2,LHCGR,STAT5B,SHC2,MAPK3,MAP2K1,SHC1,CGA,STAT5A,SOCS5,ELF5,PIK3R1,PIK3CA,INS,RAF1,FOXO3,SHC4,PIK3R2,CYP17A1,MAPK14,MAPK8,SOCS1,MAPK10,MAPK13,PIK3R3,SOCS3,RELA,CISH,CCND1,SOCS7,SOS1,FOS,IRF1,MAPK12,CCND2,ESR2,PIK3CB,GALT,HRAS,GRB2,SRC,AKT1,CSN2,SOCS6,PRLR,MAPK9,NFKB1,GSK3B,TH,KRAS,SOS2,PIK3CD,STAT3,SOCS4,JAK2,SOCS2
ko04917	Prolactin signaling pathway	0.000121765778427353	-9.01341120745928	70	70	0.0111111111111111	6300	7161	9021,8503,5603,5602,8651,5599,1432,1586,399694,5296,5894,2309,3265,2592,5291,2100,6300,894,3659,2353,6654,30837,595,1154,5970,2932,4790,5601,5618,9306,1447,207,6714,2885,8835,3717,122809,5293,6774,6655,3845,7054,5600,5594,5605,8792,53358,2099,3973,6514,3972,8600,5617,10000,2645,4893,6772,208,6776,1081,6464,5595,5604,25759,6777,3630,5290,5295,2001,9655	SOCS3,PIK3R3,MAPK13,MAPK10,SOCS1,MAPK8,MAPK14,CYP17A1,SHC4,PIK3R2,RAF1,FOXO3,HRAS,GALT,PIK3CB,ESR2,MAPK12,CCND2,IRF1,FOS,SOS1,SOCS7,CCND1,CISH,RELA,GSK3B,NFKB1,MAPK9,PRLR,SOCS6,CSN2,AKT1,SRC,GRB2,SOCS2,JAK2,SOCS4,PIK3CD,STAT3,SOS2,KRAS,TH,MAPK11,MAPK1,MAP2K2,TNFRSF11A,SHC3,ESR1,LHCGR,SLC2A2,LHB,TNFSF11,PRL,AKT3,GCK,NRAS,STAT1,AKT2,STAT5A,CGA,SHC1,MAPK3,MAP2K1,SHC2,STAT5B,INS,PIK3CA,PIK3R1,ELF5,SOCS5
hsa04925	Aldosterone synthesis and secretion	0.000317754780273386	-8.05423060387448	82	81	0.0128571428571429	6300	7161	113,808,163688,5567,148327,4929,8911,810,1585,51305,5566,818,25865,109,115,1388,90993,1385,5330,3284,114,466,2778,747,775,8912,8913,57172,3164,51806,814,779,4881,196883,3710,5579,815,3709,64764,108,84876,805,185,2767,468,23683,3991,1583,776,5581,107,816,3708,5332,949,4158,3777,111,5587,5578,9586,3949,23236,5138,2776,801,6770,1589,5582,5331,8536,112,1386,10488,5568,91860,817,3283,57118,84699,221955	ADCY7,CALM3,CALML6,PRKACB,CREB3L4,NR4A2,CACNA1I,CALML3,CYP11B2,KCNK9,PRKACA,CAMK2G,PRKD2,ADCY3,ADCY9,ATF6B,CREB3L1,CREB1,PLCB2,HSD3B2,ADCY8,ATF1,GNAS,DAGLA,CACNA1C,CACNA1H,CACNA1G,CAMK1G,NR4A1,CALML5,CAMK4,CACNA1S,NPR1,ADCY4,ITPR3,PRKCB,CAMK2A,ITPR2,CREB3L2,ADCY2,ORAI1,CALM2,AGTR1,GNA11,ATF4,PRKD3,LIPE,CYP11A1,CACNA1D,PRKCE,ADCY1,CAMK2B,ITPR1,PLCB4,SCARB1,MC2R,KCNK3,ADCY5,PRKD1,PRKCA,CREB5,LDLR,PLCB1,PDE2A,GNAQ,CALM1,STAR,CYP21A2,PRKCG,PLCB3,CAMK1,ADCY6,ATF2,CREB3,PRKACG,CALML4,CAMK2D,HSD3B1,CAMK1D,CREB3L3,DAGLB
ko04925	Aldosterone synthesis and secretion	0.000317754780273386	-8.05423060387448	82	81	0.0128571428571429	6300	7161	5581,107,3991,1583,776,2767,468,23683,5578,9586,3949,4158,3777,111,5587,5332,949,816,3708,1589,5582,801,6770,23236,2776,5138,84699,57118,221955,91860,817,3283,10488,5568,8536,5331,112,1386,115,1388,90993,1385,5566,818,109,25865,810,1585,51305,5567,113,808,163688,4929,148327,8911,2778,747,466,5330,3284,114,814,779,3164,51806,8912,8913,57172,775,84876,805,185,3709,64764,108,5579,3710,815,4881,196883	PRKCE,ADCY1,LIPE,CYP11A1,CACNA1D,GNA11,ATF4,PRKD3,PRKCA,CREB5,LDLR,MC2R,KCNK3,ADCY5,PRKD1,PLCB4,SCARB1,CAMK2B,ITPR1,CYP21A2,PRKCG,CALM1,STAR,PLCB1,GNAQ,PDE2A,CREB3L3,CAMK1D,DAGLB,CALML4,CAMK2D,HSD3B1,CREB3,PRKACG,CAMK1,PLCB3,ADCY6,ATF2,ADCY9,ATF6B,CREB3L1,CREB1,PRKACA,CAMK2G,ADCY3,PRKD2,CALML3,CYP11B2,KCNK9,PRKACB,ADCY7,CALM3,CALML6,NR4A2,CREB3L4,CACNA1I,GNAS,DAGLA,ATF1,PLCB2,HSD3B2,ADCY8,CAMK4,CACNA1S,NR4A1,CALML5,CACNA1H,CACNA1G,CAMK1G,CACNA1C,ORAI1,CALM2,AGTR1,ITPR2,CREB3L2,ADCY2,PRKCB,ITPR3,CAMK2A,NPR1,ADCY4
hsa04390	Hippo signaling pathway	0.000367827935167578	-7.90789529661851	154	148	0.0234920634920635	6300	7161	1454,4087,5590,4092,25937,1742,7003,84962,7976,174,1856,654,7484,7159,7046,4089,5516,1495,51384,10413,374,6591,7471,51176,8323,8322,7534,60,8945,7476,83439,55233,5522,5500,23286,10297,7855,3996,1740,56288,60485,2932,7475,353500,5054,268,6934,10207,7481,329,5515,1496,286204,5499,23418,7474,7531,4771,71,81029,656,9113,1855,7161,595,10971,999,5520,4088,23291,27113,392255,84552,3398,6788,8313,8312,653,896,659,8994,92597,8321,4086,655,64398,7473,7472,8326,5521,11211,5584,1857,7529,7043,7042,1490,7479,6657,54361,8463,8200,5519,658,26524,650,332,126374,2736,7477,1739,2535,7480,6932,89780,151449,8324,3689,7532,7533,657,2246,7005,29119,1499,7478,324,23513,80326,5501,5518,7040,7048,166824,7004,1453,79981,8325,11186,652,4609,122786,3993,894,84612,85407,7483,7482	CSNK1E,SMAD2,PRKCZ,SMAD7,WWTR1,DLG4,TEAD1,AJUBA,FZD3,AFP,DVL2,BMP6,WNT9B,TP53BP2,TGFBR1,SMAD4,PPP2CB,CTNNA1,WNT16,YAP1,AREG,SNAI2,WNT1,LEF1,FZD6,FZD4,YWHAZ,ACTB,BTRC,WNT7A,TCF7L1,MOB1A,PPP2R2C,PPP1CB,WWC1,APC2,FZD5,LLGL1,DLG2,PARD3,SAV1,GSK3B,WNT6,BMP8A,SERPINE1,AMH,TCF7L2,PATJ,WNT11,BIRC2,PPP2CA,CTNNA2,CRB2,PPP1CA,CRB1,WNT5A,YWHAE,NF2,ACTG1,WNT5B,BMP8B,LATS1,DVL1,TP73,CCND1,YWHAQ,CDH1,PPP2R2A,SMAD3,FBXW11,BBC3,GDF6,PARD6G,ID2,STK3,AXIN2,AXIN1,BMP5,CCND3,BMPR2,LIMD1,MOB1B,FZD1,SMAD1,BMP7,PALS1,WNT3,WNT2,FZD9,PPP2R2B,FZD10,PRKCI,DVL3,YWHAB,TGFB3,TGFB2,CCN2,WNT8B,SOX2,WNT4,TEAD2,GDF5,PPP2R1B,BMPR1B,LATS2,BMP2,BIRC5,WTIP,GLI2,WNT7B,DLG1,FZD2,WNT10B,TCF7,WNT3A,GDF7,FZD7,ITGB2,YWHAG,YWHAH,BMPR1A,FGF1,TEAD3,CTNNA3,CTNNB1,WNT8A,APC,SCRIB,WNT10A,PPP1CC,PPP2R1A,TGFB1,TGFBR2,RASSF6,TEAD4,CSNK1D,FRMD1,FZD8,RASSF1,BMP4,MYC,FRMD6,LLGL2,CCND2,PARD6B,NKD1,WNT9A,WNT2B
ko04390	Hippo signaling pathway	0.000367827935167578	-7.90789529661851	154	148	0.0234920634920635	6300	7161	5518,5501,23513,80326,657,7532,7533,151449,3689,8324,324,7478,7005,29119,1499,2246,4609,652,11186,7483,7482,84612,85407,894,122786,3993,7004,166824,7048,7040,8325,1453,79981,5521,8326,7529,5584,11211,1857,653,896,659,8313,8312,3398,6788,7473,7472,92597,4086,8321,655,64398,8994,658,5519,8463,8200,89780,7480,6932,7477,1739,2535,650,26524,332,2736,126374,6657,7479,1490,7043,7042,54361,10207,5054,268,6934,5515,286204,1496,329,7481,56288,1740,3996,7855,353500,7475,60485,2932,23291,4088,5520,595,10971,999,7161,84552,392255,27113,7531,5499,23418,7474,1855,656,9113,81029,4771,71,7484,1856,654,7046,4089,7159,4092,5590,1742,25937,4087,1454,174,7976,84962,7003,55233,5522,83439,7476,8945,10297,23286,5500,51384,1495,5516,7534,60,51176,8323,8322,374,10413,6591,7471	PPP2R1A,PPP1CC,SCRIB,WNT10A,BMPR1A,YWHAG,YWHAH,GDF7,ITGB2,FZD7,APC,WNT8A,TEAD3,CTNNA3,CTNNB1,FGF1,MYC,BMP4,RASSF1,WNT9A,WNT2B,PARD6B,NKD1,CCND2,FRMD6,LLGL2,TEAD4,RASSF6,TGFBR2,TGFB1,FZD8,CSNK1D,FRMD1,PPP2R2B,FZD9,YWHAB,PRKCI,FZD10,DVL3,BMP5,CCND3,BMPR2,AXIN2,AXIN1,ID2,STK3,WNT3,WNT2,MOB1B,SMAD1,FZD1,BMP7,PALS1,LIMD1,BMPR1B,PPP2R1B,TEAD2,GDF5,WNT3A,WNT10B,TCF7,WNT7B,DLG1,FZD2,BMP2,LATS2,BIRC5,GLI2,WTIP,SOX2,WNT8B,CCN2,TGFB3,TGFB2,WNT4,PATJ,SERPINE1,AMH,TCF7L2,PPP2CA,CRB2,CTNNA2,BIRC2,WNT11,PARD3,DLG2,LLGL1,FZD5,BMP8A,WNT6,SAV1,GSK3B,FBXW11,SMAD3,PPP2R2A,CCND1,YWHAQ,CDH1,TP73,PARD6G,GDF6,BBC3,YWHAE,PPP1CA,CRB1,WNT5A,DVL1,BMP8B,LATS1,WNT5B,NF2,ACTG1,WNT9B,DVL2,BMP6,TGFBR1,SMAD4,TP53BP2,SMAD7,PRKCZ,DLG4,WWTR1,SMAD2,CSNK1E,AFP,FZD3,AJUBA,TEAD1,MOB1A,PPP2R2C,TCF7L1,WNT7A,BTRC,APC2,WWC1,PPP1CB,WNT16,CTNNA1,PPP2CB,YWHAZ,ACTB,LEF1,FZD6,FZD4,AREG,YAP1,SNAI2,WNT1
hsa04750	Inflammatory mediator regulation of TRP channels	0.000381710920508427	-7.87084698843523	97	95	0.0150793650793651	6300	7161	1573,815,3479,3709,805,8605,51806,624,123745,114,5335,4803,5321,808,5567,163688,5290,810,3269,51393,818,5029,5331,5568,817,1432,91860,2776,3357,6300,5336,4914,2150,3708,5601,111,59341,6714,3553,5501,5293,79054,5581,5734,5606,5600,5608,196883,3554,5579,3710,108,51802,283748,5732,5500,9311,255189,5588,5580,55515,5330,2778,113,623,8398,5295,100137049,109,5566,115,112,8503,5603,5602,5599,5499,5296,239,5291,3556,23236,8989,801,3356,5582,5583,162514,816,5332,5578,41,7442,107,40	CYP2J2,CAMK2A,IGF1,ITPR2,CALM2,PLA2G4C,CALML5,BDKRB2,PLA2G4E,ADCY8,PLCG1,NGF,PLA2G4A,CALM3,PRKACB,CALML6,PIK3CA,CALML3,HRH1,TRPV2,CAMK2G,P2RY2,PLCB3,PRKACG,CAMK2D,MAPK14,CALML4,GNAQ,HTR2B,MAPK12,PLCG2,NTRK1,F2RL1,ITPR1,MAPK9,ADCY5,TRPV4,SRC,IL1B,PPP1CC,PIK3CD,TRPM8,PRKCE,PTGER4,MAP2K3,MAPK11,MAP2K6,ADCY4,IL1R1,PRKCB,ITPR3,ADCY2,ASIC5,PLA2G4D,PTGER2,PPP1CB,ASIC3,PLA2G4F,PRKCQ,PRKCD,ASIC4,PLCB2,GNAS,ADCY7,BDKRB1,PLA2G6,PIK3R1,PLA2G4B,ADCY3,PRKACA,ADCY9,ADCY6,PIK3R3,MAPK13,MAPK10,MAPK8,PPP1CA,PIK3R2,ALOX12,PIK3CB,IL1RAP,PLCB1,TRPA1,CALM1,HTR2A,PRKCG,PRKCH,TRPV3,CAMK2B,PLCB4,PRKCA,ASIC1,TRPV1,ADCY1,ASIC2
ko04750	Inflammatory mediator regulation of TRP channels	0.000381710920508427	-7.87084698843523	97	95	0.0150793650793651	6300	7161	111,3553,59341,6714,3708,2150,5601,5581,79054,5606,5734,5293,5501,91860,1432,817,5331,5029,5568,5336,4914,6300,3357,2776,4803,624,5335,114,123745,3269,51393,818,808,163688,5567,5321,810,5290,3709,805,3479,815,1573,51806,8605,5578,816,162514,5332,40,107,7442,41,5296,5499,5602,5603,8503,112,5599,3356,801,5583,5582,23236,3556,5291,239,8989,2778,55515,5330,5566,109,100137049,115,113,5295,8398,623,51802,108,283748,3554,196883,5600,5608,3710,5579,5588,5580,255189,5500,5732,9311	ADCY5,IL1B,TRPV4,SRC,ITPR1,F2RL1,MAPK9,PRKCE,TRPM8,MAP2K3,PTGER4,PIK3CD,PPP1CC,CALML4,MAPK14,CAMK2D,PLCB3,P2RY2,PRKACG,PLCG2,NTRK1,MAPK12,HTR2B,GNAQ,NGF,BDKRB2,PLCG1,ADCY8,PLA2G4E,HRH1,TRPV2,CAMK2G,CALM3,CALML6,PRKACB,PLA2G4A,CALML3,PIK3CA,ITPR2,CALM2,IGF1,CAMK2A,CYP2J2,CALML5,PLA2G4C,PRKCA,CAMK2B,TRPV3,PLCB4,ASIC2,ADCY1,TRPV1,ASIC1,PIK3R2,PPP1CA,MAPK10,MAPK13,PIK3R3,ADCY6,MAPK8,HTR2A,CALM1,PRKCH,PRKCG,PLCB1,IL1RAP,PIK3CB,ALOX12,TRPA1,GNAS,ASIC4,PLCB2,PRKACA,ADCY3,PLA2G4B,ADCY9,ADCY7,PIK3R1,PLA2G6,BDKRB1,ASIC5,ADCY2,PLA2G4D,IL1R1,ADCY4,MAPK11,MAP2K6,ITPR3,PRKCB,PRKCQ,PRKCD,PLA2G4F,PPP1CB,PTGER2,ASIC3
hsa05205	Proteoglycans in cancer	0.000407105931397425	-7.80643713268326	203	193	0.0306349206349206	6300	7161	7484,1634,5329,3059,857,5295,4087,7097,7157,867,4193,288,29102,4313,6237,356,3685,23365,3710,8323,8322,3481,7410,6548,7481,6774,859,1975,6469,7855,54776,7023,816,22800,7475,6385,6654,5328,5499,2017,5603,81029,4233,1956,818,8326,3673,7074,3091,11211,5290,6194,5962,5604,8321,5335,7430,22808,81578,2335,208,5170,89780,10000,836,3709,7042,2065,7479,54361,3688,5594,5781,10818,815,3479,286,1026,1514,2817,3693,80326,5501,8324,9475,2885,6714,3593,1499,3708,355,7478,2475,4609,9138,7483,7482,5058,6608,5894,3339,2318,5568,5566,967,3791,7099,10855,3082,7057,7976,6198,51196,7476,7078,5500,60495,406991,51384,5600,7471,5579,60,6655,5829,6199,998,2247,23624,5578,2260,4660,5777,595,3549,5582,3265,5291,5727,868,287,5879,4318,406903,7474,5296,71,8503,960,858,27250,5567,5747,3690,2317,5595,2064,1839,7473,7472,6382,6383,3480,7477,2535,4893,7480,7422,7124,2099,3316,117581,5605,4060,3845,8826,2066,5293,4659,207,2549,387,79923,5336,673,6300,7291,7040,817,1432,84309,8325,3236	WNT9B,DCN,PLAUR,HCLS1,CAV1,PIK3R1,SMAD2,TLR2,TP53,CBL,MDM2,ANK3,DROSHA,MMP2,RRAS,FASLG,ITGAV,ARHGEF12,ITPR3,FZD6,FZD4,IGF2,VAV2,SLC9A1,WNT11,STAT3,CAV3,EIF4B,SHH,FZD5,PPP1R12C,TFAP4,CAMK2B,RRAS2,WNT6,SDC4,SOS1,PLAU,PPP1CA,CTTN,MAPK13,WNT5B,MET,EGFR,CAMK2G,FZD9,ITGA2,TIAM1,HIF1A,FZD10,PIK3CA,RPS6,RDX,MAP2K1,FZD1,PLCG1,EZR,MRAS,COL21A1,FN1,AKT2,PDPK1,WNT3A,AKT3,CASP3,ITPR2,TGFB2,ERBB3,WNT8B,WNT4,ITGB1,MAPK1,PTPN11,FRS2,CAMK2A,IGF1,ANK1,CDKN1A,CTSL,GPC1,ITGB5,WNT10A,PPP1CC,FZD7,ROCK2,GRB2,SRC,IL12B,CTNNB1,ITPR1,FAS,WNT8A,MTOR,MYC,ARHGEF1,WNT9A,WNT2B,PAK1,SMO,RAF1,HSPG2,FLNC,PRKACG,PRKACA,CD63,KDR,TLR4,HPSE,HGF,THBS1,FZD3,RPS6KB1,PLCE1,WNT7A,TIMP3,PPP1CB,HPSE2,MIR21,WNT16,MAPK11,WNT1,PRKCB,ACTB,SOS2,PXN,RPS6KB2,CDC42,FGF2,CBLC,PRKCA,FGFR1,PPP1R12B,PTPN6,CCND1,IHH,PRKCG,HRAS,PIK3CB,PTCH1,CBLB,ANK2,RAC1,MMP9,MIR10B,WNT5A,PIK3R2,ACTG1,PIK3R3,CD44,CAV2,PDCD4,PRKACB,PTK2,ITGB3,FLNB,MAPK3,ERBB2,HBEGF,WNT3,WNT2,SDC1,SDC2,IGF1R,WNT7B,FZD2,NRAS,WNT10B,VEGFA,TNF,ESR1,HSPB2,TWIST2,MAP2K2,LUM,KRAS,IQGAP1,ERBB4,PIK3CD,PPP1R12A,AKT1,GAB1,RHOA,NANOG,PLCG2,BRAF,MAPK12,TWIST1,TGFB1,CAMK2D,MAPK14,NUDT16L1,FZD8,HOXD10
ko05205	Proteoglycans in cancer	0.000407105931397425	-7.80643713268326	203	193	0.0306349206349206	6300	7161	8324,6714,2885,9475,3708,1499,3593,7478,355,286,1026,3693,2817,80326,1514,5501,6608,5894,2318,3339,5568,9138,4609,2475,7482,5058,7483,5604,8321,7430,5335,8326,818,3091,11211,7074,3673,6194,5962,5290,7042,3709,7479,2065,5594,3688,54361,815,3479,10818,5781,2335,22808,81578,208,5170,836,10000,89780,7855,6469,7023,54776,22800,816,7475,3481,7410,7481,6548,1975,859,6774,5499,2017,4233,5603,81029,1956,6385,5328,6654,7097,4087,7157,288,4193,867,1634,7484,5329,3059,5295,857,6237,4313,23365,3685,356,8322,8323,3710,29102,2549,4659,207,387,3845,8826,2066,5293,1432,817,7040,84309,3236,8325,5336,79923,6300,673,7291,5595,1839,2064,7472,7473,3690,5567,5747,2317,7124,3316,2099,5605,117581,4060,3480,6383,6382,2535,7477,7422,7480,4893,2247,998,5578,23624,2260,4660,5777,5829,6655,6199,7474,5296,5879,4318,406903,8503,71,27250,960,858,595,5582,3549,5291,3265,287,868,5727,7976,7057,3082,10855,3791,967,5566,7099,406991,60495,51384,7471,5600,60,5579,51196,7476,6198,7078,5500	FZD7,SRC,GRB2,ROCK2,ITPR1,CTNNB1,IL12B,WNT8A,FAS,ANK1,CDKN1A,ITGB5,GPC1,WNT10A,CTSL,PPP1CC,SMO,RAF1,FLNC,HSPG2,PRKACG,ARHGEF1,MYC,MTOR,WNT2B,PAK1,WNT9A,MAP2K1,FZD1,EZR,PLCG1,FZD9,CAMK2G,HIF1A,FZD10,TIAM1,ITGA2,RPS6,RDX,PIK3CA,TGFB2,ITPR2,WNT8B,ERBB3,MAPK1,ITGB1,WNT4,CAMK2A,IGF1,FRS2,PTPN11,FN1,MRAS,COL21A1,AKT2,PDPK1,CASP3,AKT3,WNT3A,FZD5,SHH,TFAP4,PPP1R12C,RRAS2,CAMK2B,WNT6,IGF2,VAV2,WNT11,SLC9A1,EIF4B,CAV3,STAT3,PPP1CA,CTTN,MET,MAPK13,WNT5B,EGFR,SDC4,PLAU,SOS1,TLR2,SMAD2,TP53,ANK3,MDM2,CBL,DCN,WNT9B,PLAUR,HCLS1,PIK3R1,CAV1,RRAS,MMP2,ARHGEF12,ITGAV,FASLG,FZD4,FZD6,ITPR3,DROSHA,GAB1,PPP1R12A,AKT1,RHOA,KRAS,IQGAP1,ERBB4,PIK3CD,MAPK14,CAMK2D,TGFB1,NUDT16L1,HOXD10,FZD8,PLCG2,NANOG,MAPK12,BRAF,TWIST1,MAPK3,HBEGF,ERBB2,WNT2,WNT3,ITGB3,PRKACB,PTK2,FLNB,TNF,HSPB2,ESR1,MAP2K2,TWIST2,LUM,IGF1R,SDC2,SDC1,FZD2,WNT7B,VEGFA,WNT10B,NRAS,FGF2,CDC42,PRKCA,CBLC,FGFR1,PPP1R12B,PTPN6,PXN,SOS2,RPS6KB2,WNT5A,PIK3R2,RAC1,MMP9,MIR10B,PIK3R3,ACTG1,PDCD4,CD44,CAV2,CCND1,PRKCG,IHH,PIK3CB,HRAS,ANK2,CBLB,PTCH1,FZD3,THBS1,HGF,HPSE,KDR,CD63,PRKACA,TLR4,MIR21,HPSE2,WNT16,WNT1,MAPK11,ACTB,PRKCB,PLCE1,WNT7A,RPS6KB1,TIMP3,PPP1CB
hsa04550	Signaling pathways regulating pluripotency of stem cells	0.000432560348144126	-7.74578870804499	139	134	0.0212698412698413	6300	7161	7476,10297,84759,51384,3718,8322,1749,3211,8323,8820,7471,5600,93,4211,3626,7484,1856,5295,4089,7994,4093,3976,4087,7976,4617,2263,64211,9314,4088,5978,6926,5291,3265,4762,5296,7474,10336,1855,3625,5603,81029,8503,6774,84333,7481,3717,4090,3624,7855,2247,7475,7044,2260,2932,3175,658,3480,208,89780,4893,10000,7480,648,2535,7477,3400,2103,6657,7479,5462,2261,3479,54361,5605,5594,9421,8326,5290,1857,11211,92,659,5604,100532731,5595,3720,8312,8313,7703,3398,7472,7473,3977,4086,8321,56916,3572,4609,652,79923,7482,7483,4838,6927,6300,5894,2264,6929,91,83729,130399,84108,5460,1432,8325,463,3399,90,3845,3716,5293,55183,80326,3670,2885,657,9869,207,5080,6498,8324,324,7478,1499	WNT7A,APC2,PCGF1,WNT16,JAK3,FZD4,DLX5,HOXB1,FZD6,HESX1,WNT1,MAPK11,ACVR2B,MEIS1,INHBC,WNT9B,DVL2,PIK3R1,SMAD4,KAT6A,SMAD9,LIF,SMAD2,FZD3,MYF5,FGFR2,LHX5,KLF4,SMAD3,REST,TBX3,PIK3CB,HRAS,NEUROG1,PIK3R2,WNT5A,PCGF3,DVL1,INHBB,MAPK13,WNT5B,PIK3R3,STAT3,PCGF5,WNT11,JAK2,SMAD5,INHBA,FZD5,FGF2,WNT6,LEFTY2,FGFR1,GSK3B,ONECUT1,BMPR1B,IGF1R,AKT2,WNT3A,NRAS,AKT3,WNT10B,BMI1,FZD2,WNT7B,ID4,ESRRB,SOX2,WNT8B,POU5F1B,FGFR3,IGF1,WNT4,MAP2K2,MAPK1,HAND1,FZD9,PIK3CA,DVL3,FZD10,ACVR2A,BMPR2,MAP2K1,COMMD3-BMI1,MAPK3,JARID2,AXIN1,AXIN2,PCGF2,ID2,WNT2,WNT3,LIFR,SMAD1,FZD1,SMARCAD1,IL6ST,MYC,BMP4,NANOG,WNT2B,WNT9A,NODAL,HNF1A,MAPK12,RAF1,FGFR4,TCF3,ACVR1B,INHBE,ACVR1C,PCGF6,POU5F1,MAPK14,FZD8,ZFHX3,ID3,ACVR1,KRAS,JAK1,PIK3CD,RIF1,WNT10A,ISL1,GRB2,BMPR1A,SETDB1,AKT1,PAX6,SKIL,FZD7,APC,WNT8A,CTNNB1
ko04550	Signaling pathways regulating pluripotency of stem cells	0.000432560348144126	-7.74578870804499	139	134	0.0212698412698413	6300	7161	652,4609,79923,4838,7482,7483,6927,6300,5894,2264,6929,84108,130399,1432,5460,91,83729,8325,3399,90,463,3716,3845,55183,5293,3670,80326,9869,207,2885,657,8324,6498,5080,7478,324,1499,208,3480,658,3175,10000,7480,89780,4893,2103,648,2535,7477,3400,7479,6657,5462,3479,2261,5594,5605,54361,8326,9421,5290,1857,11211,8312,8313,100532731,659,5595,5604,92,3720,7703,3398,3977,7472,7473,8321,4086,56916,3572,4088,5978,9314,6926,5291,3265,4762,10336,5296,7474,1855,8503,3625,81029,5603,6774,7481,3717,84333,4090,3624,7855,2247,7044,7475,2260,2932,7476,10297,84759,51384,1749,3211,8322,8323,3718,7471,5600,8820,93,4211,3626,1856,7484,4089,5295,7994,3976,4093,4087,7976,4617,2263,64211	BMP4,MYC,NANOG,NODAL,WNT2B,WNT9A,HNF1A,MAPK12,RAF1,FGFR4,TCF3,PCGF6,ACVR1C,MAPK14,POU5F1,ACVR1B,INHBE,FZD8,ID3,ACVR1,ZFHX3,JAK1,KRAS,RIF1,PIK3CD,ISL1,WNT10A,SETDB1,AKT1,GRB2,BMPR1A,FZD7,SKIL,PAX6,WNT8A,APC,CTNNB1,AKT2,IGF1R,BMPR1B,ONECUT1,AKT3,WNT10B,WNT3A,NRAS,ESRRB,BMI1,FZD2,WNT7B,ID4,WNT8B,SOX2,POU5F1B,IGF1,FGFR3,MAPK1,MAP2K2,WNT4,FZD9,HAND1,PIK3CA,DVL3,FZD10,AXIN1,AXIN2,COMMD3-BMI1,BMPR2,MAPK3,MAP2K1,ACVR2A,JARID2,PCGF2,ID2,LIFR,WNT2,WNT3,FZD1,SMAD1,SMARCAD1,IL6ST,SMAD3,REST,KLF4,TBX3,PIK3CB,HRAS,NEUROG1,PCGF3,PIK3R2,WNT5A,DVL1,PIK3R3,INHBB,WNT5B,MAPK13,STAT3,WNT11,JAK2,PCGF5,SMAD5,INHBA,FZD5,FGF2,LEFTY2,WNT6,FGFR1,GSK3B,WNT7A,APC2,PCGF1,WNT16,DLX5,HOXB1,FZD4,FZD6,JAK3,WNT1,MAPK11,HESX1,ACVR2B,MEIS1,INHBC,DVL2,WNT9B,SMAD4,PIK3R1,KAT6A,LIF,SMAD9,SMAD2,FZD3,MYF5,FGFR2,LHX5
ko04921	Oxytocin signaling pathway	0.000442702081117447	-7.72261351727168	152	146	0.0231746031746032	6300	7161	4208,115,109,10398,100137049,784,5566,3760,3768,113,3725,5530,5598,2778,2770,4775,5330,255189,814,5294,9254,952,146850,57172,2977,5500,283748,108,60,5579,3710,196883,4881,340156,107,781,3763,776,3762,5607,140465,10369,6261,5533,54776,5532,2773,59283,5578,5997,5564,53632,5332,27091,4660,816,5582,801,595,4776,23533,2353,3265,2983,23236,2982,5021,57118,5499,5565,786,1956,71,112,4846,7226,3759,818,85366,1938,810,3765,5321,808,5567,163688,59284,5595,5604,783,10368,5535,5020,114,123745,4882,785,3770,779,51806,4893,8605,775,91807,805,4638,59285,5571,3709,815,5563,5743,5562,5594,5605,5534,29904,1026,4637,55799,3845,5501,6714,4659,51422,9475,111,4773,4772,387,3708,93589,6263,6262,2776,27092,10645,3761,5894,1827,817,2771,91860,5568,5331,8536	MEF2C,ADCY9,ADCY3,MYL9,PLA2G4B,CACNB3,PRKACA,KCNJ3,KCNJ12,ADCY7,JUN,PPP3CA,MAPK7,GNAS,GNAI1,NFATC3,PLCB2,PLA2G4F,CAMK4,PIK3CG,CACNA2D2,CD38,PIK3R6,CAMK1G,GUCY1A2,PPP1CB,PLA2G4D,ADCY2,ACTB,PRKCB,ITPR3,ADCY4,NPR1,MYLK4,ADCY1,CACNA2D1,KCNJ6,CACNA1D,KCNJ5,MAP2K5,MYL6B,CACNG2,RYR1,PPP3CC,PPP1R12C,PPP3CB,GNAI3,CACNG8,PRKCA,RGS2,PRKAB1,PRKAG3,PLCB4,CACNG5,PPP1R12B,CAMK2B,PRKCG,CALM1,CCND1,NFATC4,PIK3R5,FOS,HRAS,GUCY1B1,PLCB1,GUCY1A1,OXTR,CAMK1D,PPP1CA,PRKAB2,CACNG1,EGFR,ACTG1,ADCY6,NOS3,TRPM2,KCNJ2,CAMK2G,MYLK2,EEF2,CALML3,KCNJ9,PLA2G4A,CALM3,PRKACB,CALML6,CACNG7,MAPK3,MAP2K1,CACNB2,CACNG3,PPP3R2,OXT,ADCY8,PLA2G4E,NPR2,CACNB4,KCNJ14,CACNA1S,CALML5,NRAS,PLA2G4C,CACNA1C,MYLK3,CALM2,MYLK,CACNG6,PRKAG1,ITPR2,CAMK2A,PRKAA2,PTGS2,PRKAA1,MAPK1,MAP2K2,PPP3R1,EEF2K,CDKN1A,MYL6,CACNA2D3,KRAS,PPP1CC,SRC,PPP1R12A,PRKAG2,ROCK2,ADCY5,NFATC2,NFATC1,RHOA,ITPR1,CACNA2D4,RYR3,RYR2,GNAQ,CACNG4,CAMKK2,KCNJ4,RAF1,RCAN1,CAMK2D,GNAI2,CALML4,PRKACG,PLCB3,CAMK1
hsa04921	Oxytocin signaling pathway	0.000442702081117447	-7.72261351727168	152	146	0.0231746031746032	6300	7161	140465,10369,6261,5607,781,3763,3762,776,340156,107,4660,816,27091,5332,53632,5997,5564,5578,59283,5533,54776,2773,5532,23236,2983,2982,3265,23533,2353,4776,595,801,5582,112,71,1956,5565,786,5499,57118,5021,113,3760,3768,5566,109,10398,100137049,784,115,4208,5330,4775,5530,3725,2770,5598,2778,5500,2977,57172,5294,9254,146850,952,255189,814,196883,4881,60,3710,5579,108,283748,5501,55799,3845,1026,4637,29904,3708,4773,387,4772,111,51422,9475,6714,4659,3761,27092,10645,2776,6263,6262,93589,8536,5331,5568,2771,91860,817,1827,5894,808,163688,5567,59284,5321,810,3765,1938,85366,3759,818,7226,4846,785,4882,114,123745,5020,5604,5595,10368,5535,783,775,8605,91807,4893,51806,779,3770,5605,5594,5534,5563,5743,5562,815,59285,3709,5571,4638,805	MYL6B,CACNG2,RYR1,MAP2K5,CACNA2D1,KCNJ6,KCNJ5,CACNA1D,MYLK4,ADCY1,PPP1R12B,CAMK2B,CACNG5,PLCB4,PRKAG3,RGS2,PRKAB1,PRKCA,CACNG8,PPP3CC,PPP1R12C,GNAI3,PPP3CB,PLCB1,GUCY1B1,GUCY1A1,HRAS,PIK3R5,FOS,NFATC4,CCND1,CALM1,PRKCG,ADCY6,ACTG1,EGFR,PRKAB2,CACNG1,PPP1CA,CAMK1D,OXTR,ADCY7,KCNJ3,KCNJ12,PRKACA,ADCY3,MYL9,PLA2G4B,CACNB3,ADCY9,MEF2C,PLCB2,NFATC3,PPP3CA,JUN,GNAI1,MAPK7,GNAS,PPP1CB,GUCY1A2,CAMK1G,PIK3CG,CACNA2D2,PIK3R6,CD38,PLA2G4F,CAMK4,ADCY4,NPR1,ACTB,ITPR3,PRKCB,ADCY2,PLA2G4D,PPP1CC,CACNA2D3,KRAS,CDKN1A,MYL6,EEF2K,ITPR1,NFATC2,RHOA,NFATC1,ADCY5,PRKAG2,ROCK2,SRC,PPP1R12A,KCNJ4,CACNG4,CAMKK2,GNAQ,RYR3,RYR2,CACNA2D4,CAMK1,PLCB3,PRKACG,GNAI2,CALML4,CAMK2D,RCAN1,RAF1,CALM3,CALML6,PRKACB,CACNG7,PLA2G4A,CALML3,KCNJ9,EEF2,MYLK2,KCNJ2,CAMK2G,TRPM2,NOS3,CACNB4,NPR2,ADCY8,PLA2G4E,OXT,MAP2K1,MAPK3,CACNG3,PPP3R2,CACNB2,CACNA1C,PLA2G4C,MYLK3,NRAS,CALML5,CACNA1S,KCNJ14,MAP2K2,MAPK1,PPP3R1,PRKAA2,PTGS2,PRKAA1,CAMK2A,CACNG6,ITPR2,PRKAG1,MYLK,CALM2
hsa04144	Endocytosis	0.000456037607367472	-7.69293527955345	260	245	0.0388888888888889	6300	7161	3560,4734,1601,51324,23550,4233,79720,1956,9559,55616,11021,11031,9135,10564,10254,9798,2352,84552,7456,3949,56288,5119,10565,6455,23111,8723,3310,859,91782,26286,2060,8411,10617,9897,137492,84249,2149,10552,30844,3305,4087,7037,30845,2263,80230,5156,273,4193,9267,5338,156,23327,867,409,11059,138429,8853,92421,5979,7046,131890,857,116985,2264,26119,10095,155,11311,57403,3559,26056,7251,2869,3798,79643,3482,4914,3135,84313,27128,377,6714,3105,5869,56904,10094,64750,7042,5868,7043,11267,2348,2065,51028,2261,8394,8724,253725,3577,147179,27131,9266,1175,23325,89853,29924,8976,30846,274,3799,27183,2868,22841,83737,1785,10015,390243,830,51534,25978,858,154,9727,8729,4088,5337,51652,3265,55737,8766,10109,26052,868,3306,998,22905,23624,93661,9744,55040,64145,1173,28964,381,8218,1436,9829,23396,254122,832,55738,23362,7189,161,9101,6456,3133,2870,60682,84364,10938,2350,408,3107,9372,23527,58533,5590,6011,9922,6642,57132,116988,6643,5878,1211,10093,3791,3304,3312,100287171,116986,9765,9815,7048,7040,153,8027,7879,10092,10193,64411,4218,64744,163,84440,9525,3800,51100,9265,382,57154,84612,387680,51510,644150,160,387,80223,116987,5867,3134,10890,2066,51019,112936,3579,58513,157,2321,116984,5371,93343,1213,81873,1212,375,55048,3480,1759,3106,6457,50807,5662,440073,7852,51699,116983,1950,128866,5584,1234,8395,9146,3815	IL2RB,NEDD4,DAB2,SPG21,PSD4,MET,VPS37B,EGFR,VPS26A,ASAP3,RAB35,RAB31,RABEP1,ARFGEF2,STAM2,IST1,FOLR3,PARD6G,WIPF1,LDLR,PARD3,CHMP1A,ARFGEF1,SH3GL1,SPART,SNX4,HSPA6,CAV3,CHMP7,ARFGAP3,EPS15,EEA1,STAMBP,WASHC5,VPS37A,PSD2,F2R,ARPC1A,EHD4,HSPA1L,SMAD2,TFRC,EHD3,FGFR2,RUFY1,PDGFRA,AMPH,MDM2,CYTH1,PLD2,GRK2,NEDD4L,CBL,ARRB2,WWP1,PIP5KL1,ASAP2,CHMP4C,RET,TGFBR1,GRK7,CAV1,ARAP1,FGFR4,LDLRAP1,ARPC1B,ADRB3,VPS45,RAB22A,IL2RA,RAB11FIP5,TSG101,GRK5,KIF5A,CHMP6,IGF2R,NTRK1,HLA-G,VPS25,CYTH4,ARF3,SRC,HLA-A,RAB5B,SH3GLB2,ARPC3,SMURF2,TGFB2,RAB5A,TGFB3,SNF8,FOLR1,ERBB3,VPS36,FGFR3,PIP5K1A,SNX3,WASHC2C,CXCR1,WIPF2,SNX5,CYTH2,AP2S1,WASHC4,MVB12B,EPN1,WASL,EHD2,BIN1,KIF5B,VPS4A,GRK4,RAB11FIP2,ITCH,DNM2,PDCD6IP,IZUMO1R,CAPZA2,VTA1,CHMP2B,CAV2,ADRB2,RAB11FIP3,GBF1,SMAD3,PLD1,CHMP3,HRAS,VPS35,RAB11A,ARPC2,DNM3,CBLB,HSPA2,CDC42,EPN2,CBLC,CAPZA3,ACAP1,EPN3,RBSN,AP2M1,GIT1,ARF5,CLTCL1,CSF1R,DNAJC6,PIP5K1C,SNX32,CAPZB,ARFGAP1,PSD3,TRAF6,AP2A2,USP8,SH3GL2,HLA-E,GRK6,SMAP1,ARFGAP2,EHD1,FOLR2,ARRB1,HLA-C,ZFYVE9,ACAP2,SNX6,PRKCZ,GRK1,IQSEC1,SNX1,CHMP1B,AGAP3,SNX2,RAB5C,CLTA,ARPC4,KDR,HSPA1B,HSPA8,WASHC1,AGAP2,ZFYVE16,GIT2,TGFBR2,TGFB1,ADRB1,STAM,RAB7A,ARPC5,RNF41,ARAP3,RAB8A,SMAP2,AP2B1,RAB11FIP4,VPS4B,KIF5C,SH3GLB1,CYTH3,ARF6,SMURF1,PARD6B,WASHC2A,CHMP5,WIPF3,AP2A1,RHOA,RAB11FIP1,AGAP1,RAB4A,HLA-F,RAB10,ERBB4,WASHC3,VPS26B,CXCR2,EPS15L1,GRK3,FLT1,ARAP2,PML,MVB12A,CLTC,ARPC5L,CLTB,ARF1,VPS37C,IGF1R,DNM1,HLA-B,SH3GL3,ASAP1,PSD,IQSEC3,CXCR4,VPS29,ACAP3,EGF,CHMP4B,PRKCI,CCR5,PIP5K1B,HGS,KIT
ko04144	Endocytosis	0.000456037607367472	-7.69293527955345	260	245	0.0388888888888889	6300	7161	153,8027,7879,10092,7040,7048,64411,10193,163,4218,64744,382,84612,57154,84440,9525,9265,3800,51100,387680,387,644150,51510,160,5867,80223,116987,51019,3134,10890,2066,157,2321,112936,3579,58513,1213,93343,81873,1212,116984,5371,55048,3480,1759,3106,375,50807,5662,6457,51699,440073,7852,116983,128866,1950,8395,9146,3815,5584,1234,10015,390243,83737,22841,1785,25978,858,830,51534,4088,9727,154,8729,8766,10109,868,26052,51652,5337,3265,55737,22905,23624,3306,998,9744,55040,93661,381,28964,8218,64145,1173,9829,1436,254122,832,55738,7189,23362,23396,161,9101,3133,2870,6456,408,2350,3107,60682,84364,10938,58533,6011,5590,9372,23527,10093,6642,9922,57132,116988,6643,5878,1211,3791,3304,9765,9815,3312,100287171,116986,2264,116985,57403,3559,26056,26119,155,10095,11311,2869,3798,79643,3482,3135,4914,7251,84313,27128,377,6714,5869,3105,56904,10094,64750,2348,2065,51028,7042,5868,7043,11267,2261,8724,253725,8394,147179,3577,9266,27131,23325,89853,29924,1175,3799,27183,2868,8976,274,30846,1601,51324,23550,3560,4734,1956,9559,4233,79720,9135,10564,10254,9798,55616,11021,11031,2352,84552,7456,3949,56288,10565,6455,5119,23111,859,91782,8723,3310,2060,8411,26286,10617,9897,137492,10552,30844,3305,84249,2149,30845,4087,7037,273,9267,4193,156,5338,867,23327,409,80230,2263,5156,138429,8853,11059,5979,7046,857,131890,92421	ADRB1,STAM,RAB7A,ARPC5,TGFB1,TGFBR2,ARAP3,RNF41,AP2B1,RAB8A,SMAP2,ARF6,PARD6B,SMURF1,RAB11FIP4,VPS4B,CYTH3,KIF5C,SH3GLB1,WASHC2A,RHOA,WIPF3,CHMP5,AP2A1,RAB4A,RAB11FIP1,AGAP1,WASHC3,HLA-F,RAB10,ERBB4,GRK3,FLT1,VPS26B,CXCR2,EPS15L1,CLTC,MVB12A,ARPC5L,CLTB,ARAP2,PML,VPS37C,IGF1R,DNM1,HLA-B,ARF1,ASAP1,PSD,SH3GL3,VPS29,IQSEC3,CXCR4,ACAP3,CHMP4B,EGF,PIP5K1B,HGS,KIT,PRKCI,CCR5,PDCD6IP,IZUMO1R,ITCH,RAB11FIP2,DNM2,CHMP2B,CAV2,CAPZA2,VTA1,SMAD3,RAB11FIP3,ADRB2,GBF1,RAB11A,ARPC2,CBLB,DNM3,CHMP3,PLD1,HRAS,VPS35,EPN2,CBLC,HSPA2,CDC42,ACAP1,EPN3,CAPZA3,ARF5,GIT1,CLTCL1,RBSN,AP2M1,DNAJC6,CSF1R,SNX32,CAPZB,ARFGAP1,TRAF6,PSD3,PIP5K1C,AP2A2,USP8,HLA-E,GRK6,SH3GL2,ARRB1,FOLR2,HLA-C,SMAP1,ARFGAP2,EHD1,SNX6,GRK1,PRKCZ,ZFYVE9,ACAP2,ARPC4,SNX1,IQSEC1,CHMP1B,AGAP3,SNX2,RAB5C,CLTA,KDR,HSPA1B,ZFYVE16,GIT2,HSPA8,WASHC1,AGAP2,FGFR4,ARAP1,RAB22A,IL2RA,RAB11FIP5,LDLRAP1,ADRB3,ARPC1B,VPS45,GRK5,KIF5A,CHMP6,IGF2R,HLA-G,NTRK1,TSG101,VPS25,CYTH4,ARF3,SRC,RAB5B,HLA-A,SH3GLB2,ARPC3,SMURF2,FOLR1,ERBB3,VPS36,TGFB2,RAB5A,TGFB3,SNF8,FGFR3,SNX3,WASHC2C,PIP5K1A,WIPF2,CXCR1,CYTH2,SNX5,WASHC4,MVB12B,EPN1,AP2S1,KIF5B,VPS4A,GRK4,WASL,BIN1,EHD2,DAB2,SPG21,PSD4,IL2RB,NEDD4,EGFR,VPS26A,MET,VPS37B,RABEP1,ARFGEF2,STAM2,IST1,ASAP3,RAB35,RAB31,FOLR3,PARD6G,WIPF1,LDLR,PARD3,ARFGEF1,SH3GL1,CHMP1A,SPART,CAV3,CHMP7,SNX4,HSPA6,EPS15,EEA1,ARFGAP3,STAMBP,WASHC5,VPS37A,ARPC1A,EHD4,HSPA1L,PSD2,F2R,EHD3,SMAD2,TFRC,AMPH,CYTH1,MDM2,GRK2,PLD2,CBL,NEDD4L,ARRB2,RUFY1,FGFR2,PDGFRA,PIP5KL1,ASAP2,WWP1,RET,TGFBR1,CAV1,GRK7,CHMP4C
ko04150	mTOR signaling pathway	0.00053227979821365	-7.53834127038693	150	144	0.0228571428571429	6300	7161	51606,57521,81029,8503,6009,1855,5296,7474,3551,153129,23175,5291,3265,6654,8140,51256,84219,83667,5582,2932,57600,7475,3643,7855,54468,10641,9470,5578,6199,7481,1975,245973,6655,81929,90423,7471,5579,8322,8323,127124,58528,8408,51384,6396,7132,526,7476,6198,2887,4041,92335,5728,8131,7976,9550,64121,3667,6794,10670,5295,7484,10542,51382,1856,9894,8325,55615,528,5894,55004,7249,8649,673,7482,7483,96459,64223,220441,2475,54541,201163,64798,79726,9681,387,6196,7478,8324,2885,207,80326,525,9675,5293,1978,3845,4040,529,523,54361,1977,5605,6446,5594,6249,5563,5562,55437,3479,7124,51719,7479,2535,7477,5170,89780,4893,84335,6520,10000,7480,6195,1147,6502,9706,208,3480,8321,7472,7473,28956,7248,389541,5595,5604,81617,1857,11211,3630,253260,6194,5290,8326,79109	ATP6V1H,RPTOR,WNT5B,PIK3R3,RHEB,DVL1,PIK3R2,WNT5A,IKBKB,SLC38A9,LPIN1,PIK3CB,HRAS,SOS1,SLC7A5,TBC1D7,WDR24,SESN2,PRKCG,GSK3B,FNIP2,WNT6,INSR,FZD5,MIOS,NPRL2,EIF4E2,PRKCA,RPS6KB2,WNT11,EIF4B,ATP6V1C2,SOS2,SEH1L,ATP6V1E2,WNT1,PRKCB,FZD4,FZD6,ATP6V1G3,RRAGD,ULK1,WNT16,SEC13,TNFRSF1A,ATP6V1B2,WNT7A,RPS6KB1,GRB10,LRP5,STRADA,PTEN,NPRL3,FZD3,ATP6V1G1,RRAGC,IRS1,STK11,RRAGA,PIK3R1,WNT9B,LAMTOR5,ATP6V1D,DVL2,TELO2,FZD8,PRR5,ATP6V1C1,RAF1,LAMTOR1,TSC2,LAMTOR3,BRAF,WNT2B,WNT9A,FNIP1,MLST8,RNF152,MTOR,DDIT4,FLCN,DEPTOR,WDR59,DEPDC5,RHOA,RPS6KA2,WNT8A,FZD7,GRB2,AKT1,WNT10A,ATP6V1B1,TTI1,PIK3CD,EIF4EBP1,KRAS,LRP6,ATP6V1E1,ATP6V1A,WNT4,EIF4E,MAP2K2,SGK1,MAPK1,CLIP1,PRKAA2,PRKAA1,STRADB,IGF1,TNF,CAB39,WNT8B,FZD2,WNT7B,PDPK1,WNT3A,NRAS,AKT1S1,SLC3A2,AKT3,WNT10B,RPS6KA1,CHUK,SKP2,ULK2,AKT2,IGF1R,FZD1,WNT2,WNT3,LAMTOR2,TSC1,LAMTOR4,MAPK3,MAP2K1,CAB39L,DVL3,FZD10,INS,RICTOR,RPS6,PIK3CA,FZD9,MAPKAP1
hsa04150	mTOR signaling pathway	0.00053227979821365	-7.53834127038693	150	144	0.0228571428571429	6300	7161	81929,6655,245973,1975,7481,6199,9470,5578,10641,7855,54468,3643,7475,57600,2932,5582,83667,84219,51256,8140,6654,3265,5291,23175,153129,3551,7474,5296,1855,6009,8503,81029,51606,57521,1856,10542,51382,7484,5295,10670,6794,3667,64121,9550,7976,8131,5728,92335,4041,2887,6198,7476,526,7132,6396,51384,8408,58528,127124,8323,8322,5579,7471,90423,523,529,4040,3845,1978,5293,9675,525,80326,207,2885,8324,7478,6196,387,9681,79726,64798,201163,2475,54541,220441,96459,64223,7483,7482,673,8649,55004,7249,5894,528,55615,8325,9894,79109,8326,5290,6194,253260,3630,11211,1857,81617,5595,5604,389541,7248,7473,28956,7472,8321,3480,208,9706,1147,6502,6195,7480,10000,84335,6520,4893,89780,5170,7477,2535,7479,51719,7124,55437,3479,5562,5563,6249,6446,5605,5594,1977,54361	SEH1L,SOS2,ATP6V1C2,EIF4B,WNT11,RPS6KB2,EIF4E2,PRKCA,NPRL2,FZD5,MIOS,INSR,WNT6,FNIP2,GSK3B,PRKCG,SESN2,WDR24,TBC1D7,SLC7A5,SOS1,HRAS,PIK3CB,LPIN1,SLC38A9,IKBKB,WNT5A,PIK3R2,DVL1,RHEB,PIK3R3,WNT5B,ATP6V1H,RPTOR,DVL2,LAMTOR5,ATP6V1D,WNT9B,PIK3R1,RRAGA,STK11,IRS1,RRAGC,ATP6V1G1,FZD3,NPRL3,PTEN,STRADA,LRP5,GRB10,RPS6KB1,WNT7A,ATP6V1B2,TNFRSF1A,SEC13,WNT16,ULK1,RRAGD,ATP6V1G3,FZD6,FZD4,PRKCB,WNT1,ATP6V1E2,ATP6V1A,ATP6V1E1,LRP6,KRAS,EIF4EBP1,PIK3CD,TTI1,ATP6V1B1,WNT10A,AKT1,GRB2,FZD7,WNT8A,RPS6KA2,RHOA,DEPDC5,WDR59,DEPTOR,FLCN,MTOR,DDIT4,RNF152,FNIP1,MLST8,WNT9A,WNT2B,BRAF,LAMTOR3,LAMTOR1,TSC2,RAF1,ATP6V1C1,PRR5,FZD8,TELO2,MAPKAP1,FZD9,PIK3CA,RPS6,RICTOR,INS,FZD10,DVL3,CAB39L,MAPK3,MAP2K1,LAMTOR4,TSC1,WNT3,LAMTOR2,WNT2,FZD1,IGF1R,AKT2,ULK2,CHUK,SKP2,RPS6KA1,WNT10B,AKT3,AKT1S1,SLC3A2,NRAS,WNT3A,PDPK1,WNT7B,FZD2,WNT8B,CAB39,TNF,STRADB,IGF1,PRKAA1,PRKAA2,CLIP1,SGK1,MAP2K2,MAPK1,EIF4E,WNT4
hsa04668	TNF signaling pathway	0.000591380596018654	-7.43305076133331	108	105	0.0166666666666667	6300	7161	1435,6347,64127,5600,5608,1326,6374,23118,8837,6885,7187,7132,7133,602,3976,3725,9530,3569,7128,8809,7412,1385,10059,148327,6401,5295,8737,83737,3551,4318,5296,84699,1386,8503,9021,8772,5603,5602,840,5599,5970,5291,3726,6376,2920,2353,5609,192111,7188,7424,843,329,1906,64764,7124,3600,5594,5743,1147,1051,208,4049,2919,836,10000,197259,6364,4217,5604,5595,841,4323,6352,9020,4792,10454,1388,90993,5290,3627,2921,1432,6416,8986,10488,3383,330,6300,8717,207,9586,3553,11035,4790,5601,153090,4314,7185,355,1437,5606,182,468,9252,5293	CSF1,CCL2,NOD2,MAPK11,MAP2K6,MAP3K8,CXCL5,TAB2,CFLAR,MAP3K7,TRAF3,TNFRSF1A,TNFRSF1B,BCL3,LIF,JUN,BAG4,IL6,TNFAIP3,IL18R1,VCAM1,CREB1,DNM1L,CREB3L4,SELE,PIK3R1,RIPK1,ITCH,IKBKB,MMP9,PIK3R2,CREB3L3,ATF2,PIK3R3,SOCS3,FADD,MAPK13,MAPK10,CASP7,MAPK8,RELA,PIK3CB,JUNB,CX3CL1,CXCL2,FOS,MAP2K7,PGAM5,TRAF5,VEGFC,CASP10,BIRC2,EDN1,CREB3L2,TNF,IL15,MAPK1,PTGS2,CHUK,CEBPB,AKT2,LTA,CXCL1,CASP3,AKT3,MLKL,CCL20,MAP3K5,MAP2K1,MAPK3,CASP8,MMP14,CCL5,MAP3K14,NFKBIA,TAB1,ATF6B,CREB3L1,PIK3CA,CXCL10,CXCL3,MAPK14,MAP2K4,RPS6KA4,CREB3,ICAM1,BIRC3,MAPK12,TRADD,AKT1,CREB5,IL1B,RIPK3,NFKB1,MAPK9,DAB2IP,MMP3,TRAF1,FAS,CSF2,MAP2K3,JAG1,ATF4,RPS6KA5,PIK3CD
ko04668	TNF signaling pathway	0.000591380596018654	-7.43305076133331	108	105	0.0166666666666667	6300	7161	8986,10488,1432,6416,6300,3383,330,11035,7185,355,4790,153090,4314,5601,3553,207,8717,9586,182,468,5293,9252,5606,1437,5594,5743,64764,7124,3600,4049,2919,836,10000,197259,1051,1147,208,6352,841,4323,4792,9020,6364,4217,5604,5595,2921,5290,3627,10454,1388,90993,8772,5603,5602,8503,1386,9021,5599,840,4318,5296,83737,3551,84699,2920,6376,3726,5291,2353,5970,192111,7188,5609,329,1906,843,7424,1326,6374,5600,5608,23118,8837,1435,64127,6347,7187,7132,7133,6885,3569,9530,8809,7128,602,3725,3976,6401,148327,10059,8737,5295,1385,7412	RPS6KA4,CREB3,MAPK14,MAP2K4,MAPK12,ICAM1,BIRC3,RIPK3,TRAF1,FAS,NFKB1,DAB2IP,MMP3,MAPK9,IL1B,AKT1,TRADD,CREB5,JAG1,ATF4,PIK3CD,RPS6KA5,MAP2K3,CSF2,MAPK1,PTGS2,CREB3L2,TNF,IL15,LTA,CXCL1,CASP3,AKT3,MLKL,CEBPB,CHUK,AKT2,CCL5,CASP8,MMP14,NFKBIA,MAP3K14,CCL20,MAP3K5,MAP2K1,MAPK3,CXCL3,PIK3CA,CXCL10,TAB1,ATF6B,CREB3L1,FADD,MAPK13,MAPK10,PIK3R3,ATF2,SOCS3,MAPK8,CASP7,MMP9,PIK3R2,ITCH,IKBKB,CREB3L3,CXCL2,CX3CL1,JUNB,PIK3CB,FOS,RELA,PGAM5,TRAF5,MAP2K7,BIRC2,EDN1,CASP10,VEGFC,MAP3K8,CXCL5,MAPK11,MAP2K6,TAB2,CFLAR,CSF1,NOD2,CCL2,TRAF3,TNFRSF1A,TNFRSF1B,MAP3K7,IL6,BAG4,IL18R1,TNFAIP3,BCL3,JUN,LIF,SELE,CREB3L4,DNM1L,RIPK1,PIK3R1,CREB1,VCAM1
ko04971	Gastric acid secretion	0.00072472567899685	-7.22971734850847	75	74	0.0117460317460317	6300	7161	54207,2778,2770,389015,480,5330,114,7430,85366,5566,109,3759,818,115,163688,5567,808,113,810,496,3709,4638,108,805,196883,60,3710,5579,815,51806,478,483,1131,91807,6750,111,5578,477,482,495,2773,3708,3776,816,2520,5332,887,340156,107,6548,2771,91860,817,3766,760,1080,3784,5331,112,5568,481,476,801,3773,3772,5582,9992,23236,2776,3758,6752,6522,115111,3274	KCNK10,GNAS,GNAI1,SLC9A4,ATP1A4,PLCB2,ADCY8,EZR,MYLK2,PRKACA,ADCY3,KCNJ2,CAMK2G,ADCY9,CALML6,PRKACB,CALM3,ADCY7,CALML3,ATP4B,ITPR2,MYLK,ADCY2,CALM2,ADCY4,ACTB,ITPR3,PRKCB,CAMK2A,CALML5,ATP1A3,ATP1B3,CHRM3,MYLK3,SST,ADCY5,PRKCA,ATP1A2,ATP1B2,ATP4A,GNAI3,ITPR1,KCNK2,CAMK2B,GAST,PLCB4,CCKBR,MYLK4,ADCY1,SLC9A1,GNAI2,CALML4,CAMK2D,KCNJ10,CA2,CFTR,KCNQ1,PLCB3,ADCY6,PRKACG,ATP1B1,ATP1A1,CALM1,KCNJ16,KCNJ15,PRKCG,KCNE2,PLCB1,GNAQ,KCNJ1,SSTR2,SLC4A2,SLC26A7,HRH2
hsa04971	Gastric acid secretion	0.00072472567899685	-7.22971734850847	75	74	0.0117460317460317	6300	7161	810,5567,113,163688,808,115,5566,85366,109,3759,818,5330,114,7430,389015,480,54207,2778,2770,6750,91807,483,478,1131,51806,60,5579,3710,815,196883,805,496,3709,4638,108,6548,887,107,340156,5332,3708,3776,816,2520,5578,477,482,2773,495,111,6752,115111,6522,3274,23236,9992,2776,3758,3773,3772,5582,801,5568,481,476,1080,3784,5331,112,760,2771,91860,3766,817	CALML3,PRKACB,ADCY7,CALML6,CALM3,ADCY9,PRKACA,MYLK2,ADCY3,KCNJ2,CAMK2G,PLCB2,ADCY8,EZR,SLC9A4,ATP1A4,KCNK10,GNAS,GNAI1,SST,MYLK3,ATP1B3,ATP1A3,CHRM3,CALML5,ACTB,PRKCB,ITPR3,CAMK2A,ADCY4,CALM2,ATP4B,ITPR2,MYLK,ADCY2,SLC9A1,CCKBR,ADCY1,MYLK4,PLCB4,ITPR1,KCNK2,CAMK2B,GAST,PRKCA,ATP1A2,ATP1B2,GNAI3,ATP4A,ADCY5,SSTR2,SLC26A7,SLC4A2,HRH2,PLCB1,KCNE2,GNAQ,KCNJ1,KCNJ16,KCNJ15,PRKCG,CALM1,PRKACG,ATP1B1,ATP1A1,CFTR,KCNQ1,PLCB3,ADCY6,CA2,GNAI2,CALML4,KCNJ10,CAMK2D
hsa05217	Basal cell carcinoma	0.000846842590120532	-7.0739957245969	55	55	0.00873015873015873	6300	7161	8313,7157,8312,7473,7472,7976,8321,7484,1856,27148,8326,11211,1857,51384,7479,51176,8323,8322,54361,7471,83439,7476,2737,10297,89780,7480,6932,7477,2535,650,2736,2735,6469,7855,8324,51684,324,7478,7475,2932,1499,64399,8643,6934,80326,7481,6608,7474,1855,8325,81029,652,7483,5727,7482	AXIN2,TP53,AXIN1,WNT3,WNT2,FZD3,FZD1,WNT9B,DVL2,STK36,FZD9,FZD10,DVL3,WNT16,WNT8B,LEF1,FZD6,FZD4,WNT4,WNT1,TCF7L1,WNT7A,GLI3,APC2,WNT3A,WNT10B,TCF7,WNT7B,FZD2,BMP2,GLI2,GLI1,SHH,FZD5,FZD7,SUFU,APC,WNT8A,WNT6,GSK3B,CTNNB1,HHIP,PTCH2,TCF7L2,WNT10A,WNT11,SMO,WNT5A,DVL1,FZD8,WNT5B,BMP4,WNT9A,PTCH1,WNT2B
ko05217	Basal cell carcinoma	0.000846842590120532	-7.0739957245969	55	55	0.00873015873015873	6300	7161	7475,7478,324,51684,1499,2932,2735,7855,8324,6469,7481,80326,64399,6934,8643,8325,1855,81029,7474,6608,7482,5727,7483,652,7976,7472,7473,8321,8312,8313,7157,1857,11211,8326,1856,27148,7484,8322,8323,51176,7471,54361,7479,51384,6932,7480,89780,10297,2736,650,2535,7477,83439,2737,7476	WNT6,WNT8A,APC,SUFU,CTNNB1,GSK3B,GLI1,FZD5,FZD7,SHH,WNT11,WNT10A,HHIP,TCF7L2,PTCH2,FZD8,DVL1,WNT5B,WNT5A,SMO,WNT2B,PTCH1,WNT9A,BMP4,FZD3,WNT2,WNT3,FZD1,AXIN1,AXIN2,TP53,DVL3,FZD10,FZD9,DVL2,STK36,WNT9B,FZD4,FZD6,LEF1,WNT1,WNT4,WNT8B,WNT16,TCF7,WNT10B,WNT3A,APC2,GLI2,BMP2,FZD2,WNT7B,TCF7L1,GLI3,WNT7A
hsa05224	Breast cancer	0.000919377297909806	-6.99181396718567	144	138	0.0219047619047619	6300	7161	3714,5604,5595,54567,6464,8312,8313,8321,2064,672,7472,7473,8648,8326,1950,1857,11211,3815,5290,1870,2099,7479,54361,5594,5605,3479,2250,53358,4853,10683,23462,208,3480,2535,7477,89780,4893,6932,7480,10000,8324,2885,5925,2259,207,1499,2246,324,1021,23493,7478,3845,4040,1026,80326,2257,182,5293,399694,5894,1019,8325,2253,2324,5241,2252,1452,8202,4609,675,2475,8817,2100,673,7482,7483,2254,122011,27006,3725,25759,26281,7157,26508,5728,8074,7976,7484,1856,5295,3280,10023,51384,7471,4791,8322,8323,51176,2255,7476,6198,4041,2248,83439,8600,10297,7855,6667,2247,1871,388585,2932,2260,2251,7475,2256,9965,6934,6655,6199,7481,4854,2249,5296,7474,1869,81029,8822,8503,26291,1956,1855,595,4855,5291,3265,6654,2353	JAG2,MAP2K1,MAPK3,DLL4,SHC1,AXIN1,AXIN2,FZD1,ERBB2,BRCA1,WNT2,WNT3,NCOA1,FZD9,EGF,DVL3,FZD10,KIT,PIK3CA,E2F2,ESR1,WNT8B,WNT4,MAPK1,MAP2K2,IGF1,FGF5,SHC3,NOTCH2,DLL3,HEY1,AKT2,IGF1R,FZD2,WNT7B,WNT3A,NRAS,TCF7,WNT10B,AKT3,FZD7,GRB2,RB1,FGF14,AKT1,CTNNB1,FGF1,APC,CDK6,HEY2,WNT8A,KRAS,LRP6,CDKN1A,WNT10A,FGF12,JAG1,PIK3CD,SHC4,RAF1,CDK4,FZD8,FGF8,FLT4,PGR,FGF7,CSNK1A1,NCOA3,MYC,BRCA2,MTOR,FGF18,ESR2,BRAF,WNT2B,WNT9A,FGF9,CSNK1A1L,FGF22,JUN,SHC2,FGF20,TP53,HEYL,PTEN,FGF23,FZD3,WNT9B,DVL2,PIK3R1,HES1,FRAT1,WNT16,WNT1,NFKB2,FZD4,FZD6,LEF1,FGF10,WNT7A,RPS6KB1,LRP5,FGF3,TCF7L1,TNFSF11,APC2,FZD5,SP1,FGF2,E2F3,HES5,GSK3B,FGFR1,FGF6,WNT6,FGF11,FGF19,TCF7L2,SOS2,RPS6KB2,WNT11,NOTCH3,FGF4,PIK3R2,WNT5A,E2F1,WNT5B,FGF17,PIK3R3,FGF21,EGFR,DVL1,CCND1,NOTCH4,PIK3CB,HRAS,SOS1,FOS
ko05224	Breast cancer	0.000919377297909806	-6.99181396718567	144	138	0.0219047619047619	6300	7161	1019,1452,8325,2253,2252,2324,5241,399694,5894,2100,673,7482,7483,8202,8817,675,4609,2475,2246,1499,1021,23493,7478,324,8324,207,2259,2885,5925,80326,2257,182,5293,3845,4040,1026,5594,5605,54361,2250,3479,53358,1870,7479,2099,2535,7477,6932,10000,7480,89780,4893,10683,23462,4853,3480,208,672,8321,2064,7472,7473,3714,6464,8312,8313,5595,5604,54567,1857,11211,5290,3815,8326,1950,8648,8503,8822,81029,1956,26291,1855,1869,7474,5296,5291,3265,2353,6654,4855,595,2251,2260,2932,7475,7855,2247,6667,388585,1871,7481,6199,4854,2249,6934,6655,9965,2256,7471,4791,8322,51176,2255,8323,3280,51384,10023,8600,10297,7476,6198,83439,4041,2248,5728,7976,8074,27006,122011,2254,7157,26508,25759,3725,26281,5295,1856,7484	CDK4,CSNK1A1,FZD8,FGF8,FGF7,FLT4,PGR,SHC4,RAF1,ESR2,BRAF,WNT2B,WNT9A,NCOA3,FGF18,BRCA2,MYC,MTOR,FGF1,CTNNB1,CDK6,HEY2,WNT8A,APC,FZD7,AKT1,FGF14,GRB2,RB1,WNT10A,FGF12,JAG1,PIK3CD,KRAS,LRP6,CDKN1A,MAPK1,MAP2K2,WNT4,FGF5,IGF1,SHC3,E2F2,WNT8B,ESR1,FZD2,WNT7B,TCF7,AKT3,WNT10B,WNT3A,NRAS,DLL3,HEY1,NOTCH2,IGF1R,AKT2,BRCA1,FZD1,ERBB2,WNT2,WNT3,JAG2,SHC1,AXIN1,AXIN2,MAPK3,MAP2K1,DLL4,DVL3,FZD10,PIK3CA,KIT,FZD9,EGF,NCOA1,PIK3R3,FGF17,WNT5B,EGFR,FGF21,DVL1,E2F1,WNT5A,PIK3R2,PIK3CB,HRAS,FOS,SOS1,NOTCH4,CCND1,FGF6,FGFR1,GSK3B,WNT6,FZD5,FGF2,SP1,HES5,E2F3,WNT11,RPS6KB2,NOTCH3,FGF4,TCF7L2,SOS2,FGF19,FGF11,WNT1,NFKB2,FZD4,LEF1,FGF10,FZD6,HES1,WNT16,FRAT1,TNFSF11,APC2,WNT7A,RPS6KB1,TCF7L1,LRP5,FGF3,PTEN,FZD3,FGF23,FGF22,CSNK1A1L,FGF9,TP53,HEYL,SHC2,JUN,FGF20,PIK3R1,DVL2,WNT9B
hsa05418	Fluid shear stress and atherosclerosis	0.00110069180068718	-6.81181638714303	142	136	0.0215873015873016	6300	7161	5599,9446,858,8503,71,5602,25828,5603,3551,2946,2939,5296,4318,5879,2353,5291,5880,2941,5155,5970,6385,3674,801,4259,6613,6612,2952,2953,5609,10365,1906,859,5607,5154,4257,60,1535,3685,5608,5600,3554,6347,1003,4258,9181,4313,387082,7132,5175,1843,2944,6885,3326,2938,5327,7157,2950,3725,5590,5598,5295,857,8878,6401,4208,93,7412,3791,653361,2947,90,9817,6416,1432,91860,4780,221357,6300,7341,445,652,119391,2949,3383,3320,4880,5601,4790,387,1499,59341,6714,207,3552,657,3553,7850,50508,3163,3162,5293,2817,1514,51588,5563,5562,805,1728,7124,7422,10000,208,6383,6382,658,51806,1147,3458,659,92,4217,7056,5290,2948,2940,810,5881,3690,808,7295,5747,163688,596,4846,4205,4688	MAPK8,GSTO1,CAV2,PIK3R3,ACTG1,MAPK10,TXN2,MAPK13,IKBKB,GSTM2,GSTA2,PIK3R2,MMP9,RAC1,FOS,PIK3CB,RAC2,GSTA4,PDGFB,RELA,SDC4,ITGA2B,CALM1,MGST3,SUMO2,SUMO3,GSTT1,GSTT2,MAP2K7,KLF2,EDN1,CAV3,MAP2K5,PDGFA,MGST1,ACTB,CYBA,ITGAV,MAP2K6,MAPK11,IL1R1,CCL2,CDH5,MGST2,ARHGEF2,MMP2,SUMO4,TNFRSF1A,PECAM1,DUSP1,GSTM1,MAP3K7,HSP90AB1,GSTA1,PLAT,TP53,GSTP1,JUN,PRKCZ,MAPK7,PIK3R1,CAV1,SQSTM1,SELE,MEF2C,ACVR2B,VCAM1,KDR,NCF1,GSTM3,ACVR1,KEAP1,MAP2K4,MAPK14,CALML4,NFE2L2,GSTA5,MAPK12,SUMO1,ASS1,BMP4,GSTO2,GSTM5,ICAM1,HSP90AA1,NPPC,MAPK9,NFKB1,RHOA,CTNNB1,TRPV4,SRC,AKT1,IL1A,BMPR1A,IL1B,IL1R2,NOX3,HMOX2,HMOX1,PIK3CD,GPC1,CTSL,PIAS4,PRKAA2,PRKAA1,CALM2,NQO1,TNF,VEGFA,AKT3,AKT2,SDC2,SDC1,BMPR1B,CALML5,CHUK,IFNG,BMPR2,ACVR2A,MAP3K5,THBD,PIK3CA,GSTM4,GSTA3,CALML3,RAC3,ITGB3,CALM3,TXN,PTK2,CALML6,BCL2,NOS3,MEF2A,NCF2
ko05418	Fluid shear stress and atherosclerosis	0.00110069180068718	-6.81181638714303	142	136	0.0215873015873016	6300	7161	4846,4205,596,4688,5290,5881,810,2948,2940,3690,5747,7295,163688,808,4217,7056,659,92,3458,208,658,6382,6383,1147,51806,10000,7422,805,1728,7124,5562,5563,51588,50508,5293,3162,3163,1514,2817,207,59341,6714,3553,657,3552,7850,4790,5601,4880,387,1499,119391,652,2949,3320,3383,4780,221357,7341,445,6300,6416,1432,91860,653361,90,2947,9817,7412,93,4208,3791,5295,857,8878,6401,2950,7157,5598,5590,3725,3326,2938,5327,1843,6885,2944,7132,5175,6347,4258,1003,387082,4313,9181,1535,60,5608,5600,3685,3554,4257,1906,5607,859,5154,6612,6613,2953,2952,10365,5609,4259,6385,5970,5155,3674,801,2353,5291,2941,5880,2946,2939,3551,5879,4318,5296,9446,858,5599,71,8503,5603,25828,5602	NOS3,MEF2A,BCL2,NCF2,PIK3CA,RAC3,CALML3,GSTM4,GSTA3,ITGB3,PTK2,TXN,CALML6,CALM3,MAP3K5,THBD,BMPR2,ACVR2A,IFNG,AKT2,BMPR1B,SDC1,SDC2,CHUK,CALML5,AKT3,VEGFA,CALM2,NQO1,TNF,PRKAA1,PRKAA2,PIAS4,NOX3,PIK3CD,HMOX1,HMOX2,CTSL,GPC1,AKT1,TRPV4,SRC,IL1B,BMPR1A,IL1A,IL1R2,NFKB1,MAPK9,NPPC,RHOA,CTNNB1,GSTO2,BMP4,GSTM5,HSP90AA1,ICAM1,NFE2L2,GSTA5,SUMO1,ASS1,MAPK12,MAP2K4,MAPK14,CALML4,NCF1,ACVR1,GSTM3,KEAP1,VCAM1,ACVR2B,MEF2C,KDR,PIK3R1,CAV1,SQSTM1,SELE,GSTP1,TP53,MAPK7,PRKCZ,JUN,HSP90AB1,GSTA1,PLAT,DUSP1,MAP3K7,GSTM1,TNFRSF1A,PECAM1,CCL2,MGST2,CDH5,SUMO4,MMP2,ARHGEF2,CYBA,ACTB,MAP2K6,MAPK11,ITGAV,IL1R1,MGST1,EDN1,MAP2K5,CAV3,PDGFA,SUMO3,SUMO2,GSTT2,GSTT1,KLF2,MAP2K7,MGST3,SDC4,RELA,PDGFB,ITGA2B,CALM1,FOS,PIK3CB,GSTA4,RAC2,GSTM2,GSTA2,IKBKB,RAC1,MMP9,PIK3R2,GSTO1,CAV2,MAPK8,ACTG1,PIK3R3,MAPK13,TXN2,MAPK10
hsa04022	cGMP-PKG signaling pathway	0.00151571631473768	-6.49186713675423	163	155	0.0246031746031746	6300	7161	7419,151,2977,5500,1258,146850,5294,4985,10672,6547,3710,4881,196883,108,7417,148327,6543,157855,113,4208,115,1385,10398,109,491,4775,27345,5330,3667,2770,5530,146,5350,4209,23533,2982,23236,134,2983,801,4776,154,476,10242,481,5140,112,1386,10105,84699,5499,4207,776,486,83447,1259,107,340156,4625,3643,5332,5532,2773,5593,5533,5592,1910,5997,10000,91807,775,208,3778,483,478,779,489,3764,51806,7408,2768,7416,5534,147,5605,100271849,5594,185,6546,8654,805,2626,4638,3709,64764,810,3630,291,163688,808,4846,4205,1388,152,90993,5139,85366,114,4882,480,9569,2969,624,5535,488,5595,5604,6722,10335,5138,2776,487,490,8660,10488,155,7225,5331,5894,153,91860,2771,3779,5501,148,2767,150,468,4879,140,5581,27094,387,4772,4773,493,1909,3708,207,4659,482,9586,477,9475,111	VDAC3,ADRA2B,GUCY1A2,PPP1CB,CNGB1,PIK3R6,PIK3CG,OPRD1,GNA13,SLC8A3,ITPR3,NPR1,ADCY4,ADCY2,VDAC2,CREB3L4,SLC8A2,KCNU1,ADCY7,MEF2C,ADCY9,CREB1,MYL9,ADCY3,ATP2B2,NFATC3,KCNMB4,PLCB2,IRS1,GNAI1,PPP3CA,ADRA1D,PLN,MEF2D,PIK3R5,GUCY1A1,PLCB1,ADORA1,GUCY1B1,CALM1,NFATC4,ADRB2,ATP1A1,KCNMB2,ATP1B1,PDE3B,ADCY6,ATF2,PPIF,CREB3L3,PPP1CA,BORCS8-MEF2B,CACNA1D,FXYD2,SLC25A31,CNGA1,ADCY1,MYLK4,MYH7,INSR,PLCB4,PPP3CB,GNAI3,PRKG2,PPP3CC,PRKG1,EDNRB,RGS2,AKT3,MYLK3,CACNA1C,AKT2,KCNMA1,ATP1B3,ATP1A3,CACNA1S,ATP2A3,KCNJ8,CALML5,VASP,GNA12,VDAC1,PPP3R1,ADRA1B,MAP2K2,MEF2B,MAPK1,AGTR1,SLC8A1,PDE5A,CALM2,GATA4,MYLK,ITPR2,CREB3L2,CALML3,INS,SLC25A4,CALML6,CALM3,NOS3,MEF2A,ATF6B,ADRA2C,CREB3L1,PDE3A,MYLK2,ADCY8,NPR2,ATP1A4,GTF2IRD1,GTF2I,BDKRB2,PPP3R2,ATP2A2,MAPK3,MAP2K1,SRF,IRAG1,PDE2A,GNAQ,ATP2A1,ATP2B1,IRS2,CREB3,ADRB3,TRPC6,PLCB3,RAF1,ADRB1,CALML4,GNAI2,KCNMB1,PPP1CC,ADRA1A,GNA11,ADRA2A,ATF4,NPPB,ADORA3,PRKCE,KCNMB3,RHOA,NFATC1,NFATC2,ATP2B4,EDNRA,ITPR1,AKT1,PPP1R12A,ATP1B2,CREB5,ATP1A2,ROCK2,ADCY5
ko04022	cGMP-PKG signaling pathway	0.00151571631473768	-6.49186713675423	163	155	0.0246031746031746	6300	7161	3779,5501,468,150,2767,148,140,4879,5581,4773,4772,387,27094,3708,1909,493,9475,477,9586,482,207,4659,111,10335,5138,2776,490,487,10488,8660,5331,7225,155,153,5894,2771,91860,810,163688,808,291,3630,90993,152,1388,4846,4205,85366,5139,4882,114,624,2969,9569,480,5595,5604,488,5535,6722,10000,775,91807,489,779,478,483,3778,208,7408,51806,3764,2768,5605,5594,100271849,7416,147,5534,2626,805,8654,185,6546,64764,3709,4638,486,776,83447,4625,1259,107,340156,3643,5332,1910,5592,5533,5532,2773,5593,5997,23533,4209,134,23236,2983,2982,154,4776,801,5140,481,10242,476,1386,112,84699,10105,4207,5499,113,6543,157855,148327,1385,115,4208,491,109,10398,5330,27345,4775,5530,2770,3667,5350,146,2977,151,7419,1258,5500,5294,4985,146850,3710,6547,10672,196883,4881,7417,108	KCNMB1,PPP1CC,ATF4,ADRA2A,GNA11,ADRA1A,ADORA3,NPPB,PRKCE,NFATC2,NFATC1,RHOA,KCNMB3,ITPR1,EDNRA,ATP2B4,ROCK2,ATP1A2,CREB5,ATP1B2,AKT1,PPP1R12A,ADCY5,IRAG1,PDE2A,GNAQ,ATP2B1,ATP2A1,CREB3,IRS2,PLCB3,TRPC6,ADRB3,ADRB1,RAF1,GNAI2,CALML4,CALML3,CALML6,CALM3,SLC25A4,INS,CREB3L1,ADRA2C,ATF6B,NOS3,MEF2A,MYLK2,PDE3A,NPR2,ADCY8,BDKRB2,GTF2I,GTF2IRD1,ATP1A4,MAPK3,MAP2K1,ATP2A2,PPP3R2,SRF,AKT3,CACNA1C,MYLK3,ATP2A3,CACNA1S,ATP1A3,ATP1B3,KCNMA1,AKT2,VASP,CALML5,KCNJ8,GNA12,MAP2K2,MAPK1,MEF2B,VDAC1,ADRA1B,PPP3R1,GATA4,CALM2,PDE5A,AGTR1,SLC8A1,CREB3L2,ITPR2,MYLK,FXYD2,CACNA1D,SLC25A31,MYH7,CNGA1,ADCY1,MYLK4,INSR,PLCB4,EDNRB,PRKG1,PPP3CC,PPP3CB,GNAI3,PRKG2,RGS2,PIK3R5,MEF2D,ADORA1,PLCB1,GUCY1B1,GUCY1A1,ADRB2,NFATC4,CALM1,PDE3B,ATP1B1,KCNMB2,ATP1A1,ATF2,ADCY6,CREB3L3,PPIF,BORCS8-MEF2B,PPP1CA,ADCY7,SLC8A2,KCNU1,CREB3L4,CREB1,ADCY9,MEF2C,ATP2B2,ADCY3,MYL9,PLCB2,KCNMB4,NFATC3,PPP3CA,GNAI1,IRS1,PLN,ADRA1D,GUCY1A2,ADRA2B,VDAC3,CNGB1,PPP1CB,PIK3CG,OPRD1,PIK3R6,ITPR3,SLC8A3,GNA13,ADCY4,NPR1,VDAC2,ADCY2
ko04350	TGF-beta signaling pathway	0.00157591807140757	-6.4529172740452	84	82	0.013015873015873	6300	7161	269,130399,1387,9241,91,7048,83729,7040,8646,656,25805,3399,90,3625,4681,652,4088,4609,5933,7027,6500,4838,392255,57154,9978,7050,4090,3624,657,6667,151449,7044,387,353500,268,5515,5518,64750,1030,6199,7042,4091,7043,7124,1875,5516,5594,5519,658,8200,5308,6198,650,3400,8454,92,5595,4093,659,4092,653,100532736,9372,3398,4087,2033,10637,1874,7057,3458,4086,655,4052,93,3626,60436,10468,654,1634,4089,9765,7046	AMHR2,ACVR1C,CREBBP,NOG,ACVR1B,TGFBR2,INHBE,TGFB1,CHRD,BMP8B,BAMBI,ID3,ACVR1,INHBB,NBL1,BMP4,SMAD3,MYC,RBL1,TFDP1,SKP1,NODAL,GDF6,SMURF1,RBX1,TGIF1,SMAD5,INHBA,BMPR1A,SP1,GDF7,LEFTY2,RHOA,BMP8A,AMH,PPP2CA,PPP2R1A,SMURF2,CDKN2B,RPS6KB2,TGFB2,SMAD6,TGFB3,TNF,E2F5,PPP2CB,MAPK1,PPP2R1B,BMPR1B,GDF5,PITX2,RPS6KB1,BMP2,ID4,CUL1,ACVR2A,MAPK3,SMAD9,BMPR2,SMAD7,BMP5,MICOS10-NBL1,ZFYVE9,ID2,SMAD2,EP300,LEFTY1,E2F4,THBS1,IFNG,SMAD1,BMP7,LTBP1,ACVR2B,INHBC,TGIF2,FST,BMP6,DCN,SMAD4,ZFYVE16,TGFBR1
hsa04350	TGF-beta signaling pathway	0.00157591807140757	-6.4529172740452	84	82	0.013015873015873	6300	7161	7042,4091,7043,5516,7124,1875,5594,5308,8200,6198,5519,658,650,3400,8454,9372,3398,4087,659,5595,4093,92,100532736,653,4092,3458,4086,655,4052,1874,2033,10637,7057,654,1634,10468,93,60436,3626,9765,4089,7046,130399,269,1387,9241,91,7040,83729,7048,3399,90,3625,8646,656,25805,7027,6500,4681,652,4088,4609,5933,9978,7050,392255,4838,57154,151449,6667,4090,3624,657,7044,353500,387,268,64750,6199,1030,5515,5518	TGFB2,SMAD6,TGFB3,PPP2CB,TNF,E2F5,MAPK1,PITX2,GDF5,RPS6KB1,PPP2R1B,BMPR1B,BMP2,ID4,CUL1,ZFYVE9,ID2,SMAD2,BMPR2,MAPK3,SMAD9,ACVR2A,MICOS10-NBL1,BMP5,SMAD7,IFNG,SMAD1,BMP7,LTBP1,E2F4,EP300,LEFTY1,THBS1,BMP6,DCN,FST,ACVR2B,TGIF2,INHBC,ZFYVE16,SMAD4,TGFBR1,ACVR1C,AMHR2,CREBBP,NOG,ACVR1B,TGFB1,INHBE,TGFBR2,ID3,ACVR1,INHBB,CHRD,BMP8B,BAMBI,TFDP1,SKP1,NBL1,BMP4,SMAD3,MYC,RBL1,RBX1,TGIF1,GDF6,NODAL,SMURF1,GDF7,SP1,SMAD5,INHBA,BMPR1A,LEFTY2,BMP8A,RHOA,AMH,SMURF2,RPS6KB2,CDKN2B,PPP2CA,PPP2R1A
ko04915	Estrogen signaling pathway	0.00164722597182851	-6.40866263511631	98	95	0.0150793650793651	6300	7161	111,207,6714,9586,2885,3708,3845,468,5293,9568,91860,2771,399694,5894,5331,5568,10488,3320,2289,2776,2100,6464,5604,5595,1839,114,2288,4846,1388,90993,808,5567,163688,5290,3765,810,64764,3709,805,2099,5605,5594,53358,51806,4988,208,10000,4893,6667,3306,2773,5332,107,6655,3310,3762,3763,4318,5296,84699,112,1386,8503,1956,801,3265,5291,23236,2353,6654,2778,2770,25759,3725,3326,5330,3304,109,5566,115,1385,148327,3312,113,5295,3760,4313,108,196883,3710,2550,2911,5580,2852,3305	ADCY5,AKT1,SRC,CREB5,GRB2,ITPR1,KRAS,ATF4,PIK3CD,GABBR2,CALML4,GNAI2,SHC4,RAF1,PLCB3,PRKACG,CREB3,HSP90AA1,FKBP5,GNAQ,ESR2,SHC1,MAP2K1,MAPK3,HBEGF,ADCY8,FKBP4,NOS3,ATF6B,CREB3L1,CALM3,PRKACB,CALML6,PIK3CA,KCNJ9,CALML3,CREB3L2,ITPR2,CALM2,ESR1,MAP2K2,MAPK1,SHC3,CALML5,OPRM1,AKT2,AKT3,NRAS,SP1,HSPA2,GNAI3,PLCB4,ADCY1,SOS2,HSPA6,KCNJ5,KCNJ6,MMP9,PIK3R2,CREB3L3,ADCY6,ATF2,PIK3R3,EGFR,CALM1,HRAS,PIK3CB,PLCB1,FOS,SOS1,GNAS,GNAI1,SHC2,JUN,HSP90AB1,PLCB2,HSPA1B,ADCY3,PRKACA,ADCY9,CREB1,CREB3L4,HSPA8,ADCY7,PIK3R1,KCNJ3,MMP2,ADCY2,ADCY4,ITPR3,GABBR1,GRM1,PRKCD,GPER1,HSPA1L
hsa04915	Estrogen signaling pathway	0.00164722597182851	-6.40866263511631	98	95	0.0150793650793651	6300	7161	3710,196883,108,4313,3305,2852,2550,2911,5580,3326,5330,3725,25759,2778,2770,5295,3760,3312,148327,113,1385,115,109,3304,5566,1956,1386,8503,112,84699,5296,4318,2353,6654,5291,3265,23236,801,5332,2773,3306,6667,3763,3762,3310,107,6655,53358,5605,5594,2099,805,3709,64764,10000,4893,208,51806,4988,114,1839,6464,5604,5595,5290,3765,810,163688,808,5567,4846,90993,1388,2288,5568,10488,5331,5894,9568,2771,399694,91860,2776,2289,2100,3320,3708,9586,6714,207,2885,111,5293,468,3845	ITPR3,ADCY4,ADCY2,MMP2,HSPA1L,GPER1,GABBR1,GRM1,PRKCD,HSP90AB1,PLCB2,JUN,SHC2,GNAS,GNAI1,PIK3R1,KCNJ3,HSPA8,CREB3L4,ADCY7,CREB1,ADCY9,ADCY3,HSPA1B,PRKACA,EGFR,ATF2,PIK3R3,ADCY6,CREB3L3,PIK3R2,MMP9,FOS,SOS1,PIK3CB,HRAS,PLCB1,CALM1,PLCB4,GNAI3,HSPA2,SP1,KCNJ6,KCNJ5,HSPA6,ADCY1,SOS2,SHC3,MAP2K2,MAPK1,ESR1,CALM2,ITPR2,CREB3L2,AKT3,NRAS,AKT2,CALML5,OPRM1,ADCY8,HBEGF,SHC1,MAP2K1,MAPK3,PIK3CA,KCNJ9,CALML3,CALML6,CALM3,PRKACB,NOS3,CREB3L1,ATF6B,FKBP4,PRKACG,CREB3,PLCB3,RAF1,GABBR2,GNAI2,SHC4,CALML4,GNAQ,FKBP5,ESR2,HSP90AA1,ITPR1,CREB5,SRC,AKT1,GRB2,ADCY5,PIK3CD,ATF4,KRAS
hsa04972	Pancreatic secretion	0.00222788342641393	-6.10670328036228	95	92	0.0146031746031746	6300	7161	5644,5579,3710,196883,84647,108,1504,5322,5408,952,5330,279,5908,2778,280,9545,113,50487,115,491,109,1506,51032,481,476,81579,1080,3784,112,7220,5879,5646,5320,8766,22802,23236,1179,30814,5582,5332,1360,5578,391013,5407,486,6548,107,1358,1361,1056,5874,3709,8671,5319,10136,489,219931,478,483,1131,3778,114,480,488,23436,9635,5331,760,6262,6522,6344,2776,886,490,487,5906,64600,4218,387,5406,3708,683,493,477,482,1359,63036,6558,111,1357,1811,26279	PRSS1,PRKCB,ITPR3,ADCY4,PLA2G12B,ADCY2,CTRB1,PLA2G5,PNLIPRP2,CD38,PLCB2,AMY2A,RAP1B,GNAS,AMY2B,RAB3D,ADCY7,PLA2G3,ADCY9,ATP2B2,ADCY3,CTRL,CELA2B,ATP1B1,ATP1A1,PLA2G12A,CFTR,KCNQ1,ADCY6,TRPC1,RAC1,PRSS3,PLA2G2A,RAB11A,CLCA4,PLCB1,CLCA1,PLA2G2E,PRKCG,PLCB4,CPB1,PRKCA,PLA2G2C,PNLIPRP1,FXYD2,SLC9A1,ADCY1,CPA2,CPB2,CEL,RAB27B,ITPR2,SLC4A4,PLA2G1B,CELA3A,ATP2A3,TPCN2,ATP1A3,ATP1B3,CHRM3,KCNMA1,ADCY8,ATP1A4,ATP2A2,CELA3B,CLCA2,PLCB3,CA2,RYR2,SLC4A2,SCTR,GNAQ,CCKAR,ATP2B1,ATP2A1,RAP1A,PLA2G2F,RAB8A,RHOA,PNLIP,ITPR1,BST1,ATP2B4,ATP1A2,ATP1B2,CPA3,CELA2A,SLC12A2,ADCY5,CPA1,SLC26A3,PLA2G2D
ko04972	Pancreatic secretion	0.00222788342641393	-6.10670328036228	95	92	0.0146031746031746	6300	7161	5331,760,6344,6522,6262,886,2776,5906,487,490,4218,64600,387,493,683,5406,3708,482,477,6558,111,63036,1359,1811,1357,26279,1361,1056,1358,5874,8671,3709,5319,10136,1131,3778,483,478,489,219931,114,480,488,23436,9635,81579,476,481,51032,1506,7220,112,3784,1080,5879,5320,8766,5646,1179,23236,22802,30814,5582,1360,5332,5578,5407,391013,486,6548,107,3710,5579,5644,196883,108,84647,1504,5322,5408,952,279,5330,5908,2778,280,9545,50487,113,115,109,491	PLCB3,CA2,SCTR,SLC4A2,RYR2,CCKAR,GNAQ,RAP1A,ATP2A1,ATP2B1,RAB8A,PLA2G2F,RHOA,ATP2B4,BST1,PNLIP,ITPR1,ATP1B2,ATP1A2,SLC12A2,ADCY5,CELA2A,CPA3,SLC26A3,CPA1,PLA2G2D,CPB2,CEL,CPA2,RAB27B,SLC4A4,ITPR2,PLA2G1B,CELA3A,CHRM3,KCNMA1,ATP1B3,ATP1A3,ATP2A3,TPCN2,ADCY8,ATP1A4,ATP2A2,CELA3B,CLCA2,PLA2G12A,ATP1A1,ATP1B1,CELA2B,CTRL,TRPC1,ADCY6,KCNQ1,CFTR,RAC1,PLA2G2A,RAB11A,PRSS3,CLCA1,PLCB1,CLCA4,PLA2G2E,PRKCG,CPB1,PLCB4,PRKCA,PNLIPRP1,PLA2G2C,FXYD2,SLC9A1,ADCY1,ITPR3,PRKCB,PRSS1,ADCY4,ADCY2,PLA2G12B,CTRB1,PLA2G5,PNLIPRP2,CD38,AMY2A,PLCB2,RAP1B,GNAS,AMY2B,RAB3D,PLA2G3,ADCY7,ADCY9,ADCY3,ATP2B2
hsa04924	Renin secretion	0.00231945958043812	-6.06642105990486	65	64	0.0101587301587302	6300	7161	2778,2770,5136,5535,5530,5137,5330,1385,5566,1508,5139,3759,810,9635,163688,5567,808,805,84876,185,3709,3710,5534,4881,183,5153,779,5972,3778,51806,2977,775,5732,5593,5532,2773,5533,1636,111,5332,1909,3708,5734,776,117,153,91860,2771,5140,5568,5331,155,112,358,154,801,116,2982,23236,2983,22802,134,2776,1179	GNAS,GNAI1,PDE1A,PPP3R2,PPP3CA,PDE1C,PLCB2,CREB1,PRKACA,CTSB,PDE3A,KCNJ2,CALML3,CLCA2,CALML6,PRKACB,CALM3,CALM2,ORAI1,AGTR1,ITPR2,ITPR3,PPP3R1,NPR1,AGT,PDE1B,CACNA1S,REN,KCNMA1,CALML5,GUCY1A2,CACNA1C,PTGER2,PRKG2,PPP3CB,GNAI3,PPP3CC,ACE,ADCY5,PLCB4,EDNRA,ITPR1,PTGER4,CACNA1D,ADCYAP1R1,ADRB1,CALML4,GNAI2,PDE3B,PRKACG,PLCB3,ADRB3,ADCY6,AQP1,ADRB2,CALM1,ADCYAP1,GUCY1A1,PLCB1,GUCY1B1,CLCA4,ADORA1,GNAQ,CLCA1
ko04924	Renin secretion	0.00231945958043812	-6.06642105990486	65	64	0.0101587301587302	6300	7161	5533,5532,2773,5593,1636,111,5332,3708,1909,5734,776,117,153,2771,91860,5568,5140,155,112,5331,116,801,154,358,1179,2776,2983,23236,134,22802,2982,5530,5136,2778,2770,5535,5137,5330,1385,3759,1508,5139,5566,810,5567,808,163688,9635,185,805,84876,3709,3710,183,4881,5534,3778,5972,779,5153,51806,2977,5732,775	PPP3CC,PPP3CB,GNAI3,PRKG2,ACE,ADCY5,PLCB4,ITPR1,EDNRA,PTGER4,CACNA1D,ADCYAP1R1,ADRB1,GNAI2,CALML4,PRKACG,PDE3B,ADRB3,ADCY6,PLCB3,ADCYAP1,CALM1,ADRB2,AQP1,CLCA1,GNAQ,GUCY1B1,PLCB1,ADORA1,CLCA4,GUCY1A1,PPP3CA,PDE1A,GNAS,GNAI1,PPP3R2,PDE1C,PLCB2,CREB1,KCNJ2,CTSB,PDE3A,PRKACA,CALML3,PRKACB,CALM3,CALML6,CLCA2,AGTR1,CALM2,ORAI1,ITPR2,ITPR3,AGT,NPR1,PPP3R1,KCNMA1,REN,CACNA1S,PDE1B,CALML5,GUCY1A2,PTGER2,CACNA1C
hsa04270	Vascular smooth muscle contraction	0.00232302516096991	-6.06488499401278	121	116	0.0184126984126984	6300	7161	5320,23236,2983,2982,5583,5582,30814,801,10242,81579,112,5499,776,140465,107,340156,553,5332,4660,5578,5592,54776,391013,552,2977,5322,5500,5580,255189,5588,5579,3710,10672,23365,196883,10203,4881,283748,59,84647,108,8398,113,50487,157855,115,5739,5566,109,100137049,10398,5330,27345,72,136,2778,146,10335,673,2776,10268,9138,64600,5568,5331,5894,91860,135,94274,5501,3779,2767,148,4637,26279,5581,387,27094,3708,1909,9826,9475,4659,111,5319,775,8605,4629,91807,779,3778,51806,10266,2768,10267,5605,5594,147,284541,805,185,3709,4638,810,5567,163688,808,5321,800,85366,4882,114,123745,5595,5604,1579	PLA2G2A,PLCB1,GUCY1B1,GUCY1A1,PRKCH,PRKCG,PLA2G2E,CALM1,KCNMB2,PLA2G12A,ADCY6,PPP1CA,CACNA1D,MYL6B,ADCY1,MYLK4,AVPR1B,PLCB4,PPP1R12B,PRKCA,PRKG1,PPP1R12C,PLA2G2C,AVPR1A,GUCY1A2,PLA2G5,PPP1CB,PRKCD,PLA2G4F,PRKCQ,PRKCB,ITPR3,GNA13,ARHGEF12,ADCY4,CALCRL,NPR1,PLA2G4D,ACTA2,PLA2G12B,ADCY2,PLA2G6,ADCY7,PLA2G3,KCNU1,ADCY9,PTGIR,PRKACA,ADCY3,PLA2G4B,MYL9,PLCB2,KCNMB4,ACTG2,ADORA2B,GNAS,ADRA1D,IRAG1,BRAF,GNAQ,RAMP3,ARHGEF1,PLA2G2F,PRKACG,PLCB3,RAF1,CALML4,ADORA2A,PPP1R14A,PPP1CC,KCNMB1,GNA11,ADRA1A,MYL6,PLA2G2D,PRKCE,RHOA,KCNMB3,ITPR1,EDNRA,ARHGEF11,ROCK2,PPP1R12A,ADCY5,PLA2G1B,CACNA1C,PLA2G4C,MYH11,MYLK3,CACNA1S,KCNMA1,CALML5,RAMP2,GNA12,RAMP1,MAP2K2,MAPK1,ADRA1B,CYP4A22,CALM2,AGTR1,ITPR2,MYLK,CALML3,PRKACB,CALML6,CALM3,PLA2G4A,CALD1,MYLK2,NPR2,ADCY8,PLA2G4E,MAPK3,MAP2K1,CYP4A11
ko04270	Vascular smooth muscle contraction	0.00232302516096991	-6.06488499401278	121	116	0.0184126984126984	6300	7161	5330,27345,72,146,136,2778,113,50487,157855,8398,5739,5566,109,100137049,10398,115,196883,23365,10203,4881,5579,3710,10672,59,84647,108,283748,5500,552,5322,2977,5580,255189,5588,4660,553,5332,391013,5578,5592,54776,140465,776,340156,107,112,10242,81579,5499,2983,23236,2982,5320,801,5583,5582,30814,4882,114,123745,5595,5604,1579,163688,808,5567,5321,810,85366,800,5605,5594,10267,147,10266,2768,3709,4638,284541,805,185,775,8605,4629,91807,5319,51806,779,3778,3708,1909,9826,387,27094,111,9475,4659,2767,148,94274,3779,5501,5581,26279,4637,5331,5568,91860,135,5894,673,2776,10335,64600,10268,9138	PLCB2,KCNMB4,ACTG2,ADRA1D,ADORA2B,GNAS,ADCY7,PLA2G3,KCNU1,PLA2G6,PTGIR,PRKACA,ADCY3,PLA2G4B,MYL9,ADCY9,ADCY4,ARHGEF12,CALCRL,NPR1,PRKCB,ITPR3,GNA13,ACTA2,PLA2G12B,ADCY2,PLA2G4D,PPP1CB,AVPR1A,PLA2G5,GUCY1A2,PRKCD,PLA2G4F,PRKCQ,PPP1R12B,AVPR1B,PLCB4,PLA2G2C,PRKCA,PRKG1,PPP1R12C,MYL6B,CACNA1D,MYLK4,ADCY1,ADCY6,KCNMB2,PLA2G12A,PPP1CA,GUCY1B1,PLCB1,GUCY1A1,PLA2G2A,CALM1,PRKCH,PRKCG,PLA2G2E,NPR2,ADCY8,PLA2G4E,MAPK3,MAP2K1,CYP4A11,CALML6,CALM3,PRKACB,PLA2G4A,CALML3,MYLK2,CALD1,MAP2K2,MAPK1,RAMP1,ADRA1B,RAMP2,GNA12,ITPR2,MYLK,CYP4A22,CALM2,AGTR1,CACNA1C,PLA2G4C,MYH11,MYLK3,PLA2G1B,CALML5,CACNA1S,KCNMA1,ITPR1,EDNRA,ARHGEF11,RHOA,KCNMB3,ADCY5,ROCK2,PPP1R12A,GNA11,ADRA1A,PPP1R14A,KCNMB1,PPP1CC,PRKCE,PLA2G2D,MYL6,PLCB3,PRKACG,CALML4,ADORA2A,RAF1,BRAF,GNAQ,IRAG1,PLA2G2F,RAMP3,ARHGEF1
hsa04072	Phospholipase D signaling pathway	0.00248623783383439	-5.9969846211879	145	138	0.0219047619047619	6300	7161	22800,5898,3643,5332,553,5578,5154,9162,107,6655,2915,8503,112,11069,1956,6009,8877,2206,1785,5296,5291,5337,3265,23236,23533,2914,26052,6654,1606,160851,2185,5155,10411,5156,5900,5737,9267,5338,5330,25759,2778,113,5295,2205,109,100137049,8527,115,196883,2916,10672,9846,6237,10161,108,23396,5899,283748,2149,8611,55326,552,5294,146850,255189,2911,3576,387,111,2549,207,2885,80310,5293,3845,2918,2207,1609,5331,1902,399694,5894,7249,8525,9265,382,27128,5336,1607,2475,4254,114,7248,6850,123745,5335,1608,9266,6464,5595,5604,8526,5321,3630,5159,8613,8395,8612,5290,3815,2912,1950,2913,56894,2534,551,5605,5594,56848,56895,53358,2768,5781,3579,185,2917,23566,8605,57121,10000,3577,4893,8394,375,22808,208,56034,1759	RRAS2,RALA,INSR,PLCB4,AVPR1B,PRKCA,PDGFA,DGKI,ADCY1,SOS2,GRM5,PIK3R3,ADCY6,RAPGEF4,EGFR,RHEB,SPHK1,MS4A2,DNM2,PIK3R2,PIK3CB,PLD1,HRAS,PLCB1,PIK3R5,GRM4,DNM3,SOS1,DGKA,DGKH,PTK2B,PDGFB,RAPGEF3,PDGFRA,RALGDS,PTGFR,CYTH1,PLD2,PLCB2,SHC2,GNAS,ADCY7,PIK3R1,FCER1A,ADCY3,PLA2G4B,DGKD,ADCY9,ADCY4,GRM6,GNA13,GAB2,RRAS,LPAR6,ADCY2,PIP5K1C,RALB,PLA2G4D,F2R,PLPP1,AGPAT5,AVPR1A,PIK3CG,PIK3R6,PLA2G4F,GRM1,CXCL8,RHOA,ADCY5,GAB1,AKT1,GRB2,PDGFD,PIK3CD,KRAS,GRM8,FCER1G,DGKQ,PLCB3,LPAR1,SHC4,RAF1,TSC2,DGKZ,CYTH3,ARF6,CYTH4,PLCG2,DGKB,MTOR,KITLG,ADCY8,TSC1,SYK,PLA2G4E,PLCG1,DGKG,CYTH2,SHC1,MAPK3,MAP2K1,DGKE,PLA2G4A,INS,PDGFRB,PLPP3,PIP5K1B,PLPP2,PIK3CA,KIT,GRM2,EGF,GRM3,AGPAT3,FYN,AVP,MAP2K2,MAPK1,SPHK2,AGPAT4,SHC3,GNA12,PTPN11,CXCR2,AGTR1,GRM7,LPAR3,PLA2G4C,LPAR5,AKT3,CXCR1,NRAS,PIP5K1A,ARF1,MRAS,AKT2,PDGFC,DNM1
ko04072	Phospholipase D signaling pathway	0.00248623783383439	-5.9969846211879	145	138	0.0219047619047619	6300	7161	3576,255189,2911,146850,5294,552,55326,8611,2149,283748,23396,5899,108,6237,10161,9846,10672,2916,196883,115,100137049,8527,109,2205,5295,113,2778,25759,5330,5338,9267,5737,5900,5156,10411,5155,2185,1606,160851,6654,26052,2914,23533,23236,3265,5291,5337,5296,1785,2206,1956,6009,8877,11069,112,8503,2915,6655,107,9162,5154,5578,553,5332,3643,5898,22800,1759,56034,208,22808,375,8394,4893,3577,10000,57121,8605,23566,2917,185,3579,5781,2768,53358,56895,56848,5594,5605,551,2534,56894,2913,1950,2912,3815,8612,5290,8395,8613,5159,3630,5321,8526,5595,5604,6464,9266,1608,5335,6850,123745,114,7248,4254,2475,1607,5336,27128,382,9265,8525,7249,5894,399694,1902,5331,2207,1609,2918,3845,5293,80310,2885,207,2549,111,387	CXCL8,PLA2G4F,GRM1,PIK3R6,PIK3CG,AVPR1A,AGPAT5,PLPP1,F2R,PLA2G4D,PIP5K1C,RALB,ADCY2,RRAS,LPAR6,GAB2,GNA13,GRM6,ADCY4,ADCY9,PLA2G4B,DGKD,ADCY3,FCER1A,PIK3R1,ADCY7,GNAS,SHC2,PLCB2,PLD2,CYTH1,PTGFR,RALGDS,PDGFRA,RAPGEF3,PDGFB,PTK2B,DGKA,DGKH,SOS1,DNM3,GRM4,PIK3R5,PLCB1,HRAS,PIK3CB,PLD1,PIK3R2,DNM2,MS4A2,EGFR,RHEB,SPHK1,RAPGEF4,ADCY6,PIK3R3,GRM5,SOS2,ADCY1,DGKI,PDGFA,PRKCA,AVPR1B,PLCB4,INSR,RALA,RRAS2,DNM1,PDGFC,AKT2,MRAS,ARF1,PIP5K1A,NRAS,CXCR1,AKT3,LPAR5,PLA2G4C,LPAR3,GRM7,AGTR1,CXCR2,PTPN11,GNA12,SHC3,AGPAT4,SPHK2,MAPK1,MAP2K2,AVP,FYN,AGPAT3,GRM3,EGF,GRM2,KIT,PLPP2,PIK3CA,PIP5K1B,PLPP3,PDGFRB,INS,PLA2G4A,DGKE,MAPK3,MAP2K1,SHC1,CYTH2,DGKG,PLCG1,SYK,PLA2G4E,ADCY8,TSC1,KITLG,MTOR,DGKB,PLCG2,CYTH4,ARF6,CYTH3,DGKZ,TSC2,RAF1,SHC4,LPAR1,PLCB3,FCER1G,DGKQ,GRM8,KRAS,PIK3CD,PDGFD,GRB2,AKT1,GAB1,ADCY5,RHOA
hsa05214	Glioma	0.00260279135037194	-5.95117081355016	64	63	0.01	6300	7161	1956,1019,8503,5894,1869,817,5296,399694,91860,6654,5291,3265,673,5155,5582,2475,5336,801,595,1021,816,207,5578,1871,2885,5925,1029,5293,5154,1026,6655,3845,3479,815,53358,5579,5605,5594,805,1870,10000,4893,208,3480,51806,4193,5335,5728,5156,6464,7157,5604,25759,5595,7039,5295,5159,5290,810,808,163688,818,1950	EGFR,CDK4,PIK3R3,RAF1,E2F1,CAMK2D,PIK3R2,SHC4,CALML4,SOS1,PIK3CB,HRAS,BRAF,PDGFB,PRKCG,MTOR,PLCG2,CALM1,CCND1,CDK6,CAMK2B,AKT1,PRKCA,E2F3,GRB2,RB1,CDKN2A,PIK3CD,PDGFA,CDKN1A,SOS2,KRAS,IGF1,CAMK2A,SHC3,PRKCB,MAP2K2,MAPK1,CALM2,E2F2,AKT3,NRAS,AKT2,IGF1R,CALML5,MDM2,PLCG1,PTEN,PDGFRA,SHC1,TP53,MAP2K1,SHC2,MAPK3,TGFA,PIK3R1,PDGFRB,PIK3CA,CALML3,CALM3,CALML6,CAMK2G,EGF
ko05214	Glioma	0.00260279135037194	-5.95117081355016	64	63	0.01	6300	7161	5296,399694,91860,1869,817,5894,8503,1019,1956,595,5336,801,2475,5155,5582,673,5291,3265,6654,1029,2885,1871,5578,5925,207,816,1021,3845,6655,1026,5154,5293,1870,805,5594,5605,5579,815,3479,53358,51806,3480,208,4893,10000,5604,25759,5595,6464,7157,5156,5728,5335,4193,818,1950,808,163688,810,5295,5159,7039,5290	PIK3R2,SHC4,CALML4,E2F1,CAMK2D,RAF1,PIK3R3,CDK4,EGFR,CCND1,PLCG2,CALM1,MTOR,PDGFB,PRKCG,BRAF,PIK3CB,HRAS,SOS1,CDKN2A,GRB2,E2F3,PRKCA,RB1,AKT1,CAMK2B,CDK6,KRAS,SOS2,CDKN1A,PDGFA,PIK3CD,E2F2,CALM2,MAPK1,MAP2K2,PRKCB,CAMK2A,IGF1,SHC3,CALML5,IGF1R,AKT2,NRAS,AKT3,MAP2K1,SHC2,MAPK3,SHC1,TP53,PDGFRA,PTEN,PLCG1,MDM2,CAMK2G,EGF,CALM3,CALML6,CALML3,PIK3R1,PDGFRB,TGFA,PIK3CA
hsa05166	HTLV-I infection	0.00282272141626376	-5.87005381815675	256	239	0.0379365079365079	6300	7161	4605,5295,7046,113,7484,6776,3569,5156,3725,7157,4087,7419,10297,3718,8323,8322,4791,3109,108,6237,4214,64784,5154,7481,7475,51529,22800,3108,1871,5532,5533,3601,8829,29945,7855,2353,5970,4776,958,1855,81029,9184,112,1386,3560,1869,5290,11211,2874,291,57804,8326,4792,4488,114,2033,8321,6777,896,3558,94241,6722,1031,89780,10000,1739,4049,208,22808,3118,54361,467,5534,991,1390,7479,7043,7042,200186,80326,1026,706,83660,324,4772,4773,7478,1499,3105,10524,5925,3119,111,7850,8324,3689,64682,7483,917,7482,3135,4609,7514,3383,51434,8061,5568,3559,6416,1387,821,4089,8498,115,1385,7412,5566,1856,109,5427,8295,4775,7976,5530,466,3107,7132,5423,3133,10393,7476,7015,51433,3554,196883,7471,4801,51384,7494,10714,7417,2113,83447,1030,8850,6513,916,107,598,545,2932,5902,3111,3123,3122,23373,387332,1029,2224,811,3265,5291,4088,5155,3127,595,8697,2005,4215,1111,5599,8503,10744,7474,5296,3551,5159,5567,996,56655,1857,1958,5971,7473,7472,9020,5535,7538,4893,7480,7477,2535,9519,3106,9133,915,1147,2114,54107,7416,3600,1870,7124,5293,4603,4602,3117,468,581,3134,115650,5424,1437,3845,9232,3716,4790,4055,5111,207,55697,11200,4487,894,3932,1959,472,4085,3113,3112,5901,8325,6688,3683,1019,701,6929,7040,7048	MYBL2,PIK3R1,TGFBR1,ADCY7,WNT9B,STAT5A,IL6,PDGFRA,JUN,TP53,SMAD2,VDAC3,APC2,JAK3,FZD6,FZD4,NFKB2,HLA-DMB,ADCY2,RRAS,MAP3K1,CRTC3,PDGFA,WNT11,WNT6,ANAPC11,RRAS2,HLA-DMA,E2F3,PPP3CB,PPP3CC,IL15RA,NRP1,ANAPC4,FZD5,FOS,RELA,NFATC4,CD40,DVL1,WNT5B,BUB3,ADCY6,ATF2,IL2RB,E2F1,PIK3CA,FZD10,GPS2,SLC25A4,POLD4,FZD9,NFKBIA,MSX2,ADCY8,EP300,FZD1,STAT5B,CCND3,IL2,TP53INP1,SRF,CDKN2C,WNT3A,AKT3,DLG1,LTA,AKT2,MRAS,HLA-DQA2,WNT4,ATF3,PPP3R1,CDC20,CREM,WNT8B,TGFB3,TGFB2,CRTC2,WNT10A,CDKN1A,TSPO,TLN2,APC,NFATC1,NFATC2,WNT8A,CTNNB1,HLA-A,KAT5,RB1,HLA-DQB1,ADCY5,IL1R2,FZD7,ITGB2,ANAPC1,WNT9A,CD3G,WNT2B,HLA-G,MYC,XPO1,ICAM1,ANAPC7,FOSL1,PRKACG,IL2RA,MAP2K4,CREBBP,CANX,SMAD4,RANBP3,ADCY9,CREB1,VCAM1,PRKACA,DVL2,ADCY3,POLE2,TRRAP,NFATC3,FZD3,PPP3CA,ATF1,HLA-C,TNFRSF1A,POLB,HLA-E,ANAPC10,WNT7A,TERT,ANAPC5,IL1R1,ADCY4,WNT1,NFYB,WNT16,XBP1,POLD3,VDAC2,ETS1,SLC25A31,CDKN2B,KAT2B,SLC2A1,CD3E,ADCY1,BCL2L1,ATR,GSK3B,RANBP1,HLA-DOA,HLA-DRB1,HLA-DRA,CRTC1,TBPL2,CDKN2A,FDPS,CALR,HRAS,PIK3CB,SMAD3,PDGFB,HLA-DRB5,CCND1,CDC23,ELK4,MAP3K3,CHEK1,MAPK8,PIK3R3,PTTG2,WNT5A,PIK3R2,IKBKB,PDGFRB,PRKACB,CDC27,POLE4,DVL3,EGR1,RELB,WNT3,WNT2,MAP3K14,PPP3R2,ZFP36,NRAS,WNT10B,WNT7B,FZD2,TBPL1,HLA-B,CCNB2,CD3D,CHUK,ETS2,POLE3,VDAC1,IL15,E2F2,TNF,PIK3CD,MYBL1,MYB,HLA-DQA1,ATF4,BAX,HLA-F,TNFRSF13C,POLD1,CSF2,KRAS,PTTG1,JAK1,NFKB1,LTBR,PCNA,AKT1,VAC14,CHEK2,MSX1,CCND2,LCK,EGR2,ATM,MAD2L1,HLA-DPA1,HLA-DOB,RAN,FZD8,SPI1,ITGAL,CDK4,BUB1B,TCF3,TGFB1,TGFBR2
ko05166	HTLV-I infection	0.00282272141626376	-5.87005381815675	256	239	0.0379365079365079	6300	7161	3106,9133,2114,1147,915,7480,4893,9519,7477,2535,3600,1870,7124,54107,7416,1958,5971,5159,996,1857,56655,5567,5535,7538,9020,7473,7472,4085,472,3932,1959,55697,11200,4487,894,6929,701,7040,7048,6688,3113,3112,5901,8325,1019,3683,1437,5424,3716,3845,9232,4603,4602,5293,3134,115650,3117,581,468,207,5111,4790,4055,3133,10393,7476,7132,3107,5423,51384,4801,7417,7494,10714,51433,7015,196883,7471,3554,7412,115,1385,1856,109,5566,4089,821,8498,5530,466,4775,7976,5427,8295,4088,5155,2005,4215,3127,595,8697,2224,3265,5291,811,3551,7474,5296,1111,5599,10744,8503,6513,8850,916,107,2113,83447,1030,23373,3123,3122,387332,1029,545,598,3111,5902,2932,208,22808,10000,1031,89780,1739,4049,7479,1390,7043,7042,3118,5534,991,467,54361,57804,8326,5290,11211,291,2874,3558,94241,896,6777,6722,4488,2033,114,4792,8321,7514,3135,4609,51434,3383,7483,7482,917,6416,1387,3559,5568,8061,706,1026,83660,200186,80326,3119,5925,111,7850,3689,8324,64682,7478,4772,324,4773,10524,3105,1499,7419,10297,3109,108,6237,8323,8322,3718,4791,7484,5295,7046,4605,113,7157,3725,4087,6776,3569,5156,5970,958,4776,2353,1869,3560,1855,112,1386,81029,9184,64784,4214,7481,5154,5532,5533,1871,7855,8829,3601,29945,7475,3108,22800,51529	HLA-B,CCNB2,ETS2,CHUK,CD3D,WNT10B,NRAS,TBPL1,WNT7B,FZD2,IL15,E2F2,TNF,POLE3,VDAC1,EGR1,RELB,PDGFRB,CDC27,DVL3,POLE4,PRKACB,PPP3R2,ZFP36,MAP3K14,WNT3,WNT2,MAD2L1,ATM,LCK,EGR2,VAC14,CHEK2,MSX1,CCND2,TCF3,BUB1B,TGFB1,TGFBR2,SPI1,HLA-DPA1,HLA-DOB,RAN,FZD8,CDK4,ITGAL,CSF2,POLD1,JAK1,KRAS,PTTG1,MYBL1,MYB,PIK3CD,HLA-F,TNFRSF13C,HLA-DQA1,BAX,ATF4,AKT1,PCNA,NFKB1,LTBR,HLA-E,ANAPC10,WNT7A,TNFRSF1A,HLA-C,POLB,WNT16,NFYB,VDAC2,XBP1,POLD3,ANAPC5,TERT,ADCY4,WNT1,IL1R1,VCAM1,ADCY9,CREB1,DVL2,ADCY3,PRKACA,SMAD4,CANX,RANBP3,PPP3CA,ATF1,NFATC3,FZD3,POLE2,TRRAP,SMAD3,PDGFB,ELK4,MAP3K3,HLA-DRB5,CCND1,CDC23,FDPS,HRAS,PIK3CB,CALR,IKBKB,WNT5A,PIK3R2,CHEK1,MAPK8,PTTG2,PIK3R3,SLC2A1,KAT2B,CD3E,ADCY1,ETS1,SLC25A31,CDKN2B,CRTC1,HLA-DRB1,HLA-DRA,TBPL2,CDKN2A,ATR,BCL2L1,HLA-DOA,RANBP1,GSK3B,AKT2,MRAS,AKT3,CDKN2C,WNT3A,DLG1,LTA,WNT8B,CREM,TGFB3,TGFB2,HLA-DQA2,PPP3R1,CDC20,ATF3,WNT4,POLD4,FZD9,PIK3CA,FZD10,SLC25A4,GPS2,IL2,TP53INP1,CCND3,STAT5B,SRF,MSX2,EP300,ADCY8,NFKBIA,FZD1,XPO1,HLA-G,MYC,ANAPC7,ICAM1,WNT9A,WNT2B,CD3G,MAP2K4,CREBBP,IL2RA,PRKACG,FOSL1,TSPO,CDKN1A,TLN2,CRTC2,WNT10A,HLA-DQB1,RB1,ADCY5,IL1R2,ITGB2,FZD7,ANAPC1,WNT8A,NFATC1,APC,NFATC2,KAT5,HLA-A,CTNNB1,VDAC3,APC2,HLA-DMB,ADCY2,RRAS,FZD6,FZD4,JAK3,NFKB2,WNT9B,PIK3R1,TGFBR1,MYBL2,ADCY7,TP53,JUN,SMAD2,STAT5A,IL6,PDGFRA,RELA,CD40,NFATC4,FOS,E2F1,IL2RB,DVL1,ADCY6,ATF2,WNT5B,BUB3,CRTC3,MAP3K1,WNT11,PDGFA,PPP3CB,PPP3CC,E2F3,FZD5,NRP1,IL15RA,ANAPC4,WNT6,HLA-DMA,RRAS2,ANAPC11
hsa04912	GnRH signaling pathway	0.00300508133509729	-5.80745064477314	92	89	0.0141269841269841	6300	7161	5601,10746,3708,6714,2885,111,468,2767,5606,3845,5568,5331,5894,6416,817,1432,91860,2776,6300,114,123745,1081,4323,1839,5595,5604,810,5321,5567,808,163688,818,815,5605,5594,805,3709,4893,3972,2796,8605,775,779,51806,5332,816,5578,2798,5609,998,776,4214,6655,107,1956,5599,112,5602,5603,6654,5337,3265,23236,2185,4215,801,4216,5330,5338,2488,3725,5598,2778,113,115,109,100137049,5566,5579,3710,196883,5600,5608,283748,4313,108,5580,255189,2797	MAPK9,MAP3K2,ITPR1,SRC,GRB2,ADCY5,ATF4,GNA11,MAP2K3,KRAS,PRKACG,PLCB3,RAF1,MAP2K4,CAMK2D,MAPK14,CALML4,GNAQ,MAPK12,ADCY8,PLA2G4E,CGA,MMP14,HBEGF,MAPK3,MAP2K1,CALML3,PLA2G4A,PRKACB,CALM3,CALML6,CAMK2G,CAMK2A,MAP2K2,MAPK1,CALM2,ITPR2,NRAS,LHB,GNRH1,PLA2G4C,CACNA1C,CACNA1S,CALML5,PLCB4,CAMK2B,PRKCA,GNRHR,MAP2K7,CDC42,CACNA1D,MAP3K1,SOS2,ADCY1,EGFR,MAPK8,ADCY6,MAPK10,MAPK13,SOS1,PLD1,HRAS,PLCB1,PTK2B,MAP3K3,CALM1,MAP3K4,PLCB2,PLD2,FSHB,JUN,MAPK7,GNAS,ADCY7,ADCY9,ADCY3,PLA2G4B,PRKACA,PRKCB,ITPR3,ADCY4,MAPK11,MAP2K6,PLA2G4D,MMP2,ADCY2,PRKCD,PLA2G4F,GNRH2
ko04912	GnRH signaling pathway	0.00300508133509729	-5.80745064477314	92	89	0.0141269841269841	6300	7161	2797,255189,5580,108,4313,283748,5608,5600,196883,5579,3710,5566,100137049,109,115,113,2778,5598,3725,2488,5330,5338,4216,801,4215,2185,23236,3265,5337,6654,5603,5602,112,5599,1956,6655,107,4214,776,998,5609,5578,2798,816,5332,51806,779,8605,775,2796,3972,4893,3709,805,5594,5605,815,818,808,163688,5567,5321,810,5604,5595,1839,4323,1081,123745,114,6300,2776,91860,1432,817,6416,5894,5331,5568,3845,5606,2767,468,111,2885,6714,3708,10746,5601	GNRH2,PLA2G4F,PRKCD,ADCY2,MMP2,PLA2G4D,MAP2K6,MAPK11,ADCY4,PRKCB,ITPR3,PRKACA,PLA2G4B,ADCY3,ADCY9,ADCY7,GNAS,MAPK7,JUN,FSHB,PLCB2,PLD2,MAP3K4,CALM1,MAP3K3,PTK2B,PLCB1,HRAS,PLD1,SOS1,MAPK13,MAPK10,ADCY6,MAPK8,EGFR,SOS2,ADCY1,MAP3K1,CACNA1D,CDC42,MAP2K7,PRKCA,GNRHR,CAMK2B,PLCB4,CALML5,CACNA1S,PLA2G4C,CACNA1C,GNRH1,LHB,NRAS,ITPR2,CALM2,MAPK1,MAP2K2,CAMK2A,CAMK2G,CALM3,CALML6,PRKACB,PLA2G4A,CALML3,MAP2K1,MAPK3,HBEGF,MMP14,CGA,PLA2G4E,ADCY8,MAPK12,GNAQ,CALML4,MAPK14,CAMK2D,MAP2K4,RAF1,PLCB3,PRKACG,KRAS,MAP2K3,GNA11,ATF4,ADCY5,GRB2,SRC,ITPR1,MAP3K2,MAPK9
hsa04071	Sphingolipid signaling pathway	0.00304563819207261	-5.79404481289298	118	113	0.0179365079365079	6300	7161	5894,259230,1903,1432,2771,253782,2207,5331,10558,5525,29956,8560,1509,2776,6300,207,91012,8717,9475,5601,4790,387,140,3845,5581,5518,5293,53637,581,55304,81537,9517,7124,2768,5594,5605,56848,5519,208,10000,4893,5170,5604,5595,4217,130367,204219,6609,5526,624,596,2534,4846,5521,5290,5881,2206,5296,56624,5879,5599,8877,8503,125981,5602,5603,5528,5582,5520,5970,8439,8879,5291,5337,3265,5880,134,23236,2773,5578,1901,5332,5515,79603,340485,427,5516,10672,9846,5579,5600,5522,55012,5523,4985,7132,9294,8698,7157,6610,5590,2770,5527,123099,5330,5338,5728,4363,166929,5295,5529,2205,10715	RAF1,SGMS1,S1PR3,MAPK14,GNAI2,CERS6,FCER1G,PLCB3,SPTLC1,PPP2R5A,CERS2,DEGS1,CTSD,GNAQ,MAPK12,AKT1,CERS5,TRADD,ROCK2,MAPK9,NFKB1,RHOA,ADORA3,KRAS,PRKCE,PPP2R1A,PIK3CD,S1PR5,BAX,SPTLC3,SGPP1,SPTLC2,TNF,GNA12,MAPK1,MAP2K2,SPHK2,PPP2R1B,AKT2,AKT3,NRAS,PDPK1,MAP2K1,MAPK3,MAP3K5,SGPP2,CERS3,SMPD1,PPP2R5B,BDKRB2,BCL2,FYN,NOS3,PPP2R2B,PIK3CA,RAC3,MS4A2,PIK3R2,ASAH2,RAC1,MAPK8,SPHK1,PIK3R3,ACER1,MAPK10,MAPK13,PPP2R5D,PRKCG,PPP2R2A,RELA,NSMAF,SGPL1,PIK3CB,PLD1,HRAS,RAC2,ADORA1,PLCB1,GNAI3,PRKCA,S1PR1,PLCB4,PPP2CA,CERS4,ACER2,ASAH1,PPP2CB,GNA13,GAB2,PRKCB,MAPK11,PPP2R2C,PPP2R3C,PPP2R3A,OPRD1,TNFRSF1A,S1PR2,S1PR4,TP53,SMPD2,PRKCZ,GNAI1,PPP2R5C,DEGS2,PLCB2,PLD2,PTEN,ABCC1,SGMS2,PIK3R1,PPP2R5E,FCER1A,CERS1
ko04071	Sphingolipid signaling pathway	0.00304563819207261	-5.79404481289298	118	113	0.0179365079365079	6300	7161	5527,5590,2770,6610,7157,8698,5728,123099,5330,5338,166929,4363,10715,2205,5529,5295,5516,427,340485,5600,5579,9846,10672,4985,5523,55012,5522,9294,7132,1901,5578,2773,5332,79603,5515,5879,56624,5296,2206,5603,5602,8503,125981,5599,8877,8879,8439,5582,5528,5520,5970,134,23236,5880,3265,5291,5337,204219,130367,4217,5604,5595,624,5526,6609,5521,4846,2534,596,5881,5290,7124,9517,56848,5605,5594,2768,208,5519,5170,4893,10000,9475,91012,8717,207,387,4790,5601,3845,5581,140,55304,81537,581,53637,5293,5518,2771,1432,1903,259230,5894,5331,2207,253782,29956,10558,5525,6300,1509,2776,8560	PPP2R5C,PRKCZ,GNAI1,SMPD2,TP53,S1PR4,PTEN,DEGS2,PLCB2,PLD2,SGMS2,ABCC1,CERS1,FCER1A,PPP2R5E,PIK3R1,PPP2CB,ASAH1,ACER2,MAPK11,PRKCB,GAB2,GNA13,OPRD1,PPP2R3A,PPP2R3C,PPP2R2C,S1PR2,TNFRSF1A,S1PR1,PRKCA,GNAI3,PLCB4,CERS4,PPP2CA,RAC1,ASAH2,PIK3R2,MS4A2,MAPK13,MAPK10,PIK3R3,ACER1,MAPK8,SPHK1,SGPL1,NSMAF,PRKCG,PPP2R5D,PPP2R2A,RELA,ADORA1,PLCB1,RAC2,HRAS,PIK3CB,PLD1,CERS3,SGPP2,MAP3K5,MAP2K1,MAPK3,BDKRB2,PPP2R5B,SMPD1,PPP2R2B,NOS3,FYN,BCL2,RAC3,PIK3CA,TNF,SPTLC2,SPHK2,MAP2K2,MAPK1,GNA12,AKT2,PPP2R1B,PDPK1,NRAS,AKT3,ROCK2,CERS5,TRADD,AKT1,RHOA,NFKB1,MAPK9,KRAS,PRKCE,ADORA3,SPTLC3,SGPP1,BAX,S1PR5,PIK3CD,PPP2R1A,GNAI2,MAPK14,S1PR3,SGMS1,RAF1,PLCB3,FCER1G,CERS6,CERS2,SPTLC1,PPP2R5A,MAPK12,CTSD,GNAQ,DEGS1
ko04024	cAMP signaling pathway	0.00357817838926479	-5.63290143788165	198	186	0.0295238095238095	6300	7161	163688,7074,5348,5290,1262,2891,116444,5139,818,480,4792,55811,2033,114,5604,10000,4852,51806,483,2905,478,779,208,116443,5594,815,7409,51738,5501,2740,10257,2696,1909,4772,3352,5601,111,1816,9475,2735,482,5058,10488,5568,1387,9568,5894,113,5295,10451,10398,5908,5338,2778,2770,3725,1261,2149,6755,4886,2550,2893,4881,3362,1128,3354,108,6237,84876,6548,117,56670,268,7410,7253,816,1129,22800,4158,338442,1812,1813,134,5880,2353,54714,801,5970,6662,1080,5602,112,2693,3351,5140,476,481,4301,5499,84699,5021,5567,808,2904,5881,810,90993,5141,3350,488,5595,775,5605,84152,64764,805,5293,2906,493,387,4790,5144,8310,477,207,4659,9586,673,6262,6752,490,5906,2867,51,64411,91860,2771,817,135,153,148327,491,5566,109,115,1385,3355,5350,2488,5732,5733,1258,5500,51196,2737,814,196883,5142,5143,7434,6751,3991,486,776,627,1259,107,64399,610,2773,10021,5337,5291,5727,154,10411,2890,2903,2492,3360,8503,5599,11069,5879,5296,5465	CALML6,TIAM1,FXYD1,PIK3CA,CNGA4,GRIA2,GRIN3B,PDE3A,CAMK2G,ATP1A4,NFKBIA,ADCY10,EP300,ADCY8,MAP2K1,AKT3,NPY,CALML5,ATP1B3,GRIN2C,ATP1A3,CACNA1S,AKT2,GRIN3A,MAPK1,CAMK2A,VAV1,GHRL,PPP1CC,GLP1R,ABCC4,GIPR,EDNRA,NFATC1,HTR1D,MAPK9,ADCY5,DRD5,ROCK2,GLI1,ATP1B2,PAK1,CREB3,PRKACG,CREBBP,GABBR2,RAF1,ADCY7,PIK3R1,VAV3,MYL9,RAP1B,PLD2,GNAS,GNAI1,JUN,CNGA3,F2R,SSTR5,NPY1R,GABBR1,GRIA4,NPR1,HTR6,CHRM1,HTR1E,ADCY2,RRAS,ORAI1,SLC9A1,ADCYAP1R1,SUCNR1,AMH,VAV2,TSHR,CAMK2B,CHRM2,RRAS2,MC2R,HCAR2,DRD1,DRD2,ADORA1,RAC2,FOS,CNGB3,CALM1,RELA,SOX9,CFTR,MAPK10,ADCY6,GHSR,HTR1B,PDE3B,ATP1A1,ATP1B1,AFDN,PPP1CA,CREB3L3,OXTR,PRKACB,CALM3,GRIN2B,RAC3,CALML3,CREB3L1,PDE4A,HTR1A,ATP2A2,MAPK3,CACNA1C,MAP2K2,PPP1R1B,CREB3L2,CALM2,PIK3CD,GRIN2D,ATP2B4,RHOA,NFKB1,PDE4D,ACOX3,ATP1A2,AKT1,PPP1R12A,CREB5,BRAF,RYR2,SSTR2,ATP2B1,RAP1A,FFAR2,ACOX1,ARAP3,CALML4,GNAI2,CAMK2D,ADORA2A,ADRB1,CREB3L4,ATP2B2,PRKACA,ADCY3,ADCY9,CREB1,HTR1F,PLN,FSHB,PTGER2,PTGER3,CNGB1,PPP1CB,PLCE1,GLI3,CAMK4,ADCY4,PDE4B,PDE4C,VIPR2,SSTR1,LIPE,FXYD2,CACNA1D,BDNF,CNGA1,ADCY1,HHIP,HCN2,GNAI3,HCN4,PLD1,PIK3CB,PTCH1,ADRB2,RAPGEF3,GRIA1,GRIN2A,FSHR,HTR4,PIK3R3,MAPK8,RAPGEF4,RAC1,PIK3R2,PPARA
hsa04024	cAMP signaling pathway	0.00357817838926479	-5.63290143788165	198	186	0.0295238095238095	6300	7161	5595,488,5141,3350,90993,2904,5567,808,810,5881,64764,805,5605,84152,775,5144,9586,4659,207,8310,477,493,2906,4790,387,5293,135,817,2771,91860,153,2867,64411,51,5906,490,673,6752,6262,5350,2488,3355,109,5566,491,1385,115,148327,7434,196883,5143,5142,2737,51196,814,5733,5500,1258,5732,2773,610,1259,107,64399,6751,486,776,627,3991,5465,5296,5879,8503,3360,11069,5599,154,2903,2492,2890,10411,5337,5291,10021,5727,5604,480,114,2033,55811,4792,5139,818,116444,2891,5348,7074,163688,1262,5290,5594,815,51806,4852,208,116443,779,483,478,2905,10000,111,482,2735,9475,1816,1909,5601,3352,4772,2740,2696,10257,51738,7409,5501,9568,1387,5894,5568,10488,5058,3725,2778,2770,5908,5338,10398,10451,113,5295,6237,108,3354,1128,84876,4881,3362,4886,2893,2550,1261,2149,6755,4158,338442,22800,816,1129,268,56670,7253,7410,117,6548,4301,5499,5021,84699,3351,112,2693,5602,1080,481,476,5140,801,54714,6662,5970,1813,5880,134,1812,2353	MAPK3,ATP2A2,PDE4A,HTR1A,CREB3L1,GRIN2B,PRKACB,CALM3,CALML3,RAC3,CREB3L2,CALM2,MAP2K2,PPP1R1B,CACNA1C,PDE4D,CREB5,PPP1R12A,AKT1,ACOX3,ATP1A2,ATP2B4,GRIN2D,NFKB1,RHOA,PIK3CD,ADORA2A,CAMK2D,GNAI2,CALML4,ADRB1,FFAR2,ARAP3,ACOX1,RAP1A,ATP2B1,BRAF,SSTR2,RYR2,PLN,FSHB,HTR1F,ADCY3,PRKACA,ATP2B2,CREB1,ADCY9,CREB3L4,VIPR2,ADCY4,PDE4C,PDE4B,GLI3,PLCE1,CAMK4,PTGER3,PPP1CB,CNGB1,PTGER2,GNAI3,HCN2,CNGA1,ADCY1,HHIP,SSTR1,FXYD2,CACNA1D,BDNF,LIPE,PPARA,PIK3R2,RAC1,PIK3R3,HTR4,RAPGEF4,MAPK8,ADRB2,GRIN2A,FSHR,GRIA1,RAPGEF3,PLD1,PIK3CB,HCN4,PTCH1,MAP2K1,ATP1A4,ADCY8,EP300,ADCY10,NFKBIA,PDE3A,CAMK2G,GRIN3B,GRIA2,FXYD1,TIAM1,CALML6,CNGA4,PIK3CA,MAPK1,CAMK2A,CALML5,NPY,AKT2,GRIN3A,CACNA1S,ATP1B3,ATP1A3,GRIN2C,AKT3,ADCY5,ATP1B2,GLI1,ROCK2,DRD5,EDNRA,MAPK9,HTR1D,NFATC1,GLP1R,GIPR,ABCC4,GHRL,VAV1,PPP1CC,GABBR2,CREBBP,RAF1,PRKACG,CREB3,PAK1,JUN,GNAS,GNAI1,RAP1B,PLD2,MYL9,VAV3,ADCY7,PIK3R1,RRAS,ADCY2,HTR1E,CHRM1,ORAI1,NPR1,HTR6,NPY1R,GRIA4,GABBR1,CNGA3,F2R,SSTR5,MC2R,HCAR2,RRAS2,CAMK2B,CHRM2,AMH,SUCNR1,TSHR,VAV2,ADCYAP1R1,SLC9A1,AFDN,PPP1CA,OXTR,CREB3L3,HTR1B,ADCY6,GHSR,MAPK10,CFTR,ATP1B1,ATP1A1,PDE3B,CALM1,CNGB3,SOX9,RELA,DRD2,RAC2,ADORA1,DRD1,FOS
ko04666	Fc gamma R-mediated phagocytosis	0.00366280456220819	-5.60952615117938	90	87	0.0138095238095238	6300	7161	10092,5894,653361,10095,2209,5336,5058,382,207,2214,5581,10094,5293,7409,8936,4067,1398,2934,81873,56848,5594,208,8394,7408,50807,10000,5604,5595,5335,6850,123745,85477,8613,8395,8612,5290,274,8976,5321,3636,1785,5296,5879,8877,8503,5582,55616,10163,1794,10109,5880,5337,5291,5578,998,5788,4651,7410,10810,6199,1073,1072,3984,283748,23396,9846,5579,5580,255189,4082,65108,6198,10552,8611,2213,2212,5338,27040,273,10093,3985,8853,10451,100137049,5295,8398,3635	ARPC5,RAF1,NCF1,ARPC1B,FCGR1A,PLCG2,PAK1,ARF6,AKT1,FCGR3A,PRKCE,ARPC3,PIK3CD,VAV1,WASF1,LYN,CRK,GSN,ARPC5L,SPHK2,MAPK1,AKT2,PIP5K1A,VASP,ASAP1,AKT3,MAP2K1,MAPK3,PLCG1,SYK,PLA2G4E,SCIN,PLPP3,PIP5K1B,PLPP2,PIK3CA,BIN1,WASL,PLA2G4A,INPPL1,DNM2,PIK3R2,RAC1,SPHK1,PIK3R3,PRKCG,ASAP3,WASF2,DOCK2,ARPC2,RAC2,PLD1,PIK3CB,PRKCA,CDC42,PTPRC,MYO10,VAV2,WASF3,RPS6KB2,CFL2,CFL1,LIMK1,PLA2G4D,PIP5K1C,GAB2,PRKCB,PRKCD,PLA2G4F,MARCKS,MARCKSL1,RPS6KB1,ARPC1A,PLPP1,FCGR2B,FCGR2A,PLD2,LAT,AMPH,ARPC4,LIMK2,ASAP2,VAV3,PLA2G4B,PIK3R1,PLA2G6,INPP5D
hsa04666	Fc gamma R-mediated phagocytosis	0.00366280456220819	-5.60952615117938	90	87	0.0138095238095238	6300	7161	55616,5582,5291,5337,5880,10109,1794,10163,5296,1785,5879,3636,8503,8877,10810,7410,1073,1072,6199,998,5578,4651,5788,6198,65108,255189,5580,4082,2213,2212,8611,10552,23396,3984,283748,9846,5579,100137049,10451,8853,3635,5295,8398,3985,273,10093,5338,27040,5336,2209,382,5058,5894,10092,10095,653361,10094,5581,2214,8936,4067,7409,5293,207,8394,7408,208,50807,10000,1398,2934,5594,56848,81873,5321,8976,274,8395,8613,8612,5290,5595,5604,85477,123745,6850,5335	ASAP3,PRKCG,PIK3CB,PLD1,RAC2,ARPC2,DOCK2,WASF2,PIK3R2,DNM2,RAC1,INPPL1,PIK3R3,SPHK1,WASF3,VAV2,CFL2,CFL1,RPS6KB2,CDC42,PRKCA,MYO10,PTPRC,RPS6KB1,MARCKSL1,PLA2G4F,PRKCD,MARCKS,FCGR2B,FCGR2A,PLPP1,ARPC1A,PIP5K1C,LIMK1,PLA2G4D,GAB2,PRKCB,PLA2G4B,VAV3,ASAP2,INPP5D,PIK3R1,PLA2G6,LIMK2,AMPH,ARPC4,PLD2,LAT,PLCG2,FCGR1A,ARF6,PAK1,RAF1,ARPC5,ARPC1B,NCF1,ARPC3,PRKCE,FCGR3A,WASF1,LYN,VAV1,PIK3CD,AKT1,PIP5K1A,VASP,AKT2,ASAP1,AKT3,CRK,GSN,MAPK1,SPHK2,ARPC5L,PLA2G4A,WASL,BIN1,PIP5K1B,PLPP3,PLPP2,PIK3CA,MAPK3,MAP2K1,SCIN,PLA2G4E,SYK,PLCG1
ko04360	Axon guidance	0.00401085006031072	-5.51875207501444	174	164	0.026031746031746	6300	7161	3983,27289,387,4773,22854,2050,80031,151449,9475,6714,2045,5293,57522,90249,1808,6091,10154,57144,3845,29984,23380,7225,9901,6608,2771,817,5894,5058,84612,5336,2044,1946,655,9037,56924,8440,5335,10500,57556,56920,6387,7852,5535,659,5595,23654,5747,5881,91653,5290,84628,818,2534,54961,10509,54361,5534,3688,5594,64221,5781,815,5921,54437,85464,4690,2046,5362,3611,1944,4893,1630,10505,658,5364,2932,816,1942,1943,7869,59277,285220,25791,9353,998,8829,6469,8633,9723,5578,56288,2773,5532,64101,5533,5062,10512,1072,1073,2048,5163,81029,8482,7220,8503,4233,137970,57689,1949,5879,7474,10298,5296,6092,5880,3265,5291,5727,6405,84552,6585,4776,10371,22885,64218,2242,1948,3985,10501,4775,7976,6586,54434,84448,5361,219699,2770,5590,5530,2042,2043,1969,5295,7223,7222,10507,1020,23365,2047,4917,25,6237,2051,91584,3984,57715,223117,6259,2049,55740,9423,54910,56896,5998	ABLIM1,RND1,RHOA,NFATC2,NTNG1,EPHB4,SEMA6D,GDF7,ROCK2,SRC,EPHA7,PIK3CD,SRGAP1,UNC5A,DPYSL2,ROBO1,PLXNC1,PAK5,KRAS,RHOD,SRGAP2,TRPC6,SRGAP3,SMO,GNAI2,CAMK2D,RAF1,PAK1,PARD6B,PLCG2,EPHA5,EFNA5,BMP7,SEMA5A,PAK6,NCK2,PLCG1,SEMA6C,SEMA6A,SEMA3G,CXCL12,CXCR4,PPP3R2,BMPR2,MAPK3,PLXNB2,PTK2,RAC3,BOC,PIK3CA,NTNG2,CAMK2G,FYN,SSH3,SEMA4B,WNT4,PPP3R1,ITGB1,MAPK1,ROBO3,PTPN11,CAMK2A,RASA1,SEMA5B,SSH2,NCK1,EPHA8,PLXNA2,ILK,EFNA3,NRAS,DCC,SEMA4F,BMPR1B,PLXNB1,GSK3B,CAMK2B,EFNA1,EFNA2,SEMA3B,NTN4,EPHA6,NGEF,SLIT2,CDC42,NRP1,SHH,UNC5C,SEMA3E,PRKCA,PARD3,GNAI3,PPP3CB,LRRC4,PPP3CC,PAK2,SEMA3C,CFL1,CFL2,EPHB2,PDK1,WNT5B,SEMA7A,TRPC1,PIK3R3,MET,UNC5D,LRRC4C,EFNB3,RAC1,WNT5A,PAK4,PIK3R2,ROBO2,RAC2,HRAS,PIK3CB,PTCH1,SEMA3F,PARD6G,SLIT1,NFATC4,SEMA3A,ABLIM3,SEMA4A,FES,EFNB2,LIMK2,SEMA6B,NFATC3,FZD3,SLIT3,SSH1,ABLIM2,PLXNA1,UNC5B,GNAI1,PRKCZ,PPP3CA,EPHA3,EPHA4,EPHA2,PIK3R1,TRPC4,TRPC3,SEMA4D,CDK5,ARHGEF12,EPHB1,NTN3,ABL1,RRAS,EPHB6,PLXNA4,LIMK1,SEMA4G,SEMA3D,RYK,EPHB3,ENAH,NTN1,SEMA4C,DPYSL5,RGS3
hsa04360	Axon guidance	0.00401085006031072	-5.51875207501444	174	164	0.026031746031746	6300	7161	2045,5293,57522,90249,6091,10154,1808,3845,57144,29984,3983,27289,387,4773,22854,2050,80031,151449,9475,6714,5058,84612,5336,2044,1946,23380,7225,9901,6608,2771,817,5894,5747,5881,91653,5290,84628,818,2534,655,9037,56924,5335,8440,57556,10500,56920,6387,7852,5535,5595,659,23654,4893,1630,10505,658,10509,54961,54361,3688,5534,5594,5781,64221,815,5921,54437,85464,4690,5362,2046,3611,1944,5062,1072,10512,2048,1073,5163,2932,816,5364,1942,1943,7869,59277,285220,25791,9353,998,6469,8829,8633,56288,5578,9723,2773,5532,64101,5533,6092,5880,3265,5291,5727,6405,84552,6585,4776,10371,64218,22885,2242,81029,8482,7220,8503,4233,137970,57689,5879,1949,5296,7474,10298,2042,2043,1969,5295,3985,1948,10501,4775,7976,6586,84448,54434,5361,219699,2770,5590,5530,57715,223117,6259,2049,55740,9423,56896,54910,5998,7223,7222,10507,1020,23365,4917,2047,25,6237,2051,91584,3984	EPHA7,PIK3CD,SRGAP1,UNC5A,ROBO1,PLXNC1,DPYSL2,KRAS,PAK5,RHOD,ABLIM1,RND1,RHOA,NFATC2,NTNG1,EPHB4,SEMA6D,GDF7,ROCK2,SRC,PAK1,PARD6B,PLCG2,EPHA5,EFNA5,SRGAP2,TRPC6,SRGAP3,SMO,GNAI2,CAMK2D,RAF1,PTK2,RAC3,BOC,PIK3CA,NTNG2,CAMK2G,FYN,BMP7,SEMA5A,PAK6,PLCG1,NCK2,SEMA6A,SEMA6C,SEMA3G,CXCL12,CXCR4,PPP3R2,MAPK3,BMPR2,PLXNB2,NRAS,DCC,SEMA4F,BMPR1B,SEMA4B,SSH3,WNT4,ITGB1,PPP3R1,MAPK1,PTPN11,ROBO3,CAMK2A,RASA1,SEMA5B,SSH2,NCK1,PLXNA2,EPHA8,ILK,EFNA3,PAK2,CFL1,SEMA3C,EPHB2,CFL2,PDK1,GSK3B,CAMK2B,PLXNB1,EFNA1,EFNA2,SEMA3B,NTN4,EPHA6,NGEF,SLIT2,CDC42,SHH,NRP1,UNC5C,PARD3,PRKCA,SEMA3E,GNAI3,PPP3CB,LRRC4,PPP3CC,ROBO2,RAC2,HRAS,PIK3CB,PTCH1,SEMA3F,PARD6G,SLIT1,NFATC4,SEMA3A,SEMA4A,ABLIM3,FES,WNT5B,SEMA7A,TRPC1,PIK3R3,MET,UNC5D,LRRC4C,RAC1,EFNB3,PIK3R2,WNT5A,PAK4,EPHA3,EPHA4,EPHA2,PIK3R1,LIMK2,EFNB2,SEMA6B,NFATC3,FZD3,SLIT3,ABLIM2,SSH1,PLXNA1,UNC5B,GNAI1,PRKCZ,PPP3CA,SEMA4G,SEMA3D,RYK,EPHB3,ENAH,NTN1,DPYSL5,SEMA4C,RGS3,TRPC4,TRPC3,SEMA4D,CDK5,ARHGEF12,NTN3,EPHB1,ABL1,RRAS,EPHB6,PLXNA4,LIMK1
hsa04211	Longevity regulating pathway	0.00404184212640821	-5.51105471904945	89	86	0.0136507936507937	6300	7161	143686,1388,90993,3630,5567,5290,7248,114,79602,3480,208,10000,84335,4893,5571,64764,60673,1977,3479,5562,5563,9821,3845,468,581,1978,5293,111,207,9586,51422,9776,4790,2475,10645,5468,7249,9474,5568,8660,10488,109,5566,847,115,1385,148327,113,5295,23411,6794,7157,3667,2308,6198,26060,814,108,8408,196883,107,6199,10891,9370,5564,10919,27244,9470,6648,53632,3643,51094,5970,83667,3265,5291,5296,2309,84699,112,1386,9365,8503,57521,5565,6009	SESN3,ATF6B,CREB3L1,INS,PRKACB,PIK3CA,TSC1,ADCY8,ADIPOR2,IGF1R,AKT2,AKT3,AKT1S1,NRAS,PRKAG1,CREB3L2,ATG101,EIF4E,IGF1,PRKAA1,PRKAA2,RB1CC1,KRAS,ATF4,BAX,EIF4EBP1,PIK3CD,ADCY5,AKT1,CREB5,PRKAG2,ATG13,NFKB1,MTOR,CAMKK2,PPARG,TSC2,ATG5,PRKACG,IRS2,CREB3,ADCY3,PRKACA,CAT,ADCY9,CREB1,CREB3L4,ADCY7,PIK3R1,SIRT1,STK11,TP53,IRS1,FOXO1,RPS6KB1,APPL1,CAMK4,ADCY2,ULK1,ADCY4,ADCY1,RPS6KB2,PPARGC1A,ADIPOQ,PRKAB1,EHMT2,SESN1,EIF4E2,SOD2,PRKAG3,INSR,ADIPOR1,RELA,SESN2,HRAS,PIK3CB,PIK3R2,FOXO3,CREB3L3,ADCY6,ATF2,KL,PIK3R3,RPTOR,PRKAB2,RHEB
hsa04540	Gap junction	0.0044586076794417	-5.4129187411857	88	85	0.0134920634920635	6300	7161	10381,5604,7082,5595,5598,2770,2778,114,983,5330,5156,115,109,1950,5566,5159,5567,113,7846,108,79861,3709,7277,5579,3710,196883,5605,5594,7280,51807,56034,2911,10382,2977,4893,6714,5592,2773,5593,2885,5578,111,10746,5332,347733,203068,3708,10376,107,6655,112714,2915,3845,2697,80310,5607,5154,7278,2767,5894,153,1902,347688,2771,5568,1453,1956,84617,81027,112,84790,5331,5155,5582,3356,6654,2776,57369,3265,23236,2983,1813,3357,1812,2982	TUBB3,MAP2K1,TJP1,MAPK3,MAPK7,GNAI1,GNAS,ADCY8,CDK1,PLCB2,PDGFRA,ADCY9,ADCY3,EGF,PRKACA,PDGFRB,PRKACB,ADCY7,TUBA1A,ADCY2,TUBAL3,ITPR2,TUBA4A,PRKCB,ITPR3,ADCY4,MAP2K2,MAPK1,TUBB2A,TUBA8,PDGFC,GRM1,TUBB4A,GUCY1A2,NRAS,SRC,PRKG1,GNAI3,PRKG2,GRB2,PRKCA,ADCY5,MAP3K2,PLCB4,TUBB2B,TUBB,ITPR1,TUBA1B,ADCY1,SOS2,TUBA3E,GRM5,KRAS,GJA1,PDGFD,MAP2K5,PDGFA,TUBA3C,GNA11,RAF1,ADRB1,LPAR1,TUBB8,GNAI2,PRKACG,CSNK1D,EGFR,TUBB6,TUBB1,ADCY6,TUBA1C,PLCB3,PDGFB,PRKCG,HTR2A,SOS1,GNAQ,GJD2,HRAS,PLCB1,GUCY1B1,DRD2,HTR2B,DRD1,GUCY1A1
ko04540	Gap junction	0.0044586076794417	-5.4129187411857	88	85	0.0134920634920635	6300	7161	2767,7278,5154,80310,2697,5607,112714,6655,107,3845,2915,10376,3708,5332,10746,203068,347733,111,5593,2773,5592,6714,2885,5578,3265,57369,2776,3357,2982,1812,1813,23236,2983,6654,3356,5582,5155,84790,81027,112,84617,5331,1453,5568,1956,347688,1902,2771,5894,153,113,5567,5159,1950,109,5566,115,5156,114,983,5330,10381,2770,5598,2778,7082,5595,5604,4893,2977,10382,2911,56034,51807,5605,196883,5594,7280,7277,5579,3710,108,3709,79861,7846	GNA11,TUBA3C,PDGFA,PDGFD,GJA1,MAP2K5,TUBA3E,SOS2,ADCY1,KRAS,GRM5,TUBA1B,ITPR1,PLCB4,MAP3K2,TUBB,TUBB2B,ADCY5,PRKG2,GNAI3,PRKG1,SRC,GRB2,PRKCA,HRAS,GJD2,GNAQ,HTR2B,GUCY1A1,DRD1,DRD2,PLCB1,GUCY1B1,SOS1,HTR2A,PRKCG,PDGFB,TUBA1C,TUBB1,ADCY6,TUBB6,PLCB3,CSNK1D,PRKACG,EGFR,TUBB8,LPAR1,GNAI2,RAF1,ADRB1,ADCY7,PRKACB,PDGFRB,EGF,ADCY3,PRKACA,ADCY9,PDGFRA,ADCY8,CDK1,PLCB2,TUBB3,GNAI1,MAPK7,GNAS,TJP1,MAPK3,MAP2K1,NRAS,GUCY1A2,TUBB4A,GRM1,PDGFC,TUBA8,MAP2K2,ADCY4,MAPK1,TUBB2A,TUBA4A,PRKCB,ITPR3,ADCY2,ITPR2,TUBAL3,TUBA1A
hsa04014	Ras signaling pathway	0.00494281157823609	-5.3098209642922	226	211	0.0334920634920635	6300	7161	2885,11145,5601,5869,26279,57144,94235,80310,2784,2257,2264,5894,51365,399694,5568,5228,2252,29110,2253,6789,5058,5604,123745,5335,2786,5290,51764,7074,163688,5868,25780,51378,3479,9462,5781,2261,5594,208,51806,22808,10000,5319,8605,2790,391013,3643,2251,22800,2256,2249,5154,4301,10298,8437,26291,1956,4233,5602,5970,30814,801,5320,6654,59345,83593,10156,5880,26281,2787,2254,27040,5338,2263,5900,5908,5156,54331,5295,50487,283748,6237,5966,1435,84647,25,9846,356,3363,2783,2782,2248,255189,285,207,2259,2549,9610,4790,387,2246,3845,9771,5293,91860,115727,5863,2324,10681,55770,5924,8817,1946,5906,5336,11186,64600,382,64926,6464,5595,4803,10235,56924,4254,1950,5159,5881,810,3815,2904,3630,5321,808,5567,2321,1944,805,5921,2791,53358,2250,7010,5605,55970,284,3480,56034,2114,1147,7422,8831,7423,4893,8315,5578,2247,998,598,1942,100271927,1943,5898,2260,7424,6655,27,9965,1436,2113,5062,4763,3551,5879,5296,23179,81579,4804,5599,8503,8822,5582,5155,2903,2788,3265,5291,5337,5922,2792,2793,5923,25759,7535,27006,8074,3082,5878,100137049,3791,5566,8398,1969,8036,10125,5899,2255,283455,5579,51196,5322,10928	GRB2,PLAAT3,MAPK9,RAB5B,PLA2G2D,PAK5,GNG8,PDGFD,GNB3,FGF12,FGFR4,RAF1,PLA1A,SHC4,PRKACG,PGF,FGF7,TBK1,FGF8,STK4,PAK1,MAP2K1,PLA2G4E,PLCG1,GNG4,PIK3CA,GNG13,TIAM1,CALML6,RAB5A,RASGRP3,ANGPT4,IGF1,RASAL2,PTPN11,FGFR3,MAPK1,AKT2,CALML5,MRAS,AKT3,PLA2G1B,PLA2G4C,GNG10,PLA2G2C,INSR,FGF6,RRAS2,FGF11,FGF4,PDGFA,AFDN,PAK4,RASAL1,FGF21,EGFR,MET,MAPK10,RELA,PLA2G2E,CALM1,PLA2G2A,SOS1,GNB4,RASSF5,RASA4,RAC2,FGF20,GNG5,FGF9,LAT,PLD2,FGFR2,RALGDS,RAP1B,PDGFRA,GNG2,PIK3R1,PLA2G3,PLA2G4D,RRAS,REL,CSF1,PLA2G12B,ABL1,GAB2,FASLG,HTR7,GNB2,GNB1,FGF3,PLA2G4F,ANGPT2,AKT1,FGF14,GAB1,RIN1,NFKB1,RHOA,FGF1,KRAS,RAPGEF5,PIK3CD,CALML4,RASGRP4,RGL2,FLT4,GNB5,EXOC2,RASGRF2,FGF18,EFNA5,RAP1A,PLCG2,RASSF1,PLA2G2F,ARF6,RASAL3,SHC1,MAPK3,NGF,RASGRP2,PAK6,KITLG,EGF,PDGFRB,RAC3,CALML3,KIT,GRIN2B,INS,PLA2G4A,CALM3,PRKACB,FLT1,EFNA3,CALM2,RASA1,GNG11,SHC3,FGF5,TEK,MAP2K2,GNG12,ANGPT1,IGF1R,PDGFC,ETS2,CHUK,VEGFA,SYNGAP1,VEGFB,NRAS,BRAP,PRKCA,FGF2,CDC42,BCL2L1,EFNA1,RASA4B,EFNA2,RALA,FGFR1,VEGFC,SOS2,ABL2,FGF19,CSF1R,ETS1,PAK2,NF1,IKBKB,RAC1,PIK3R2,RGL1,PLA2G12A,NGFR,MAPK8,PIK3R3,FGF17,PRKCG,PDGFB,GRIN2A,GNG7,HRAS,PIK3CB,PLD1,RASA2,GNGT1,GNGT2,RASGRF1,SHC2,ZAP70,FGF22,FGF23,HGF,RAB5C,PLA2G4B,KDR,PRKACA,PLA2G6,EPHA2,SHOC2,RASGRP1,RALB,FGF10,KSR2,PRKCB,PLCE1,PLA2G5,RALBP1
ko04062	Chemokine signaling pathway	0.0050774594339071	-5.28294425392479	182	171	0.0271428571428571	6300	7161	1236,6361,6358,387,4790,111,6373,2885,729230,9475,6372,6714,207,7409,2784,4067,5293,3845,94235,6366,5331,10681,5568,2931,653361,399694,2771,5894,673,2826,5058,2869,5906,6352,643,2786,3702,56477,4792,5197,10235,4793,114,6387,7852,6364,5595,5604,6777,6464,6370,1234,7074,5747,5567,51764,8976,2921,3627,2868,5290,55970,10563,5594,57580,6346,53358,2791,3579,1398,58191,157,2919,3577,4893,6357,10000,6773,6772,1147,1235,208,2268,2932,6355,9564,388372,10663,5332,1237,998,2790,56288,6369,2773,6367,3717,6774,6348,5829,6655,107,7410,10803,8503,112,6363,2829,6362,5296,5879,3551,6354,2309,23236,5880,2920,6376,5291,3265,9844,59345,6654,1794,1524,1232,1233,2788,2185,5970,5908,156,5330,409,2787,5196,25759,5590,2770,6011,2793,2792,113,131890,5295,10451,5566,109,54331,115,6374,196883,10344,6360,6368,3718,5579,6351,108,414062,6347,6349,408,10850,5580,6356,2870,3576,2782,2783,1230	CCR7,CCL17,CCL14,RHOA,NFKB1,ADCY5,CXCL11,GRB2,CCR2,ROCK2,CXCL6,SRC,AKT1,VAV1,GNB3,LYN,PIK3CD,KRAS,GNG8,CCL21,PLCB3,GNB5,PRKACG,GSK3A,NCF1,SHC4,GNAI2,RAF1,BRAF,CCR10,PAK1,GRK5,RAP1A,CCL5,CXCR5,GNG4,ITK,CCL28,NFKBIA,PF4V1,RASGRP2,NFKBIB,ADCY8,CXCL12,CXCR4,CCL20,MAPK3,MAP2K1,STAT5B,SHC1,CCL25,CCR5,TIAM1,PTK2,PRKACB,GNG13,WASL,CXCL3,CXCL10,GRK4,PIK3CA,GNG12,CXCL13,MAPK1,PREX1,CCL1,SHC3,GNG11,CXCR2,CRK,CXCL16,GRK3,CXCL1,CXCR1,NRAS,CCL13,AKT3,STAT2,STAT1,CHUK,CCR6,AKT2,FGR,GSK3B,CCL8,BCAR1,CCL4L1,CXCR6,PLCB4,CCR8,CDC42,GNG10,PARD3,CCL24,GNAI3,CCL22,JAK2,STAT3,CCL3,PXN,SOS2,ADCY1,VAV2,CCR9,PIK3R3,ADCY6,CCL19,XCR1,CCL18,PIK3R2,RAC1,IKBKB,CCL7,FOXO3,PLCB1,RAC2,CXCL2,CX3CL1,PIK3CB,HRAS,ELMO1,GNB4,SOS1,DOCK2,CX3CR1,CCR3,CCR4,GNG7,PTK2B,RELA,RAP1B,GRK2,PLCB2,ARRB2,GNG5,PF4,SHC2,PRKCZ,GNAI1,GRK1,GNGT2,GNGT1,ADCY7,GRK7,PIK3R1,VAV3,PRKACA,ADCY3,GNG2,ADCY9,CXCL5,ADCY4,CCL26,CCL16,CCL23,JAK3,PRKCB,CCL4,ADCY2,CCL3L3,CCL2,CCL3L1,ARRB1,CCL27,PRKCD,CCL11,GRK6,CXCL8,GNB1,GNB2,CCR1
hsa04062	Chemokine signaling pathway	0.0050774594339071	-5.28294425392479	182	171	0.0271428571428571	6300	7161	9844,59345,6654,1794,5880,23236,6376,2920,5291,3265,1232,1233,2788,2185,5970,1524,6363,2829,6362,10803,8503,112,6354,2309,5296,5879,3551,6774,6367,3717,7410,6348,5829,6655,107,9564,388372,10663,5332,2268,2932,6355,2790,56288,6369,2773,998,1237,408,6349,5580,6356,3576,2870,2782,1230,2783,10850,6360,6368,3718,5579,6351,6374,196883,10344,414062,6347,108,131890,5295,113,54331,115,5566,10451,109,5330,156,409,5908,5196,25759,5590,2770,6011,2793,2792,2787,5058,673,2826,5906,2869,10681,5568,653361,2931,5331,5894,399694,2771,5293,7409,2784,4067,3845,94235,6366,387,4790,1236,6361,6358,6373,2885,9475,6372,729230,6714,207,111,3577,4893,6357,10000,2919,1235,208,6773,6772,1147,57580,53358,6346,5594,10563,55970,1398,58191,157,2791,3579,2921,3627,5290,2868,51764,7074,1234,5747,5567,8976,4792,5197,10235,4793,114,643,6352,2786,3702,56477,5604,5595,6777,6464,6370,7852,6387,6364	ELMO1,GNB4,SOS1,DOCK2,RAC2,PLCB1,CX3CL1,CXCL2,PIK3CB,HRAS,CCR3,CCR4,GNG7,PTK2B,RELA,CX3CR1,CCL19,XCR1,CCL18,CCR9,PIK3R3,ADCY6,CCL7,FOXO3,PIK3R2,RAC1,IKBKB,STAT3,CCL22,JAK2,VAV2,CCL3,PXN,SOS2,ADCY1,BCAR1,CCL4L1,CXCR6,PLCB4,FGR,GSK3B,CCL8,GNG10,PARD3,CCL24,GNAI3,CDC42,CCR8,ARRB1,CCL3L1,PRKCD,CCL11,CXCL8,GRK6,GNB1,CCR1,GNB2,CCL27,CCL16,CCL23,JAK3,PRKCB,CCL4,CXCL5,ADCY4,CCL26,CCL3L3,CCL2,ADCY2,GRK7,PIK3R1,ADCY7,GNG2,ADCY9,PRKACA,VAV3,ADCY3,PLCB2,GRK2,ARRB2,RAP1B,PF4,SHC2,PRKCZ,GNAI1,GRK1,GNGT2,GNGT1,GNG5,PAK1,BRAF,CCR10,RAP1A,GRK5,GNB5,PRKACG,NCF1,GSK3A,PLCB3,RAF1,SHC4,GNAI2,PIK3CD,VAV1,GNB3,LYN,KRAS,GNG8,CCL21,RHOA,NFKB1,CCR7,CCL17,CCL14,CXCL11,GRB2,ROCK2,CXCL6,CCR2,SRC,AKT1,ADCY5,CXCR1,NRAS,CCL13,AKT3,CXCL1,CCR6,AKT2,STAT2,STAT1,CHUK,PREX1,SHC3,CCL1,MAPK1,CXCL13,GNG12,CRK,CXCL16,GRK3,GNG11,CXCR2,CXCL3,CXCL10,PIK3CA,GRK4,GNG13,TIAM1,CCR5,PTK2,PRKACB,WASL,NFKBIA,PF4V1,RASGRP2,NFKBIB,ADCY8,CXCR5,CCL5,GNG4,ITK,CCL28,MAP2K1,MAPK3,STAT5B,SHC1,CCL25,CXCR4,CXCL12,CCL20
hsa04725	Cholinergic synapse	0.00518813244629576	-5.26138148349842	112	107	0.016984126984127	6300	7161	2787,2793,2792,2770,56479,5330,109,1132,1133,5566,1385,54331,115,148327,113,5295,3768,3760,108,1128,1141,8973,1137,196883,1103,3710,5579,5294,146850,2782,2783,814,1139,3786,60482,2773,3785,5578,2790,1129,816,5332,107,3717,3763,776,5296,84699,8503,112,3784,5582,2788,5291,3265,23236,23533,2353,59345,1143,5595,5604,2786,114,3759,818,596,2534,90993,51764,5567,5290,64764,2791,3709,5594,55970,815,1136,43,3770,1131,208,9132,779,773,775,10000,4893,111,9586,207,3708,94235,3845,2784,468,2767,5293,817,2771,5331,5568,10681,10488,2776,3761	GNG5,GNGT2,GNGT1,GNAI1,KCNQ5,PLCB2,ADCY3,CHRM4,CHRM5,PRKACA,CREB1,GNG2,ADCY9,CREB3L4,ADCY7,PIK3R1,KCNJ12,KCNJ3,ADCY2,CHRM1,CHRNB2,CHRNA6,CHRNA4,ADCY4,CHAT,ITPR3,PRKCB,PIK3CG,PIK3R6,GNB1,GNB2,CAMK4,CHRNA7,KCNQ3,SLC5A7,GNAI3,KCNQ2,PRKCA,GNG10,CHRM2,CAMK2B,PLCB4,ADCY1,JAK2,KCNJ6,CACNA1D,PIK3R2,CREB3L3,PIK3R3,ADCY6,KCNQ1,PRKCG,GNG7,PIK3CB,HRAS,PLCB1,PIK3R5,FOS,GNB4,CHRNB4,MAPK3,MAP2K1,GNG4,ADCY8,KCNJ2,CAMK2G,BCL2,FYN,CREB3L1,GNG13,PRKACB,PIK3CA,CREB3L2,GNG11,ITPR2,MAPK1,GNG12,CAMK2A,CHRNA3,ACHE,KCNJ14,CHRM3,AKT2,KCNQ4,CACNA1S,CACNA1A,CACNA1C,AKT3,NRAS,ADCY5,CREB5,AKT1,ITPR1,GNG8,KRAS,GNB3,ATF4,GNA11,PIK3CD,CAMK2D,GNAI2,PLCB3,PRKACG,GNB5,CREB3,GNAQ,KCNJ4
hsa04611	Platelet activation	0.00572753272204344	-5.16247043050699	123	117	0.0185714285714286	6300	7161	2266,208,7408,10000,8605,91807,6915,4638,3709,5742,5594,3688,2534,4846,85366,5290,2244,3690,5321,5584,5567,3673,5595,7450,5028,114,123745,6850,10627,10235,5906,9138,5336,103910,51206,2776,6300,1281,1432,2771,5568,2207,5331,83660,5501,5293,4067,6916,6714,4659,207,9475,111,54518,5023,3937,387,3708,255189,5294,146850,2977,5500,2212,2149,83706,283748,10125,84876,108,2815,10672,60,3710,23365,196883,5600,64805,115,109,100137049,5739,5566,5295,113,5590,8673,2778,2770,1277,2814,5330,5908,1278,2243,3674,23533,6786,5291,2983,23236,2982,5296,5499,8503,71,112,8773,5603,107,340156,2909,5592,2773,5593,5332,2811	FGG,AKT2,VASP,AKT3,PLA2G4C,MYLK3,TBXA2R,MYLK,ITPR2,PTGS1,MAPK1,ITGB1,FYN,NOS3,MYLK2,PIK3CA,FGB,ITGB3,PLA2G4A,PRKCI,PRKACB,ITGA2,MAPK3,VWF,P2RY1,ADCY8,PLA2G4E,SYK,MYL12A,RASGRP2,RAP1A,ARHGEF1,PLCG2,MYL12B,GP6,GNAQ,MAPK12,COL3A1,MAPK14,GNAI2,PRKACG,FCER1G,PLCB3,TLN2,PPP1CC,PIK3CD,LYN,TBXAS1,SRC,PPP1R12A,AKT1,ROCK2,ADCY5,APBB1IP,P2RX1,LCP2,RHOA,ITPR1,PLA2G4F,PIK3CG,PIK3R6,GUCY1A2,PPP1CB,FCGR2A,F2R,FERMT3,PLA2G4D,RASGRP1,ORAI1,ADCY2,GP9,GNA13,ACTB,ITPR3,ARHGEF12,ADCY4,MAPK11,P2RY12,ADCY9,ADCY3,PLA2G4B,PTGIR,PRKACA,PIK3R1,ADCY7,PRKCZ,VAMP8,GNAS,GNAI1,COL1A1,GP5,PLCB2,RAP1B,COL1A2,FGA,ITGA2B,PIK3R5,STIM1,PIK3CB,GUCY1B1,PLCB1,GUCY1A1,PIK3R2,PPP1CA,PIK3R3,ACTG1,ADCY6,SNAP23,MAPK13,ADCY1,MYLK4,ARHGAP35,PRKG1,GNAI3,PRKG2,PLCB4,GP1BA
ko04976	Bile secretion	0.00622764938355165	-5.07875632339157	71	69	0.010952380952381	6300	7161	760,8647,6579,57835,481,5568,476,6554,112,1080,358,6580,8431,6522,6523,6344,1581,3949,64240,482,477,6555,338821,6550,111,10599,64241,949,343,10864,5243,123264,6513,10257,107,486,6548,6256,5244,8671,7363,108,3781,196883,483,478,6822,9376,366,3156,2778,2052,200931,114,1244,570,480,361,115,1576,109,5566,9429,8714,9971,57552,5567,113,28234	CA2,ABCB11,SLCO1A2,SLC4A5,ATP1B1,PRKACG,ATP1A1,SLC10A1,ADCY6,CFTR,AQP1,SLC22A1,NR0B2,SLC4A2,SLC5A1,SCTR,CYP7A1,LDLR,ABCG5,ATP1B2,ATP1A2,SLC10A2,SLCO1B7,SLC9A3,ADCY5,SLCO1B1,ABCG8,SCARB1,AQP8,SLC22A7,ABCB1,SLC51B,SLC2A1,ABCC4,ADCY1,FXYD2,SLC9A1,RXRA,ABCB4,SLC4A4,UGT2B4,ADCY2,KCNN2,ADCY4,ATP1B3,ATP1A3,SULT2A1,SLC22A8,AQP9,HMGCR,GNAS,EPHX1,SLC51A,ADCY8,ABCC2,BAAT,ATP1A4,AQP4,ADCY9,CYP3A4,ADCY3,PRKACA,ABCG2,ABCC3,NR1H4,NCEH1,PRKACB,ADCY7,SLCO1B3
hsa04976	Bile secretion	0.00622764938355165	-5.07875632339157	71	69	0.010952380952381	6300	7161	196883,5244,6256,108,3781,8671,7363,9376,366,483,478,6822,114,1244,570,480,361,3156,2778,2052,200931,9971,57552,8714,9429,28234,113,5567,115,109,1576,5566,476,5568,57835,481,6554,112,1080,6579,8647,760,6523,6344,8431,6580,6522,1581,358,949,343,10864,5243,482,64240,3949,477,6550,111,6555,338821,64241,10599,486,6548,6513,123264,10257,107	ADCY4,ABCB4,RXRA,ADCY2,KCNN2,SLC4A4,UGT2B4,SLC22A8,AQP9,ATP1B3,ATP1A3,SULT2A1,ADCY8,ABCC2,BAAT,ATP1A4,AQP4,HMGCR,GNAS,EPHX1,SLC51A,NR1H4,NCEH1,ABCC3,ABCG2,SLCO1B3,ADCY7,PRKACB,ADCY9,ADCY3,CYP3A4,PRKACA,ATP1A1,PRKACG,SLC4A5,ATP1B1,SLC10A1,ADCY6,CFTR,SLCO1A2,ABCB11,CA2,SLC5A1,SCTR,NR0B2,SLC22A1,SLC4A2,CYP7A1,AQP1,SCARB1,AQP8,SLC22A7,ABCB1,ATP1B2,ABCG5,LDLR,ATP1A2,SLC9A3,ADCY5,SLC10A2,SLCO1B7,ABCG8,SLCO1B1,FXYD2,SLC9A1,SLC2A1,SLC51B,ABCC4,ADCY1
hsa05161	Hepatitis B	0.00693603628998032	-4.97102480739816	144	136	0.0215873015873016	6300	7161	5605,5594,7042,7043,7124,1870,64764,332,64135,3444,836,10000,4893,1147,6773,6772,208,841,2033,4792,5604,6777,5595,7529,54205,5290,3445,596,90993,3661,1388,1019,3339,3439,10488,29110,1387,7040,5894,6416,1959,4615,148022,6778,3665,3441,4609,1017,3452,5601,1021,4790,355,4773,4772,100506742,6714,9586,207,5111,2885,5925,581,468,5293,3716,3845,1026,356,5579,7534,842,114609,3454,7419,3576,5728,3569,4775,6776,57506,7097,7157,3725,8900,148327,5295,4089,7046,7099,3440,10542,3448,1385,1386,8503,9641,1643,5602,1642,8772,5599,1869,3551,5296,4318,84699,5291,3265,3449,2353,317,6775,4776,595,10971,2185,7098,5582,5970,4088,1960,3456,23586,5578,1871,9134,898,4214,6774,353376,1027,3442,3443,843,890	MAP2K2,MAPK1,TGFB2,TGFB3,TNF,E2F2,CREB3L2,BIRC5,IFIH1,IFNA7,CASP3,AKT3,NRAS,CHUK,STAT2,STAT1,AKT2,CASP8,EP300,NFKBIA,MAP2K1,STAT5B,MAPK3,YWHAB,CYCS,PIK3CA,IFNA8,BCL2,CREB3L1,IRF3,ATF6B,CDK4,HSPG2,IFNA1,CREB3,TBK1,CREBBP,TGFB1,RAF1,MAP2K4,EGR2,MYD88,TICAM1,STAT6,IRF7,IFNA4,MYC,CDK2,IFNA21,MAPK9,CDK6,NFKB1,FAS,NFATC2,NFATC1,CASP12,SRC,CREB5,AKT1,PCNA,GRB2,RB1,BAX,ATF4,PIK3CD,JAK1,KRAS,CDKN1A,FASLG,PRKCB,YWHAZ,CASP9,TIRAP,IFNAR1,VDAC3,CXCL8,PTEN,IL6,NFATC3,STAT5A,MAVS,TLR2,TP53,JUN,CCNA1,CREB3L4,PIK3R1,SMAD4,TGFBR1,TLR4,IFNA2,LAMTOR5,IFNA14,CREB1,ATF2,PIK3R3,IKBKE,DDB2,MAPK10,DDB1,FADD,MAPK8,E2F1,IKBKB,PIK3R2,MMP9,CREB3L3,PIK3CB,HRAS,IFNA16,FOS,APAF1,STAT4,NFATC4,CCND1,YWHAQ,PTK2B,TLR3,PRKCG,RELA,SMAD3,EGR3,IFNB1,RIGI,PRKCA,E2F3,CCNE2,CCNE1,MAP3K1,STAT3,TICAM2,CDKN1B,IFNA5,IFNA6,CASP10,CCNA2
ko04713	Circadian entrainment	0.00712080106413319	-4.94473505087945	96	92	0.0146031746031746	6300	7161	2773,5593,5592,9722,2790,5578,816,5332,107,6261,117,3762,776,3763,4543,112,801,5582,2903,51655,2788,2890,2982,2983,23236,2353,59345,2787,2792,2793,2778,2770,5330,109,5566,115,54331,1385,8911,113,8864,3760,108,4842,196883,3710,5579,2783,2893,2782,2977,111,2906,3708,94235,2784,9252,817,91860,2771,5331,5568,10681,8863,2776,6262,6263,5595,4544,2786,55811,114,818,2891,2904,51764,5567,163688,808,3765,810,2791,805,5594,55970,815,51806,2905,775,8912,8913,5187	GNAI3,PRKG2,PRKG1,NOS1AP,GNG10,PRKCA,CAMK2B,PLCB4,ADCY1,RYR1,ADCYAP1R1,KCNJ5,CACNA1D,KCNJ6,MTNR1A,ADCY6,CALM1,PRKCG,GRIN2A,RASD1,GNG7,GRIA1,GUCY1A1,GUCY1B1,PLCB1,FOS,GNB4,GNG5,GNGT1,GNGT2,GNAS,GNAI1,PLCB2,ADCY3,PRKACA,ADCY9,GNG2,CREB1,CACNA1I,ADCY7,PER2,KCNJ3,ADCY2,NOS1,ADCY4,ITPR3,PRKCB,GNB2,GRIA4,GNB1,GUCY1A2,ADCY5,GRIN2D,ITPR1,GNG8,GNB3,RPS6KA5,CAMK2D,CALML4,GNAI2,PLCB3,PRKACG,GNB5,PER3,GNAQ,RYR2,RYR3,MAPK3,MTNR1B,GNG4,ADCY10,ADCY8,CAMK2G,GRIA2,GRIN2B,GNG13,PRKACB,CALML6,CALM3,KCNJ9,CALML3,GNG11,CALM2,MAPK1,GNG12,CAMK2A,CALML5,GRIN2C,CACNA1C,CACNA1H,CACNA1G,PER1
hsa04713	Circadian entrainment	0.00712080106413319	-4.94473505087945	96	92	0.0146031746031746	6300	7161	111,3708,2906,94235,9252,2784,2771,91860,817,10681,5568,5331,8863,6263,6262,2776,5595,114,55811,2786,4544,2891,818,3765,810,808,5567,163688,51764,2904,805,2791,815,55970,5594,2905,51806,8913,5187,8912,775,2790,5578,9722,5592,5593,2773,5332,816,107,3763,3762,776,117,6261,4543,112,2890,2788,51655,2903,5582,801,59345,2353,23236,2983,2982,2778,2770,2793,2792,2787,5330,1385,115,54331,5566,109,3760,8864,113,8911,108,3710,5579,196883,4842,2893,2782,2783,2977	ADCY5,ITPR1,GRIN2D,GNG8,RPS6KA5,GNB3,GNAI2,CALML4,CAMK2D,GNB5,PRKACG,PLCB3,PER3,RYR3,RYR2,GNAQ,MAPK3,ADCY8,ADCY10,GNG4,MTNR1B,GRIA2,CAMK2G,KCNJ9,CALML3,CALM3,PRKACB,CALML6,GNG13,GRIN2B,CALM2,GNG11,CAMK2A,GNG12,MAPK1,GRIN2C,CALML5,CACNA1G,PER1,CACNA1H,CACNA1C,GNG10,PRKCA,NOS1AP,PRKG1,PRKG2,GNAI3,PLCB4,CAMK2B,ADCY1,KCNJ6,KCNJ5,CACNA1D,ADCYAP1R1,RYR1,MTNR1A,ADCY6,GRIA1,GNG7,RASD1,GRIN2A,PRKCG,CALM1,GNB4,FOS,PLCB1,GUCY1B1,GUCY1A1,GNAS,GNAI1,GNGT2,GNGT1,GNG5,PLCB2,CREB1,ADCY9,GNG2,PRKACA,ADCY3,KCNJ3,PER2,ADCY7,CACNA1I,ADCY2,ITPR3,PRKCB,ADCY4,NOS1,GRIA4,GNB1,GNB2,GUCY1A2
hsa04310	Wnt signaling pathway	0.00748914161347443	-4.89430109236312	143	135	0.0214285714285714	6300	7161	1499,7478,5601,4772,324,387,4773,8324,27101,9475,1459,1457,80326,64321,27123,50964,4040,5331,1452,5568,25805,8061,8325,817,1387,1487,23500,23002,80319,894,166336,85407,7483,7482,6422,6423,6500,6477,4609,8321,2033,7473,7472,27121,8313,8312,5535,896,11211,1857,5567,59343,11197,4316,5881,818,8326,1488,57216,5467,5534,54361,815,283106,7479,8454,7477,2535,144165,7480,6932,5663,89780,57680,816,2932,8607,5332,7475,7855,147111,5532,5533,5176,5578,7481,56998,6934,81029,5602,1855,5599,5879,7474,81839,9978,23236,5880,85409,4776,595,4088,5582,23291,4775,7976,22943,5330,9350,1454,122011,7157,27130,3725,5530,6424,4089,1856,5566,7484,7471,8323,51176,8322,5579,51384,10023,10297,6885,8945,6425,7476,79718,83439,4041	CTNNB1,WNT8A,MAPK9,NFATC1,APC,RHOA,NFATC2,FZD7,CACYBP,ROCK2,CSNK2A2,CSNK2A1,WNT10A,SOX17,DKK2,SOST,LRP6,PLCB3,CSNK1A1,PRKACG,BAMBI,FOSL1,FZD8,CAMK2D,CREBBP,CTBP1,DAAM2,DAAM1,CXXC4,CCND2,PRICKLE2,NKD1,WNT9A,WNT2B,SFRP1,SFRP2,SKP1,SIAH1,MYC,FZD1,EP300,WNT3,WNT2,DKK4,AXIN2,AXIN1,PPP3R2,CCND3,FZD10,DVL3,PRKACB,SENP2,WIF1,MMP7,RAC3,CAMK2G,FZD9,CTBP2,VANGL2,PPARD,PPP3R1,WNT4,CAMK2A,CSNK2A3,WNT8B,CUL1,WNT7B,FZD2,PRICKLE1,WNT10B,TCF7,PSEN1,WNT3A,CHD8,CAMK2B,GSK3B,RUVBL1,PLCB4,WNT6,FZD5,NOTUM,PPP3CB,PPP3CC,SERPINF1,PRKCA,WNT11,CTNNBIP1,TCF7L2,WNT5B,MAPK10,DVL1,MAPK8,RAC1,WNT5A,VANGL1,RBX1,PLCB1,RAC2,NKD2,NFATC4,CCND1,SMAD3,PRKCG,FBXW11,NFATC3,FZD3,DKK1,PLCB2,CER1,CSNK1E,CSNK1A1L,TP53,INVS,JUN,PPP3CA,SFRP4,SMAD4,DVL2,PRKACA,WNT9B,WNT1,FZD6,LEF1,FZD4,PRKCB,WNT16,FRAT1,APC2,MAP3K7,BTRC,SFRP5,WNT7A,TBL1XR1,TCF7L1,LRP5
ko04310	Wnt signaling pathway	0.00748914161347443	-4.89430109236312	143	135	0.0214285714285714	6300	7161	283106,7479,54361,5534,815,8454,7477,144165,2535,5663,89780,7480,6932,27121,5535,896,8313,8312,8321,7473,7472,2033,1488,818,8326,5467,57216,5567,59343,11211,1857,5881,11197,4316,1387,817,23500,23002,1487,5331,25805,8325,8061,1452,5568,6500,6422,6423,6477,4609,894,80319,7483,7482,166336,85407,27101,8324,9475,1459,1499,387,324,4772,4773,7478,5601,4040,50964,80326,1457,27123,64321,10023,51384,7471,5579,51176,8323,8322,6425,7476,6885,8945,4041,83439,79718,10297,122011,1454,27130,5530,3725,7157,22943,5330,9350,4775,7976,5566,7484,1856,6424,4089,5879,7474,81839,81029,5602,1855,5599,4776,595,23291,4088,5582,5880,23236,9978,85409,147111,7855,5176,5578,5532,5533,816,2932,57680,8607,5332,7475,6934,7481,56998	CSNK2A3,WNT8B,WNT4,PPP3R1,CAMK2A,CUL1,WNT7B,PRICKLE1,FZD2,PSEN1,WNT3A,WNT10B,TCF7,DKK4,PPP3R2,CCND3,AXIN2,AXIN1,FZD1,WNT3,WNT2,EP300,CTBP2,CAMK2G,FZD9,PPARD,VANGL2,PRKACB,SENP2,FZD10,DVL3,RAC3,WIF1,MMP7,CREBBP,CAMK2D,DAAM2,DAAM1,CTBP1,PLCB3,BAMBI,FZD8,FOSL1,CSNK1A1,PRKACG,SKP1,SFRP1,SFRP2,SIAH1,MYC,CCND2,CXXC4,WNT9A,WNT2B,PRICKLE2,NKD1,CACYBP,FZD7,ROCK2,CSNK2A2,CTNNB1,RHOA,APC,NFATC1,NFATC2,WNT8A,MAPK9,LRP6,SOST,WNT10A,CSNK2A1,DKK2,SOX17,FRAT1,WNT16,WNT1,PRKCB,LEF1,FZD6,FZD4,SFRP5,WNT7A,MAP3K7,BTRC,LRP5,TCF7L1,TBL1XR1,APC2,CSNK1A1L,CSNK1E,INVS,PPP3CA,JUN,TP53,DKK1,PLCB2,CER1,NFATC3,FZD3,PRKACA,WNT9B,DVL2,SFRP4,SMAD4,RAC1,WNT5A,VANGL1,WNT5B,MAPK10,DVL1,MAPK8,NFATC4,CCND1,FBXW11,SMAD3,PRKCG,RAC2,PLCB1,RBX1,NKD2,NOTUM,FZD5,SERPINF1,PRKCA,PPP3CB,PPP3CC,CAMK2B,GSK3B,CHD8,RUVBL1,PLCB4,WNT6,TCF7L2,WNT11,CTNNBIP1
hsa_M00677	Wnt signaling	0.00758739466007846	-4.88126700604334	38	38	0.00603174603174603	6300	7161	1856,6934,8326,7484,11211,7481,1857,80326,7855,8324,2932,8321,1499,7478,7475,7976,7473,7472,7476,83439,7477,2535,7480,6932,7483,89780,7482,7474,51384,7479,7471,81029,54361,51176,8323,8322,1855,8325	DVL2,TCF7L2,FZD9,WNT9B,FZD10,WNT11,DVL3,WNT10A,FZD5,FZD7,GSK3B,FZD1,CTNNB1,WNT8A,WNT6,FZD3,WNT3,WNT2,WNT7A,TCF7L1,WNT7B,FZD2,WNT10B,TCF7,WNT9A,WNT3A,WNT2B,WNT5A,WNT16,WNT8B,WNT1,WNT5B,WNT4,LEF1,FZD6,FZD4,DVL1,FZD8
M00677	Wnt signaling	0.00758739466007846	-4.88126700604334	38	38	0.00603174603174603	6300	7161	81029,54361,7471,1855,8325,8323,51176,8322,7474,51384,7479,7477,2535,7483,89780,7482,7480,6932,7476,83439,2932,8321,1499,7473,7472,7478,7475,7976,7855,8324,80326,11211,1857,7481,7484,1856,8326,6934	WNT5B,WNT4,WNT1,DVL1,FZD8,FZD6,LEF1,FZD4,WNT5A,WNT16,WNT8B,WNT7B,FZD2,WNT9A,WNT3A,WNT2B,WNT10B,TCF7,WNT7A,TCF7L1,GSK3B,FZD1,CTNNB1,WNT3,WNT2,WNT8A,WNT6,FZD3,FZD5,FZD7,WNT10A,FZD10,DVL3,WNT11,WNT9B,DVL2,FZD9,TCF7L2
ko04115	p53 signaling pathway	0.00765762133145855	-4.8720538745956	69	67	0.0106349206349206	6300	7161	5054,10912,1026,9134,8493,581,51246,898,1647,25898,1029,27244,3486,1021,545,355,7161,595,472,5268,1017,83667,6477,27113,64326,894,11200,51512,317,4194,92344,64065,7249,8795,1019,1643,63970,901,1111,56475,143686,5366,54205,9540,55240,7157,4616,896,55367,841,5728,9538,900,983,4193,7057,3732,9133,891,50484,575,836,842,6241,64393,2810,3479	SERPINE1,GADD45G,CDKN1A,CCNE2,PPM1D,BAX,SHISA5,CCNE1,GADD45A,RCHY1,CDKN2A,SESN1,IGFBP3,CDK6,ATR,FAS,TP73,CCND1,ATM,SERPINB5,CDK2,SESN2,SIAH1,BBC3,COP1,CCND2,CHEK2,GTSE1,APAF1,MDM4,GORAB,PERP,TSC2,TNFRSF10B,CDK4,DDB2,TP53AIP1,CCNG2,CHEK1,RPRM,SESN3,PMAIP1,CYCS,TP53I3,STEAP3,TP53,GADD45B,CCND3,PIDD1,CASP8,PTEN,EI24,CCNG1,CDK1,MDM2,THBS1,CD82,CCNB2,CCNB1,RRM2B,ADGRB1,CASP3,CASP9,RRM2,ZMAT3,SFN,IGF1
hsa04115	p53 signaling pathway	0.00765762133145855	-4.8720538745956	69	67	0.0106349206349206	6300	7161	842,6241,64393,2810,3479,3732,891,9133,50484,575,836,55240,4616,7157,896,55367,5728,841,9538,900,983,4193,7057,56475,143686,5366,54205,9540,4194,92344,64065,7249,8795,1019,1643,63970,901,1111,7161,595,472,5268,83667,1017,6477,27113,894,64326,51512,11200,317,25898,1029,27244,3486,1021,545,355,5054,10912,1026,581,8493,9134,898,51246,1647	CASP9,RRM2,ZMAT3,SFN,IGF1,CD82,CCNB1,CCNB2,RRM2B,ADGRB1,CASP3,STEAP3,GADD45B,TP53,CCND3,PIDD1,PTEN,CASP8,EI24,CCNG1,CDK1,MDM2,THBS1,RPRM,SESN3,PMAIP1,CYCS,TP53I3,MDM4,GORAB,PERP,TSC2,TNFRSF10B,CDK4,DDB2,TP53AIP1,CCNG2,CHEK1,TP73,CCND1,ATM,SERPINB5,SESN2,CDK2,SIAH1,BBC3,CCND2,COP1,GTSE1,CHEK2,APAF1,RCHY1,CDKN2A,SESN1,IGFBP3,CDK6,ATR,FAS,SERPINE1,GADD45G,CDKN1A,BAX,PPM1D,CCNE2,CCNE1,SHISA5,GADD45A
hsa01522	Endocrine resistance	0.007796148207872	-4.85412548675919	95	91	0.0144444444444444	6300	7161	109,5566,115,113,5295,7157,3725,25759,2778,4193,6198,2852,4313,108,9611,196883,5600,107,6655,6199,4854,1027,1029,6667,1871,4855,595,5291,3265,2353,6654,1869,5296,4318,8503,112,5602,5603,1956,5599,596,5567,5747,5290,3714,6464,5604,5595,10498,54567,5469,1839,2064,114,10683,4853,208,3480,10000,4893,638,1031,1870,2099,5594,5605,3479,53358,3845,1026,581,182,5293,111,1565,6714,207,2885,5925,5601,8202,2475,6300,2100,673,1432,399694,5894,8647,1019,5568	ADCY3,PRKACA,ADCY9,ADCY7,PIK3R1,TP53,JUN,SHC2,GNAS,MDM2,RPS6KB1,GPER1,MMP2,ADCY2,NCOR1,ADCY4,MAPK11,ADCY1,SOS2,RPS6KB2,NOTCH3,CDKN1B,CDKN2A,SP1,E2F3,NOTCH4,CCND1,PIK3CB,HRAS,FOS,SOS1,E2F1,PIK3R2,MMP9,PIK3R3,ADCY6,MAPK10,MAPK13,EGFR,MAPK8,BCL2,PRKACB,PTK2,PIK3CA,JAG2,SHC1,MAP2K1,MAPK3,CARM1,DLL4,MED1,HBEGF,ERBB2,ADCY8,DLL3,NOTCH2,AKT2,IGF1R,AKT3,NRAS,BIK,CDKN2C,E2F2,ESR1,MAPK1,MAP2K2,IGF1,SHC3,KRAS,CDKN1A,BAX,JAG1,PIK3CD,ADCY5,CYP2D6,SRC,AKT1,GRB2,RB1,MAPK9,NCOA3,MTOR,MAPK12,ESR2,BRAF,MAPK14,SHC4,RAF1,ABCB11,CDK4,PRKACG
ko01522	Endocrine resistance	0.007796148207872	-4.85412548675919	95	91	0.0144444444444444	6300	7161	8202,2475,673,2100,6300,399694,1432,8647,5894,1019,5568,3845,1026,182,581,5293,111,5925,2885,207,6714,1565,5601,4853,10683,3480,208,638,1031,4893,10000,1870,2099,5594,5605,53358,3479,596,5567,5747,5290,3714,54567,10498,5595,5604,6464,2064,1839,5469,114,595,4855,3265,5291,6654,2353,4318,5296,1869,5603,5602,112,8503,1956,5599,107,6655,6199,1027,4854,6667,1029,1871,6198,2852,108,4313,9611,5600,196883,5566,109,115,113,5295,2778,25759,3725,7157,4193	NCOA3,MTOR,BRAF,ESR2,MAPK12,SHC4,MAPK14,ABCB11,RAF1,CDK4,PRKACG,KRAS,CDKN1A,JAG1,BAX,PIK3CD,ADCY5,RB1,GRB2,AKT1,SRC,CYP2D6,MAPK9,NOTCH2,DLL3,IGF1R,AKT2,BIK,CDKN2C,NRAS,AKT3,E2F2,ESR1,MAPK1,MAP2K2,SHC3,IGF1,BCL2,PRKACB,PTK2,PIK3CA,JAG2,DLL4,CARM1,MAPK3,MAP2K1,SHC1,ERBB2,HBEGF,MED1,ADCY8,CCND1,NOTCH4,HRAS,PIK3CB,SOS1,FOS,MMP9,PIK3R2,E2F1,MAPK13,MAPK10,ADCY6,PIK3R3,EGFR,MAPK8,ADCY1,SOS2,RPS6KB2,CDKN1B,NOTCH3,SP1,CDKN2A,E2F3,RPS6KB1,GPER1,ADCY2,MMP2,NCOR1,MAPK11,ADCY4,PRKACA,ADCY3,ADCY9,ADCY7,PIK3R1,GNAS,SHC2,JUN,TP53,MDM2
hsa04923	Regulation of lipolysis in adipocytes	0.00813511846171909	-4.81156497643571	54	53	0.00841269841269841	6300	7161	5566,109,115,5567,113,3630,5295,5290,2770,2778,3667,1081,114,4852,4886,208,5733,10000,108,196883,4881,5743,5742,51099,107,7252,7253,2167,5293,3991,11145,111,364,5592,2773,207,5593,3643,154,134,5291,11343,57104,5296,2771,5346,153,8503,155,112,5140,8660,5568	PRKACA,ADCY3,ADCY9,PRKACB,ADCY7,INS,PIK3R1,PIK3CA,GNAI1,GNAS,IRS1,CGA,ADCY8,NPY,NPY1R,AKT2,PTGER3,AKT3,ADCY2,ADCY4,NPR1,PTGS2,PTGS1,ABHD5,ADCY1,TSHB,TSHR,FABP4,PIK3CD,LIPE,PLAAT3,ADCY5,AQP7,PRKG1,GNAI3,AKT1,PRKG2,INSR,ADRB2,ADORA1,PIK3CB,MGLL,PNPLA2,PIK3R2,GNAI2,PLIN1,ADRB1,PIK3R3,ADRB3,ADCY6,PDE3B,IRS2,PRKACG
hsa05146	Amoebiasis	0.00853223137687335	-4.76390436002609	94	90	0.0142857142857143	6300	7161	3458,383,1285,3908,3911,5747,5567,5273,5272,5290,1511,1284,22798,2774,7124,7042,5868,7043,2919,836,2335,732,3592,3593,5869,735,3914,912,4790,4583,3689,7850,3553,2769,3315,929,2767,1992,284217,5293,1437,5331,3909,5568,7040,1281,3915,7879,1286,2776,7414,81,5878,3569,5330,7097,1277,3684,2778,9630,731,384,5269,6318,5295,7099,5566,3554,5579,3913,3912,3576,5332,10319,5578,1282,3586,5275,107,8503,6317,5296,3910,3918,23236,5291,87,1278,5970,5582	IFNG,ARG1,COL4A3,LAMA2,LAMA5,PTK2,PRKACB,SERPINB10,SERPINB9,PIK3CA,CTSG,COL4A2,LAMB4,GNAL,TNF,TGFB2,RAB5A,TGFB3,CXCL1,CASP3,FN1,C8B,IL12A,IL12B,RAB5B,C9,LAMB3,CD1D,NFKB1,MUC2,ITGB2,IL1R2,IL1B,GNA15,HSPB1,CD14,GNA11,SERPINB1,LAMA1,PIK3CD,CSF2,PLCB3,LAMA3,PRKACG,TGFB1,COL3A1,LAMC1,RAB7A,COL4A4,GNAQ,VCL,ACTN4,RAB5C,IL6,PLCB2,TLR2,COL1A1,ITGAM,GNAS,GNA14,C8A,ARG2,SERPINB6,SERPINB4,PIK3R1,TLR4,PRKACA,IL1R1,PRKCB,LAMB2,LAMB1,CXCL8,PLCB4,LAMC3,PRKCA,COL4A1,IL10,SERPINB13,ADCY1,PIK3R3,SERPINB3,PIK3R2,LAMA4,LAMC2,PLCB1,PIK3CB,ACTN1,COL1A2,RELA,PRKCG
ko05146	Amoebiasis	0.00853223137687335	-4.76390436002609	94	90	0.0142857142857143	6300	7161	7043,7042,5868,7124,2774,1284,22798,732,2335,2919,836,3911,3908,1285,3458,383,1511,5747,5567,5290,5272,5273,3915,1281,7040,7879,5331,5568,3909,7414,2776,1286,81,7850,3689,4583,2769,3553,5869,3593,3592,4790,912,3914,735,1437,929,2767,3315,5293,284217,1992,3912,3913,3554,5579,3576,1277,7097,2778,3684,3569,5878,5330,5566,384,731,9630,7099,5295,5269,6318,3910,3918,5296,6317,8503,5582,5970,1278,5291,23236,87,10319,3586,5578,1282,5332,107,5275	TGFB3,TGFB2,RAB5A,TNF,GNAL,COL4A2,LAMB4,C8B,FN1,CXCL1,CASP3,LAMA5,LAMA2,COL4A3,IFNG,ARG1,CTSG,PTK2,PRKACB,PIK3CA,SERPINB9,SERPINB10,LAMC1,COL3A1,TGFB1,RAB7A,PLCB3,PRKACG,LAMA3,VCL,GNAQ,COL4A4,ACTN4,IL1R2,ITGB2,MUC2,GNA15,IL1B,RAB5B,IL12B,IL12A,NFKB1,CD1D,LAMB3,C9,CSF2,CD14,GNA11,HSPB1,PIK3CD,LAMA1,SERPINB1,LAMB1,LAMB2,IL1R1,PRKCB,CXCL8,COL1A1,TLR2,GNAS,ITGAM,IL6,RAB5C,PLCB2,PRKACA,ARG2,C8A,GNA14,TLR4,PIK3R1,SERPINB6,SERPINB4,LAMA4,LAMC2,PIK3R2,SERPINB3,PIK3R3,PRKCG,RELA,COL1A2,PIK3CB,PLCB1,ACTN1,LAMC3,IL10,PRKCA,COL4A1,PLCB4,ADCY1,SERPINB13
ko04664	Fc epsilon RI signaling pathway	0.00940252024999248	-4.66677751394037	67	65	0.0103174603174603	6300	7161	6654,6300,5880,5291,3265,3596,5336,5599,5602,5603,8503,2207,5894,6416,5296,5879,3565,2206,1432,5293,7409,4067,5606,7410,1437,3845,6655,5601,3937,5578,2885,207,240,5609,4893,10000,8605,5170,255189,208,9846,5594,5605,5608,5600,241,283748,7124,3562,2205,5881,5295,5290,3635,5321,2534,3567,10451,100137049,5335,27040,123745,6850,5595,5604	SOS1,MAPK12,RAC2,PIK3CB,HRAS,IL13,PLCG2,MAPK8,MAPK10,MAPK13,PIK3R3,FCER1G,RAF1,MAP2K4,PIK3R2,RAC1,IL4,MS4A2,MAPK14,PIK3CD,VAV1,LYN,MAP2K3,VAV2,CSF2,KRAS,SOS2,MAPK9,LCP2,PRKCA,GRB2,AKT1,ALOX5,MAP2K7,NRAS,AKT3,PLA2G4C,PDPK1,PLA2G4F,AKT2,GAB2,MAPK1,MAP2K2,MAP2K6,MAPK11,ALOX5AP,PLA2G4D,TNF,IL3,FCER1A,RAC3,PIK3R1,PIK3CA,INPP5D,PLA2G4A,FYN,IL5,VAV3,PLA2G4B,PLCG1,LAT,PLA2G4E,SYK,MAPK3,MAP2K1
hsa04664	Fc epsilon RI signaling pathway	0.00940252024999248	-4.66677751394037	67	65	0.0103174603174603	6300	7161	1432,2206,3565,5879,5296,6416,5894,2207,8503,5603,5602,5599,5336,3596,3265,5291,5880,6300,6654,5609,240,207,5578,2885,3937,5601,6655,3845,1437,7410,5606,4067,7409,5293,3562,7124,283748,241,5608,5600,5605,5594,9846,208,255189,5170,8605,10000,4893,5604,5595,6850,123745,5335,27040,100137049,10451,2534,3567,3635,5321,5290,5295,5881,2205	MAPK14,MS4A2,IL4,RAC1,PIK3R2,MAP2K4,RAF1,FCER1G,PIK3R3,MAPK13,MAPK10,MAPK8,PLCG2,IL13,HRAS,PIK3CB,RAC2,MAPK12,SOS1,MAP2K7,ALOX5,AKT1,PRKCA,GRB2,LCP2,MAPK9,SOS2,KRAS,CSF2,VAV2,MAP2K3,LYN,VAV1,PIK3CD,IL3,TNF,PLA2G4D,ALOX5AP,MAP2K6,MAPK11,MAP2K2,MAPK1,GAB2,AKT2,PLA2G4F,PDPK1,PLA2G4C,AKT3,NRAS,MAP2K1,MAPK3,SYK,PLA2G4E,PLCG1,LAT,PLA2G4B,VAV3,FYN,IL5,INPP5D,PLA2G4A,PIK3CA,PIK3R1,RAC3,FCER1A
hsa04724	Glutamatergic synapse	0.0119768985602061	-4.4247756046021	114	108	0.0171428571428571	6300	7161	2787,2897,2778,2770,1742,5530,2792,2793,2752,5330,156,5338,6506,5566,100137049,109,115,54331,113,2899,3760,108,283748,196883,3710,5579,2916,255189,2900,2911,2783,2893,2782,2790,5578,2773,5532,5533,5332,2915,107,22941,6512,81539,776,112,7220,10991,6505,2788,2898,2890,5582,2903,23236,5337,2744,59345,2914,50944,5535,27165,5595,6507,9229,9455,2786,123745,114,2891,116444,2913,2912,51764,5567,2904,57084,5321,3709,2791,2917,9454,157,5534,5594,55970,2905,773,116443,775,8605,246213,111,3708,2906,94235,2918,2901,2784,57030,54407,2771,5331,10681,5568,6511,9456,2776	GNG5,GRIK1,GNAS,GNAI1,DLG4,PPP3CA,GNGT1,GNGT2,GLUL,PLCB2,GRK2,PLD2,SLC1A2,PRKACA,PLA2G4B,ADCY3,ADCY9,GNG2,ADCY7,GRIK3,KCNJ3,ADCY2,PLA2G4D,ADCY4,ITPR3,PRKCB,GRM6,PLA2G4F,GRIK4,GRM1,GNB2,GRIA4,GNB1,GNG10,PRKCA,GNAI3,PPP3CB,PPP3CC,PLCB4,GRM5,ADCY1,SHANK2,SLC1A7,SLC38A1,CACNA1D,ADCY6,TRPC1,SLC38A3,SLC1A1,GNG7,GRIK2,GRIA1,PRKCG,GRIN2A,PLCB1,PLD1,GLS,GNB4,GRM4,SHANK1,PPP3R2,GLS2,MAPK3,SLC1A3,DLGAP1,HOMER2,GNG4,PLA2G4E,ADCY8,GRIA2,GRIN3B,GRM3,GRM2,GNG13,PRKACB,GRIN2B,SLC17A6,PLA2G4A,ITPR2,GNG11,GRM7,HOMER3,GRK3,PPP3R1,MAPK1,GNG12,GRIN2C,CACNA1A,GRIN3A,CACNA1C,PLA2G4C,SLC17A8,ADCY5,ITPR1,GRIN2D,GNG8,GRM8,GRIK5,GNB3,SLC17A7,SLC38A2,GNAI2,PLCB3,GNB5,PRKACG,SLC1A6,HOMER1,GNAQ
ko04724	Glutamatergic synapse	0.0119768985602061	-4.4247756046021	114	108	0.0171428571428571	6300	7161	776,81539,6512,22941,107,2915,5332,5533,5532,2773,5578,2790,2914,59345,2744,5337,23236,2903,5582,2898,2890,2788,6505,10991,7220,112,3760,2899,113,54331,115,109,100137049,5566,6506,5338,5330,156,2752,2793,2792,5530,1742,2778,2770,2897,2787,2782,2893,2783,2900,255189,2911,2916,5579,3710,196883,283748,108,57030,2784,94235,2918,2901,2906,3708,111,2776,9456,6511,5568,10681,5331,2771,54407,5321,2904,57084,5567,51764,2912,2913,116444,2891,114,123745,2786,9455,9229,6507,5595,27165,5535,50944,246213,8605,775,116443,773,2905,5594,55970,5534,157,9454,2917,3709,2791	CACNA1D,SLC38A1,SLC1A7,SHANK2,ADCY1,GRM5,PLCB4,PPP3CC,PPP3CB,GNAI3,PRKCA,GNG10,GRM4,GNB4,GLS,PLD1,PLCB1,GRIN2A,PRKCG,GRIK2,GRIA1,GNG7,SLC1A1,SLC38A3,TRPC1,ADCY6,KCNJ3,GRIK3,ADCY7,GNG2,ADCY9,ADCY3,PLA2G4B,PRKACA,SLC1A2,PLD2,PLCB2,GRK2,GLUL,GNGT2,GNGT1,PPP3CA,DLG4,GNAS,GNAI1,GRIK1,GNG5,GNB1,GRIA4,GNB2,GRIK4,PLA2G4F,GRM1,GRM6,PRKCB,ITPR3,ADCY4,PLA2G4D,ADCY2,SLC17A7,GNB3,GNG8,GRM8,GRIK5,GRIN2D,ITPR1,ADCY5,GNAQ,HOMER1,SLC1A6,PRKACG,GNB5,PLCB3,GNAI2,SLC38A2,PLA2G4A,GRIN2B,SLC17A6,PRKACB,GNG13,GRM2,GRM3,GRIN3B,GRIA2,ADCY8,PLA2G4E,GNG4,HOMER2,DLGAP1,SLC1A3,MAPK3,GLS2,PPP3R2,SHANK1,SLC17A8,PLA2G4C,CACNA1C,GRIN3A,CACNA1A,GRIN2C,MAPK1,GNG12,PPP3R1,GRK3,HOMER3,GRM7,ITPR2,GNG11
ko05142	Chagas disease (American trypanosomiasis)	0.0122409467121739	-4.40296865912315	102	97	0.0153968253968254	6300	7161	207,2769,3553,3593,3592,4790,5601,355,2767,5518,5293,3459,1432,7040,7048,2771,6416,5331,2776,4615,6300,917,148022,51135,3558,5595,841,3458,624,6352,4792,5521,5290,7043,7042,714,7124,2774,54106,5594,1147,915,208,5519,10000,919,1636,2773,3586,712,5332,107,5054,6348,916,5515,3551,5296,8503,5603,8772,5602,3460,5599,5520,4088,5970,3456,5291,23236,811,2353,4087,7097,718,2778,2770,3725,3569,5330,10333,9630,7099,5295,7046,5516,6347,7189,414062,356,5600,8837,713,3576,5522,6349,7132	AKT1,GNA15,IL1B,IL12B,IL12A,NFKB1,MAPK9,FAS,GNA11,PPP2R1A,PIK3CD,IFNGR1,MAPK14,TGFB1,TGFBR2,GNAI2,MAP2K4,PLCB3,GNAQ,MYD88,MAPK12,CD3G,TICAM1,IRAK4,IL2,MAPK3,CASP8,IFNG,BDKRB2,CCL5,NFKBIA,PPP2R2B,PIK3CA,TGFB3,TGFB2,C1QC,TNF,GNAL,TLR9,MAPK1,CHUK,CD3D,AKT2,PPP2R1B,AKT3,CD247,ACE,GNAI3,IL10,C1QA,PLCB4,ADCY1,SERPINE1,CCL3,CD3E,PPP2CA,IKBKB,PIK3R2,PIK3R3,MAPK13,FADD,MAPK10,IFNGR2,MAPK8,PPP2R2A,SMAD3,RELA,IFNB1,PIK3CB,PLCB1,CALR,FOS,SMAD2,TLR2,C3,GNAS,GNAI1,JUN,IL6,PLCB2,TLR6,GNA14,TLR4,PIK3R1,TGFBR1,PPP2CB,CCL2,TRAF6,CCL3L3,FASLG,MAPK11,CFLAR,C1QB,CXCL8,PPP2R2C,CCL3L1,TNFRSF1A
hsa05142	Chagas disease (American trypanosomiasis)	0.0122409467121739	-4.40296865912315	102	97	0.0153968253968254	6300	7161	5296,3551,5599,3460,5602,8772,5603,8503,3456,5520,5970,4088,2353,23236,811,5291,712,3586,2773,1636,5332,916,6348,5054,107,5515,7189,414062,6347,5516,8837,356,5600,5522,3576,713,7132,6349,3725,2778,2770,718,7097,4087,5330,3569,5295,7046,7099,9630,10333,6416,2771,7048,7040,1432,3459,5331,148022,917,6300,4615,2776,3553,2769,207,355,5601,4790,3592,3593,5293,5518,2767,7124,714,7042,7043,2774,54106,5594,5519,208,915,1147,919,10000,5595,3558,51135,4792,6352,624,3458,841,5521,5290	PIK3R2,IKBKB,MAPK8,IFNGR2,MAPK10,FADD,MAPK13,PIK3R3,IFNB1,PPP2R2A,RELA,SMAD3,FOS,PLCB1,CALR,PIK3CB,C1QA,IL10,GNAI3,ACE,PLCB4,CD3E,CCL3,SERPINE1,ADCY1,PPP2CA,TRAF6,CCL3L3,CCL2,PPP2CB,CFLAR,FASLG,MAPK11,PPP2R2C,CXCL8,C1QB,TNFRSF1A,CCL3L1,JUN,GNAS,GNAI1,C3,TLR2,SMAD2,PLCB2,IL6,PIK3R1,TGFBR1,TLR4,GNA14,TLR6,MAP2K4,GNAI2,TGFBR2,TGFB1,MAPK14,IFNGR1,PLCB3,TICAM1,CD3G,MAPK12,MYD88,GNAQ,IL1B,GNA15,AKT1,FAS,MAPK9,NFKB1,IL12A,IL12B,PIK3CD,PPP2R1A,GNA11,TNF,C1QC,TGFB2,TGFB3,GNAL,TLR9,MAPK1,PPP2R1B,AKT2,CD3D,CHUK,CD247,AKT3,MAPK3,IL2,IRAK4,NFKBIA,CCL5,BDKRB2,IFNG,CASP8,PPP2R2B,PIK3CA
ko04810	Regulation of actin cytoskeleton	0.0127909439957862	-4.35901785878223	211	196	0.0311111111111111	6300	7161	3683,10152,3682,10092,200576,4633,673,7414,375189,8817,387,2246,2259,4659,3687,5293,23191,8826,3845,2768,81873,2250,55970,5605,2934,4627,4893,79837,26999,5216,8874,93408,56034,1131,3679,3645,624,56924,5595,5881,8395,5159,5747,3630,3690,1950,1793,71,8822,8503,5879,5296,10109,3265,5291,5155,9564,3681,2260,4660,50649,998,2247,4636,5062,3675,28964,9965,6655,340156,5829,79784,60,10672,2255,2147,23396,5500,5217,55740,8516,8074,10093,3985,3684,27006,623,3695,221178,1133,1132,2252,2253,10095,5894,2264,8396,5058,81,9138,103910,324,22801,1729,9475,6714,89846,3689,80310,5501,929,3693,2257,7409,8936,3071,57144,4628,10094,2261,54961,3680,3688,5594,1398,4638,85464,91807,22808,8394,2335,5305,7430,10627,85477,5604,128239,81624,5290,5962,3673,7074,3672,8976,58498,85366,10458,26291,1956,4342,3696,10787,5499,10298,87,6654,10163,3691,55845,5880,3674,8515,1129,2251,22800,54776,2909,2249,5154,6548,1072,1073,7410,2256,23365,3685,345456,3676,3984,1128,6237,10297,10552,2149,10788,2248,3694,5156,2263,26281,2254,54434,5295,3655,10451,10398	ITGAL,ABI2,ITGAE,ARPC5,PIKFYVE,MYL2,BRAF,VCL,PFN4,FGF18,RHOA,FGF1,FGF14,PPP1R12A,ITGAX,PIK3CD,CYFIP1,IQGAP1,KRAS,GNA12,ARPC5L,FGF5,GNG12,MAP2K2,GSN,MYH9,NRAS,PIP4K2C,CYFIP2,PFN1,ARHGEF7,MYL10,PDGFC,CHRM3,ITGA7,INSRR,BDKRB2,PAK6,MAPK3,RAC3,PIP5K1B,PDGFRB,PTK2,INS,ITGB3,EGF,DOCK1,ACTG1,FGF17,PIK3R3,RAC1,PIK3R2,ARPC2,HRAS,PIK3CB,PDGFB,BCAR1,ITGAD,FGFR1,PPP1R12B,ARHGEF4,CDC42,FGF2,MYL5,PAK2,ITGA3,GIT1,FGF19,SOS2,MYLK4,PXN,MYH14,ACTB,GNA13,FGF10,F2,PIP5K1C,PPP1CB,PFN2,ENAH,ITGA8,FGF23,ARPC4,LIMK2,ITGAM,FGF22,BDKRB1,ITGB7,SPATA13,CHRM5,CHRM4,FGF7,FGF8,ARPC1B,RAF1,FGFR4,PIP4K2B,PAK1,ACTN4,ARHGEF1,MYL12B,APC,ITGA11,DIAPH1,ROCK2,SRC,FGD3,ITGB2,PDGFD,PPP1CC,CD14,ITGB5,FGF12,VAV1,WASF1,NCKAP1L,PAK5,MYH10,ARPC3,FGFR3,SSH3,ITGA9,ITGB1,MAPK1,CRK,MYLK,SSH2,MYLK3,MRAS,PIP5K1A,FN1,PIP4K2A,EZR,MYL12A,SCIN,MAP2K1,IQGAP3,DIAPH3,PIK3CA,RDX,ITGA2,TIAM1,ITGA1,WASL,MYL7,MYLK2,BAIAP2,FGF21,EGFR,MOS,ITGB8,NCKAP1,PPP1CA,PAK4,ACTN1,SOS1,WASF2,ITGB4,BRK1,RAC2,ITGA2B,ITGA10,CHRM2,FGF6,RRAS2,PPP1R12C,ARHGAP35,FGF4,PDGFA,SLC9A1,CFL1,CFL2,VAV2,FGF11,ARHGEF12,ITGAV,PFN3,ITGA4,LIMK1,CHRM1,RRAS,APC2,ARPC1A,F2R,IQGAP2,FGF3,ITGB6,PDGFRA,FGFR2,FGF20,FGF9,SSH1,PIK3R1,ITGA6,VAV3,MYL9
hsa04810	Regulation of actin cytoskeleton	0.0127909439957862	-4.35901785878223	211	196	0.0311111111111111	6300	7161	7410,2256,2909,2249,5154,6548,1072,1073,54776,8515,1129,2251,22800,3674,87,6654,10163,55845,3691,5880,3696,10787,5499,10298,10458,26291,1956,4342,3655,10451,10398,5295,26281,2254,54434,5156,2263,3694,2248,10297,10552,2149,10788,3676,3984,1128,6237,345456,3685,23365,57144,4628,10094,80310,5501,929,3693,7409,2257,8936,3071,9475,6714,89846,3689,324,22801,1729,9138,103910,5058,81,2264,5894,8396,2252,2253,10095,58498,85366,81624,5290,5962,3673,7074,3672,8976,5604,128239,10627,7430,85477,22808,2335,8394,5305,91807,1398,4638,85464,2261,54961,3680,3688,5594,28964,9965,6655,340156,5829,4636,5062,3675,998,2247,9564,3681,4660,2260,50649,5155,10109,3265,5291,5879,5296,71,8822,8503,1133,1132,623,3695,221178,3684,27006,8074,10093,3985,5217,55740,8516,5500,2147,23396,79784,60,10672,2255,8826,3845,3687,5293,23191,2259,4659,387,2246,8817,673,375189,7414,10092,200576,4633,10152,3683,3682,1950,1793,5881,8395,5159,5747,3630,3690,5595,3645,624,56924,8874,93408,56034,1131,3679,4893,79837,26999,5216,2934,4627,2768,81873,2250,55970,5605	VAV2,FGF11,ARHGAP35,FGF4,PDGFA,SLC9A1,CFL1,CFL2,PPP1R12C,ITGA10,CHRM2,FGF6,RRAS2,ITGA2B,ACTN1,SOS1,WASF2,BRK1,ITGB4,RAC2,ITGB8,NCKAP1,PPP1CA,PAK4,BAIAP2,FGF21,EGFR,MOS,ITGA6,VAV3,MYL9,PIK3R1,FGF20,FGF9,SSH1,PDGFRA,FGFR2,ITGB6,FGF3,APC2,ARPC1A,F2R,IQGAP2,ITGA4,LIMK1,CHRM1,RRAS,PFN3,ITGAV,ARHGEF12,PAK5,MYH10,ARPC3,PDGFD,PPP1CC,CD14,ITGB5,VAV1,FGF12,WASF1,NCKAP1L,ROCK2,SRC,FGD3,ITGB2,APC,ITGA11,DIAPH1,ARHGEF1,MYL12B,PAK1,ACTN4,FGFR4,RAF1,PIP4K2B,FGF7,FGF8,ARPC1B,MYL7,MYLK2,DIAPH3,PIK3CA,RDX,ITGA2,TIAM1,ITGA1,WASL,MAP2K1,IQGAP3,MYL12A,EZR,SCIN,MRAS,FN1,PIP5K1A,PIP4K2A,MYLK3,CRK,MYLK,SSH2,FGFR3,SSH3,ITGA9,ITGB1,MAPK1,GIT1,FGF19,SOS2,MYLK4,PXN,MYL5,PAK2,ITGA3,CDC42,FGF2,BCAR1,ITGAD,PPP1R12B,FGFR1,ARHGEF4,PDGFB,ARPC2,HRAS,PIK3CB,RAC1,PIK3R2,ACTG1,FGF17,PIK3R3,CHRM5,CHRM4,BDKRB1,ITGB7,SPATA13,ITGAM,FGF22,FGF23,ARPC4,LIMK2,PFN2,ENAH,ITGA8,PPP1CB,F2,PIP5K1C,MYH14,ACTB,GNA13,FGF10,IQGAP1,KRAS,ITGAX,PIK3CD,CYFIP1,FGF14,PPP1R12A,RHOA,FGF1,FGF18,BRAF,PFN4,VCL,ARPC5,PIKFYVE,MYL2,ABI2,ITGAL,ITGAE,EGF,DOCK1,RAC3,PIP5K1B,PDGFRB,PTK2,INS,ITGB3,MAPK3,INSRR,BDKRB2,PAK6,ARHGEF7,MYL10,PDGFC,CHRM3,ITGA7,NRAS,PIP4K2C,CYFIP2,PFN1,GSN,MYH9,GNA12,ARPC5L,FGF5,GNG12,MAP2K2
hsa04015	Rap1 signaling pathway	0.0135945361966142	-4.29808731721234	210	195	0.030952380952381	6300	7161	5906,8817,1946,84612,2776,375189,6300,673,135,1902,1432,2771,91860,64411,2324,9863,5331,3683,9771,3845,1268,5293,23683,207,2259,54518,3937,387,2246,3480,56034,7423,7422,4893,5216,23094,23566,1944,2321,805,9223,2250,7010,5605,57568,284,1500,1950,5159,3815,5881,810,3690,2904,3630,5584,808,5595,4803,5028,10235,4254,2903,5155,5582,10411,5291,3265,5296,5879,11069,4804,8822,8503,71,7424,107,9965,1436,2773,5578,5587,2247,998,5332,9564,1943,1942,2260,5898,9732,5217,51196,5899,2255,60,5579,196883,26037,5600,5608,115,3791,109,1969,136,3684,5590,27006,7057,3082,8074,2264,5894,2253,5228,2252,5606,83660,80310,2257,6714,3689,111,1499,208,51806,22808,7408,57121,10000,1398,25780,3479,51378,2261,5594,3688,5290,163688,7074,5604,114,5335,10636,3674,801,999,84552,83593,2533,5880,1813,23236,5909,4301,1956,26291,6494,4233,112,5603,7410,2256,2249,9693,5154,56288,260425,3643,2357,2251,2248,285,2149,6237,108,1435,2889,345456,25865,889,5295,51735,113,2778,2770,26281,2254,5330,27040,2263,5156,5908,5900	RAP1A,FGF18,EFNA5,PARD6B,GNAQ,PFN4,MAPK12,BRAF,ADORA2A,LPAR1,MAPK14,GNAI2,CALML4,ARAP3,FLT4,MAGI2,PLCB3,ITGAL,RAPGEF5,KRAS,CNR1,PIK3CD,PRKD3,AKT1,FGF14,APBB1IP,LCP2,RHOA,FGF1,IGF1R,PDGFC,VEGFB,VEGFA,NRAS,PFN1,SIPA1L3,LPAR3,EFNA3,FLT1,CALM2,MAGI1,FGF5,TEK,MAP2K2,SIPA1L2,ANGPT1,CTNND1,EGF,PDGFRB,KIT,RAC3,CALML3,ITGB3,GRIN2B,INS,PRKCI,CALM3,MAPK3,NGF,P2RY1,RASGRP2,KITLG,GRIN2A,PDGFB,PRKCG,RAPGEF3,PIK3CB,HRAS,PIK3R2,RAC1,RAPGEF4,NGFR,FGF17,PIK3R3,ACTG1,VEGFC,ADCY1,FGF19,CSF1R,GNAI3,PRKCA,PRKD1,FGF2,CDC42,PLCB4,BCAR1,EFNA2,EFNA1,FGFR1,RALA,DOCK4,PFN2,PLCE1,RALB,FGF10,ACTB,PRKCB,ADCY4,SIPA1L1,MAPK11,MAP2K6,ADCY9,KDR,ADCY3,EPHA2,ADORA2B,ITGAM,PRKCZ,FGF22,THBS1,HGF,FGF23,FGFR4,RAF1,FGF8,PGF,FGF7,MAP2K3,TLN2,PDGFD,FGF12,SRC,ITGB2,ADCY5,CTNNB1,AKT2,CALML5,MRAS,VASP,LPAR5,AKT3,CRK,RASGRP3,IGF1,ANGPT4,FGFR3,MAPK1,ITGB1,PIK3CA,CALML6,TIAM1,MAP2K1,ADCY8,PLCG1,RGS14,ITGA2B,CALM1,CDH1,PARD6G,RASSF5,FYB1,RAC2,DRD2,PLCB1,RAP1GAP,AFDN,EGFR,FGF21,SIPA1,MET,ADCY6,MAPK13,VAV2,FGF11,FGF4,RAPGEF2,PDGFA,PARD3,MAGI3,INSR,FPR1,FGF6,FGF3,ANGPT2,F2R,RRAS,ADCY2,CSF1,RAPGEF1,PFN3,PRKD2,KRIT1,PIK3R1,RAPGEF6,ADCY7,GNAS,GNAI1,FGF20,FGF9,PLCB2,LAT,FGFR2,PDGFRA,RAP1B,RALGDS
ko04015	Rap1 signaling pathway	0.0135945361966142	-4.29808731721234	210	195	0.030952380952381	6300	7161	5590,3684,136,27006,8074,3082,7057,115,3791,109,1969,5899,2255,5579,60,5600,5608,196883,26037,9732,5217,51196,2773,5578,2247,5587,998,5332,9564,1942,1943,2260,5898,7424,107,9965,1436,5879,5296,4804,11069,71,8822,8503,5582,2903,5155,10411,3265,5291,5595,5028,4803,10235,4254,1500,1950,5159,5881,810,3815,2904,5584,3630,3690,808,1944,2321,805,9223,2250,7010,5605,57568,284,3480,56034,7422,7423,4893,23094,23566,5216,2259,207,54518,3937,387,2246,3845,9771,5293,1268,23683,1432,135,1902,91860,2771,64411,2324,9863,3683,5331,8817,1946,5906,84612,375189,2776,673,6300,2778,26281,2770,2254,27040,5330,2263,5908,5900,5156,25865,889,5295,51735,113,108,6237,1435,2889,345456,2248,285,2149,56288,260425,3643,2251,2357,7410,2256,2249,9693,5154,4301,5909,6494,1956,26291,112,4233,5603,3674,801,999,84552,2533,83593,23236,1813,5880,5604,114,5335,10636,5290,7074,163688,1398,25780,51378,3479,2261,3688,5594,208,51806,7408,22808,10000,57121,6714,111,3689,1499,5606,83660,80310,2257,5894,2264,2252,5228,2253	PRKCZ,ITGAM,ADORA2B,FGF22,FGF23,HGF,THBS1,ADCY9,KDR,ADCY3,EPHA2,RALB,FGF10,PRKCB,ACTB,MAPK11,MAP2K6,ADCY4,SIPA1L1,DOCK4,PFN2,PLCE1,GNAI3,PRKCA,FGF2,PRKD1,CDC42,PLCB4,BCAR1,EFNA1,EFNA2,FGFR1,RALA,VEGFC,ADCY1,FGF19,CSF1R,RAC1,PIK3R2,NGFR,RAPGEF4,ACTG1,FGF17,PIK3R3,PRKCG,GRIN2A,PDGFB,RAPGEF3,HRAS,PIK3CB,MAPK3,P2RY1,NGF,RASGRP2,KITLG,CTNND1,EGF,PDGFRB,RAC3,CALML3,KIT,GRIN2B,PRKCI,INS,ITGB3,CALM3,EFNA3,FLT1,CALM2,MAGI1,FGF5,TEK,MAP2K2,SIPA1L2,ANGPT1,IGF1R,PDGFC,VEGFA,VEGFB,NRAS,SIPA1L3,LPAR3,PFN1,FGF14,AKT1,APBB1IP,LCP2,RHOA,FGF1,KRAS,RAPGEF5,PIK3CD,CNR1,PRKD3,MAPK14,ADORA2A,LPAR1,CALML4,GNAI2,ARAP3,FLT4,MAGI2,ITGAL,PLCB3,FGF18,EFNA5,RAP1A,PARD6B,PFN4,GNAQ,BRAF,MAPK12,GNAS,FGF20,GNAI1,FGF9,LAT,PLCB2,FGFR2,RAP1B,RALGDS,PDGFRA,PRKD2,KRIT1,PIK3R1,RAPGEF6,ADCY7,ADCY2,RRAS,CSF1,RAPGEF1,PFN3,FGF3,ANGPT2,F2R,PARD3,MAGI3,INSR,FGF6,FPR1,VAV2,FGF11,FGF4,RAPGEF2,PDGFA,AFDN,RAP1GAP,SIPA1,EGFR,FGF21,ADCY6,MET,MAPK13,ITGA2B,CALM1,CDH1,PARD6G,FYB1,RASSF5,PLCB1,DRD2,RAC2,MAP2K1,ADCY8,PLCG1,RGS14,PIK3CA,TIAM1,CALML6,CRK,RASGRP3,ANGPT4,IGF1,FGFR3,ITGB1,MAPK1,AKT2,CALML5,VASP,MRAS,AKT3,LPAR5,SRC,ADCY5,ITGB2,CTNNB1,MAP2K3,TLN2,PDGFD,FGF12,RAF1,FGFR4,FGF7,PGF,FGF8
ko04213	Longevity regulating pathway - multiple species	0.0156027253502543	-4.16030967804587	62	60	0.00952380952380952	6300	7161	5293,3310,6199,107,3845,53632,3643,81570,6648,207,51422,111,3306,5564,3265,1410,5291,2475,5565,5568,8660,9474,112,3066,8503,57521,2309,5296,5290,5295,23411,3630,3312,113,5567,115,3065,3304,109,5566,847,2308,114,3667,6647,10000,4893,3305,84335,3480,208,1979,3170,6198,3479,5562,5563,196883,108,5571	PIK3CD,HSPA6,RPS6KB2,ADCY1,KRAS,PRKAG3,INSR,CLPB,SOD2,AKT1,PRKAG2,ADCY5,HSPA2,PRKAB1,HRAS,CRYAB,PIK3CB,MTOR,PRKAB2,PRKACG,IRS2,ATG5,ADCY6,HDAC2,PIK3R3,RPTOR,FOXO3,PIK3R2,PIK3CA,PIK3R1,SIRT1,INS,HSPA8,ADCY7,PRKACB,ADCY9,HDAC1,HSPA1B,ADCY3,PRKACA,CAT,FOXO1,ADCY8,IRS1,SOD1,AKT3,NRAS,HSPA1L,AKT1S1,IGF1R,AKT2,EIF4EBP2,FOXA2,RPS6KB1,IGF1,PRKAA1,PRKAA2,ADCY4,ADCY2,PRKAG1
hsa04213	Longevity regulating pathway - multiple species	0.0156027253502543	-4.16030967804587	62	60	0.00952380952380952	6300	7161	112,9474,3066,8503,57521,5565,5568,8660,5296,2309,3265,1410,5291,2475,81570,6648,3643,53632,3306,111,5564,207,51422,3310,6199,5293,107,3845,196883,3479,5562,5563,108,5571,6647,10000,3305,84335,4893,6198,208,3480,1979,3170,2308,114,3667,3630,3312,5567,113,5290,5295,23411,3304,109,5566,847,115,3065	ADCY6,ATG5,HDAC2,PIK3R3,RPTOR,PRKAB2,PRKACG,IRS2,PIK3R2,FOXO3,HRAS,CRYAB,PIK3CB,MTOR,CLPB,SOD2,INSR,PRKAG3,HSPA2,ADCY5,PRKAB1,AKT1,PRKAG2,HSPA6,RPS6KB2,PIK3CD,ADCY1,KRAS,ADCY4,IGF1,PRKAA1,PRKAA2,ADCY2,PRKAG1,SOD1,AKT3,HSPA1L,AKT1S1,NRAS,RPS6KB1,AKT2,IGF1R,EIF4EBP2,FOXA2,FOXO1,ADCY8,IRS1,INS,HSPA8,PRKACB,ADCY7,PIK3CA,PIK3R1,SIRT1,HSPA1B,ADCY3,PRKACA,CAT,ADCY9,HDAC1
hsa05231	Choline metabolism in cancer	0.0157119740065495	-4.1533321817407	99	94	0.0149206349206349	6300	7161	8527,100137049,5295,6581,3725,5338,5900,5156,126969,255189,6198,8611,283748,23396,57153,5579,10810,10434,6584,6655,9162,5154,6199,5578,60482,6667,5582,5155,23446,1606,160851,6654,10163,2353,5880,3265,5337,5291,5879,5296,6009,1956,5599,5602,8503,1950,5881,5290,8612,8613,8395,5159,80736,3091,5321,8976,8526,5604,5595,1608,5335,123745,7248,56034,208,8394,6582,4893,6583,10000,8605,5170,56994,5605,5594,3845,5293,80310,1978,8936,2885,207,56261,204962,5601,2475,1607,6580,5130,8525,7249,5894,1119,1609	DGKD,PLA2G4B,PIK3R1,SLC22A3,JUN,PLD2,RALGDS,PDGFRA,SLC44A3,PLA2G4F,RPS6KB1,PLPP1,PLA2G4D,PIP5K1C,SLC44A2,PRKCB,WASF3,LYPLA1,SLC22A5,SOS2,DGKI,PDGFA,RPS6KB2,PRKCA,SLC5A7,SP1,PRKCG,PDGFB,SLC44A1,DGKA,DGKH,SOS1,WASF2,FOS,RAC2,HRAS,PLD1,PIK3CB,RAC1,PIK3R2,RHEB,EGFR,MAPK8,MAPK10,PIK3R3,EGF,RAC3,PIK3CA,PLPP2,PLPP3,PIP5K1B,PDGFRB,SLC44A4,HIF1A,PLA2G4A,WASL,DGKE,MAP2K1,MAPK3,DGKG,PLCG1,PLA2G4E,TSC1,PDGFC,AKT2,PIP5K1A,SLC22A2,NRAS,SLC22A4,AKT3,PLA2G4C,PDPK1,CHPT1,MAP2K2,MAPK1,KRAS,PIK3CD,PDGFD,EIF4EBP1,WASF1,GRB2,AKT1,GPCPD1,SLC44A5,MAPK9,MTOR,DGKB,SLC22A1,PCYT1A,DGKZ,TSC2,RAF1,CHKA,DGKQ
ko05231	Choline metabolism in cancer	0.0157119740065495	-4.1533321817407	99	94	0.0149206349206349	6300	7161	5594,5605,56994,6583,6582,4893,10000,8605,5170,56034,208,8394,5335,7248,123745,5604,5595,1608,5881,8613,5159,8395,8612,5290,80736,5321,8976,8526,3091,1950,1609,8525,5894,7249,1119,6580,5130,1607,2475,204962,5601,2885,207,56261,5293,1978,80310,8936,3845,5579,283748,23396,57153,8611,255189,6198,5338,5156,5900,126969,3725,5295,6581,8527,100137049,1956,5599,6009,5602,8503,5296,5879,10163,6654,160851,1606,2353,5880,5291,5337,3265,5155,5582,23446,5578,60482,6667,9162,5154,6199,10810,10434,6584,6655	MAPK1,MAP2K2,CHPT1,SLC22A4,SLC22A2,NRAS,AKT3,PLA2G4C,PDPK1,PDGFC,AKT2,PIP5K1A,PLCG1,TSC1,PLA2G4E,MAP2K1,MAPK3,DGKG,RAC3,PLPP3,PDGFRB,PIP5K1B,PLPP2,PIK3CA,SLC44A4,PLA2G4A,WASL,DGKE,HIF1A,EGF,DGKQ,DGKZ,RAF1,TSC2,CHKA,SLC22A1,PCYT1A,DGKB,MTOR,SLC44A5,MAPK9,GRB2,AKT1,GPCPD1,PIK3CD,EIF4EBP1,PDGFD,WASF1,KRAS,PRKCB,PLA2G4D,PIP5K1C,SLC44A2,PLPP1,PLA2G4F,RPS6KB1,PLD2,PDGFRA,RALGDS,SLC44A3,JUN,PIK3R1,SLC22A3,DGKD,PLA2G4B,EGFR,MAPK8,RHEB,MAPK10,PIK3R3,PIK3R2,RAC1,WASF2,SOS1,DGKH,DGKA,FOS,RAC2,PIK3CB,PLD1,HRAS,PDGFB,PRKCG,SLC44A1,PRKCA,SLC5A7,SP1,DGKI,PDGFA,RPS6KB2,WASF3,LYPLA1,SLC22A5,SOS2
ko04261	Adrenergic signaling in cardiomyocytes	0.0157857214637761	-4.1486494523609	144	135	0.0214285714285714	6300	7161	5294,9254,146850,55012,5522,5523,5500,7170,4635,108,6331,5516,196883,5600,109,784,491,5566,1385,7139,115,148327,113,5529,146,5350,5527,2778,2770,4634,5330,801,154,5528,5520,10411,23236,5502,23533,4624,70,5499,84699,1386,112,5603,3784,11069,481,786,476,107,4625,10369,6548,781,5515,776,486,2773,5578,59283,816,5332,27091,51806,5519,208,779,478,483,775,3753,10000,59285,64764,185,6546,1390,805,5594,147,815,5521,818,7168,596,90993,1388,808,5567,163688,59284,810,5595,6332,10368,488,783,480,785,5526,114,93589,5525,490,2776,6300,27092,7169,6262,817,1432,2771,91860,4633,153,5331,5568,10488,7134,55799,148,468,7171,5501,5518,9252,111,482,6330,9586,207,477,493	PIK3CG,CACNA2D2,PIK3R6,PPP2R3C,PPP2R2C,PPP2R3A,PPP1CB,TPM3,MYL4,ADCY2,SCN5A,PPP2CB,ADCY4,MAPK11,ADCY3,CACNB3,ATP2B2,PRKACA,CREB1,TNNT2,ADCY9,CREB3L4,ADCY7,PPP2R5E,ADRA1D,PLN,PPP2R5C,GNAS,GNAI1,MYL3,PLCB2,CALM1,ADRB2,PPP2R5D,PPP2R2A,RAPGEF3,PLCB1,PPP1R1A,PIK3R5,MYH6,ACTC1,PPP1CA,CREB3L3,ATF2,ADCY6,MAPK13,KCNQ1,RAPGEF4,ATP1B1,CACNG1,ATP1A1,ADCY1,MYH7,CACNG2,SLC9A1,CACNA2D1,PPP2CA,CACNA1D,FXYD2,GNAI3,PRKCA,CACNG8,CAMK2B,PLCB4,CACNG5,CALML5,PPP2R1B,AKT2,CACNA1S,ATP1A3,ATP1B3,CACNA1C,KCNE1,AKT3,CACNG6,CREB3L2,AGTR1,SLC8A1,CREM,CALM2,MAPK1,ADRA1B,CAMK2A,PPP2R2B,CAMK2G,TPM1,BCL2,CREB3L1,ATF6B,CALM3,PRKACB,CALML6,CACNG7,CALML3,MAPK3,SCN7A,CACNG3,ATP2A2,CACNB2,ATP1A4,CACNB4,PPP2R5B,ADCY8,CACNA2D4,PPP2R5A,ATP2B1,GNAQ,MAPK12,CACNG4,TPM2,RYR2,CAMK2D,MAPK14,GNAI2,CALML4,MYL2,ADRB1,PLCB3,PRKACG,CREB3,TNNC1,CACNA2D3,ADRA1A,ATF4,TPM4,PPP1CC,PPP2R1A,RPS6KA5,ADCY5,ATP1B2,SCN4B,CREB5,AKT1,ATP1A2,ATP2B4
hsa04261	Adrenergic signaling in cardiomyocytes	0.0157857214637761	-4.1486494523609	144	135	0.0214285714285714	6300	7161	786,476,481,11069,112,1386,5603,3784,84699,5499,70,4624,23533,5502,23236,5528,5520,10411,801,154,5332,27091,816,2773,5578,59283,486,776,781,5515,10369,6548,107,4625,5600,196883,108,6331,4635,5516,7170,5500,5523,55012,5522,9254,146850,5294,4634,5330,2778,2770,5527,5350,146,5529,148327,113,7139,115,1385,784,109,5566,491,5568,10488,5331,153,817,1432,4633,91860,2771,7169,6262,2776,27092,6300,5525,490,93589,493,207,6330,9586,482,477,111,5518,5501,9252,148,7171,468,7134,55799,815,147,5594,6546,185,805,1390,64764,59285,10000,3753,775,208,5519,483,478,779,51806,114,480,5526,785,6332,488,10368,783,5595,810,59284,5567,163688,808,596,7168,1388,90993,818,5521	CACNG1,ATP1A1,ATP1B1,RAPGEF4,ADCY6,ATF2,MAPK13,KCNQ1,CREB3L3,PPP1CA,ACTC1,MYH6,PIK3R5,PPP1R1A,PLCB1,PPP2R5D,PPP2R2A,RAPGEF3,CALM1,ADRB2,PLCB4,CACNG5,CAMK2B,GNAI3,PRKCA,CACNG8,FXYD2,CACNA1D,CACNA2D1,PPP2CA,CACNG2,SLC9A1,ADCY1,MYH7,MAPK11,ADCY4,ADCY2,SCN5A,MYL4,PPP2CB,TPM3,PPP1CB,PPP2R3A,PPP2R3C,PPP2R2C,CACNA2D2,PIK3R6,PIK3CG,MYL3,PLCB2,GNAS,GNAI1,PPP2R5C,PLN,ADRA1D,PPP2R5E,CREB3L4,ADCY7,TNNT2,ADCY9,CREB1,CACNB3,ADCY3,PRKACA,ATP2B2,PRKACG,CREB3,PLCB3,ADRB1,CAMK2D,MAPK14,MYL2,CALML4,GNAI2,TPM2,RYR2,GNAQ,CACNG4,MAPK12,PPP2R5A,ATP2B1,CACNA2D4,ATP2B4,AKT1,SCN4B,CREB5,ATP1B2,ATP1A2,ADCY5,PPP2R1A,PPP1CC,RPS6KA5,ADRA1A,TPM4,ATF4,TNNC1,CACNA2D3,CAMK2A,ADRA1B,MAPK1,SLC8A1,AGTR1,CALM2,CREM,CREB3L2,CACNG6,AKT3,KCNE1,CACNA1C,AKT2,PPP2R1B,ATP1B3,ATP1A3,CACNA1S,CALML5,ADCY8,ATP1A4,PPP2R5B,CACNB4,SCN7A,ATP2A2,CACNG3,CACNB2,MAPK3,CALML3,CACNG7,PRKACB,CALML6,CALM3,BCL2,TPM1,ATF6B,CREB3L1,CAMK2G,PPP2R2B
ko04340	Hedgehog signaling pathway	0.0177662571823674	-4.03045428464082	47	46	0.0073015873015873	6300	7161	1455,132884,374654,8405,157,8454,4036,339745,2736,408,2737,8945,11127,409,156,23432,122011,1454,5567,2619,91653,5566,50846,596,1453,1452,5568,6608,894,5727,57154,53944,595,23291,3549,2932,51684,50937,6469,2735,64750,2121,8643,1456,8452,64399	CSNK1G2,EVC2,KIF7,SPOP,GRK3,CUL1,LRP2,SPOPL,GLI2,ARRB1,GLI3,BTRC,KIF3A,ARRB2,GRK2,GPR161,CSNK1A1L,CSNK1E,PRKACB,GAS1,BOC,PRKACA,DHH,BCL2,CSNK1D,CSNK1A1,PRKACG,SMO,CCND2,PTCH1,SMURF1,CSNK1G1,CCND1,FBXW11,IHH,GSK3B,SUFU,CDON,SHH,GLI1,SMURF2,EVC,PTCH2,CSNK1G3,CUL3,HHIP
hsa04961	Endocrine and other factor-regulated calcium reabsorption	0.0177662571823674	-4.03045428464082	47	46	0.0073015873015873	6300	7161	5332,160,5578,477,482,486,8218,1173,5568,481,476,5745,5331,9365,3817,112,1785,3816,26052,56302,8766,23236,793,2776,490,5582,163,5330,624,1211,480,2778,5567,7421,115,5566,1175,161,5579,1213,1212,2099,6546,1759,483,478	PLCB4,AP2A1,PRKCA,ATP1A2,ATP1B2,FXYD2,CLTCL1,AP2M1,PRKACG,ATP1B1,ATP1A1,PTH1R,PLCB3,KL,KLK2,ADCY6,DNM2,KLK1,DNM3,TRPV5,RAB11A,PLCB1,CALB1,GNAQ,ATP2B1,PRKCG,AP2B1,PLCB2,BDKRB2,CLTA,ATP1A4,GNAS,PRKACB,VDR,ADCY9,PRKACA,AP2S1,AP2A2,PRKCB,CLTC,CLTB,ESR1,SLC8A1,DNM1,ATP1B3,ATP1A3
ko04961	Endocrine and other factor-regulated calcium reabsorption	0.0177662571823674	-4.03045428464082	47	46	0.0073015873015873	6300	7161	1785,3816,5331,9365,3817,112,5568,481,476,5745,490,163,5582,23236,2776,793,26052,56302,8766,5578,477,482,160,5332,1173,8218,486,2099,6546,161,5579,1213,1212,478,1759,483,2778,624,1211,480,5330,5566,1175,115,5567,7421	DNM2,KLK1,PLCB3,KL,KLK2,ADCY6,PRKACG,ATP1B1,ATP1A1,PTH1R,ATP2B1,AP2B1,PRKCG,PLCB1,GNAQ,CALB1,DNM3,TRPV5,RAB11A,PRKCA,ATP1A2,ATP1B2,AP2A1,PLCB4,AP2M1,CLTCL1,FXYD2,ESR1,SLC8A1,AP2A2,PRKCB,CLTC,CLTB,ATP1A3,DNM1,ATP1B3,GNAS,BDKRB2,CLTA,ATP1A4,PLCB2,PRKACA,AP2S1,ADCY9,PRKACB,VDR
hsa04340	Hedgehog signaling pathway	0.0177662571823674	-4.03045428464082	47	46	0.0073015873015873	6300	7161	51684,50937,2932,2735,6469,64750,64399,8452,8643,1456,2121,1453,1452,5568,6608,53944,57154,5727,894,3549,23291,595,23432,409,156,1454,122011,91653,2619,5567,50846,596,5566,132884,1455,157,8405,374654,408,339745,2736,8454,4036,11127,2737,8945	SUFU,CDON,GSK3B,GLI1,SHH,SMURF2,HHIP,CUL3,PTCH2,CSNK1G3,EVC,CSNK1D,CSNK1A1,PRKACG,SMO,CSNK1G1,SMURF1,PTCH1,CCND2,IHH,FBXW11,CCND1,GPR161,ARRB2,GRK2,CSNK1E,CSNK1A1L,BOC,GAS1,PRKACB,DHH,BCL2,PRKACA,EVC2,CSNK1G2,GRK3,SPOP,KIF7,ARRB1,SPOPL,GLI2,CUL1,LRP2,KIF3A,GLI3,BTRC
ko04370	VEGF signaling pathway	0.0210373774904956	-3.86145454286919	59	57	0.00904761904761905	6300	7161	4846,3791,100137049,5295,5290,9047,9261,5881,5321,5747,5604,25759,5595,5530,5535,123745,5335,208,255189,7422,10000,4893,8605,283748,842,5743,5579,5594,5605,5600,5534,56848,7867,5829,3845,5293,3315,5533,6714,207,5532,5578,998,4773,5582,5336,5291,3265,5880,6300,5894,1432,5296,5879,8877,8503,5603	NOS3,KDR,PLA2G4B,PIK3R1,PIK3CA,SH2D2A,MAPKAPK2,RAC3,PLA2G4A,PTK2,MAP2K1,SHC2,MAPK3,PPP3CA,PPP3R2,PLA2G4E,PLCG1,AKT2,PLA2G4F,VEGFA,AKT3,NRAS,PLA2G4C,PLA2G4D,CASP9,PTGS2,PRKCB,MAPK1,MAP2K2,MAPK11,PPP3R1,SPHK2,MAPKAPK3,PXN,KRAS,PIK3CD,HSPB1,PPP3CC,SRC,AKT1,PPP3CB,PRKCA,CDC42,NFATC2,PRKCG,PLCG2,PIK3CB,HRAS,RAC2,MAPK12,RAF1,MAPK14,PIK3R2,RAC1,SPHK1,PIK3R3,MAPK13
hsa04370	VEGF signaling pathway	0.0210373774904956	-3.86145454286919	59	57	0.00904761904761905	6300	7161	8605,7422,10000,4893,208,255189,5534,5600,5594,5605,56848,5579,5743,842,283748,5321,5747,5290,5295,5881,9047,9261,100137049,3791,4846,123745,5335,5535,5530,5604,5595,25759,3265,5291,5880,6300,5336,5582,8503,5603,8877,1432,5879,5296,5894,3315,5293,5829,7867,3845,4773,998,207,5532,6714,5533,5578	PLA2G4C,VEGFA,AKT3,NRAS,AKT2,PLA2G4F,PPP3R1,MAPK11,MAPK1,MAP2K2,SPHK2,PRKCB,PTGS2,CASP9,PLA2G4D,PLA2G4A,PTK2,PIK3CA,PIK3R1,RAC3,SH2D2A,MAPKAPK2,PLA2G4B,KDR,NOS3,PLA2G4E,PLCG1,PPP3R2,PPP3CA,MAP2K1,MAPK3,SHC2,HRAS,PIK3CB,RAC2,MAPK12,PLCG2,PRKCG,PIK3R3,MAPK13,SPHK1,MAPK14,RAC1,PIK3R2,RAF1,HSPB1,PIK3CD,PXN,MAPKAPK3,KRAS,NFATC2,CDC42,AKT1,PPP3CB,SRC,PPP3CC,PRKCA
hsa04530	Tight junction	0.0233557770719498	-3.75691091339361	170	158	0.0250793650793651	6300	7161	23513,11149,5518,5581,4628,4620,91862,153562,4637,10686,387,9080,912,1365,5601,9475,51422,5111,6714,154810,3993,84612,81,9073,103910,8531,4218,5906,9368,84790,8735,1019,150084,5568,57530,4633,1364,57644,55114,7074,5567,5584,8976,23370,5962,4622,5521,861,2064,137075,64398,10627,7430,54566,910,4217,11346,83700,4629,1739,913,3308,26285,8189,7408,1366,51807,5519,909,100132463,3688,51208,5562,5563,51762,5571,9223,79778,2626,7846,4627,9071,7278,9693,140465,8777,4214,776,5515,22989,644672,112714,10207,10376,5872,7122,50848,53632,998,5564,100506658,9076,5609,93643,56288,1740,3996,53842,57180,87,84552,51421,10097,595,9414,84952,5520,10096,1080,5602,71,4771,58494,149461,5599,5565,2017,4734,4301,5879,911,3059,6794,51735,5566,4619,49861,10398,653857,23327,27134,5590,7082,3725,24146,123720,4621,5522,23562,5010,79784,60,4626,7277,5516,79861,9181,58538	SCRIB,BVES,PPP2R1A,PRKCE,MYH10,MYH2,MARVELD3,MARVELD2,MYL6,CLDN16,RHOA,CLDN9,CD1D,CLDN3,MAPK9,ROCK2,PRKAG2,PCNA,SRC,AMOTL1,LLGL2,PARD6B,ACTN4,CLDN8,MYL12B,YBX3,RAB8A,RAP1A,NHERF1,TUBA1C,MYH13,CDK4,IGSF5,PRKACG,CGN,MYL2,CLDN4,MYH7B,ARHGAP17,TIAM1,PRKACB,PRKCI,WASL,ARHGEF18,RDX,MYH4,PPP2R2B,RUNX1,ERBB2,CLDN23,PALS1,MYL12A,EZR,EPB41L4B,CD1B,MAP3K5,SYNPO,JAM3,MYH11,DLG1,CD1E,HSPA4,CLDN17,SYMPK,VASP,CLDN7,TUBA8,PPP2R1B,CD1A,CLDN24,ITGB1,CLDN18,PRKAA1,PRKAA2,RAB8B,PRKAG1,MAGI1,MICALL2,GATA4,TUBA1A,MYH9,CLDN10,TUBA3C,RAPGEF2,MYL6B,MPDZ,MAP3K1,CACNA1D,PPP2CA,MYH15,CLDN25,TUBA3E,PATJ,TUBA1B,RAB13,CLDN5,F11R,PRKAG3,CDC42,PRKAB1,OCLN,CLDN1,MAP2K7,TJAP1,PARD3,DLG2,LLGL1,CLDN22,ACTR3B,ACTN1,PARD6G,AMOTL2,ACTR2,CCND1,TJP2,CGNL1,PPP2R2A,ACTR3,CFTR,MAPK10,ACTG1,NF2,JAM2,CLDN19,MAPK8,PRKAB2,CTTN,NEDD4,AFDN,RAC1,CD1C,HCLS1,STK11,RAPGEF6,PRKACA,MYH1,CLDN20,MYL9,ACTR3C,NEDD4L,TJP3,PRKCZ,TJP1,JUN,CLDN15,WHAMM,MYH3,PPP2R2C,CLDN14,CLDN11,MYH14,ACTB,MYH8,TUBA4A,PPP2CB,TUBAL3,ARHGEF2,MPP4
ko04530	Tight junction	0.0233557770719498	-3.75691091339361	170	158	0.0250793650793651	6300	7161	58538,9181,79861,5516,4626,7277,79784,60,5010,23562,123720,4621,5522,24146,5590,3725,7082,27134,23327,653857,10398,4619,5566,49861,51735,6794,3059,911,5879,4301,2017,4734,5565,149461,5599,71,4771,58494,1080,5602,5520,10096,595,51421,10097,84952,9414,87,84552,57180,53842,1740,3996,93643,56288,100506658,9076,5609,998,5564,53632,7122,50848,5872,10376,10207,644672,112714,776,22989,5515,8777,4214,9693,140465,9071,7278,7846,4627,79778,2626,9223,5571,51762,5562,5563,3688,51208,100132463,909,5519,51807,7408,8189,1366,26285,913,3308,4629,1739,83700,4217,11346,54566,910,7430,10627,2064,64398,137075,861,4622,5521,5962,23370,5584,8976,5567,7074,55114,4633,57644,1364,57530,5568,84790,8735,9368,1019,150084,5906,4218,8531,103910,81,84612,9073,3993,154810,6714,9475,51422,5111,912,1365,5601,387,9080,10686,4637,153562,91862,5581,4628,4620,5518,11149,23513	MPP4,ARHGEF2,TUBAL3,PPP2CB,MYH8,TUBA4A,MYH14,ACTB,CLDN11,CLDN14,WHAMM,MYH3,PPP2R2C,CLDN15,PRKCZ,JUN,TJP1,TJP3,NEDD4L,ACTR3C,MYL9,MYH1,PRKACA,CLDN20,RAPGEF6,STK11,HCLS1,CD1C,RAC1,AFDN,CTTN,NEDD4,PRKAB2,CLDN19,MAPK8,ACTG1,NF2,JAM2,CFTR,MAPK10,PPP2R2A,ACTR3,CCND1,AMOTL2,ACTR2,CGNL1,TJP2,ACTN1,PARD6G,ACTR3B,CLDN22,DLG2,LLGL1,TJAP1,PARD3,OCLN,CLDN1,MAP2K7,CDC42,PRKAB1,PRKAG3,CLDN5,F11R,RAB13,TUBA1B,PATJ,CLDN25,TUBA3E,CACNA1D,MYH15,PPP2CA,MPDZ,MAP3K1,RAPGEF2,MYL6B,CLDN10,TUBA3C,TUBA1A,MYH9,MICALL2,GATA4,MAGI1,PRKAG1,RAB8B,PRKAA1,PRKAA2,ITGB1,CLDN18,CLDN24,CD1A,PPP2R1B,TUBA8,VASP,SYMPK,CLDN7,CLDN17,CD1E,HSPA4,MYH11,DLG1,JAM3,MAP3K5,SYNPO,EPB41L4B,CD1B,EZR,MYL12A,ERBB2,PALS1,CLDN23,RUNX1,MYH4,PPP2R2B,RDX,ARHGEF18,PRKCI,WASL,PRKACB,TIAM1,ARHGAP17,MYL2,MYH7B,CLDN4,CGN,PRKACG,TUBA1C,MYH13,NHERF1,CDK4,IGSF5,RAP1A,RAB8A,YBX3,MYL12B,ACTN4,PARD6B,CLDN8,LLGL2,AMOTL1,SRC,ROCK2,PRKAG2,PCNA,CD1D,CLDN3,MAPK9,RHOA,CLDN9,CLDN16,MYL6,MARVELD2,MARVELD3,PRKCE,MYH10,MYH2,PPP2R1A,BVES,SCRIB
ko04210	Apoptosis	0.0238965702429632	-3.73402033482095	138	129	0.0204761904761905	6300	7161	5551,9451,8795,143,84790,6709,5894,1509,1965,4914,472,330,1515,355,7185,153090,5601,4790,3708,1439,8794,823,8717,207,100506742,5293,1520,581,10039,468,1514,3845,5594,5605,7846,7124,10018,3709,4893,8743,10000,836,5170,332,51807,208,1147,6708,4792,9020,1677,841,5604,5595,4217,55367,4616,4803,4001,1522,54205,5290,1616,142,1075,596,1508,5599,27429,840,5602,84823,63970,8772,8503,71,5296,3551,56616,5414,2353,317,4000,5291,27113,3265,5970,598,1647,835,7278,329,8722,2021,839,10376,10912,843,824,112714,8837,60,3710,7277,8793,356,79861,3562,842,597,7132,1521,1513,1512,4170,5783,3725,10038,7157,3002,578,1676,8739,8737,8797,5295,1519,5366,2081	PRF1,EIF2AK3,TNFRSF10B,PARP4,TUBA1C,SPTAN1,RAF1,CTSD,EIF2S1,NTRK1,ATM,BIRC3,CTSV,FAS,TRAF1,DAB2IP,MAPK9,NFKB1,ITPR1,CSF2RB,TNFRSF10C,CAPN1,TRADD,AKT1,CASP12,PIK3CD,CTSS,BAX,PARP3,ATF4,CTSL,KRAS,MAPK1,MAP2K2,TUBA1A,TNF,BCL2L11,ITPR2,NRAS,TNFSF10,AKT3,CASP3,PDPK1,BIRC5,TUBA8,AKT2,CHUK,SPTA1,NFKBIA,MAP3K14,DFFB,CASP8,MAP2K1,MAPK3,MAP3K5,PIDD1,GADD45B,NGF,LMNB1,CTSZ,CYCS,PIK3CA,DAXX,PARP1,CTSC,BCL2,CTSB,MAPK8,HTRA2,CASP7,MAPK10,LMNB2,TP53AIP1,FADD,PIK3R3,ACTG1,PIK3R2,IKBKB,DIABLO,SEPTIN4,FOS,APAF1,LMNA,PIK3CB,BBC3,HRAS,RELA,BCL2L1,GADD45A,CASP2,TUBA3C,BIRC2,CTSF,ENDOG,CASP6,TUBA1B,GADD45G,CASP10,CAPN2,TUBA3E,CFLAR,ACTB,ITPR3,TUBA4A,TNFRSF10D,FASLG,TUBAL3,IL3,CASP9,BCL2A1,TNFRSF1A,CTSW,CTSK,CTSH,MCL1,PTPN13,JUN,PARP2,TP53,GZMB,BAK1,DFFA,HRK,RIPK1,TNFRSF10A,PIK3R1,CTSO,PMAIP1,ERN1
hsa04210	Apoptosis	0.0238965702429632	-3.73402033482095	138	129	0.0204761904761905	6300	7161	2081,5366,1519,5295,8797,8737,5783,4170,578,1676,8739,3002,7157,10038,3725,1521,7132,597,1512,1513,356,8793,7277,3710,8837,60,3562,842,79861,2021,329,8722,835,7278,1647,112714,824,843,10912,10376,839,598,27113,3265,5291,4000,317,2353,5414,5970,71,8503,8772,84823,63970,5602,840,27429,5599,56616,3551,5296,1075,1616,142,5290,54205,1522,4001,1508,596,841,1677,9020,6708,4792,4803,4616,4217,55367,5604,5595,5170,332,836,10000,8743,4893,1147,208,51807,5594,5605,10018,3709,7124,7846,1514,581,10039,468,1520,5293,3845,1439,3708,4790,153090,5601,7185,355,100506742,823,207,8717,8794,1509,1515,330,472,1965,4914,84790,143,8795,9451,5551,5894,6709	ERN1,PMAIP1,CTSO,PIK3R1,TNFRSF10A,RIPK1,PTPN13,MCL1,BAK1,DFFA,HRK,GZMB,TP53,PARP2,JUN,CTSW,TNFRSF1A,BCL2A1,CTSH,CTSK,FASLG,TNFRSF10D,TUBA4A,ITPR3,CFLAR,ACTB,IL3,CASP9,TUBAL3,ENDOG,BIRC2,CTSF,CASP2,TUBA3C,GADD45A,TUBA3E,CAPN2,CASP10,GADD45G,TUBA1B,CASP6,BCL2L1,BBC3,HRAS,PIK3CB,LMNA,APAF1,FOS,SEPTIN4,RELA,ACTG1,PIK3R3,FADD,LMNB2,TP53AIP1,MAPK10,CASP7,HTRA2,MAPK8,DIABLO,IKBKB,PIK3R2,CTSC,DAXX,PARP1,PIK3CA,CYCS,CTSZ,LMNB1,CTSB,BCL2,CASP8,DFFB,MAP3K14,SPTA1,NFKBIA,NGF,GADD45B,MAP3K5,PIDD1,MAP2K1,MAPK3,PDPK1,BIRC5,CASP3,AKT3,TNFSF10,NRAS,CHUK,AKT2,TUBA8,MAPK1,MAP2K2,BCL2L11,ITPR2,TNF,TUBA1A,CTSL,BAX,PARP3,ATF4,CTSS,PIK3CD,KRAS,CSF2RB,ITPR1,NFKB1,DAB2IP,MAPK9,TRAF1,FAS,CASP12,CAPN1,AKT1,TRADD,TNFRSF10C,CTSD,CTSV,BIRC3,ATM,EIF2S1,NTRK1,TUBA1C,PARP4,TNFRSF10B,EIF2AK3,PRF1,RAF1,SPTAN1
hsa04662	B cell receptor signaling pathway	0.0244232270670743	-3.71222067050159	70	67	0.0106349206349206	6300	7161	3635,5881,5290,5295,10451,1380,4793,4792,4775,6850,5535,3725,5595,5604,5530,2213,4893,10000,973,975,1147,208,974,5534,5594,5605,5579,25780,8519,7409,4067,5293,3845,6655,27071,7410,2932,933,4772,4773,84433,4790,118788,5777,2885,5532,207,5533,5880,3265,5291,6654,8915,2353,5336,930,5970,8503,10892,29760,5879,4794,5296,3551,971,3636,5894	INPP5D,RAC3,PIK3CA,PIK3R1,VAV3,CR2,NFKBIB,NFKBIA,NFATC3,SYK,PPP3R2,JUN,MAPK3,MAP2K1,PPP3CA,FCGR2B,NRAS,AKT3,CD79A,CD81,CHUK,AKT2,CD79B,PPP3R1,MAPK1,MAP2K2,PRKCB,RASGRP3,IFITM1,VAV1,LYN,PIK3CD,KRAS,SOS2,DAPP1,VAV2,GSK3B,CD22,NFATC1,NFATC2,CARD11,NFKB1,PIK3AP1,PTPN6,GRB2,PPP3CB,AKT1,PPP3CC,RAC2,HRAS,PIK3CB,SOS1,BCL10,FOS,PLCG2,CD19,RELA,PIK3R3,MALT1,BLNK,RAC1,NFKBIE,PIK3R2,IKBKB,CD72,INPPL1,RAF1
ko04662	B cell receptor signaling pathway	0.0244232270670743	-3.71222067050159	70	67	0.0106349206349206	6300	7161	5535,5595,5530,5604,3725,4775,6850,4793,4792,1380,10451,5290,5295,5881,3635,8519,25780,5579,5534,5594,5605,974,208,975,1147,10000,973,4893,2213,5532,207,5533,2885,4790,84433,5777,118788,4772,4773,933,2932,7410,27071,6655,3845,5293,4067,7409,5894,971,3636,3551,5879,5296,4794,29760,8503,10892,5970,930,5336,8915,2353,6654,3265,5291,5880	PPP3R2,MAPK3,PPP3CA,MAP2K1,JUN,NFATC3,SYK,NFKBIB,NFKBIA,CR2,VAV3,PIK3CA,PIK3R1,RAC3,INPP5D,IFITM1,RASGRP3,PRKCB,PPP3R1,MAPK1,MAP2K2,CD79B,AKT2,CD81,CHUK,AKT3,CD79A,NRAS,FCGR2B,PPP3CB,AKT1,PPP3CC,GRB2,NFKB1,CARD11,PTPN6,PIK3AP1,NFATC1,NFATC2,CD22,GSK3B,VAV2,DAPP1,SOS2,KRAS,PIK3CD,LYN,VAV1,RAF1,CD72,INPPL1,IKBKB,RAC1,PIK3R2,NFKBIE,BLNK,PIK3R3,MALT1,RELA,CD19,PLCG2,BCL10,FOS,SOS1,HRAS,PIK3CB,RAC2
ko00630	Glyoxylate and dicarboxylate metabolism	0.0274872246049658	-3.59403394207038	28	28	0.00444444444444444	6300	7161	1431,275,6470,6472,5096,4190,2752,283871,847,1738,38,112817,4594,84693,125061,50,2653,2731,132158,39,51179,189,4191,48,54363,5095,9380,81888	CS,AMT,SHMT1,SHMT2,PCCB,MDH1,GLUL,PGP,CAT,DLD,ACAT1,HOGA1,MMUT,MCEE,AFMID,ACO2,GCSH,GLDC,GLYCTK,ACAT2,HAO2,AGXT,MDH2,ACO1,HAO1,PCCA,GRHPR,HYI
hsa00630	Glyoxylate and dicarboxylate metabolism	0.0274872246049658	-3.59403394207038	28	28	0.00444444444444444	6300	7161	6472,6470,275,1431,2752,4190,5096,38,1738,283871,847,125061,84693,4594,112817,2731,2653,50,48,4191,51179,189,132158,39,5095,9380,54363,81888	SHMT2,SHMT1,AMT,CS,GLUL,MDH1,PCCB,ACAT1,DLD,PGP,CAT,AFMID,MCEE,MMUT,HOGA1,GLDC,GCSH,ACO2,ACO1,MDH2,HAO2,AGXT,GLYCTK,ACAT2,PCCA,GRHPR,HAO1,HYI
hsa01100	Metabolic pathways	0.0296907648132723	-3.51691923057623	1256	1125	0.178571428571429	6300	7161	54,10715,384,10622,4718,4860,89869,204,262,8527,5226,30833,5427,54577,114805,978,1743,1371,280,10690,51056,93432,2538,9380,339221,2629,129607,8897,8802,60495,84245,686,10026,471,2346,2628,440567,54578,3293,245973,4190,250,5333,8309,7306,5432,2582,8692,51763,56052,10965,9615,4719,2744,57104,10728,201595,151056,5441,57733,113612,117248,10588,29906,8877,256435,2687,2678,3704,5446,7368,8659,54205,6999,56953,246,4715,126,34,2222,126328,8513,11232,4837,414328,84920,9197,204219,4522,4720,515,3707,80055,6482,26330,5223,6184,29785,64409,178,374378,51301,23530,1373,23205,100861540,4329,84649,411,5424,7054,4697,11181,126792,54802,1040,27090,2805,6390,84720,66008,8813,83440,3155,51733,4507,1716,2180,10558,54363,23057,5336,64425,8050,5331,5214,56267,1788,7365,1585,95,5091,7384,3340,92579,8702,10400,138429,127281,242,5096,79053,5430,253430,5558,55312,113451,1594,3613,127,247,5837,9588,270,29926,221,8789,5859,3948,84803,2650,4548,514,6241,11283,4704,317749,55301,337876,144193,5162,8564,56901,539,2135,6476,4122,10157,290,249,224,1543,2218,2593,84620,125981,3145,10449,1588,2571,11041,5238,1577,36,6307,6609,205,6392,10243,4707,635,120227,6898,3990,15,84284,64132,7263,210,137964,3945,314,2954,1036,346606,5860,3162,2591,23382,93183,523,158,130,63826,1339,4907,11320,4247,9486,51102,7378,8974,8867,113675,2058,4722,1589,1607,18,6480,162466,26290,7915,594,259230,5834,2821,200895,122618,10873,644,51004,8833,221264,10632,53,100137049,23646,5049,169355,7083,64131,5538,55512,5980,2271,275,148789,1635,4245,8644,2590,7385,952,10993,51196,1584,1595,646625,1355,84076,8803,10714,51380,79603,6448,7991,29954,51816,51251,53354,3292,4351,128,5332,248,5723,2992,5433,2583,1491,55703,8693,80142,2937,5557,7173,23545,4705,622,81579,2134,2653,140838,5048,284004,501,4709,33,5313,339896,152586,54575,6309,383,1579,203,51540,8801,197258,7923,6470,1608,1638,84532,4248,7086,10585,2137,6483,9663,79369,6888,83539,54187,2548,251,29958,189,1056,3081,55361,23743,8869,22845,525,4249,1337,7389,84002,80201,55748,5406,10768,374291,57678,353,2651,84274,6240,10020,5805,64600,4708,25885,5431,23498,2581,9942,3628,1609,5625,159,1152,11227,8372,79623,64900,8703,3290,54965,166929,2181,570,8529,5330,3157,10195,5498,2990,729920,9550,10901,27124,3612,57134,80270,26,8608,2572,23475,131,255189,2720,9110,90423,6713,1621,283358,1806,284716,84647,4695,84706,6391,2235,112817,199857,125061,8898,211,5286,192134,64419,10,348158,661,3705,5281,9533,132789,5105,391013,2026,549,4726,7108,593,3631,23175,54344,2592,239,5428,10201,4144,3425,8879,8639,7166,54928,50700,51606,2632,341392,79799,56624,4717,3283,5440,10229,9348,29920,10423,54579,7498,1644,27165,6185,8540,10905,56922,3938,130013,8605,128869,51703,4714,513,1345,548596,84892,4191,8706,93034,79888,4698,51109,3163,3633,55304,6916,4121,271,55568,441024,220,79695,1503,4048,3939,23761,3034,7364,79586,790,6472,11145,326625,2023,9,2643,4723,5161,22978,9536,8942,2762,5283,3909,223,253782,8525,27034,26229,221830,284098,5051,154141,4831,4710,27349,10855,5372,27087,32,226,4725,5322,2645,55326,2530,654364,3706,9377,51809,9388,5444,2746,132158,4842,3417,10135,84812,10402,4199,873,4696,64768,516,29796,57494,2683,8708,54981,85007,574537,535,1431,170712,587,1854,6120,5224,65263,2997,1717,3030,5169,55276,3906,5337,11019,23007,125,84265,3712,56898,2194,6718,1610,7360,8612,54659,8526,56655,9791,56894,79646,57818,7372,52,81849,3703,54995,2132,7358,11112,9114,10720,23553,4728,218,4833,5053,3294,79814,29929,55650,124454,5742,5471,3101,5288,245972,6697,10941,51179,64850,253558,1629,9563,1327,5211,5232,2203,1582,8705,316,4729,1557,55500,122970,8821,26275,116285,10975,440,11285,5289,10476,10317,84735,11343,8871,81888,443,2618,29956,151531,221823,145226,10654,55902,5297,55224,6677,528,57704,2686,79611,1723,3067,55750,64802,11226,9060,883,283871,6342,1576,85365,4706,10797,2588,5833,1109,8566,2527,3032,23417,131669,5408,155066,51805,55821,4731,283748,340485,65220,55163,50614,7264,7381,5409,442117,4942,10312,4712,5315,10826,1351,2597,30815,1591,27430,7386,2730,9487,9514,29940,160851,1606,57026,5320,55907,80025,3795,26301,55624,9249,51074,30,25796,22856,5439,2589,28,222,6489,1544,146664,3074,7390,57452,9245,51727,79077,50617,23193,10005,5319,80271,4056,51227,339983,5836,1650,8394,4598,493911,5831,29925,1573,6296,1757,9517,51166,54947,51728,29968,1738,26279,55627,51604,4337,55454,9215,9108,341947,23556,160287,1603,22928,435,56603,1633,8854,5198,55790,119548,517,387787,3614,80146,5740,1593,229,586,124,1353,2524,10329,50,150763,27159,29880,22929,4967,60490,4594,8398,51084,142827,11086,6821,3099,55808,123688,5373,54576,1562,3141,1312,27306,526,8611,1548,9488,1159,100,10170,7371,54490,64902,168391,134147,121278,23396,427,2131,80339,9489,6484,63917,1158,157506,1066,51079,2528,64579,10331,54480,5407,2639,83549,53630,2224,51181,3098,1581,54675,5095,349565,120071,4524,8790,9365,10327,216,5236,31,1586,8613,8395,84890,5321,4846,129642,133686,58478,6487,55967,3911,518,3373,2053,4832,54511,9107,2595,1160,509,4338,874,3422,26035,5743,54107,39,1350,56895,124975,1737,26289,83594,5434,2584,9562,2731,29922,2712,1583,23305,25902,4953,64377,2525,5188,10606,55753,4597,3242,8310,91012,80308,3615,7941,8560,130589,283459,54963,10623,79087,4700,9651,9061,51,48,3620,7084,276,9331,37,79796,162417,54657,1786,5445,6675,50487,7298,10007,9091,283208,51382,4724,123099,5338,279,191,2752,2998,5832,1718,171568,92483,6610,8630,55577,23600,3033,22934,338707,79178,51478,54600,3419,1962,84618,1340,2799,9945,875,51082,135152,27231,2673,81889,8972,1555,127124,7363,8707,84172,3418,2729,9162,246721,2184,51268,55349,506,51144,2987,51601,9453,533,27010,240,54658,548644,272,58510,23236,30814,7299,729020,26007,79717,51477,8992,5167,1719,35,132,81616,5298,6389,7366,84693,4143,669,57804,25834,6652,3295,27235,4124,5335,219,123745,3284,55256,1118,23649,3156,259307,8818,10380,8760,6723,7841,1329,144245,79147,50484,2806,5279,4702,5033,1807,56848,522,231,1558,56994,123876,55300,2531,53947,47,5287,57016,529,122622,38,122481,217,81490,2027,683,1559,55229,11282,728635,4830,445,8704,498,5130,3420,7357,56913,4711,1592,138050,11128,55191,10390,1352,4716,10678,1119,7167	ACP5,CERS1,ARG2,POLR3G,NDUFC2,PNP,PLCZ1,AK2,AMD1,DGKD,PGD,NT5C,POLE2,UGT1A7,GALNT13,CDA,DLST,CPOX,AMY2B,FUT9,LAP3,MGAM2,G6PC1,GRHPR,ENPP7,GBA1,CMPK2,MTMR3,SUCLG1,HPSE2,MRI1,BTD,PIGK,ATIC,FOLH1,GATM,UQCRHL,UGT1A6,HSD17B3,ATP6V1C2,MDH1,ALPP,PLCD1,ACOX2,TYRP1,POLR2C,GALE,HYAL2,INPP5K,ALG1,ACOT2,GDA,NDUFS1,GLS,PNPLA2,PTGES3,STT3B,PLB1,POLR2L,GBA3,CYP2U1,GALNT15,MTHFS,ST8SIA5,SPHK1,ST6GALNAC3,GGT5,GGT1,ITPA,PON3,UGT8,ALDH4A1,CYCS,TDO2,NT5M,ALOX15,NDUFB9,ADH1C,ACADM,FDFT1,NDUFA11,LIPF,POLG2,NNMT,IDNK,ALG10,SLC33A1,CERS3,MTHFD1,NDUFS2,ATP5PB,ITPKB,PGAP1,ST3GAL1,GAPDHS,PGAM1,RPN1,CYP2S1,GALNT17,AGL,GALNT18,GCNT4,NNT,CPS1,ACSBG1,CYP3A7-CYP3A51P,ALDH6A1,DGAT2,ARSB,POLD1,TH,NDUFA4,TREH,B3GALT6,TRIT1,CDS1,ST6GALNAC4,GOT1,SDHB,PIGO,TRAK2,DPM1,ADPGK,HMGCL,UPB1,MTAP,DGUOK,ACSL1,SPTLC1,HAO1,NMNAT2,PLCG2,POLR1E,PDHX,PLCB3,PFKP,KYAT3,DNMT3A,UGT2B10,CYP11B2,ACY1,PC,UQCRC1,NDST1,G6PC3,B4GALT4,PEMT,PIP5KL1,PRXL2B,ALOX12B,PCCB,ALG8,POLR2A,IPMK,PRIM2,RFK,AZIN2,CYP27B1,IMPA2,ADH4,ALOX15B,PYGM,PRDX6,AMPD1,GMPPA,ALDH3B1,FBP2,QARS1,LDHC,GPAT3,GCNT1,MTR,ATP5F1E,RRM2,CYP4F8,NDUFA9,DHRS4L2,OLAH,CHSY3,AMDHD1,PDHB,KMO,NDUFA4L2,ATP5PO,EXTL2,SI,MAN2A2,AASS,ANPEP,ALPL,ALDH3A2,CYP1A1,FKTN,GAMT,ST6GAL2,ACER1,HMBS,ACAA2,CYP19A1,GAD1,B4GAT1,PGM3,CYP3A5,ACADSB,MSMO1,SMPD1,AK4,SDHD,GPHN,NDUFB1,BHMT,CYP2R1,TAT,LIPC,AANAT,NTPCR,XYLT2,TST,ALAD,GPAT4,LDHB,AOC2,GSTZ1,CDO1,MOGAT3,QDPR,HMOX1,GALNT3,AHCYL2,PIGM,ATP6V1A,ADSL,ADH6,SRR,COX6A2,NT5E,MGAT4A,MGAT2,CHST10,MECR,UPP1,P4HA2,SYNJ1,SDSL,EPRS1,NDUFS3,CYP21A2,DGKB,ABAT,ST6GAL1,PHOSPHO1,GALNT8,ALDH5A1,BCKDHB,SGMS1,PYGB,GPI,DHFR2,PLD4,ME3,BLVRA,COQ6,GMPS,AK9,ATP5MG,ACP2,PLA2G4B,PLD3,PAFAH1B2,IDO2,TK1,XYLT1,PPT1,SMPD3,REV3L,FH,AMT,B3GALNT2,DCTD,MGAT1,AKR1C3,GALNT2,UQCRC2,CD38,SDS,PLCE1,CYP11B1,CYP51A1,URAD,COX15,TKTL2,SUCLA2,POLD3,CSAD,CERS4,SGSH,TUSC3,POMT2,ADA2,NT5C3A,PANK1,HSD17B1,MPI,ADH5,PLCB4,ALPI,PSPH,GYG1,POLR2D,B4GALNT1,CTH,POLR3B,GALNT4,PTGES2,GSS,PRIM1,TPO,ATP6V0A2,NDUFA10,BDH1,PLA2G12A,EXTL1,GCSH,NANP,PAFAH1B1,HEXD,ALDH7A1,NDUFB3,ACADL,PKLR,GADL1,MGAT4D,UGT1A10,SC5D,ARG1,CYP4A11,AK1,SCLY,SUCLG2,FCSK,HSD17B8,SHMT1,DGKG,DCT,ACSS1,MGAT3,TKT,POMT1,EXTL3,ST3GAL2,LPIN2,B3GNT4,TALDO1,CHST9,NANS,GAA,ALPG,DMGDH,AGXT,CEL,HGD,PI4K2A,BHMT2,ST3GAL5,DOLK,ATP6V1B1,MGAT5,COX6A1,UROD,B3GNT5,HKDC1,CNDP2,PNLIP,AHCYL1,NDUFS7,GPAM,APRT,GCNT2,COQ5,RRM1,GNE,PTS,PLA2G2F,NDUFB2,POLR1A,POLR2B,HAAO,GALC,XYLB,INPP1,DGKQ,PRODH,ADSS2,CKB,GALNT5,HYAL3,GALNT14,LPIN3,B4GALT3,HSD11B1,PIGX,SGMS2,ACSL3,BAAT,CYP4F2,PLCB2,HMGCS1,ALG3,PPOX,GUSB,CRPPA,ATP6V1G1,DHRS4,INPP5J,IMPA1,MAN1C1,HSD3B7,AOC1,RDH16,GAD2,QPRT,ADH7,PLA2G4F,GLB1,MTMR4,ATP6V1E2,SQLE,DBH,B4GALNT3,DPYD,RIMKLA,PLA2G12B,NDUFA2,GPT2,SDHC,FECH,HOGA1,ALG14,AFMID,MTMR2,ALAS1,PIK3C2A,B3GNT6,MTMR14,NAT2,ACSM2B,POLR3D,ITPK1,PIGF,POLR1C,GNPDA2,PCK1,PLA2G2C,ENO2,AUH,NDUFS6,TM7SF2,BCKDHA,INPP4A,LPIN1,DPM3,GALT,ALOX12,POLG,NME6,MAT2A,IDUA,SGPL1,AOC3,TPH1,BPNT2,RDH8,ATP6V1H,GBE1,ACSM4,UGT2A3,ASAH2,NDUFC1,HSD3B1,POLR2K,COQ7,NDST3,PYCR2,CDIPT,UGT1A5,XDH,DDC,GLS2,RPN2,AGPS,MAN1A2,MCCC1,LCT,ACMSD,PLA2G4C,PIGU,ACSL5,NDUFB8,ATP5F1D,COX6C,CKMT1A,POMGNT2,MDH2,B3GALNT1,NT5C1B,LPCAT1,NDUFA5,RDH11,HMOX2,INPP5B,SPTLC3,TBXAS1,MAN1A1,AMPD2,GALNT10,MTHFD2L,ALDH1A3,GALNT12,CTPS1,LTA4H,LDHA,PISD,HAL,UGT2B7,CHPF,CAD,SHMT2,PLAAT3,MMAB,ENO1,NAT1,GCH1,NDUFV1,PDHA2,NT5C2,PTGES,KYNU,GMDS,PIGH,LAMA3,ALDH9A1,CERS6,DGKZ,ACAD8,B3GAT3,POLR1F,PIGW,PAFAH2,MBOAT1,NME2,NDUFB4,MCAT,HPSE,PMM1,B3GAT1,ACACB,ALDOA,NDUFS5,PLA2G5,GCK,AGPAT5,FUT8,NME1-NME2,ITPKA,COX5A,GALNT7,LIPG,PON1,GLUD1,GLYCTK,NOS1,IDH1,NAMPT,PLCD4,ST3GAL6,ME1,CBR1,NDUFA3,IPPK,ATP5MC1,UQCR10,RIMKLB,B4GALT1,B3GALT1,NMRK1,PHYKPL,UGT2A2,ATP6V0A1,CS,COX7B2,BCAT2,DUT,RPE,PGAM2,PYCR3,GYS1,DHCR7,HADHA,ENPP3,PGM2,LALBA,PLD1,LIAS,PLCH1,ADH1B,POLR3GL,IVD,BDH2,FASN,AKR1D1,DAO,UGP2,PLPP2,UGT1A3,DGKE,POLE4,PTDSS1,AGPAT3,PANK3,G6PC2,UMPS,ACP1,ST6GALNAC5,STT3A,OXSM,EXT2,UGDH,HIBADH,ATP6V0D1,UGT2B11,HYAL4,NDUFS8,ALDH3A1,NME4,PAH,HSD17B2,AGMAT,ALG6,PIGV,EARS2,PTGS1,PPAT,HK3,PIK3C2G,ATP6V0D2,SPR,UGT2A1,HAO2,ETNPPL,LCLAT1,DBT,H6PD,COX4I1,PFKL,PGK2,FBP1,CYP8B1,B3GALT4,AOX1,NDUFV2,CYP2C19,ETNK1,ACOT4,INPP4B,HIBCH,ACSM1,UQCR11,ASNS,B4GALT7,PIK3C3,ATP5PD,B3GALT5,CNDP1,MGLL,SYNJ2,HYI,ASPA,GART,CERS2,UPP2,PRPS1L1,RDH12,PMVK,ACSS2,PI4KA,ETNK2,SPAM1,ATP6V1C1,GBA2,GGT7,ACSS3,DHODH,HDC,AGK,NMNAT1,GALNT6,PAPSS2,KYAT1,PGP,SCP2,CYP3A4,ALG2,NDUFAB1,MTHFD2,GALNS,PCYT2,AKR1C4,PDXK,FUT5,HADHB,MLYCD,UROC1,PNLIPRP2,ATP6V0E2,COQ3,ALLC,NDUFV3,PLA2G4D,ACER2,NADK,PNPO,GALNT9,GFUS,UQCRB,PNMT,GALNTL6,OAT,TCIRG1,NDUFB6,PKM,FAXDC2,COX8A,GAPDH,ST6GALNAC6,CYP24A1,MAT2B,UQCRFS1,GCLM,PIGL,GAL3ST1,DSE,DGKH,DGKA,PDXP,PLA2G2A,CMAS,PANK2,KHK,GBGT1,POMGNT1,DHRS3,APIP,ACAA1,PGLS,CHSY1,POLR2J,GALNT1,ABO,ALDH3B2,ST8SIA1,CYP1A2,MGAT5B,HEXB,UROS,GALNT16,GCNT3,CMPK1,DCTPP1,ATP6V0A4,GANAB,ACOT8,PLA2G1B,ITPKC,LTC4S,PIGP,NAT8L,PYGL,DDOST,PIP5K1A,MVK,PHOSPHO2,PYCR1,GMPPB,CYP2J2,ACSM3,SARDH,SPTLC2,AADAT,LPCAT2,POLR3K,PSAT1,DLD,PLA2G2D,SMPD4,PIGT,MOCS1,CSGALNACT2,LARGE1,MTMR7,COX8C,PIGN,LDHAL6A,DAD1,SEPHS2,ASL,CYP26B1,DCK,ALDH1A2,PFAS,CSGALNACT1,PNLIPRP3,ATP5MC2,LIPT2,IMPDH1,UXS1,PTGIS,CYP27A1,ALDOB,BCAT1,ADH1A,COX11,FUT2,RXYLT1,ACO2,GPAT2,CHIA,ALG5,SEPHS1,OGDH,PPCDC,MMUT,PLA2G6,CRYL1,ACSM6,ADAM29,SUOX,HK2,ST6GALNAC1,HYKK,PMM2,UGT1A8,CYP2C18,HLCS,COMT,HPGDS,ATP6V1B2,PLPP1,CYP2A6,PIGB,CKMT1B,ADA,DHRS9,UCK2,UGT2B28,AGXT2,GALNTL5,CMBL,TPH2,PIP5K1C,ASAH1,EXT1,PNPLA3,PGS1,ST3GAL4,GALNT11,CKM,RDH10,CES1,NDUFA13,FUT6,NDST4,B3GNT3,CHPF2,PNLIPRP1,GCDH,UCK1,BCO1,FDPS,DCXR,HK1,CYP7A1,CRLS1,PCCA,NMNAT3,LARGE2,MTHFR,FPGT,KL,AKR1A1,ALDH1A1,PGM1,ACACA,CYP17A1,PLPP3,PIP5K1B,ADO,PLA2G4A,NOS3,MBOAT2,NADK2,ENOPH1,ST3GAL3,NDUFA12,LAMA5,ATP5MC3,HYAL1,EPHX2,NME3,HMGCLL1,MTMR6,GANC,CKMT2,ATP5F1C,MOCS2,CBR3,IDI1,GLCE,PTGS2,POLE3,ACAT2,COX7C,AGPAT4,GGT6,DLAT,AK5,NUDT12,POLR2E,GALK1,MINPP1,GLDC,NME7,GK2,CYP11A1,ACSL6,MTHFD1L,ODC1,CHST8,FUT3,GATB,PAICS,OGDHL,MVD,HPD,ACOX3,CERS5,FLAD1,IMPDH2,PLA2G7,DEGS1,GALM,GATC,UCKL1,POLR3C,ALG12,NDUFA6,PLCH2,PAPSS1,ACOX1,ACO1,IDO1,TK2,AMY1A,B4GALT6,ACADVL,ALG9,NAGS,UGT1A4,DNMT1,PON2,UAP1,PLA2G3,TYMS,GNPDA1,PIGQ,P4HA3,ATP6V1D,NDUFS4,DEGS2,PLD2,AMY2A,AHCY,GLUL,GYS2,ALDH18A1,DHCR24,POLR3H,LDHAL6B,SMPD2,HSD17B6,NAGK,AMACR,HADH,RPIA,B4GALNT4,THTPA,HSD17B7,UGT1A9,IDH3A,EHHADH,NT5C1A,COX6B1,GNS,GFPT2,CBS,POLR1D,B3GAT2,NMRK2,GFPT1,FAHD1,MGAM,CYP2B6,ATP6V1G3,UGT2B4,B3GALT2,POLR1B,IDH2,GCLC,DGKI,POLR2J2,FAH,PIPOX,CHDH,ATP5F1B,HSD17B12,GUK1,LIPT1,GGPS1,ATP6V0B,TPK1,ALOX5,UGT1A1,POLR2J3,AMPD3,PRODH2,PLCB1,PLA2G2E,TYR,RPEL1,TKFC,PPCS,ISYNA1,ATP6V0E1,ENPP1,DHFR,ACADS,ADK,ACSBG2,PI4KB,SDHA,UGT2B15,MCEE,MAT1A,BPGM,POLD4,MGAT4C,SORD,HSD17B4,COQ2,MAN2A1,PLCG1,ALDH1B1,PLA2G4E,HSD3B2,ADI1,CHIT1,POLA2,HMGCR,IL4I1,DPM2,BPNT1,CDS2,SRM,MOGS,COX5B,ALG10B,FKRP,RRM2B,GOT2,PIGC,NDUFA8,P4HA1,DPYS,SPHK2,ATP5PF,AKR1B1,CYP2C8,CHPT1,ACSM2A,PI4K2B,KDSR,A4GALT,ACLY,PIK3C2B,AKR1B10,ATP6V1E1,ADSS1,ACAT1,AK7,ALDH2,PTDSS2,ENO3,BST1,CYP2C9,PANK4,MGAT4B,DHRS4L1,NME1,ASS1,B4GALT2,ATP5F1A,PCYT1A,IDH3B,UGCG,C1GALT1,NDUFB5,CYP26A1,HGSNAT,POLR3A,NADSYN1,CEPT1,COX10,NDUFB10,B3GNT2,CHKA,TPI1
hsa04110	Cell cycle	0.029904350614975	-3.50975130365284	124	116	0.0184126984126984	6300	7161	896,4616,4998,10274,4175,2033,23594,5934,7529,8555,996,1870,7042,4174,27127,7043,2810,7709,991,9133,891,699,23595,8317,6502,10459,1031,8454,902,5111,5925,8318,7533,7532,64682,9088,1021,5000,1026,9232,8556,7465,994,701,5591,7040,1387,5347,4171,4999,1019,4609,1017,4085,472,6500,51434,894,5885,11200,7157,4087,1874,983,4193,3065,4089,7272,8900,1032,1875,7534,25,51433,5001,1028,8379,10393,1871,29945,1029,4173,4172,545,990,51529,2932,9700,51343,10912,890,1647,1027,898,9134,1030,7531,10926,1869,7029,1111,1022,9184,494551,10744,3066,5933,4088,8697,10971,993,595,7027,995,9978,9126	CCND3,GADD45B,ORC1,STAG1,MCM6,EP300,ORC6,RBL2,YWHAB,CDC14B,CDC27,E2F2,TGFB2,MCM5,SMC1B,TGFB3,SFN,ZBTB17,CDC20,CCNB2,CCNB1,BUB1,ORC3,CDC7,SKP2,MAD2L2,CDKN2C,CUL1,CCNH,PCNA,RB1,CDC45,YWHAH,YWHAG,ANAPC1,PKMYT1,CDK6,ORC4,CDKN1A,PTTG1,CDC14A,WEE1,CDC25B,BUB1B,PRKDC,TGFB1,CREBBP,PLK1,MCM2,ORC2,CDK4,MYC,CDK2,MAD2L1,ATM,SKP1,ANAPC7,CCND2,RAD21,CHEK2,TP53,SMAD2,E2F4,CDK1,MDM2,HDAC1,SMAD4,TTK,CCNA1,CDKN2D,E2F5,YWHAZ,ABL1,ANAPC5,ORC5,CDKN1C,MAD1L1,ANAPC10,E2F3,ANAPC4,CDKN2A,MCM4,MCM3,ATR,CDC6,ANAPC11,GSK3B,ESPL1,FZR1,GADD45G,CCNA2,GADD45A,CDKN1B,CCNE1,CCNE2,CDKN2B,YWHAE,DBF4,E2F1,TFDP2,CHEK1,CDK7,BUB3,WEE2,PTTG2,HDAC2,RBL1,SMAD3,CDC23,YWHAQ,CDC25A,CCND1,TFDP1,CDC25C,RBX1,SMC3
ko04110	Cell cycle	0.029904350614975	-3.50975130365284	124	116	0.0184126984126984	6300	7161	11200,5885,894,472,4085,1017,4609,51434,6500,5347,1019,4999,4171,994,701,7465,8556,1387,7040,5591,1026,9232,5000,1021,9088,8318,5925,902,5111,64682,7532,7533,1031,8454,699,9133,891,6502,8317,10459,23595,2810,991,7709,7043,4174,27127,7042,1870,996,8555,7529,5934,2033,4175,23594,4616,896,4998,10274,995,9126,9978,4088,5933,7027,993,10971,595,8697,1111,7029,3066,10744,494551,9184,1022,7531,1869,10926,898,1027,1647,9134,1030,10912,51343,890,990,545,4172,4173,9700,2932,51529,1871,1029,29945,8379,10393,51433,25,7534,1028,5001,1875,4089,8900,7272,1032,3065,4193,1874,983,7157,4087	CHEK2,RAD21,CCND2,ATM,MAD2L1,CDK2,MYC,ANAPC7,SKP1,PLK1,CDK4,ORC2,MCM2,CDC25B,BUB1B,WEE1,CDC14A,CREBBP,TGFB1,PRKDC,CDKN1A,PTTG1,ORC4,CDK6,PKMYT1,CDC45,RB1,CCNH,PCNA,ANAPC1,YWHAG,YWHAH,CDKN2C,CUL1,BUB1,CCNB2,CCNB1,SKP2,CDC7,MAD2L2,ORC3,SFN,CDC20,ZBTB17,TGFB3,MCM5,SMC1B,TGFB2,E2F2,CDC27,CDC14B,YWHAB,RBL2,EP300,MCM6,ORC6,GADD45B,CCND3,ORC1,STAG1,CDC25C,SMC3,RBX1,SMAD3,RBL1,TFDP1,CDC25A,YWHAQ,CCND1,CDC23,CHEK1,TFDP2,HDAC2,PTTG2,WEE2,BUB3,CDK7,YWHAE,E2F1,DBF4,CCNE1,CDKN1B,GADD45A,CCNE2,CDKN2B,GADD45G,FZR1,CCNA2,CDC6,ATR,MCM3,MCM4,ESPL1,GSK3B,ANAPC11,E2F3,CDKN2A,ANAPC4,MAD1L1,ANAPC10,ANAPC5,ABL1,YWHAZ,CDKN1C,ORC5,E2F5,SMAD4,CCNA1,TTK,CDKN2D,HDAC1,MDM2,E2F4,CDK1,TP53,SMAD2
hsa04660	T cell receptor signaling pathway	0.0303948440232292	-3.49348228945347	102	96	0.0152380952380952	6300	7161	5534,5605,5594,4690,7124,5170,1739,10000,919,4893,1147,915,208,3702,3458,56924,9020,5335,8440,4793,4792,3558,5535,5595,5604,5290,2534,1019,10892,1493,1432,3565,920,5894,29851,3932,6300,917,5058,84433,4790,3937,5601,4772,387,4773,207,2885,7409,5293,3845,57144,1437,5600,1326,10125,6885,926,5588,4775,27040,867,7535,3725,5530,5295,10451,3567,8503,5603,3551,5296,10298,4794,3265,5291,9402,8915,2353,6654,868,940,5970,2932,5788,5777,5609,998,5532,5533,23624,3586,5062,6655,916,7410	PPP3R1,MAP2K2,MAPK1,NCK1,TNF,PDPK1,DLG1,AKT3,CD247,NRAS,CHUK,CD3D,AKT2,ITK,IFNG,PAK6,MAP3K14,PLCG1,NCK2,NFKBIB,NFKBIA,IL2,PPP3R2,MAPK3,MAP2K1,PIK3CA,FYN,CDK4,MALT1,CTLA4,MAPK14,IL4,CD4,RAF1,ICOS,LCK,MAPK12,CD3G,PAK1,CARD11,NFKB1,LCP2,MAPK9,NFATC1,RHOA,NFATC2,AKT1,GRB2,VAV1,PIK3CD,KRAS,PAK5,CSF2,MAPK11,MAP3K8,RASGRP1,MAP3K7,CD8B,PRKCQ,NFATC3,LAT,CBL,ZAP70,JUN,PPP3CA,PIK3R1,VAV3,IL5,PIK3R3,MAPK13,IKBKB,PIK3R2,PAK4,NFKBIE,HRAS,PIK3CB,GRAP2,BCL10,FOS,SOS1,CBLB,CD28,RELA,GSK3B,PTPRC,PTPN6,MAP2K7,CDC42,PPP3CB,PPP3CC,CBLC,IL10,PAK2,SOS2,CD3E,VAV2
ko04660	T cell receptor signaling pathway	0.0303948440232292	-3.49348228945347	102	96	0.0152380952380952	6300	7161	2932,5788,5777,5609,998,5532,5533,23624,3586,5062,6655,916,7410,8503,5603,3551,4794,5296,10298,3265,5291,9402,8915,2353,6654,868,940,5970,4775,27040,867,7535,3725,5530,5295,10451,3567,5600,1326,10125,6885,926,5588,3937,84433,4790,5601,4772,387,4773,207,2885,7409,5293,3845,57144,1437,10892,1019,1493,1432,3565,920,5894,29851,3932,6300,5058,917,3702,56924,3458,9020,8440,5335,4793,4792,3558,5535,5595,5604,5290,2534,5534,5605,5594,4690,7124,5170,1739,10000,919,4893,1147,915,208	GSK3B,PTPRC,PTPN6,MAP2K7,CDC42,PPP3CB,PPP3CC,CBLC,IL10,PAK2,SOS2,CD3E,VAV2,PIK3R3,MAPK13,IKBKB,NFKBIE,PIK3R2,PAK4,HRAS,PIK3CB,GRAP2,BCL10,FOS,SOS1,CBLB,CD28,RELA,NFATC3,LAT,CBL,ZAP70,JUN,PPP3CA,PIK3R1,VAV3,IL5,MAPK11,MAP3K8,RASGRP1,MAP3K7,CD8B,PRKCQ,LCP2,CARD11,NFKB1,MAPK9,NFATC1,RHOA,NFATC2,AKT1,GRB2,VAV1,PIK3CD,KRAS,PAK5,CSF2,MALT1,CDK4,CTLA4,MAPK14,IL4,CD4,RAF1,ICOS,LCK,MAPK12,PAK1,CD3G,ITK,PAK6,IFNG,MAP3K14,NCK2,PLCG1,NFKBIB,NFKBIA,IL2,PPP3R2,MAPK3,MAP2K1,PIK3CA,FYN,PPP3R1,MAP2K2,MAPK1,NCK1,TNF,PDPK1,DLG1,AKT3,CD247,NRAS,CHUK,CD3D,AKT2
hsa05134	Legionellosis	0.031132079129039	-3.46951650816142	55	53	0.00841269841269841	6300	7161	29108,5970,4615,2920,317,1378,1937,840,1195,7415,81876,3310,929,3606,51128,3689,7100,3306,834,1915,3553,5861,3592,3593,4790,375,1917,3576,2919,3305,836,7124,56681,842,4791,9554,3304,3329,10767,3312,2921,54205,7099,7097,664,58484,3684,4671,718,3569,23786,841,4792	PYCARD,RELA,MYD88,CXCL2,APAF1,CR1,EEF1G,CASP7,CLK1,VCP,RAB1B,HSPA6,CD14,IL18,SAR1B,ITGB2,TLR5,HSPA2,CASP1,EEF1A1,IL1B,RAB1A,IL12A,IL12B,NFKB1,ARF1,EEF1A2,CXCL8,CXCL1,HSPA1L,CASP3,TNF,SAR1A,CASP9,NFKB2,SEC22B,HSPA1B,HSPD1,HBS1L,HSPA8,CXCL3,CYCS,TLR4,TLR2,BNIP3,NLRC4,ITGAM,NAIP,C3,IL6,BCL2L13,CASP8,NFKBIA
ko05134	Legionellosis	0.031132079129039	-3.46951650816142	55	53	0.00841269841269841	6300	7161	3569,23786,841,4792,7097,58484,664,3684,718,4671,10767,3329,3312,2921,7099,54205,3304,9554,4791,56681,7124,842,2919,3305,836,375,1917,3576,3593,3592,4790,51128,834,3306,7100,3689,3553,1915,5861,929,3310,3606,1195,7415,81876,1937,840,1378,2920,4615,317,29108,5970	IL6,BCL2L13,CASP8,NFKBIA,TLR2,NLRC4,BNIP3,ITGAM,C3,NAIP,HBS1L,HSPD1,HSPA8,CXCL3,TLR4,CYCS,HSPA1B,SEC22B,NFKB2,SAR1A,TNF,CASP9,CXCL1,HSPA1L,CASP3,ARF1,EEF1A2,CXCL8,IL12B,IL12A,NFKB1,SAR1B,CASP1,HSPA2,TLR5,ITGB2,IL1B,EEF1A1,RAB1A,CD14,HSPA6,IL18,CLK1,VCP,RAB1B,EEF1G,CASP7,CR1,CXCL2,MYD88,APAF1,PYCARD,RELA
hsa04950	Maturity onset diabetes of the young	0.035549882672648	-3.33681842308579	26	26	0.00412698412698413	6300	7161	5313,3171,2494,3174,3630,168620,3375,389692,5080,6928,4825,3172,3170,3175,3651,50674,5078,2645,6514,6927,3087,222546,4760,3280,3110,4821	PKLR,FOXA3,NR5A2,HNF4G,INS,BHLHA15,IAPP,MAFA,PAX6,HNF1B,NKX6-1,HNF4A,FOXA2,ONECUT1,PDX1,NEUROG3,PAX4,GCK,SLC2A2,HNF1A,HHEX,RFX6,NEUROD1,HES1,MNX1,NKX2-2
ko04950	Maturity onset diabetes of the young	0.035549882672648	-3.33681842308579	26	26	0.00412698412698413	6300	7161	3174,3630,2494,3171,5313,6928,4825,389692,3375,5080,168620,6514,3087,6927,2645,3651,5078,50674,3172,3175,3170,4821,3110,3280,222546,4760	HNF4G,INS,NR5A2,FOXA3,PKLR,HNF1B,NKX6-1,MAFA,IAPP,PAX6,BHLHA15,SLC2A2,HHEX,HNF1A,GCK,PDX1,PAX4,NEUROG3,HNF4A,ONECUT1,FOXA2,NKX2-2,MNX1,HES1,RFX6,NEUROD1
hsa04068	FoxO signaling pathway	0.0356349223304877	-3.3344291576157	132	123	0.0195238095238095	6300	7161	5564,10365,1901,3586,5105,6648,3575,23710,53632,3643,6655,10912,114907,1030,10733,6774,1027,1647,9140,5296,6517,3551,2309,5603,5602,8503,5599,1956,901,11337,5565,595,4088,3265,5291,26260,6654,4087,1454,664,3667,8698,3569,5728,2308,4193,847,92579,116986,11345,1032,10769,6794,23411,5295,4089,7046,7874,5600,356,2911,2538,5897,2885,51422,207,5601,3845,1026,5293,7040,7048,1432,1387,5894,604,6789,8660,5347,1017,9456,472,673,894,6300,5604,5595,4616,9455,80854,23678,57818,2033,1950,5934,3630,5290,1263,5571,10018,7043,2290,7042,9454,5594,6446,5605,5562,5563,3276,3479,6502,1147,9133,891,208,3480,5896,5170,4893,10110,10000,8743	PRKAB1,KLF2,S1PR1,IL10,PCK1,SOD2,IL7R,GABARAPL1,PRKAG3,INSR,SOS2,GADD45G,FBXO32,CDKN2B,PLK4,STAT3,CDKN1B,GADD45A,ATG12,PIK3R2,SLC2A4,IKBKB,FOXO3,MAPK13,MAPK10,PIK3R3,MAPK8,EGFR,CCNG2,GABARAP,PRKAB2,CCND1,SMAD3,HRAS,PIK3CB,FBXO25,SOS1,SMAD2,CSNK1E,BNIP3,IRS1,S1PR4,IL6,PTEN,FOXO1,MDM2,CAT,G6PC3,AGAP2,GABARAPL2,CDKN2D,PLK2,STK11,SIRT1,PIK3R1,SMAD4,TGFBR1,USP7,MAPK11,FASLG,GRM1,G6PC1,RAG2,GRB2,PRKAG2,AKT1,MAPK9,KRAS,CDKN1A,PIK3CD,TGFB1,TGFBR2,MAPK14,CREBBP,RAF1,BCL6,STK4,IRS2,PLK1,CDK2,HOMER1,ATM,BRAF,CCND2,MAPK12,MAP2K1,MAPK3,GADD45B,HOMER2,SETD7,SGK3,G6PC2,EP300,EGF,RBL2,INS,PIK3CA,PLK3,PRKAG1,BCL2L11,TGFB3,FOXG1,TGFB2,HOMER3,MAPK1,SGK1,MAP2K2,PRKAA1,PRKAA2,PRMT1,IGF1,SKP2,CHUK,CCNB2,CCNB1,AKT2,IGF1R,RAG1,PDPK1,NRAS,SGK2,AKT3,TNFSF10
ko04933	AGE-RAGE signaling pathway in diabetic complications	0.0379621957864448	-3.27116446217034	99	93	0.0147619047619048	6300	7161	4846,596,1958,5290,7056,5595,6777,1285,5335,2152,208,6772,2335,4893,10000,7422,836,7423,185,7124,7043,7042,1284,5594,5581,3845,5293,5292,50508,581,177,3553,3552,207,4772,4790,5601,1729,3383,5336,1286,6300,7040,7048,1432,1281,5331,1019,7412,4089,5295,7046,6401,5590,3725,1277,4087,6776,5330,2308,3569,3576,5580,51196,84812,6347,4313,5579,5600,5054,7424,6774,1027,1906,3717,5578,1282,998,5332,5333,4088,5970,1278,595,23236,3265,5291,5879,5296,5599,5603,5602,8503	NOS3,BCL2,EGR1,PIK3CA,THBD,MAPK3,STAT5B,COL4A3,PLCG1,F3,AKT2,STAT1,FN1,NRAS,AKT3,VEGFA,CASP3,VEGFB,AGTR1,TNF,TGFB3,TGFB2,COL4A2,MAPK1,PRKCE,KRAS,PIK3CD,PIM1,NOX3,BAX,AGER,IL1B,IL1A,AKT1,NFATC1,NFKB1,MAPK9,DIAPH1,ICAM1,PLCG2,COL4A4,MAPK12,TGFB1,TGFBR2,MAPK14,COL3A1,PLCB3,CDK4,VCAM1,SMAD4,PIK3R1,TGFBR1,SELE,PRKCZ,JUN,COL1A1,SMAD2,STAT5A,PLCB2,FOXO1,IL6,CXCL8,PRKCD,PLCE1,PLCD4,CCL2,MMP2,PRKCB,MAPK11,SERPINE1,VEGFC,STAT3,CDKN1B,EDN1,JAK2,PRKCA,COL4A1,CDC42,PLCB4,PLCD1,SMAD3,RELA,COL1A2,CCND1,PLCB1,HRAS,PIK3CB,RAC1,PIK3R2,MAPK8,MAPK13,MAPK10,PIK3R3
hsa04933	AGE-RAGE signaling pathway in diabetic complications	0.0379621957864448	-3.27116446217034	99	93	0.0147619047619048	6300	7161	5333,5332,5578,1282,998,1906,6774,1027,3717,5054,7424,5599,8503,5602,5603,5296,5879,5291,3265,23236,5970,1278,4088,595,2308,5330,6776,3569,3725,5590,1277,4087,4089,5295,7046,6401,7412,5579,5600,6347,84812,4313,5580,3576,51196,5601,4790,4772,1729,207,3552,3553,50508,5292,5293,177,581,3845,5581,1019,5331,1281,1432,7040,7048,1286,6300,5336,3383,5335,2152,1285,6777,5595,7056,5290,596,4846,1958,5594,1284,185,7042,7043,7124,7423,836,10000,7422,4893,208,2335,6772	PLCD1,PLCB4,PRKCA,COL4A1,CDC42,EDN1,STAT3,CDKN1B,JAK2,SERPINE1,VEGFC,MAPK8,PIK3R3,MAPK10,MAPK13,PIK3R2,RAC1,PIK3CB,HRAS,PLCB1,RELA,COL1A2,SMAD3,CCND1,FOXO1,PLCB2,STAT5A,IL6,JUN,PRKCZ,COL1A1,SMAD2,SMAD4,PIK3R1,TGFBR1,SELE,VCAM1,PRKCB,MAPK11,CCL2,PLCD4,MMP2,PRKCD,CXCL8,PLCE1,MAPK9,NFKB1,NFATC1,DIAPH1,AKT1,IL1A,IL1B,NOX3,PIM1,PIK3CD,AGER,BAX,KRAS,PRKCE,CDK4,PLCB3,COL3A1,MAPK14,TGFB1,TGFBR2,COL4A4,MAPK12,PLCG2,ICAM1,PLCG1,F3,COL4A3,STAT5B,MAPK3,THBD,PIK3CA,BCL2,NOS3,EGR1,MAPK1,COL4A2,AGTR1,TGFB2,TGFB3,TNF,VEGFB,CASP3,AKT3,VEGFA,NRAS,AKT2,FN1,STAT1
ko04152	AMPK signaling pathway	0.0392504231464982	-3.23779305400933	120	112	0.0177777777777778	6300	7161	5209,6720,51422,207,9586,10890,148,5293,5518,2203,23216,1978,200186,29904,5214,8660,10488,5862,5468,7249,10645,4218,2475,3952,3953,5525,5526,57818,7248,3156,81617,3630,51552,5290,1938,5521,90993,5562,5563,3479,55437,64764,5571,5211,5208,51719,5170,84335,10000,79602,208,3480,5519,1374,3643,53632,5564,9370,5210,5105,6199,3991,10891,5515,890,2194,1080,57521,8503,6009,5565,5296,6517,31,84699,2309,5291,2997,948,595,51094,6319,5520,5528,3172,2998,2308,5527,32,3667,8900,148327,23411,6794,5295,5529,126129,1385,92579,5516,8408,2538,23417,6198,1994,6885,8789,5523,92335,55012,5522,79966	PFKFB3,SREBF1,PRKAG2,AKT1,CREB5,RAB10,ADRA1A,PIK3CD,PPP2R1A,FBP1,TBC1D1,EIF4EBP1,CRTC2,EEF2K,PFKP,IRS2,CREB3,RAB2A,PPARG,TSC2,CAMKK2,RAB8A,MTOR,LEP,LEPR,PPP2R5A,PPP2R5B,G6PC2,TSC1,HMGCR,CAB39L,INS,RAB14,PIK3CA,EEF2,PPP2R2B,CREB3L1,PRKAA1,PRKAA2,IGF1,STRADB,CREB3L2,PRKAG1,PFKL,PFKFB2,CAB39,PDPK1,AKT1S1,AKT3,ADIPOR2,AKT2,IGF1R,PPP2R1B,CPT1A,INSR,PRKAG3,PRKAB1,ADIPOQ,PFKFB4,PCK1,RPS6KB2,LIPE,PPARGC1A,PPP2CA,CCNA2,FASN,CFTR,RPTOR,PIK3R3,RHEB,PRKAB2,PIK3R2,SLC2A4,ACACA,CREB3L3,FOXO3,PIK3CB,GYS1,CD36,CCND1,ADIPOR1,SCD,PPP2R2A,PPP2R5D,HNF4A,GYS2,FOXO1,PPP2R5C,ACACB,IRS1,CCNA1,CREB3L4,SIRT1,STK11,PIK3R1,PPP2R5E,CPT1C,CREB1,G6PC3,PPP2CB,ULK1,G6PC1,MLYCD,RPS6KB1,ELAVL1,MAP3K7,FBP2,PPP2R3A,STRADA,PPP2R3C,PPP2R2C,SCD5
hsa04152	AMPK signaling pathway	0.0392504231464982	-3.23779305400933	120	112	0.0177777777777778	6300	7161	51552,5290,1938,81617,3630,90993,5521,57818,7248,5526,3156,84335,10000,5170,208,3480,5519,79602,5562,5563,3479,55437,64764,5571,5208,5211,51719,5293,5518,23216,2203,200186,1978,10890,148,29904,5209,51422,207,9586,6720,10645,2475,3952,5525,3953,4218,8660,10488,5214,7249,5862,5468,23411,6794,5529,5295,148327,8900,126129,92579,1385,2308,2998,3667,32,5527,23417,2538,92335,5523,5522,55012,79966,6198,1994,8789,6885,8408,5516,3991,10891,5515,6199,890,3643,53632,1374,5210,5105,5564,9370,2997,948,5291,6319,3172,5528,5520,595,51094,6009,5565,2194,57521,1080,8503,84699,2309,5296,6517,31	RAB14,PIK3CA,EEF2,CAB39L,INS,CREB3L1,PPP2R2B,G6PC2,TSC1,PPP2R5B,HMGCR,AKT1S1,AKT3,PDPK1,AKT2,IGF1R,PPP2R1B,ADIPOR2,PRKAA1,PRKAA2,IGF1,STRADB,CREB3L2,PRKAG1,PFKFB2,PFKL,CAB39,PIK3CD,PPP2R1A,TBC1D1,FBP1,CRTC2,EIF4EBP1,RAB10,ADRA1A,EEF2K,PFKFB3,PRKAG2,AKT1,CREB5,SREBF1,CAMKK2,MTOR,LEP,PPP2R5A,LEPR,RAB8A,IRS2,CREB3,PFKP,TSC2,RAB2A,PPARG,SIRT1,STK11,PPP2R5E,PIK3R1,CREB3L4,CCNA1,CPT1C,G6PC3,CREB1,FOXO1,GYS2,IRS1,ACACB,PPP2R5C,MLYCD,G6PC1,STRADA,PPP2R3A,PPP2R2C,PPP2R3C,SCD5,RPS6KB1,ELAVL1,FBP2,MAP3K7,ULK1,PPP2CB,LIPE,PPARGC1A,PPP2CA,RPS6KB2,CCNA2,INSR,PRKAG3,CPT1A,PFKFB4,PCK1,PRKAB1,ADIPOQ,GYS1,CD36,PIK3CB,SCD,HNF4A,PPP2R5D,PPP2R2A,CCND1,ADIPOR1,RHEB,PRKAB2,FASN,RPTOR,CFTR,PIK3R3,CREB3L3,FOXO3,PIK3R2,SLC2A4,ACACA
ko04728	Dopaminergic synapse	0.0405687782525134	-3.20475651677199	130	121	0.0192063492063492	6300	7161	3800,6300,2776,3798,6323,5525,10488,10681,2931,5568,5331,406,91860,2771,1432,817,5501,5518,468,2784,7054,94235,5601,9575,3708,1816,207,9586,111,10000,775,1815,773,208,5519,51806,815,2774,55970,84152,805,2791,3709,64764,3765,810,3799,808,163688,5567,51764,2904,1388,1814,90993,2891,818,5521,6570,5526,2786,1644,59345,2353,1812,1813,23236,2788,2890,5528,5582,5520,2903,801,5599,5603,5602,6571,1386,84699,5499,3762,776,3763,5515,5332,2932,816,5578,2790,5532,2773,5533,1312,5500,5523,5522,55012,2783,2893,2782,5579,3710,5600,6531,5516,3760,5529,148327,54331,1385,5566,409,5330,2778,2770,5530,2792,2793,5527,2787	KIF5C,MAPK12,GNAQ,KIF5A,SCN1A,PPP2R5A,CREB3,GNB5,GSK3A,PRKACG,PLCB3,BMAL1,CALML4,GNAI2,MAPK14,CAMK2D,PPP1CC,PPP2R1A,ATF4,GNB3,TH,GNG8,MAPK9,CLOCK,ITPR1,DRD5,AKT1,CREB5,ADCY5,AKT3,CACNA1C,DRD4,CACNA1A,AKT2,PPP2R1B,CALML5,CAMK2A,GNAL,GNG12,PPP1R1B,CALM2,GNG11,ITPR2,CREB3L2,KCNJ9,CALML3,KIF5B,CALM3,CALML6,PRKACB,GNG13,GRIN2B,ATF6B,DRD3,CREB3L1,GRIA2,CAMK2G,PPP2R2B,SLC18A1,PPP2R5B,GNG4,DDC,GNB4,FOS,DRD1,DRD2,PLCB1,GNG7,GRIA1,PPP2R5D,PRKCG,PPP2R2A,GRIN2A,CALM1,MAPK8,MAPK13,MAPK10,SLC18A2,ATF2,CREB3L3,PPP1CA,KCNJ5,CACNA1D,KCNJ6,PPP2CA,PLCB4,GSK3B,CAMK2B,PRKCA,GNG10,PPP3CB,GNAI3,PPP3CC,COMT,PPP1CB,PPP2R3A,PPP2R2C,PPP2R3C,GNB2,GRIA4,GNB1,PRKCB,ITPR3,MAPK11,SLC6A3,PPP2CB,KCNJ3,PPP2R5E,CREB3L4,GNG2,CREB1,PRKACA,ARRB2,PLCB2,GNAS,GNAI1,PPP3CA,GNGT1,GNGT2,PPP2R5C,GNG5
hsa04728	Dopaminergic synapse	0.0405687782525134	-3.20475651677199	130	121	0.0192063492063492	6300	7161	10000,775,1815,773,208,5519,51806,815,55970,2774,84152,805,64764,3709,2791,810,3765,3799,5567,51764,163688,808,2904,1388,1814,90993,2891,818,5521,6570,5526,2786,1644,6300,3800,2776,3798,6323,5525,10488,10681,2931,5568,5331,406,91860,2771,817,1432,5518,5501,468,2784,7054,94235,5601,9575,3708,1816,207,9586,111,1312,5500,5523,55012,5522,2783,2893,2782,5579,3710,5600,6531,5516,3760,5529,148327,54331,1385,5566,409,5330,2778,2770,5530,2792,2793,5527,2787,59345,2353,1812,1813,23236,2788,2890,5528,5520,5582,2903,801,5599,5603,5602,6571,1386,84699,5499,3762,776,3763,5515,5332,2932,816,5578,2790,2773,5532,5533	AKT3,CACNA1C,DRD4,CACNA1A,AKT2,PPP2R1B,CALML5,CAMK2A,GNG12,GNAL,PPP1R1B,CALM2,CREB3L2,ITPR2,GNG11,CALML3,KCNJ9,KIF5B,PRKACB,GNG13,CALML6,CALM3,GRIN2B,ATF6B,DRD3,CREB3L1,GRIA2,CAMK2G,PPP2R2B,SLC18A1,PPP2R5B,GNG4,DDC,MAPK12,KIF5C,GNAQ,KIF5A,SCN1A,PPP2R5A,CREB3,GNB5,GSK3A,PRKACG,PLCB3,BMAL1,CALML4,GNAI2,CAMK2D,MAPK14,PPP2R1A,PPP1CC,ATF4,GNB3,TH,GNG8,MAPK9,CLOCK,ITPR1,DRD5,AKT1,CREB5,ADCY5,COMT,PPP1CB,PPP2R3A,PPP2R3C,PPP2R2C,GNB2,GRIA4,GNB1,PRKCB,ITPR3,MAPK11,SLC6A3,PPP2CB,KCNJ3,PPP2R5E,CREB3L4,GNG2,CREB1,PRKACA,ARRB2,PLCB2,GNAS,GNAI1,PPP3CA,GNGT1,GNGT2,PPP2R5C,GNG5,GNB4,FOS,DRD1,DRD2,PLCB1,GNG7,GRIA1,PPP2R5D,PPP2R2A,PRKCG,GRIN2A,CALM1,MAPK8,MAPK13,MAPK10,SLC18A2,ATF2,CREB3L3,PPP1CA,KCNJ5,CACNA1D,KCNJ6,PPP2CA,PLCB4,GSK3B,CAMK2B,PRKCA,GNG10,GNAI3,PPP3CB,PPP3CC
ko05215	Prostate cancer	0.0409034972364097	-3.19653971258621	87	82	0.013015873015873	6300	7161	3320,595,2475,1017,5155,5970,673,5291,3265,6654,5296,1869,3551,1387,84699,5894,8503,10488,1956,3845,6934,6655,1026,354,9134,5154,468,1027,5293,898,80310,1871,2885,5925,9586,207,1499,2260,2932,4790,1147,56034,83439,208,3480,5170,4893,6932,10000,1870,64764,4824,842,5605,5594,3479,51176,1950,90993,1385,596,6716,148327,3630,5295,5159,7039,5290,5595,5604,7157,2950,5156,2064,2263,5728,3645,4792,3326,2033,2308,4193	HSP90AA1,CCND1,MTOR,CDK2,PDGFB,RELA,BRAF,PIK3CB,HRAS,SOS1,PIK3R2,E2F1,IKBKB,CREBBP,CREB3L3,RAF1,PIK3R3,CREB3,EGFR,KRAS,TCF7L2,SOS2,CDKN1A,KLK3,CCNE2,PDGFA,ATF4,CDKN1B,PIK3CD,CCNE1,PDGFD,E2F3,GRB2,RB1,CREB5,AKT1,CTNNB1,FGFR1,GSK3B,NFKB1,CHUK,PDGFC,TCF7L1,AKT2,IGF1R,PDPK1,NRAS,TCF7,AKT3,E2F2,CREB3L2,NKX3-1,CASP9,MAP2K2,MAPK1,IGF1,LEF1,EGF,CREB3L1,CREB1,BCL2,SRD5A2,CREB3L4,INS,PIK3R1,PDGFRB,TGFA,PIK3CA,MAPK3,MAP2K1,TP53,GSTP1,PDGFRA,ERBB2,FGFR2,PTEN,INSRR,NFKBIA,HSP90AB1,EP300,FOXO1,MDM2
hsa05215	Prostate cancer	0.0409034972364097	-3.19653971258621	87	82	0.013015873015873	6300	7161	2475,1017,5155,5970,3320,595,6654,673,5291,3265,84699,5894,5296,3551,1869,1387,10488,1956,8503,1026,354,3845,6934,6655,5293,1027,898,80310,468,9134,5154,2885,1871,5925,9586,207,4790,1499,2260,2932,56034,83439,3480,208,1147,4893,6932,10000,5170,1870,64764,4824,842,3479,51176,5605,5594,1385,90993,596,6716,1950,5159,5295,7039,5290,3630,148327,5604,5595,2950,7157,4792,3645,2033,3326,4193,2308,5156,2064,5728,2263	MTOR,CDK2,PDGFB,RELA,HSP90AA1,CCND1,SOS1,BRAF,PIK3CB,HRAS,CREB3L3,RAF1,PIK3R2,IKBKB,E2F1,CREBBP,CREB3,EGFR,PIK3R3,CDKN1A,KLK3,KRAS,TCF7L2,SOS2,PIK3CD,CDKN1B,CCNE1,PDGFD,ATF4,CCNE2,PDGFA,GRB2,E2F3,RB1,CREB5,AKT1,NFKB1,CTNNB1,FGFR1,GSK3B,PDGFC,TCF7L1,IGF1R,AKT2,CHUK,NRAS,TCF7,AKT3,PDPK1,E2F2,CREB3L2,NKX3-1,CASP9,IGF1,LEF1,MAP2K2,MAPK1,CREB1,CREB3L1,BCL2,SRD5A2,EGF,PDGFRB,PIK3R1,TGFA,PIK3CA,INS,CREB3L4,MAP2K1,MAPK3,GSTP1,TP53,NFKBIA,INSRR,EP300,HSP90AB1,MDM2,FOXO1,PDGFRA,ERBB2,PTEN,FGFR2
hsa05211	Renal cell carcinoma	0.0416491641431507	-3.17847397916248	64	61	0.00968253968253968	6300	7161	8503,4233,6921,5894,112398,2034,1387,10298,9915,5296,5879,7040,5058,7428,6654,5291,9978,3265,673,201163,5906,5155,6923,2549,207,2885,998,2113,5293,5062,112399,6513,8453,6655,3845,57144,2889,5781,5594,5605,1398,7042,7043,10000,7422,4893,208,2033,3082,56924,5908,2271,5604,3725,5595,54583,405,7039,5295,5290,3091	PIK3R3,MET,ELOC,RAF1,EGLN2,EPAS1,CREBBP,PAK4,ARNT2,PIK3R2,RAC1,TGFB1,PAK1,VHL,SOS1,PIK3CB,RBX1,HRAS,BRAF,FLCN,RAP1A,PDGFB,ELOB,GAB1,AKT1,GRB2,CDC42,ETS1,PIK3CD,PAK2,EGLN3,SLC2A1,CUL2,SOS2,KRAS,PAK5,RAPGEF1,PTPN11,MAPK1,MAP2K2,CRK,TGFB2,TGFB3,AKT3,VEGFA,NRAS,AKT2,EP300,HGF,PAK6,RAP1B,FH,MAP2K1,JUN,MAPK3,EGLN1,ARNT,TGFA,PIK3R1,PIK3CA,HIF1A
ko05211	Renal cell carcinoma	0.0416491641431507	-3.17847397916248	64	61	0.00968253968253968	6300	7161	7039,5295,5290,3091,5604,3725,5595,54583,2271,405,3082,2033,5908,56924,208,4893,10000,7422,1398,7042,7043,2889,5781,5594,5605,8453,6513,57144,3845,6655,5293,2113,5062,112399,2885,2549,207,998,6923,5906,5155,201163,5058,7428,6654,673,5291,9978,3265,5894,112398,10298,9915,5296,5879,7040,2034,1387,4233,8503,6921	TGFA,PIK3R1,PIK3CA,HIF1A,MAP2K1,JUN,MAPK3,EGLN1,FH,ARNT,HGF,EP300,RAP1B,PAK6,AKT2,NRAS,AKT3,VEGFA,CRK,TGFB2,TGFB3,RAPGEF1,PTPN11,MAPK1,MAP2K2,CUL2,SLC2A1,PAK5,KRAS,SOS2,PIK3CD,ETS1,PAK2,EGLN3,GRB2,GAB1,AKT1,CDC42,ELOB,RAP1A,PDGFB,FLCN,PAK1,VHL,SOS1,BRAF,PIK3CB,RBX1,HRAS,RAF1,EGLN2,PAK4,ARNT2,PIK3R2,RAC1,TGFB1,EPAS1,CREBBP,MET,PIK3R3,ELOC
hsa04918	Thyroid hormone synthesis	0.0472052744977844	-3.05324964479954	74	70	0.0111111111111111	6300	7161	5332,3708,2876,477,2880,5578,9586,482,111,2877,9601,486,7270,468,3309,7253,7252,107,10488,476,5568,481,5331,112,1386,257202,84699,7173,5172,23236,2776,2936,7038,5582,433,1081,5330,213,114,480,2778,50506,2882,432,821,5567,113,148327,115,1388,90993,1385,8458,5566,109,5579,3710,196883,7276,3709,64764,108,6528,493869,4036,2878,478,483,7849,389434	PLCB4,ITPR1,GPX1,ATP1A2,GPX5,PRKCA,CREB5,ATP1B2,ADCY5,GPX2,PDIA4,FXYD2,TTF1,ATF4,HSPA5,TSHR,TSHB,ADCY1,CREB3,ATP1A1,PRKACG,ATP1B1,PLCB3,ADCY6,ATF2,GPX6,CREB3L3,TPO,SLC26A4,PLCB1,GNAQ,GSR,TG,PRKCG,ASGR2,CGA,PLCB2,ALB,ADCY8,ATP1A4,GNAS,DUOX2,GPX7,ASGR1,CANX,PRKACB,ADCY7,CREB3L4,ADCY9,ATF6B,CREB3L1,CREB1,TTF2,PRKACA,ADCY3,PRKCB,ITPR3,ADCY4,TTR,ITPR2,CREB3L2,ADCY2,SLC5A5,GPX8,LRP2,GPX3,ATP1A3,ATP1B3,PAX8,IYD
ko04918	Thyroid hormone synthesis	0.0472052744977844	-3.05324964479954	74	70	0.0111111111111111	6300	7161	196883,5579,3710,108,64764,3709,7276,4036,493869,6528,389434,7849,483,2878,478,480,114,213,5330,1081,432,2882,50506,2778,148327,113,5567,821,109,5566,8458,1385,90993,115,1388,1386,112,5331,5568,481,476,10488,84699,257202,2776,23236,5172,7173,433,5582,7038,2936,2876,3708,5332,2877,9601,111,482,9586,5578,2880,477,468,7270,486,107,7252,7253,3309	ADCY4,PRKCB,ITPR3,ADCY2,CREB3L2,ITPR2,TTR,LRP2,GPX8,SLC5A5,IYD,PAX8,ATP1B3,GPX3,ATP1A3,ATP1A4,ADCY8,ALB,PLCB2,CGA,ASGR1,GPX7,DUOX2,GNAS,CREB3L4,ADCY7,PRKACB,CANX,ADCY3,PRKACA,TTF2,CREB1,CREB3L1,ADCY9,ATF6B,ATF2,ADCY6,PLCB3,PRKACG,ATP1B1,ATP1A1,CREB3,CREB3L3,GPX6,GNAQ,PLCB1,SLC26A4,TPO,ASGR2,PRKCG,TG,GSR,GPX1,ITPR1,PLCB4,GPX2,PDIA4,ADCY5,ATP1B2,CREB5,PRKCA,GPX5,ATP1A2,ATF4,TTF1,FXYD2,ADCY1,TSHB,TSHR,HSPA5
ko04510	Focal adhesion	0.0473584613815317	-3.05000977665516	198	182	0.0288888888888889	6300	7161	3791,7791,3695,1277,5923,1280,25759,7057,3082,8516,5500,23396,3913,3912,6696,3371,60,5579,5829,6655,340156,7424,824,3675,5062,4636,1297,998,5578,2932,4660,9564,595,5155,5582,1293,5291,3265,5296,5879,8503,71,5599,858,1793,1950,29780,596,3690,1311,5747,5159,2317,5881,7450,1285,6464,3911,5595,56924,1101,2064,3679,3480,56034,93408,7423,7422,2321,7143,22798,53358,5293,207,4659,387,3914,5906,7414,894,673,4633,5649,2324,10398,7059,10451,3655,5295,857,55742,3725,5728,5156,5908,1298,3694,3676,3685,2889,3381,7410,329,5154,1299,859,2909,10319,256076,54776,1282,8515,1278,3674,7058,5880,3691,131873,87,6654,3918,3910,10298,5499,394,3696,4233,5602,1956,85366,2534,58498,3672,3673,5290,7060,3908,5604,896,63923,10627,2335,7408,64098,208,5170,91807,10000,4638,1398,3611,5594,3688,3680,1284,3479,83660,57144,3693,7409,5501,80310,284217,6714,2885,9475,1729,1499,5601,22801,103910,330,1286,81,5058,3915,399694,5894,7148,2318,3909,5228	KDR,ZYX,ITGB7,COL1A1,RASGRF1,COL2A1,SHC2,THBS1,HGF,ITGA8,PPP1CB,PIP5K1C,LAMB2,LAMB1,SPP1,TNC,ACTB,PRKCB,PXN,SOS2,MYLK4,VEGFC,CAPN2,ITGA3,PAK2,MYL5,COL9A1,CDC42,PRKCA,GSK3B,PPP1R12B,BCAR1,CCND1,PDGFB,PRKCG,COL6A3,PIK3CB,HRAS,PIK3R2,RAC1,PIK3R3,ACTG1,MAPK8,CAV2,DOCK1,EGF,PARVB,BCL2,ITGB3,COMP,PTK2,PDGFRB,FLNB,RAC3,VWF,COL4A3,SHC1,LAMA5,MAPK3,PAK6,CHAD,ERBB2,ITGA7,IGF1R,PDGFC,MYL10,VEGFB,VEGFA,FLT1,TNR,LAMB4,SHC3,PIK3CD,AKT1,PPP1R12A,RHOA,LAMB3,RAP1A,VCL,CCND2,BRAF,MYL2,RELN,FLT4,MYL9,THBS3,VAV3,ITGA6,PIK3R1,CAV1,PARVA,JUN,PTEN,PDGFRA,RAP1B,COL9A2,ITGB6,ITGA4,ITGAV,RAPGEF1,IBSP,VAV2,BIRC2,PDGFA,COL9A3,CAV3,ARHGAP35,LAMC3,COL6A5,PPP1R12C,COL4A1,ITGA10,COL1A2,ITGA2B,THBS2,RAC2,ITGB4,COL6A6,ACTN1,SOS1,LAMC2,LAMA4,PAK4,PPP1CA,ARHGAP5,ITGB8,MET,MAPK10,EGFR,MYLK2,FYN,MYL7,ITGA1,ITGA2,PIK3CA,THBS4,LAMA2,MAP2K1,CCND3,TNN,MYL12A,FN1,VASP,PARVG,AKT2,PDPK1,MYLK3,AKT3,MYLK,CRK,ILK,MAPK1,ITGB1,ITGA9,COL4A2,IGF1,TLN2,PAK5,ITGB5,VAV1,PPP1CC,PDGFD,LAMA1,SRC,GRB2,ROCK2,DIAPH1,CTNNB1,MAPK9,ITGA11,MYL12B,BIRC3,COL4A4,ACTN4,PAK1,LAMC1,SHC4,RAF1,TNXB,FLNC,LAMA3,PGF
hsa04510	Focal adhesion	0.0473584613815317	-3.05000977665516	198	182	0.0288888888888889	6300	7161	5296,5879,8503,71,5599,858,595,5155,5582,1293,5291,3265,1297,998,5578,2932,4660,9564,5829,340156,6655,7424,824,3675,5062,4636,23396,3913,3912,6696,3371,60,5579,8516,5500,1277,5923,1280,25759,7057,3082,3791,7791,3695,4633,5649,2324,5906,7414,894,673,207,4659,3914,387,5293,2321,7143,22798,53358,3679,3480,56034,93408,7423,7422,7450,1285,6464,3911,5595,56924,1101,2064,1793,29780,1950,596,3690,1311,5747,5159,2317,5881,3918,3910,10298,5499,394,3696,4233,5602,1956,1278,3674,7058,5880,3691,131873,87,6654,10319,256076,54776,1282,8515,3381,7410,329,5154,1299,859,2909,3676,3685,2889,1298,3694,55742,3725,5728,5156,5908,7059,10398,10451,3655,5295,857,3915,399694,5894,2318,7148,3909,5228,103910,330,1286,81,5058,6714,2885,9475,1729,1499,5601,22801,83660,57144,3693,7409,80310,5501,284217,4638,1398,3611,5594,3680,3688,1284,3479,2335,7408,64098,208,5170,91807,10000,3908,5604,896,63923,10627,85366,2534,58498,3672,3673,5290,7060	PIK3R2,RAC1,PIK3R3,ACTG1,MAPK8,CAV2,CCND1,PDGFB,PRKCG,COL6A3,PIK3CB,HRAS,COL9A1,CDC42,PRKCA,GSK3B,PPP1R12B,BCAR1,PXN,MYLK4,SOS2,VEGFC,CAPN2,ITGA3,PAK2,MYL5,PIP5K1C,LAMB2,LAMB1,SPP1,TNC,ACTB,PRKCB,ITGA8,PPP1CB,COL1A1,RASGRF1,COL2A1,SHC2,THBS1,HGF,KDR,ZYX,ITGB7,MYL2,RELN,FLT4,RAP1A,VCL,CCND2,BRAF,AKT1,PPP1R12A,LAMB3,RHOA,PIK3CD,FLT1,TNR,LAMB4,SHC3,ITGA7,IGF1R,PDGFC,MYL10,VEGFB,VEGFA,VWF,COL4A3,SHC1,LAMA5,MAPK3,PAK6,CHAD,ERBB2,DOCK1,PARVB,EGF,BCL2,ITGB3,COMP,PTK2,PDGFRB,FLNB,RAC3,LAMC2,LAMA4,PAK4,PPP1CA,ARHGAP5,ITGB8,MET,MAPK10,EGFR,COL1A2,ITGA2B,THBS2,RAC2,ITGB4,COL6A6,ACTN1,SOS1,LAMC3,COL6A5,PPP1R12C,COL4A1,ITGA10,IBSP,VAV2,BIRC2,PDGFA,COL9A3,CAV3,ARHGAP35,ITGA4,ITGAV,RAPGEF1,COL9A2,ITGB6,PARVA,JUN,PTEN,PDGFRA,RAP1B,THBS3,MYL9,VAV3,ITGA6,PIK3R1,CAV1,LAMC1,SHC4,RAF1,FLNC,TNXB,LAMA3,PGF,MYL12B,BIRC3,COL4A4,ACTN4,PAK1,SRC,GRB2,ROCK2,DIAPH1,CTNNB1,MAPK9,ITGA11,TLN2,PAK5,ITGB5,VAV1,PDGFD,PPP1CC,LAMA1,MYLK,CRK,ILK,MAPK1,ITGA9,ITGB1,COL4A2,IGF1,FN1,VASP,PARVG,AKT2,PDPK1,MYLK3,AKT3,LAMA2,MAP2K1,CCND3,TNN,MYL12A,MYLK2,FYN,MYL7,ITGA1,ITGA2,PIK3CA,THBS4
ko04012	ErbB signaling pathway	0.0476326311212535	-3.04423722485416	85	80	0.0126984126984127	6300	7161	208,6198,10000,4893,2065,1398,4690,53358,25,815,5579,374,5605,5594,818,1950,5290,5295,7039,5747,6464,25759,3725,5595,5604,6777,145957,8440,5335,6776,867,56924,2064,1839,5582,2475,4609,5336,6654,5058,868,3265,5291,673,6416,5894,817,5296,3084,399694,10298,1956,5599,8503,5602,1026,6655,27,57144,3845,10718,1978,5293,1027,9542,2066,6199,5062,207,6714,2549,23624,685,5578,2885,5609,2069,5601,816,2932	AKT2,RPS6KB1,AKT3,NRAS,ERBB3,CRK,NCK1,SHC3,ABL1,CAMK2A,PRKCB,AREG,MAP2K2,MAPK1,CAMK2G,EGF,PIK3CA,PIK3R1,TGFA,PTK2,SHC1,SHC2,JUN,MAPK3,MAP2K1,STAT5B,NRG4,NCK2,PLCG1,STAT5A,CBL,PAK6,ERBB2,HBEGF,PRKCG,MTOR,MYC,PLCG2,SOS1,PAK1,CBLB,HRAS,PIK3CB,BRAF,MAP2K4,RAF1,CAMK2D,PIK3R2,NRG1,SHC4,PAK4,EGFR,MAPK8,PIK3R3,MAPK10,CDKN1A,SOS2,ABL2,PAK5,KRAS,NRG3,EIF4EBP1,PIK3CD,CDKN1B,NRG2,ERBB4,RPS6KB2,PAK2,AKT1,SRC,GAB1,CBLC,BTC,PRKCA,GRB2,MAP2K7,EREG,MAPK9,CAMK2B,GSK3B
hsa04012	ErbB signaling pathway	0.0476326311212535	-3.04423722485416	85	80	0.0126984126984127	6300	7161	2069,5601,2932,816,23624,2885,5578,685,207,2549,6714,5609,1027,5293,9542,10718,1978,2066,6199,5062,1026,3845,57144,6655,27,5599,1956,5602,8503,6416,5894,10298,399694,3084,5296,817,6654,5058,868,673,3265,5291,2475,4609,5582,5336,8440,6776,5335,867,2064,1839,56924,3725,5604,5595,25759,6777,6464,145957,5290,5295,7039,5747,818,1950,5579,53358,815,25,374,5605,5594,1398,2065,4690,4893,10000,208,6198	EREG,MAPK9,GSK3B,CAMK2B,CBLC,GRB2,PRKCA,BTC,AKT1,GAB1,SRC,MAP2K7,CDKN1B,PIK3CD,NRG2,NRG3,EIF4EBP1,ERBB4,RPS6KB2,PAK2,CDKN1A,KRAS,PAK5,SOS2,ABL2,MAPK8,EGFR,MAPK10,PIK3R3,MAP2K4,RAF1,PAK4,SHC4,NRG1,PIK3R2,CAMK2D,SOS1,PAK1,CBLB,BRAF,HRAS,PIK3CB,MTOR,MYC,PRKCG,PLCG2,NCK2,STAT5A,PLCG1,CBL,ERBB2,HBEGF,PAK6,JUN,MAP2K1,MAPK3,SHC2,STAT5B,SHC1,NRG4,PIK3CA,PIK3R1,TGFA,PTK2,CAMK2G,EGF,PRKCB,SHC3,CAMK2A,ABL1,AREG,MAP2K2,MAPK1,CRK,ERBB3,NCK1,NRAS,AKT3,AKT2,RPS6KB1
ko05132	Salmonella infection	0.0476326311212535	-3.04423722485416	85	80	0.0126984126984127	6300	7161	9475,3553,3552,834,7100,83547,998,64837,4790,5601,388372,5586,1437,10094,6348,4628,147700,8936,3606,929,7879,10092,1432,3459,5879,1780,3460,5599,71,10095,2318,5603,5602,5970,29108,10109,2353,10163,375189,29941,4615,2920,6300,1781,7082,5595,3725,58484,10093,51143,3458,3569,1778,7099,2317,2921,8976,79659,4627,414062,89953,3929,3831,1783,6351,81873,79784,60,5600,5594,345456,391,3576,5585,5217,10552,23207,5216,6349,2919	ROCK2,IL1B,IL1A,CASP1,TLR5,RILP,CDC42,KLC2,NFKB1,MAPK9,CCL4L1,PKN2,CSF2,ARPC3,CCL3,MYH10,KLC3,WASF1,IL18,CD14,RAB7A,ARPC5,MAPK14,IFNGR1,RAC1,DYNC1I1,IFNGR2,MAPK8,ACTG1,ARPC1B,FLNC,MAPK13,MAPK10,RELA,PYCARD,ARPC2,FOS,WASF2,PFN4,PKN3,MYD88,CXCL2,MAPK12,DYNC1I2,TJP1,MAPK3,JUN,NLRC4,ARPC4,DYNC1LI1,IFNG,IL6,DYNC1H1,TLR4,FLNB,CXCL3,WASL,DYNC2H1,MYH9,CCL3L3,KLC4,LBP,KLC1,DYNC1LI2,CCL4,ARPC5L,MYH14,ACTB,MAPK11,MAPK1,PFN3,RHOG,CXCL8,PKN1,PFN2,ARPC1A,PLEKHM2,PFN1,CCL3L1,CXCL1
hsa05132	Salmonella infection	0.0476326311212535	-3.04423722485416	85	80	0.0126984126984127	6300	7161	29108,5970,375189,29941,2920,4615,6300,10109,2353,10163,3459,1432,5879,1780,7879,10092,71,10095,2318,5603,5602,3460,5599,10094,6348,4628,147700,1437,8936,3606,929,834,7100,83547,998,9475,3553,3552,5586,64837,4790,5601,388372,5217,3576,5585,5216,6349,2919,10552,23207,1783,3831,3929,79659,4627,89953,414062,5600,345456,5594,391,6351,81873,79784,60,1778,8976,7099,2921,2317,58484,1781,7082,5595,3725,3458,3569,10093,51143	PYCARD,RELA,PFN4,PKN3,CXCL2,MYD88,MAPK12,ARPC2,FOS,WASF2,IFNGR1,MAPK14,RAC1,DYNC1I1,RAB7A,ARPC5,ACTG1,ARPC1B,FLNC,MAPK13,MAPK10,IFNGR2,MAPK8,ARPC3,CCL3,MYH10,KLC3,CSF2,WASF1,IL18,CD14,CASP1,TLR5,RILP,CDC42,ROCK2,IL1B,IL1A,PKN2,KLC2,NFKB1,MAPK9,CCL4L1,PFN2,CXCL8,PKN1,PFN1,CCL3L1,CXCL1,ARPC1A,PLEKHM2,DYNC1LI2,KLC1,LBP,DYNC2H1,MYH9,KLC4,CCL3L3,MAPK11,PFN3,MAPK1,RHOG,CCL4,ARPC5L,MYH14,ACTB,DYNC1H1,WASL,TLR4,CXCL3,FLNB,NLRC4,DYNC1I2,TJP1,MAPK3,JUN,IFNG,IL6,ARPC4,DYNC1LI1
hsa04911	Insulin secretion	0.0476326311212535	-3.04423722485416	85	80	0.0126984126984127	6300	7161	5332,27094,816,3780,482,9586,477,5578,54795,111,6833,486,3779,776,2641,2767,468,117,6513,2740,107,476,10242,5568,481,11069,10488,112,1386,3767,5331,84699,817,6262,6616,886,2776,23236,5582,3651,116,9699,27345,114,5864,5330,480,2778,3782,148327,3630,157855,113,27445,5567,115,1388,90993,1385,818,109,5566,815,3710,5579,196883,2695,108,3781,64764,2645,6844,6514,775,1131,3778,478,483,779,2864	PLCB4,KCNMB3,CAMK2B,KCNN1,ATP1B2,CREB5,ATP1A2,PRKCA,TRPM4,ADCY5,ABCC8,FXYD2,KCNMB1,CACNA1D,GCG,GNA11,ATF4,ADCYAP1R1,SLC2A1,GLP1R,ADCY1,ATP1A1,KCNMB2,PRKACG,ATP1B1,RAPGEF4,CREB3,ADCY6,ATF2,KCNJ11,PLCB3,CREB3L3,CAMK2D,RYR2,SNAP25,CCKAR,GNAQ,PLCB1,PRKCG,PDX1,ADCYAP1,RIMS2,KCNMB4,ADCY8,RAB3A,PLCB2,ATP1A4,GNAS,KCNN3,CREB3L4,INS,KCNU1,ADCY7,PCLO,PRKACB,ADCY9,ATF6B,CREB3L1,CREB1,CAMK2G,ADCY3,PRKACA,CAMK2A,ITPR3,PRKCB,ADCY4,GIP,ADCY2,KCNN2,CREB3L2,GCK,VAMP2,SLC2A2,CACNA1C,CHRM3,KCNMA1,ATP1A3,ATP1B3,CACNA1S,FFAR1
ko04151	PI3K-Akt signaling pathway	0.0487162598938945	-3.02174242589396	341	310	0.0492063492063492	6300	7161	2475,1017,4609,3320,64223,11140,1286,29941,7249,2264,5894,3565,3915,2252,5228,2253,10488,3909,3439,3559,7148,1026,94235,284217,80310,200186,1978,3693,2257,2784,2885,7532,7533,22801,1021,118788,3452,5585,208,2335,10000,57121,5617,5170,2261,3479,51378,23035,1284,3680,3688,6446,5594,3445,5521,7060,5290,6194,3673,51764,3672,5604,63923,896,3908,3558,7248,5526,2786,3456,3674,930,1278,5970,6654,59345,131873,3691,23533,3449,7058,3696,3574,84699,7531,2309,3560,3918,3910,6009,1956,26291,1386,4233,3381,2256,1027,2249,1299,1975,898,5154,5105,1282,9470,2790,256076,10319,8515,3643,1129,2251,5523,2248,3694,55012,5522,2783,2782,1298,3164,146850,285,2149,117145,3454,3676,1435,5516,1128,7534,3718,9623,356,3685,54331,92579,3655,3440,3448,7059,6794,5295,2688,26281,7157,5527,2254,7097,2787,4193,3569,5156,2998,5728,2263,54541,3441,8817,1946,5525,23239,894,1902,2324,10681,5649,1019,3845,1441,3716,5293,5518,4602,468,2259,9180,207,9586,3914,5008,4790,5618,5586,3570,2246,56034,3480,2057,5519,1147,8115,3679,4893,10110,7422,7423,3444,23566,1944,2321,6256,10018,64764,2791,5562,5563,7010,2250,7143,22798,1977,284,5605,55970,1388,90993,4846,596,1950,3815,3566,5159,5747,7529,5934,3630,1311,3690,5595,3911,1285,7450,4803,6850,57818,23678,1101,672,4254,2788,1293,5528,5520,5155,595,10971,2997,3265,5291,5879,5296,3551,4804,57521,8503,8822,9965,3443,7424,6655,3442,1436,5515,6199,9134,3717,3675,5578,1297,2247,598,2932,2260,3575,1942,1943,6198,5294,8516,2056,2538,3371,3912,6696,3913,3562,842,10161,2255,2690,1385,3791,1969,7099,5529,3695,148327,1280,2792,3667,2793,1277,27006,4170,3082,8074,7057,3326,3455	MTOR,CDK2,MYC,HSP90AA1,MLST8,CDC37,COL4A4,PKN3,TSC2,FGFR4,RAF1,IL4,LAMC1,FGF7,PGF,FGF8,CREB3,LAMA3,IFNA1,IL2RA,TNXB,CDKN1A,GNG8,LAMA1,PDGFD,CRTC2,EIF4EBP1,ITGB5,FGF12,GNB3,GRB2,YWHAG,YWHAH,ITGA11,CDK6,PIK3AP1,IFNA21,PKN1,AKT2,FN1,AKT3,LPAR5,PRL,PDPK1,FGFR3,IGF1,ANGPT4,PHLPP2,COL4A2,ITGA9,ITGB1,SGK1,MAPK1,IFNA8,PPP2R2B,THBS4,PIK3CA,RPS6,ITGA2,GNG13,ITGA1,MAP2K1,TNN,CCND3,LAMA2,IL2,TSC1,PPP2R5B,GNG4,IFNB1,ITGA2B,CD19,COL1A2,RELA,SOS1,GNB4,COL6A6,ITGB4,PIK3R5,IFNA16,THBS2,ITGB8,IL7,CREB3L3,YWHAE,FOXO3,IL2RB,LAMC2,LAMA4,RHEB,EGFR,FGF21,ATF2,MET,IBSP,FGF11,CDKN1B,FGF4,COL9A3,EIF4B,CCNE1,PDGFA,PCK1,COL4A1,EIF4E2,GNG10,COL6A5,LAMC3,ITGA10,INSR,CHRM2,FGF6,PPP2R3A,FGF3,ITGB6,PPP2R3C,PPP2R2C,GNB2,GNB1,COL9A2,NR4A1,PIK3R6,ANGPT2,F2R,THEM4,IFNAR1,ITGA4,CSF1,PPP2CB,CHRM1,YWHAZ,JAK3,TCL1B,FASLG,ITGAV,GNG2,G6PC3,ITGA6,IFNA2,IFNA14,THBS3,STK11,PIK3R1,GH1,FGF20,TP53,PPP2R5C,FGF9,TLR2,GNG5,MDM2,IL6,PDGFRA,GYS2,PTEN,FGFR2,DDIT4,IFNA4,FGF18,EFNA5,PPP2R5A,PHLPP1,CCND2,LPAR1,FLT4,GNB5,RELN,CDK4,KRAS,CSF3R,JAK1,PIK3CD,PPP2R1A,MYB,ATF4,FGF14,OSMR,AKT1,CREB5,LAMB3,OSM,NFKB1,PRLR,PKN2,IL6R,FGF1,PDGFC,IGF1R,EPOR,PPP2R1B,CHUK,TCL1A,ITGA7,NRAS,SGK2,VEGFA,VEGFB,IFNA7,LPAR3,EFNA3,FLT1,RXRA,BCL2L11,CREB3L2,GNG11,PRKAA1,PRKAA2,TEK,FGF5,TNR,LAMB4,EIF4E,ANGPT1,MAP2K2,GNG12,ATF6B,CREB3L1,NOS3,BCL2,EGF,KIT,IL4R,PDGFRB,PTK2,YWHAB,RBL2,INS,COMP,ITGB3,MAPK3,LAMA5,COL4A3,VWF,NGF,SYK,G6PC2,SGK3,CHAD,BRCA1,KITLG,GNG7,COL6A3,PPP2R5D,PPP2R2A,PDGFB,CCND1,YWHAQ,GYS1,HRAS,PIK3CB,RAC1,PIK3R2,IKBKB,NGFR,RPTOR,PIK3R3,FGF17,FGF19,IFNA6,VEGFC,SOS2,IFNA5,CSF1R,PPP2CA,RPS6KB2,CCNE2,JAK2,ITGA3,PRKCA,COL9A1,FGF2,BCL2L1,GSK3B,FGFR1,IL7R,EFNA1,EFNA2,RPS6KB1,PIK3CG,ITGA8,EPO,G6PC1,TNC,LAMB1,SPP1,LAMB2,IL3,CASP9,LPAR6,FGF10,GHR,CREB1,KDR,EPHA2,TLR4,PPP2R5E,ITGB7,CREB3L4,COL2A1,GNGT1,IRS1,GNGT2,COL1A1,FGF22,MCL1,HGF,FGF23,THBS1,HSP90AB1,IFNAR2
hsa04151	PI3K-Akt signaling pathway	0.0487162598938945	-3.02174242589396	341	310	0.0492063492063492	6300	7161	3371,10161,3562,842,3913,6696,3912,2255,2690,8516,5294,6198,2056,2538,2793,1280,2792,3667,27006,1277,3326,4170,8074,7057,3082,3455,1385,3791,5529,7099,1969,148327,3695,3551,5296,5879,4804,8503,8822,57521,5155,5520,5528,1293,2788,10971,595,2997,5291,3265,5578,2247,1297,598,1943,3575,1942,2260,2932,3442,3443,7424,6655,9965,5515,1436,3675,3717,6199,9134,6256,1944,2321,64764,10018,2791,2250,7010,5563,5562,5605,55970,284,7143,22798,1977,5519,3480,2057,56034,3679,8115,1147,7423,3444,10110,7422,4893,23566,1285,3911,5595,7450,4803,57818,23678,6850,672,4254,1101,596,4846,90993,1388,1950,5159,3566,3815,3690,3630,1311,7529,5934,5747,1902,10681,2324,1019,5649,5525,1946,8817,3441,54541,23239,894,9586,2259,207,9180,5618,4790,5008,3914,3570,2246,5586,3716,1441,3845,4602,5518,5293,468,3676,3454,5516,1128,1435,3718,7534,3685,356,9623,2782,1298,2783,55012,5522,2248,5523,3694,285,3164,146850,2149,117145,7157,26281,2787,7097,5527,2254,4193,2998,5728,2263,5156,3569,3655,92579,54331,7059,3440,3448,5295,6794,2688,2309,7531,84699,3696,3574,3918,3910,3560,6009,1956,26291,1386,4233,5970,1278,930,3674,3456,23533,3691,59345,131873,6654,7058,3449,256076,1282,9470,2790,5105,10319,3643,8515,2251,1129,3381,2256,898,1299,1975,2249,1027,5154,3479,51378,2261,5594,6446,3680,3688,1284,23035,208,5585,2335,57121,10000,5170,5617,3908,3558,63923,5604,896,7248,2786,5526,5521,3445,6194,5290,7060,3672,51764,3673,2264,5894,7249,3915,3565,3909,3439,3559,2253,10488,2252,5228,7148,4609,1017,2475,64223,3320,11140,29941,1286,2885,7533,7532,118788,1021,22801,3452,1026,94235,200186,1978,80310,284217,2784,2257,3693	TNC,LPAR6,IL3,CASP9,LAMB2,SPP1,LAMB1,FGF10,GHR,ITGA8,PIK3CG,RPS6KB1,EPO,G6PC1,GNGT2,COL2A1,GNGT1,IRS1,FGF22,COL1A1,HSP90AB1,MCL1,FGF23,THBS1,HGF,IFNAR2,CREB1,KDR,PPP2R5E,TLR4,EPHA2,CREB3L4,ITGB7,IKBKB,PIK3R2,RAC1,NGFR,PIK3R3,FGF17,RPTOR,PDGFB,PPP2R2A,PPP2R5D,COL6A3,GNG7,YWHAQ,CCND1,GYS1,PIK3CB,HRAS,PRKCA,FGF2,COL9A1,BCL2L1,EFNA2,IL7R,EFNA1,FGFR1,GSK3B,IFNA5,IFNA6,VEGFC,SOS2,FGF19,PPP2CA,CSF1R,ITGA3,JAK2,RPS6KB2,CCNE2,RXRA,EFNA3,FLT1,CREB3L2,BCL2L11,GNG11,FGF5,TEK,PRKAA2,PRKAA1,MAP2K2,GNG12,ANGPT1,TNR,LAMB4,EIF4E,PPP2R1B,IGF1R,EPOR,PDGFC,ITGA7,TCL1A,CHUK,VEGFB,IFNA7,SGK2,VEGFA,NRAS,LPAR3,COL4A3,LAMA5,MAPK3,VWF,NGF,G6PC2,SGK3,SYK,BRCA1,KITLG,CHAD,BCL2,NOS3,CREB3L1,ATF6B,EGF,PDGFRB,IL4R,KIT,ITGB3,INS,COMP,YWHAB,RBL2,PTK2,LPAR1,GNB5,FLT4,CDK4,RELN,PPP2R5A,EFNA5,FGF18,IFNA4,DDIT4,PHLPP1,CCND2,CREB5,FGF14,AKT1,OSMR,PRLR,NFKB1,OSM,LAMB3,IL6R,FGF1,PKN2,JAK1,CSF3R,KRAS,MYB,PPP2R1A,PIK3CD,ATF4,ITGA4,IFNAR1,PPP2CB,CHRM1,CSF1,JAK3,YWHAZ,ITGAV,FASLG,TCL1B,GNB1,COL9A2,GNB2,PPP2R3C,PPP2R2C,FGF3,PPP2R3A,ITGB6,ANGPT2,NR4A1,PIK3R6,F2R,THEM4,TP53,FGF20,GNG5,TLR2,PPP2R5C,FGF9,MDM2,GYS2,PTEN,FGFR2,PDGFRA,IL6,ITGA6,G6PC3,GNG2,THBS3,IFNA2,IFNA14,PIK3R1,STK11,GH1,FOXO3,YWHAE,CREB3L3,ITGB8,IL7,LAMC2,LAMA4,IL2RB,RHEB,EGFR,FGF21,ATF2,MET,RELA,COL1A2,CD19,ITGA2B,IFNB1,PIK3R5,ITGB4,GNB4,COL6A6,SOS1,THBS2,IFNA16,COL6A5,COL4A1,EIF4E2,GNG10,PCK1,LAMC3,INSR,ITGA10,FGF6,CHRM2,IBSP,FGF11,CCNE1,COL9A3,EIF4B,FGF4,CDKN1B,PDGFA,IGF1,ANGPT4,FGFR3,MAPK1,SGK1,ITGA9,ITGB1,COL4A2,PHLPP2,AKT2,PKN1,FN1,LPAR5,AKT3,PDPK1,PRL,LAMA2,IL2,TNN,MAP2K1,CCND3,TSC1,GNG4,PPP2R5B,PPP2R2B,IFNA8,RPS6,PIK3CA,THBS4,ITGA1,GNG13,ITGA2,FGFR4,RAF1,TSC2,LAMC1,IL4,LAMA3,IFNA1,IL2RA,FGF8,CREB3,FGF7,PGF,TNXB,MYC,CDK2,MTOR,MLST8,HSP90AA1,CDC37,PKN3,COL4A4,GRB2,YWHAH,YWHAG,PIK3AP1,CDK6,ITGA11,IFNA21,CDKN1A,GNG8,CRTC2,EIF4EBP1,PDGFD,LAMA1,GNB3,FGF12,ITGB5
ko04913	Ovarian steroidogenesis	0.0502172383259417	-2.99139691828327	50	48	0.00761904761904762	6300	7161	1588,5321,3630,5567,113,115,109,654,100137049,5566,114,3284,123745,1081,2488,2778,3294,8644,3972,1545,3973,8605,51478,3480,255189,3479,1573,5743,196883,2661,283748,108,1583,3292,107,949,3643,3949,10965,111,240,1543,2492,6770,5568,112,3283,1586	CYP19A1,PLA2G4A,INS,PRKACB,ADCY7,ADCY9,ADCY3,BMP6,PLA2G4B,PRKACA,ADCY8,HSD3B2,PLA2G4E,CGA,FSHB,GNAS,HSD17B2,AKR1C3,LHB,CYP1B1,LHCGR,PLA2G4C,HSD17B7,IGF1R,PLA2G4F,IGF1,CYP2J2,PTGS2,ADCY4,GDF9,PLA2G4D,ADCY2,CYP11A1,HSD17B1,ADCY1,SCARB1,INSR,LDLR,ACOT2,ADCY5,ALOX5,CYP1A1,FSHR,STAR,PRKACG,ADCY6,HSD3B1,CYP17A1
hsa04913	Ovarian steroidogenesis	0.0502172383259417	-2.99139691828327	50	48	0.00761904761904762	6300	7161	2492,6770,1543,3283,1586,5568,112,107,3292,1583,3949,240,111,10965,3643,949,255189,3480,8644,3294,51478,8605,3973,3972,1545,283748,2661,108,5743,1573,3479,196883,115,5566,654,100137049,109,1588,113,5567,3630,5321,2778,2488,1081,3284,123745,114	FSHR,STAR,CYP1A1,HSD3B1,CYP17A1,PRKACG,ADCY6,ADCY1,HSD17B1,CYP11A1,LDLR,ALOX5,ADCY5,ACOT2,INSR,SCARB1,PLA2G4F,IGF1R,AKR1C3,HSD17B2,HSD17B7,PLA2G4C,LHCGR,LHB,CYP1B1,PLA2G4D,GDF9,ADCY2,PTGS2,CYP2J2,IGF1,ADCY4,ADCY9,PRKACA,BMP6,PLA2G4B,ADCY3,CYP19A1,ADCY7,PRKACB,INS,PLA2G4A,GNAS,FSHB,CGA,HSD3B2,PLA2G4E,ADCY8
hsa04010	MAPK signaling pathway	0.0502709451833448	-2.99032799931905	255	233	0.036984126984127	6300	7161	9344,7132,408,6885,5608,5600,1326,3554,2255,5579,7189,10125,3312,1849,784,3304,100137049,5566,4208,4775,8074,27006,5922,5923,5598,5530,51295,3265,2005,4215,1848,5582,5155,8822,5599,3551,5879,4763,5062,776,627,781,6655,7867,9965,11184,2260,80824,27091,3306,2247,5609,998,5578,9064,775,4908,4893,4149,1147,6195,5605,55970,2768,2250,5921,7124,59285,5494,5321,59284,5567,5159,5881,2317,1950,5971,9020,10235,4803,4616,5535,10368,783,5595,673,6300,23162,3727,93589,2122,8817,5906,5924,8986,1432,7040,115727,7048,4915,468,55799,3845,4909,2246,10746,4790,2259,207,3553,3552,4137,5778,11221,3305,9254,3164,9175,2248,1843,255189,356,51347,4791,23118,9479,6237,283748,8911,7046,2263,5908,5156,409,4216,1847,2254,7157,26281,3725,5880,2353,6654,5970,2872,1386,5603,5602,4342,786,1956,26291,9693,10369,3310,5154,5607,4214,2249,1647,2256,10912,3925,2251,22800,5532,5533,59283,8605,836,10000,8912,8913,22808,208,773,779,51776,5534,84867,5594,57551,2261,7043,7042,25780,1398,1616,9261,5801,10454,9448,5495,1846,785,123745,6722,6788,100506012,4217,5604,5536,27092,8649,8491,5058,4914,777,4609,6789,2318,5568,5871,2252,1850,2253,994,6416,2264,5894,929,3315,1844,2257,9252,4296,5606,6196,5601,4772,355,7850,2885	TAOK2,TNFRSF1A,ARRB1,MAP3K7,MAP2K6,MAPK11,MAP3K8,IL1R1,FGF10,PRKCB,TRAF6,RASGRP1,HSPA8,DUSP7,CACNB3,HSPA1B,PLA2G4B,PRKACA,MEF2C,NFATC3,FGF23,FGF22,RASA2,RASGRF1,MAPK7,PPP3CA,ECSIT,HRAS,ELK4,MAP3K3,DUSP6,PRKCG,PDGFB,FGF17,MAPK8,IKBKB,RAC1,NF1,PAK2,CACNA1D,BDNF,CACNA2D1,SOS2,MAPKAPK3,FGF19,MAP4K1,FGFR1,DUSP16,CACNG5,HSPA2,FGF2,MAP2K7,CDC42,PRKCA,MAP3K6,CACNA1C,NTF3,NRAS,MAX,CHUK,RPS6KA1,MAP2K2,GNG12,GNA12,FGF5,RASA1,TNF,CACNG6,PPM1A,PLA2G4A,CACNG7,PRKACB,PDGFRB,RAC3,FLNB,EGF,RELB,MAP3K14,RASGRP2,NGF,GADD45B,PPP3R2,CACNG3,CACNB2,MAPK3,BRAF,MAPK12,MAPK8IP3,JUND,CACNA2D4,MECOM,FGF18,RAP1A,RASGRF2,RPS6KA4,MAPK14,TGFB1,RASGRP4,TGFBR2,NTRK2,ATF4,CACNA2D3,KRAS,NTF4,FGF1,MAP3K2,NFKB1,FGF14,AKT1,IL1B,IL1A,MAPT,PTPN7,DUSP10,HSPA1L,CACNA2D2,NR4A1,MAP3K13,FGF3,DUSP1,PLA2G4F,FASLG,TAOK3,NFKB2,TAB2,MAPK8IP1,RRAS,PLA2G4D,CACNA1I,TGFBR1,FGFR2,RAP1B,PDGFRA,ARRB2,MAP3K4,DUSP5,FGF9,TP53,FGF20,JUN,RAC2,FOS,SOS1,RELA,MKNK2,ATF2,MAPK13,MAPK10,MOS,CACNG1,EGFR,FGF21,RAPGEF2,CACNG2,HSPA6,PDGFA,MAP2K5,MAP3K1,FGF4,GADD45A,FGF11,GADD45G,STMN1,FGF6,RRAS2,PPP3CB,PPP3CC,CACNG8,PLA2G4C,CASP3,AKT3,CACNA1H,CACNA1G,MRAS,AKT2,CACNA1A,CACNA1S,MAP3K20,PPP3R1,PTPN5,MAPK1,TAOK1,FGFR3,TGFB3,TGFB2,RASGRP3,CRK,DAXX,MAPKAPK2,PTPRR,TAB1,MAP4K4,PPM1B,DUSP4,CACNB4,PLA2G4E,SRF,STK3,PPP5D1P,MAP3K5,MAP2K1,PPP5C,CACNG4,LAMTOR3,MAP4K3,PAK1,NTRK1,CACNA1E,MYC,STK4,FLNC,PRKACG,MAP4K2,FGF7,DUSP8,FGF8,CDC25B,MAP2K4,FGFR4,RAF1,CD14,HSPB1,DUSP2,FGF12,RPS6KA5,MAP3K11,MAP2K3,RPS6KA2,MAPK9,NFATC1,FAS,IL1R2,GRB2
ko04010	MAPK signaling pathway	0.0502709451833448	-2.99032799931905	255	233	0.036984126984127	6300	7161	207,2259,3552,3553,2246,4790,10746,3845,55799,4909,4915,468,1432,7048,7040,115727,8986,5924,3727,93589,5906,2122,8817,6300,673,23162,4803,4616,5595,783,5535,10368,9020,10235,5971,1950,5321,5567,59284,5159,2317,5881,59285,7124,5921,5494,5605,55970,2250,2768,4149,1147,6195,775,9064,4908,4893,5609,3306,2247,998,5578,2260,27091,80824,7867,6655,9965,11184,5062,781,776,627,3551,5879,4763,8822,5599,4215,2005,5155,1848,5582,3265,27006,5923,5922,51295,5530,5598,4775,8074,3304,784,100137049,5566,4208,3312,1849,10125,7189,5608,5600,3554,1326,2255,5579,6885,9344,7132,408,7850,2885,5601,6196,355,4772,4296,5606,3315,1844,2257,929,9252,2264,5894,6416,994,2318,6789,5568,2253,1850,5871,2252,4609,777,4914,5536,8649,27092,8491,5058,6722,6788,100506012,5604,4217,1846,785,5495,123745,9448,10454,5801,1616,9261,7042,7043,25780,1398,84867,57551,5594,5534,2261,22808,208,779,51776,773,8605,836,10000,8913,8912,5533,5532,59283,22800,2251,3925,2256,10912,10369,9693,5154,3310,1647,4214,2249,5607,1386,5602,5603,786,4342,1956,26291,2872,5970,5880,2353,6654,2254,1847,7157,3725,26281,2263,5156,5908,4216,409,8911,7046,6237,283748,4791,51347,356,23118,9479,3164,9254,9175,255189,2248,1843,4137,5778,11221,3305	AKT1,FGF14,IL1A,IL1B,FGF1,NFKB1,MAP3K2,KRAS,CACNA2D3,NTF4,NTRK2,ATF4,MAPK14,TGFBR2,TGFB1,RASGRP4,RPS6KA4,RASGRF2,JUND,CACNA2D4,RAP1A,MECOM,FGF18,MAPK12,BRAF,MAPK8IP3,NGF,GADD45B,MAPK3,CACNB2,PPP3R2,CACNG3,MAP3K14,RASGRP2,RELB,EGF,PLA2G4A,PRKACB,CACNG7,PDGFRB,FLNB,RAC3,CACNG6,TNF,RASA1,PPM1A,MAP2K2,GNG12,FGF5,GNA12,MAX,CHUK,RPS6KA1,CACNA1C,MAP3K6,NTF3,NRAS,MAP2K7,HSPA2,FGF2,CDC42,PRKCA,FGFR1,CACNG5,DUSP16,MAPKAPK3,SOS2,FGF19,MAP4K1,PAK2,CACNA2D1,CACNA1D,BDNF,IKBKB,RAC1,NF1,FGF17,MAPK8,MAP3K3,ELK4,PDGFB,DUSP6,PRKCG,HRAS,FGF22,RASGRF1,RASA2,ECSIT,PPP3CA,MAPK7,NFATC3,FGF23,HSPA1B,CACNB3,PLA2G4B,PRKACA,MEF2C,HSPA8,DUSP7,RASGRP1,TRAF6,MAP2K6,MAPK11,IL1R1,MAP3K8,FGF10,PRKCB,MAP3K7,TAOK2,TNFRSF1A,ARRB1,IL1R2,GRB2,MAPK9,RPS6KA2,FAS,NFATC1,MAP3K11,MAP2K3,HSPB1,DUSP2,FGF12,CD14,RPS6KA5,FGFR4,RAF1,MAP2K4,CDC25B,FLNC,STK4,PRKACG,FGF8,DUSP8,MAP4K2,FGF7,MYC,CACNA1E,NTRK1,PPP5C,LAMTOR3,CACNG4,MAP4K3,PAK1,SRF,STK3,PPP5D1P,MAP2K1,MAP3K5,DUSP4,CACNB4,PPM1B,PLA2G4E,MAP4K4,TAB1,PTPRR,DAXX,MAPKAPK2,TGFB2,TGFB3,RASGRP3,CRK,PTPN5,TAOK1,MAPK1,PPP3R1,FGFR3,MRAS,AKT2,CACNA1S,MAP3K20,CACNA1A,PLA2G4C,CASP3,AKT3,CACNA1G,CACNA1H,PPP3CC,PPP3CB,CACNG8,RRAS2,FGF6,STMN1,FGF11,GADD45G,CACNG2,RAPGEF2,PDGFA,HSPA6,GADD45A,MAP3K1,FGF4,MAP2K5,ATF2,MAPK10,MAPK13,CACNG1,MOS,EGFR,FGF21,MKNK2,RELA,RAC2,FOS,SOS1,FGF9,DUSP5,TP53,JUN,FGF20,FGFR2,PDGFRA,RAP1B,MAP3K4,ARRB2,CACNA1I,TGFBR1,RRAS,PLA2G4D,NFKB2,TAOK3,FASLG,TAB2,MAPK8IP1,NR4A1,CACNA2D2,MAP3K13,PLA2G4F,FGF3,DUSP1,MAPT,PTPN7,DUSP10,HSPA1L
hsa00980	Metabolism of xenobiotics by cytochrome P450	0.0511432088535369	-2.97312556463593	73	69	0.010952380952381	6300	7161	9446,2947,124,79799,1553,2939,2946,7365,221357,1543,2941,119391,2949,125,7364,4259,128,574537,1559,1565,2952,2953,54658,220,4257,54578,130,1572,29785,54490,22977,1645,10941,4258,7363,1555,873,218,127,27306,1545,54600,1548,874,131,6822,221,2944,54579,54577,54576,2938,2950,27294,10720,2052,54659,7366,373156,2948,54657,2940,222,1577,126,54575,1544,1576,3290	GSTO1,GSTM3,ADH1A,UGT2A3,CYP2A13,GSTA2,GSTM2,UGT2B10,GSTA5,CYP1A1,GSTA4,GSTO2,GSTM5,ADH1B,UGT2B7,MGST3,ADH5,UGT2A2,CYP2C9,CYP2D6,GSTT1,GSTT2,UGT1A1,ALDH1A3,MGST1,UGT1A6,ADH6,CYP2F1,CYP2S1,UGT2B28,AKR7A3,AKR1C1,UGT2A1,MGST2,UGT2B4,CYP2B6,CBR1,ALDH3A1,ADH4,HPGDS,CYP1B1,UGT1A9,CYP2A6,CBR3,ADH7,SULT2A1,ALDH3B1,GSTM1,UGT1A5,UGT1A7,UGT1A8,GSTA1,GSTP1,DHDH,UGT2B11,EPHX1,UGT1A3,UGT2B15,GSTK1,GSTM4,UGT1A4,GSTA3,ALDH3B2,CYP3A5,ADH1C,UGT1A10,CYP1A2,CYP3A4,HSD11B1
ko00980	Metabolism of xenobiotics by cytochrome P450	0.0511432088535369	-2.97312556463593	73	69	0.010952380952381	6300	7161	54575,126,1544,1576,3290,54659,7366,373156,54657,2940,2948,222,1577,2950,2052,10720,27294,54579,54577,2938,54576,874,131,6822,221,2944,218,127,27306,1545,54600,1548,4258,7363,1555,873,29785,1572,54490,22977,1645,10941,220,4257,54578,130,1565,2952,2953,54658,7364,128,4259,574537,1559,119391,2949,125,221357,1543,2941,79799,1553,2939,2946,7365,9446,124,2947	UGT1A10,ADH1C,CYP1A2,CYP3A4,HSD11B1,UGT1A3,UGT2B15,GSTK1,UGT1A4,GSTA3,GSTM4,ALDH3B2,CYP3A5,GSTP1,EPHX1,UGT2B11,DHDH,UGT1A5,UGT1A7,GSTA1,UGT1A8,CBR3,ADH7,SULT2A1,ALDH3B1,GSTM1,ALDH3A1,ADH4,HPGDS,CYP1B1,UGT1A9,CYP2A6,MGST2,UGT2B4,CYP2B6,CBR1,CYP2S1,CYP2F1,UGT2B28,AKR7A3,AKR1C1,UGT2A1,ALDH1A3,MGST1,UGT1A6,ADH6,CYP2D6,GSTT1,GSTT2,UGT1A1,UGT2B7,ADH5,MGST3,UGT2A2,CYP2C9,GSTO2,GSTM5,ADH1B,GSTA5,CYP1A1,GSTA4,UGT2A3,CYP2A13,GSTA2,GSTM2,UGT2B10,GSTO1,ADH1A,GSTM3
hsa04960	Aldosterone-regulated sodium reabsorption	0.0525226595800113	-2.94651059145398	37	36	0.00571428571428571	6300	7161	5579,2810,481,3479,476,9351,6446,5594,8503,5296,5170,5291,4306,3758,3291,483,478,5582,6337,23327,3643,480,5578,5595,477,6338,482,3667,5293,53828,5295,5290,486,3630,6340,3845	PRKCB,SFN,ATP1B1,IGF1,ATP1A1,NHERF2,SGK1,MAPK1,PIK3R3,PIK3R2,PDPK1,PIK3CB,NR3C2,KCNJ1,HSD11B2,ATP1B3,ATP1A3,PRKCG,SCNN1A,NEDD4L,INSR,ATP1A4,PRKCA,MAPK3,ATP1A2,SCNN1B,ATP1B2,IRS1,PIK3CD,FXYD4,PIK3R1,PIK3CA,FXYD2,INS,SCNN1G,KRAS
ko04960	Aldosterone-regulated sodium reabsorption	0.0525226595800113	-2.94651059145398	37	36	0.00571428571428571	6300	7161	6337,478,483,3291,5582,3758,4306,5170,5291,5296,9351,6446,8503,5594,5579,476,2810,481,3479,3845,6340,3630,5293,53828,486,5290,5295,477,5595,5578,3667,6338,482,480,23327,3643	SCNN1A,ATP1A3,ATP1B3,HSD11B2,PRKCG,KCNJ1,NR3C2,PDPK1,PIK3CB,PIK3R2,NHERF2,SGK1,PIK3R3,MAPK1,PRKCB,ATP1A1,SFN,ATP1B1,IGF1,KRAS,SCNN1G,INS,PIK3CD,FXYD4,FXYD2,PIK3CA,PIK3R1,ATP1A2,MAPK3,PRKCA,IRS1,SCNN1B,ATP1B2,ATP1A4,NEDD4L,INSR
ko04520	Adherens junction	0.0553766250502852	-2.89359770476689	72	68	0.0107936507936508	6300	7161	2260,1499,29119,387,3643,5777,998,1459,56288,6714,1457,8936,1496,2241,6934,10810,8826,71,4233,10458,1956,4301,5879,7048,1387,4008,5795,5880,7414,5819,87,81607,10163,81,117178,999,7525,25945,4088,2064,52,10580,5797,2033,4087,6615,5595,7082,8976,5881,4089,7046,5818,1500,2534,5594,6591,60,51176,1495,283106,5770,5792,6932,5787,6885,3480,83439	FGFR1,CTNNB1,CTNNA3,RHOA,INSR,PTPN6,CDC42,CSNK2A2,PARD3,SRC,CSNK2A1,WASF1,CTNNA2,FER,TCF7L2,WASF3,IQGAP1,ACTG1,MET,BAIAP2,EGFR,AFDN,RAC1,TGFBR2,CREBBP,LMO7,PTPRJ,RAC2,VCL,NECTIN2,ACTN1,NECTIN4,WASF2,ACTN4,SSX2IP,CDH1,YES1,NECTIN3,SMAD3,ERBB2,ACP1,SORBS1,PTPRM,EP300,SMAD2,SNAI1,MAPK3,TJP1,WASL,RAC3,SMAD4,TGFBR1,NECTIN1,CTNND1,FYN,MAPK1,SNAI2,ACTB,LEF1,CTNNA1,CSNK2A3,PTPN1,PTPRF,TCF7,PTPRB,MAP3K7,IGF1R,TCF7L1
hsa04520	Adherens junction	0.0553766250502852	-2.89359770476689	72	68	0.0107936507936508	6300	7161	4233,71,1956,10458,5879,4301,7048,1387,5880,5795,4008,5819,7414,10163,81607,87,81,999,7525,117178,25945,4088,1499,29119,2260,387,5777,3643,998,56288,1459,6714,8936,1457,1496,2241,6934,10810,8826,5594,6591,60,51176,1495,283106,5770,5792,5787,6932,6885,83439,3480,52,2064,10580,2033,5797,4087,5595,7082,6615,8976,5881,7046,4089,1500,5818,2534	MET,ACTG1,EGFR,BAIAP2,RAC1,AFDN,TGFBR2,CREBBP,RAC2,PTPRJ,LMO7,NECTIN2,VCL,WASF2,NECTIN4,ACTN1,ACTN4,CDH1,YES1,SSX2IP,NECTIN3,SMAD3,CTNNB1,CTNNA3,FGFR1,RHOA,PTPN6,INSR,CDC42,PARD3,CSNK2A2,SRC,WASF1,CSNK2A1,CTNNA2,FER,TCF7L2,WASF3,IQGAP1,MAPK1,SNAI2,ACTB,LEF1,CTNNA1,CSNK2A3,PTPN1,PTPRF,PTPRB,TCF7,MAP3K7,TCF7L1,IGF1R,ACP1,ERBB2,SORBS1,EP300,PTPRM,SMAD2,MAPK3,TJP1,SNAI1,WASL,RAC3,TGFBR1,SMAD4,CTNND1,NECTIN1,FYN
ko04670	Leukocyte transendothelial migration	0.0581803960867336	-2.84420681798477	114	106	0.0168253968253968	6300	7161	83700,7852,6387,5335,7430,10627,137075,3702,58498,90952,4688,1500,5290,5747,5781,100132463,3688,51208,93408,7294,1366,7408,26285,9475,3689,9080,387,1365,1499,29119,10686,5293,50508,7409,2771,1364,4633,1432,653361,3683,5906,3383,103910,399,5336,9073,81,6300,4689,7414,3684,2770,5908,7412,49861,10451,10398,5295,1003,3676,1495,4313,60,1535,5579,23562,5010,5600,7070,24146,5175,5578,2773,998,9076,100506658,50848,7122,9564,7410,5829,644672,4636,2909,1496,9071,394,5296,4318,5879,4301,149461,6494,11069,5603,58494,8503,71,10411,2185,5582,87,5880,53842,83593,5291	JAM3,CXCR4,CXCL12,PLCG1,EZR,MYL12A,CLDN23,ITK,MYL7,ESAM,NCF2,CTNND1,PIK3CA,PTK2,PTPN11,CLDN24,ITGB1,CLDN18,MYL10,TXK,CLDN7,VASP,CLDN17,ROCK2,ITGB2,CLDN9,RHOA,CLDN3,CTNNB1,CTNNA3,CLDN16,PIK3CD,NOX3,VAV1,GNAI2,CLDN4,MYL2,MAPK14,NCF1,ITGAL,RAP1A,ICAM1,MYL12B,RHOH,PLCG2,CLDN8,ACTN4,MAPK12,NCF4,VCL,ITGAM,GNAI1,RAP1B,VCAM1,CLDN20,VAV3,MYL9,PIK3R1,CDH5,ITGA4,CTNNA1,MMP2,ACTB,CYBA,PRKCB,CLDN14,CLDN11,MAPK11,THY1,CLDN15,PECAM1,PRKCA,GNAI3,CDC42,CLDN1,OCLN,F11R,CLDN5,BCAR1,VAV2,PXN,CLDN25,MYL5,ARHGAP35,CTNNA2,CLDN10,ARHGAP5,PIK3R2,MMP9,RAC1,AFDN,CLDN19,SIPA1,RAPGEF4,MAPK13,JAM2,PIK3R3,ACTG1,RAPGEF3,PTK2B,PRKCG,ACTN1,RAC2,CLDN22,RASSF5,PIK3CB
hsa04670	Leukocyte transendothelial migration	0.0581803960867336	-2.84420681798477	114	106	0.0168253968253968	6300	7161	7294,93408,1366,7408,26285,5781,3688,51208,100132463,90952,58498,4688,1500,5290,5747,83700,6387,7852,7430,10627,5335,3702,137075,5906,399,5336,103910,3383,9073,81,4689,7414,6300,1432,2771,1364,4633,653361,3683,50508,5293,7409,9475,3689,1365,9080,387,10686,1499,29119,7070,5175,24146,1003,3676,4313,1495,60,1535,5579,5010,5600,23562,7412,10398,49861,10451,5295,3684,2770,5908,2185,5582,10411,87,83593,5291,53842,5880,394,5296,5879,4318,4301,11069,149461,6494,8503,58494,71,5603,7410,5829,644672,1496,4636,2909,9071,2773,5578,100506658,9076,998,50848,7122,9564	TXK,MYL10,CLDN7,VASP,CLDN17,PTPN11,ITGB1,CLDN18,CLDN24,ESAM,MYL7,NCF2,CTNND1,PIK3CA,PTK2,JAM3,CXCL12,CXCR4,EZR,MYL12A,PLCG1,ITK,CLDN23,RAP1A,RHOH,PLCG2,MYL12B,ICAM1,CLDN8,ACTN4,NCF4,VCL,MAPK12,MAPK14,GNAI2,CLDN4,MYL2,NCF1,ITGAL,NOX3,PIK3CD,VAV1,ROCK2,ITGB2,CLDN3,CLDN9,RHOA,CLDN16,CTNNB1,CTNNA3,THY1,PECAM1,CLDN15,CDH5,ITGA4,MMP2,CTNNA1,ACTB,CYBA,PRKCB,CLDN11,MAPK11,CLDN14,VCAM1,MYL9,CLDN20,VAV3,PIK3R1,ITGAM,GNAI1,RAP1B,PTK2B,PRKCG,RAPGEF3,ACTN1,RASSF5,PIK3CB,CLDN22,RAC2,ARHGAP5,PIK3R2,RAC1,MMP9,AFDN,RAPGEF4,CLDN19,SIPA1,PIK3R3,JAM2,ACTG1,MAPK13,VAV2,PXN,CLDN25,CTNNA2,MYL5,ARHGAP35,CLDN10,GNAI3,PRKCA,OCLN,CLDN1,CDC42,F11R,CLDN5,BCAR1
ko05210	Colorectal cancer	0.0587756212289424	-2.83402811499991	60	57	0.00904761904761905	6300	7161	5594,51176,7042,842,7043,332,1630,10297,6932,836,10000,26060,83439,208,5900,4087,5604,5595,3725,8312,7157,8313,5881,54205,5295,4089,7046,5290,596,5602,8503,4292,5599,5296,7040,7048,5879,5894,5880,2956,673,5291,2353,595,4609,4088,1499,2932,324,387,5601,4436,207,581,5293,3845,6934	MAPK1,LEF1,TGFB2,CASP9,TGFB3,BIRC5,DCC,APC2,TCF7,CASP3,AKT3,APPL1,TCF7L1,AKT2,RALGDS,SMAD2,MAP2K1,MAPK3,JUN,AXIN1,TP53,AXIN2,RAC3,CYCS,PIK3R1,SMAD4,TGFBR1,PIK3CA,BCL2,MAPK10,PIK3R3,MLH1,MAPK8,PIK3R2,TGFB1,TGFBR2,RAC1,RAF1,RAC2,MSH6,BRAF,PIK3CB,FOS,CCND1,MYC,SMAD3,CTNNB1,GSK3B,APC,RHOA,MAPK9,MSH2,AKT1,BAX,PIK3CD,KRAS,TCF7L2
hsa05210	Colorectal cancer	0.0587756212289424	-2.83402811499991	60	57	0.00904761904761905	6300	7161	5290,5295,7046,4089,54205,5881,596,5900,7157,8313,8312,3725,5604,5595,4087,10000,836,6932,10297,1630,332,208,83439,26060,51176,5594,7043,842,7042,5293,581,6934,3845,5601,387,324,2932,1499,207,4436,2353,5291,673,2956,5880,4088,4609,595,5599,8503,4292,5602,5894,7040,7048,5879,5296	PIK3CA,PIK3R1,TGFBR1,SMAD4,CYCS,RAC3,BCL2,RALGDS,TP53,AXIN2,AXIN1,JUN,MAP2K1,MAPK3,SMAD2,AKT3,CASP3,TCF7,APC2,DCC,BIRC5,AKT2,TCF7L1,APPL1,LEF1,MAPK1,TGFB3,CASP9,TGFB2,PIK3CD,BAX,TCF7L2,KRAS,MAPK9,RHOA,APC,GSK3B,CTNNB1,AKT1,MSH2,FOS,PIK3CB,BRAF,MSH6,RAC2,SMAD3,MYC,CCND1,MAPK8,PIK3R3,MLH1,MAPK10,RAF1,TGFB1,TGFBR2,RAC1,PIK3R2
hsa05220	Chronic myeloid leukemia	0.0599239420756547	-2.81467915295762	71	67	0.0106349206349206	6300	7161	1147,208,10000,4893,7043,7042,1870,1398,5605,5594,53358,25,5781,9846,1488,861,3065,5290,7046,5295,4089,7157,6464,6777,25759,5595,5604,4193,6776,867,4792,595,4088,5970,2122,4609,613,3265,5291,673,6654,868,3551,1869,7040,7048,399694,5296,5894,1487,1019,3066,8503,6655,3845,1026,1027,5293,1029,207,5925,23624,2885,1871,4790,1021,598	CHUK,AKT2,AKT3,NRAS,TGFB3,TGFB2,E2F2,CRK,MAP2K2,MAPK1,SHC3,ABL1,PTPN11,GAB2,CTBP2,RUNX1,HDAC1,PIK3CA,TGFBR1,PIK3R1,SMAD4,TP53,SHC1,STAT5B,SHC2,MAPK3,MAP2K1,MDM2,STAT5A,CBL,NFKBIA,CCND1,SMAD3,RELA,MECOM,MYC,BCR,HRAS,PIK3CB,BRAF,SOS1,CBLB,IKBKB,E2F1,TGFB1,TGFBR2,SHC4,PIK3R2,RAF1,CTBP1,CDK4,HDAC2,PIK3R3,SOS2,KRAS,CDKN1A,CDKN1B,PIK3CD,CDKN2A,AKT1,RB1,CBLC,GRB2,E2F3,NFKB1,CDK6,BCL2L1
ko05220	Chronic myeloid leukemia	0.0599239420756547	-2.81467915295762	71	67	0.0106349206349206	6300	7161	1147,208,4893,10000,1870,7042,7043,1398,5594,5605,9846,5781,25,53358,1488,3065,861,7046,5295,4089,5290,5595,5604,6777,25759,6464,7157,4792,867,6776,4193,595,4609,2122,4088,5970,673,5291,3265,613,868,6654,5296,399694,7040,7048,3551,1869,5894,1487,8503,3066,1019,3845,6655,1026,5293,1027,1029,1871,2885,5925,23624,207,598,1021,4790	CHUK,AKT2,NRAS,AKT3,E2F2,TGFB2,TGFB3,CRK,MAPK1,MAP2K2,GAB2,PTPN11,ABL1,SHC3,CTBP2,HDAC1,RUNX1,TGFBR1,PIK3R1,SMAD4,PIK3CA,MAPK3,MAP2K1,STAT5B,SHC2,SHC1,TP53,NFKBIA,CBL,STAT5A,MDM2,CCND1,MYC,MECOM,SMAD3,RELA,BRAF,PIK3CB,HRAS,BCR,CBLB,SOS1,PIK3R2,SHC4,TGFB1,TGFBR2,IKBKB,E2F1,RAF1,CTBP1,PIK3R3,HDAC2,CDK4,KRAS,SOS2,CDKN1A,PIK3CD,CDKN1B,CDKN2A,E2F3,GRB2,RB1,CBLC,AKT1,BCL2L1,CDK6,NFKB1
ko05032	Morphine addiction	0.0671073545312514	-2.70146163547794	91	85	0.0134920634920635	6300	7161	94235,2565,107,2568,2560,2559,3763,3762,140679,2784,2790,5578,2773,2557,5144,111,2788,2869,5150,5582,59345,134,2570,1812,5138,2771,9568,10681,5140,5568,112,54331,115,2562,5566,2563,109,5151,5139,3760,3765,27115,2868,113,51764,5567,2554,5136,2778,2770,50940,2793,2792,2787,5137,156,409,114,5141,2786,2558,2550,2555,5153,2870,773,2782,2561,2783,8622,4988,408,10846,200959,2569,2567,157,2791,108,2566,5579,5143,5142,55970,196883	GNG8,GABRG1,ADCY1,GABRP,GABRB1,GABRA6,KCNJ6,KCNJ5,SLC32A1,GNB3,GNG10,PRKCA,GNAI3,GABRA4,PDE4D,ADCY5,GNG7,GRK5,PDE7A,PRKCG,GNB4,ADORA1,GABRR2,DRD1,PDE2A,GNAI2,GABBR2,GNB5,PDE3B,PRKACG,ADCY6,GNG2,ADCY9,GABRB3,PRKACA,GABRD,ADCY3,PDE8A,PDE3A,KCNJ3,KCNJ9,PDE7B,GRK4,ADCY7,GNG13,PRKACB,GABRA1,PDE1A,GNAS,GNAI1,PDE11A,GNGT2,GNGT1,GNG5,PDE1C,GRK2,ARRB2,ADCY8,PDE4A,GNG4,GABRA5,GABBR1,GABRA2,PDE1B,GRK6,CACNA1A,GNB1,GABRB2,GNB2,PDE8B,OPRM1,ARRB1,PDE10A,GABRR3,GABRR1,GABRG3,GRK3,GNG11,ADCY2,GABRG2,PRKCB,PDE4C,PDE4B,GNG12,ADCY4
hsa05032	Morphine addiction	0.0671073545312514	-2.70146163547794	91	85	0.0134920634920635	6300	7161	94235,107,2560,2568,2565,2559,3762,3763,140679,2784,2790,5578,2773,5144,111,2557,2788,5582,5150,2869,59345,2570,1812,134,5138,2771,9568,10681,5140,5568,112,54331,115,5566,2563,2562,5139,109,5151,3765,3760,27115,2868,5567,113,51764,2554,2770,5136,2778,2792,2793,50940,2787,409,156,5137,114,5141,2786,773,2555,5153,2870,2550,2558,2783,8622,2561,2782,4988,408,10846,200959,2569,2567,157,2791,108,5579,2566,5142,5143,196883,55970	GNG8,ADCY1,GABRB1,GABRP,GABRG1,GABRA6,KCNJ5,KCNJ6,SLC32A1,GNB3,GNG10,PRKCA,GNAI3,PDE4D,ADCY5,GABRA4,GNG7,PRKCG,PDE7A,GRK5,GNB4,GABRR2,DRD1,ADORA1,PDE2A,GNAI2,GABBR2,GNB5,PDE3B,PRKACG,ADCY6,GNG2,ADCY9,PRKACA,GABRD,GABRB3,PDE3A,ADCY3,PDE8A,KCNJ9,KCNJ3,PDE7B,GRK4,PRKACB,ADCY7,GNG13,GABRA1,GNAI1,PDE1A,GNAS,GNGT1,GNGT2,PDE11A,GNG5,ARRB2,GRK2,PDE1C,ADCY8,PDE4A,GNG4,CACNA1A,GABRA2,PDE1B,GRK6,GABBR1,GABRA5,GNB2,PDE8B,GABRB2,GNB1,OPRM1,ARRB1,PDE10A,GABRR3,GABRR1,GABRG3,GRK3,GNG11,ADCY2,PRKCB,GABRG2,PDE4B,PDE4C,ADCY4,GNG12
hsa05223	Non-small cell lung cancer	0.0695587568284394	-2.66558346158734	58	55	0.00873015873015873	6300	7161	5170,4893,10000,208,5605,5594,3718,5579,1870,2272,842,6256,5290,5295,7039,1950,2064,5335,6776,6777,5604,5595,7157,673,3265,5291,83593,6654,595,11186,5336,5582,27436,6789,8503,1019,5915,1956,5296,1869,2309,5894,6258,5293,6774,3845,6655,238,1021,1029,5925,2885,1871,5578,207	PDPK1,NRAS,AKT3,AKT2,MAP2K2,MAPK1,JAK3,PRKCB,E2F2,FHIT,CASP9,RXRA,PIK3CA,PIK3R1,TGFA,EGF,ERBB2,PLCG1,STAT5A,STAT5B,MAP2K1,MAPK3,TP53,BRAF,HRAS,PIK3CB,RASSF5,SOS1,CCND1,RASSF1,PLCG2,PRKCG,EML4,STK4,PIK3R3,CDK4,RARB,EGFR,PIK3R2,E2F1,FOXO3,RAF1,RXRG,PIK3CD,STAT3,KRAS,SOS2,ALK,CDK6,CDKN2A,RB1,GRB2,E2F3,PRKCA,AKT1
ko05223	Non-small cell lung cancer	0.0695587568284394	-2.66558346158734	58	55	0.00873015873015873	6300	7161	5295,7039,5290,1950,2064,5335,6776,5595,6777,5604,7157,5170,4893,10000,208,5594,5605,3718,5579,2272,1870,842,6256,6258,5293,6774,3845,6655,238,1021,1029,5578,1871,2885,5925,207,673,5291,83593,3265,6654,11186,595,5336,5582,27436,8503,1019,6789,1956,5915,5296,1869,2309,5894	PIK3R1,TGFA,PIK3CA,EGF,ERBB2,PLCG1,STAT5A,MAPK3,STAT5B,MAP2K1,TP53,PDPK1,NRAS,AKT3,AKT2,MAPK1,MAP2K2,JAK3,PRKCB,FHIT,E2F2,CASP9,RXRA,RXRG,PIK3CD,STAT3,KRAS,SOS2,ALK,CDK6,CDKN2A,PRKCA,E2F3,GRB2,RB1,AKT1,BRAF,PIK3CB,RASSF5,HRAS,SOS1,RASSF1,CCND1,PLCG2,PRKCG,EML4,PIK3R3,CDK4,STK4,EGFR,RARB,PIK3R2,E2F1,FOXO3,RAF1
hsa05218	Melanoma	0.0700375024277035	-2.65872443142783	69	65	0.0103174603174603	6300	7161	5159,5295,5290,1950,3082,8074,4193,5156,5728,5604,5595,26281,7157,2254,27006,4893,10000,56034,2248,208,3480,3479,2250,2255,5605,5594,1870,2249,5293,80310,2257,5154,1026,3845,9965,2256,1021,2260,2246,2251,1871,5925,207,2259,1029,2247,673,5291,3265,5155,8817,999,595,2253,1956,26291,2252,8822,8503,4233,1019,5894,4286,5296,1869	PDGFRB,PIK3R1,PIK3CA,EGF,HGF,FGF23,MDM2,PDGFRA,PTEN,MAP2K1,MAPK3,FGF20,TP53,FGF9,FGF22,NRAS,AKT3,PDGFC,FGF3,AKT2,IGF1R,IGF1,FGF5,FGF10,MAP2K2,MAPK1,E2F2,FGF4,PIK3CD,PDGFD,FGF12,PDGFA,CDKN1A,KRAS,FGF19,FGF11,CDK6,FGFR1,FGF1,FGF6,E2F3,RB1,AKT1,FGF14,CDKN2A,FGF2,BRAF,PIK3CB,HRAS,PDGFB,FGF18,CDH1,CCND1,FGF8,EGFR,FGF21,FGF7,FGF17,PIK3R3,MET,CDK4,RAF1,MITF,PIK3R2,E2F1
ko05218	Melanoma	0.0700375024277035	-2.65872443142783	69	65	0.0103174603174603	6300	7161	2260,2246,2251,1021,1029,2247,1871,5925,207,2259,5154,2257,2249,5293,80310,9965,3845,2256,1026,8503,1019,8822,4233,1956,2253,26291,2252,5296,1869,5894,4286,673,5291,3265,999,595,5155,8817,5156,5728,8074,3082,4193,2254,27006,5604,5595,26281,7157,5295,5159,5290,1950,5605,5594,2250,3479,2255,1870,4893,10000,56034,2248,208,3480	FGFR1,FGF1,FGF6,CDK6,CDKN2A,FGF2,E2F3,RB1,AKT1,FGF14,PDGFA,FGF12,FGF4,PIK3CD,PDGFD,FGF19,KRAS,FGF11,CDKN1A,PIK3R3,CDK4,FGF17,MET,EGFR,FGF8,FGF21,FGF7,PIK3R2,E2F1,RAF1,MITF,BRAF,PIK3CB,HRAS,CDH1,CCND1,PDGFB,FGF18,PDGFRA,PTEN,FGF23,HGF,MDM2,FGF9,FGF22,MAP2K1,MAPK3,FGF20,TP53,PIK3R1,PDGFRB,PIK3CA,EGF,MAP2K2,MAPK1,FGF5,IGF1,FGF10,E2F2,NRAS,AKT3,PDGFC,FGF3,AKT2,IGF1R
ko05160	Hepatitis C	0.0712818315251769	-2.64111380135203	131	121	0.0192063492063492	6300	7161	148022,9073,3659,6300,673,3441,1965,3665,3646,9451,29110,3439,4939,5894,1364,1432,5293,5518,1026,3845,3716,10379,9080,5610,5601,1365,4790,3452,10686,2885,439996,207,8717,4893,3444,10000,26285,5170,8554,5519,208,1366,6773,6772,1147,440275,100132463,5594,51208,6256,7124,5290,10197,3661,3445,5521,1950,4792,137075,5595,4938,6654,3449,53842,5291,3265,27102,3456,7098,5970,5520,10062,5599,1956,149461,7297,5602,5603,9021,8503,9641,5296,3551,5465,6774,5515,9071,3442,3443,644672,6655,7122,949,6041,2932,23586,3949,9076,100506658,7132,24146,7187,5522,3576,975,3434,23562,5010,5600,7189,3454,5516,8737,5295,4940,49861,3440,3448,57506,3455,7157	TICAM1,CLDN8,IRF1,MAPK12,BRAF,IFNA4,EIF2S1,IRF7,EIF3E,EIF2AK3,TBK1,IFNA1,OAS2,RAF1,CLDN4,MAPK14,PIK3CD,PPP2R1A,CDKN1A,KRAS,JAK1,IRF9,CLDN9,EIF2AK2,MAPK9,CLDN3,NFKB1,IFNA21,CLDN16,GRB2,IFIT1B,AKT1,TRADD,NRAS,IFNA7,AKT3,CLDN17,PDPK1,PIAS1,PPP2R1B,AKT2,CLDN7,STAT2,STAT1,CHUK,EIF2AK4,CLDN24,MAPK1,CLDN18,RXRA,TNF,PIK3CA,PSME3,IRF3,IFNA8,PPP2R2B,EGF,NFKBIA,CLDN23,MAPK3,OAS1,SOS1,IFNA16,CLDN22,PIK3CB,HRAS,EIF2AK1,IFNB1,TLR3,RELA,PPP2R2A,NR1H3,MAPK8,EGFR,CLDN19,TYK2,MAPK10,MAPK13,SOCS3,PIK3R3,IKBKE,PIK3R2,IKBKB,PPARA,STAT3,PPP2CA,CLDN10,IFNA5,IFNA6,CLDN25,SOS2,CLDN5,SCARB1,RNASEL,GSK3B,RIGI,LDLR,CLDN1,OCLN,TNFRSF1A,CLDN15,TRAF3,PPP2R2C,CXCL8,CD81,IFIT1,CLDN14,CLDN11,MAPK11,TRAF6,IFNAR1,PPP2CB,RIPK1,PIK3R1,OAS3,CLDN20,IFNA2,IFNA14,MAVS,IFNAR2,TP53
hsa05160	Hepatitis C	0.0712818315251769	-2.64111380135203	131	121	0.0192063492063492	6300	7161	8717,207,439996,2885,4790,1365,5601,5610,9080,10686,3452,1026,10379,3716,3845,5518,5293,5894,1432,1364,3439,29110,9451,4939,1965,3441,3646,3665,3659,9073,148022,673,6300,5595,4938,4792,137075,3661,10197,1950,5521,3445,5290,6256,7124,440275,51208,5594,100132463,208,5519,8554,1147,6772,6773,1366,10000,26285,3444,4893,5170,3949,23586,9076,100506658,949,7122,2932,6041,3443,6655,644672,3442,5515,6774,9071,3551,5465,5296,7297,149461,5599,1956,9641,9021,8503,5603,5602,5520,5970,7098,27102,3456,10062,6654,3265,5291,3449,53842,7157,57506,3455,4940,3440,3448,49861,5295,8737,7189,3454,5516,5600,5010,23562,3434,3576,5522,975,7132,7187,24146	TRADD,AKT1,IFIT1B,GRB2,NFKB1,CLDN3,MAPK9,EIF2AK2,CLDN9,CLDN16,IFNA21,CDKN1A,IRF9,JAK1,KRAS,PPP2R1A,PIK3CD,RAF1,MAPK14,CLDN4,IFNA1,TBK1,EIF2AK3,OAS2,EIF2S1,IFNA4,EIF3E,IRF7,IRF1,CLDN8,TICAM1,BRAF,MAPK12,MAPK3,OAS1,NFKBIA,CLDN23,IRF3,PSME3,EGF,PPP2R2B,IFNA8,PIK3CA,RXRA,TNF,EIF2AK4,CLDN18,MAPK1,CLDN24,AKT2,PPP2R1B,PIAS1,CHUK,STAT1,STAT2,CLDN7,AKT3,CLDN17,IFNA7,NRAS,PDPK1,LDLR,RIGI,CLDN1,OCLN,SCARB1,CLDN5,GSK3B,RNASEL,IFNA6,SOS2,CLDN25,IFNA5,PPP2CA,STAT3,CLDN10,IKBKB,PPARA,PIK3R2,TYK2,CLDN19,MAPK8,EGFR,IKBKE,SOCS3,PIK3R3,MAPK13,MAPK10,PPP2R2A,RELA,TLR3,EIF2AK1,IFNB1,NR1H3,SOS1,HRAS,PIK3CB,IFNA16,CLDN22,TP53,MAVS,IFNAR2,OAS3,IFNA2,IFNA14,CLDN20,PIK3R1,RIPK1,TRAF6,IFNAR1,PPP2CB,MAPK11,CLDN11,CLDN14,IFIT1,CXCL8,PPP2R2C,CD81,TNFRSF1A,TRAF3,CLDN15
hsa00040	Pentose and glucuronate interconversions	0.0720241850096906	-2.63075331345646	34	33	0.00523809523809524	6300	7161	54575,54578,6652,54659,7366,54657,57016,51084,7358,729920,27294,10720,6120,54658,54579,7364,54577,574537,54576,2990,51181,54600,79799,10327,7363,7360,231,7365,9942,54490,729020,9365,10941	UGT1A10,UGT1A6,SORD,UGT1A3,UGT2B15,UGT1A4,AKR1B10,CRYL1,UGDH,CRPPA,DHDH,UGT2B11,RPE,UGT1A1,UGT1A5,UGT2B7,UGT1A7,UGT2A2,UGT1A8,GUSB,DCXR,UGT1A9,UGT2A3,AKR1A1,UGT2B4,UGP2,AKR1B1,UGT2B10,XYLB,UGT2B28,RPEL1,KL,UGT2A1
ko00040	Pentose and glucuronate interconversions	0.0720241850096906	-2.63075331345646	34	33	0.00523809523809524	6300	7161	51181,54600,79799,10327,7360,7365,231,7363,729020,54490,9942,10941,9365,54575,54578,6652,54657,54659,7366,51084,57016,729920,7358,54658,10720,27294,6120,54577,574537,54579,7364,54576,2990	DCXR,UGT1A9,UGT2A3,AKR1A1,UGP2,UGT2B10,AKR1B1,UGT2B4,RPEL1,UGT2B28,XYLB,UGT2A1,KL,UGT1A10,UGT1A6,SORD,UGT1A4,UGT1A3,UGT2B15,CRYL1,AKR1B10,CRPPA,UGDH,UGT1A1,UGT2B11,DHDH,RPE,UGT1A7,UGT2A2,UGT1A5,UGT2B7,UGT1A8,GUSB
hsa05143	African trypanosomiasis	0.0720241850096906	-2.63075331345646	34	33	0.00523809523809524	6300	7161	7124,3910,5579,3620,5331,54106,3043,356,5582,3383,7064,23236,4615,2776,335,5578,3586,3553,8542,5330,355,5332,3592,169355,3593,3569,2150,3458,3039,7412,3250,6401,3606	TNF,LAMA4,PRKCB,IDO1,PLCB3,TLR9,HBB,FASLG,PRKCG,ICAM1,THOP1,PLCB1,MYD88,GNAQ,APOA1,PRKCA,IL10,IL1B,APOL1,PLCB2,FAS,PLCB4,IL12A,IDO2,IL12B,IL6,F2RL1,IFNG,HBA1,VCAM1,HPR,SELE,IL18
ko05143	African trypanosomiasis	0.0720241850096906	-2.63075331345646	34	33	0.00523809523809524	6300	7161	5332,5330,355,3458,2150,3569,3593,169355,3592,3586,3553,335,5578,8542,3250,3606,6401,7412,3039,5579,356,3043,54106,5331,3620,3910,7124,2776,4615,23236,5582,7064,3383	PLCB4,PLCB2,FAS,IFNG,F2RL1,IL6,IL12B,IDO2,IL12A,IL10,IL1B,APOA1,PRKCA,APOL1,HPR,IL18,SELE,VCAM1,HBA1,PRKCB,FASLG,HBB,TLR9,PLCB3,IDO1,LAMA4,TNF,GNAQ,MYD88,PLCB1,PRKCG,THOP1,ICAM1
ko04930	Type II diabetes mellitus	0.0728248402180125	-2.61969817019311	46	44	0.00698412698412698	6300	7161	8913,3098,2645,775,6514,5291,5580,777,2475,773,3651,5599,8660,3101,8651,5602,8503,3767,9021,5594,7124,5296,3551,6517,5293,5295,5290,776,122809,3630,8835,5313,5315,3099,5581,5601,80201,3643,5595,5590,3667,6833,9370,389692	CACNA1G,HK1,GCK,CACNA1C,SLC2A2,PIK3CB,PRKCD,CACNA1E,MTOR,CACNA1A,PDX1,MAPK8,IRS2,HK3,SOCS1,MAPK10,PIK3R3,KCNJ11,SOCS3,MAPK1,TNF,PIK3R2,IKBKB,SLC2A4,PIK3CD,PIK3R1,PIK3CA,CACNA1D,SOCS4,INS,SOCS2,PKLR,PKM,HK2,PRKCE,MAPK9,HKDC1,INSR,MAPK3,PRKCZ,IRS1,ABCC8,ADIPOQ,MAFA
hsa04930	Type II diabetes mellitus	0.0728248402180125	-2.61969817019311	46	44	0.00698412698412698	6300	7161	5602,8503,9021,3767,8660,5599,8651,5296,6517,3551,5291,3098,3651,777,2475,3643,5601,80201,9370,6833,389692,8835,122809,5293,776,5581,5315,5594,3101,7124,775,6514,8913,2645,773,5580,5590,5595,3667,3630,5290,5295,5313,3099	MAPK10,PIK3R3,SOCS3,KCNJ11,IRS2,MAPK8,SOCS1,PIK3R2,SLC2A4,IKBKB,PIK3CB,HK1,PDX1,CACNA1E,MTOR,INSR,MAPK9,HKDC1,ADIPOQ,ABCC8,MAFA,SOCS2,SOCS4,PIK3CD,CACNA1D,PRKCE,PKM,MAPK1,HK3,TNF,CACNA1C,SLC2A2,CACNA1G,GCK,CACNA1A,PRKCD,PRKCZ,MAPK3,IRS1,INS,PIK3CA,PIK3R1,PKLR,HK2
hsa01521	EGFR tyrosine kinase inhibitor resistance	0.0741867687094777	-2.60116946398885	79	74	0.0117460317460317	6300	7161	5728,2263,2064,3569,5156,5335,3082,6464,25759,5604,5595,5290,5159,7039,6194,5295,1950,3791,596,5594,5605,1977,53358,3479,5579,2261,10018,2065,10000,7422,4893,6198,3480,208,56034,3570,2932,598,2247,207,6714,2549,9470,5578,2885,3717,5154,581,6199,80310,1978,5293,6774,9542,6655,3716,3845,8503,4233,1956,399694,3084,5296,4763,5894,2309,3265,5291,673,6654,5336,5582,5155,2475	PTEN,FGFR2,ERBB2,IL6,PDGFRA,PLCG1,HGF,SHC1,SHC2,MAP2K1,MAPK3,PIK3CA,PDGFRB,TGFA,RPS6,PIK3R1,EGF,KDR,BCL2,MAPK1,MAP2K2,EIF4E,SHC3,IGF1,PRKCB,FGFR3,BCL2L11,ERBB3,AKT3,VEGFA,NRAS,RPS6KB1,IGF1R,AKT2,PDGFC,IL6R,GSK3B,BCL2L1,FGF2,AKT1,SRC,GAB1,EIF4E2,PRKCA,GRB2,JAK2,PDGFA,BAX,RPS6KB2,PDGFD,EIF4EBP1,PIK3CD,STAT3,NRG2,SOS2,JAK1,KRAS,PIK3R3,MET,EGFR,SHC4,NRG1,PIK3R2,NF1,RAF1,FOXO3,HRAS,PIK3CB,BRAF,SOS1,PLCG2,PRKCG,PDGFB,MTOR
ko01521	EGFR tyrosine kinase inhibitor resistance	0.0741867687094777	-2.60116946398885	79	74	0.0117460317460317	6300	7161	1950,3791,596,5290,5159,5295,7039,6194,5604,5595,25759,6464,2064,3569,5156,5728,2263,5335,3082,6198,56034,208,3480,4893,7422,10000,10018,2065,1977,5605,5594,5579,2261,53358,3479,3845,6655,3716,5154,581,6199,3717,6774,5293,9542,80310,1978,2247,9470,2885,5578,207,2549,6714,2932,3570,598,5336,2475,5582,5155,673,3265,5291,6654,3084,399694,5296,4763,2309,5894,8503,4233,1956	EGF,KDR,BCL2,PIK3CA,PDGFRB,PIK3R1,TGFA,RPS6,MAP2K1,MAPK3,SHC2,SHC1,ERBB2,IL6,PDGFRA,PTEN,FGFR2,PLCG1,HGF,RPS6KB1,PDGFC,AKT2,IGF1R,NRAS,VEGFA,AKT3,BCL2L11,ERBB3,EIF4E,MAP2K2,MAPK1,PRKCB,FGFR3,SHC3,IGF1,KRAS,SOS2,JAK1,PDGFA,BAX,RPS6KB2,JAK2,STAT3,PIK3CD,NRG2,PDGFD,EIF4EBP1,FGF2,EIF4E2,GRB2,PRKCA,AKT1,GAB1,SRC,GSK3B,IL6R,BCL2L1,PLCG2,MTOR,PRKCG,PDGFB,BRAF,HRAS,PIK3CB,SOS1,NRG1,SHC4,PIK3R2,NF1,FOXO3,RAF1,PIK3R3,MET,EGFR
M00679	BMP signaling	0.0768704898208233	-2.56563322357397	20	20	0.00317460317460317	6300	7161	268,654,8200,658,652,93,650,4089,269,657,653,4093,92,659,4090,4086,655,90,353500,656	AMH,BMP6,GDF5,BMPR1B,BMP4,ACVR2B,BMP2,SMAD4,AMHR2,BMPR1A,BMP5,SMAD9,ACVR2A,BMPR2,SMAD5,SMAD1,BMP7,ACVR1,BMP8A,BMP8B
hsa_M00679	BMP signaling	0.0768704898208233	-2.56563322357397	20	20	0.00317460317460317	6300	7161	268,654,8200,652,93,658,650,4089,269,4090,653,657,659,4093,92,90,4086,655,656,353500	AMH,BMP6,GDF5,BMP4,ACVR2B,BMPR1B,BMP2,SMAD4,AMHR2,SMAD5,BMP5,BMPR1A,BMPR2,SMAD9,ACVR2A,ACVR1,SMAD1,BMP7,BMP8B,BMP8A
hsa04621	NOD-like receptor signaling pathway	0.0769197866881136	-2.56499213143085	169	155	0.0246031746031746	6300	7161	7295,222545,2921,10454,51393,1508,3445,54822,596,7226,3661,841,6352,4792,4793,4938,2634,51135,5595,846,2919,3444,1147,6773,6772,5594,7416,90550,2635,171389,7124,3709,7205,24145,340061,10392,50508,3716,10379,10628,199713,11035,3708,3452,5601,4790,387,152138,100506742,834,3553,6300,4615,820,148022,29108,4210,3665,3320,8767,330,5027,3428,3441,9474,4939,5331,3439,29110,55669,260434,59082,1432,115362,118429,9447,10059,11345,7099,8737,84168,3448,3440,4940,9051,837,3455,91662,3569,3326,7128,5330,56919,57506,58484,440068,4671,3725,7187,9927,388646,55914,7419,22861,6885,5580,3576,5600,10616,1535,23118,3710,7417,6347,3454,7189,10135,64127,84674,329,3606,10010,3442,3443,6041,5332,7188,598,23710,22900,23236,3449,2920,140609,115361,79792,79671,7158,5970,3456,2633,9641,25828,5602,8772,5603,11337,7297,5599,3551,114548,9140,55054,10910,838	TXN,GPRC6A,CXCL3,TAB1,TRPV2,CTSB,IFNA8,TRPM7,BCL2,TRPM2,IRF3,CASP8,CCL5,NFKBIA,NFKBIB,OAS1,GBP2,IRAK4,MAPK3,CASR,CXCL1,IFNA7,CHUK,STAT2,STAT1,MAPK1,VDAC1,MCU,GBP3,NLRP6,TNF,ITPR2,TRIP6,PANX1,STING1,NOD1,NOX3,JAK1,IRF9,TXNIP,NLRP7,RIPK3,ITPR1,IFNA21,MAPK9,NFKB1,RHOA,PYDC2,CASP12,CASP1,IL1B,MAPK12,MYD88,CAMP,TICAM1,PYCARD,MEFV,IRF7,HSP90AA1,RIPK2,BIRC3,P2RX7,IFI16,IFNA4,ATG5,OAS2,PLCB3,IFNA1,TBK1,MFN1,PYDC1,CARD18,MAPK14,GBP5,ANTXR2,AIM2,DNM1L,GABARAPL2,TLR4,RIPK1,ANTXR1,IFNA14,IFNA2,OAS3,PSTPIP1,CASP4,IFNAR2,NLRP12,IL6,HSP90AB1,TNFAIP3,PLCB2,DHX33,MAVS,NLRC4,CARD17P,NAIP,JUN,TRAF3,MFN2,GBP7,ERBIN,VDAC3,NLRP1,MAP3K7,PRKCD,CXCL8,MAPK11,RBCK1,CYBA,TAB2,ITPR3,VDAC2,CCL2,IFNAR1,TRAF6,NAMPT,NOD2,CARD6,BIRC2,IL18,TANK,IFNA5,IFNA6,RNASEL,PLCB4,TRAF5,BCL2L1,GABARAPL1,CARD8,PLCB1,IFNA16,CXCL2,NEK7,GBP4,GSDMD,NLRX1,TP53BP1,RELA,IFNB1,GBP1,IKBKE,TXN2,MAPK10,FADD,MAPK13,GABARAP,TYK2,MAPK8,IKBKB,NLRP3,ATG12,ATG16L1,SUGT1,CASP5
ko04621	NOD-like receptor signaling pathway	0.0769197866881136	-2.56499213143085	169	155	0.0246031746031746	6300	7161	4792,4793,6352,841,5595,2634,51135,4938,2921,222545,7295,7226,3661,596,3445,54822,10454,51393,1508,171389,2635,90550,5594,7416,24145,7205,7124,3709,3444,2919,846,6773,6772,1147,387,5601,4790,3708,3452,199713,11035,3553,152138,834,100506742,50508,10392,340061,3716,10379,10628,55669,29110,3439,4939,5331,9474,9447,118429,59082,260434,1432,115362,148022,6300,820,4615,3428,3441,5027,8767,330,3665,3320,4210,29108,5330,56919,57506,3326,7128,91662,3569,3455,3725,4671,440068,58484,8737,84168,7099,11345,10059,9051,837,4940,3440,3448,1535,23118,3710,10616,5600,3454,10135,7189,64127,6347,7417,55914,7419,9927,388646,7187,5580,3576,22861,6885,598,7188,23710,5332,6041,329,10010,3606,84674,3442,3443,5599,11337,7297,5602,25828,8772,5603,2633,9641,838,10910,55054,114548,9140,3551,115361,140609,23236,3449,2920,22900,3456,5970,7158,79671,79792	NFKBIA,NFKBIB,CCL5,CASP8,MAPK3,GBP2,IRAK4,OAS1,CXCL3,GPRC6A,TXN,TRPM2,IRF3,BCL2,IFNA8,TRPM7,TAB1,TRPV2,CTSB,NLRP6,GBP3,MCU,MAPK1,VDAC1,PANX1,TRIP6,TNF,ITPR2,IFNA7,CXCL1,CASR,STAT2,STAT1,CHUK,RHOA,MAPK9,NFKB1,ITPR1,IFNA21,NLRP7,RIPK3,IL1B,PYDC2,CASP1,CASP12,NOX3,NOD1,STING1,JAK1,IRF9,TXNIP,MFN1,TBK1,IFNA1,OAS2,PLCB3,ATG5,AIM2,ANTXR2,CARD18,PYDC1,MAPK14,GBP5,TICAM1,MAPK12,CAMP,MYD88,IFI16,IFNA4,P2RX7,RIPK2,BIRC3,IRF7,HSP90AA1,MEFV,PYCARD,PLCB2,DHX33,MAVS,HSP90AB1,TNFAIP3,NLRP12,IL6,IFNAR2,JUN,NAIP,CARD17P,NLRC4,RIPK1,ANTXR1,TLR4,GABARAPL2,DNM1L,PSTPIP1,CASP4,OAS3,IFNA2,IFNA14,CYBA,TAB2,ITPR3,RBCK1,MAPK11,IFNAR1,NAMPT,TRAF6,NOD2,CCL2,VDAC2,ERBIN,VDAC3,MFN2,GBP7,TRAF3,PRKCD,CXCL8,NLRP1,MAP3K7,BCL2L1,TRAF5,GABARAPL1,PLCB4,RNASEL,BIRC2,TANK,IL18,CARD6,IFNA5,IFNA6,MAPK8,GABARAP,TYK2,MAPK10,TXN2,FADD,MAPK13,GBP1,IKBKE,CASP5,SUGT1,ATG16L1,NLRP3,ATG12,IKBKB,GBP4,NEK7,PLCB1,IFNA16,CXCL2,CARD8,IFNB1,RELA,TP53BP1,NLRX1,GSDMD
ko05414	Dilated cardiomyopathy	0.0769438541875724	-2.56467928949473	89	83	0.0131746031746032	6300	7161	8516,3679,9254,3694,779,775,7170,7043,108,7042,59285,7124,6546,3676,3688,3680,196883,3685,3479,60,784,109,5566,6443,3655,7168,6442,115,7139,3695,3690,7273,59284,3673,5567,3672,113,1605,5350,3908,488,783,10368,2778,785,114,4634,93589,3674,6444,27092,4000,7169,3691,4624,6262,7040,4633,70,153,3696,71,112,4607,786,5568,107,1674,7134,55799,4625,6445,10369,3675,7171,3693,776,781,111,59283,22801,8515,27091	ITGA8,ITGA7,CACNA2D2,ITGB6,CACNA1S,CACNA1C,TPM3,TGFB3,ADCY2,TGFB2,CACNG6,TNF,SLC8A1,ITGA4,ITGB1,ITGA9,ADCY4,ITGAV,IGF1,ACTB,CACNB3,ADCY3,PRKACA,SGCB,ITGA6,TPM1,SGCA,ADCY9,TNNT2,ITGB7,ITGB3,TTN,CACNG7,ITGA2,PRKACB,ITGA1,ADCY7,DAG1,PLN,LAMA2,ATP2A2,CACNB2,CACNG3,GNAS,CACNB4,ADCY8,MYL3,CACNA2D4,ITGA2B,SGCD,CACNG4,LMNA,TPM2,ITGB4,MYH6,RYR2,TGFB1,MYL2,ACTC1,ADRB1,ITGB8,ACTG1,ADCY6,MYBPC3,CACNG1,PRKACG,ADCY1,DES,TNNC1,CACNA2D3,MYH7,SGCG,CACNG2,ITGA3,TPM4,ITGB5,CACNA1D,CACNA2D1,ADCY5,CACNG8,ITGA11,ITGA10,CACNG5
hsa05414	Dilated cardiomyopathy	0.0769438541875724	-2.56467928949473	89	83	0.0131746031746032	6300	7161	5566,784,109,115,7139,6443,3655,6442,7168,59284,3673,3672,113,5567,3695,3690,7273,5350,1605,10368,488,2778,783,3908,785,4634,114,9254,8516,3679,3694,779,775,7170,59285,7124,7043,108,7042,3676,6546,3688,3680,3685,196883,60,3479,4625,55799,1674,107,7134,6445,7171,3693,10369,3675,776,781,111,59283,22801,8515,27091,93589,3674,4000,27092,6444,6262,4624,3691,7169,7040,4633,70,3696,153,112,71,4607,786,5568	PRKACA,CACNB3,ADCY3,ADCY9,TNNT2,SGCB,ITGA6,SGCA,TPM1,CACNG7,ITGA2,ITGA1,ADCY7,PRKACB,ITGB7,ITGB3,TTN,PLN,DAG1,CACNG3,ATP2A2,GNAS,CACNB2,LAMA2,CACNB4,MYL3,ADCY8,CACNA2D2,ITGA8,ITGA7,ITGB6,CACNA1S,CACNA1C,TPM3,CACNG6,TNF,TGFB3,ADCY2,TGFB2,ITGA4,SLC8A1,ITGB1,ITGA9,ITGAV,ADCY4,ACTB,IGF1,MYH7,CACNA2D3,DES,ADCY1,TNNC1,SGCG,TPM4,ITGB5,CACNG2,ITGA3,CACNA1D,CACNA2D1,ADCY5,CACNG8,ITGA11,ITGA10,CACNG5,CACNA2D4,ITGA2B,LMNA,CACNG4,SGCD,RYR2,MYH6,ITGB4,TPM2,TGFB1,MYL2,ACTC1,ITGB8,ADRB1,ADCY6,ACTG1,MYBPC3,CACNG1,PRKACG
M00427	Nuclear pore complex	0.079783065274724	-2.52844401164953	45	43	0.00682539682539683	6300	7161	23279,5903,79023,6612,6613,129401,79902,81929,23636,23225,7341,11097,9631,285190,23165,84220,4928,91181,8021,5905,57122,10762,94026,400966,653489,4927,23511,59343,9818,7329,55746,9688,8086,387082,53371,727851,9972,6396,100101267,7175,55706,348995,9883	NUP160,RANBP2,NUP37,SUMO3,SUMO2,NUP35,NUP85,SEH1L,NUP62,NUP210,SUMO1,NUP42,NUP155,RGPD4,NUP205,RGPD5,NUP98,NUP210L,NUP214,RANGAP1,NUP107,NUP50,POM121L2,RGPD1,RGPD3,NUP88,NUP188,SENP2,NUP58,UBE2I,NUP133,NUP93,AAAS,SUMO4,NUP54,RGPD8,NUP153,SEC13,POM121C,TPR,NDC1,NUP43,POM121
hsa_M00427	Nuclear pore complex	0.079783065274724	-2.52844401164953	45	43	0.00682539682539683	6300	7161	84220,91181,4928,23165,348995,9883,8021,11097,100101267,6396,9972,7341,285190,55706,9631,7175,387082,23636,727851,53371,23225,9688,8086,55746,7329,81929,79902,129401,59343,9818,400966,94026,6613,6612,23511,4927,653489,5903,57122,5905,23279,79023,10762	RGPD5,NUP210L,NUP98,NUP205,NUP43,POM121,NUP214,NUP42,POM121C,SEC13,NUP153,SUMO1,RGPD4,NDC1,NUP155,TPR,SUMO4,NUP62,RGPD8,NUP54,NUP210,NUP93,AAAS,NUP133,UBE2I,SEH1L,NUP85,NUP35,SENP2,NUP58,RGPD1,POM121L2,SUMO2,SUMO3,NUP188,NUP88,RGPD3,RANBP2,NUP107,RANGAP1,NUP160,NUP37,NUP50
ko04722	Neurotrophin signaling pathway	0.0800186702527191	-2.52549529337771	119	110	0.0174603174603175	6300	7161	5170,5663,4893,4908,10000,6195,10603,51806,397,208,5605,5594,11108,5781,53358,10818,815,57498,805,4916,1398,163688,808,810,9261,5290,818,25970,596,4793,5335,4792,4803,4217,5595,5604,51135,6464,673,6300,5336,4914,5906,8767,91860,399694,1432,817,5894,468,581,4915,9252,5293,3845,4909,387,4790,6196,5601,11213,2885,207,2549,814,5580,356,5600,2889,25,7189,396,5295,5908,5598,25759,3725,7157,3667,3265,5291,6654,10019,7161,801,4215,5970,5603,3656,5602,8503,5599,4804,5879,5296,4794,3551,7531,2309,4145,5607,4214,627,5664,6655,6272,2932,816,998,5609	PDPK1,PSEN1,NRAS,NTF3,AKT3,RPS6KA1,SH2B2,CALML5,ARHGDIB,AKT2,MAP2K2,MAPK1,PRDM4,PTPN11,SHC3,FRS2,CAMK2A,KIDINS220,CALM2,NTRK3,CRK,CALML6,CALM3,CALML3,MAPKAPK2,PIK3CA,CAMK2G,SH2B1,BCL2,NFKBIB,PLCG1,NFKBIA,NGF,MAP3K5,MAPK3,MAP2K1,IRAK4,SHC1,BRAF,MAPK12,PLCG2,NTRK1,RAP1A,RIPK2,CALML4,SHC4,MAPK14,CAMK2D,RAF1,ATF4,BAX,NTRK2,RPS6KA5,PIK3CD,KRAS,NTF4,RHOA,NFKB1,RPS6KA2,MAPK9,IRAK3,GRB2,AKT1,GAB1,CAMK4,PRKCD,FASLG,MAPK11,RAPGEF1,ABL1,TRAF6,ARHGDIA,PIK3R1,RAP1B,MAPK7,SHC2,JUN,TP53,IRS1,HRAS,PIK3CB,SOS1,SH2B3,TP73,CALM1,MAP3K3,RELA,MAPK13,IRAK2,MAPK10,PIK3R3,MAPK8,NGFR,RAC1,PIK3R2,NFKBIE,IKBKB,YWHAE,FOXO3,MATK,MAP2K5,MAP3K1,BDNF,PSEN2,SOS2,SORT1,GSK3B,CAMK2B,CDC42,MAP2K7
hsa04722	Neurotrophin signaling pathway	0.0800186702527191	-2.52549529337771	119	110	0.0174603174603175	6300	7161	7531,2309,5879,5296,4794,3551,5599,4804,3656,5603,5602,8503,5970,7161,801,4215,6654,10019,3265,5291,998,5609,2932,816,6272,5664,6655,5607,4214,627,4145,7189,2889,25,5600,356,814,5580,5598,3725,25759,7157,3667,5908,5295,396,5894,91860,399694,817,1432,4914,8767,5906,5336,673,6300,11213,2885,207,2549,387,4790,5601,6196,4909,3845,5293,9252,468,581,4915,4916,805,57498,1398,5781,53358,10818,815,11108,5605,5594,208,6195,51806,10603,397,5663,4893,10000,4908,5170,4217,5604,5595,51135,6464,4803,4793,5335,4792,25970,596,818,810,9261,5290,163688,808	YWHAE,FOXO3,RAC1,PIK3R2,NFKBIE,IKBKB,MAPK8,NGFR,IRAK2,MAPK13,MAPK10,PIK3R3,RELA,TP73,CALM1,MAP3K3,SOS1,SH2B3,HRAS,PIK3CB,CDC42,MAP2K7,GSK3B,CAMK2B,SORT1,PSEN2,SOS2,MAP2K5,MAP3K1,BDNF,MATK,TRAF6,RAPGEF1,ABL1,MAPK11,FASLG,CAMK4,PRKCD,MAPK7,JUN,SHC2,TP53,IRS1,RAP1B,PIK3R1,ARHGDIA,RAF1,CALML4,SHC4,CAMK2D,MAPK14,NTRK1,RIPK2,RAP1A,PLCG2,BRAF,MAPK12,IRAK3,GRB2,AKT1,GAB1,RHOA,NFKB1,MAPK9,RPS6KA2,NTF4,KRAS,PIK3CD,RPS6KA5,ATF4,BAX,NTRK2,NTRK3,CALM2,KIDINS220,CRK,PTPN11,SHC3,FRS2,CAMK2A,PRDM4,MAP2K2,MAPK1,AKT2,RPS6KA1,CALML5,SH2B2,ARHGDIB,PSEN1,NRAS,AKT3,NTF3,PDPK1,MAP3K5,MAP2K1,MAPK3,IRAK4,SHC1,NGF,NFKBIB,PLCG1,NFKBIA,SH2B1,BCL2,CAMK2G,CALML3,MAPKAPK2,PIK3CA,CALML6,CALM3
ko04720	Long-term potentiation	0.081644995332948	-2.50537475559061	67	63	0.01	6300	7161	5894,1387,817,5499,91860,5568,5331,5906,2903,5582,2890,10411,801,2776,3265,23236,673,5502,5533,5532,5578,6196,5332,2906,3708,816,107,2915,3845,5501,468,805,3709,815,3710,5579,5594,5605,5534,2911,2905,814,51806,6195,4893,5500,775,5595,5604,5530,5535,114,2033,5330,5908,818,2891,5566,810,2904,808,163688,5567	RAF1,CREBBP,CAMK2D,PPP1CA,CALML4,PRKACG,PLCB3,RAP1A,GRIN2A,PRKCG,GRIA1,RAPGEF3,CALM1,GNAQ,HRAS,PLCB1,BRAF,PPP1R1A,PPP3CC,PPP3CB,PRKCA,RPS6KA2,PLCB4,GRIN2D,ITPR1,CAMK2B,ADCY1,GRM5,KRAS,PPP1CC,ATF4,CALM2,ITPR2,CAMK2A,ITPR3,PRKCB,MAPK1,MAP2K2,PPP3R1,GRM1,GRIN2C,CAMK4,CALML5,RPS6KA1,NRAS,PPP1CB,CACNA1C,MAPK3,MAP2K1,PPP3CA,PPP3R2,ADCY8,EP300,PLCB2,RAP1B,CAMK2G,GRIA2,PRKACA,CALML3,GRIN2B,CALM3,CALML6,PRKACB
hsa04720	Long-term potentiation	0.081644995332948	-2.50537475559061	67	63	0.01	6300	7161	4893,775,5500,2911,814,2905,6195,51806,3710,5579,815,5594,5605,5534,805,3709,810,5567,808,163688,2904,2891,5566,818,5330,114,2033,5908,5595,5530,5604,5535,23236,673,5502,2776,3265,2890,10411,2903,5906,5582,801,5568,5331,5894,91860,5499,817,1387,5501,468,2915,3845,107,6196,5332,3708,816,2906,5578,5533,5532	NRAS,CACNA1C,PPP1CB,GRM1,CAMK4,GRIN2C,RPS6KA1,CALML5,ITPR3,PRKCB,CAMK2A,MAPK1,MAP2K2,PPP3R1,CALM2,ITPR2,CALML3,PRKACB,CALM3,CALML6,GRIN2B,GRIA2,PRKACA,CAMK2G,PLCB2,ADCY8,EP300,RAP1B,MAPK3,PPP3CA,MAP2K1,PPP3R2,PLCB1,BRAF,PPP1R1A,GNAQ,HRAS,GRIA1,RAPGEF3,GRIN2A,RAP1A,PRKCG,CALM1,PRKACG,PLCB3,RAF1,CALML4,PPP1CA,CAMK2D,CREBBP,PPP1CC,ATF4,GRM5,KRAS,ADCY1,RPS6KA2,PLCB4,ITPR1,CAMK2B,GRIN2D,PRKCA,PPP3CC,PPP3CB
hsa_M00684	JAK-STAT signaling	0.0874079029300248	-2.43716957786819	19	19	0.00301587301587302	6300	7161	122809,3717,8835,6774,3716,6778,6775,30837,6773,1154,6772,9655,9021,7297,8651,6776,3718,9306,6777	SOCS4,JAK2,SOCS2,STAT3,JAK1,STAT6,STAT4,SOCS7,STAT2,CISH,STAT1,SOCS5,SOCS3,TYK2,SOCS1,STAT5A,JAK3,SOCS6,STAT5B
M00684	JAK-STAT signaling	0.0874079029300248	-2.43716957786819	19	19	0.00301587301587302	6300	7161	122809,3717,8835,6774,3716,6778,30837,6775,6773,1154,6772,9655,9021,8651,7297,6776,3718,9306,6777	SOCS4,JAK2,SOCS2,STAT3,JAK1,STAT6,SOCS7,STAT4,STAT2,CISH,STAT1,SOCS5,SOCS3,SOCS1,TYK2,STAT5A,JAK3,SOCS6,STAT5B
ko00640	Propanoate metabolism	0.0886347863253999	-2.42323087624418	32	31	0.00492063492063492	6300	7161	84693,4594,34,3939,38,1738,26275,5096,8801,160287,92483,32,23417,593,3030,84532,5095,18,1962,594,55902,3945,39,3948,4329,79611,55862,31,8803,1629,8802	MCEE,MMUT,ACADM,LDHA,ACAT1,DLD,HIBCH,PCCB,SUCLG2,LDHAL6A,LDHAL6B,ACACB,MLYCD,BCKDHA,HADHA,ACSS1,PCCA,ABAT,EHHADH,BCKDHB,ACSS2,LDHB,ACAT2,LDHC,ALDH6A1,ACSS3,ECHDC1,ACACA,SUCLA2,DBT,SUCLG1
hsa00640	Propanoate metabolism	0.0886347863253999	-2.42323087624418	32	31	0.00492063492063492	6300	7161	34,3939,1738,38,84693,4594,8801,160287,32,92483,26275,5096,5095,18,1962,84532,3030,23417,593,31,4329,55862,79611,1629,8803,8802,594,3945,55902,39,3948	ACADM,LDHA,DLD,ACAT1,MCEE,MMUT,SUCLG2,LDHAL6A,ACACB,LDHAL6B,HIBCH,PCCB,PCCA,ABAT,EHHADH,ACSS1,HADHA,MLYCD,BCKDHA,ACACA,ALDH6A1,ECHDC1,ACSS3,DBT,SUCLA2,SUCLG1,BCKDHB,LDHB,ACSS2,ACAT2,LDHC
ko04140	Autophagy - animal	0.0894979892848221	-2.41353912004507	127	117	0.0185714285714286	6300	7161	83734,5289,207,3708,64798,9776,5601,3845,58476,9821,55626,1514,5293,29982,83452,7249,7879,5894,9474,8660,9451,5568,64223,1965,2475,54541,10645,51100,1509,64422,5595,5604,7248,1508,79065,596,5567,3091,3630,3916,5290,60673,5605,5594,5562,5563,440275,22808,9706,3480,208,5170,4893,84335,10000,8678,89849,9711,22800,23710,64419,598,6199,55578,53349,5515,9140,5296,55054,5602,57521,8503,22863,6009,5599,11337,23130,3265,5291,84938,664,55014,64121,8673,3667,23604,5728,5566,285973,10533,2081,11345,3146,10670,6794,30849,5295,5516,6237,8408,1613,7189,58528,1612,26100,81671,8897,8837,9110,55062,6198,7405,6885,84971,5588,5580,55102	ATG10,PIK3C3,AKT1,ITPR1,DEPTOR,ATG13,MAPK9,KRAS,TP53INP2,RB1CC1,AMBRA1,CTSL,PIK3CD,NRBF2,RAB33B,TSC2,RAB7A,RAF1,ATG5,IRS2,EIF2AK3,PRKACG,MLST8,EIF2S1,MTOR,DDIT4,CAMKK2,SH3GLB1,CTSD,ATG3,MAPK3,MAP2K1,TSC1,CTSB,ATG9A,BCL2,PRKACB,HIF1A,INS,LAMP1,PIK3CA,ATG101,MAP2K2,MAPK1,PRKAA1,PRKAA2,EIF2AK4,MRAS,ULK2,IGF1R,AKT2,PDPK1,NRAS,AKT1S1,AKT3,BECN1,ATG16L2,RUBCN,RRAS2,GABARAPL1,MTMR14,BCL2L1,RPS6KB2,SUPT20H,ZFYVE1,PPP2CA,ATG12,PIK3R2,ATG16L1,MAPK10,RPTOR,PIK3R3,ATG14,RHEB,MAPK8,GABARAP,ATG2A,HRAS,PIK3CB,ATG4C,BNIP3,STX17,RRAGC,VAMP8,IRS1,DAPK2,PTEN,PRKACA,ATG9B,ATG7,ERN1,GABARAPL2,HMGB1,RRAGA,STK11,PIK3R4,PIK3R1,PPP2CB,RRAS,ULK1,DAPK3,TRAF6,RRAGD,DAPK1,WIPI2,VMP1,MTMR3,CFLAR,MTMR4,WIPI1,RPS6KB1,UVRAG,MAP3K7,ATG4D,PRKCQ,PRKCD,ATG2B
hsa04140	Autophagy - animal	0.0894979892848221	-2.41353912004507	127	117	0.0185714285714286	6300	7161	55578,5515,53349,6199,89849,8678,598,64419,23710,22800,9711,23130,5291,84938,3265,55054,5296,9140,6009,5599,22863,11337,57521,5602,8503,10533,5566,285973,6794,30849,10670,3146,5295,11345,2081,64121,8673,23604,3667,664,55014,5728,55102,5580,5588,7405,6198,84971,6885,1612,58528,7189,8408,1613,5516,6237,8837,9110,8897,55062,81671,26100,55626,58476,3845,9821,5293,1514,5289,207,83734,5601,3708,64798,9776,2475,1965,54541,64223,64422,51100,10645,1509,5894,7249,7879,29982,83452,9451,8660,5568,9474,79065,596,1508,3916,5290,5567,3630,3091,5595,5604,7248,9706,208,3480,22808,4893,84335,10000,5170,60673,5563,5562,440275,5605,5594	SUPT20H,PPP2CA,ZFYVE1,RPS6KB2,ATG16L2,BECN1,BCL2L1,MTMR14,GABARAPL1,RRAS2,RUBCN,ATG2A,PIK3CB,ATG4C,HRAS,ATG16L1,PIK3R2,ATG12,RHEB,MAPK8,ATG14,GABARAP,RPTOR,MAPK10,PIK3R3,ATG7,PRKACA,ATG9B,STK11,PIK3R4,RRAGA,HMGB1,PIK3R1,GABARAPL2,ERN1,RRAGC,VAMP8,DAPK2,IRS1,BNIP3,STX17,PTEN,ATG2B,PRKCD,PRKCQ,UVRAG,RPS6KB1,ATG4D,MAP3K7,DAPK1,RRAGD,TRAF6,ULK1,DAPK3,PPP2CB,RRAS,CFLAR,MTMR4,MTMR3,WIPI1,VMP1,WIPI2,AMBRA1,TP53INP2,KRAS,RB1CC1,PIK3CD,CTSL,PIK3C3,AKT1,ATG10,MAPK9,ITPR1,DEPTOR,ATG13,MTOR,EIF2S1,DDIT4,MLST8,ATG3,SH3GLB1,CAMKK2,CTSD,RAF1,TSC2,RAB7A,NRBF2,RAB33B,EIF2AK3,IRS2,PRKACG,ATG5,ATG9A,BCL2,CTSB,LAMP1,PIK3CA,PRKACB,INS,HIF1A,MAPK3,MAP2K1,TSC1,ULK2,AKT2,IGF1R,MRAS,NRAS,AKT1S1,AKT3,PDPK1,ATG101,PRKAA2,PRKAA1,EIF2AK4,MAP2K2,MAPK1
ko04659	Th17 cell differentiation	0.0899535212294912	-2.40846217283161	107	99	0.0157142857142857	6300	7161	112744,3716,3117,2625,3553,3119,4773,4772,5601,4790,3570,2475,3320,6778,917,6300,3932,920,7040,7048,3565,3459,1432,3112,3113,3559,861,149233,3566,3091,5595,6777,5535,50616,3558,4792,5335,4793,59067,3572,3458,915,6772,1147,919,30009,6095,6256,3118,5594,5534,916,6774,6258,3717,3122,3123,5533,5532,5914,6097,53342,3108,3111,4088,5970,3127,2353,3556,3560,4794,3551,5599,3460,7297,5602,5603,9466,4089,7046,50615,5530,3725,4087,7535,6776,27040,3326,4775,3569,5588,3662,196,3605,3594,3109,3718,3554,5600	IL17F,JAK1,HLA-DQA1,GATA3,IL1B,HLA-DQB1,NFATC2,NFATC1,MAPK9,NFKB1,IL6R,MTOR,HSP90AA1,STAT6,CD3G,MAPK12,LCK,CD4,TGFB1,TGFBR2,IL4,IFNGR1,MAPK14,HLA-DOB,HLA-DPA1,IL2RA,RUNX1,IL23R,IL4R,HIF1A,MAPK3,STAT5B,PPP3R2,IL22,IL2,NFKBIA,PLCG1,NFKBIB,IL21,IL6ST,IFNG,CD3D,STAT1,CHUK,CD247,TBX21,RORA,RXRA,HLA-DQA2,MAPK1,PPP3R1,CD3E,STAT3,RXRG,JAK2,HLA-DRA,HLA-DRB1,PPP3CC,PPP3CB,RARA,RORC,IL17D,HLA-DMA,HLA-DOA,SMAD3,RELA,HLA-DRB5,FOS,IL1RAP,IL2RB,NFKBIE,IKBKB,MAPK8,IFNGR2,TYK2,MAPK10,MAPK13,IL27RA,SMAD4,TGFBR1,IL21R,PPP3CA,JUN,SMAD2,ZAP70,STAT5A,LAT,HSP90AB1,NFATC3,IL6,PRKCQ,IRF4,AHR,IL17A,IL12RB1,HLA-DMB,JAK3,IL1R1,MAPK11
hsa04931	Insulin resistance	0.0899535212294912	-2.40846217283161	107	99	0.0157142857142857	6300	7161	6720,51422,5506,9586,207,10999,6196,5601,4790,5581,5524,5293,200186,5501,5834,10488,8660,2475,10724,4792,57818,90993,4846,57761,3630,22877,5290,7124,5571,64764,5563,5562,5781,6195,11000,5836,208,5170,6514,10000,5564,5105,133522,2932,1374,5507,3643,53632,5509,6513,6199,6774,10891,5296,5499,3551,5465,6517,84699,5602,9021,8503,5599,376497,5565,28965,10062,5970,5291,79660,2997,948,5590,32,3667,3569,5728,2998,2308,92579,1385,148327,5295,51085,2673,9945,5579,6198,11001,5580,5588,7376,9882,5770,2538,5500,5792,5837,7132	SREBF1,PRKAG2,PPP1R3A,CREB5,AKT1,SLC27A4,RPS6KA2,MAPK9,NFKB1,PRKCE,PTPA,PIK3CD,CRTC2,PPP1CC,PYGB,CREB3,IRS2,MTOR,OGA,NFKBIA,G6PC2,CREB3L1,NOS3,TRIB3,INS,MLXIP,PIK3CA,TNF,PRKAG1,CREB3L2,PRKAA2,PRKAA1,PTPN11,RPS6KA1,SLC27A3,PYGL,AKT2,PDPK1,SLC2A2,AKT3,PRKAB1,PCK1,PPARGC1B,GSK3B,CPT1A,PPP1R3C,INSR,PRKAG3,PPP1R3D,SLC2A1,RPS6KB2,STAT3,PPARGC1A,PIK3R2,PPP1CA,IKBKB,PPARA,SLC2A4,CREB3L3,MAPK10,SOCS3,PIK3R3,MAPK8,SLC27A1,PRKAB2,SLC27A6,NR1H3,RELA,PIK3CB,PPP1R3B,GYS1,CD36,PRKCZ,ACACB,IRS1,IL6,PTEN,GYS2,FOXO1,G6PC3,CREB1,CREB3L4,PIK3R1,MLXIPL,GFPT1,GFPT2,PRKCB,RPS6KB1,SLC27A2,PRKCD,PRKCQ,NR1H2,TBC1D4,PTPN1,G6PC1,PPP1CB,PTPRF,PYGM,TNFRSF1A
hsa04659	Th17 cell differentiation	0.0899535212294912	-2.40846217283161	107	99	0.0157142857142857	6300	7161	2475,3320,6778,917,6300,3932,920,7048,3565,7040,1432,3459,3113,3112,3559,112744,3716,3117,2625,3553,3119,4772,4773,4790,5601,3570,6772,915,1147,919,30009,6095,6256,3118,5534,5594,861,3566,149233,3091,5535,6777,5595,3558,50616,4793,5335,4792,3572,59067,3458,4088,5970,3127,2353,3556,4794,3560,3551,3460,5599,7297,5603,5602,916,6774,6258,3717,3123,3122,5532,5533,5914,6097,53342,3111,3108,5588,3662,196,3605,3594,3109,3718,3554,5600,9466,7046,4089,50615,3725,5530,4087,7535,6776,27040,4775,3326,3569	MTOR,HSP90AA1,STAT6,CD3G,MAPK12,LCK,CD4,TGFBR2,IL4,TGFB1,MAPK14,IFNGR1,HLA-DPA1,HLA-DOB,IL2RA,IL17F,JAK1,HLA-DQA1,GATA3,IL1B,HLA-DQB1,NFATC1,NFATC2,NFKB1,MAPK9,IL6R,STAT1,CD3D,CHUK,CD247,TBX21,RORA,RXRA,HLA-DQA2,PPP3R1,MAPK1,RUNX1,IL4R,IL23R,HIF1A,PPP3R2,STAT5B,MAPK3,IL2,IL22,NFKBIB,PLCG1,NFKBIA,IL6ST,IL21,IFNG,SMAD3,RELA,HLA-DRB5,FOS,IL1RAP,NFKBIE,IL2RB,IKBKB,IFNGR2,MAPK8,TYK2,MAPK13,MAPK10,CD3E,STAT3,RXRG,JAK2,HLA-DRB1,HLA-DRA,PPP3CB,PPP3CC,RARA,RORC,IL17D,HLA-DOA,HLA-DMA,PRKCQ,IRF4,AHR,IL17A,IL12RB1,HLA-DMB,JAK3,IL1R1,MAPK11,IL27RA,TGFBR1,SMAD4,IL21R,JUN,PPP3CA,SMAD2,ZAP70,STAT5A,LAT,NFATC3,HSP90AB1,IL6
ko05100	Bacterial invasion of epithelial cells	0.0918149507319947	-2.38798013261197	76	71	0.0112698412698413	6300	7161	1211,10093,124404,867,6464,25759,3059,8976,5747,5290,5295,857,1793,3688,391,53358,1212,1213,81873,55752,60,1495,55964,3611,23607,1398,10552,10459,2335,10801,1759,1731,26084,29119,1499,387,9564,998,2549,6714,23624,63916,8936,1496,5293,859,10094,5829,8218,71,10095,4233,8503,858,2017,5879,5296,399694,1785,23176,10092,7414,5291,79658,10109,26052,10163,868,9844,79767,999	CLTA,ARPC4,SEPTIN12,CBL,SHC1,SHC2,HCLS1,WASL,PTK2,PIK3CA,PIK3R1,CAV1,DOCK1,ITGB1,RHOG,SHC3,CLTB,CLTC,ARPC5L,SEPTIN11,ACTB,CTNNA1,SEPTIN3,ILK,CD2AP,CRK,ARPC1A,MAD2L2,FN1,SEPTIN9,DNM1,SEPTIN1,ARHGEF26,CTNNA3,CTNNB1,RHOA,BCAR1,CDC42,GAB1,SRC,CBLC,ELMO2,WASF1,CTNNA2,PIK3CD,CAV3,ARPC3,PXN,CLTCL1,ACTG1,ARPC1B,MET,PIK3R3,CAV2,CTTN,RAC1,PIK3R2,SHC4,DNM2,SEPTIN8,ARPC5,VCL,PIK3CB,ARHGAP10,ARPC2,DNM3,WASF2,CBLB,ELMO1,ELMO3,CDH1
ko05133	Pertussis	0.0918149507319947	-2.38798013261197	76	71	0.0112698412698413	6300	7161	836,715,713,3576,51806,3394,5594,3688,5600,6374,114609,7189,805,729238,7124,722,714,7099,810,163688,808,3661,727,3569,710,718,51135,3684,3725,5595,2770,2353,3659,148022,6300,4615,5970,717,23643,29108,801,840,5599,720,5602,5603,1432,114548,2771,91860,725,353376,716,10392,1073,1072,929,653509,5601,4790,387,3592,3593,2773,712,3552,6372,3586,3553,3689,834	CASP3,C1R,C1QB,CXCL8,CALML5,IRF8,MAPK1,ITGB1,MAPK11,CXCL5,TIRAP,TRAF6,CALM2,SFTPA2,TNF,C4BPA,C1QC,TLR4,CALML3,CALML6,CALM3,IRF3,C5,IL6,SERPING1,C3,IRAK4,ITGAM,JUN,MAPK3,GNAI1,FOS,IRF1,TICAM1,MAPK12,MYD88,RELA,C2,LY96,PYCARD,CALM1,CASP7,MAPK8,C4A,MAPK10,MAPK13,MAPK14,NLRP3,GNAI2,CALML4,C4BPB,TICAM2,C1S,NOD1,CFL2,CFL1,CD14,SFTPA1,MAPK9,NFKB1,RHOA,IL12A,IL12B,GNAI3,C1QA,IL1A,CXCL6,IL10,IL1B,ITGB2,CASP1
hsa05100	Bacterial invasion of epithelial cells	0.0918149507319947	-2.38798013261197	76	71	0.0112698412698413	6300	7161	1211,10093,867,124404,6464,25759,8976,3059,5747,5295,5290,857,1793,3688,391,81873,55752,1213,1212,53358,60,1495,55964,1398,23607,3611,10552,10459,2335,10801,1731,1759,26084,1499,29119,9564,387,998,2549,6714,23624,8936,63916,1496,859,5293,5829,10094,8218,8503,4233,10095,71,858,5296,1785,399694,2017,5879,23176,10092,5291,7414,79658,10109,26052,10163,9844,868,999,79767	CLTA,ARPC4,CBL,SEPTIN12,SHC1,SHC2,WASL,HCLS1,PTK2,PIK3R1,PIK3CA,CAV1,DOCK1,ITGB1,RHOG,ARPC5L,SEPTIN11,CLTC,CLTB,SHC3,ACTB,CTNNA1,SEPTIN3,CRK,CD2AP,ILK,ARPC1A,MAD2L2,FN1,SEPTIN9,SEPTIN1,DNM1,ARHGEF26,CTNNB1,CTNNA3,BCAR1,RHOA,CDC42,GAB1,SRC,CBLC,WASF1,ELMO2,CTNNA2,CAV3,PIK3CD,PXN,ARPC3,CLTCL1,PIK3R3,MET,ARPC1B,ACTG1,CAV2,PIK3R2,DNM2,SHC4,CTTN,RAC1,SEPTIN8,ARPC5,PIK3CB,VCL,ARHGAP10,ARPC2,DNM3,WASF2,ELMO1,CBLB,CDH1,ELMO3
hsa05133	Pertussis	0.0918149507319947	-2.38798013261197	76	71	0.0112698412698413	6300	7161	653509,10392,1073,1072,929,725,716,353376,3689,834,2773,712,3552,3553,6372,3586,3592,3593,5601,4790,387,29108,801,717,5970,23643,6300,4615,2353,3659,148022,1432,114548,2771,91860,5602,5603,840,5599,720,727,3661,808,163688,7099,810,718,51135,5595,3684,3725,2770,3569,710,51806,713,3576,715,836,729238,7124,722,714,114609,805,7189,5594,5600,3688,6374,3394	SFTPA1,NOD1,CFL2,CFL1,CD14,C4BPB,C1S,TICAM2,ITGB2,CASP1,GNAI3,C1QA,IL1A,IL1B,CXCL6,IL10,IL12A,IL12B,MAPK9,NFKB1,RHOA,PYCARD,CALM1,C2,RELA,LY96,MAPK12,MYD88,FOS,IRF1,TICAM1,MAPK14,NLRP3,GNAI2,CALML4,MAPK10,MAPK13,CASP7,MAPK8,C4A,C5,IRF3,CALM3,CALML6,TLR4,CALML3,C3,IRAK4,MAPK3,ITGAM,JUN,GNAI1,IL6,SERPING1,CALML5,C1QB,CXCL8,C1R,CASP3,SFTPA2,TNF,C4BPA,C1QC,TIRAP,CALM2,TRAF6,MAPK1,MAPK11,ITGB1,CXCL5,IRF8
ko04710	Circadian rhythm	0.0982290911685441	-2.32045286341447	31	30	0.00476190476190476	6300	7161	9978,6095,8454,5187,8945,8863,6500,23291,79365,1407,1453,5565,5563,5562,5571,406,8553,1408,8864,4862,1385,9572,9575,53632,6097,1454,5564,51422,26224,6096	RBX1,RORA,CUL1,PER1,BTRC,PER3,SKP1,FBXW11,BHLHE41,CRY1,CSNK1D,PRKAB2,PRKAA2,PRKAA1,PRKAG1,BMAL1,BHLHE40,CRY2,PER2,NPAS2,CREB1,NR1D1,CLOCK,PRKAG3,RORC,CSNK1E,PRKAB1,PRKAG2,FBXL3,RORB
hsa04710	Circadian rhythm	0.0982290911685441	-2.32045286341447	31	30	0.00476190476190476	6300	7161	51422,6096,26224,5564,1454,6097,53632,9575,9572,1385,4862,1408,8864,8553,406,5571,5563,5562,5565,1453,1407,79365,23291,6500,8945,8863,5187,8454,9978,6095	PRKAG2,RORB,FBXL3,PRKAB1,CSNK1E,RORC,PRKAG3,CLOCK,NR1D1,CREB1,NPAS2,CRY2,PER2,BHLHE40,BMAL1,PRKAG1,PRKAA2,PRKAA1,PRKAB2,CSNK1D,CRY1,BHLHE41,FBXW11,SKP1,BTRC,PER3,PER1,CUL1,RBX1,RORA
hsa04137	Mitophagy - animal	0.102232951291836	-2.2805012334933	64	60	0.00952380952380952	6300	7161	9101,54543,8408,6237,283106,4893,9927,9958,65018,22808,23786,84749,3725,7157,664,8887,665,11345,3091,8878,79065,285973,29110,55669,9451,5599,11337,5602,9474,7942,4286,7879,2309,1869,7314,64786,3265,10370,5970,4077,23710,192111,598,5601,22800,1459,8678,6714,10133,6667,468,1457,10241,51024,55626,55288,89941,5071,79735,3845	USP8,TOMM7,ULK1,RRAS,CSNK2A3,NRAS,MFN2,USP15,PINK1,MRAS,BCL2L13,USP30,JUN,TP53,BNIP3,TAX1BP1,BNIP3L,GABARAPL2,HIF1A,SQSTM1,ATG9A,ATG9B,TBK1,MFN1,EIF2AK3,MAPK8,GABARAP,MAPK10,ATG5,TFEB,MITF,RAB7A,FOXO3,E2F1,UBB,TBC1D15,HRAS,CITED2,RELA,NBR1,GABARAPL1,PGAM5,BCL2L1,MAPK9,RRAS2,CSNK2A2,BECN1,SRC,OPTN,SP1,ATF4,CSNK2A1,CALCOCO2,FIS1,AMBRA1,RHOT1,RHOT2,PRKN,TBC1D17,KRAS
hsa05212	Pancreatic cancer	0.102232951291836	-2.2805012334933	64	60	0.00952380952380952	6300	7161	2064,5900,4087,7157,5604,5595,5290,5295,4089,7046,7039,5881,1950,5594,7043,842,7042,1870,5899,10928,7422,10000,1147,6772,208,5898,4790,1021,5601,598,1029,998,207,5925,1871,6774,5293,3716,3845,8503,1019,5602,5599,1956,3551,1869,5879,7040,7048,5296,5894,5337,5291,673,5880,5888,595,4088,5970,675	ERBB2,RALGDS,SMAD2,TP53,MAP2K1,MAPK3,PIK3CA,PIK3R1,SMAD4,TGFBR1,TGFA,RAC3,EGF,MAPK1,TGFB3,CASP9,TGFB2,E2F2,RALB,RALBP1,VEGFA,AKT3,CHUK,STAT1,AKT2,RALA,NFKB1,CDK6,MAPK9,BCL2L1,CDKN2A,CDC42,AKT1,RB1,E2F3,STAT3,PIK3CD,JAK1,KRAS,PIK3R3,CDK4,MAPK10,MAPK8,EGFR,IKBKB,E2F1,RAC1,TGFB1,TGFBR2,PIK3R2,RAF1,PLD1,PIK3CB,BRAF,RAC2,RAD51,CCND1,SMAD3,RELA,BRCA2
ko04137	Mitophagy - animal	0.102232951291836	-2.2805012334933	64	60	0.00952380952380952	6300	7161	65018,9958,22808,4893,9927,8408,283106,6237,9101,54543,79065,285973,8887,665,11345,3091,8878,3725,7157,664,23786,84749,5970,10370,4077,7314,64786,3265,7942,7879,4286,2309,1869,29110,55669,5599,9451,11337,5602,9474,89941,55288,55626,5071,79735,3845,468,1457,51024,10241,1459,8678,6714,10133,6667,23710,192111,598,5601,22800	PINK1,USP15,MRAS,NRAS,MFN2,ULK1,CSNK2A3,RRAS,USP8,TOMM7,ATG9A,ATG9B,TAX1BP1,BNIP3L,GABARAPL2,HIF1A,SQSTM1,JUN,TP53,BNIP3,BCL2L13,USP30,RELA,CITED2,NBR1,UBB,TBC1D15,HRAS,TFEB,RAB7A,MITF,FOXO3,E2F1,TBK1,MFN1,MAPK8,EIF2AK3,GABARAP,MAPK10,ATG5,RHOT2,RHOT1,AMBRA1,PRKN,TBC1D17,KRAS,ATF4,CSNK2A1,FIS1,CALCOCO2,CSNK2A2,BECN1,SRC,OPTN,SP1,GABARAPL1,PGAM5,BCL2L1,MAPK9,RRAS2
ko05212	Pancreatic cancer	0.102232951291836	-2.2805012334933	64	60	0.00952380952380952	6300	7161	3845,3716,6774,5293,998,1029,5925,1871,207,5898,598,4790,5601,1021,595,675,5970,4088,673,5880,5888,5337,5291,7040,7048,5879,5296,3551,1869,5894,5602,8503,1019,1956,5599,1950,5881,5290,4089,5295,7046,7039,4087,5595,5604,7157,2064,5900,6772,1147,208,10928,10000,7422,1870,5899,842,7043,7042,5594	KRAS,JAK1,STAT3,PIK3CD,CDC42,CDKN2A,RB1,E2F3,AKT1,RALA,BCL2L1,NFKB1,MAPK9,CDK6,CCND1,BRCA2,RELA,SMAD3,BRAF,RAC2,RAD51,PLD1,PIK3CB,TGFB1,TGFBR2,RAC1,PIK3R2,IKBKB,E2F1,RAF1,MAPK10,PIK3R3,CDK4,EGFR,MAPK8,EGF,RAC3,PIK3CA,SMAD4,PIK3R1,TGFBR1,TGFA,SMAD2,MAPK3,MAP2K1,TP53,ERBB2,RALGDS,STAT1,CHUK,AKT2,RALBP1,AKT3,VEGFA,E2F2,RALB,CASP9,TGFB3,TGFB2,MAPK1
ko04145	Phagosome	0.111011151002947	-2.19812462322951	152	139	0.0220634920634921	6300	7161	1311,3690,3673,9146,3916,7060,4688,1778,64581,9103,51143,4973,6890,9114,50617,10382,6441,8685,8417,3106,51807,9554,3688,245972,4074,3118,23673,729238,1783,5868,7846,3134,929,1514,3117,3693,525,1520,50508,55176,2214,523,529,3105,5869,347733,3689,83547,5289,3119,4689,2215,10332,4353,3135,2209,84790,81027,30835,653361,3113,3112,347688,1780,7879,200576,528,53407,10333,7099,821,7059,51382,5878,7057,4153,7037,7097,718,10381,22925,3684,9550,1781,2212,2213,715,526,3107,155066,78989,10952,2204,29927,3133,4842,3685,90423,7280,7277,60,1535,3109,127124,79861,79659,8411,7278,112714,245973,653509,4360,11151,10376,10312,535,3108,3111,949,203068,533,9902,3123,3122,7058,811,948,23480,9341,3127,81035,23545,71,4481,84617,51606,5879,8992,6891	COMP,ITGB3,ITGA2,HGS,LAMP1,THBS4,NCF2,DYNC1H1,CLEC7A,FCGR2C,DYNC1LI1,OLR1,TAP1,ATP6V0D1,ATP6V0A4,TUBB4A,SFTPD,MARCO,STX7,HLA-B,TUBA8,SEC22B,ITGB1,ATP6V0D2,M6PR,HLA-DQA2,STX12,SFTPA2,DYNC1LI2,RAB5A,TUBA1A,HLA-F,CD14,CTSL,HLA-DQA1,ITGB5,ATP6V1B1,CTSS,NOX3,SEC61A2,FCGR3A,ATP6V1A,ATP6V1E1,HLA-A,RAB5B,TUBB2B,ITGB2,RILP,PIK3C3,HLA-DQB1,NCF4,FCGR3B,CLEC4M,MPO,HLA-G,FCGR1A,TUBA1C,TUBB1,CD209,NCF1,HLA-DPA1,HLA-DOB,TUBB8,DYNC1I1,RAB7A,PIKFYVE,ATP6V1C1,STX18,TLR6,TLR4,CANX,THBS3,ATP6V1D,RAB5C,THBS1,MBL2,TFRC,TLR2,C3,TUBB3,PLA2R1,ITGAM,ATP6V1G1,DYNC1I2,FCGR2A,FCGR2B,C1R,ATP6V1B2,HLA-C,ATP6V0E2,COLEC11,SEC61B,FCAR,SEC61A1,HLA-E,NOS1,ITGAV,ATP6V1E2,TUBB2A,TUBA4A,ACTB,CYBA,HLA-DMB,ATP6V1G3,TUBAL3,DYNC2H1,EEA1,TUBA3C,TUBA3E,ATP6V1C2,SFTPA1,MRC1,CORO1A,TUBA1B,TCIRG1,ATP6V0A1,HLA-DMA,HLA-DOA,SCARB1,TUBB,ATP6V0B,MRC2,HLA-DRB1,HLA-DRA,THBS2,CALR,CD36,SEC61G,VAMP3,HLA-DRB5,COLEC12,ATP6V0A2,ACTG1,MSR1,TUBB6,ATP6V1H,RAC1,ATP6V0E1,TAP2
hsa04145	Phagosome	0.111011151002947	-2.19812462322951	152	139	0.0220634920634921	6300	7161	50617,9114,6890,4973,9103,51143,1778,64581,4688,3673,1311,3690,3916,7060,9146,1783,729238,5868,7846,245972,4074,9554,3688,23673,3118,6441,10382,3106,51807,8417,8685,3689,83547,5289,3119,5869,3105,347733,55176,523,529,2214,929,1514,3117,3693,525,3134,50508,1520,1780,347688,528,53407,7879,200576,30835,81027,84790,3113,3112,653361,10332,3135,4353,2209,2215,4689,7037,7097,4153,22925,9550,1781,3684,718,10381,5878,7057,51382,7059,10333,821,7099,79861,3109,127124,8411,79659,90423,7280,4842,3685,60,1535,7277,155066,78989,10952,2204,3133,29927,2212,2213,715,3107,526,3123,3122,9902,533,3111,3108,535,203068,949,653509,4360,112714,245973,11151,10312,10376,7278,5879,8992,6891,51606,71,4481,84617,3127,81035,9341,23545,811,7058,948,23480	ATP6V0A4,ATP6V0D1,TAP1,OLR1,FCGR2C,DYNC1LI1,DYNC1H1,CLEC7A,NCF2,ITGA2,COMP,ITGB3,LAMP1,THBS4,HGS,DYNC1LI2,SFTPA2,RAB5A,TUBA1A,ATP6V0D2,M6PR,SEC22B,ITGB1,STX12,HLA-DQA2,SFTPD,TUBB4A,HLA-B,TUBA8,STX7,MARCO,ITGB2,RILP,PIK3C3,HLA-DQB1,RAB5B,HLA-A,TUBB2B,SEC61A2,ATP6V1A,ATP6V1E1,FCGR3A,CD14,CTSL,HLA-DQA1,ITGB5,ATP6V1B1,HLA-F,NOX3,CTSS,DYNC1I1,TUBB8,ATP6V1C1,STX18,RAB7A,PIKFYVE,CD209,TUBB1,TUBA1C,HLA-DPA1,HLA-DOB,NCF1,CLEC4M,HLA-G,MPO,FCGR1A,FCGR3B,NCF4,TFRC,TLR2,MBL2,PLA2R1,ATP6V1G1,DYNC1I2,ITGAM,C3,TUBB3,RAB5C,THBS1,ATP6V1D,THBS3,TLR6,CANX,TLR4,TUBAL3,HLA-DMB,ATP6V1G3,EEA1,DYNC2H1,ATP6V1E2,TUBB2A,NOS1,ITGAV,ACTB,CYBA,TUBA4A,ATP6V0E2,COLEC11,SEC61B,FCAR,HLA-E,SEC61A1,FCGR2A,FCGR2B,C1R,HLA-C,ATP6V1B2,HLA-DRB1,HLA-DRA,MRC2,ATP6V0B,HLA-DOA,HLA-DMA,ATP6V0A1,TUBB,SCARB1,SFTPA1,MRC1,TUBA3E,ATP6V1C2,CORO1A,TCIRG1,TUBA1B,TUBA3C,RAC1,ATP6V0E1,TAP2,ATP6V1H,ACTG1,MSR1,TUBB6,HLA-DRB5,COLEC12,VAMP3,ATP6V0A2,CALR,THBS2,CD36,SEC61G
ko05169	Epstein-Barr virus infection	0.112411240734119	-2.18559133999156	199	181	0.0287301587301587	6300	7161	5713,2960,1432,5704,3683,3113,5431,5901,6688,10623,5336,6300,1459,207,7185,3587,4790,5610,3716,5717,3117,3134,5293,5701,5434,3316,440275,1147,6502,3106,5706,9519,55718,3458,6850,9020,5971,1380,3661,596,7529,5567,6693,5296,3551,7431,3066,8503,960,5599,7297,2959,3127,10971,84265,8021,5441,5291,26993,387332,3306,953,5609,3586,3123,3122,55703,2268,2932,5433,9861,5432,7188,890,10014,7189,5608,5600,952,5707,6885,3133,3107,5702,5714,983,9759,5566,3304,8900,3312,10622,1387,6416,11128,29110,9451,5568,3383,1017,3135,4609,7514,7532,7533,22938,5925,8717,3119,3105,5719,5601,10213,5606,1026,3315,1457,4067,51728,5718,5710,283106,956,3118,3516,208,3588,11047,10000,9612,4793,5335,4792,2033,10454,7979,2208,5290,5440,4734,4794,5439,7531,5603,5602,1386,958,27102,930,5970,548644,23586,5700,5708,9533,661,3310,246721,1027,6774,965,7874,4791,23118,3718,7534,51082,7187,3305,5757,2961,3725,7157,5430,27044,171568,7128,4193,3065,8737,5295	PSMD7,GTF2E1,MAPK14,PSMC4,ITGAL,HLA-DPA1,POLR2B,RAN,SPI1,POLR3C,PLCG2,MAPK12,CSNK2A2,AKT1,TRAF1,IL10RA,NFKB1,EIF2AK2,JAK1,PSMD11,HLA-DQA1,HLA-F,PIK3CD,PSMC2,POLR2E,HSPB2,EIF2AK4,CHUK,SKP2,HLA-B,PSMC6,TBPL1,POLR3E,IFNG,SYK,MAP3K14,RELB,CR2,IRF3,BCL2,YWHAB,PRKACB,SPN,PIK3R2,IKBKB,VIM,HDAC2,PIK3R3,CD44,MAPK8,TYK2,GTF2B,HLA-DRB5,YWHAQ,POLR3GL,NUP214,POLR2L,PIK3CB,AKAP8L,TBPL2,HSPA2,ENTPD1,MAP2K7,IL10,HLA-DRB1,HLA-DRA,POLR3B,FGR,GSK3B,POLR2D,PSMD6,POLR2C,TRAF5,CCNA2,HDAC5,TRAF6,MAP2K6,MAPK11,CD38,PSMD1,MAP3K7,HLA-E,HLA-C,PSMC3,PSMD8,CDK1,HDAC4,PRKACA,HSPA1B,CCNA1,HSPA8,POLR3G,CREBBP,MAP2K4,POLR3A,TBK1,EIF2AK3,PRKACG,ICAM1,CDK2,HLA-G,MYC,XPO1,YWHAG,YWHAH,SNW1,RB1,TRADD,HLA-DQB1,HLA-A,PSMD13,MAPK9,PSMD14,MAP2K3,CDKN1A,HSPB1,CSNK2A1,LYN,POLR3K,PSMD12,PSMD4,CSNK2A3,ENTPD3,HLA-DQA2,RBPJ,AKT2,IL10RB,ADRM1,AKT3,NCOR2,NFKBIB,PLCG1,NFKBIA,EP300,TAB1,SEM1,FCER2,PIK3CA,POLR2K,NEDD4,NFKBIE,POLR2J,YWHAE,MAPK13,MAPK10,ATF2,CD40,EIF2AK1,CD19,RELA,POLR2J3,RIGI,PSMC1,PSMD2,POLR1C,POLR3D,HSPA6,POLR2J2,CDKN1B,STAT3,CD58,USP7,NFKB2,TAB2,JAK3,YWHAZ,POLR1D,TRAF3,HSPA1L,PTMA,GTF2E2,JUN,TP53,POLR2A,SND1,POLR3H,TNFAIP3,MDM2,HDAC1,RIPK1,PIK3R1
hsa05169	Epstein-Barr virus infection	0.112411240734119	-2.18559133999156	199	181	0.0287301587301587	6300	7161	7529,5567,6693,5971,596,3661,1380,3458,9020,6850,55718,9519,5706,6502,1147,3106,440275,5701,3316,5434,3134,3117,5293,3716,5717,5610,4790,3587,7185,207,1459,6300,5336,10623,5704,3683,6688,5431,5901,3113,1432,2960,5713,3312,10622,8900,3304,9759,5566,983,5714,5702,3107,6885,5707,952,3133,5608,5600,7189,10014,890,9861,5432,5433,2268,2932,7188,5609,953,3306,387332,26993,55703,3122,3586,3123,5291,5441,84265,3127,10971,8021,3066,8503,7431,2959,7297,5599,960,3551,5296,7979,5440,5290,2208,10454,2033,4792,4793,5335,9612,3588,10000,11047,208,956,3516,3118,283106,5718,5710,1457,51728,4067,3315,5606,1026,5719,3105,5601,10213,22938,7533,7532,3119,8717,5925,3383,7514,4609,1017,3135,11128,5568,9451,29110,1387,6416,5295,8737,3065,171568,5430,27044,4193,7128,5757,7157,3725,2961,7187,3305,4791,51082,23118,7534,3718,7874,246721,3310,965,6774,1027,9533,661,548644,5700,5708,23586,958,5970,930,27102,1386,5602,5603,5439,4794,4734,7531	YWHAB,PRKACB,SPN,RELB,BCL2,IRF3,CR2,IFNG,MAP3K14,SYK,POLR3E,TBPL1,PSMC6,SKP2,CHUK,HLA-B,EIF2AK4,PSMC2,HSPB2,POLR2E,HLA-F,HLA-DQA1,PIK3CD,JAK1,PSMD11,EIF2AK2,NFKB1,IL10RA,TRAF1,AKT1,CSNK2A2,MAPK12,PLCG2,POLR3C,PSMC4,ITGAL,SPI1,POLR2B,RAN,HLA-DPA1,MAPK14,GTF2E1,PSMD7,HSPA8,POLR3G,CCNA1,HSPA1B,HDAC4,PRKACA,CDK1,PSMD8,PSMC3,HLA-C,MAP3K7,PSMD1,CD38,HLA-E,MAP2K6,MAPK11,TRAF6,HDAC5,CCNA2,PSMD6,POLR2C,POLR2D,FGR,GSK3B,TRAF5,MAP2K7,ENTPD1,HSPA2,TBPL2,AKAP8L,POLR3B,HLA-DRA,IL10,HLA-DRB1,PIK3CB,POLR2L,POLR3GL,HLA-DRB5,YWHAQ,NUP214,HDAC2,PIK3R3,VIM,GTF2B,TYK2,MAPK8,CD44,IKBKB,PIK3R2,SEM1,POLR2K,PIK3CA,FCER2,TAB1,EP300,NFKBIA,NFKBIB,PLCG1,NCOR2,IL10RB,AKT3,ADRM1,AKT2,ENTPD3,RBPJ,HLA-DQA2,CSNK2A3,PSMD12,PSMD4,CSNK2A1,POLR3K,LYN,HSPB1,MAP2K3,CDKN1A,PSMD13,HLA-A,MAPK9,PSMD14,SNW1,YWHAH,YWHAG,HLA-DQB1,TRADD,RB1,ICAM1,XPO1,MYC,CDK2,HLA-G,POLR3A,PRKACG,EIF2AK3,TBK1,CREBBP,MAP2K4,PIK3R1,RIPK1,HDAC1,POLR3H,POLR2A,SND1,MDM2,TNFAIP3,PTMA,TP53,JUN,GTF2E2,TRAF3,HSPA1L,NFKB2,POLR1D,TAB2,YWHAZ,JAK3,USP7,POLR2J2,HSPA6,CD58,STAT3,CDKN1B,POLR1C,POLR3D,POLR2J3,PSMC1,PSMD2,RIGI,CD40,RELA,CD19,EIF2AK1,ATF2,MAPK10,MAPK13,POLR2J,NFKBIE,NEDD4,YWHAE
ko00450	Selenocompound metabolism	0.113007639917954	-2.18029985266185	17	17	0.0026984126984127	6300	7161	7296,56267,1491,4548,118672,22928,51540,11185,10587,9060,92935,51091,9061,883,4141,22929,114112	TXNRD1,KYAT3,CTH,MTR,PSTK,SEPHS2,SCLY,INMT,TXNRD2,PAPSS2,MARS2,SEPSECS,PAPSS1,KYAT1,MARS1,SEPHS1,TXNRD3
hsa00450	Selenocompound metabolism	0.113007639917954	-2.18029985266185	17	17	0.0026984126984127	6300	7161	10587,11185,22928,51540,7296,56267,4548,1491,118672,114112,4141,22929,51091,9061,883,9060,92935	TXNRD2,INMT,SEPHS2,SCLY,TXNRD1,KYAT3,MTR,CTH,PSTK,TXNRD3,MARS1,SEPHS1,SEPSECS,PAPSS1,KYAT1,PAPSS2,MARS2
ko05219	Bladder cancer	0.114081325950159	-2.17084369939843	41	39	0.00619047619047619	6300	7161	1026,1950,3845,9252,6714,23604,7157,5604,1871,5595,5925,1029,4193,7057,1839,2064,4609,3576,999,11186,595,7422,4893,7380,3265,673,5894,1612,1613,4312,1869,4313,4318,1870,2261,1956,5594,1019,5605	CDKN1A,EGF,KRAS,RPS6KA5,SRC,DAPK2,TP53,MAP2K1,E2F3,MAPK3,RB1,CDKN2A,MDM2,THBS1,HBEGF,ERBB2,MYC,CXCL8,CDH1,RASSF1,CCND1,VEGFA,NRAS,UPK3A,HRAS,BRAF,RAF1,DAPK1,DAPK3,MMP1,E2F1,MMP2,MMP9,E2F2,FGFR3,EGFR,MAPK1,CDK4,MAP2K2
hsa05219	Bladder cancer	0.114081325950159	-2.17084369939843	41	39	0.00619047619047619	6300	7161	1019,5594,5605,1956,2261,4313,1869,4312,1870,4318,5894,1613,1612,3265,7380,673,7422,4893,595,999,11186,3576,4609,2064,1839,4193,7057,1029,7157,23604,6714,5925,5595,5604,1871,9252,1950,3845,1026	CDK4,MAPK1,MAP2K2,EGFR,FGFR3,MMP2,E2F1,MMP1,E2F2,MMP9,RAF1,DAPK3,DAPK1,HRAS,UPK3A,BRAF,VEGFA,NRAS,CCND1,CDH1,RASSF1,CXCL8,MYC,ERBB2,HBEGF,MDM2,THBS1,CDKN2A,TP53,DAPK2,SRC,RB1,MAPK3,MAP2K1,E2F3,RPS6KA5,EGF,KRAS,CDKN1A
ko05410	Hypertrophic cardiomyopathy (HCM)	0.114276373253848	-2.16913543773876	83	77	0.0122222222222222	6300	7161	784,7139,6442,7168,6443,3655,3672,3673,59284,3690,7273,3695,1605,488,10368,783,3908,785,3569,4634,9254,3679,8516,779,3694,775,7170,7124,59285,5571,7042,7043,3676,6546,3685,3680,3688,60,5563,5562,3479,4625,55799,7134,1674,6445,3693,7171,3675,10369,781,776,5564,1636,51422,59283,8515,27091,22801,53632,93589,3674,27092,4000,6444,6262,7169,4624,3691,70,7040,4633,3696,71,4607,5565,786	CACNB3,TNNT2,SGCA,TPM1,SGCB,ITGA6,ITGA1,ITGA2,CACNG7,ITGB3,TTN,ITGB7,DAG1,ATP2A2,CACNG3,CACNB2,LAMA2,CACNB4,IL6,MYL3,CACNA2D2,ITGA7,ITGA8,CACNA1S,ITGB6,CACNA1C,TPM3,TNF,CACNG6,PRKAG1,TGFB2,TGFB3,ITGA4,SLC8A1,ITGAV,ITGA9,ITGB1,ACTB,PRKAA2,PRKAA1,IGF1,MYH7,CACNA2D3,TNNC1,DES,SGCG,ITGB5,TPM4,ITGA3,CACNG2,CACNA2D1,CACNA1D,PRKAB1,ACE,PRKAG2,CACNG8,ITGA10,CACNG5,ITGA11,PRKAG3,CACNA2D4,ITGA2B,CACNG4,LMNA,SGCD,RYR2,TPM2,MYH6,ITGB4,ACTC1,TGFB1,MYL2,ITGB8,ACTG1,MYBPC3,PRKAB2,CACNG1
hsa05410	Hypertrophic cardiomyopathy (HCM)	0.114276373253848	-2.16913543773876	83	77	0.0122222222222222	6300	7161	3672,3673,59284,3690,7273,3695,784,7139,7168,6442,6443,3655,785,3569,4634,1605,488,10368,783,3908,775,7170,9254,3679,8516,779,3694,3685,3680,3688,60,5563,5562,3479,59285,7124,5571,7042,7043,3676,6546,3693,7171,3675,10369,781,776,4625,55799,1674,7134,6445,27091,8515,22801,53632,5564,1636,59283,51422,4000,27092,6444,6262,4624,7169,3691,93589,3674,4607,71,786,5565,70,4633,7040,3696	ITGA1,ITGA2,CACNG7,ITGB3,TTN,ITGB7,CACNB3,TNNT2,TPM1,SGCA,SGCB,ITGA6,CACNB4,IL6,MYL3,DAG1,ATP2A2,CACNG3,CACNB2,LAMA2,CACNA1C,TPM3,CACNA2D2,ITGA7,ITGA8,CACNA1S,ITGB6,ITGAV,ITGA9,ITGB1,ACTB,PRKAA2,PRKAA1,IGF1,CACNG6,TNF,PRKAG1,TGFB2,TGFB3,ITGA4,SLC8A1,ITGB5,TPM4,ITGA3,CACNG2,CACNA2D1,CACNA1D,MYH7,CACNA2D3,DES,TNNC1,SGCG,CACNG5,ITGA10,ITGA11,PRKAG3,PRKAB1,ACE,CACNG8,PRKAG2,LMNA,CACNG4,SGCD,RYR2,MYH6,TPM2,ITGB4,CACNA2D4,ITGA2B,MYBPC3,ACTG1,CACNG1,PRKAB2,ACTC1,MYL2,TGFB1,ITGB8
hsa04726	Serotonergic synapse	0.119357256946116	-2.12563412414033	112	103	0.0163492063492063	6300	7161	3351,7220,6571,3360,7166,285242,59345,239,3265,23236,5582,10411,2788,3356,5332,2773,5578,2790,240,3763,776,3762,3710,5579,3363,3362,121278,283748,3781,3354,247,2782,2561,2783,255189,1843,3355,242,5330,2793,2792,1562,2770,2778,2787,3751,3760,351,54331,100137049,5566,5568,10681,5331,3359,5894,2771,2776,673,3357,3352,3708,1559,1565,111,9177,2784,1557,260293,2560,94235,3845,1573,5743,5742,55970,5594,1558,3709,2791,836,4893,775,8605,779,773,6570,123745,3350,6532,3361,2786,5595,5604,200909,1644,3765,5321,5567,51764,170572,246,2562	HTR1B,TRPC1,SLC18A2,HTR4,TPH1,HTR3E,GNB4,ALOX12,HRAS,PLCB1,PRKCG,RAPGEF3,GNG7,HTR2A,PLCB4,GNAI3,PRKCA,GNG10,ALOX5,KCNJ6,CACNA1D,KCNJ5,ITPR3,PRKCB,HTR7,HTR6,TPH2,PLA2G4D,KCNN2,HTR1E,ALOX15B,GNB1,GABRB2,GNB2,PLA2G4F,DUSP1,HTR1F,ALOX12B,PLCB2,GNGT2,GNGT1,CYP2C18,GNAI1,GNAS,GNG5,KCND2,KCNJ3,APP,GNG2,PLA2G4B,PRKACA,PRKACG,GNB5,PLCB3,HTR3A,RAF1,GNAI2,GNAQ,BRAF,HTR2B,HTR1D,ITPR1,CYP2C9,CYP2D6,ADCY5,HTR3B,GNB3,CYP2C19,CYP4X1,GABRB1,GNG8,KRAS,CYP2J2,PTGS2,PTGS1,GNG12,MAPK1,CYP2C8,ITPR2,GNG11,CASP3,NRAS,CACNA1C,PLA2G4C,CACNA1S,CACNA1A,SLC18A1,PLA2G4E,HTR1A,SLC6A4,HTR5A,GNG4,MAPK3,MAP2K1,HTR3D,DDC,KCNJ9,PLA2G4A,PRKACB,GNG13,HTR3C,ALOX15,GABRB3
ko04392	Hippo signaling pathway -multiple species	0.120388109335669	-2.11703451065499	29	28	0.00444444444444444	6300	7161	9113,79981,4771,10413,7004,166824,83937,5058,26524,122786,126374,23286,55233,9770,11186,8463,84962,92597,60485,7005,7003,8994,25937,1454,54798,6788,79633,8642	LATS1,FRMD1,NF2,YAP1,TEAD4,RASSF6,RASSF4,PAK1,LATS2,FRMD6,WTIP,WWC1,MOB1A,RASSF2,RASSF1,TEAD2,AJUBA,MOB1B,SAV1,TEAD3,TEAD1,LIMD1,WWTR1,CSNK1E,DCHS2,STK3,FAT4,DCHS1
ko05216	Thyroid cancer	0.120388109335669	-2.11703451065499	29	28	0.00444444444444444	6300	7161	1499,5604,5595,8031,7157,10342,5979,6258,3845,6934,51176,5605,5594,6256,5468,8030,7170,7175,4893,6932,673,3265,4609,4914,83439,999,7849,595	CTNNB1,MAP2K1,MAPK3,NCOA4,TP53,TFG,RET,RXRG,KRAS,TCF7L2,LEF1,MAP2K2,MAPK1,RXRA,PPARG,CCDC6,TPM3,TPR,NRAS,TCF7,BRAF,HRAS,MYC,NTRK1,TCF7L1,CDH1,PAX8,CCND1
hsa05216	Thyroid cancer	0.120388109335669	-2.11703451065499	29	28	0.00444444444444444	6300	7161	51176,5605,5594,6256,5468,8030,6932,7170,4893,7175,3265,673,83439,4609,4914,999,7849,595,1499,8031,7157,5595,5604,5979,10342,6258,6934,3845	LEF1,MAP2K2,MAPK1,RXRA,PPARG,CCDC6,TCF7,TPM3,NRAS,TPR,HRAS,BRAF,TCF7L1,MYC,NTRK1,CDH1,PAX8,CCND1,CTNNB1,NCOA4,TP53,MAPK3,MAP2K1,RET,TFG,RXRG,TCF7L2,KRAS
hsa04392	Hippo signaling pathway -multiple species	0.120388109335669	-2.11703451065499	29	28	0.00444444444444444	6300	7161	9770,55233,8463,11186,5058,23286,126374,26524,122786,166824,7004,83937,9113,79981,10413,4771,8642,79633,25937,6788,54798,1454,84962,8994,7003,7005,60485,92597	RASSF2,MOB1A,TEAD2,RASSF1,PAK1,WWC1,WTIP,LATS2,FRMD6,RASSF6,TEAD4,RASSF4,LATS1,FRMD1,YAP1,NF2,DCHS1,FAT4,WWTR1,STK3,DCHS2,CSNK1E,AJUBA,LIMD1,TEAD1,TEAD3,SAV1,MOB1B
hsa04922	Glucagon signaling pathway	0.120759859965726	-2.11395133375227	102	94	0.0149206349206349	6300	7161	1386,5140,5565,31,5465,84699,23236,2997,801,816,57223,1374,5332,53632,5564,5224,5105,5532,5533,2641,10891,5162,6513,5315,3710,3948,108,2538,2645,5837,150094,2998,5330,2308,92483,2778,5530,32,148327,23411,5566,92579,1385,126129,5331,10488,5568,5531,91860,817,1387,5257,23235,5834,2776,2642,5161,3708,160287,51422,207,55671,9586,468,2203,200186,3939,5534,5562,5563,3276,5223,815,3945,64764,3709,5571,5211,805,6514,10000,51806,208,5836,57818,2033,5535,808,163688,5567,810,5261,818,90993	ATF2,PDE3B,PRKAB2,ACACA,PPARA,CREB3L3,PLCB1,GYS1,CALM1,CAMK2B,PPP4R3B,CPT1A,PLCB4,PRKAG3,PRKAB1,PGAM2,PCK1,PPP3CB,PPP3CC,GCG,PPARGC1A,PDHB,SLC2A1,PKM,ITPR3,LDHC,ADCY2,G6PC1,GCK,PYGM,SIK1,GYS2,PLCB2,FOXO1,LDHAL6B,GNAS,PPP3CA,ACACB,CREB3L4,SIRT1,PRKACA,G6PC3,CREB1,CPT1C,PLCB3,CREB3,PRKACG,PPP4C,CALML4,CAMK2D,CREBBP,PHKB,SIK2,PYGB,GNAQ,GCGR,PDHA2,ITPR1,LDHAL6A,PRKAG2,AKT1,PPP4R3A,CREB5,ATF4,FBP1,CRTC2,LDHA,PPP3R1,PRKAA1,PRKAA2,PRMT1,PGAM1,CAMK2A,LDHB,CREB3L2,ITPR2,PRKAG1,PFKL,CALM2,SLC2A2,AKT3,CALML5,AKT2,PYGL,G6PC2,EP300,PPP3R2,CALM3,CALML6,PRKACB,CALML3,PHKG2,CAMK2G,CREB3L1
ko04922	Glucagon signaling pathway	0.120759859965726	-2.11395133375227	102	94	0.0149206349206349	6300	7161	5161,2776,2642,1387,817,5531,91860,5834,5257,23235,5331,5568,10488,3939,468,2203,200186,160287,207,55671,9586,51422,3708,51806,208,5836,6514,10000,5571,64764,3709,5211,805,5534,3276,5223,3945,815,5562,5563,818,5261,90993,5567,808,163688,810,5535,57818,2033,801,23236,2997,31,5465,84699,1386,5565,5140,5162,6513,5315,2641,10891,5224,5564,5532,5533,5105,1374,816,57223,53632,5332,150094,2538,2645,5837,108,3948,3710,5566,1385,126129,92579,148327,23411,32,92483,2778,5530,2998,2308,5330	PDHA2,GNAQ,GCGR,CREBBP,CAMK2D,PPP4C,CALML4,PYGB,PHKB,SIK2,PLCB3,PRKACG,CREB3,LDHA,ATF4,FBP1,CRTC2,LDHAL6A,AKT1,PPP4R3A,CREB5,PRKAG2,ITPR1,CALML5,AKT2,PYGL,SLC2A2,AKT3,PRKAG1,CREB3L2,ITPR2,PFKL,CALM2,PPP3R1,PRMT1,PGAM1,LDHB,CAMK2A,PRKAA1,PRKAA2,CAMK2G,PHKG2,CREB3L1,PRKACB,CALM3,CALML6,CALML3,PPP3R2,G6PC2,EP300,CALM1,PLCB1,GYS1,ACACA,PPARA,CREB3L3,ATF2,PRKAB2,PDE3B,PDHB,SLC2A1,PKM,GCG,PPARGC1A,PGAM2,PRKAB1,PPP3CB,PPP3CC,PCK1,CPT1A,CAMK2B,PPP4R3B,PRKAG3,PLCB4,SIK1,G6PC1,GCK,PYGM,ADCY2,LDHC,ITPR3,PRKACA,CREB1,CPT1C,G6PC3,CREB3L4,SIRT1,ACACB,LDHAL6B,GNAS,PPP3CA,GYS2,FOXO1,PLCB2
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.120857990201754	-2.11313905733018	72	67	0.0106349206349206	6300	7161	51176,60,3685,3688,3680,6546,3676,1832,59285,1495,6932,1824,775,83439,779,3694,89,3679,8516,9254,785,3908,10368,3728,488,783,1605,3690,3695,3672,59284,3673,6442,6443,3655,784,786,71,1000,3696,3691,6262,6444,1829,27092,4000,3674,93589,8515,27091,22801,88,29119,1499,59283,1496,781,776,2697,3675,10369,3693,5318,6445,6934,1674,55799	LEF1,ACTB,ITGAV,ITGB1,ITGA9,SLC8A1,ITGA4,DSP,CACNG6,CTNNA1,TCF7,DSC2,CACNA1C,TCF7L1,CACNA1S,ITGB6,ACTN3,ITGA7,ITGA8,CACNA2D2,CACNB4,LAMA2,CACNG3,JUP,ATP2A2,CACNB2,DAG1,ITGB3,ITGB7,ITGA1,CACNG7,ITGA2,SGCA,SGCB,ITGA6,CACNB3,CACNG1,ACTG1,CDH2,ITGB8,ITGB4,RYR2,SGCD,DSG2,CACNG4,LMNA,ITGA2B,CACNA2D4,ITGA10,CACNG5,ITGA11,ACTN2,CTNNA3,CTNNB1,CACNG8,CTNNA2,CACNA2D1,CACNA1D,GJA1,ITGA3,CACNG2,ITGB5,PKP2,SGCG,TCF7L2,DES,CACNA2D3
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.120857990201754	-2.11313905733018	72	67	0.0106349206349206	6300	7161	6262,3691,27092,4000,1829,6444,3674,93589,786,71,3696,1000,776,2697,1496,781,3693,10369,3675,6445,5318,55799,1674,6934,88,22801,27091,8515,29119,1499,59283,1824,6932,775,3694,779,83439,9254,3679,89,8516,60,51176,3680,3688,3685,3676,6546,1495,59285,1832,59284,3673,3672,3695,3690,3655,6443,6442,784,785,783,3728,488,10368,3908,1605	RYR2,ITGB4,CACNG4,LMNA,DSG2,SGCD,ITGA2B,CACNA2D4,CACNG1,ACTG1,ITGB8,CDH2,CACNA1D,GJA1,CTNNA2,CACNA2D1,ITGB5,CACNG2,ITGA3,SGCG,PKP2,CACNA2D3,DES,TCF7L2,ACTN2,ITGA11,CACNG5,ITGA10,CTNNA3,CTNNB1,CACNG8,DSC2,TCF7,CACNA1C,ITGB6,CACNA1S,TCF7L1,CACNA2D2,ITGA7,ACTN3,ITGA8,ACTB,LEF1,ITGA9,ITGB1,ITGAV,ITGA4,SLC8A1,CTNNA1,CACNG6,DSP,CACNG7,ITGA2,ITGA1,ITGB7,ITGB3,ITGA6,SGCB,SGCA,CACNB3,CACNB4,CACNB2,JUP,ATP2A2,CACNG3,LAMA2,DAG1
ko05204	Chemical carcinogenesis	0.121786751035766	-2.10548370601236	82	76	0.0120634920634921	6300	7161	2947,124,9446,64816,7365,1553,2939,2946,79799,56267,1543,2941,221357,9,125,2949,119391,1559,128,4259,574537,7364,10,54658,2952,2953,6799,54578,130,4257,1646,220,1557,10941,5743,6817,54490,1558,100861540,873,7363,4258,1545,54600,1139,1548,218,127,27306,6822,2944,221,131,54576,2938,54577,54579,405,2052,10720,1562,2950,222,1577,2948,373156,54657,2940,54659,7366,883,3290,1576,1544,54575,126	GSTM3,ADH1A,GSTO1,CYP3A43,UGT2B10,CYP2A13,GSTA2,GSTM2,UGT2A3,KYAT3,CYP1A1,GSTA4,GSTA5,NAT1,ADH1B,GSTM5,GSTO2,CYP2C9,ADH5,MGST3,UGT2A2,UGT2B7,NAT2,UGT1A1,GSTT1,GSTT2,SULT1A2,UGT1A6,ADH6,MGST1,AKR1C2,ALDH1A3,CYP2C19,UGT2A1,PTGS2,SULT1A1,UGT2B28,CYP2C8,CYP3A7-CYP3A51P,CBR1,UGT2B4,MGST2,CYP1B1,UGT1A9,CHRNA7,CYP2A6,ALDH3A1,ADH4,HPGDS,SULT2A1,GSTM1,ALDH3B1,ADH7,UGT1A8,GSTA1,UGT1A7,UGT1A5,ARNT,EPHX1,UGT2B11,CYP2C18,GSTP1,ALDH3B2,CYP3A5,GSTM4,GSTK1,UGT1A4,GSTA3,UGT1A3,UGT2B15,KYAT1,HSD11B1,CYP3A4,CYP1A2,UGT1A10,ADH1C
hsa05204	Chemical carcinogenesis	0.121786751035766	-2.10548370601236	82	76	0.0120634920634921	6300	7161	9446,64816,2947,124,79799,56267,7365,1553,2946,2939,221357,9,1543,2941,2949,119391,125,128,4259,574537,10,7364,1559,2952,2953,54658,6799,1646,1557,220,130,54578,4257,5743,6817,54490,10941,4258,1558,873,100861540,7363,127,218,27306,1139,1545,54600,1548,131,6822,221,2944,54577,54579,2938,54576,1562,2950,405,2052,10720,373156,2940,54657,2948,54659,7366,1577,222,1544,126,54575,883,3290,1576	GSTO1,CYP3A43,GSTM3,ADH1A,UGT2A3,KYAT3,UGT2B10,CYP2A13,GSTM2,GSTA2,GSTA5,NAT1,CYP1A1,GSTA4,GSTM5,GSTO2,ADH1B,ADH5,MGST3,UGT2A2,NAT2,UGT2B7,CYP2C9,GSTT1,GSTT2,UGT1A1,SULT1A2,AKR1C2,CYP2C19,ALDH1A3,ADH6,UGT1A6,MGST1,PTGS2,SULT1A1,UGT2B28,UGT2A1,MGST2,CYP2C8,CBR1,CYP3A7-CYP3A51P,UGT2B4,ADH4,ALDH3A1,HPGDS,CHRNA7,CYP1B1,UGT1A9,CYP2A6,ADH7,SULT2A1,ALDH3B1,GSTM1,UGT1A7,UGT1A5,GSTA1,UGT1A8,CYP2C18,GSTP1,ARNT,EPHX1,UGT2B11,GSTK1,GSTA3,UGT1A4,GSTM4,UGT1A3,UGT2B15,CYP3A5,ALDH3B2,CYP1A2,ADH1C,UGT1A10,KYAT1,HSD11B1,CYP3A4
hsa05014	Amyotrophic lateral sclerosis (ALS)	0.122659476910263	-2.09834324334367	51	48	0.00761904761904762	6300	7161	2905,4741,7132,836,6647,7133,9973,10452,7124,842,5868,4747,5600,4842,5608,5534,5630,596,2891,847,54205,1616,57679,2904,4217,5535,5530,7157,6506,2890,4744,2903,317,6300,5879,1432,5603,5606,79139,84134,581,5532,5533,834,100506742,598,2906,2876	GRIN2C,NEFM,TNFRSF1A,CASP3,SOD1,TNFRSF1B,CCS,TOMM40,TNF,CASP9,RAB5A,NEFL,MAPK11,NOS1,MAP2K6,PPP3R1,PRPH,BCL2,GRIA2,CAT,CYCS,DAXX,ALS2,GRIN2B,MAP3K5,PPP3R2,PPP3CA,TP53,SLC1A2,GRIA1,NEFH,GRIN2A,APAF1,MAPK12,RAC1,MAPK14,MAPK13,MAP2K3,DERL1,TOMM40L,BAX,PPP3CB,PPP3CC,CASP1,CASP12,BCL2L1,GRIN2D,GPX1
ko05014	Amyotrophic lateral sclerosis (ALS)	0.122659476910263	-2.09834324334367	51	48	0.00761904761904762	6300	7161	4741,7133,7132,836,6647,9973,2905,4747,4842,5534,5600,5608,10452,7124,5868,842,54205,1616,57679,2904,5630,596,847,2891,6506,5530,5535,4217,7157,317,6300,2890,2903,4744,5603,5879,1432,84134,581,79139,5606,598,2876,2906,5533,5532,834,100506742	NEFM,TNFRSF1B,TNFRSF1A,CASP3,SOD1,CCS,GRIN2C,NEFL,NOS1,PPP3R1,MAPK11,MAP2K6,TOMM40,TNF,RAB5A,CASP9,CYCS,DAXX,ALS2,GRIN2B,PRPH,BCL2,CAT,GRIA2,SLC1A2,PPP3CA,PPP3R2,MAP3K5,TP53,APAF1,MAPK12,GRIA1,GRIN2A,NEFH,MAPK13,RAC1,MAPK14,TOMM40L,BAX,DERL1,MAP2K3,BCL2L1,GPX1,GRIN2D,PPP3CC,PPP3CB,CASP1,CASP12
ko05152	Tuberculosis	0.124046554261137	-2.08709834624634	178	162	0.0257142857142857	6300	7161	5869,3452,3593,3592,4790,5601,387,3587,3689,4800,207,8717,5289,3119,6714,3553,3552,26253,3117,929,581,1520,3687,3716,2214,2207,10892,30835,3439,3113,3112,1432,817,3459,1387,91860,7040,7879,5894,1378,1509,1054,4615,2215,820,6300,10332,8767,8625,2209,3441,841,9103,3458,7096,6850,2033,9114,4802,50617,51135,5535,5595,5994,3329,808,163688,1263,54205,3916,810,818,3445,64581,596,5534,5594,54106,245972,56848,3118,815,3929,7043,7042,5868,7124,805,3588,10000,836,3444,51806,6772,1051,208,3111,3108,535,816,972,9902,533,5532,5533,3586,3123,3122,3717,3606,3443,3442,4360,843,11151,10312,3656,5603,8772,5602,51606,3460,5599,8877,3449,8915,317,801,3127,23545,5970,3456,5993,3569,5878,1594,7097,718,22925,5530,3684,3313,10333,7421,7099,3440,3448,1385,5600,23365,4046,842,3109,4261,4801,64127,7189,8411,114609,2212,2213,7132	RAB5B,IFNA21,IL12B,IL12A,NFKB1,MAPK9,RHOA,IL10RA,ITGB2,NFYA,AKT1,TRADD,PIK3C3,HLA-DQB1,SRC,IL1B,IL1A,CLEC4E,HLA-DQA1,CD14,BAX,CTSS,ITGAX,JAK1,FCGR3A,FCER1G,MALT1,CD209,IFNA1,HLA-DPA1,HLA-DOB,MAPK14,CAMK2D,IFNGR1,CREBBP,CALML4,TGFB1,RAB7A,RAF1,CR1,CTSD,CEBPG,MYD88,FCGR3B,CAMP,MAPK12,CLEC4M,RIPK2,RFXANK,FCGR1A,IFNA4,CASP8,FCGR2C,IFNG,TLR1,SYK,EP300,ATP6V0D1,NFYC,ATP6V0A4,IRAK4,PPP3R2,MAPK3,RFXAP,HSPD1,CALM3,CALML6,PLK3,CYCS,LAMP1,CALML3,CAMK2G,IFNA8,CLEC7A,BCL2,PPP3R1,MAPK1,TLR9,ATP6V0D2,SPHK2,HLA-DQA2,CAMK2A,LBP,TGFB3,TGFB2,RAB5A,TNF,CALM2,IL10RB,AKT3,CASP3,IFNA7,CALML5,STAT1,CEBPB,AKT2,HLA-DOA,HLA-DMA,ATP6V0A1,CAMK2B,CD74,MRC2,ATP6V0B,PPP3CB,PPP3CC,IL10,HLA-DRB1,HLA-DRA,JAK2,IL18,IFNA6,IFNA5,MRC1,CASP10,CORO1A,TCIRG1,IRAK2,MAPK13,FADD,MAPK10,ATP6V1H,IFNGR2,MAPK8,SPHK1,IFNA16,BCL10,APAF1,CALM1,HLA-DRB5,ATP6V0A2,RELA,IFNB1,RFX5,IL6,RAB5C,CYP27B1,TLR2,C3,PLA2R1,PPP3CA,ITGAM,HSPA9,TLR6,VDR,TLR4,IFNA2,IFNA14,CREB1,MAPK11,ARHGEF12,LSP1,CASP9,HLA-DMB,CIITA,NFYB,NOD2,TRAF6,EEA1,TIRAP,FCGR2A,FCGR2B,TNFRSF1A
hsa05152	Tuberculosis	0.124046554261137	-2.08709834624634	178	162	0.0257142857142857	6300	7161	718,3684,5530,22925,1594,7097,5878,3569,1385,3448,3440,7099,10333,3313,7421,4261,114609,7189,4801,8411,64127,842,3109,4046,23365,5600,7132,2213,2212,5533,9902,533,5532,3122,3123,3586,972,535,3111,3108,816,10312,11151,3442,3443,4360,843,3606,3717,5599,8877,3460,5602,51606,3656,8772,5603,5970,23545,5993,3456,801,3127,8915,317,3449,51135,5595,5535,9114,4802,50617,2033,6850,3458,9103,841,7096,596,818,64581,3445,54205,1263,810,3916,808,3329,163688,5994,805,5868,7042,3929,7043,7124,815,3118,54106,5594,5534,56848,245972,208,51806,1051,6772,3444,10000,836,3588,6714,3119,207,8717,5289,3552,3553,3689,4800,5601,4790,3587,387,5869,3592,3593,3452,2214,3716,1520,3687,26253,581,3117,929,5894,7879,1378,3459,1387,1432,817,7040,91860,3439,3112,3113,10892,2207,30835,8767,3441,2209,8625,10332,1509,1054,6300,4615,2215,820	C3,ITGAM,PPP3CA,PLA2R1,CYP27B1,TLR2,RAB5C,IL6,CREB1,IFNA14,IFNA2,TLR4,TLR6,HSPA9,VDR,CIITA,TIRAP,TRAF6,NFYB,EEA1,NOD2,CASP9,HLA-DMB,LSP1,ARHGEF12,MAPK11,TNFRSF1A,FCGR2B,FCGR2A,PPP3CC,MRC2,ATP6V0B,PPP3CB,HLA-DRA,HLA-DRB1,IL10,CD74,ATP6V0A1,HLA-DOA,HLA-DMA,CAMK2B,TCIRG1,CORO1A,IFNA5,IFNA6,MRC1,CASP10,IL18,JAK2,MAPK8,SPHK1,IFNGR2,MAPK10,ATP6V1H,IRAK2,FADD,MAPK13,RELA,ATP6V0A2,RFX5,IFNB1,CALM1,HLA-DRB5,BCL10,APAF1,IFNA16,IRAK4,MAPK3,PPP3R2,ATP6V0D1,NFYC,ATP6V0A4,EP300,SYK,IFNG,FCGR2C,CASP8,TLR1,BCL2,CAMK2G,CLEC7A,IFNA8,CYCS,PLK3,CALML3,LAMP1,CALM3,HSPD1,CALML6,RFXAP,CALM2,RAB5A,TGFB2,LBP,TGFB3,TNF,CAMK2A,HLA-DQA2,TLR9,MAPK1,PPP3R1,SPHK2,ATP6V0D2,AKT2,CALML5,CEBPB,STAT1,IFNA7,AKT3,CASP3,IL10RB,SRC,HLA-DQB1,AKT1,TRADD,PIK3C3,IL1A,IL1B,ITGB2,NFYA,MAPK9,NFKB1,IL10RA,RHOA,RAB5B,IL12A,IL12B,IFNA21,FCGR3A,JAK1,CTSS,ITGAX,CLEC4E,BAX,HLA-DQA1,CD14,RAF1,RAB7A,CR1,IFNGR1,CREBBP,MAPK14,CAMK2D,TGFB1,CALML4,IFNA1,HLA-DOB,HLA-DPA1,MALT1,FCER1G,CD209,RIPK2,IFNA4,FCGR1A,RFXANK,CLEC4M,CTSD,CEBPG,MAPK12,MYD88,FCGR3B,CAMP
hsa04066	HIF-1 signaling pathway	0.127859594034794	-2.05682253872451	101	93	0.0147619047619048	6300	7161	3630,3091,6194,5290,818,1950,596,4846,3458,2064,2033,5335,5595,5604,4878,10000,7422,208,3480,5594,5605,284,1977,51378,815,3479,3101,7018,7010,5211,2321,50508,1978,5293,3162,3939,1026,3570,4055,2027,5209,80201,4790,6923,207,7428,2023,5336,2475,5161,3459,1387,817,5295,7099,3099,3569,226,7037,405,54583,2056,285,6198,5579,6199,112399,1906,1027,6774,5163,5162,5054,6513,8453,816,2597,3643,2026,9470,5578,9978,5291,3098,2872,5970,5582,8503,6921,1956,3460,5296,112398	INS,HIF1A,RPS6,PIK3CA,CAMK2G,EGF,BCL2,NOS3,IFNG,ERBB2,EP300,PLCG1,MAPK3,MAP2K1,NPPA,AKT3,VEGFA,AKT2,IGF1R,MAPK1,MAP2K2,ANGPT1,EIF4E,ANGPT4,CAMK2A,IGF1,HK3,TF,TEK,PFKL,FLT1,NOX3,EIF4EBP1,PIK3CD,HMOX1,LDHA,CDKN1A,IL6R,LTBR,ENO3,PFKFB3,HKDC1,NFKB1,ELOB,AKT1,VHL,ENO1,PLCG2,MTOR,PDHA2,IFNGR1,CREBBP,CAMK2D,PIK3R1,TLR4,HK2,IL6,ALDOA,TFRC,ARNT,EGLN1,EPO,ANGPT2,RPS6KB1,PRKCB,RPS6KB2,EGLN3,EDN1,CDKN1B,STAT3,PDK1,PDHB,SERPINE1,SLC2A1,CUL2,CAMK2B,GAPDH,INSR,ENO2,EIF4E2,PRKCA,RBX1,PIK3CB,HK1,MKNK2,RELA,PRKCG,PIK3R3,ELOC,EGFR,IFNGR2,PIK3R2,EGLN2
M00099	Sphingosine biosynthesis	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	253782,125981,123099,56624,204219,427,9517,340485,91012,55304,10715,79603,8560,2531,29956,10558	CERS6,ACER1,DEGS2,ASAH2,CERS3,ASAH1,SPTLC2,ACER2,CERS5,SPTLC3,CERS1,CERS4,DEGS1,KDSR,CERS2,SPTLC1
hsa_M00695	cAMP signaling	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	5567,113,107,109,5566,115,112,196883,5568,114,111,108,2771,2773,2770,2778	PRKACB,ADCY7,ADCY1,ADCY3,PRKACA,ADCY9,ADCY6,ADCY4,PRKACG,ADCY8,ADCY5,ADCY2,GNAI2,GNAI3,GNAI1,GNAS
M00683	Hippo signaling	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	25937,7004,6788,79981,9113,92597,60485,7005,4771,10413,7003,55233,8463,122786,26524,23286	WWTR1,TEAD4,STK3,FRMD1,LATS1,MOB1B,SAV1,TEAD3,NF2,YAP1,TEAD1,MOB1A,TEAD2,FRMD6,LATS2,WWC1
hsa_M00683	Hippo signaling	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	8463,55233,122786,26524,23286,6788,25937,7004,60485,92597,7005,4771,10413,7003,9113,79981	TEAD2,MOB1A,FRMD6,LATS2,WWC1,STK3,WWTR1,TEAD4,SAV1,MOB1B,TEAD3,NF2,YAP1,TEAD1,LATS1,FRMD1
hsa_M00295	BRCA1-associated genome surveillance complex (BASC)	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	5395,4292,672,5984,5985,5982,5111,5983,5981,4436,10111,2956,472,4361,641,4683	PMS2,MLH1,BRCA1,RFC4,RFC5,RFC2,PCNA,RFC3,RFC1,MSH2,RAD50,MSH6,ATM,MRE11,BLM,NBN
M00295	BRCA1-associated genome surveillance complex (BASC)	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	4292,672,5984,5395,5981,4436,5985,5982,5111,5983,2956,10111,641,4683,472,4361	MLH1,BRCA1,RFC4,PMS2,RFC1,MSH2,RFC5,RFC2,PCNA,RFC3,MSH6,RAD50,BLM,NBN,ATM,MRE11
hsa_M00099	Sphingosine biosynthesis	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	10558,29956,2531,8560,79603,10715,55304,340485,91012,9517,427,204219,56624,123099,253782,125981	SPTLC1,CERS2,KDSR,DEGS1,CERS4,CERS1,SPTLC3,ACER2,CERS5,SPTLC2,ASAH1,CERS3,ASAH2,DEGS2,CERS6,ACER1
hsa_M00075	N-glycan biosynthesis, complex type	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	2683,8704,2530,4248,4122,6480,4124,146664,25834,8703,152586,4249,11282,84620,4247,11320	B4GALT1,B4GALT2,FUT8,MGAT3,MAN2A2,ST6GAL1,MAN2A1,MGAT5B,MGAT4C,B4GALT3,MGAT4D,MGAT5,MGAT4B,ST6GAL2,MGAT2,MGAT4A
M00075	N-glycan biosynthesis, complex type	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	84620,11282,11320,4247,6480,4124,4249,25834,152586,8703,146664,8704,2683,2530,4248,4122	ST6GAL2,MGAT4B,MGAT4A,MGAT2,ST6GAL1,MAN2A1,MGAT5,MGAT4C,MGAT4D,B4GALT3,MGAT5B,B4GALT2,B4GALT1,FUT8,MGAT3,MAN2A2
M00695	cAMP signaling	0.128491341058018	-2.05189376167982	16	16	0.00253968253968254	6300	7161	113,5567,115,5566,109,107,5568,114,196883,112,2778,2770,2773,2771,111,108	ADCY7,PRKACB,ADCY9,PRKACA,ADCY3,ADCY1,PRKACG,ADCY8,ADCY4,ADCY6,GNAS,GNAI1,GNAI3,GNAI2,ADCY5,ADCY2
ko05213	Endometrial cancer	0.132599576174198	-2.0204213975085	50	47	0.00746031746031746	6300	7161	324,2932,1499,29119,2885,207,5293,1496,3845,6655,6934,1956,8503,4292,5894,2309,5296,6654,673,3265,5291,4609,595,999,2064,5728,5604,5595,8313,7157,8312,5290,5295,1950,51176,5594,5605,3611,1495,842,4893,10297,10000,6932,5170,208,83439	APC,GSK3B,CTNNB1,CTNNA3,GRB2,AKT1,PIK3CD,CTNNA2,KRAS,SOS2,TCF7L2,EGFR,PIK3R3,MLH1,RAF1,FOXO3,PIK3R2,SOS1,BRAF,HRAS,PIK3CB,MYC,CCND1,CDH1,ERBB2,PTEN,MAP2K1,MAPK3,AXIN2,TP53,AXIN1,PIK3CA,PIK3R1,EGF,LEF1,MAPK1,MAP2K2,ILK,CTNNA1,CASP9,NRAS,APC2,AKT3,TCF7,PDPK1,AKT2,TCF7L1
hsa05213	Endometrial cancer	0.132599576174198	-2.0204213975085	50	47	0.00746031746031746	6300	7161	5605,5594,51176,842,1495,3611,5170,10000,6932,4893,10297,208,83439,5728,2064,7157,8313,8312,5595,5604,5290,5295,1950,8503,4292,1956,5296,5894,2309,3265,5291,673,6654,595,999,4609,2932,1499,29119,324,207,2885,1496,5293,6655,6934,3845	MAP2K2,MAPK1,LEF1,CASP9,CTNNA1,ILK,PDPK1,AKT3,TCF7,NRAS,APC2,AKT2,TCF7L1,PTEN,ERBB2,TP53,AXIN2,AXIN1,MAPK3,MAP2K1,PIK3CA,PIK3R1,EGF,PIK3R3,MLH1,EGFR,PIK3R2,RAF1,FOXO3,HRAS,PIK3CB,BRAF,SOS1,CCND1,CDH1,MYC,GSK3B,CTNNB1,CTNNA3,APC,AKT1,GRB2,CTNNA2,PIK3CD,SOS2,TCF7L2,KRAS
hsa04320	Dorso-ventral axis formation	0.133124401518572	-2.01647123816369	28	27	0.00428571428571429	6300	7161	80315,440822,1956,5594,56907,64506,9271,132864,2120,2114,4855,4853,6654,143689,673,5604,2885,5595,55124,22849,84501,6655,51513,3845,2113,4854,56776	CPEB4,PIWIL3,EGFR,MAPK1,SPIRE1,CPEB1,PIWIL1,CPEB2,ETV6,ETS2,NOTCH4,NOTCH2,SOS1,PIWIL4,BRAF,MAP2K1,GRB2,MAPK3,PIWIL2,CPEB3,SPIRE2,SOS2,ETV7,KRAS,ETS1,NOTCH3,FMN2
ko04320	Dorso-ventral axis formation	0.133124401518572	-2.01647123816369	28	27	0.00428571428571429	6300	7161	84501,5595,2885,5604,22849,55124,2113,4854,56776,51513,6655,3845,1956,440822,56907,5594,80315,6654,143689,673,9271,64506,2120,132864,4855,2114,4853	SPIRE2,MAPK3,GRB2,MAP2K1,CPEB3,PIWIL2,ETS1,NOTCH3,FMN2,ETV7,SOS2,KRAS,EGFR,PIWIL3,SPIRE1,MAPK1,CPEB4,SOS1,PIWIL4,BRAF,PIWIL1,CPEB1,ETV6,CPEB2,NOTCH4,ETS2,NOTCH2
ko04744	Phototransduction	0.133124401518572	-2.01647123816369	28	27	0.00428571428571429	6300	7161	5145,2779,5148,8787,2979,91860,6010,805,1258,801,51806,9187,5158,2782,2780,2978,5957,3000,2792,6011,163688,808,810,131890,1259,6295,9626	PDE6A,GNAT1,PDE6G,RGS9,GUCA1B,CALML4,RHO,CALM2,CNGB1,CALM1,CALML5,SLC24A1,PDE6B,GNB1,GNAT2,GUCA1A,RCVRN,GUCY2D,GNGT1,GRK1,CALML6,CALM3,CALML3,GRK7,CNGA1,SAG,GUCA1C
hsa04744	Phototransduction	0.133124401518572	-2.01647123816369	28	27	0.00428571428571429	6300	7161	6295,9626,1259,131890,810,163688,808,2792,6011,3000,5957,2978,2782,5158,2780,51806,801,9187,1258,805,2979,6010,91860,2779,5148,8787,5145	SAG,GUCA1C,CNGA1,GRK7,CALML3,CALML6,CALM3,GNGT1,GRK1,GUCY2D,RCVRN,GUCA1A,GNB1,PDE6B,GNAT2,CALML5,CALM1,SLC24A1,CNGB1,CALM2,GUCA1B,RHO,CALML4,GNAT1,PDE6G,RGS9,PDE6A
hsa00620	Pyruvate metabolism	0.135756860457324	-1.99688978400622	39	37	0.00587301587301587	6300	7161	217,219,4190,2271,32,92483,5105,160287,10873,197257,5315,4200,5313,5091,98,5162,3939,1738,38,39,55902,3945,3948,2739,223,4191,1737,4199,3029,97,31,501,224,84532,5161,134526,9380	ALDH2,ALDH1B1,MDH1,FH,ACACB,LDHAL6B,PCK1,LDHAL6A,ME3,LDHD,PKM,ME2,PKLR,PC,ACYP2,PDHB,LDHA,DLD,ACAT1,ACAT2,ACSS2,LDHB,LDHC,GLO1,ALDH9A1,MDH2,DLAT,ME1,HAGH,ACYP1,ACACA,ALDH7A1,ALDH3A2,ACSS1,PDHA2,ACOT12,GRHPR
ko00620	Pyruvate metabolism	0.135756860457324	-1.99688978400622	39	37	0.00587301587301587	6300	7161	4200,5315,5091,5313,98,5162,3939,38,1738,10873,197257,2271,32,92483,5105,160287,217,219,4190,5161,134526,9380,224,84532,1737,4199,3029,97,31,501,3945,39,55902,3948,2739,223,4191	ME2,PKM,PC,PKLR,ACYP2,PDHB,LDHA,ACAT1,DLD,ME3,LDHD,FH,ACACB,LDHAL6B,PCK1,LDHAL6A,ALDH2,ALDH1B1,MDH1,PDHA2,ACOT12,GRHPR,ALDH3A2,ACSS1,DLAT,ME1,HAGH,ACYP1,ACACA,ALDH7A1,LDHB,ACAT2,ACSS2,LDHC,GLO1,ALDH9A1,MDH2
hsa04730	Long-term depression	0.136560886589534	-1.99098470820937	60	56	0.00888888888888889	6300	7161	5332,3708,5578,2773,5593,5592,5518,5515,2767,6261,4067,3845,5331,1392,5894,2771,2982,673,23236,2983,3265,2776,2895,2890,5582,5330,123745,1394,2778,2770,5604,5595,5321,2891,2781,100137049,5579,3710,10842,2768,10672,3479,4842,5605,5594,283748,3709,5516,4893,2977,8605,773,2911,255189,3480,5519	PLCB4,ITPR1,PRKCA,GNAI3,PRKG2,PRKG1,PPP2R1A,PPP2CA,GNA11,RYR1,LYN,KRAS,PLCB3,CRH,RAF1,GNAI2,GUCY1A1,BRAF,PLCB1,GUCY1B1,HRAS,GNAQ,GRID2,GRIA1,PRKCG,PLCB2,PLA2G4E,CRHR1,GNAS,GNAI1,MAP2K1,MAPK3,PLA2G4A,GRIA2,GNAZ,PLA2G4B,PRKCB,ITPR3,PPP1R17,GNA12,GNA13,IGF1,NOS1,MAP2K2,MAPK1,PLA2G4D,ITPR2,PPP2CB,NRAS,GUCY1A2,PLA2G4C,CACNA1A,GRM1,PLA2G4F,IGF1R,PPP2R1B
ko04730	Long-term depression	0.136560886589534	-1.99098470820937	60	56	0.00888888888888889	6300	7161	3708,5332,5593,2773,5592,5578,6261,4067,2767,5518,5515,3845,5331,2771,1392,5894,3265,2776,673,2982,2983,23236,5582,2895,2890,1394,123745,5330,2770,2778,5604,5595,5321,100137049,2891,2781,4842,5594,5605,10672,2768,3479,3710,5579,10842,3709,5516,283748,8605,4893,2977,3480,5519,773,2911,255189	ITPR1,PLCB4,PRKG2,GNAI3,PRKG1,PRKCA,RYR1,LYN,GNA11,PPP2R1A,PPP2CA,KRAS,PLCB3,GNAI2,CRH,RAF1,HRAS,GNAQ,BRAF,GUCY1A1,GUCY1B1,PLCB1,PRKCG,GRID2,GRIA1,CRHR1,PLA2G4E,PLCB2,GNAI1,GNAS,MAP2K1,MAPK3,PLA2G4A,PLA2G4B,GRIA2,GNAZ,NOS1,MAPK1,MAP2K2,GNA13,GNA12,IGF1,ITPR3,PRKCB,PPP1R17,ITPR2,PPP2CB,PLA2G4D,PLA2G4C,NRAS,GUCY1A2,IGF1R,PPP2R1B,CACNA1A,GRM1,PLA2G4F
hsa04970	Salivary secretion	0.137001100702884	-1.98776631885866	90	83	0.0131746031746032	6300	7161	276,153,91860,1470,3347,476,5568,481,5331,112,4589,155,3346,490,5582,154,801,653247,6263,6522,820,2982,23236,2983,2776,477,5578,4069,5593,482,5592,111,6558,5332,683,3708,493,5542,107,1755,486,6548,148,54831,805,3709,1469,1472,108,362,1473,5579,3710,4842,147,196883,4025,483,478,3778,1131,952,51806,2977,6844,1471,2778,727897,146,5330,114,55503,480,115,491,5566,109,810,113,5567,163688,808,6779	AMY1A,ADRB1,CALML4,CST2,HTN3,ATP1A1,PRKACG,ATP1B1,PLCB3,ADCY6,MUC7,ADRB3,HTN1,ATP2B1,PRKCG,ADRB2,CALM1,PRB2,RYR3,SLC4A2,CAMP,GUCY1A1,PLCB1,GUCY1B1,GNAQ,ATP1A2,PRKCA,LYZ,PRKG2,ATP1B2,PRKG1,ADCY5,SLC12A2,PLCB4,BST1,ITPR1,ATP2B4,PRB1,ADCY1,DMBT1,FXYD2,SLC9A1,ADRA1A,BEST2,CALM2,ITPR2,CST1,CST4,ADCY2,AQP5,CST5,PRKCB,ITPR3,NOS1,ADRA1B,ADCY4,LPO,ATP1B3,ATP1A3,KCNMA1,CHRM3,CD38,CALML5,GUCY1A2,VAMP2,CST3,GNAS,MUC5B,ADRA1D,PLCB2,ADCY8,TRPV6,ATP1A4,ADCY9,ATP2B2,PRKACA,ADCY3,CALML3,ADCY7,PRKACB,CALML6,CALM3,STATH
ko04970	Salivary secretion	0.137001100702884	-1.98776631885866	90	83	0.0131746031746032	6300	7161	2778,1471,727897,146,5330,114,55503,480,115,5566,491,109,810,808,5567,163688,113,6779,54831,805,3709,1472,362,108,1469,1473,3710,5579,147,4842,196883,4025,483,478,3778,1131,952,51806,2977,6844,477,4069,5578,5593,482,5592,111,6558,5332,683,3708,493,5542,107,1755,486,6548,148,276,153,91860,1470,3347,476,5568,481,5331,112,3346,4589,155,490,5582,154,801,653247,6263,6522,820,2982,23236,2983,2776	GNAS,CST3,MUC5B,ADRA1D,PLCB2,ADCY8,TRPV6,ATP1A4,ADCY9,PRKACA,ATP2B2,ADCY3,CALML3,CALM3,PRKACB,CALML6,ADCY7,STATH,BEST2,CALM2,ITPR2,CST4,AQP5,ADCY2,CST1,CST5,ITPR3,PRKCB,ADRA1B,NOS1,ADCY4,LPO,ATP1B3,ATP1A3,KCNMA1,CHRM3,CD38,CALML5,GUCY1A2,VAMP2,ATP1A2,LYZ,PRKCA,PRKG2,ATP1B2,PRKG1,ADCY5,SLC12A2,PLCB4,BST1,ITPR1,ATP2B4,PRB1,ADCY1,DMBT1,FXYD2,SLC9A1,ADRA1A,AMY1A,ADRB1,CALML4,CST2,HTN3,ATP1A1,PRKACG,ATP1B1,PLCB3,ADCY6,HTN1,MUC7,ADRB3,ATP2B1,PRKCG,ADRB2,CALM1,PRB2,RYR3,SLC4A2,CAMP,GUCY1A1,PLCB1,GUCY1B1,GNAQ
hsa05144	Malaria	0.143223657263584	-1.94334783374569	49	46	0.0073015873015873	6300	7161	54106,3043,2994,6347,7124,7042,7043,6403,5175,6383,3820,3576,6382,975,3082,7057,100528032,3569,2995,3458,7097,7060,7099,6401,22914,1311,3039,7412,7059,3683,4233,1378,7040,948,4615,7058,2532,3383,958,3592,2993,3586,3553,4035,3689,3606	TLR9,HBB,GYPB,CCL2,TNF,TGFB2,TGFB3,SELP,PECAM1,SDC2,KLRB1,CXCL8,SDC1,CD81,HGF,THBS1,KLRC4-KLRK1,IL6,GYPC,IFNG,TLR2,THBS4,TLR4,SELE,KLRK1,COMP,HBA1,VCAM1,THBS3,ITGAL,MET,CR1,TGFB1,CD36,MYD88,THBS2,ACKR1,ICAM1,CD40,IL12A,GYPA,IL10,IL1B,LRP1,ITGB2,IL18
ko05144	Malaria	0.143223657263584	-1.94334783374569	49	46	0.0073015873015873	6300	7161	3043,54106,6347,2994,7043,7042,7124,6403,5175,6382,3576,3820,6383,975,100528032,7057,3082,2995,3458,3569,7097,7099,7060,1311,22914,6401,7412,3039,7059,4233,3683,1378,7040,948,2532,7058,4615,958,3383,2993,3592,4035,3586,3553,3689,3606	HBB,TLR9,CCL2,GYPB,TGFB3,TGFB2,TNF,SELP,PECAM1,SDC1,CXCL8,KLRB1,SDC2,CD81,KLRC4-KLRK1,THBS1,HGF,GYPC,IFNG,IL6,TLR2,TLR4,THBS4,COMP,KLRK1,SELE,VCAM1,HBA1,THBS3,MET,ITGAL,CR1,TGFB1,CD36,ACKR1,THBS2,MYD88,CD40,ICAM1,GYPA,IL12A,LRP1,IL10,IL1B,ITGB2,IL18
M00014	Glucuronate pathway (uronate pathway)	0.147087328154336	-1.91672879951547	27	26	0.00412698412698413	6300	7161	54658,10720,7358,2990,54576,574537,54577,7364,54579,6652,54578,54575,51084,54657,7366,54659,7365,7363,10327,79799,10941,9365,54490,9942,54600,51181	UGT1A1,UGT2B11,UGDH,GUSB,UGT1A8,UGT2A2,UGT1A7,UGT2B7,UGT1A5,SORD,UGT1A6,UGT1A10,CRYL1,UGT1A4,UGT2B15,UGT1A3,UGT2B10,UGT2B4,AKR1A1,UGT2A3,UGT2A1,KL,UGT2B28,XYLB,UGT1A9,DCXR
hsa_M00014	Glucuronate pathway (uronate pathway)	0.147087328154336	-1.91672879951547	27	26	0.00412698412698413	6300	7161	7366,51181,54659,54657,54600,51084,54575,6652,54578,7364,9942,54490,54579,574537,54577,2990,9365,54576,10941,7358,10327,79799,10720,7363,7365,54658	UGT2B15,DCXR,UGT1A3,UGT1A4,UGT1A9,CRYL1,UGT1A10,SORD,UGT1A6,UGT2B7,XYLB,UGT2B28,UGT1A5,UGT2A2,UGT1A7,GUSB,KL,UGT1A8,UGT2A1,UGDH,AKR1A1,UGT2A3,UGT2B11,UGT2B4,UGT2B10,UGT1A1
ko00982	Drug metabolism - cytochrome P450	0.147407755947847	-1.91455268224046	69	64	0.0101587301587302	6300	7161	316,1557,220,54578,130,4257,574537,4259,128,7364,1559,2953,2952,1565,54658,2328,221357,2941,2949,119391,125,9446,124,2947,79799,7365,2946,2939,54657,373156,2948,2940,7366,54659,1577,222,1544,54575,126,1576,54577,54579,2938,54576,2950,10720,27306,2326,127,218,1548,54600,131,2327,2330,221,2944,54490,10941,2329,4258,1555,1558,7363	AOX1,CYP2C19,ALDH1A3,UGT1A6,ADH6,MGST1,UGT2A2,MGST3,ADH5,UGT2B7,CYP2C9,GSTT2,GSTT1,CYP2D6,UGT1A1,FMO3,GSTA5,GSTA4,GSTM5,GSTO2,ADH1B,GSTO1,ADH1A,GSTM3,UGT2A3,UGT2B10,GSTM2,GSTA2,UGT1A4,GSTK1,GSTM4,GSTA3,UGT2B15,UGT1A3,CYP3A5,ALDH3B2,CYP1A2,UGT1A10,ADH1C,CYP3A4,UGT1A7,UGT1A5,GSTA1,UGT1A8,GSTP1,UGT2B11,HPGDS,FMO1,ADH4,ALDH3A1,CYP2A6,UGT1A9,ADH7,FMO2,FMO5,ALDH3B1,GSTM1,UGT2B28,UGT2A1,FMO4,MGST2,CYP2B6,CYP2C8,UGT2B4
hsa00982	Drug metabolism - cytochrome P450	0.147407755947847	-1.91455268224046	69	64	0.0101587301587302	6300	7161	2948,373156,54657,2940,7366,54659,222,1577,1544,126,54575,1576,54577,54579,2938,54576,2950,10720,2326,27306,127,218,1548,54600,131,2327,2330,2944,221,54490,10941,2329,4258,1555,1558,7363,316,1557,220,54578,130,4257,574537,4259,128,7364,1559,2953,2952,1565,54658,2328,221357,2941,2949,119391,125,9446,2947,124,79799,7365,2946,2939	GSTM4,GSTK1,UGT1A4,GSTA3,UGT2B15,UGT1A3,ALDH3B2,CYP3A5,CYP1A2,ADH1C,UGT1A10,CYP3A4,UGT1A7,UGT1A5,GSTA1,UGT1A8,GSTP1,UGT2B11,FMO1,HPGDS,ADH4,ALDH3A1,CYP2A6,UGT1A9,ADH7,FMO2,FMO5,GSTM1,ALDH3B1,UGT2B28,UGT2A1,FMO4,MGST2,CYP2B6,CYP2C8,UGT2B4,AOX1,CYP2C19,ALDH1A3,UGT1A6,ADH6,MGST1,UGT2A2,MGST3,ADH5,UGT2B7,CYP2C9,GSTT2,GSTT1,CYP2D6,UGT1A1,FMO3,GSTA5,GSTA4,GSTM5,GSTO2,ADH1B,GSTO1,GSTM3,ADH1A,UGT2A3,UGT2B10,GSTM2,GSTA2
ko00140	Steroid hormone biosynthesis	0.1570839044937	-1.85097519286047	58	54	0.00857142857142857	6300	7161	8630,1109,10720,7923,54579,3284,54577,54576,54575,6716,1544,1576,3290,54659,7366,1585,54657,1588,1577,7363,100861540,54490,1645,10941,79644,1584,3294,8644,1312,54600,1545,51478,6783,54658,7364,574537,1646,3292,3293,51144,54578,1583,79799,1586,3283,7365,6715,6718,9420,1589,3291,6820,1581,1543	HSD17B6,AKR1C4,UGT2B11,HSD17B8,UGT1A5,HSD3B2,UGT1A7,UGT1A8,UGT1A10,SRD5A2,CYP1A2,CYP3A4,HSD11B1,UGT1A3,UGT2B15,CYP11B2,UGT1A4,CYP19A1,CYP3A5,UGT2B4,CYP3A7-CYP3A51P,UGT2B28,AKR1C1,UGT2A1,SRD5A3,CYP11B1,HSD17B2,AKR1C3,COMT,UGT1A9,CYP1B1,HSD17B7,SULT1E1,UGT1A1,UGT2B7,UGT2A2,AKR1C2,HSD17B1,HSD17B3,HSD17B12,UGT1A6,CYP11A1,UGT2A3,CYP17A1,HSD3B1,UGT2B10,SRD5A1,AKR1D1,CYP7B1,CYP21A2,HSD11B2,SULT2B1,CYP7A1,CYP1A1
hsa00140	Steroid hormone biosynthesis	0.1570839044937	-1.85097519286047	58	54	0.00857142857142857	6300	7161	9420,1589,3291,6820,1581,1543,79799,1586,3283,7365,6715,6718,1646,3292,51144,3293,54578,1583,54658,6783,7364,574537,1584,3294,8644,1312,54600,1545,51478,7363,100861540,54490,1645,10941,79644,54575,6716,1544,1576,3290,54659,7366,1585,54657,1588,1577,8630,1109,10720,7923,54579,3284,54577,54576	CYP7B1,CYP21A2,HSD11B2,SULT2B1,CYP7A1,CYP1A1,UGT2A3,CYP17A1,HSD3B1,UGT2B10,SRD5A1,AKR1D1,AKR1C2,HSD17B1,HSD17B12,HSD17B3,UGT1A6,CYP11A1,UGT1A1,SULT1E1,UGT2B7,UGT2A2,CYP11B1,HSD17B2,AKR1C3,COMT,UGT1A9,CYP1B1,HSD17B7,UGT2B4,CYP3A7-CYP3A51P,UGT2B28,AKR1C1,UGT2A1,SRD5A3,UGT1A10,SRD5A2,CYP1A2,CYP3A4,HSD11B1,UGT1A3,UGT2B15,CYP11B2,UGT1A4,CYP19A1,CYP3A5,HSD17B6,AKR1C4,UGT2B11,HSD17B8,UGT1A5,HSD3B2,UGT1A7,UGT1A8
hsa05031	Amphetamine addiction	0.157257000563512	-1.84987386570564	68	63	0.01	6300	7161	64764,805,5534,6531,84152,5579,815,51806,2905,814,116443,2893,775,5500,5535,1644,2778,5530,3725,6570,2891,5566,116444,2354,818,1388,1385,90993,3065,808,163688,5567,148327,2904,810,23411,91860,5499,817,84699,6571,1386,10488,5568,801,2890,5582,2903,1812,5173,23237,2353,111,5578,5532,5533,9586,816,2906,7054,468,5501,776	CREB3L2,CALM2,PPP3R1,SLC6A3,PPP1R1B,PRKCB,CAMK2A,CALML5,GRIN2C,CAMK4,GRIN3A,GRIA4,CACNA1C,PPP1CB,PPP3R2,DDC,GNAS,PPP3CA,JUN,SLC18A1,GRIA2,PRKACA,GRIN3B,FOSB,CAMK2G,ATF6B,CREB1,CREB3L1,HDAC1,CALM3,CALML6,PRKACB,CREB3L4,GRIN2B,CALML3,SIRT1,CALML4,PPP1CA,CAMK2D,CREB3L3,SLC18A2,ATF2,CREB3,PRKACG,CALM1,GRIA1,PRKCG,GRIN2A,DRD1,PDYN,ARC,FOS,ADCY5,PRKCA,PPP3CB,PPP3CC,CREB5,CAMK2B,GRIN2D,TH,ATF4,PPP1CC,CACNA1D
ko05031	Amphetamine addiction	0.157257000563512	-1.84987386570564	68	63	0.01	6300	7161	801,2890,5582,2903,1812,5173,23237,2353,91860,5499,817,84699,6571,1386,10488,5568,7054,468,5501,776,111,5578,5532,5533,9586,816,2906,51806,2905,814,116443,2893,775,5500,64764,805,5534,6531,84152,5579,815,5566,2891,116444,2354,818,1388,90993,3065,1385,163688,5567,808,148327,2904,810,23411,2778,1644,5535,3725,5530,6570	CALM1,GRIA1,PRKCG,GRIN2A,DRD1,PDYN,ARC,FOS,CALML4,PPP1CA,CAMK2D,CREB3L3,SLC18A2,ATF2,CREB3,PRKACG,TH,ATF4,PPP1CC,CACNA1D,ADCY5,PRKCA,PPP3CB,PPP3CC,CREB5,CAMK2B,GRIN2D,CALML5,GRIN2C,CAMK4,GRIN3A,GRIA4,CACNA1C,PPP1CB,CREB3L2,CALM2,PPP3R1,SLC6A3,PPP1R1B,PRKCB,CAMK2A,PRKACA,GRIA2,GRIN3B,FOSB,CAMK2G,ATF6B,CREB3L1,HDAC1,CREB1,CALML6,PRKACB,CALM3,CREB3L4,GRIN2B,CALML3,SIRT1,GNAS,DDC,PPP3R2,JUN,PPP3CA,SLC18A1
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	0.157257000563512	-1.84987386570564	68	63	0.01	6300	7161	2919,3577,526,836,1147,155066,3576,5803,1445,245972,90423,5600,5781,3579,127124,51382,6352,1839,5335,4792,9020,50617,9114,7082,9550,3725,83700,6300,5058,5336,5970,23545,5603,51606,6868,5602,150084,4233,58494,5599,1956,5879,102,1432,3551,528,8992,6416,525,4067,10392,245973,523,529,28964,10312,535,50848,4790,5601,998,533,6714	CXCL1,CXCR1,ATP6V1B2,CASP3,CHUK,ATP6V0E2,CXCL8,PTPRZ1,CSK,ATP6V0D2,ATP6V1E2,MAPK11,PTPN11,CXCR2,ATP6V1G3,ATP6V1D,CCL5,HBEGF,PLCG1,NFKBIA,MAP3K14,ATP6V0A4,ATP6V0D1,TJP1,ATP6V1G1,JUN,JAM3,MAPK12,PAK1,PLCG2,RELA,ATP6V0A2,MAPK13,ATP6V1H,ADAM17,MAPK10,IGSF5,MET,JAM2,MAPK8,EGFR,RAC1,ADAM10,MAPK14,IKBKB,ATP6V1C1,ATP6V0E1,MAP2K4,ATP6V1B1,LYN,NOD1,ATP6V1C2,ATP6V1A,ATP6V1E1,GIT1,TCIRG1,ATP6V0A1,F11R,NFKB1,MAPK9,CDC42,ATP6V0B,SRC
ko05120	Epithelial cell signaling in Helicobacter pylori infection	0.157257000563512	-1.84987386570564	68	63	0.01	6300	7161	127124,3579,90423,245972,5600,5781,155066,1147,5803,3576,1445,2919,3577,836,526,50617,9114,7082,9550,3725,83700,1839,6352,4792,5335,9020,51382,102,5879,3551,1432,528,6416,8992,5602,51606,6868,5603,150084,4233,58494,5599,1956,5336,23545,5970,6300,5058,998,6714,533,535,50848,5601,4790,245973,529,523,10312,28964,525,10392,4067	ATP6V1G3,CXCR2,ATP6V1E2,ATP6V0D2,MAPK11,PTPN11,ATP6V0E2,CHUK,PTPRZ1,CXCL8,CSK,CXCL1,CXCR1,CASP3,ATP6V1B2,ATP6V0A4,ATP6V0D1,TJP1,ATP6V1G1,JUN,JAM3,HBEGF,CCL5,NFKBIA,PLCG1,MAP3K14,ATP6V1D,ADAM10,RAC1,IKBKB,MAPK14,ATP6V1C1,MAP2K4,ATP6V0E1,MAPK10,ATP6V1H,ADAM17,MAPK13,IGSF5,MET,JAM2,MAPK8,EGFR,PLCG2,ATP6V0A2,RELA,MAPK12,PAK1,CDC42,SRC,ATP6V0B,ATP6V0A1,F11R,MAPK9,NFKB1,ATP6V1C2,ATP6V1E1,ATP6V1A,TCIRG1,GIT1,ATP6V1B1,NOD1,LYN
hsa05164	Influenza A	0.160424875145202	-1.82992951362105	172	156	0.0247619047619048	6300	7161	51135,5604,5595,4938,2033,4793,3267,4792,3458,6352,3661,3445,5290,54205,3627,5340,7124,29107,440275,3118,56649,7416,5594,5605,5371,208,6772,6773,10000,64135,3444,8743,207,3838,3119,3553,8794,3552,834,4790,5601,5610,355,3593,3452,3592,90865,390748,5606,10379,3716,5293,4599,3117,6416,5894,5045,7113,1432,3459,1387,3439,3113,29110,3112,9451,8795,4939,7514,1965,3337,3441,29108,4928,3665,3383,84000,148022,4615,6300,3725,57506,3455,3569,4940,10625,3304,103,3448,3440,7099,5295,8797,3312,4261,6347,10482,3454,10898,3109,842,5579,5644,60,5600,5608,5611,356,8793,8106,3576,7706,7132,3305,3836,3123,3122,5578,23586,3306,5609,3111,3108,2932,6041,91543,3443,3442,11100,100529063,3717,3606,3310,3551,5296,114548,7297,3460,5599,9641,71,8503,9021,1386,5603,5602,5970,7098,27102,3456,79671,3127,2224,5646,5291,3449	IRAK4,MAP2K1,MAPK3,OAS1,EP300,NFKBIB,AGFG1,NFKBIA,IFNG,CCL5,IRF3,IFNA8,PIK3CA,CYCS,CXCL10,PLG,TNF,NXT1,EIF2AK4,HLA-DQA2,TMPRSS4,VDAC1,MAPK1,MAP2K2,PML,AKT2,STAT1,STAT2,AKT3,IFIH1,IFNA7,TNFSF10,AKT1,KPNA2,HLA-DQB1,IL1B,TNFRSF10C,IL1A,CASP1,NFKB1,MAPK9,EIF2AK2,FAS,IL12B,IFNA21,IL12A,IL33,PABPN1L,MAP2K3,IRF9,JAK1,PIK3CD,MX1,HLA-DQA1,MAP2K4,RAF1,FURIN,TMPRSS2,MAPK14,IFNGR1,CREBBP,IFNA1,HLA-DPA1,TBK1,HLA-DOB,EIF2AK3,TNFRSF10B,OAS2,XPO1,EIF2S1,DNAJB1,IFNA4,PYCARD,NUP98,IRF7,ICAM1,TMPRSS13,TICAM1,MYD88,MAPK12,JUN,MAVS,IFNAR2,IL6,OAS3,IVNS1ABP,HSPA1B,ADAR,IFNA14,IFNA2,TLR4,PIK3R1,TNFRSF10A,HSPA8,CIITA,CCL2,NXF1,IFNAR1,CPSF4,HLA-DMB,CASP9,PRKCB,PRSS1,ACTB,MAPK11,MAP2K6,DNAJC3,FASLG,TNFRSF10D,PABPN1,CXCL8,TRIM25,TNFRSF1A,HSPA1L,KPNA1,HLA-DRB1,HLA-DRA,PRKCA,RIGI,HSPA2,MAP2K7,HLA-DOA,HLA-DMA,GSK3B,RNASEL,RSAD2,IFNA6,IFNA5,HNRNPUL1,BCL2L2-PABPN1,JAK2,IL18,HSPA6,IKBKB,PIK3R2,NLRP3,TYK2,IFNGR2,MAPK8,IKBKE,ACTG1,PIK3R3,SOCS3,ATF2,MAPK13,MAPK10,RELA,TLR3,EIF2AK1,IFNB1,NLRX1,HLA-DRB5,FDPS,PRSS3,PIK3CB,IFNA16
ko05164	Influenza A	0.160424875145202	-1.82992951362105	172	156	0.0247619047619048	6300	7161	3306,5609,3123,5578,23586,3122,2932,6041,3111,3108,11100,3443,3442,91543,3310,3717,3606,100529063,114548,5296,3551,5603,5602,71,9641,1386,9021,8503,3460,5599,7297,3127,79671,27102,3456,5970,7098,3449,5291,5646,2224,3725,3569,3455,57506,3440,3448,103,3304,10625,4940,3312,8797,7099,5295,842,3109,10898,3454,10482,4261,6347,8106,8793,356,5608,5611,5600,5579,5644,60,3576,3836,3305,7706,7132,834,3553,3552,8794,207,3119,3838,3593,3452,3592,355,4790,5610,5601,3716,10379,390748,5606,90865,3117,4599,5293,1387,3459,1432,7113,6416,5894,5045,4939,8795,29110,3113,9451,3112,3439,3665,3383,29108,4928,1965,3441,3337,7514,4615,6300,84000,148022,4938,5595,5604,51135,6352,3458,4793,3267,4792,2033,3445,3661,5340,5290,54205,3627,7124,5371,7416,5594,5605,56649,440275,3118,29107,6772,6773,208,10000,64135,3444,8743	HSPA2,MAP2K7,HLA-DRB1,PRKCA,RIGI,HLA-DRA,GSK3B,RNASEL,HLA-DOA,HLA-DMA,HNRNPUL1,IFNA6,IFNA5,RSAD2,HSPA6,JAK2,IL18,BCL2L2-PABPN1,NLRP3,PIK3R2,IKBKB,MAPK13,MAPK10,ACTG1,IKBKE,ATF2,SOCS3,PIK3R3,IFNGR2,MAPK8,TYK2,HLA-DRB5,NLRX1,EIF2AK1,IFNB1,RELA,TLR3,IFNA16,PIK3CB,PRSS3,FDPS,JUN,IL6,IFNAR2,MAVS,IFNA2,IFNA14,ADAR,HSPA1B,IVNS1ABP,OAS3,HSPA8,TNFRSF10A,TLR4,PIK3R1,CASP9,HLA-DMB,CPSF4,IFNAR1,NXF1,CIITA,CCL2,PABPN1,TNFRSF10D,FASLG,MAP2K6,DNAJC3,MAPK11,PRKCB,PRSS1,ACTB,CXCL8,KPNA1,HSPA1L,TRIM25,TNFRSF1A,CASP1,IL1B,IL1A,TNFRSF10C,AKT1,HLA-DQB1,KPNA2,IL12B,IFNA21,IL12A,FAS,NFKB1,EIF2AK2,MAPK9,JAK1,IRF9,PABPN1L,MAP2K3,IL33,HLA-DQA1,MX1,PIK3CD,CREBBP,IFNGR1,MAPK14,TMPRSS2,MAP2K4,RAF1,FURIN,OAS2,TNFRSF10B,TBK1,HLA-DPA1,EIF2AK3,HLA-DOB,IFNA1,IRF7,ICAM1,PYCARD,NUP98,EIF2S1,IFNA4,DNAJB1,XPO1,MYD88,MAPK12,TMPRSS13,TICAM1,OAS1,MAPK3,MAP2K1,IRAK4,CCL5,IFNG,NFKBIB,AGFG1,NFKBIA,EP300,IFNA8,IRF3,PLG,PIK3CA,CYCS,CXCL10,TNF,PML,VDAC1,MAPK1,MAP2K2,TMPRSS4,EIF2AK4,HLA-DQA2,NXT1,STAT1,STAT2,AKT2,AKT3,IFIH1,IFNA7,TNFSF10
hsa04020	Calcium signaling pathway	0.161824165848921	-1.82124492921288	181	164	0.026031746031746	6300	7161	5023,7201,6870,1816,2769,1909,3708,2906,493,7134,2066,2767,148,91860,817,135,5257,153,5331,6865,155,5568,80228,5336,487,777,5027,490,3357,886,2776,6262,6263,3274,5535,488,2064,624,3361,5335,5137,114,7125,5261,85366,818,3269,4846,163688,808,5567,291,5731,810,5159,3709,4638,805,5724,6546,2065,6915,185,90550,56848,5534,7416,147,2774,815,4923,51806,773,2905,5153,779,489,1131,91807,80271,775,3973,8912,8913,3707,1910,5578,5532,57105,5533,1129,816,5332,553,5333,887,2915,107,340156,83447,6261,776,93129,5021,10105,3360,8877,1956,3356,154,801,5582,2185,2903,1812,23236,6786,5026,146,5350,6869,5025,2778,5136,5530,136,5156,57620,5330,5737,5566,491,1133,109,115,89869,9630,113,8911,6543,623,1128,108,7417,84812,84876,3362,4842,3363,196883,5579,3710,5024,6547,952,51196,814,2911,3706,2149,5733,1139,7419,552	P2RX1,TRHR,TACR3,DRD5,GNA15,EDNRA,ITPR1,GRIN2D,ATP2B4,TNNC1,ERBB4,GNA11,ADRA1A,CALML4,CAMK2D,ADORA2A,PHKB,ADRB1,PLCB3,TACR2,ADRB3,PRKACG,ORAI2,PLCG2,ATP2A1,CACNA1E,P2RX7,ATP2B1,HTR2B,CCKAR,GNAQ,RYR2,RYR3,HRH2,PPP3R2,ATP2A2,ERBB2,BDKRB2,HTR5A,PLCG1,PDE1C,ADCY8,TNNC2,PHKG2,MYLK2,CAMK2G,HRH1,NOS3,CALML6,CALM3,PRKACB,SLC25A4,PTGER1,CALML3,PDGFRB,ITPR2,MYLK,CALM2,PTAFR,SLC8A1,ERBB3,TBXA2R,AGTR1,MCU,SPHK2,PPP3R1,VDAC1,ADRA1B,GNAL,CAMK2A,NTSR1,CALML5,CACNA1A,GRIN2C,PDE1B,CACNA1S,ATP2A3,CHRM3,MYLK3,ITPKC,CACNA1C,LHCGR,CACNA1H,CACNA1G,ITPKB,EDNRB,PRKCA,PPP3CB,CYSLTR2,PPP3CC,CHRM2,CAMK2B,PLCB4,AVPR1B,PLCD1,CCKBR,GRM5,ADCY1,MYLK4,SLC25A31,RYR1,CACNA1D,ORAI3,OXTR,PPIF,HTR4,SPHK1,EGFR,HTR2A,ADRB2,CALM1,PRKCG,PTK2B,GRIN2A,DRD1,PLCB1,STIM1,P2RX5,ADRA1D,PLN,TACR1,P2RX4,GNAS,PDE1A,PPP3CA,ADORA2B,PDGFRA,STIM2,PLCB2,PTGFR,PRKACA,ATP2B2,CHRM5,ADCY3,ADCY9,PLCZ1,GNA14,ADCY7,CACNA1I,SLC8A2,BDKRB1,CHRM1,ADCY2,VDAC2,PLCD4,ORAI1,HTR6,NOS1,HTR7,ADCY4,PRKCB,ITPR3,P2RX3,SLC8A3,CD38,PLCE1,CAMK4,GRM1,ITPKA,F2R,PTGER3,CHRNA7,VDAC3,AVPR1A
ko04020	Calcium signaling pathway	0.161824165848921	-1.82124492921288	181	164	0.026031746031746	6300	7161	5733,1139,2149,7419,552,952,51196,3706,814,2911,3362,4842,3363,196883,6547,5579,3710,5024,108,7417,1128,84812,84876,8911,6543,113,9630,623,109,491,5566,1133,89869,115,57620,5156,5737,5330,5025,5350,146,6869,2778,5136,5530,136,1812,23236,5026,6786,801,3356,154,5582,2185,2903,3360,1956,8877,10105,5021,93129,6261,83447,776,107,340156,887,2915,1129,816,553,5332,5333,57105,5532,5533,1910,5578,3973,91807,775,80271,3707,8912,8913,51806,4923,1131,773,2905,5153,779,489,7416,5534,147,2774,90550,56848,815,4638,3709,6915,6546,185,2065,805,5724,291,808,5567,163688,5159,5731,810,3269,818,5261,85366,4846,2064,624,114,7125,3361,5335,5137,5535,488,886,2776,3357,3274,6262,6263,5336,80228,487,777,490,5027,155,6865,5331,5568,135,817,91860,153,5257,148,2767,2066,7134,2906,493,1909,3708,7201,6870,5023,2769,1816	PTGER3,CHRNA7,F2R,VDAC3,AVPR1A,CD38,PLCE1,ITPKA,CAMK4,GRM1,HTR6,NOS1,HTR7,ADCY4,SLC8A3,PRKCB,ITPR3,P2RX3,ADCY2,VDAC2,CHRM1,PLCD4,ORAI1,CACNA1I,SLC8A2,ADCY7,GNA14,BDKRB1,ADCY3,ATP2B2,PRKACA,CHRM5,PLCZ1,ADCY9,STIM2,PDGFRA,PTGFR,PLCB2,P2RX4,PLN,ADRA1D,TACR1,GNAS,PDE1A,PPP3CA,ADORA2B,DRD1,PLCB1,P2RX5,STIM1,CALM1,HTR2A,ADRB2,PRKCG,PTK2B,GRIN2A,HTR4,EGFR,SPHK1,PPIF,OXTR,ORAI3,RYR1,SLC25A31,CACNA1D,ADCY1,MYLK4,CCKBR,GRM5,CHRM2,CAMK2B,AVPR1B,PLCB4,PLCD1,CYSLTR2,PPP3CB,PPP3CC,EDNRB,PRKCA,LHCGR,MYLK3,CACNA1C,ITPKC,ITPKB,CACNA1H,CACNA1G,CALML5,NTSR1,CHRM3,CACNA1A,GRIN2C,PDE1B,CACNA1S,ATP2A3,VDAC1,PPP3R1,ADRA1B,GNAL,MCU,SPHK2,CAMK2A,MYLK,ITPR2,TBXA2R,SLC8A1,AGTR1,ERBB3,CALM2,PTAFR,SLC25A4,CALM3,PRKACB,CALML6,PDGFRB,PTGER1,CALML3,HRH1,CAMK2G,PHKG2,MYLK2,NOS3,ERBB2,BDKRB2,ADCY8,TNNC2,HTR5A,PLCG1,PDE1C,PPP3R2,ATP2A2,CCKAR,GNAQ,HTR2B,HRH2,RYR2,RYR3,PLCG2,ORAI2,ATP2A1,CACNA1E,ATP2B1,P2RX7,ADRB3,TACR2,PLCB3,PRKACG,ADORA2A,CAMK2D,CALML4,ADRB1,PHKB,ADRA1A,GNA11,ERBB4,TNNC1,GRIN2D,ATP2B4,EDNRA,ITPR1,TRHR,TACR3,P2RX1,GNA15,DRD5
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate	0.166104346582106	-1.79513909423986	14	14	0.00222222222222222	6300	7161	6389,4967,1738,4190,4191,6390,8802,2271,8803,1743,55753,6392,6391,8801	SDHA,OGDH,DLD,MDH1,MDH2,SDHB,SUCLG1,FH,SUCLA2,DLST,OGDHL,SDHD,SDHC,SUCLG2
hsa_M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate	0.166104346582106	-1.79513909423986	14	14	0.00222222222222222	6300	7161	1738,6389,4967,6391,8801,6390,8802,2271,8803,55753,1743,6392,4191,4190	DLD,SDHA,OGDH,SDHC,SUCLG2,SDHB,SUCLG1,FH,SUCLA2,OGDHL,DLST,SDHD,MDH2,MDH1
hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	0.166104346582106	-1.79513909423986	14	14	0.00222222222222222	6300	7161	9435,6487,10678,10164,93010,8702,8703,6483,6482,4166,8534,2530,8704,2683	CHST2,ST3GAL3,B3GNT2,CHST4,B3GNT7,B4GALT4,B4GALT3,ST3GAL2,ST3GAL1,CHST6,CHST1,FUT8,B4GALT2,B4GALT1
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	0.166104346582106	-1.79513909423986	14	14	0.00222222222222222	6300	7161	8703,8702,6482,6483,2683,8704,8534,4166,2530,10678,9435,6487,93010,10164	B4GALT3,B4GALT4,ST3GAL1,ST3GAL2,B4GALT1,B4GALT2,CHST1,CHST6,FUT8,B3GNT2,CHST2,ST3GAL3,B3GNT7,CHST4
ko05162	Measles	0.174455691357598	-1.74608448730372	133	121	0.0192063492063492	6300	7161	3717,9134,3310,898,6504,1027,6774,3442,3443,916,2932,25898,3306,23586,5291,27113,3449,868,7161,595,940,5970,3596,3456,27102,8503,9641,7297,3460,3560,5296,4179,3312,5295,7099,8797,3304,103,3440,3448,4940,3455,3569,7128,6776,57506,7097,6869,7157,2213,3305,6885,5588,356,8793,1796,3718,23118,3454,7189,4599,1457,5293,3716,10379,3592,3452,3593,1021,5610,4790,355,10399,207,8794,1459,3552,3553,894,4615,917,3665,10332,3441,1965,1017,8795,1019,4939,30835,3439,3559,9451,29110,3459,3565,8667,5290,3445,2534,3661,3458,4792,4793,4938,3558,51135,896,6777,64135,8743,3444,10000,1147,6773,915,6772,208,54106,440275,283106	JAK2,CCNE2,HSPA6,CCNE1,SLAMF1,CDKN1B,STAT3,IFNA5,IFNA6,CD3E,GSK3B,RCHY1,HSPA2,RIGI,PIK3CB,BBC3,IFNA16,CBLB,TP73,CCND1,CD28,RELA,IL13,IFNB1,EIF2AK1,PIK3R3,IKBKE,TYK2,IFNGR2,IL2RB,PIK3R2,CD46,HSPA8,PIK3R1,TLR4,TNFRSF10A,HSPA1B,ADAR,IFNA2,IFNA14,OAS3,IFNAR2,IL6,TNFAIP3,STAT5A,MAVS,TLR2,TACR1,TP53,FCGR2B,HSPA1L,MAP3K7,PRKCQ,FASLG,TNFRSF10D,DOK1,JAK3,TAB2,IFNAR1,TRAF6,MX1,CSNK2A1,PIK3CD,JAK1,IRF9,IL12A,IFNA21,IL12B,CDK6,EIF2AK2,NFKB1,FAS,RACK1,AKT1,TNFRSF10C,CSNK2A2,IL1A,IL1B,CCND2,MYD88,CD3G,IRF7,CLEC4M,IFNA4,EIF2S1,CDK2,TNFRSF10B,CDK4,OAS2,CD209,IFNA1,IL2RA,EIF2AK3,TBK1,IFNGR1,IL4,EIF3H,PIK3CA,IFNA8,FYN,IRF3,IFNG,NFKBIA,NFKBIB,OAS1,IL2,IRAK4,CCND3,STAT5B,IFIH1,TNFSF10,IFNA7,AKT3,CHUK,STAT2,CD3D,STAT1,AKT2,TLR9,EIF2AK4,CSNK2A3
hsa05162	Measles	0.174455691357598	-1.74608448730372	133	121	0.0192063492063492	6300	7161	3661,2534,3445,5290,8667,896,6777,3558,51135,4938,4792,4793,3458,208,6773,915,6772,1147,3444,8743,64135,10000,283106,440275,54106,3716,10379,5293,4599,1457,1459,3552,8794,3553,207,355,10399,1021,5610,4790,3592,3593,3452,3441,1017,1965,3665,10332,917,894,4615,3565,3459,9451,29110,3439,3559,4939,30835,1019,8795,4940,3448,3440,103,3304,8797,5295,7099,3312,7157,7097,6869,57506,6776,7128,3569,3455,5588,6885,3305,2213,7189,3454,23118,3718,1796,8793,356,916,3442,3443,6774,1027,898,6504,9134,3310,3717,23586,25898,3306,2932,3596,3456,27102,5970,940,595,7161,868,3449,5291,27113,4179,3560,5296,3460,7297,8503,9641	IRF3,FYN,IFNA8,PIK3CA,EIF3H,CCND3,STAT5B,IL2,IRAK4,OAS1,NFKBIA,NFKBIB,IFNG,AKT2,STAT2,CD3D,STAT1,CHUK,IFNA7,TNFSF10,IFIH1,AKT3,CSNK2A3,EIF2AK4,TLR9,JAK1,IRF9,PIK3CD,MX1,CSNK2A1,CSNK2A2,IL1A,TNFRSF10C,IL1B,AKT1,FAS,RACK1,CDK6,EIF2AK2,NFKB1,IL12A,IL12B,IFNA21,IFNA4,CDK2,EIF2S1,IRF7,CLEC4M,CD3G,CCND2,MYD88,IL4,IFNGR1,EIF2AK3,TBK1,IFNA1,IL2RA,OAS2,CD209,CDK4,TNFRSF10B,OAS3,IFNA14,IFNA2,ADAR,HSPA1B,TNFRSF10A,PIK3R1,TLR4,HSPA8,TP53,TLR2,TACR1,MAVS,STAT5A,TNFAIP3,IL6,IFNAR2,PRKCQ,MAP3K7,HSPA1L,FCGR2B,TRAF6,IFNAR1,TAB2,JAK3,DOK1,TNFRSF10D,FASLG,CD3E,IFNA5,IFNA6,STAT3,CDKN1B,CCNE1,SLAMF1,CCNE2,HSPA6,JAK2,RIGI,RCHY1,HSPA2,GSK3B,IL13,IFNB1,EIF2AK1,RELA,CD28,CCND1,TP73,CBLB,IFNA16,PIK3CB,BBC3,CD46,IL2RB,PIK3R2,IFNGR2,TYK2,PIK3R3,IKBKE
hsa05202	Transcriptional misregulation in cancer	0.175322853969835	-1.74112612493161	179	162	0.0257142857142857	6300	7161	5218,5914,6667,6495,4299,30012,598,3486,8861,1050,4066,8352,8353,8464,4297,1436,1027,221037,6760,3207,5154,6258,8357,7468,9915,3560,4318,4804,7704,5546,3066,4233,64332,5970,1848,2119,958,860,2005,8148,5328,6935,25942,1991,8013,8091,7157,3684,466,3002,440093,2322,2308,4193,3020,5327,3569,4211,4208,51804,1053,3065,51513,8358,8350,8864,2118,3695,8900,9611,51384,5081,8938,51274,5966,3562,904,79058,54738,4298,3576,7849,862,942,597,4613,3087,2530,2130,5077,2138,7850,4314,4790,8968,4291,7185,1236,1437,126961,1026,3206,5079,929,604,6929,7113,5468,7048,6688,4094,3021,472,330,3195,4609,2209,55589,4914,4353,5090,84444,64083,4005,894,3248,4300,100532731,3728,3398,7490,8842,2078,8290,4086,171558,26471,861,8355,6692,2115,5747,6256,2321,3479,2521,3205,2313,7709,5371,5087,3480,2120,4149,653604,1051,4221,8354,1031,905,648,85414	CDK14,RARA,SP1,SIX1,AFF1,TLX3,BCL2L1,IGFBP3,LDB1,CEBPA,LYL1,H3C3,H3C6,SUPT3H,KMT2A,CSF1R,CDKN1B,JMJD1C,SS18,HOXA11,PDGFA,RXRG,H3C10,NSD2,ARNT2,IL2RB,MMP9,NGFR,ZBTB16,PRCC,HDAC2,MET,NFKBIZ,RELA,DUSP6,ETV5,CD40,RUNX2,ELK4,TAF15,PLAU,ZEB1,SIN3A,ELANE,NR4A3,HMGA2,TP53,ITGAM,ATF1,GZMB,H3-5,FLT3,FOXO1,MDM2,H3-3A,PLAT,IL6,MEIS1,MEF2C,SIX4,CEBPE,HDAC1,ETV7,H3C2,H3C1,PER2,ETV4,ITGB7,CCNA1,NCOR1,WNT16,PAX7,BAIAP3,KLF3,REL,IL3,CCNT1,ASPSCR1,FEV,MLLT1,CXCL8,PAX8,RUNX1T1,CD86,BCL2A1,MYCN,HHEX,FUT8,EWSR1,PAX3,EYA1,IL1R2,MMP3,NFKB1,H3C7,MLF1,TRAF1,CCR7,CSF2,H3C14,CDKN1A,HOXA10,PAX5,CD14,BCL6,TCF3,TMPRSS2,PPARG,TGFBR2,SPI1,MAF,H3-3B,ATM,BIRC3,TLX1,MYC,FCGR1A,BMP2K,NTRK1,MPO,PBX3,DOT1L,GOLPH3,LMO2,CCND2,HPGD,MLLT3,COMMD3-BMI1,JUP,ID2,WT1,PROM1,ERG,H3-4,SMAD1,PTCRA,NUPR1,RUNX1,H3C8,SPINT1,ETV1,PTK2,RXRA,FLT1,IGF1,FUS,HOXA9,FLI1,ZBTB17,PML,PBX1,IGF1R,ETV6,MAX,H3C13,CEBPB,MEN1,H3C11,CDKN2C,CCNT2,BMI1,SLC45A3
ko05202	Transcriptional misregulation in cancer	0.175322853969835	-1.74112612493161	179	162	0.0257142857142857	6300	7161	4066,8353,8352,1050,8861,221037,6258,3207,6760,5154,4297,1436,8464,1027,5914,6667,6495,4299,5218,3486,30012,598,2005,860,958,1848,5970,2119,8013,1991,5328,8148,25942,6935,4318,9915,3560,8357,7468,3066,4233,64332,7704,4804,5546,8358,8350,51513,51804,1053,4208,4211,3065,8900,3695,8864,2118,3002,466,2322,440093,8091,7157,3684,5327,3569,2308,4193,3020,7849,3576,4613,2530,3087,862,597,942,3562,5966,51274,904,51384,9611,8938,5081,54738,4298,79058,3206,126961,1437,1026,929,5079,7850,2130,2138,5077,1236,4790,8968,4314,7185,4291,5090,330,472,4914,55589,4353,2209,4609,3195,4005,894,84444,64083,5468,7048,6929,604,7113,4094,3021,6688,8355,861,171558,26471,5747,6692,2115,3398,3248,3728,4300,100532731,4086,8842,7490,8290,2078,4149,653604,1051,3480,5087,2120,905,648,85414,4221,1031,8354,2321,6256,7709,5371,2313,2521,3205,3479	LYL1,H3C6,H3C3,CEBPA,LDB1,JMJD1C,RXRG,HOXA11,SS18,PDGFA,KMT2A,CSF1R,SUPT3H,CDKN1B,RARA,SP1,SIX1,AFF1,CDK14,IGFBP3,TLX3,BCL2L1,ELK4,RUNX2,CD40,DUSP6,RELA,ETV5,NR4A3,ELANE,PLAU,TAF15,SIN3A,ZEB1,MMP9,ARNT2,IL2RB,H3C10,NSD2,HDAC2,MET,NFKBIZ,ZBTB16,NGFR,PRCC,H3C2,H3C1,ETV7,SIX4,CEBPE,MEF2C,MEIS1,HDAC1,CCNA1,ITGB7,PER2,ETV4,GZMB,ATF1,FLT3,H3-5,HMGA2,TP53,ITGAM,PLAT,IL6,FOXO1,MDM2,H3-3A,PAX8,CXCL8,MYCN,FUT8,HHEX,RUNX1T1,BCL2A1,CD86,IL3,REL,KLF3,CCNT1,WNT16,NCOR1,BAIAP3,PAX7,FEV,MLLT1,ASPSCR1,HOXA10,H3C14,CSF2,CDKN1A,CD14,PAX5,IL1R2,EWSR1,EYA1,PAX3,CCR7,NFKB1,H3C7,MMP3,TRAF1,MLF1,PBX3,BIRC3,ATM,NTRK1,BMP2K,MPO,FCGR1A,MYC,TLX1,LMO2,CCND2,DOT1L,GOLPH3,PPARG,TGFBR2,TCF3,BCL6,TMPRSS2,MAF,H3-3B,SPI1,H3C8,RUNX1,PTCRA,NUPR1,PTK2,SPINT1,ETV1,ID2,HPGD,JUP,MLLT3,COMMD3-BMI1,SMAD1,PROM1,WT1,H3-4,ERG,MAX,H3C13,CEBPB,IGF1R,PBX1,ETV6,CCNT2,BMI1,SLC45A3,MEN1,CDKN2C,H3C11,FLT1,RXRA,ZBTB17,PML,FLI1,FUS,HOXA9,IGF1
hsa00983	Drug metabolism - other enzymes	0.17951762441545	-1.71748188971526	46	43	0.00682539682539683	6300	7161	51733,7172,9,54963,7084,3614,151531,7365,3704,79799,54578,7378,7364,10,574537,1066,3615,54658,83549,1548,54600,1807,10941,54490,7371,7363,1806,8833,7366,54659,54657,1576,54575,2990,54576,7372,7498,978,54579,54577,10720,8824,7083	UPB1,TPMT,NAT1,UCKL1,TK2,IMPDH1,UPP2,UGT2B10,ITPA,UGT2A3,UGT1A6,UPP1,UGT2B7,NAT2,UGT2A2,CES1,IMPDH2,UGT1A1,UCK1,CYP2A6,UGT1A9,DPYS,UGT2A1,UGT2B28,UCK2,UGT2B4,DPYD,GMPS,UGT2B15,UGT1A3,UGT1A4,CYP3A4,UGT1A10,GUSB,UGT1A8,UMPS,XDH,CDA,UGT1A5,UGT1A7,UGT2B11,CES2,TK1
ko00983	Drug metabolism - other enzymes	0.17951762441545	-1.71748188971526	46	43	0.00682539682539683	6300	7161	54657,7366,54659,8833,54575,54578,1576,574537,1066,54577,10,7364,978,54579,7498,7372,2990,54576,7378,7083,8824,3615,54658,83549,10720,9,7172,51733,1548,54600,54963,151531,54490,3614,7371,1807,7084,10941,79799,3704,7365,1806,7363	UGT1A4,UGT2B15,UGT1A3,GMPS,UGT1A10,UGT1A6,CYP3A4,UGT2A2,CES1,UGT1A7,NAT2,UGT2B7,CDA,UGT1A5,XDH,UMPS,GUSB,UGT1A8,UPP1,TK1,CES2,IMPDH2,UGT1A1,UCK1,UGT2B11,NAT1,TPMT,UPB1,CYP2A6,UGT1A9,UCKL1,UPP2,UGT2B28,IMPDH1,UCK2,DPYS,TK2,UGT2A1,UGT2A3,ITPA,UGT2B10,DPYD,UGT2B4
ko04620	Toll-like receptor signaling pathway	0.182153306104636	-1.70290660524136	104	95	0.0150793650793651	6300	7161	207,3553,6373,4790,5601,3452,3593,3592,5606,5293,929,6416,1432,3439,29110,3441,3665,148022,4615,6300,51135,5595,5604,4792,841,7096,6352,3661,941,10454,3445,5290,3627,3929,7124,54106,5605,5594,208,1147,6772,10000,3444,5609,7100,388372,3443,3442,6348,353376,3551,5879,5296,5599,9641,8503,5603,8772,5602,5970,7098,3456,23643,958,2353,5291,3449,3725,54472,7097,3455,3569,3440,3448,7099,5295,8737,10333,3454,7189,414062,114609,6696,6351,23118,5608,5600,1326,3576,1513,3663,6885,942,7187,6349	AKT1,IL1B,CXCL11,NFKB1,MAPK9,IFNA21,IL12B,IL12A,MAP2K3,PIK3CD,CD14,MAP2K4,MAPK14,IFNA1,TBK1,IFNA4,IRF7,TICAM1,MYD88,MAPK12,IRAK4,MAPK3,MAP2K1,NFKBIA,CASP8,TLR1,CCL5,IRF3,CD80,TAB1,IFNA8,PIK3CA,CXCL10,LBP,TNF,TLR9,MAP2K2,MAPK1,AKT2,CHUK,STAT1,AKT3,IFNA7,MAP2K7,TLR5,CCL4L1,IFNA6,IFNA5,CCL3,TICAM2,IKBKB,RAC1,PIK3R2,MAPK8,IKBKE,PIK3R3,MAPK13,FADD,MAPK10,RELA,TLR3,IFNB1,LY96,CD40,FOS,PIK3CB,IFNA16,JUN,TOLLIP,TLR2,IFNAR2,IL6,IFNA2,IFNA14,TLR4,PIK3R1,RIPK1,TLR6,IFNAR1,TRAF6,CCL3L3,TIRAP,SPP1,CCL4,TAB2,MAP2K6,MAPK11,MAP3K8,CXCL8,CTSK,IRF5,MAP3K7,CD86,TRAF3,CCL3L1
hsa04620	Toll-like receptor signaling pathway	0.182153306104636	-1.70290660524136	104	95	0.0150793650793651	6300	7161	6348,3442,3443,353376,7100,5609,388372,958,23643,3456,7098,5970,3449,5291,2353,5296,5879,3551,5602,5603,8772,8503,9641,5599,3440,3448,10333,8737,5295,7099,7097,54472,3725,3569,3455,3663,6885,1513,3576,6349,7187,942,6696,114609,414062,7189,3454,1326,5608,5600,23118,6351,5606,929,5293,6373,3553,207,3592,3452,3593,5601,4790,3665,3441,6300,4615,148022,1432,6416,29110,3439,3445,10454,941,3661,3627,5290,5604,5595,51135,6352,7096,841,4792,6772,1147,208,3444,10000,7124,3929,5594,5605,54106	CCL3,IFNA5,IFNA6,TICAM2,TLR5,MAP2K7,CCL4L1,CD40,LY96,IFNB1,TLR3,RELA,IFNA16,PIK3CB,FOS,PIK3R2,RAC1,IKBKB,MAPK10,MAPK13,FADD,PIK3R3,IKBKE,MAPK8,IFNA2,IFNA14,TLR6,RIPK1,PIK3R1,TLR4,TLR2,TOLLIP,JUN,IL6,IFNAR2,IRF5,MAP3K7,CTSK,CXCL8,CCL3L1,TRAF3,CD86,SPP1,TIRAP,CCL3L3,TRAF6,IFNAR1,MAP3K8,MAP2K6,MAPK11,TAB2,CCL4,MAP2K3,CD14,PIK3CD,CXCL11,IL1B,AKT1,IL12A,IFNA21,IL12B,MAPK9,NFKB1,IRF7,IFNA4,MAPK12,MYD88,TICAM1,MAPK14,MAP2K4,TBK1,IFNA1,IFNA8,TAB1,CD80,IRF3,CXCL10,PIK3CA,MAP2K1,MAPK3,IRAK4,CCL5,TLR1,CASP8,NFKBIA,STAT1,CHUK,AKT2,IFNA7,AKT3,TNF,LBP,MAPK1,MAP2K2,TLR9
hsa_M00050	Guanine ribonucleotide biosynthesis IMP => GDP,GTP	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	5315,10201,5313,29922,3615,3614,4830,4832,2987,4833,4831,654364,8833	PKM,NME6,PKLR,NME7,IMPDH2,IMPDH1,NME1,NME3,GUK1,NME4,NME2,NME1-NME2,GMPS
M00050	Guanine ribonucleotide biosynthesis IMP => GDP,GTP	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	4830,3614,2987,4833,4832,4831,8833,654364,5315,10201,5313,29922,3615	NME1,IMPDH1,GUK1,NME4,NME3,NME2,GMPS,NME1-NME2,PKM,NME6,PKLR,NME7,IMPDH2
ko03450	Non-homologous end-joining	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	79840,2237,4361,1791,7520,10111,2547,7518,5591,3981,27434,27343,64421	NHEJ1,FEN1,MRE11,DNTT,XRCC5,RAD50,XRCC6,XRCC4,PRKDC,LIG4,POLM,POLL,DCLRE1C
M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	64834,9200,201562,79071,6785,51495,79993,83401,401494,9524,54898,51144,60481	ELOVL1,HACD1,HACD2,ELOVL6,ELOVL4,HACD3,ELOVL7,ELOVL3,HACD4,TECR,ELOVL2,HSD17B12,ELOVL5
hsa_M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	83401,401494,9524,54898,60481,51144,79993,79071,6785,51495,64834,9200,201562	ELOVL3,HACD4,TECR,ELOVL2,ELOVL5,HSD17B12,ELOVL7,ELOVL6,ELOVL4,HACD3,ELOVL1,HACD1,HACD2
hsa03450	Non-homologous end-joining	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	64421,27343,27434,3981,5591,7518,2547,10111,7520,2237,1791,4361,79840	DCLRE1C,POLL,POLM,LIG4,PRKDC,XRCC4,XRCC6,RAD50,XRCC5,FEN1,DNTT,MRE11,NHEJ1
hsa_M00676	PI3K-Akt signaling	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	5291,5293,5290,10000,5295,208,8503,2308,3643,5296,3667,207,2309	PIK3CB,PIK3CD,PIK3CA,AKT3,PIK3R1,AKT2,PIK3R3,FOXO1,INSR,PIK3R2,IRS1,AKT1,FOXO3
M00692	Cell cycle - G1/S transition	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	896,1871,5925,1869,1870,1021,1019,1017,5933,595,898,894,9134	CCND3,E2F3,RB1,E2F1,E2F2,CDK6,CDK4,CDK2,RBL1,CCND1,CCNE1,CCND2,CCNE2
hsa_M00692	Cell cycle - G1/S transition	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	1017,5933,595,898,894,9134,1871,896,5925,1869,1870,1021,1019	CDK2,RBL1,CCND1,CCNE1,CCND2,CCNE2,E2F3,CCND3,RB1,E2F1,E2F2,CDK6,CDK4
M00676	PI3K-Akt signaling	0.188852213990718	-1.66679050635139	13	13	0.00206349206349206	6300	7161	208,5293,5290,10000,5295,5291,3667,207,2309,5296,2308,3643,8503	AKT2,PIK3CD,PIK3CA,AKT3,PIK3R1,PIK3CB,IRS1,AKT1,FOXO3,PIK3R2,FOXO1,INSR,PIK3R3
hsa04080	Neuroactive ligand-receptor interaction	0.189508938793378	-1.66331908515854	276	248	0.0393650793650794	6300	7161	2554,2904,5731,2562,2743,2563,2912,5540,3269,2913,9934,152,624,339403,4544,1081,3350,5028,8484,1142,1143,3972,1815,3973,23566,1269,1131,84539,1136,5724,2567,4889,2917,6915,150,53637,148,2862,1268,2901,55584,3062,5734,2150,2906,83551,7433,5618,7201,10316,4987,886,6752,1134,9038,6753,3274,2895,6865,187,5029,1903,1902,135,153,2899,623,1132,10886,6754,1133,5746,1394,3355,5737,6869,146,5025,136,2488,8001,5733,1146,5732,552,2358,151,9294,2911,2741,2561,4157,2690,10203,2566,2916,1141,7434,10161,1137,2147,7442,6751,2359,10888,4986,553,23620,2557,4161,1241,1901,11255,57105,2570,2914,2587,154,3061,2898,2890,2492,2903,3360,1144,59350,728,8811,4543,4142,5340,165829,7068,116444,2831,2891,1511,2847,1814,9340,3361,53829,4887,5617,200959,2569,4923,4988,5032,2555,2905,116443,147,3001,4160,185,2834,2894,2918,1135,2560,2568,2740,140,9287,319100,2696,706,1909,3352,5023,6870,1140,1816,57053,3357,799,2642,6344,5027,3953,3952,155,9568,4829,2688,122042,134864,2859,5739,5031,2897,2837,8698,2149,1139,6755,4985,4886,2900,2908,2558,2550,2832,719,2893,4159,3363,3362,5644,5024,2151,3354,1128,1395,8973,117,2559,2915,887,2565,1138,7252,56923,7253,1129,2357,4158,59340,1145,56288,2798,1910,134,1813,1812,5646,5026,3356,51289,3351,2692,2693,84634,5745,64106,5729,5021	GABRA1,GRIN2B,PTGER1,GABRB3,GLRB,GABRD,GRM2,NPY4R,HRH1,GRM3,P2RY14,ADRA2C,BDKRB2,RXFP4,MTNR1B,CGA,HTR1A,P2RY1,GALR3,CHRNB3,CHRNB4,LHB,DRD4,LHCGR,LPAR3,CNR2,CHRM3,MCHR2,CHRNA3,PTAFR,GABRG3,NPY5R,GRM7,TBXA2R,ADRA2A,S1PR5,ADRA1A,MLNR,CNR1,GRIK5,CHRNA9,HCRTR2,PTGER4,F2RL1,GRIN2D,TAAR8,VIPR1,PRLR,TRHR,NMUR1,OPRL1,CCKAR,SSTR2,CHRNA1,TAAR5,SSTR3,HRH2,GRID2,TACR2,APLNR,P2RY2,S1PR3,LPAR1,ADORA2A,ADRB1,GRIK3,BDKRB1,CHRM4,NPFFR2,SSTR4,CHRM5,PTH2R,CRHR1,HTR1F,PTGFR,TACR1,ADRA1D,P2RX4,ADORA2B,FSHB,GLRA3,PTGER3,CHRNG,PTGER2,AVPR1A,FPR2,ADRA2B,S1PR2,GRM1,GLRA1,GABRB2,MC1R,GHR,CALCRL,GABRG2,GRM6,CHRNB2,VIPR2,LPAR6,CHRNA4,F2,TRPV1,SSTR1,FPR3,GPR83,OPRK1,AVPR1B,NTSR2,GABRA4,MC5R,LTB4R,S1PR1,HRH3,CYSLTR2,GABRR2,GRM4,GALR1,ADRB2,HCRTR1,GRIK2,GRIA1,FSHR,GRIN2A,HTR4,CHRND,RXFP1,C5AR1,GALR2,MTNR1A,MAS1,PLG,GPR156,THRB,GRIN3B,NPBWR1,GRIA2,CTSG,MCHR1,DRD3,GLP2R,HTR5A,P2RY13,NPY2R,PRL,GABRR3,GABRR1,NTSR1,OPRM1,P2RY11,GABRA2,GRIN2C,GRIN3A,ADRA1B,GZMA,MC4R,AGTR1,PRLHR,GRID1,GRM8,CHRNA2,GABRB1,GABRP,GLP1R,ADORA3,TAAR2,TAAR6,GIPR,TSPO,EDNRA,HTR1D,P2RX1,TACR3,CHRNB1,DRD5,CHRNA10,HTR2B,CALCR,GCGR,SCTR,P2RX7,LEPR,LEP,ADRB3,GABBR2,NMBR,GH1,RXFP2,TAAR1,GPR35,PTGIR,P2RY6,GRIK1,UTS2R,S1PR4,F2R,CHRNA7,SSTR5,OPRD1,NPY1R,GRIK4,NR3C1,GABRA5,GABBR1,NPBWR2,C3AR1,GRIA4,MC3R,HTR7,HTR6,PRSS1,P2RX3,F2RL2,HTR1E,CHRM1,CRHR2,CHRNA6,ADCYAP1R1,GABRA6,GRM5,CCKBR,GABRG1,CHRNA5,TSHB,NMUR2,TSHR,CHRM2,FPR1,MC2R,HRH4,CHRNE,PARD3,GNRHR,EDNRB,ADORA1,DRD2,DRD1,PRSS3,P2RX5,HTR2A,RXFP3,HTR1B,GHRHR,GHSR,KISS1R,PTH1R,NPFFR1,PTGDR,OXTR
ko04080	Neuroactive ligand-receptor interaction	0.189508938793378	-1.66331908515854	276	248	0.0393650793650794	6300	7161	3001,4160,185,147,2555,2905,116443,4923,4988,5032,5617,4887,200959,2569,53829,3361,1814,2847,9340,116444,2831,2891,1511,7068,165829,4142,5340,4829,9568,155,5027,3953,3952,2642,6344,3357,799,1816,1140,57053,5023,6870,3352,1909,9287,140,706,2696,319100,2918,1135,2560,2740,2568,2834,2894,1395,8973,3354,1128,5644,5024,2151,4159,3363,3362,2550,2900,2558,2908,2893,719,2832,4985,4886,6755,2149,1139,8698,2897,2837,5031,134864,2859,5739,122042,2688,5021,64106,5729,84634,5745,2692,3351,2693,51289,3356,5646,5026,1813,134,1812,1145,2798,56288,1910,59340,4158,1129,2357,7252,56923,7253,2915,887,2565,1138,2559,117,5724,2567,6915,4889,2917,1136,84539,1269,1131,3972,1815,23566,3973,8484,1142,1143,5028,1081,3350,339403,624,4544,9934,152,2562,2743,2563,2912,5540,2913,3269,5731,2904,2554,153,1903,135,1902,6865,187,5029,2895,6752,1134,9038,6753,3274,886,10316,4987,7201,83551,7433,5618,2150,2906,55584,3062,5734,2901,2862,1268,150,53637,148,1137,2147,7434,1141,10161,2566,2916,2690,10203,2911,2561,2741,4157,552,2358,9294,151,8001,1146,5733,5732,136,2488,6869,146,5025,3355,5737,1394,10886,6754,1132,1133,5746,2899,623,8811,4543,728,59350,3360,1144,2898,2890,2903,2492,154,3061,2914,2587,2570,1241,1901,11255,57105,23620,2557,4161,4986,553,10888,2359,7442,6751	GZMA,MC4R,AGTR1,ADRA1B,GABRA2,GRIN2C,GRIN3A,NTSR1,OPRM1,P2RY11,PRL,NPY2R,GABRR3,GABRR1,P2RY13,HTR5A,DRD3,MCHR1,GLP2R,GRIN3B,NPBWR1,GRIA2,CTSG,THRB,GPR156,MAS1,PLG,NMBR,GABBR2,ADRB3,P2RX7,LEPR,LEP,GCGR,SCTR,HTR2B,CALCR,DRD5,CHRNB1,CHRNA10,P2RX1,TACR3,HTR1D,EDNRA,TAAR2,ADORA3,TSPO,GIPR,TAAR6,GRM8,CHRNA2,GABRB1,GLP1R,GABRP,PRLHR,GRID1,CRHR2,CHRNA6,HTR1E,CHRM1,PRSS1,P2RX3,F2RL2,MC3R,HTR7,HTR6,GABBR1,GRIK4,GABRA5,NR3C1,GRIA4,C3AR1,NPBWR2,OPRD1,NPY1R,SSTR5,F2R,CHRNA7,S1PR4,GRIK1,UTS2R,P2RY6,TAAR1,GPR35,PTGIR,RXFP2,GH1,OXTR,NPFFR1,PTGDR,KISS1R,PTH1R,GHRHR,HTR1B,GHSR,RXFP3,HTR2A,PRSS3,P2RX5,DRD2,ADORA1,DRD1,CHRNE,GNRHR,PARD3,EDNRB,HRH4,MC2R,CHRM2,FPR1,TSHB,NMUR2,TSHR,GRM5,CCKBR,GABRG1,CHRNA5,GABRA6,ADCYAP1R1,PTAFR,GABRG3,TBXA2R,NPY5R,GRM7,CHRNA3,MCHR2,CNR2,CHRM3,LHB,DRD4,LPAR3,LHCGR,GALR3,CHRNB3,CHRNB4,P2RY1,CGA,HTR1A,RXFP4,BDKRB2,MTNR1B,P2RY14,ADRA2C,GABRB3,GLRB,GABRD,GRM2,NPY4R,GRM3,HRH1,PTGER1,GRIN2B,GABRA1,ADRB1,S1PR3,ADORA2A,LPAR1,TACR2,APLNR,P2RY2,GRID2,SSTR2,CHRNA1,TAAR5,SSTR3,HRH2,CCKAR,NMUR1,OPRL1,TRHR,TAAR8,VIPR1,PRLR,F2RL1,GRIN2D,CHRNA9,HCRTR2,PTGER4,GRIK5,MLNR,CNR1,ADRA2A,S1PR5,ADRA1A,CHRNA4,F2,VIPR2,CHRNB2,LPAR6,GABRG2,GRM6,GHR,CALCRL,GRM1,GABRB2,GLRA1,MC1R,AVPR1A,FPR2,S1PR2,ADRA2B,GLRA3,CHRNG,PTGER3,PTGER2,ADORA2B,FSHB,TACR1,ADRA1D,P2RX4,HTR1F,PTGFR,CRHR1,NPFFR2,SSTR4,CHRM4,CHRM5,PTH2R,GRIK3,BDKRB1,GALR2,MTNR1A,C5AR1,RXFP1,HTR4,CHRND,GRIK2,GRIA1,GRIN2A,FSHR,ADRB2,HCRTR1,GRM4,GALR1,GABRR2,LTB4R,S1PR1,HRH3,CYSLTR2,NTSR2,GABRA4,MC5R,OPRK1,AVPR1B,GPR83,FPR3,TRPV1,SSTR1
hsa05230	Central carbon metabolism in cancer	0.19002267469895	-1.66061187342137	65	60	0.00952380952380952	6300	7161	4916,57103,5211,5223,3101,2261,3417,5605,5594,208,2645,10000,4893,6514,7157,27165,5595,5604,2322,2263,5728,2064,5156,3099,6510,5290,5159,5979,5295,3815,23410,3091,5894,5296,1956,8503,5214,4233,4914,2475,5161,4609,3098,8140,2744,3265,51548,5291,207,9123,5224,80201,2260,6513,5315,5162,5163,3845,3939,5293	NTRK3,TIGAR,PFKL,PGAM1,HK3,FGFR3,IDH1,MAP2K2,MAPK1,AKT2,GCK,AKT3,NRAS,SLC2A2,TP53,GLS2,MAPK3,MAP2K1,FLT3,FGFR2,PTEN,ERBB2,PDGFRA,HK2,SLC1A5,PIK3CA,PDGFRB,RET,PIK3R1,KIT,SIRT3,HIF1A,RAF1,PIK3R2,EGFR,PIK3R3,PFKP,MET,NTRK1,MTOR,PDHA2,MYC,HK1,SLC7A5,GLS,HRAS,SIRT6,PIK3CB,AKT1,SLC16A3,PGAM2,HKDC1,FGFR1,SLC2A1,PKM,PDHB,PDK1,KRAS,LDHA,PIK3CD
ko05230	Central carbon metabolism in cancer	0.19002267469895	-1.66061187342137	65	60	0.00952380952380952	6300	7161	208,6514,10000,2645,4893,57103,5211,4916,5594,5605,3417,5223,3101,2261,3099,6510,23410,3091,5979,5295,5159,5290,3815,2322,7157,5604,5595,27165,5728,2263,5156,2064,4609,4914,5161,2475,5291,51548,3265,8140,3098,2744,5296,5894,8503,5214,4233,1956,5163,5162,3939,3845,5315,6513,5293,5224,9123,207,2260,80201	AKT2,SLC2A2,AKT3,GCK,NRAS,TIGAR,PFKL,NTRK3,MAPK1,MAP2K2,IDH1,PGAM1,HK3,FGFR3,HK2,SLC1A5,SIRT3,HIF1A,RET,PIK3R1,PDGFRB,PIK3CA,KIT,FLT3,TP53,MAP2K1,MAPK3,GLS2,PTEN,FGFR2,PDGFRA,ERBB2,MYC,NTRK1,PDHA2,MTOR,PIK3CB,SIRT6,HRAS,SLC7A5,HK1,GLS,PIK3R2,RAF1,PIK3R3,PFKP,MET,EGFR,PDK1,PDHB,LDHA,KRAS,PKM,SLC2A1,PIK3CD,PGAM2,SLC16A3,AKT1,FGFR1,HKDC1
ko00250	Alanine, aspartate and glutamate metabolism	0.190139555001885	-1.65999697642485	35	33	0.00523809523809524	6300	7161	2571,57494,2346,158,122622,440,2805,2752,56954,790,27165,259307,2744,435,2572,445,18,2806,443,339983,5471,2746,9945,2673,189,7915,64902,159,1373,8528,84706,8659,284716	GAD1,RIMKLB,FOLH1,ADSL,ADSS1,ASNS,GOT1,GLUL,NIT2,CAD,GLS2,IL4I1,GLS,ASL,GAD2,ASS1,ABAT,GOT2,ASPA,NAT8L,PPAT,GLUD1,GFPT2,GFPT1,AGXT,ALDH5A1,AGXT2,ADSS2,CPS1,DDO,GPT2,ALDH4A1,RIMKLA
hsa00350	Tyrosine metabolism	0.190139555001885	-1.65999697642485	35	33	0.00523809523809524	6300	7161	2184,222,4282,5409,130,316,7054,126,220,2805,7306,128,259307,6898,3242,1644,1638,218,127,1312,7173,7299,125,221,2806,131,2954,314,124,3081,1621,8639,81889	FAH,ALDH3B2,MIF,PNMT,ADH6,AOX1,TH,ADH1C,ALDH1A3,GOT1,TYRP1,ADH5,IL4I1,TAT,HPD,DDC,DCT,ALDH3A1,ADH4,COMT,TPO,TYR,ADH1B,ALDH3B1,GOT2,ADH7,GSTZ1,AOC2,ADH1A,HGD,DBH,AOC3,FAHD1
hsa00250	Alanine, aspartate and glutamate metabolism	0.190139555001885	-1.65999697642485	35	33	0.00523809523809524	6300	7161	27165,790,259307,2752,2805,440,56954,122622,158,2571,57494,2346,159,1373,8528,84706,8659,284716,9945,5471,2746,189,7915,2673,64902,18,443,2806,339983,435,2744,2572,445	GLS2,CAD,IL4I1,GLUL,GOT1,ASNS,NIT2,ADSS1,ADSL,GAD1,RIMKLB,FOLH1,ADSS2,CPS1,DDO,GPT2,ALDH4A1,RIMKLA,GFPT2,PPAT,GLUD1,AGXT,ALDH5A1,GFPT1,AGXT2,ABAT,ASPA,GOT2,NAT8L,ASL,GLS,GAD2,ASS1
ko00350	Tyrosine metabolism	0.190139555001885	-1.65999697642485	35	33	0.00523809523809524	6300	7161	6898,259307,1644,3242,7306,2805,128,130,126,220,7054,316,4282,222,2184,5409,81889,3081,124,1621,314,2954,8639,221,125,7299,131,2806,7173,1312,218,127,1638	TAT,IL4I1,DDC,HPD,TYRP1,GOT1,ADH5,ADH6,ADH1C,ALDH1A3,TH,AOX1,MIF,ALDH3B2,FAH,PNMT,FAHD1,HGD,ADH1A,DBH,AOC2,GSTZ1,AOC3,ALDH3B1,ADH1B,TYR,ADH7,GOT2,TPO,COMT,ALDH3A1,ADH4,DCT
ko05130	Pathogenic Escherichia coli infection	0.19255961433173	-1.64734948835659	55	51	0.00809523809523809	6300	7161	3875,10381,10093,7430,8440,2534,3059,8976,7099,9181,4690,79861,7846,3688,7280,25,81873,7277,7534,60,10382,51807,10552,100506658,9076,7100,998,4691,9475,5578,1499,203068,347733,387,112714,10094,10376,929,7278,347688,2017,10092,10095,84790,71,81027,84617,10971,999,23643,10109	KRT18,TUBB3,ARPC4,EZR,NCK2,FYN,HCLS1,WASL,TLR4,ARHGEF2,NCK1,TUBAL3,TUBA1A,ITGB1,TUBB2A,ABL1,ARPC5L,TUBA4A,YWHAZ,ACTB,TUBB4A,TUBA8,ARPC1A,OCLN,CLDN1,TLR5,CDC42,NCL,ROCK2,PRKCA,CTNNB1,TUBB,TUBB2B,RHOA,TUBA3E,ARPC3,TUBA1B,CD14,TUBA3C,TUBB8,CTTN,ARPC5,ARPC1B,TUBA1C,ACTG1,TUBB1,TUBB6,YWHAQ,CDH1,LY96,ARPC2
ko05221	Acute myeloid leukemia	0.19255961433173	-1.64734948835659	55	51	0.00809523809523809	6300	7161	2322,3728,5604,6777,5595,6776,5467,861,8900,3815,5290,5295,5371,5594,5605,51176,6198,1147,208,83439,4893,10000,862,6932,5914,2885,207,4790,3845,6655,6934,1050,6199,5293,6774,5292,1978,5296,3551,5894,8503,6688,7704,595,2475,4609,5970,673,3265,5291,6654	FLT3,JUP,MAP2K1,STAT5B,MAPK3,STAT5A,PPARD,RUNX1,CCNA1,KIT,PIK3CA,PIK3R1,PML,MAPK1,MAP2K2,LEF1,RPS6KB1,CHUK,AKT2,TCF7L1,NRAS,AKT3,RUNX1T1,TCF7,RARA,GRB2,AKT1,NFKB1,KRAS,SOS2,TCF7L2,CEBPA,RPS6KB2,PIK3CD,STAT3,PIM1,EIF4EBP1,PIK3R2,IKBKB,RAF1,PIK3R3,SPI1,ZBTB16,CCND1,MTOR,MYC,RELA,BRAF,HRAS,PIK3CB,SOS1
hsa05221	Acute myeloid leukemia	0.19255961433173	-1.64734948835659	55	51	0.00809523809523809	6300	7161	5894,3551,5296,6688,7704,8503,5970,2475,4609,595,6654,3265,5291,673,207,2885,5914,4790,1050,6655,6934,3845,1978,6774,5293,5292,6199,51176,5605,5594,5371,208,83439,1147,6198,862,10000,6932,4893,3728,5604,5595,6777,2322,6776,861,5467,5290,5295,3815,8900	RAF1,IKBKB,PIK3R2,SPI1,ZBTB16,PIK3R3,RELA,MTOR,MYC,CCND1,SOS1,HRAS,PIK3CB,BRAF,AKT1,GRB2,RARA,NFKB1,CEBPA,SOS2,TCF7L2,KRAS,EIF4EBP1,STAT3,PIK3CD,PIM1,RPS6KB2,LEF1,MAP2K2,MAPK1,PML,AKT2,TCF7L1,CHUK,RPS6KB1,RUNX1T1,AKT3,TCF7,NRAS,JUP,MAP2K1,MAPK3,STAT5B,FLT3,STAT5A,RUNX1,PPARD,PIK3CA,PIK3R1,KIT,CCNA1
hsa05130	Pathogenic Escherichia coli infection	0.19255961433173	-1.64734948835659	55	51	0.00809523809523809	6300	7161	2534,3059,8976,7099,3875,10381,8440,7430,10093,10382,51807,10552,79861,4690,9181,7846,7280,3688,7534,60,81873,7277,25,112714,10094,10376,929,7278,998,9076,100506658,7100,9475,5578,4691,1499,387,347733,203068,10971,999,23643,10109,2017,347688,10092,81027,71,84790,10095,84617	FYN,HCLS1,WASL,TLR4,KRT18,TUBB3,NCK2,EZR,ARPC4,TUBB4A,TUBA8,ARPC1A,TUBAL3,NCK1,ARHGEF2,TUBA1A,TUBB2A,ITGB1,YWHAZ,ACTB,ARPC5L,TUBA4A,ABL1,TUBA3E,ARPC3,TUBA1B,CD14,TUBA3C,CDC42,CLDN1,OCLN,TLR5,ROCK2,PRKCA,NCL,CTNNB1,RHOA,TUBB2B,TUBB,YWHAQ,CDH1,LY96,ARPC2,CTTN,TUBB8,ARPC5,TUBB1,ACTG1,TUBA1C,ARPC1B,TUBB6
hsa05150	Staphylococcus aureus infection	0.19255961433173	-1.64734948835659	55	51	0.00809523809523809	6300	7161	717,2209,3383,3127,1675,2215,728,3112,3113,720,3683,2214,2359,6404,716,3117,3119,712,3122,3586,3123,3689,3108,2357,3111,3858,10747,719,2266,713,2204,3075,6403,2358,2213,715,2212,5724,3109,714,3118,1828,727,629,5340,718,3684,5648,4153,3426,9103	C2,FCGR1A,ICAM1,HLA-DRB5,CFD,FCGR3B,C5AR1,HLA-DOB,HLA-DPA1,C4A,ITGAL,FCGR3A,FPR3,SELPLG,C1S,HLA-DQA1,HLA-DQB1,C1QA,HLA-DRA,IL10,HLA-DRB1,ITGB2,HLA-DMA,FPR1,HLA-DOA,KRT10,MASP2,C3AR1,FGG,C1QB,FCAR,CFH,SELP,FPR2,FCGR2B,C1R,FCGR2A,PTAFR,HLA-DMB,C1QC,HLA-DQA2,DSG1,C5,CFB,PLG,C3,ITGAM,MASP1,MBL2,CFI,FCGR2C
ko05150	Staphylococcus aureus infection	0.19255961433173	-1.64734948835659	55	51	0.00809523809523809	6300	7161	1675,2215,717,2209,3383,3127,3112,720,3113,3683,728,716,3117,2214,2359,6404,3111,3108,2357,3858,10747,3119,712,3122,3123,3586,3689,3075,6403,2358,2213,715,2212,2266,719,713,2204,3118,5724,3109,714,629,5340,1828,727,3426,9103,718,3684,4153,5648	CFD,FCGR3B,C2,FCGR1A,ICAM1,HLA-DRB5,HLA-DOB,C4A,HLA-DPA1,ITGAL,C5AR1,C1S,HLA-DQA1,FCGR3A,FPR3,SELPLG,HLA-DOA,HLA-DMA,FPR1,KRT10,MASP2,HLA-DQB1,C1QA,HLA-DRA,HLA-DRB1,IL10,ITGB2,CFH,SELP,FPR2,FCGR2B,C1R,FCGR2A,FGG,C3AR1,C1QB,FCAR,HLA-DQA2,PTAFR,HLA-DMB,C1QC,CFB,PLG,DSG1,C5,CFI,FCGR2C,C3,ITGAM,MBL2,MASP1
hsa00270	Cysteine and methionine metabolism	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	4191,586,64902,875,3945,3948,51074,1788,84245,4548,1036,4507,2937,7263,10993,2806,4144,27430,2805,58478,4190,55256,191,635,259307,113675,160287,6723,587,6898,1491,92483,2730,10768,4143,23382,23743,1786,2729,262,3939	MDH2,BCAT1,AGXT2,CBS,LDHB,LDHC,APIP,DNMT3A,MRI1,MTR,CDO1,MTAP,GSS,TST,SDS,GOT2,MAT2A,MAT2B,GOT1,ENOPH1,MDH1,ADI1,AHCY,BHMT,IL4I1,SDSL,LDHAL6A,SRM,BCAT2,TAT,CTH,LDHAL6B,GCLM,AHCYL1,MAT1A,AHCYL2,BHMT2,DNMT1,GCLC,AMD1,LDHA
ko00270	Cysteine and methionine metabolism	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	4548,1036,1788,84245,875,3945,51074,3948,4191,586,64902,2806,4144,7263,10993,2937,4507,1491,92483,2730,10768,635,259307,160287,113675,6723,6898,587,4190,55256,191,27430,58478,2805,262,3939,23743,1786,2729,4143,23382	MTR,CDO1,DNMT3A,MRI1,CBS,LDHB,APIP,LDHC,MDH2,BCAT1,AGXT2,GOT2,MAT2A,TST,SDS,GSS,MTAP,CTH,LDHAL6B,GCLM,AHCYL1,BHMT,IL4I1,LDHAL6A,SDSL,SRM,TAT,BCAT2,MDH1,ADI1,AHCY,MAT2B,ENOPH1,GOT1,AMD1,LDHA,BHMT2,DNMT1,GCLC,MAT1A,AHCYL2
hsa04973	Carbohydrate digestion and absorption	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	5291,6514,3938,2538,6523,10000,3098,93432,6476,208,483,478,8503,3101,476,481,5579,2542,5296,83756,8972,276,776,5290,486,5295,5293,346562,3099,6518,92579,480,279,57818,80201,5330,80834,280,207,482,477	PIK3CB,SLC2A2,LCT,G6PC1,SLC5A1,AKT3,HK1,MGAM2,SI,AKT2,ATP1B3,ATP1A3,PIK3R3,HK3,ATP1A1,ATP1B1,PRKCB,SLC37A4,PIK3R2,TAS1R3,MGAM,AMY1A,CACNA1D,PIK3CA,FXYD2,PIK3R1,PIK3CD,GNAT3,HK2,SLC2A5,G6PC3,ATP1A4,AMY2A,G6PC2,HKDC1,PLCB2,TAS1R2,AMY2B,AKT1,ATP1B2,ATP1A2
ko00071	Fatty acid degradation	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	1374,219,36,217,128,2639,8310,1579,1376,35,10449,81616,38,34,130,2181,33,23305,126129,126,30,223,10455,124,51,39,37,501,284541,23205,51703,3033,3032,127,1632,3030,224,125,131,1962,2180	CPT1A,ALDH1B1,ACADSB,ALDH2,ADH5,GCDH,ACOX3,CYP4A11,CPT2,ACADS,ACAA2,ACSBG2,ACAT1,ACADM,ADH6,ACSL3,ACADL,ACSL6,CPT1C,ADH1C,ACAA1,ALDH9A1,ECI2,ADH1A,ACOX1,ACAT2,ACADVL,ALDH7A1,CYP4A22,ACSBG1,ACSL5,HADH,HADHB,ADH4,ECI1,HADHA,ALDH3A2,ADH1B,ADH7,EHHADH,ACSL1
hsa00071	Fatty acid degradation	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	39,51,10455,124,30,223,23205,284541,37,501,1632,3030,224,3033,3032,127,51703,2180,1962,131,125,219,36,128,217,1374,8310,1579,2639,81616,10449,35,1376,126,23305,33,126129,2181,38,130,34	ACAT2,ACOX1,ECI2,ADH1A,ACAA1,ALDH9A1,ACSBG1,CYP4A22,ACADVL,ALDH7A1,ECI1,HADHA,ALDH3A2,HADH,HADHB,ADH4,ACSL5,ACSL1,EHHADH,ADH7,ADH1B,ALDH1B1,ACADSB,ADH5,ALDH2,CPT1A,ACOX3,CYP4A11,GCDH,ACSBG2,ACAA2,ACADS,CPT2,ADH1C,ACSL6,ACADL,CPT1C,ACSL3,ACAT1,ADH6,ACADM
ko04962	Vasopressin-regulated water reabsorption	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	51143,5878,361,84516,5869,8655,2778,1781,9586,359,51164,6810,5567,396,148327,10671,1639,115,1385,90993,551,5566,1778,109,10488,360,5568,51626,112,84699,79659,64764,1780,1783,10540,5868,8766,4905,6844,140735,397	DYNC1LI1,RAB5C,AQP4,DCTN5,RAB5B,DYNLL1,GNAS,DYNC1I2,CREB5,AQP2,DCTN4,STX4,PRKACB,ARHGDIA,CREB3L4,DCTN6,DCTN1,ADCY9,CREB1,CREB3L1,AVP,PRKACA,DYNC1H1,ADCY3,CREB3,AQP3,PRKACG,DYNC2LI1,ADCY6,CREB3L3,DYNC2H1,CREB3L2,DYNC1I1,DYNC1LI2,DCTN2,RAB5A,RAB11A,NSF,VAMP2,DYNLL2,ARHGDIB
hsa04962	Vasopressin-regulated water reabsorption	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	8766,4905,140735,6844,397,10488,5568,360,51626,112,84699,79659,64764,1780,1783,10540,5868,6810,396,5567,148327,10671,1639,115,90993,551,1385,5566,1778,109,51143,5878,361,8655,5869,84516,2778,1781,9586,359,51164	RAB11A,NSF,DYNLL2,VAMP2,ARHGDIB,CREB3,PRKACG,AQP3,DYNC2LI1,ADCY6,CREB3L3,DYNC2H1,CREB3L2,DYNC1I1,DYNC1LI2,DCTN2,RAB5A,STX4,ARHGDIA,PRKACB,CREB3L4,DCTN6,DCTN1,ADCY9,CREB3L1,AVP,CREB1,PRKACA,DYNC1H1,ADCY3,DYNC1LI1,RAB5C,AQP4,DYNLL1,RAB5B,DCTN5,GNAS,DYNC1I2,CREB5,AQP2,DCTN4
ko04973	Carbohydrate digestion and absorption	0.207701606837998	-1.57165281178913	44	41	0.00650793650793651	6300	7161	92579,6518,3099,346562,5293,5295,486,5290,776,477,482,207,280,5330,80834,80201,279,57818,480,483,478,208,6476,93432,3098,6523,10000,2538,3938,5291,6514,276,8972,83756,5296,2542,5579,481,476,3101,8503	G6PC3,SLC2A5,HK2,GNAT3,PIK3CD,PIK3R1,FXYD2,PIK3CA,CACNA1D,ATP1A2,ATP1B2,AKT1,AMY2B,PLCB2,TAS1R2,HKDC1,AMY2A,G6PC2,ATP1A4,ATP1B3,ATP1A3,AKT2,SI,MGAM2,HK1,SLC5A1,AKT3,G6PC1,LCT,PIK3CB,SLC2A2,AMY1A,MGAM,TAS1R3,PIK3R2,SLC37A4,PRKCB,ATP1B1,ATP1A1,HK3,PIK3R3
hsa04658	Th1 and Th2 cell differentiation	0.207807869117398	-1.57114133232661	92	84	0.0133333333333333	6300	7161	920,3565,4794,3560,1432,3459,3551,3460,3113,5599,3112,7297,3559,4094,5603,5602,3596,5970,3127,6775,6778,84441,917,2353,6300,3932,3123,3122,5532,3119,5533,4772,4773,4790,5601,3593,3592,3108,3111,916,3716,4854,182,3117,9794,3717,864,2625,3594,3109,3718,3118,3516,5600,5534,5594,5588,6772,4853,915,1147,10683,919,30009,5535,54567,6777,5595,3725,5530,3558,7535,3714,27040,4793,6776,5335,4792,4775,3595,3458,55534,3567,3566	CD4,IL4,NFKBIE,IL2RB,MAPK14,IFNGR1,IKBKB,IFNGR2,HLA-DPA1,MAPK8,HLA-DOB,TYK2,IL2RA,MAF,MAPK13,MAPK10,IL13,RELA,HLA-DRB5,STAT4,STAT6,MAML2,CD3G,FOS,MAPK12,LCK,HLA-DRB1,HLA-DRA,PPP3CB,HLA-DQB1,PPP3CC,NFATC1,NFATC2,NFKB1,MAPK9,IL12B,IL12A,HLA-DMA,HLA-DOA,CD3E,JAK1,NOTCH3,JAG1,HLA-DQA1,MAML1,JAK2,RUNX3,GATA3,IL12RB1,HLA-DMB,JAK3,HLA-DQA2,RBPJ,MAPK11,PPP3R1,MAPK1,PRKCQ,STAT1,NOTCH2,CD3D,CHUK,DLL3,CD247,TBX21,PPP3R2,DLL4,STAT5B,MAPK3,JUN,PPP3CA,IL2,ZAP70,JAG2,LAT,NFKBIB,STAT5A,PLCG1,NFKBIA,NFATC3,IL12RB2,IFNG,MAML3,IL5,IL4R
ko04658	Th1 and Th2 cell differentiation	0.207807869117398	-1.57114133232661	92	84	0.0133333333333333	6300	7161	5335,4793,27040,6776,4792,4775,3595,3458,5535,54567,5595,6777,5530,3725,3558,7535,3714,3566,55534,3567,3718,3118,3516,5600,5534,5594,3594,3109,919,30009,5588,6772,4853,915,1147,10683,4772,4773,4790,5601,3593,3592,3108,3111,3123,3122,5532,5533,3119,4854,3117,182,9794,3717,2625,864,916,3716,3113,3460,5599,3112,7297,3559,4094,5603,5602,920,3565,4794,3560,3459,1432,3551,84441,917,2353,6300,3932,3596,5970,3127,6775,6778	PLCG1,NFKBIB,LAT,STAT5A,NFKBIA,NFATC3,IL12RB2,IFNG,PPP3R2,DLL4,MAPK3,STAT5B,PPP3CA,JUN,IL2,ZAP70,JAG2,IL4R,MAML3,IL5,JAK3,HLA-DQA2,RBPJ,MAPK11,PPP3R1,MAPK1,IL12RB1,HLA-DMB,CD247,TBX21,PRKCQ,STAT1,NOTCH2,CD3D,CHUK,DLL3,NFATC1,NFATC2,NFKB1,MAPK9,IL12B,IL12A,HLA-DMA,HLA-DOA,HLA-DRB1,HLA-DRA,PPP3CB,PPP3CC,HLA-DQB1,NOTCH3,HLA-DQA1,JAG1,MAML1,JAK2,GATA3,RUNX3,CD3E,JAK1,HLA-DPA1,IFNGR2,MAPK8,HLA-DOB,TYK2,IL2RA,MAF,MAPK13,MAPK10,CD4,IL4,NFKBIE,IL2RB,IFNGR1,MAPK14,IKBKB,MAML2,CD3G,FOS,MAPK12,LCK,IL13,RELA,HLA-DRB5,STAT4,STAT6
ko01524	Platinum drug resistance	0.209151761167727	-1.56469516053303	73	67	0.0106349206349206	6300	7161	4259,598,355,7507,2953,2952,207,4436,1029,5293,581,329,1026,2067,4257,9446,8772,8503,4292,2947,5296,2939,2946,540,221357,317,2941,2956,27113,5291,2949,330,119391,472,7155,4193,1244,2064,1317,841,672,2938,4217,5595,7157,5980,2950,578,2940,2948,5290,54205,5295,5366,596,5429,356,5594,4258,842,836,10000,332,5170,208,7153,2944	MGST3,BCL2L1,FAS,XPA,GSTT2,GSTT1,AKT1,MSH2,CDKN2A,PIK3CD,BAX,BIRC2,CDKN1A,ERCC1,MGST1,GSTO1,FADD,PIK3R3,MLH1,GSTM3,PIK3R2,GSTA2,GSTM2,ATP7B,GSTA5,APAF1,GSTA4,MSH6,BBC3,PIK3CB,GSTM5,BIRC3,GSTO2,ATM,TOP2B,MDM2,ABCC2,ERBB2,SLC31A1,CASP8,BRCA1,GSTA1,MAP3K5,MAPK3,TP53,REV3L,GSTP1,BAK1,GSTA3,GSTM4,PIK3CA,CYCS,PIK3R1,PMAIP1,BCL2,POLH,FASLG,MAPK1,MGST2,CASP9,CASP3,AKT3,BIRC5,PDPK1,AKT2,TOP2A,GSTM1
hsa01524	Platinum drug resistance	0.209151761167727	-1.56469516053303	73	67	0.0106349206349206	6300	7161	5429,596,5366,2940,2948,5290,5295,54205,578,4217,5595,5980,2950,7157,2064,1317,841,2938,672,4193,1244,7153,2944,208,332,5170,836,10000,842,4258,356,5594,2067,4257,1026,581,329,5293,4436,1029,2953,2952,207,7507,598,4259,355,7155,2949,330,119391,472,2941,2956,27113,5291,221357,540,317,5296,2946,2939,8772,4292,8503,2947,9446	POLH,BCL2,PMAIP1,GSTA3,GSTM4,PIK3CA,PIK3R1,CYCS,BAK1,MAP3K5,MAPK3,REV3L,GSTP1,TP53,ERBB2,SLC31A1,CASP8,GSTA1,BRCA1,MDM2,ABCC2,TOP2A,GSTM1,AKT2,BIRC5,PDPK1,CASP3,AKT3,CASP9,MGST2,FASLG,MAPK1,ERCC1,MGST1,CDKN1A,BAX,BIRC2,PIK3CD,MSH2,CDKN2A,GSTT2,GSTT1,AKT1,XPA,BCL2L1,MGST3,FAS,TOP2B,GSTM5,BIRC3,GSTO2,ATM,GSTA4,MSH6,BBC3,PIK3CB,GSTA5,ATP7B,APAF1,PIK3R2,GSTM2,GSTA2,FADD,MLH1,PIK3R3,GSTM3,GSTO1
hsa04910	Insulin signaling pathway	0.209902410740342	-1.56111256703645	138	125	0.0198412698412698	6300	7161	6655,5509,3991,10891,23265,6199,122809,5105,51763,23624,9470,5564,5507,3643,53632,2932,2872,801,79660,2997,6654,868,3098,3265,5291,3636,5499,5296,6517,31,3551,6009,5599,5140,5565,2194,5602,57521,8503,9021,92579,3099,5566,5295,5590,25759,32,3667,5573,867,2308,2998,9322,6198,8789,5577,2645,5837,2538,5770,5792,5500,2889,3845,5293,2203,5501,1978,8835,5575,5506,51422,2885,207,6720,80201,5601,2475,673,23433,5257,5834,7249,5894,91860,399694,8660,8651,5568,5313,5261,10211,810,5290,6194,163688,808,5567,3630,5584,5604,5595,6464,2319,10580,57818,7248,5836,208,10603,51806,4893,10000,5576,5170,805,1398,5571,5562,5563,53358,3101,1977,5594,5605	SOS2,PPP1R3D,LIPE,PPARGC1A,EXOC7,RPS6KB2,SOCS4,PCK1,INPP5K,CBLC,EIF4E2,PRKAB1,PPP1R3C,INSR,PRKAG3,GSK3B,MKNK2,CALM1,PPP1R3B,GYS1,SOS1,CBLB,HK1,HRAS,PIK3CB,INPPL1,PPP1CA,PIK3R2,SLC2A4,ACACA,IKBKB,RHEB,MAPK8,PDE3B,PRKAB2,FASN,MAPK10,RPTOR,PIK3R3,SOCS3,G6PC3,HK2,PRKACA,PIK3R1,PRKCZ,SHC2,ACACB,IRS1,PRKAR1A,CBL,FOXO1,GYS2,TRIP10,RPS6KB1,FBP2,PRKAR2B,GCK,PYGM,G6PC1,PTPN1,PTPRF,PPP1CB,RAPGEF1,KRAS,PIK3CD,FBP1,PPP1CC,EIF4EBP1,SOCS2,PRKAR1B,PPP1R3A,PRKAG2,GRB2,AKT1,SREBF1,HKDC1,MAPK9,MTOR,BRAF,RHOQ,PHKB,PYGB,TSC2,RAF1,CALML4,SHC4,IRS2,SOCS1,PRKACG,PKLR,PHKG2,FLOT1,CALML3,PIK3CA,RPS6,CALML6,CALM3,PRKACB,INS,PRKCI,MAP2K1,MAPK3,SHC1,FLOT2,SORBS1,G6PC2,TSC1,PYGL,AKT2,SH2B2,CALML5,NRAS,AKT3,PRKAR2A,PDPK1,CALM2,CRK,PRKAG1,PRKAA1,PRKAA2,SHC3,HK3,EIF4E,MAPK1,MAP2K2
ko04910	Insulin signaling pathway	0.209902410740342	-1.56111256703645	138	125	0.0198412698412698	6300	7161	9021,8503,57521,5602,2194,5565,6009,5599,5140,3551,31,6517,5296,5499,3636,5291,3265,3098,868,2997,6654,79660,801,2872,2932,53632,3643,5507,5564,9470,51763,5105,23624,122809,6199,23265,10891,3991,5509,6655,2889,5500,5792,5770,2538,5837,2645,5577,8789,6198,9322,2998,2308,867,5573,3667,32,25759,5590,5295,5566,3099,92579,5568,8651,8660,399694,91860,5894,7249,5834,23433,5257,673,2475,5601,80201,6720,207,51422,2885,5575,5506,8835,1978,5501,2203,5293,3845,5594,5605,1977,3101,53358,5563,5562,5571,1398,805,5170,5576,10000,4893,51806,10603,5836,208,7248,57818,10580,2319,6464,5604,5595,5584,3630,808,5567,163688,6194,5290,810,10211,5261,5313	SOCS3,PIK3R3,RPTOR,MAPK10,FASN,PRKAB2,RHEB,MAPK8,PDE3B,IKBKB,ACACA,SLC2A4,PIK3R2,PPP1CA,INPPL1,PIK3CB,HRAS,HK1,CBLB,GYS1,SOS1,PPP1R3B,CALM1,MKNK2,GSK3B,PRKAG3,INSR,PPP1R3C,PRKAB1,EIF4E2,INPP5K,PCK1,CBLC,SOCS4,RPS6KB2,EXOC7,PPARGC1A,LIPE,PPP1R3D,SOS2,RAPGEF1,PPP1CB,PTPRF,PTPN1,G6PC1,PYGM,GCK,PRKAR2B,FBP2,RPS6KB1,TRIP10,GYS2,FOXO1,CBL,PRKAR1A,IRS1,ACACB,SHC2,PRKCZ,PIK3R1,PRKACA,HK2,G6PC3,PRKACG,SOCS1,IRS2,SHC4,CALML4,RAF1,TSC2,PYGB,RHOQ,PHKB,BRAF,MTOR,MAPK9,HKDC1,SREBF1,AKT1,PRKAG2,GRB2,PRKAR1B,PPP1R3A,SOCS2,EIF4EBP1,PPP1CC,FBP1,PIK3CD,KRAS,MAPK1,MAP2K2,EIF4E,HK3,SHC3,PRKAA2,PRKAA1,PRKAG1,CRK,CALM2,PDPK1,PRKAR2A,AKT3,NRAS,CALML5,SH2B2,PYGL,AKT2,TSC1,G6PC2,SORBS1,FLOT2,SHC1,MAP2K1,MAPK3,PRKCI,INS,CALM3,PRKACB,CALML6,RPS6,PIK3CA,CALML3,FLOT1,PHKG2,PKLR
hsa04723	Retrograde endocannabinoid signaling	0.211292143323272	-1.55451353761993	101	92	0.0146031746031746	6300	7161	2782,2893,2561,2783,22999,2911,2558,196883,5600,2566,3710,5579,108,113,3760,109,5566,54331,115,5330,2787,2793,2792,2770,222236,23236,2570,59345,5582,2890,2788,112,5602,5603,5599,3763,3762,776,2559,2565,107,2915,5332,2557,2773,2790,5578,2569,200959,775,246213,779,2555,773,5594,55970,5743,2791,3709,2567,2554,57084,5567,51764,3765,2562,2891,2563,57406,2786,114,747,5595,2776,6300,11343,5331,5568,10681,1432,2771,221955,2784,140679,1268,57030,2560,2568,94235,3708,5601,111	GNB1,GRIA4,GABRB2,GNB2,RIMS1,GRM1,GABRA5,ADCY4,MAPK11,GABRG2,ITPR3,PRKCB,ADCY2,ADCY7,KCNJ3,ADCY3,PRKACA,GNG2,ADCY9,PLCB2,GNG5,GNGT2,GNGT1,GNAI1,NAPEPLD,PLCB1,GABRR2,GNB4,PRKCG,GRIA1,GNG7,ADCY6,MAPK10,MAPK13,MAPK8,KCNJ6,KCNJ5,CACNA1D,GABRA6,GABRG1,ADCY1,GRM5,PLCB4,GABRA4,GNAI3,GNG10,PRKCA,GABRR1,GABRR3,CACNA1C,SLC17A8,CACNA1S,GABRA2,CACNA1A,MAPK1,GNG12,PTGS2,GNG11,ITPR2,GABRG3,GABRA1,SLC17A6,PRKACB,GNG13,KCNJ9,GABRB3,GRIA2,GABRD,ABHD6,GNG4,ADCY8,DAGLA,MAPK3,GNAQ,MAPK12,MGLL,PLCB3,PRKACG,GNB5,MAPK14,GNAI2,DAGLB,GNB3,SLC32A1,CNR1,SLC17A7,GABRB1,GABRP,GNG8,ITPR1,MAPK9,ADCY5
ko04723	Retrograde endocannabinoid signaling	0.211292143323272	-1.55451353761993	101	92	0.0146031746031746	6300	7161	5330,2793,2792,2770,2787,3760,113,54331,115,109,5566,2566,5579,3710,196883,5600,108,2782,2561,2893,22999,2783,2911,2558,5332,2773,2790,5578,2557,3763,3762,776,2559,2565,107,2915,5599,112,5602,5603,59345,222236,23236,2570,5582,2890,2788,114,2786,747,5595,3765,2554,57084,5567,51764,57406,2562,2563,2891,5743,5594,55970,2567,3709,2791,246213,2569,775,200959,779,773,2555,5601,3708,111,57030,1268,2784,140679,2560,2568,94235,5568,10681,5331,221955,1432,2771,11343,2776,6300	PLCB2,GNGT2,GNGT1,GNAI1,GNG5,KCNJ3,ADCY7,GNG2,ADCY9,ADCY3,PRKACA,GABRG2,PRKCB,ITPR3,ADCY4,MAPK11,ADCY2,GNB1,GABRB2,GRIA4,RIMS1,GNB2,GRM1,GABRA5,PLCB4,GNAI3,GNG10,PRKCA,GABRA4,KCNJ6,KCNJ5,CACNA1D,GABRA6,GABRG1,ADCY1,GRM5,MAPK8,ADCY6,MAPK10,MAPK13,GNB4,NAPEPLD,PLCB1,GABRR2,PRKCG,GRIA1,GNG7,ADCY8,GNG4,DAGLA,MAPK3,KCNJ9,GABRA1,SLC17A6,PRKACB,GNG13,ABHD6,GABRB3,GABRD,GRIA2,PTGS2,MAPK1,GNG12,GABRG3,ITPR2,GNG11,SLC17A8,GABRR1,CACNA1C,GABRR3,CACNA1S,CACNA1A,GABRA2,MAPK9,ITPR1,ADCY5,SLC17A7,CNR1,GNB3,SLC32A1,GABRB1,GABRP,GNG8,PRKACG,GNB5,PLCB3,DAGLB,MAPK14,GNAI2,MGLL,GNAQ,MAPK12
ko04141	Protein processing in endoplasmic reticulum	0.212287715627797	-1.54981277521699	165	149	0.0236507936507937	6300	7161	10956,56681,6745,440275,6184,6048,1650,64215,55741,7322,55757,7323,3998,8454,10299,3300,7841,10905,10802,23193,54431,29979,6185,51726,5886,4217,3703,55829,23471,7327,23645,596,1388,7466,9695,55768,22926,10294,9871,91319,9451,26232,10525,10427,6500,3320,10970,7095,1409,3337,26270,1965,10961,4780,80331,6400,100506742,9601,1603,143630,25956,823,7353,258010,10483,5601,5610,55176,79139,7415,3309,4121,6746,468,55968,581,9709,10277,267,7494,91445,5611,10952,573,29927,55432,6396,11231,57134,3305,578,9373,7326,85479,51619,22872,5887,3326,22824,10484,3304,80267,3312,56605,10130,2081,8720,30001,821,7321,10113,81567,54788,5602,64374,55666,4287,5599,51465,27102,80700,9978,1410,811,201595,23480,10960,118424,79748,5609,3306,51128,10808,9532,56893,80343,6747,824,5071,6238,7991,9632,3310,3301,5034,84447,5589,10273,56886	OS9,SAR1A,SSR1,EIF2AK4,RPN1,RNF5,DDOST,DNAJC1,EDEM2,UBE2D2,UGGT2,UBE2D3,LMAN1,CUL1,MARCHF6,DNAJB2,MOGS,MAN1A2,SEC24A,GANAB,DNAJC10,UBQLN1,RPN2,DNAJB11,RAD23A,MAP3K5,STT3A,SELENOS,TRAM1,UBE2G2,PPP1R15A,BCL2,ATF6B,WFS1,EDEM1,NGLY1,ATF6,DNAJA2,SEC24D,DERL3,EIF2AK3,FBXO2,HYOU1,SEC24B,SKP1,HSP90AA1,CKAP4,SEC62,CRYAA,DNAJB1,FBXO6,EIF2S1,ERP29,NFE2L2,DNAJC5,SEL1L,CASP12,PDIA4,DAD1,UBQLNL,SEC31B,CAPN1,UFD1,SVIP,SEC23B,MAPK9,EIF2AK2,SEC61A2,DERL1,VCP,HSPA5,MAN1A1,SSR2,ATF4,NSFL1C,BAX,HERPUD1,UBE4B,AMFR,XBP1,RNF185,DNAJC3,SEC61B,BAG1,SEC61A1,YOD1,SEC13,SEC63,MAN1C1,HSPA1L,BAK1,PLAA,UBE2G1,DNAJC5B,UBE2D4,SEC31A,RAD23B,HSP90AB1,HSPA4L,SEC23A,HSPA1B,EDEM3,HSPA8,ERO1B,PDIA6,ERN1,MBTPS1,ERO1A,CANX,UBE2D1,PREB,TXNDC5,DNAJB12,MAPK10,SIL1,NPLOC4,ATXN3,MAPK8,UBE2J1,EIF2AK1,UBXN6,RBX1,CRYAB,CALR,STT3B,SEC61G,LMAN2,UBE2J2,LMAN1L,MAP2K7,HSPA2,SAR1B,HSPH1,BAG2,UBQLN4,SEL1L2,SSR3,CAPN2,PRKN,RRBP1,TUSC3,SEC24C,HSPA6,DNAJA1,P4HB,SYVN1,PRKCSH,STUB1,UGGT1
hsa04141	Protein processing in endoplasmic reticulum	0.212287715627797	-1.54981277521699	165	149	0.0236507936507937	6300	7161	84447,5589,56886,10273,5034,3310,3301,9632,5071,6238,7991,824,6747,80343,56893,9532,10808,51128,5609,3306,118424,79748,23480,10960,811,201595,80700,9978,1410,27102,51465,5599,4287,5602,64374,55666,54788,81567,10113,7321,821,30001,10130,2081,8720,3312,56605,80267,10484,3304,22824,22872,3326,5887,51619,85479,7326,9373,578,11231,57134,3305,6396,55432,29927,573,10952,91445,5611,7494,9709,10277,267,581,55968,468,4121,6746,79139,3309,7415,55176,5601,10483,5610,258010,7353,823,143630,1603,25956,100506742,9601,6400,4780,80331,10961,3337,26270,1965,10970,7095,1409,6500,3320,26232,10525,10427,9451,91319,9871,10294,9695,22926,55768,7466,1388,596,23645,23471,7327,3703,55829,4217,5886,6185,51726,29979,23193,54431,10802,3300,10905,7841,10299,3998,8454,7322,7323,55757,55741,1650,64215,6048,440275,6184,6745,10956,56681	SYVN1,PRKCSH,UGGT1,STUB1,P4HB,HSPA6,DNAJA1,SEC24C,PRKN,RRBP1,TUSC3,CAPN2,SSR3,SEL1L2,UBQLN4,BAG2,HSPH1,SAR1B,MAP2K7,HSPA2,UBE2J2,LMAN1L,SEC61G,LMAN2,CALR,STT3B,UBXN6,RBX1,CRYAB,EIF2AK1,UBE2J1,MAPK8,ATXN3,MAPK10,SIL1,NPLOC4,DNAJB12,TXNDC5,PREB,UBE2D1,CANX,ERO1A,PDIA6,ERN1,MBTPS1,HSPA8,ERO1B,EDEM3,SEC23A,HSPA1B,HSPA4L,SEC31A,HSP90AB1,RAD23B,UBE2D4,DNAJC5B,UBE2G1,PLAA,BAK1,SEC63,MAN1C1,HSPA1L,SEC13,YOD1,SEC61A1,BAG1,SEC61B,RNF185,DNAJC3,XBP1,HERPUD1,UBE4B,AMFR,BAX,NSFL1C,ATF4,MAN1A1,SSR2,DERL1,HSPA5,VCP,SEC61A2,MAPK9,SEC23B,EIF2AK2,SVIP,UFD1,CAPN1,UBQLNL,DAD1,SEC31B,CASP12,PDIA4,SEL1L,NFE2L2,DNAJC5,ERP29,DNAJB1,FBXO6,EIF2S1,CKAP4,SEC62,CRYAA,SKP1,HSP90AA1,FBXO2,HYOU1,SEC24B,EIF2AK3,DERL3,SEC24D,DNAJA2,EDEM1,ATF6,NGLY1,WFS1,ATF6B,BCL2,PPP1R15A,TRAM1,UBE2G2,STT3A,SELENOS,MAP3K5,RAD23A,RPN2,DNAJB11,UBQLN1,GANAB,DNAJC10,SEC24A,DNAJB2,MAN1A2,MOGS,MARCHF6,LMAN1,CUL1,UBE2D2,UBE2D3,UGGT2,EDEM2,DDOST,DNAJC1,RNF5,EIF2AK4,RPN1,SSR1,OS9,SAR1A
hsa05203	Viral carcinogenesis	0.212548334245834	-1.54858586120718	201	181	0.0287301587301587	6300	7161	3716,3845,51564,9734,3134,468,581,6672,5293,9586,4055,5610,4790,7185,387,1959,894,55697,7337,2968,2960,8349,1019,90993,3661,1388,440689,5934,1234,5567,7529,8367,9114,5595,841,8348,8340,6850,6502,8363,8362,3106,9519,4893,64764,3018,2934,245972,5829,890,8850,8364,9134,1030,8370,10014,1029,387332,1237,998,5902,7188,10971,595,8339,1232,1960,1233,5933,5291,3265,5296,2965,5879,8970,3066,8503,2959,1111,8361,5566,9759,1385,8900,148327,578,2958,718,5922,8366,8345,983,3133,8379,5423,3107,728340,8841,10379,3017,1026,4067,23513,22938,7533,7532,6714,8717,2885,5925,8343,3105,1021,3665,8360,8368,3135,1017,8347,81,1387,5568,3249,121504,10488,2967,5290,9261,128312,6722,6777,896,85477,3572,2033,4792,1739,9093,836,5594,991,3516,5315,11036,23352,898,1027,6774,83933,5700,2957,5970,8346,8365,3190,8359,87,7531,84699,79885,1386,1642,1108,8341,3065,5366,5295,7157,3725,2961,27044,4193,6776,7187,7419,5966,7874,8344,4791,7534,3718	JAK1,KRAS,HDAC7,HDAC9,HLA-F,ATF4,BAX,SP100,PIK3CD,CREB5,LTBR,EIF2AK2,NFKB1,TRAF1,RHOA,EGR2,CCND2,VAC14,UBE3A,GTF2H4,GTF2E1,H2BC21,CDK4,CREB3L1,IRF3,ATF6B,H2BC18,RBL2,CCR5,PRKACB,YWHAB,H4C5,ATP6V0D1,MAPK3,CASP8,H2BC17,H2BC13,SYK,SKP2,H4C11,H4C12,HLA-B,TBPL1,NRAS,CREB3L2,H2BC3,GSN,ATP6V0D2,PXN,CCNA2,KAT2B,H4C3,CCNE2,CDKN2B,H4C14,HDAC5,CDKN2A,TBPL2,CCR8,CDC42,RANBP1,TRAF5,YWHAQ,CCND1,H2BC8,CCR3,EGR3,CCR4,RBL1,PIK3CB,HRAS,PIK3R2,GTF2H1,RAC1,H2BC11,HDAC2,PIK3R3,GTF2B,CHEK1,H4C6,PRKACA,HDAC4,CREB1,CCNA1,CREB3L4,BAK1,GTF2A2,C3,RASA2,H4C2,H2BC9,CDK1,HLA-E,MAD1L1,POLB,HLA-C,GTF2H2C,HDAC3,IRF9,H2BC5,CDKN1A,LYN,SCRIB,SNW1,YWHAH,YWHAG,SRC,TRADD,GRB2,RB1,H2BC7,HLA-A,CDK6,IRF7,H4C4,H4C13,HLA-G,CDK2,H2BC4,ACTN4,CREBBP,PRKACG,HPN,H4C16,CREB3,GTF2H3,PIK3CA,MAPKAPK2,H2BC26,SRF,STAT5B,CCND3,SCIN,IL6ST,EP300,NFKBIA,DLG1,DNAJA3,CASP3,MAPK1,CDC20,RBPJ,PKM,GTF2A1L,UBR4,CCNE1,CDKN1B,STAT3,HDAC10,PSMC1,GTF2A1,RELA,H2BC10,H4C8,HNRNPK,H4C1,ACTN1,YWHAE,CREB3L3,HDAC11,ATF2,DDB1,CHD4,H2BC15,HDAC1,PMAIP1,PIK3R1,TP53,JUN,GTF2E2,SND1,MDM2,STAT5A,TRAF3,VDAC3,REL,USP7,H2BC6,NFKB2,YWHAZ,JAK3
ko05203	Viral carcinogenesis	0.212548334245834	-1.54858586120718	201	181	0.0287301587301587	6300	7161	3516,5594,991,836,9093,1739,896,6777,6722,4792,2033,3572,85477,2967,9261,128312,5290,1387,10488,3249,121504,5568,1017,3135,8360,8368,3665,81,8347,5925,2885,8717,6714,7532,7533,22938,1021,3105,8343,1026,10379,3017,23513,4067,8344,7874,5966,7534,3718,4791,7419,7187,2961,3725,7157,6776,4193,27044,3065,5295,5366,79885,84699,7531,8341,1108,1642,1386,3190,8365,8346,5970,2957,87,8359,5700,11036,5315,83933,1027,6774,898,23352,2934,3018,64764,245972,3106,8362,8363,6502,4893,9519,5595,9114,8367,6850,8348,8340,841,1388,3661,90993,1234,5567,7529,5934,440689,8349,2960,2968,1019,7337,55697,894,1959,9586,387,7185,4790,5610,4055,51564,3845,3716,5293,6672,581,468,3134,9734,8841,728340,8379,3133,3107,5423,2958,718,5922,578,983,8345,8366,1385,9759,8361,5566,148327,8900,8970,2965,5879,5296,1111,2959,8503,3066,5933,1233,1960,1232,8339,595,10971,3265,5291,998,1237,387332,1029,7188,5902,8850,890,5829,10014,8370,9134,1030,8364	RBPJ,MAPK1,CDC20,CASP3,DNAJA3,DLG1,CCND3,STAT5B,SRF,NFKBIA,EP300,IL6ST,SCIN,GTF2H3,MAPKAPK2,H2BC26,PIK3CA,CREBBP,CREB3,HPN,H4C16,PRKACG,CDK2,HLA-G,H4C4,H4C13,IRF7,ACTN4,H2BC4,RB1,GRB2,TRADD,SRC,YWHAG,YWHAH,SNW1,CDK6,HLA-A,H2BC7,CDKN1A,IRF9,H2BC5,SCRIB,LYN,H2BC6,USP7,REL,YWHAZ,JAK3,NFKB2,VDAC3,TRAF3,GTF2E2,JUN,TP53,STAT5A,MDM2,SND1,HDAC1,PIK3R1,PMAIP1,HDAC11,CREB3L3,YWHAE,H2BC15,CHD4,DDB1,ATF2,HNRNPK,H4C8,H2BC10,RELA,GTF2A1,ACTN1,H4C1,PSMC1,GTF2A1L,PKM,HDAC10,CDKN1B,STAT3,CCNE1,UBR4,GSN,H2BC3,CREB3L2,ATP6V0D2,HLA-B,H4C12,H4C11,SKP2,NRAS,TBPL1,MAPK3,ATP6V0D1,H4C5,SYK,H2BC17,H2BC13,CASP8,ATF6B,IRF3,CREB3L1,CCR5,PRKACB,YWHAB,RBL2,H2BC18,H2BC21,GTF2E1,GTF2H4,CDK4,UBE3A,VAC14,CCND2,EGR2,CREB5,RHOA,TRAF1,NFKB1,EIF2AK2,LTBR,HDAC7,KRAS,JAK1,PIK3CD,SP100,BAX,ATF4,HLA-F,HDAC9,HDAC3,GTF2H2C,MAD1L1,HLA-E,HLA-C,POLB,GTF2A2,C3,RASA2,BAK1,CDK1,H2BC9,H4C2,CREB1,HDAC4,H4C6,PRKACA,CREB3L4,CCNA1,H2BC11,GTF2H1,RAC1,PIK3R2,CHEK1,GTF2B,PIK3R3,HDAC2,RBL1,CCR4,EGR3,CCR3,H2BC8,CCND1,YWHAQ,HRAS,PIK3CB,CDC42,CCR8,TBPL2,CDKN2A,TRAF5,RANBP1,KAT2B,CCNA2,PXN,HDAC5,H4C14,CCNE2,CDKN2B,H4C3
hsa04512	ECM-receptor interaction	0.214514537344252	-1.53937776974389	82	75	0.0119047619047619	6300	7161	6382,3694,1298,2335,3679,8516,3676,3371,3913,3912,6696,9899,2815,7143,22798,1284,3685,3688,3680,3655,7059,7060,3672,3673,3690,3695,1311,63923,9900,1285,1280,3911,3908,1277,2814,7450,1605,7057,961,1101,3674,1293,6385,1278,51206,131873,3691,948,1286,7058,3161,3696,3918,3910,3915,960,375790,3909,5649,7148,3339,3381,284217,22987,1299,3693,3675,1282,256076,1297,10319,8515,22801,3914,2811	SDC1,ITGB6,COL9A2,FN1,ITGA7,ITGA8,ITGA4,TNC,LAMB2,LAMB1,SPP1,SV2B,GP9,TNR,LAMB4,COL4A2,ITGAV,ITGB1,ITGA9,ITGA6,THBS3,THBS4,ITGA1,ITGA2,ITGB3,ITGB7,COMP,TNN,SV2A,COL4A3,COL2A1,LAMA5,LAMA2,COL1A1,GP5,VWF,DAG1,THBS1,CD47,CHAD,ITGA2B,COL6A3,SDC4,COL1A2,GP6,COL6A6,ITGB4,CD36,COL4A4,THBS2,HMMR,ITGB8,LAMC2,LAMA4,LAMC1,CD44,AGRN,LAMA3,RELN,TNXB,HSPG2,IBSP,LAMA1,SV2C,COL9A3,ITGB5,ITGA3,COL4A1,COL6A5,COL9A1,LAMC3,ITGA10,ITGA11,LAMB3,GP1BA
ko04512	ECM-receptor interaction	0.214514537344252	-1.53937776974389	82	75	0.0119047619047619	6300	7161	8515,22801,3914,2811,256076,1282,1297,10319,1299,22987,284217,3675,3693,3381,3909,375790,960,7148,5649,3339,3696,3918,3910,3915,3691,948,131873,7058,3161,1286,1278,6385,1293,3674,51206,7057,961,1101,1285,3908,1280,3911,63923,9900,7450,1605,1277,2814,7060,3690,3695,1311,3672,3673,3655,7059,2815,9899,3685,3688,3680,22798,1284,7143,3371,3676,3913,6696,3912,1298,6382,3694,8516,3679,2335	ITGA10,ITGA11,LAMB3,GP1BA,COL6A5,COL4A1,COL9A1,LAMC3,COL9A3,SV2C,LAMA1,ITGA3,ITGB5,IBSP,LAMA3,AGRN,CD44,TNXB,RELN,HSPG2,ITGB8,LAMC2,LAMA4,LAMC1,ITGB4,CD36,COL6A6,THBS2,HMMR,COL4A4,COL1A2,SDC4,COL6A3,ITGA2B,GP6,THBS1,CD47,CHAD,COL4A3,LAMA2,COL2A1,LAMA5,TNN,SV2A,VWF,DAG1,COL1A1,GP5,THBS4,ITGB3,ITGB7,COMP,ITGA1,ITGA2,ITGA6,THBS3,GP9,SV2B,ITGAV,ITGB1,ITGA9,LAMB4,COL4A2,TNR,TNC,ITGA4,LAMB2,SPP1,LAMB1,COL9A2,SDC1,ITGB6,ITGA8,ITGA7,FN1
M00388	ECS complex	0.214711271919904	-1.53846107468416	12	12	0.0019047619047619	6300	7161	9021,6921,8065,8651,6923,9306,122809,8835,9616,30837,1154,9655	SOCS3,ELOC,CUL5,SOCS1,ELOB,SOCS6,SOCS4,SOCS2,RNF7,SOCS7,CISH,SOCS5
hsa_M00388	ECS complex	0.214711271919904	-1.53846107468416	12	12	0.0019047619047619	6300	7161	9021,6921,8065,8651,6923,9306,122809,8835,9616,30837,1154,9655	SOCS3,ELOC,CUL5,SOCS1,ELOB,SOCS6,SOCS4,SOCS2,RNF7,SOCS7,CISH,SOCS5
hsa_M00094	Ceramide biosynthesis	0.214711271919904	-1.53846107468416	12	12	0.0019047619047619	6300	7161	2531,8560,79603,55304,10715,10558,29956,123099,253782,91012,9517,204219	KDSR,DEGS1,CERS4,SPTLC3,CERS1,SPTLC1,CERS2,DEGS2,CERS6,CERS5,SPTLC2,CERS3
M00094	Ceramide biosynthesis	0.214711271919904	-1.53846107468416	12	12	0.0019047619047619	6300	7161	9517,91012,10558,204219,29956,2531,8560,123099,10715,55304,79603,253782	SPTLC2,CERS5,SPTLC1,CERS3,CERS2,KDSR,DEGS1,DEGS2,CERS1,SPTLC3,CERS4,CERS6
hsa03060	Protein export	0.217189781067344	-1.52698374052206	23	22	0.00349206349206349	6300	7161	7095,6731,6727,29927,58477,3309,10952,23478,6730,55176,196294,83943,6726,23480,6734,11231,90701,6728,9789,60559,5018,6729	SEC62,SRP72,SRP14,SEC61A1,SRPRB,HSPA5,SEC61B,SEC11A,SRP68,SEC61A2,IMMP1L,IMMP2L,SRP9,SEC61G,SRPRA,SEC63,SEC11C,SRP19,SPCS2,SPCS3,OXA1L,SRP54
ko01040	Biosynthesis of unsaturated fatty acids	0.217189781067344	-1.52698374052206	23	22	0.00349206349206349	6300	7161	122970,570,51,9200,30,201562,8310,79071,51495,10965,9415,3030,11332,3992,401494,6319,9524,79966,54898,60481,55825,51144	ACOT4,BAAT,ACOX1,HACD1,ACAA1,HACD2,ACOX3,ELOVL6,HACD3,ACOT2,FADS2,HADHA,ACOT7,FADS1,HACD4,SCD,TECR,SCD5,ELOVL2,ELOVL5,PECR,HSD17B12
ko03060	Protein export	0.217189781067344	-1.52698374052206	23	22	0.00349206349206349	6300	7161	6734,55176,196294,3309,6731,58477,60559,6728,11231,6726,23480,83943,23478,10952,6730,7095,6727,29927,6729,5018,9789,90701	SRPRA,SEC61A2,IMMP1L,HSPA5,SRP72,SRPRB,SPCS3,SRP19,SEC63,SRP9,SEC61G,IMMP2L,SEC11A,SEC61B,SRP68,SEC62,SRP14,SEC61A1,SRP54,OXA1L,SPCS2,SEC11C
hsa01040	Biosynthesis of unsaturated fatty acids	0.217189781067344	-1.52698374052206	23	22	0.00349206349206349	6300	7161	9524,6319,401494,79966,55825,60481,51144,54898,3030,9415,3992,11332,8310,79071,51495,10965,570,9200,51,122970,201562,30	TECR,SCD,HACD4,SCD5,PECR,ELOVL5,HSD17B12,ELOVL2,HADHA,FADS2,FADS1,ACOT7,ACOX3,ELOVL6,HACD3,ACOT2,BAAT,HACD1,ACOX1,ACOT4,HACD2,ACAA1
ko05140	Leishmaniasis	0.221261349579806	-1.50841069887393	72	66	0.0104761904761905	6300	7161	7099,10454,4688,3458,9103,4792,4793,7097,3684,5595,3725,718,51135,2212,6772,6885,65108,5594,5600,3688,1535,5743,5579,23118,3118,7124,7042,3109,7043,3676,7189,3117,3717,3716,2214,3592,3593,3108,3111,5777,4790,3689,3122,3552,3586,3553,3123,3119,6300,4615,2215,4689,2353,3127,2209,5970,5603,3112,3460,3113,653361,7040,3565,3459,1432,1378	TLR4,TAB1,NCF2,IFNG,FCGR2C,NFKBIA,NFKBIB,TLR2,ITGAM,MAPK3,JUN,C3,IRAK4,FCGR2A,STAT1,MAP3K7,MARCKSL1,MAPK1,MAPK11,ITGB1,CYBA,PTGS2,PRKCB,TAB2,HLA-DQA2,TNF,TGFB2,HLA-DMB,TGFB3,ITGA4,TRAF6,HLA-DQA1,JAK2,JAK1,FCGR3A,IL12A,IL12B,HLA-DMA,HLA-DOA,PTPN6,NFKB1,ITGB2,HLA-DRA,IL1A,IL10,IL1B,HLA-DRB1,HLA-DQB1,MAPK12,MYD88,FCGR3B,NCF4,FOS,HLA-DRB5,FCGR1A,RELA,MAPK13,HLA-DOB,IFNGR2,HLA-DPA1,NCF1,TGFB1,IL4,IFNGR1,MAPK14,CR1
hsa05140	Leishmaniasis	0.221261349579806	-1.50841069887393	72	66	0.0104761904761905	6300	7161	7099,10454,4688,4792,4793,3458,9103,5595,3725,3684,718,51135,7097,2212,65108,6772,6885,5743,1535,23118,5579,3118,5594,5600,3688,3676,7189,7124,7042,3109,7043,3117,3717,2214,3716,5777,4790,3592,3593,3108,3111,3122,3552,3123,3553,3586,3119,3689,2353,6300,2215,4615,4689,2209,5970,3127,3112,3460,3113,653361,5603,1378,3565,7040,1432,3459	TLR4,TAB1,NCF2,NFKBIA,NFKBIB,IFNG,FCGR2C,MAPK3,JUN,ITGAM,C3,IRAK4,TLR2,FCGR2A,MARCKSL1,STAT1,MAP3K7,PTGS2,CYBA,TAB2,PRKCB,HLA-DQA2,MAPK1,MAPK11,ITGB1,ITGA4,TRAF6,TNF,TGFB2,HLA-DMB,TGFB3,HLA-DQA1,JAK2,FCGR3A,JAK1,PTPN6,NFKB1,IL12A,IL12B,HLA-DMA,HLA-DOA,HLA-DRA,IL1A,HLA-DRB1,IL1B,IL10,HLA-DQB1,ITGB2,FOS,MAPK12,FCGR3B,MYD88,NCF4,FCGR1A,RELA,HLA-DRB5,HLA-DOB,IFNGR2,HLA-DPA1,NCF1,MAPK13,CR1,IL4,TGFB1,MAPK14,IFNGR1
hsa04940	Type I diabetes mellitus	0.223073203438915	-1.50025529484747	43	40	0.00634920634920635	6300	7161	941,5799,2571,3134,3630,3117,3329,3558,3119,3123,3553,3122,3552,3002,1363,355,3105,3458,3111,3108,3593,3592,3133,3135,3106,940,3127,3382,3107,942,2572,5798,4049,3109,7124,3118,3113,3112,5551,356	CD80,PTPRN2,GAD1,HLA-F,INS,HLA-DQA1,HSPD1,IL2,HLA-DQB1,HLA-DRB1,IL1B,HLA-DRA,IL1A,GZMB,CPE,FAS,HLA-A,IFNG,HLA-DOA,HLA-DMA,IL12B,IL12A,HLA-E,HLA-G,HLA-B,CD28,HLA-DRB5,ICA1,HLA-C,CD86,GAD2,PTPRN,LTA,HLA-DMB,TNF,HLA-DQA2,HLA-DPA1,HLA-DOB,PRF1,FASLG
ko04940	Type I diabetes mellitus	0.223073203438915	-1.50025529484747	43	40	0.00634920634920635	6300	7161	3552,3122,3123,3553,3119,3558,3002,355,1363,3592,3593,3108,3458,3111,3105,941,5799,2571,3329,3117,3630,3134,7124,3109,5551,3112,3113,3118,356,3135,3106,3133,3382,940,3127,942,3107,4049,5798,2572	IL1A,HLA-DRA,HLA-DRB1,IL1B,HLA-DQB1,IL2,GZMB,FAS,CPE,IL12A,IL12B,HLA-DMA,IFNG,HLA-DOA,HLA-A,CD80,PTPRN2,GAD1,HSPD1,HLA-DQA1,INS,HLA-F,TNF,HLA-DMB,PRF1,HLA-DOB,HLA-DPA1,HLA-DQA2,FASLG,HLA-G,HLA-B,HLA-E,ICA1,CD28,HLA-DRB5,CD86,HLA-C,LTA,PTPRN,GAD2
ko04060	Cytokine-cytokine receptor interaction	0.227713583970604	-1.47966665037696	270	242	0.0384126984126984	6300	7161	282618,5154,3606,8744,268,282616,943,6355,939,6369,3624,3601,53833,55540,3449,6376,2920,3596,3456,1270,1524,958,1956,10803,4233,23765,338376,3574,3560,3568,27189,8797,7046,2688,8741,50615,3467,3626,3440,3448,8809,5156,3569,3604,970,8600,3576,1230,6360,6368,9966,8792,6374,8793,356,3594,3454,6347,1435,944,132014,355,3592,3593,1439,3452,6358,8794,6373,657,6372,7850,2826,3953,3952,84818,3559,3439,9547,90,84957,83729,3565,3627,149233,163702,53832,3445,11009,59067,3572,659,50616,3558,23529,3577,10913,8743,8742,5617,2919,4049,3588,650,1235,58985,6346,58191,7042,7043,1436,29949,85480,7292,6367,7293,6348,3442,3443,7424,388372,10663,53342,4050,3575,3586,608,1237,116379,3556,1232,1233,5155,27242,3460,6363,2829,4804,6362,3625,55801,6354,269,93,3567,8807,3791,3082,3595,3455,5196,3976,6375,2323,2322,2056,7133,7132,57007,6349,6356,10850,27190,6351,3554,2690,23495,10344,3605,414062,3562,115650,55504,1437,112744,6366,1441,3587,5618,5008,1236,6361,3578,3570,4055,10673,3552,729230,3553,50604,9180,8740,1489,4352,3441,8784,4982,2324,8795,6846,91,7048,7040,3459,2921,3815,5159,3566,1234,1271,1950,56832,5197,3977,643,6352,655,3458,4254,3590,56477,92,6370,7852,6387,6364,6357,80301,7423,3444,7422,56034,658,2057,8718,8200,10563,8995,3600,2321,7124,3579	IFNL1,PDGFA,IL18,TNFSF9,AMH,IFNL2,TNFRSF8,CCL8,CD27,CCL24,INHBA,IL15RA,IL20RB,IL17RB,IFNA16,CX3CL1,CXCL2,IL13,IFNB1,CNTF,CX3CR1,CD40,EGFR,CCR9,MET,IL17RA,IFNE,IL7,IL2RB,IL5RA,IL17C,TNFRSF10A,TGFBR1,GH1,TNFSF13,IL21R,IFNW1,INHBC,IFNA2,IFNA14,IL18R1,PDGFRA,IL6,TNFRSF9,CD70,TNFSF11,CXCL8,CCR1,CCL16,CCL23,TNFSF15,TNFRSF11A,CXCL5,TNFRSF10D,FASLG,IL12RB1,IFNAR1,CCL2,CSF1,TNFSF8,IL17RE,FAS,IL12A,IL12B,CSF2RB,IFNA21,CCL14,TNFRSF10C,CXCL11,BMPR1A,CXCL6,IL1R2,CCR10,LEPR,LEP,IL17RC,IL2RA,IFNA1,CXCL14,ACVR1,RELT,INHBE,IL4,CXCL10,IL23R,IFNLR1,IL20RA,IFNA8,IL24,IL21,IL6ST,BMPR2,IL22,IL2,CLCF1,CXCR1,EDAR,TNFSF10,TNFSF12,PRL,CXCL1,LTA,IL10RB,BMP2,CCR6,IL22RA1,CCL1,CXCL16,TGFB2,TGFB3,CSF1R,IL19,TSLP,TNFSF4,CCL22,TNFRSF4,CCL3,IFNA5,IFNA6,VEGFC,CCL4L1,CXCR6,IL17D,LTB,IL7R,IL10,TNFRSF17,CCR8,IL22RA2,IL1RAP,CCR3,CCR4,PDGFB,TNFRSF21,IFNGR2,CCL19,XCR1,NGFR,CCL18,INHBB,IL26,CCL7,AMHR2,ACVR2B,IL5,IL18RAP,KDR,HGF,IL12RB2,IFNAR2,PF4,LIF,XCL1,FLT3LG,FLT3,EPO,TNFRSF1B,TNFRSF1A,ACKR3,CCL3L1,CCL11,CCL27,IL17B,CCL4,IL1R1,GHR,TNFRSF13B,CCL26,IL17A,CCL3L3,IL3,TNFRSF13C,TNFRSF19,CSF2,IL17F,CCL21,CSF3R,IL10RA,PRLR,OSM,CCR7,CCL17,IL9,IL6R,LTBR,TNFSF13B,IL1A,CCR2,IL1B,IL20,OSMR,TNFSF14,CTF1,MPL,IFNA4,TNFRSF18,TNFRSF11B,FLT4,TNFRSF10B,XCL2,ACVR1B,TGFBR2,TGFB1,IFNGR1,CXCL3,KIT,PDGFRB,IL4R,CCR5,CNTFR,EGF,IFNK,PF4V1,LIFR,CXCR5,CCL5,BMP7,IFNG,KITLG,IL11RA,CCL28,ACVR2A,CCL25,CXCR4,CXCL12,CCL20,CCL13,PLEKHO2,VEGFB,IFNA7,VEGFA,PDGFC,BMPR1B,EPOR,TNFRSF25,GDF5,CXCL13,TNFSF18,IL15,FLT1,TNF,CXCR2
hsa04060	Cytokine-cytokine receptor interaction	0.227713583970604	-1.47966665037696	270	242	0.0384126984126984	6300	7161	1436,7293,7292,6367,85480,29949,3443,7424,3442,6348,388372,10663,3575,4050,53342,3586,116379,1237,608,3556,5155,1233,1232,27242,2829,4804,6362,6363,3460,55801,3625,6354,269,3567,93,8807,3791,3082,3455,3595,6375,3976,5196,2322,2323,7132,2056,7133,6349,57007,6356,10850,6351,27190,10344,23495,2690,3554,414062,3605,3562,115650,1437,55504,6366,1441,112744,5008,5618,3587,4055,3578,3570,6361,1236,9180,50604,729230,3553,10673,3552,8740,1489,8784,4352,3441,4982,2324,6846,8795,3459,7040,7048,91,3566,5159,3815,2921,1234,1950,1271,3977,5197,56832,3590,56477,3458,4254,655,643,6352,6370,92,6364,7852,6387,7422,7423,3444,6357,80301,2057,658,56034,8200,8718,10563,2321,8995,3600,3579,7124,282618,3606,5154,268,8744,943,282616,939,6355,3624,6369,3601,55540,53833,6376,2920,3449,1270,3456,3596,958,1524,1956,4233,23765,10803,338376,3574,27189,3568,3560,7046,8797,3467,50615,8741,2688,3626,3440,3448,8809,3604,3569,5156,970,8600,1230,3576,9966,6360,6368,356,8793,6374,8792,6347,3454,3594,1435,944,132014,355,6358,1439,3593,3452,3592,6372,657,6373,8794,7850,2826,3952,3953,3439,3559,84818,90,9547,84957,3565,83729,149233,3627,53832,163702,11009,3445,3572,59067,3558,50616,659,23529,8742,8743,3577,10913,650,3588,5617,2919,4049,1235,6346,58985,58191,7043,7042	CSF1R,TNFRSF4,TNFSF4,CCL22,TSLP,IL19,IFNA6,VEGFC,IFNA5,CCL3,CCL4L1,CXCR6,IL7R,LTB,IL17D,IL10,IL22RA2,CCR8,TNFRSF17,IL1RAP,PDGFB,CCR4,CCR3,TNFRSF21,XCR1,NGFR,CCL18,CCL19,IFNGR2,IL26,INHBB,CCL7,AMHR2,IL5,ACVR2B,IL18RAP,KDR,HGF,IFNAR2,IL12RB2,XCL1,LIF,PF4,FLT3,FLT3LG,TNFRSF1A,EPO,TNFRSF1B,CCL3L1,ACKR3,CCL11,CCL27,CCL4,IL17B,CCL26,TNFRSF13B,GHR,IL1R1,CCL3L3,IL17A,IL3,TNFRSF13C,CSF2,TNFRSF19,CCL21,CSF3R,IL17F,OSM,PRLR,IL10RA,LTBR,IL9,IL6R,CCL17,CCR7,OSMR,IL20,CCR2,IL1B,TNFSF13B,IL1A,TNFSF14,CTF1,TNFRSF18,MPL,IFNA4,TNFRSF11B,FLT4,XCL2,TNFRSF10B,IFNGR1,TGFB1,TGFBR2,ACVR1B,IL4R,PDGFRB,KIT,CXCL3,CCR5,EGF,CNTFR,LIFR,PF4V1,IFNK,IL11RA,CCL28,IFNG,KITLG,BMP7,CXCR5,CCL5,CCL25,ACVR2A,CCL20,CXCR4,CXCL12,VEGFA,VEGFB,IFNA7,CCL13,PLEKHO2,EPOR,BMPR1B,PDGFC,GDF5,TNFRSF25,CXCL13,FLT1,TNFSF18,IL15,CXCR2,TNF,IFNL1,IL18,PDGFA,AMH,TNFSF9,TNFRSF8,IFNL2,CD27,CCL8,INHBA,CCL24,IL15RA,IL17RB,IL20RB,CX3CL1,CXCL2,IFNA16,CNTF,IFNB1,IL13,CD40,CX3CR1,EGFR,MET,IL17RA,CCR9,IFNE,IL7,IL17C,IL5RA,IL2RB,TGFBR1,TNFRSF10A,IFNW1,IL21R,TNFSF13,GH1,INHBC,IFNA2,IFNA14,IL18R1,TNFRSF9,IL6,PDGFRA,CD70,TNFSF11,CCR1,CXCL8,TNFSF15,CCL16,CCL23,FASLG,TNFRSF10D,CXCL5,TNFRSF11A,CCL2,IFNAR1,IL12RB1,CSF1,TNFSF8,IL17RE,FAS,CCL14,CSF2RB,IL12B,IFNA21,IL12A,CXCL6,BMPR1A,CXCL11,TNFRSF10C,IL1R2,CCR10,LEP,LEPR,IFNA1,IL2RA,IL17RC,ACVR1,CXCL14,RELT,IL4,INHBE,IL23R,CXCL10,IL20RA,IFNLR1,IL24,IFNA8,IL6ST,IL21,IL2,IL22,BMPR2,CLCF1,TNFSF12,TNFSF10,CXCR1,EDAR,BMP2,IL10RB,PRL,CXCL1,LTA,CCR6,CCL1,IL22RA1,CXCL16,TGFB3,TGFB2
hsa00590	Arachidonic acid metabolism	0.227894893030559	-1.47887075179878	62	57	0.00904761904761905	6300	7161	6916,1557,4048,26279,2876,1559,2880,2877,11145,391013,240,5320,80142,239,10728,151056,9536,30814,113612,64600,2687,5740,81579,2678,257202,8398,5321,50487,246,100137049,123745,242,8529,127281,2882,1579,2053,5319,8644,493869,247,5322,27306,8605,874,255189,2878,4056,1573,5743,5742,283748,11283,84647,1558,1555,873	TBXAS1,CYP2C19,LTA4H,PLA2G2D,GPX1,CYP2C9,GPX5,GPX2,PLAAT3,PLA2G2C,ALOX5,PLA2G2A,PTGES2,ALOX12,PTGES3,PLB1,PTGES,PLA2G2E,CYP2U1,PLA2G2F,GGT5,PTGIS,PLA2G12A,GGT1,GPX6,PLA2G6,PLA2G4A,PLA2G3,ALOX15,PLA2G4B,PLA2G4E,ALOX12B,CYP4F2,PRXL2B,GPX7,CYP4A11,EPHX2,PLA2G1B,AKR1C3,GPX8,ALOX15B,PLA2G5,HPGDS,PLA2G4C,CBR3,PLA2G4F,GPX3,LTC4S,CYP2J2,PTGS2,PTGS1,PLA2G4D,CYP4F8,PLA2G12B,CYP2C8,CYP2B6,CBR1
ko00590	Arachidonic acid metabolism	0.227894893030559	-1.47887075179878	62	57	0.00904761904761905	6300	7161	100137049,246,50487,5321,8398,2053,1579,2882,242,8529,127281,123745,255189,2878,4056,874,8605,5322,27306,5319,493869,8644,247,1558,84647,11283,873,1555,283748,5743,5742,1573,4048,26279,1557,6916,391013,240,2877,11145,2880,1559,2876,64600,113612,9536,30814,10728,151056,239,80142,5320,257202,2678,2687,5740,81579	PLA2G4B,ALOX15,PLA2G3,PLA2G4A,PLA2G6,EPHX2,CYP4A11,GPX7,ALOX12B,CYP4F2,PRXL2B,PLA2G4E,PLA2G4F,GPX3,LTC4S,CBR3,PLA2G4C,PLA2G5,HPGDS,PLA2G1B,GPX8,AKR1C3,ALOX15B,CYP2C8,PLA2G12B,CYP4F8,CBR1,CYP2B6,PLA2G4D,PTGS2,PTGS1,CYP2J2,LTA4H,PLA2G2D,CYP2C19,TBXAS1,PLA2G2C,ALOX5,GPX2,PLAAT3,GPX5,CYP2C9,GPX1,PLA2G2F,CYP2U1,PTGES,PLA2G2E,PTGES3,PLB1,ALOX12,PTGES2,PLA2G2A,GPX6,GGT1,GGT5,PTGIS,PLA2G12A
M00689	MAPK (p38) signaling	0.238794516328379	-1.43215186117636	22	21	0.00333333333333333	6300	7161	4217,4294,1432,4216,10746,1326,5603,57551,5608,4293,5600,51347,5606,4296,84451,4215,6885,4214,6300,9344,9064	MAP3K5,MAP3K10,MAPK14,MAP3K4,MAP3K2,MAP3K8,MAPK13,TAOK1,MAP2K6,MAP3K9,MAPK11,TAOK3,MAP2K3,MAP3K11,MAP3K21,MAP3K3,MAP3K7,MAP3K1,MAPK12,TAOK2,MAP3K6
hsa_M00689	MAPK (p38) signaling	0.238794516328379	-1.43215186117636	22	21	0.00333333333333333	6300	7161	5606,4296,84451,4215,6885,4214,9344,6300,9064,4217,4294,1432,4216,10746,1326,5603,57551,4293,51347,5608,5600	MAP2K3,MAP3K11,MAP3K21,MAP3K3,MAP3K7,MAP3K1,TAOK2,MAPK12,MAP3K6,MAP3K5,MAP3K10,MAPK14,MAP3K4,MAP3K2,MAP3K8,MAPK13,TAOK1,MAP3K9,TAOK3,MAP2K6,MAPK11
M00130	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	0.238794516328379	-1.43215186117636	22	21	0.00333333333333333	6300	7161	55300,5298,8395,3707,80271,23236,3706,89869,138429,8394,51196,5336,5335,5330,5332,5333,5331,5297,84812,55361,23396	PI4K2B,PI4KB,PIP5K1B,ITPKB,ITPKC,PLCB1,ITPKA,PLCZ1,PIP5KL1,PIP5K1A,PLCE1,PLCG2,PLCG1,PLCB2,PLCB4,PLCD1,PLCB3,PI4KA,PLCD4,PI4K2A,PIP5K1C
hsa_M00009	Citrate cycle (TCA cycle, Krebs cycle)	0.238794516328379	-1.43215186117636	22	21	0.00333333333333333	6300	7161	6389,4967,3418,1738,3419,3420,3417,48,4191,4190,6391,8801,6390,8802,50,8803,2271,1743,55753,1431,6392	SDHA,OGDH,IDH2,DLD,IDH3A,IDH3B,IDH1,ACO1,MDH2,MDH1,SDHC,SUCLG2,SDHB,SUCLG1,ACO2,SUCLA2,FH,DLST,OGDHL,CS,SDHD
hsa_M00130	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	0.238794516328379	-1.43215186117636	22	21	0.00333333333333333	6300	7161	80271,23236,3707,8395,5298,55300,5336,8394,51196,89869,138429,3706,5331,5297,5333,5332,5330,5335,23396,55361,84812	ITPKC,PLCB1,ITPKB,PIP5K1B,PI4KB,PI4K2B,PLCG2,PIP5K1A,PLCE1,PLCZ1,PIP5KL1,ITPKA,PLCB3,PI4KA,PLCD1,PLCB4,PLCB2,PLCG1,PIP5K1C,PI4K2A,PLCD4
M00009	Citrate cycle (TCA cycle, Krebs cycle)	0.238794516328379	-1.43215186117636	22	21	0.00333333333333333	6300	7161	6391,8801,6390,8802,2271,8803,50,1743,1431,55753,6392,3417,48,4191,4190,1738,3419,3420,6389,4967,3418	SDHC,SUCLG2,SDHB,SUCLG1,FH,SUCLA2,ACO2,DLST,CS,OGDHL,SDHD,IDH1,ACO1,MDH2,MDH1,DLD,IDH3A,IDH3B,SDHA,OGDH,IDH2
M00678	Hedgehog signaling	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	51684,6608,6469,374654,2735,2736,5727,27148,2737,50846,3549	SUFU,SMO,SHH,KIF7,GLI1,GLI2,PTCH1,STK36,GLI3,DHH,IHH
M00098	Acylglycerol degradation	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	5407,1056,5406,8513,9388,119548,5408,3990,57104,80339,11343	PNLIPRP1,CEL,PNLIP,LIPF,LIPG,PNLIPRP3,PNLIPRP2,LIPC,PNPLA2,PNPLA3,MGLL
hsa_M00098	Acylglycerol degradation	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	5408,119548,9388,5407,11343,80339,57104,8513,5406,3990,1056	PNLIPRP2,PNLIPRP3,LIPG,PNLIPRP1,MGLL,PNPLA3,PNPLA2,LIPF,PNLIP,LIPC,CEL
M00143	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	374291,4729,4726,4724,4719,4725,4728,4720,4722,4723,4731	NDUFS7,NDUFV2,NDUFS6,NDUFS4,NDUFS1,NDUFS5,NDUFS8,NDUFS2,NDUFS3,NDUFV1,NDUFV3
hsa_M00034	Methionine salvage pathway	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	6898,6723,84245,58478,27430,51074,55256,262,4144,4507,4143	TAT,SRM,MRI1,ENOPH1,MAT2B,APIP,ADI1,AMD1,MAT2A,MTAP,MAT1A
M00034	Methionine salvage pathway	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	4144,262,6723,84245,6898,51074,55256,27430,4143,4507,58478	MAT2A,AMD1,SRM,MRI1,TAT,APIP,ADI1,MAT2B,MAT1A,MTAP,ENOPH1
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	3242,154807,1728,6898,84274,51805,10229,27235,79001,2677,51004	HPD,VKORC1L1,NQO1,TAT,COQ5,COQ3,COQ7,COQ2,VKORC1,GGCX,COQ6
hsa_M00404	COPII complex	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	51128,9871,25956,56681,10802,10427,10484,10483,22872,6396,9632	SAR1B,SEC24D,SEC31B,SAR1A,SEC24A,SEC24B,SEC23A,SEC23B,SEC31A,SEC13,SEC24C
hsa_M00143	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	4731,4726,374291,4720,4728,4725,4719,4723,4722,4724,4729	NDUFV3,NDUFS6,NDUFS7,NDUFS2,NDUFS8,NDUFS5,NDUFS1,NDUFV1,NDUFS3,NDUFS4,NDUFV2
ko00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	3242,1728,84274,6898,154807,51805,10229,27235,79001,2677,51004	HPD,NQO1,COQ5,TAT,VKORC1L1,COQ3,COQ7,COQ2,VKORC1,GGCX,COQ6
ko00430	Taurine and hypotaurine metabolism	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	2687,570,2678,2686,1036,124975,51380,2571,84890,2572,339896	GGT5,BAAT,GGT1,GGT7,CDO1,GGT6,CSAD,GAD1,ADO,GAD2,GADL1
hsa00430	Taurine and hypotaurine metabolism	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	2678,84890,2572,570,2571,2687,51380,124975,339896,2686,1036	GGT1,ADO,GAD2,BAAT,GAD1,GGT5,CSAD,GGT6,GADL1,GGT7,CDO1
M00404	COPII complex	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	25956,56681,9871,51128,10802,10483,22872,10484,10427,6396,9632	SEC31B,SAR1A,SEC24D,SAR1B,SEC24A,SEC23B,SEC31A,SEC23A,SEC24B,SEC13,SEC24C
hsa_M00678	Hedgehog signaling	0.244106470698843	-1.41015079354111	11	11	0.00174603174603175	6300	7161	6469,374654,6608,2737,27148,2735,3549,50846,2736,5727,51684	SHH,KIF7,SMO,GLI3,STK36,GLI1,IHH,DHH,GLI2,PTCH1,SUFU
hsa04919	Thyroid hormone signaling pathway	0.246313810517355	-1.40114890349357	116	105	0.0166666666666667	6300	7161	488,5604,5595,5335,2033,480,5469,8648,1733,9440,7068,5290,5567,3091,3690,2099,2626,6256,5208,117247,54361,5594,5605,478,483,208,6772,4853,4893,10000,29079,9969,5170,477,207,6714,482,10025,23389,1499,116931,3845,9442,5293,1827,7249,5894,1387,5568,5331,5214,2475,4609,652,8202,5336,7157,5350,5330,2308,4193,53919,3065,89869,5566,5295,84812,9611,842,5579,60,8841,3685,10231,9882,51196,5578,90390,5332,5333,2932,6513,8850,1735,4854,486,6258,6548,10499,5296,6009,476,481,71,8503,3066,5582,595,4855,25942,4624,1734,23236,3265,5291	ATP2A2,MAP2K1,MAPK3,PLCG1,EP300,ATP1A4,MED1,NCOA1,DIO1,MED17,THRB,PIK3CA,PRKACB,HIF1A,ITGB3,ESR1,GATA4,RXRA,PFKFB2,SLC16A10,WNT4,MAPK1,MAP2K2,ATP1A3,ATP1B3,AKT2,STAT1,NOTCH2,NRAS,AKT3,MED4,MED13,PDPK1,ATP1A2,AKT1,SRC,ATP1B2,MED16,MED13L,CTNNB1,MED12L,KRAS,MED27,PIK3CD,RCAN1,TSC2,RAF1,CREBBP,PRKACG,PLCB3,PFKP,MTOR,MYC,BMP4,NCOA3,PLCG2,TP53,PLN,PLCB2,FOXO1,MDM2,SLCO1C1,HDAC1,PLCZ1,PRKACA,PIK3R1,PLCD4,NCOR1,CASP9,PRKCB,ACTB,HDAC3,ITGAV,RCAN2,TBC1D4,PLCE1,PRKCA,MED30,PLCB4,PLCD1,GSK3B,SLC2A1,KAT2B,DIO3,NOTCH3,FXYD2,RXRG,SLC9A1,NCOA2,PIK3R2,RHEB,ATP1A1,ATP1B1,ACTG1,PIK3R3,HDAC2,PRKCG,CCND1,NOTCH4,SIN3A,MYH6,DIO2,PLCB1,HRAS,PIK3CB
hsa04514	Cell adhesion molecules (CAMs)	0.247266773101884	-1.39728747214776	143	129	0.0204761904761905	6300	7161	3695,9672,214,6401,3384,23308,4685,57555,49861,7412,3655,1462,5797,947,8174,3684,257194,5175,80380,5792,24146,3107,4684,942,4756,3385,8516,926,3133,10666,1272,5010,3685,914,9379,23562,4099,3109,1002,3676,1003,9071,965,644672,6404,3111,933,3108,5788,9019,7122,50848,9076,100506658,9378,64101,3123,3122,53842,25945,958,940,3127,999,6385,58494,57689,149461,1000,3696,6693,5818,84628,90952,23705,201633,941,4897,137075,1001,9369,83700,22871,26285,6403,6402,80381,1366,57863,6382,3106,6383,51208,3688,6614,3680,100132463,3118,94030,3134,3117,923,4359,23114,79679,3105,10686,22854,1365,9080,6900,3689,1013,26047,3119,5819,9073,3383,3135,29126,2734,3683,3113,3112,1493,1364,920,5817,29851	ITGB7,SDC3,ALCAM,SELE,ICAM2,ICOSLG,NCAM2,NLGN2,CLDN20,VCAM1,ITGA6,VCAN,PTPRM,CD34,MADCAM1,ITGAM,NEGR1,PECAM1,PDCD1LG2,PTPRF,CLDN15,HLA-C,NCAM1,CD86,NEO1,ICAM3,ITGA8,CD8B,HLA-E,CD226,CNTN1,CLDN11,ITGAV,CD2,NRXN2,CLDN14,MAG,HLA-DMB,CDH4,ITGA4,CDH5,CLDN10,CD58,CLDN25,SELPLG,HLA-DOA,CD22,HLA-DMA,PTPRC,MPZL1,CLDN5,F11R,CLDN1,OCLN,NRXN1,LRRC4,HLA-DRB1,HLA-DRA,CLDN22,NECTIN3,CD40,CD28,HLA-DRB5,CDH1,SDC4,JAM2,LRRC4C,CLDN19,CDH2,ITGB8,SPN,NECTIN1,NTNG2,ESAM,CADM1,TIGIT,CD80,NRCAM,CLDN23,CDH3,NRXN3,JAM3,NLGN1,CLDN17,SELP,SELL,CD276,CLDN7,CADM3,SDC1,HLA-B,SDC2,CLDN18,ITGB1,SIGLEC1,ITGA9,CLDN24,HLA-DQA2,LRRC4B,HLA-F,HLA-DQA1,CD6,MPZ,NFASC,VTCN1,HLA-A,CLDN16,NTNG1,CLDN3,CLDN9,CNTN2,ITGB2,CDH15,CNTNAP2,HLA-DQB1,NECTIN2,CLDN8,ICAM1,HLA-G,CD274,GLG1,ITGAL,HLA-DPA1,HLA-DOB,CTLA4,CLDN4,CD4,PVR,ICOS
ko04514	Cell adhesion molecules (CAMs)	0.247266773101884	-1.39728747214776	143	129	0.0204761904761905	6300	7161	4897,137075,1001,9369,83700,6693,5818,84628,90952,23705,201633,941,3680,3688,6614,51208,100132463,3118,94030,22871,6403,26285,6402,80381,1366,57863,6382,3106,6383,3105,10686,22854,1365,9080,6900,3689,1013,26047,3119,3134,3117,923,4359,23114,79679,2734,29126,3683,3113,3112,1493,1364,920,29851,5817,5819,9073,3383,3135,1462,947,5797,8174,3684,3695,9672,214,6401,3384,23308,4685,57555,49861,3655,7412,914,3685,5010,9379,23562,4099,3109,1002,3676,1003,5175,257194,80380,5792,24146,942,4684,4756,3107,3385,926,8516,3133,10666,1272,3111,933,3108,5788,9019,50848,7122,9076,100506658,9378,64101,3123,3122,9071,965,644672,6404,58494,57689,149461,1000,3696,53842,25945,958,3127,940,999,6385	NRCAM,CLDN23,CDH3,NRXN3,JAM3,SPN,NECTIN1,NTNG2,ESAM,CADM1,TIGIT,CD80,ITGA9,ITGB1,SIGLEC1,CLDN18,CLDN24,HLA-DQA2,LRRC4B,NLGN1,SELP,CLDN17,SELL,CD276,CLDN7,CADM3,SDC1,HLA-B,SDC2,HLA-A,CLDN16,NTNG1,CLDN3,CLDN9,CNTN2,ITGB2,CDH15,CNTNAP2,HLA-DQB1,HLA-F,HLA-DQA1,CD6,MPZ,NFASC,VTCN1,GLG1,CD274,ITGAL,HLA-DPA1,HLA-DOB,CTLA4,CLDN4,CD4,ICOS,PVR,NECTIN2,CLDN8,ICAM1,HLA-G,VCAN,CD34,PTPRM,MADCAM1,ITGAM,ITGB7,SDC3,ALCAM,SELE,ICAM2,ICOSLG,NCAM2,NLGN2,CLDN20,ITGA6,VCAM1,CD2,ITGAV,CLDN11,NRXN2,CLDN14,MAG,HLA-DMB,CDH4,ITGA4,CDH5,PECAM1,NEGR1,PDCD1LG2,PTPRF,CLDN15,CD86,NCAM1,NEO1,HLA-C,ICAM3,CD8B,ITGA8,HLA-E,CD226,CNTN1,HLA-DOA,CD22,HLA-DMA,PTPRC,MPZL1,F11R,CLDN5,CLDN1,OCLN,NRXN1,LRRC4,HLA-DRB1,HLA-DRA,CLDN10,CD58,CLDN25,SELPLG,JAM2,LRRC4C,CLDN19,CDH2,ITGB8,CLDN22,NECTIN3,CD40,HLA-DRB5,CD28,CDH1,SDC4
ko05110	Vibrio cholerae infection	0.249395742540636	-1.3887143166893	51	47	0.00746031746031746	6300	7161	375,10952,155066,29927,526,127124,90423,245972,60,5566,51382,109,10945,115,5567,30001,50617,9114,2778,9550,7082,5335,9414,5336,23545,23480,528,8992,3784,1080,51606,71,11015,5568,55176,245973,523,11014,529,10312,525,4583,6558,9601,5578,533,535	ARF1,SEC61B,ATP6V0E2,SEC61A1,ATP6V1B2,ATP6V1G3,ATP6V1E2,ATP6V0D2,ACTB,PRKACA,ATP6V1D,ADCY3,KDELR1,ADCY9,PRKACB,ERO1A,ATP6V0A4,ATP6V0D1,GNAS,ATP6V1G1,TJP1,PLCG1,TJP2,PLCG2,ATP6V0A2,SEC61G,ATP6V1C1,ATP6V0E1,KCNQ1,CFTR,ATP6V1H,ACTG1,KDELR3,PRKACG,SEC61A2,ATP6V1C2,ATP6V1A,KDELR2,ATP6V1E1,TCIRG1,ATP6V1B1,MUC2,SLC12A2,PDIA4,PRKCA,ATP6V0B,ATP6V0A1
hsa05110	Vibrio cholerae infection	0.249395742540636	-1.3887143166893	51	47	0.00746031746031746	6300	7161	525,523,11014,529,10312,55176,245973,535,5578,533,4583,6558,9601,23480,23545,9414,5336,11015,5568,3784,1080,51606,71,528,8992,30001,5567,115,51382,5566,109,10945,5335,2778,7082,9550,50617,9114,526,29927,375,155066,10952,60,90423,245972,127124	ATP6V1B1,ATP6V1A,KDELR2,ATP6V1E1,TCIRG1,SEC61A2,ATP6V1C2,ATP6V0A1,PRKCA,ATP6V0B,MUC2,SLC12A2,PDIA4,SEC61G,ATP6V0A2,TJP2,PLCG2,KDELR3,PRKACG,KCNQ1,CFTR,ATP6V1H,ACTG1,ATP6V1C1,ATP6V0E1,ERO1A,PRKACB,ADCY9,ATP6V1D,PRKACA,ADCY3,KDELR1,PLCG1,GNAS,TJP1,ATP6V1G1,ATP6V0A4,ATP6V0D1,ATP6V1B2,SEC61A1,ARF1,ATP6V0E2,SEC61B,ACTB,ATP6V1E2,ATP6V0D2,ATP6V1G3
hsa04610	Complement and coagulation cascades	0.250768602200168	-1.38322466864981	79	72	0.0114285714285714	6300	7161	719,2266,1191,713,732,3053,3075,715,2149,966,2147,10544,2159,722,714,2151,2165,1604,2160,1361,5329,1380,727,5627,629,623,3818,2244,731,5340,5345,462,718,3684,7056,7450,4153,5648,3426,2153,710,5327,2152,624,7035,2243,717,5265,730,5328,5055,1675,4179,1378,728,2162,720,5104,729,5054,725,3687,716,712,3689,3827,735,2,2155,2161,10747,5624	C3AR1,FGG,CLU,C1QB,C8B,SERPIND1,CFH,C1R,F2R,CD59,F2,PROCR,F10,C4BPA,C1QC,F2RL2,F13B,CD55,F11,CPB2,PLAUR,CR2,C5,PROS1,CFB,BDKRB1,KLKB1,FGB,C8A,PLG,SERPINF2,SERPINC1,C3,ITGAM,THBD,VWF,MBL2,MASP1,CFI,F5,SERPING1,PLAT,F3,BDKRB2,TFPI,FGA,C2,SERPINA1,C7,PLAU,SERPINB2,CFD,CD46,CR1,C5AR1,F13A1,C4A,SERPINA5,C6,SERPINE1,C4BPB,ITGAX,C1S,C1QA,ITGB2,KNG1,C9,A2M,F7,F12,MASP2,PROC
ko04610	Complement and coagulation cascades	0.250768602200168	-1.38322466864981	79	72	0.0114285714285714	6300	7161	5104,720,2162,728,4179,1378,5055,1675,5328,730,5265,2243,717,7035,5624,10747,2161,2155,2,735,3827,3689,712,716,3687,725,5054,729,1361,2160,1604,2165,2151,714,722,2159,10544,2147,966,2149,715,3075,3053,732,713,1191,719,2266,710,624,2152,5327,2153,3426,5648,4153,7450,7056,3684,718,462,5345,731,2244,5340,3818,623,629,5627,727,1380,5329	SERPINA5,C4A,F13A1,C5AR1,CD46,CR1,SERPINB2,CFD,PLAU,C7,SERPINA1,FGA,C2,TFPI,PROC,MASP2,F12,F7,A2M,C9,KNG1,ITGB2,C1QA,C1S,ITGAX,C4BPB,SERPINE1,C6,CPB2,F11,CD55,F13B,F2RL2,C1QC,C4BPA,F10,PROCR,F2,CD59,F2R,C1R,CFH,SERPIND1,C8B,C1QB,CLU,C3AR1,FGG,SERPING1,BDKRB2,F3,PLAT,F5,CFI,MASP1,MBL2,VWF,THBD,ITGAM,C3,SERPINC1,SERPINF2,C8A,FGB,PLG,KLKB1,BDKRB1,CFB,PROS1,C5,CR2,PLAUR
hsa04070	Phosphatidylinositol signaling system	0.255181191206369	-1.36578143239704	97	88	0.013968253968254	6300	7161	3706,51196,9110,5579,8897,3710,9677,84812,23396,5295,3635,89869,8527,5330,9807,117283,253430,5728,27124,3613,3612,1606,160851,3631,23236,5291,5582,801,54928,8503,3636,5296,64768,9162,8898,23262,5286,64419,5333,5332,3705,5578,51763,51447,79837,3707,9107,80271,55529,8394,51806,5305,5288,805,55361,3709,810,8395,5290,5298,163688,808,8526,5335,10423,8760,1608,8871,1607,5336,3628,5297,5331,1609,8525,200576,8396,91860,5293,55300,5287,3633,8821,1040,3708,9108,8867,5289	ITPKA,PLCE1,MTMR4,PRKCB,MTMR3,ITPR3,PPIP5K1,PLCD4,PIP5K1C,PIK3R1,INPP5D,PLCZ1,DGKD,PLCB2,IP6K1,IP6K3,IPMK,PTEN,INPP5J,IMPA2,IMPA1,DGKA,DGKH,INPP4A,PLCB1,PIK3CB,PRKCG,CALM1,BPNT2,PIK3R3,INPPL1,PIK3R2,IPPK,DGKI,MTMR2,PPIP5K2,PIK3C2A,MTMR14,PLCD1,PLCB4,ITPK1,PRKCA,INPP5K,IP6K2,PIP4K2C,ITPKB,MTMR6,ITPKC,PIP4P2,PIP5K1A,CALML5,PIP4K2A,PIK3C2G,CALM2,PI4K2A,ITPR2,CALML3,PIP5K1B,PIK3CA,PI4KB,CALML6,CALM3,DGKE,PLCG1,CDIPT,CDS2,DGKG,SYNJ2,DGKB,PLCG2,INPP1,PI4KA,PLCB3,DGKQ,DGKZ,PIKFYVE,PIP4K2B,CALML4,PIK3CD,PI4K2B,PIK3C2B,INPP5B,INPP4B,CDS1,ITPR1,MTMR7,SYNJ1,PIK3C3
ko04070	Phosphatidylinositol signaling system	0.255181191206369	-1.36578143239704	97	88	0.013968253968254	6300	7161	3709,805,55361,5288,5305,51806,8394,55529,80271,9107,3707,79837,51447,1608,8760,10423,5335,8526,163688,808,5298,5290,8395,810,91860,8396,200576,8525,1609,5297,5331,3628,5336,1607,8871,5289,8867,9108,3708,1040,8821,3633,5287,5293,55300,23396,84812,9677,8897,3710,5579,9110,51196,3706,3612,3613,27124,5728,253430,117283,9807,5330,8527,89869,3635,5295,5296,3636,8503,54928,801,5582,5291,23236,3631,160851,1606,51763,5578,3705,5332,5333,64419,5286,23262,8898,9162,64768	ITPR2,CALM2,PI4K2A,PIK3C2G,PIP4K2A,CALML5,PIP5K1A,PIP4P2,ITPKC,MTMR6,ITPKB,PIP4K2C,IP6K2,DGKG,CDS2,CDIPT,PLCG1,DGKE,CALML6,CALM3,PI4KB,PIK3CA,PIP5K1B,CALML3,CALML4,PIP4K2B,PIKFYVE,DGKZ,DGKQ,PI4KA,PLCB3,INPP1,PLCG2,DGKB,SYNJ2,PIK3C3,SYNJ1,MTMR7,ITPR1,CDS1,INPP4B,INPP5B,PIK3C2B,PIK3CD,PI4K2B,PIP5K1C,PLCD4,PPIP5K1,MTMR3,ITPR3,PRKCB,MTMR4,PLCE1,ITPKA,IMPA1,IMPA2,INPP5J,PTEN,IPMK,IP6K3,IP6K1,PLCB2,DGKD,PLCZ1,INPP5D,PIK3R1,PIK3R2,INPPL1,PIK3R3,BPNT2,CALM1,PRKCG,PIK3CB,PLCB1,INPP4A,DGKH,DGKA,INPP5K,PRKCA,ITPK1,PLCB4,PLCD1,MTMR14,PIK3C2A,PPIP5K2,MTMR2,DGKI,IPPK
ko00512	Mucin type O-glycan biosynthesis	0.261857045725172	-1.33995655113278	31	29	0.0046031746031746	6300	7161	63917,2591,11227,79623,11226,55568,442117,55808,79695,192134,114805,9245,57452,8693,2590,117248,51809,6482,56913,6483,9334,64409,168391,26290,51301,2650,374378,2589,50614	GALNT11,GALNT3,GALNT5,GALNT14,GALNT6,GALNT10,GALNTL6,ST6GALNAC1,GALNT12,B3GNT6,GALNT13,GCNT3,GALNT16,GALNT4,GALNT2,GALNT15,GALNT7,ST3GAL1,C1GALT1,ST3GAL2,B4GALT5,GALNT17,GALNTL5,GALNT8,GCNT4,GCNT1,GALNT18,GALNT1,GALNT9
ko00052	Galactose metabolism	0.261857045725172	-1.33995655113278	31	29	0.0046031746031746	6300	7161	5214,3101,2548,7360,5211,231,5236,2584,8972,8704,2592,3906,55276,2595,2538,3938,93432,3098,130589,2645,6476,2720,2582,80201,57818,2683,57016,3099,92579	PFKP,HK3,GAA,UGP2,PFKL,AKR1B1,PGM1,GALK1,MGAM,B4GALT2,GALT,LALBA,PGM2,GANC,G6PC1,LCT,MGAM2,HK1,GALM,GCK,SI,GLB1,GALE,HKDC1,G6PC2,B4GALT1,AKR1B10,HK2,G6PC3
hsa00052	Galactose metabolism	0.261857045725172	-1.33995655113278	31	29	0.0046031746031746	6300	7161	3099,92579,2683,57016,80201,57818,2582,2720,93432,3098,130589,2645,6476,2592,8704,3906,55276,3938,2595,2538,8972,2584,5211,7360,5236,231,2548,3101,5214	HK2,G6PC3,B4GALT1,AKR1B10,HKDC1,G6PC2,GALE,GLB1,MGAM2,HK1,GALM,GCK,SI,GALT,B4GALT2,LALBA,PGM2,LCT,GANC,G6PC1,MGAM,GALK1,PFKL,UGP2,PGM1,AKR1B1,GAA,HK3,PFKP
hsa00512	Mucin type O-glycan biosynthesis	0.261857045725172	-1.33995655113278	31	29	0.0046031746031746	6300	7161	57452,8693,9245,114805,192134,55568,442117,79695,55808,79623,11226,63917,2591,11227,2589,50614,51301,374378,2650,168391,64409,26290,9334,6482,6483,56913,117248,51809,2590	GALNT16,GALNT4,GCNT3,GALNT13,B3GNT6,GALNT10,GALNTL6,GALNT12,ST6GALNAC1,GALNT14,GALNT6,GALNT11,GALNT3,GALNT5,GALNT1,GALNT9,GCNT4,GALNT18,GCNT1,GALNTL5,GALNT17,GALNT8,B4GALT5,ST3GAL1,ST3GAL2,C1GALT1,GALNT15,GALNT7,GALNT2
M00688	MAPK (JNK) signaling	0.262238062252063	-1.33850255322966	21	20	0.00317460317460317	6300	7161	9064,9344,4214,6885,84451,4215,4296,51347,4293,57551,1326,5602,10746,5601,4216,5599,5609,6416,4294,4217	MAP3K6,TAOK2,MAP3K1,MAP3K7,MAP3K21,MAP3K3,MAP3K11,TAOK3,MAP3K9,TAOK1,MAP3K8,MAPK10,MAP3K2,MAPK9,MAP3K4,MAPK8,MAP2K7,MAP2K4,MAP3K10,MAP3K5
hsa_M00688	MAPK (JNK) signaling	0.262238062252063	-1.33850255322966	21	20	0.00317460317460317	6300	7161	4214,9064,9344,4296,6885,4215,84451,10746,5601,4216,5599,4293,51347,57551,1326,5602,6416,4294,4217,5609	MAP3K1,MAP3K6,TAOK2,MAP3K11,MAP3K7,MAP3K3,MAP3K21,MAP3K2,MAPK9,MAP3K4,MAPK8,MAP3K9,TAOK3,TAOK1,MAP3K8,MAPK10,MAP2K4,MAP3K10,MAP3K5,MAP2K7
hsa_M00681	Activin signaling	0.277520726862432	-1.28185965718876	10	10	0.00158730158730159	6300	7161	4088,3624,3626,93,92,4087,83729,91,4089,3625	SMAD3,INHBA,INHBC,ACVR2B,ACVR2A,SMAD2,INHBE,ACVR1B,SMAD4,INHBB
M00681	Activin signaling	0.277520726862432	-1.28185965718876	10	10	0.00158730158730159	6300	7161	3625,4089,4087,83729,91,92,3626,3624,4088,93	INHBB,SMAD4,SMAD2,INHBE,ACVR1B,ACVR2A,INHBC,INHBA,SMAD3,ACVR2B
ko05145	Toxoplasmosis	0.279267007675358	-1.27558693805179	113	102	0.0161904761904762	6300	7161	3118,3688,5594,22798,7043,7042,7124,836,10000,3588,5170,208,1147,6772,4793,4792,841,3458,3908,51135,3911,5595,54205,1234,596,10454,8651,3909,3113,3112,3459,3915,1432,7040,2771,4615,6300,330,4790,5601,3914,3587,3593,3592,207,3119,284217,3117,5606,3716,23118,5600,5608,4261,7189,3109,842,3912,3913,7132,3305,6885,146850,5294,345611,2770,7097,7099,3312,3655,3304,7297,3460,5599,5603,5602,10105,3918,3551,3910,23533,5970,23643,958,3127,112401,598,3108,3111,2773,3949,3586,3123,3122,3306,10319,240,6774,3717,329,3310,79444	HLA-DQA2,ITGB1,MAPK1,LAMB4,TGFB3,TGFB2,TNF,CASP3,AKT3,IL10RB,PDPK1,AKT2,CHUK,STAT1,NFKBIB,NFKBIA,CASP8,IFNG,LAMA2,IRAK4,LAMA5,MAPK3,CYCS,CCR5,BCL2,TAB1,SOCS1,LAMA3,HLA-DPA1,HLA-DOB,IFNGR1,LAMC1,MAPK14,TGFB1,GNAI2,MYD88,MAPK12,BIRC3,NFKB1,MAPK9,LAMB3,IL10RA,IL12B,IL12A,AKT1,HLA-DQB1,LAMA1,HLA-DQA1,MAP2K3,JAK1,TAB2,MAPK11,MAP2K6,CIITA,TRAF6,HLA-DMB,CASP9,LAMB1,LAMB2,TNFRSF1A,HSPA1L,MAP3K7,PIK3R6,PIK3CG,IRGM,GNAI1,TLR2,TLR4,HSPA8,ITGA6,HSPA1B,TYK2,IFNGR2,MAPK8,MAPK13,MAPK10,PPIF,LAMC2,IKBKB,LAMA4,PIK3R5,RELA,LY96,CD40,HLA-DRB5,BIRC8,BCL2L1,HLA-DMA,HLA-DOA,GNAI3,LDLR,IL10,HLA-DRB1,HLA-DRA,HSPA2,LAMC3,ALOX5,STAT3,JAK2,BIRC2,HSPA6,BIRC7
hsa05145	Toxoplasmosis	0.279267007675358	-1.27558693805179	113	102	0.0161904761904762	6300	7161	3127,958,23643,5970,23533,3551,3910,3918,10105,5603,5602,3460,5599,7297,79444,3310,3717,329,6774,240,10319,3306,3123,3586,3122,2773,3949,3111,3108,112401,598,146850,5294,345611,6885,3305,7132,3912,3913,842,3109,7189,4261,5608,5600,23118,3304,3655,3312,7099,7097,2770,330,4615,6300,7040,2771,1432,3459,3915,3113,3112,8651,3909,3716,5606,3117,284217,207,3119,3593,3592,3914,3587,4790,5601,6772,1147,208,5170,3588,836,10000,7124,7043,7042,22798,3688,5594,3118,10454,596,1234,54205,5595,3911,51135,3908,841,3458,4793,4792	HLA-DRB5,CD40,LY96,RELA,PIK3R5,IKBKB,LAMA4,LAMC2,PPIF,MAPK13,MAPK10,IFNGR2,MAPK8,TYK2,BIRC7,HSPA6,JAK2,BIRC2,STAT3,ALOX5,LAMC3,HSPA2,HLA-DRB1,IL10,HLA-DRA,GNAI3,LDLR,HLA-DOA,HLA-DMA,BIRC8,BCL2L1,PIK3R6,PIK3CG,IRGM,MAP3K7,HSPA1L,TNFRSF1A,LAMB1,LAMB2,CASP9,HLA-DMB,TRAF6,CIITA,MAP2K6,MAPK11,TAB2,HSPA1B,ITGA6,HSPA8,TLR4,TLR2,GNAI1,BIRC3,MYD88,MAPK12,TGFB1,GNAI2,MAPK14,IFNGR1,LAMC1,HLA-DPA1,HLA-DOB,SOCS1,LAMA3,JAK1,MAP2K3,HLA-DQA1,LAMA1,AKT1,HLA-DQB1,IL12B,IL12A,LAMB3,IL10RA,NFKB1,MAPK9,STAT1,CHUK,AKT2,PDPK1,IL10RB,CASP3,AKT3,TNF,TGFB3,TGFB2,LAMB4,ITGB1,MAPK1,HLA-DQA2,TAB1,BCL2,CCR5,CYCS,MAPK3,LAMA5,IRAK4,LAMA2,CASP8,IFNG,NFKBIB,NFKBIA
hsa00510	N-Glycan biosynthesis	0.28214009914984	-1.26535152591513	49	45	0.00714285714285714	6300	7161	29929,1650,57134,10905,7841,4248,4245,2530,144245,6184,152586,146664,25834,8703,4124,84920,6185,8818,23193,85365,79053,10195,3703,57171,79087,6480,4122,201595,54344,8704,79796,29880,84620,7991,4249,22845,199857,2683,4121,1603,56052,8813,4247,11320,11282	ALG6,DDOST,MAN1C1,MAN1A2,MOGS,MGAT3,MGAT1,FUT8,ALG10B,RPN1,MGAT4D,MGAT5B,MGAT4C,B4GALT3,MAN2A1,ALG10,RPN2,DPM2,GANAB,ALG2,ALG8,ALG3,STT3A,DOLPP1,ALG12,ST6GAL1,MAN2A2,STT3B,DPM3,B4GALT2,ALG9,ALG5,ST6GAL2,TUSC3,MGAT5,DOLK,ALG14,B4GALT1,MAN1A1,DAD1,ALG1,DPM1,MGAT2,MGAT4A,MGAT4B
ko00510	N-Glycan biosynthesis	0.28214009914984	-1.26535152591513	49	45	0.00714285714285714	6300	7161	8703,152586,146664,25834,4124,23193,84920,6185,8818,79053,10195,85365,3703,57171,29929,1650,4248,4245,57134,7841,10905,144245,2530,6184,4249,7991,4121,2683,22845,199857,8813,1603,56052,11282,4247,11320,6480,79087,4122,54344,8704,201595,29880,79796,84620	B4GALT3,MGAT4D,MGAT5B,MGAT4C,MAN2A1,GANAB,ALG10,RPN2,DPM2,ALG8,ALG3,ALG2,STT3A,DOLPP1,ALG6,DDOST,MGAT3,MGAT1,MAN1C1,MOGS,MAN1A2,ALG10B,FUT8,RPN1,MGAT5,TUSC3,MAN1A1,B4GALT1,DOLK,ALG14,DPM1,DAD1,ALG1,MGAT4B,MGAT2,MGAT4A,ST6GAL1,ALG12,MAN2A2,DPM3,B4GALT2,STT3B,ALG5,ALG9,ST6GAL2
hsa05030	Cocaine addiction	0.28214009914984	-1.26535152591513	49	45	0.00714285714285714	6300	7161	64764,84152,1020,6531,8787,8851,2905,116443,3725,1742,1644,2770,2778,6570,116444,5566,2891,2912,2354,2913,1385,90993,1388,5567,2904,148327,2771,84699,1386,6571,10488,5568,2903,5970,1813,5173,1812,111,9586,2773,2906,4790,7054,468,627	CREB3L2,PPP1R1B,CDK5,SLC6A3,RGS9,CDK5R1,GRIN2C,GRIN3A,JUN,DLG4,DDC,GNAI1,GNAS,SLC18A1,GRIN3B,PRKACA,GRIA2,GRM2,FOSB,GRM3,CREB1,CREB3L1,ATF6B,PRKACB,GRIN2B,CREB3L4,GNAI2,CREB3L3,ATF2,SLC18A2,CREB3,PRKACG,GRIN2A,RELA,DRD2,PDYN,DRD1,ADCY5,CREB5,GNAI3,GRIN2D,NFKB1,TH,ATF4,BDNF
ko05030	Cocaine addiction	0.28214009914984	-1.26535152591513	49	45	0.00714285714285714	6300	7161	10488,5568,1386,6571,84699,2771,1813,5173,1812,2903,5970,4790,2906,9586,2773,111,627,468,7054,8787,84152,1020,6531,64764,2905,116443,8851,6570,1742,3725,2770,2778,1644,5567,2904,148327,90993,1385,1388,116444,2891,5566,2912,2913,2354	CREB3,PRKACG,ATF2,SLC18A2,CREB3L3,GNAI2,DRD2,PDYN,DRD1,GRIN2A,RELA,NFKB1,GRIN2D,CREB5,GNAI3,ADCY5,BDNF,ATF4,TH,RGS9,PPP1R1B,CDK5,SLC6A3,CREB3L2,GRIN2C,GRIN3A,CDK5R1,SLC18A1,DLG4,JUN,GNAI1,GNAS,DDC,PRKACB,GRIN2B,CREB3L4,CREB3L1,CREB1,ATF6B,GRIN3B,GRIA2,PRKACA,GRM2,GRM3,FOSB
hsa_M00354	Spliceosome, U4/U6.U5 tri-snRNP	0.282821372460425	-1.26293977334423	30	28	0.00444444444444444	6300	7161	6633,6635,9410,25804,23020,10465,9343,27258,57819,10421,9128,10713,9092,23658,11017,11157,6628,9129,26121,6637,4809,10907,51691,6636,9416,51690,10594,24148	SNRPD2,SNRPE,SNRNP40,LSM4,SNRNP200,PPIH,EFTUD2,LSM3,LSM2,CD2BP2,PRPF4,USP39,SART1,LSM5,SNRNP27,LSM6,SNRPB,PRPF3,PRPF31,SNRPG,SNU13,TXNL4A,LSM8,SNRPF,DDX23,LSM7,PRPF8,PRPF6
M00354	Spliceosome, U4/U6.U5 tri-snRNP	0.282821372460425	-1.26293977334423	30	28	0.00444444444444444	6300	7161	6637,4809,26121,9129,6628,24148,10594,6636,51690,9416,10907,51691,23658,9092,10713,11157,11017,9128,9410,6635,6633,10421,57819,10465,9343,23020,27258,25804	SNRPG,SNU13,PRPF31,PRPF3,SNRPB,PRPF6,PRPF8,SNRPF,LSM7,DDX23,TXNL4A,LSM8,LSM5,SART1,USP39,LSM6,SNRNP27,PRPF4,SNRNP40,SNRPE,SNRPD2,CD2BP2,LSM2,PPIH,EFTUD2,SNRNP200,LSM3,LSM4
ko00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.287618751996074	-1.24611945360545	20	19	0.00301587301587302	6300	7161	22856,55454,166012,54480,9469,79586,26229,11285,64131,51363,29940,50515,113189,126792,64132,10090,337876,55501,55790	CHSY1,CSGALNACT2,CHST13,CHPF2,CHST3,CHPF,B3GAT3,B4GALT7,XYLT1,CHST15,DSE,CHST11,CHST14,B3GALT6,XYLT2,UST,CHSY3,CHST12,CSGALNACT1
hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.287618751996074	-1.24611945360545	20	19	0.00301587301587302	6300	7161	51363,26229,79586,11285,64131,9469,54480,166012,55454,22856,55790,337876,55501,10090,64132,126792,113189,29940,50515	CHST15,B3GAT3,CHPF,B4GALT7,XYLT1,CHST3,CHPF2,CHST13,CSGALNACT2,CHSY1,CSGALNACT1,CHSY3,CHST12,UST,XYLT2,B3GALT6,CHST14,DSE,CHST11
ko00010	Glycolysis / Gluconeogenesis	0.289541747486419	-1.23945578688584	67	61	0.00968253968253968	6300	7161	92483,226,219,57818,92579,5313,669,126,3099,222,1737,9562,5211,3945,3101,3948,5223,131,221,8789,26330,218,127,84532,2645,2538,5105,2026,160287,5224,128,217,2597,80201,2027,5315,220,130,3939,1738,5162,5232,2203,10327,7167,501,5236,2821,55902,223,229,5214,124,5161,125,2023,83440,3098,224,130589,55276	LDHAL6B,ALDOA,ALDH1B1,G6PC2,G6PC3,PKLR,BPGM,ADH1C,HK2,ALDH3B2,DLAT,MINPP1,PFKL,LDHB,HK3,LDHC,PGAM1,ADH7,ALDH3B1,FBP2,GAPDHS,ALDH3A1,ADH4,ACSS1,GCK,G6PC1,PCK1,ENO2,LDHAL6A,PGAM2,ADH5,ALDH2,GAPDH,HKDC1,ENO3,PKM,ALDH1A3,ADH6,LDHA,DLD,PDHB,PGK2,FBP1,AKR1A1,TPI1,ALDH7A1,PGM1,GPI,ACSS2,ALDH9A1,ALDOB,PFKP,ADH1A,PDHA2,ADH1B,ENO1,ADPGK,HK1,ALDH3A2,GALM,PGM2
hsa00010	Glycolysis / Gluconeogenesis	0.289541747486419	-1.23945578688584	67	61	0.00968253968253968	6300	7161	5211,9562,1737,5223,3948,3101,3945,26330,8789,221,131,2538,84532,2645,218,127,226,92483,57818,219,3099,126,669,5313,92579,222,2821,501,5236,7167,10327,124,5214,229,223,55902,125,5161,55276,130589,83440,224,3098,2023,5224,160287,2026,5105,2027,80201,2597,217,128,5162,1738,130,3939,5315,220,2203,5232	PFKL,MINPP1,DLAT,PGAM1,LDHC,HK3,LDHB,GAPDHS,FBP2,ALDH3B1,ADH7,G6PC1,ACSS1,GCK,ALDH3A1,ADH4,ALDOA,LDHAL6B,G6PC2,ALDH1B1,HK2,ADH1C,BPGM,PKLR,G6PC3,ALDH3B2,GPI,ALDH7A1,PGM1,TPI1,AKR1A1,ADH1A,PFKP,ALDOB,ALDH9A1,ACSS2,ADH1B,PDHA2,PGM2,GALM,ADPGK,ALDH3A2,HK1,ENO1,PGAM2,LDHAL6A,ENO2,PCK1,ENO3,HKDC1,GAPDH,ALDH2,ADH5,PDHB,DLD,ADH6,LDHA,PKM,ALDH1A3,FBP1,PGK2
ko04064	NF-kappa B signaling pathway	0.291898069397501	-1.23135061506137	94	85	0.0134920634920635	6300	7161	6363,29760,23085,10892,3551,8915,5328,148022,8740,3932,2920,4615,5970,330,472,23643,5336,958,3383,4790,84433,388372,7185,7188,598,4055,4050,8717,3553,10673,1459,23586,353376,4067,1457,115650,329,929,29775,51588,6366,6351,5579,23118,8837,5743,4791,3554,8792,7189,114609,3929,283106,7124,7132,7706,6357,597,7187,8600,4049,3576,5588,1147,6885,6850,9020,7128,5335,27040,79092,4792,4616,51135,55367,7535,6387,7099,8737,142,7412,596,5971,10454,7329	CCL19,BLNK,ERC1,MALT1,IKBKB,BCL10,PLAU,TICAM1,TNFSF14,LCK,CXCL2,MYD88,RELA,BIRC3,ATM,LY96,PLCG2,CD40,ICAM1,NFKB1,CARD11,CCL4L1,TRAF1,TRAF5,BCL2L1,LTBR,LTB,TRADD,IL1B,TNFSF13B,CSNK2A2,RIGI,TICAM2,LYN,CSNK2A1,TNFRSF13C,BIRC2,CD14,CARD10,PIAS4,CCL21,CCL4,PRKCB,TAB2,CFLAR,PTGS2,NFKB2,IL1R1,TNFRSF11A,TRAF6,TIRAP,LBP,CSNK2A3,TNF,TNFRSF1A,TRIM25,CCL13,BCL2A1,TRAF3,TNFSF11,LTA,CXCL8,PRKCQ,CHUK,MAP3K7,SYK,MAP3K14,TNFAIP3,PLCG1,LAT,CARD14,NFKBIA,GADD45B,IRAK4,PIDD1,ZAP70,CXCL12,TLR4,RIPK1,PARP1,VCAM1,BCL2,RELB,TAB1,UBE2I
hsa04064	NF-kappa B signaling pathway	0.291898069397501	-1.23135061506137	94	85	0.0134920634920635	6300	7161	4615,2920,3932,8740,148022,5328,8915,3383,5336,958,23643,5970,330,472,23085,10892,29760,6363,3551,929,29775,1457,4067,329,115650,353376,6366,51588,4055,4050,388372,7185,7188,598,84433,4790,3553,10673,23586,1459,8717,8600,4049,7187,6357,597,7132,7706,1147,6885,3576,5588,3554,8792,4791,23118,5579,5743,8837,6351,7124,3929,283106,7189,114609,142,8737,7099,7329,10454,5971,7412,596,27040,5335,79092,4792,7128,6850,9020,6387,7535,55367,51135,4616	MYD88,CXCL2,LCK,TNFSF14,TICAM1,PLAU,BCL10,ICAM1,PLCG2,CD40,LY96,RELA,BIRC3,ATM,ERC1,MALT1,BLNK,CCL19,IKBKB,CD14,CARD10,CSNK2A1,LYN,BIRC2,TNFRSF13C,TICAM2,CCL21,PIAS4,LTBR,LTB,CCL4L1,TRAF1,TRAF5,BCL2L1,CARD11,NFKB1,IL1B,TNFSF13B,RIGI,CSNK2A2,TRADD,TNFSF11,LTA,TRAF3,CCL13,BCL2A1,TNFRSF1A,TRIM25,CHUK,MAP3K7,CXCL8,PRKCQ,IL1R1,TNFRSF11A,NFKB2,TAB2,PRKCB,PTGS2,CFLAR,CCL4,TNF,LBP,CSNK2A3,TRAF6,TIRAP,PARP1,RIPK1,TLR4,UBE2I,TAB1,RELB,VCAM1,BCL2,LAT,PLCG1,CARD14,NFKBIA,TNFAIP3,SYK,MAP3K14,CXCL12,ZAP70,PIDD1,IRAK4,GADD45B
hsa05010	Alzheimer's disease	0.292546809751304	-1.2291305917764	165	148	0.0234920634920635	6300	7161	805,522,7124,1327,3709,4698,3416,25825,1350,5594,83464,5534,489,779,2905,513,8851,51806,1345,4702,515,10313,4728,4720,5663,1329,836,775,4714,509,6392,5595,55967,4311,5535,488,4707,518,126328,841,4715,810,54205,6389,808,163688,4709,22926,2904,57142,91860,9451,6622,5331,4716,487,4700,4711,4708,517,348,6263,4722,4723,2776,498,374291,3553,23621,4035,823,6390,10476,100506742,1346,355,1339,3708,341947,2906,10975,4697,4729,23385,1337,514,6391,4695,842,3710,8883,322,4731,4842,1020,9377,1340,4725,7132,4137,7385,5530,5330,4706,4710,4718,7384,4724,2081,351,102,4717,840,6868,8772,9167,2903,4023,4705,801,4719,317,23236,1347,7386,5533,539,5532,170712,4726,1351,51079,2597,5332,2932,56901,4712,5664,506,824,4696,7381,51107,776,4704,440567,516,29796	CALM2,ATP5PF,TNF,COX4I1,ITPR2,NDUFA5,IDE,BACE2,COX7C,MAPK1,APH1B,PPP3R1,ATP2A3,CACNA1S,GRIN2C,ATP5F1D,CDK5R1,CALML5,COX6C,NDUFA8,ATP5PB,RTN3,NDUFS8,NDUFS2,PSEN1,COX5B,CASP3,CACNA1C,NDUFB8,ATP5F1C,SDHD,MAPK3,NDUFA12,MME,PPP3R2,ATP2A2,NDUFB1,ATP5MC3,NDUFA11,CASP8,NDUFB9,CALML3,CYCS,SDHA,CALM3,CALML6,NDUFB3,ATF6,GRIN2B,RTN4,CALML4,EIF2AK3,SNCA,PLCB3,NDUFB10,ATP2A1,NDUFA6,NDUFB5,NDUFB2,ATP5MC2,APOE,RYR3,NDUFS3,NDUFV1,GNAQ,ATP5F1A,NDUFS7,IL1B,BACE1,LRP1,CAPN1,SDHB,ATP5PD,CASP12,COX7A1,FAS,COX6A2,ITPR1,COX8C,GRIN2D,UQCR11,NDUFA4,NDUFV2,NCSTN,COX6A1,ATP5F1E,SDHC,NDUFA2,CASP9,ITPR3,NAE1,APBB1,NDUFV3,NOS1,CDK5,COX5A,COX6B1,NDUFS5,TNFRSF1A,MAPT,UQCRC2,PPP3CA,PLCB2,NDUFAB1,NDUFB4,NDUFC2,UQCRC1,NDUFS4,ERN1,APP,ADAM10,NDUFC1,CASP7,ADAM17,FADD,COX7A2L,GRIN2A,LPL,NDUFA10,CALM1,NDUFS1,APAF1,PLCB1,COX7A2,UQCRFS1,PPP3CC,ATP5PO,PPP3CB,COX7B2,NDUFS6,COX8A,NDUFA13,GAPDH,PLCB4,GSK3B,NDUFA4L2,NDUFB6,PSEN2,ATP5F1B,CAPN2,NDUFA3,UQCRB,APH1A,CACNA1D,NDUFA9,UQCRHL,ATP5MC1,UQCR10
ko05010	Alzheimer's disease	0.292546809751304	-1.2291305917764	165	148	0.0234920634920635	6300	7161	4723,4722,348,6263,2776,498,487,517,4708,4700,4711,6622,9451,4716,5331,57142,91860,23385,4697,4729,1337,1339,1346,355,10975,2906,341947,3708,6390,823,4035,23621,3553,374291,100506742,10476,836,1329,4720,4728,10313,5663,515,509,4714,775,2905,489,779,4702,1345,8851,51806,513,25825,5534,83464,5594,1350,522,805,3416,4698,3709,1327,7124,6389,54205,810,2904,22926,4709,808,163688,4715,126328,841,4707,488,5535,6392,5595,55967,4311,518,317,4719,23236,4023,2903,801,4705,840,9167,8772,6868,4717,102,51107,776,4704,7381,4696,516,29796,440567,4712,824,506,5664,5332,51079,2597,1351,56901,2932,5532,539,5533,7386,1347,4726,170712,7132,4725,7385,4137,9377,1340,3710,1020,4842,4731,322,8883,514,842,4695,6391,351,2081,7384,4718,4710,4724,4706,5330,5530	NDUFV1,NDUFS3,APOE,RYR3,GNAQ,ATP5F1A,ATP2A1,ATP5MC2,NDUFB2,NDUFA6,NDUFB5,SNCA,EIF2AK3,NDUFB10,PLCB3,RTN4,CALML4,NCSTN,NDUFA4,NDUFV2,COX6A1,COX6A2,COX7A1,FAS,UQCR11,GRIN2D,COX8C,ITPR1,SDHB,CAPN1,LRP1,BACE1,IL1B,NDUFS7,CASP12,ATP5PD,CASP3,COX5B,NDUFS2,NDUFS8,RTN3,PSEN1,ATP5PB,ATP5F1C,NDUFB8,CACNA1C,GRIN2C,ATP2A3,CACNA1S,NDUFA8,COX6C,CDK5R1,CALML5,ATP5F1D,BACE2,PPP3R1,APH1B,MAPK1,COX7C,ATP5PF,CALM2,IDE,NDUFA5,ITPR2,COX4I1,TNF,SDHA,CYCS,CALML3,GRIN2B,ATF6,NDUFB3,CALM3,CALML6,NDUFB9,NDUFA11,CASP8,NDUFB1,ATP2A2,PPP3R2,SDHD,MAPK3,NDUFA12,MME,ATP5MC3,APAF1,NDUFS1,PLCB1,LPL,GRIN2A,CALM1,NDUFA10,CASP7,COX7A2L,FADD,ADAM17,NDUFC1,ADAM10,APH1A,CACNA1D,NDUFA9,UQCRB,NDUFA3,ATP5MC1,UQCR10,UQCRHL,NDUFB6,CAPN2,ATP5F1B,PSEN2,PLCB4,NDUFA13,GAPDH,COX8A,NDUFA4L2,GSK3B,PPP3CB,ATP5PO,PPP3CC,UQCRFS1,COX7A2,NDUFS6,COX7B2,TNFRSF1A,NDUFS5,UQCRC2,MAPT,COX5A,COX6B1,ITPR3,CDK5,NOS1,NDUFV3,APBB1,NAE1,ATP5F1E,CASP9,NDUFA2,SDHC,APP,ERN1,UQCRC1,NDUFC2,NDUFB4,NDUFS4,NDUFAB1,PLCB2,PPP3CA
ko00520	Amino sugar and nucleotide sugar metabolism	0.29961658728859	-1.20525166408997	48	44	0.00698412698412698	6300	7161	5372,5373,80201,2582,1118,7358,132789,51706,80896,64841,55577,197258,5238,6675,7264,10007,3099,1727,4351,606495,3074,80146,3101,9945,29925,54187,2762,8790,2673,140838,2584,2821,51700,27159,5236,7360,51167,2645,3098,10020,2592,55907,55276,29926	PMM1,PMM2,HKDC1,GALE,CHIT1,UGDH,GNPDA2,CYB5R1,NPL,GNPNAT1,NAGK,FCSK,PGM3,UAP1,GFUS,GNPDA1,HK2,CYB5R3,MPI,CYB5RL,HEXB,UXS1,HK3,GFPT2,GMPPB,NANS,GMDS,FPGT,GFPT1,NANP,GALK1,GPI,CYB5R2,CHIA,PGM1,UGP2,CYB5R4,GCK,HK1,GNE,GALT,CMAS,PGM2,GMPPA
ko01212	Fatty acid metabolism	0.29961658728859	-1.20525166408997	48	44	0.00698412698412698	6300	7161	3030,3992,6319,2180,54898,60481,51,30,2194,201562,37,51495,31,9415,23305,9524,38,51144,51102,1374,8310,3032,3033,51703,1962,79966,9200,39,23205,79071,35,10449,81616,1376,126129,401494,33,27349,34,2181,55825,36,5538,54995	HADHA,FADS1,SCD,ACSL1,ELOVL2,ELOVL5,ACOX1,ACAA1,FASN,HACD2,ACADVL,HACD3,ACACA,FADS2,ACSL6,TECR,ACAT1,HSD17B12,MECR,CPT1A,ACOX3,HADHB,HADH,ACSL5,EHHADH,SCD5,HACD1,ACAT2,ACSBG1,ELOVL6,ACADS,ACAA2,ACSBG2,CPT2,CPT1C,HACD4,ACADL,MCAT,ACADM,ACSL3,PECR,ACADSB,PPT1,OXSM
hsa00280	Valine, leucine and isoleucine degradation	0.29961658728859	-1.20525166408997	48	44	0.00698412698412698	6300	7161	549,587,5019,259307,11112,26275,5096,3157,219,36,217,38,1738,34,316,84693,64064,35,10449,4594,501,4329,1629,27034,65985,594,586,64902,223,30,39,3712,5095,197322,1962,18,3155,54511,3030,224,3033,593,56922,3032	AUH,BCAT2,OXCT1,IL4I1,HIBADH,HIBCH,PCCB,HMGCS1,ALDH1B1,ACADSB,ALDH2,ACAT1,DLD,ACADM,AOX1,MCEE,OXCT2,ACADS,ACAA2,MMUT,ALDH7A1,ALDH6A1,DBT,ACAD8,AACS,BCKDHB,BCAT1,AGXT2,ALDH9A1,ACAA1,ACAT2,IVD,PCCA,ACSF3,EHHADH,ABAT,HMGCL,HMGCLL1,HADHA,ALDH3A2,HADH,BCKDHA,MCCC1,HADHB
hsa00520	Amino sugar and nucleotide sugar metabolism	0.29961658728859	-1.20525166408997	48	44	0.00698412698412698	6300	7161	2584,51167,3101,9945,54187,29925,2673,29926,2645,7358,64841,55577,197258,5372,5373,1118,3099,606495,3074,5238,6675,10007,140838,2821,27159,51700,5236,7360,80146,2762,8790,3098,10020,55907,2592,55276,132789,80896,51706,80201,2582,1727,4351,7264	GALK1,CYB5R4,HK3,GFPT2,NANS,GMPPB,GFPT1,GMPPA,GCK,UGDH,GNPNAT1,NAGK,FCSK,PMM1,PMM2,CHIT1,HK2,CYB5RL,HEXB,PGM3,UAP1,GNPDA1,NANP,GPI,CHIA,CYB5R2,PGM1,UGP2,UXS1,GMDS,FPGT,HK1,GNE,CMAS,GALT,PGM2,GNPDA2,NPL,CYB5R1,HKDC1,GALE,CYB5R3,MPI,GFUS
hsa01212	Fatty acid metabolism	0.29961658728859	-1.20525166408997	48	44	0.00698412698412698	6300	7161	9415,23305,9524,38,51144,51102,1374,8310,3030,3992,6319,2180,60481,54898,51,2194,201562,30,37,51495,31,10449,35,81616,1376,33,401494,126129,27349,34,55825,2181,36,54995,5538,3033,3032,51703,79966,1962,9200,39,79071,23205	FADS2,ACSL6,TECR,ACAT1,HSD17B12,MECR,CPT1A,ACOX3,HADHA,FADS1,SCD,ACSL1,ELOVL5,ELOVL2,ACOX1,FASN,HACD2,ACAA1,ACADVL,HACD3,ACACA,ACAA2,ACADS,ACSBG2,CPT2,ACADL,HACD4,CPT1C,MCAT,ACADM,PECR,ACSL3,ACADSB,OXSM,PPT1,HADH,HADHB,ACSL5,SCD5,EHHADH,HACD1,ACAT2,ELOVL6,ACSBG1
ko00280	Valine, leucine and isoleucine degradation	0.29961658728859	-1.20525166408997	48	44	0.00698412698412698	6300	7161	594,65985,30,223,586,64902,3712,39,4329,501,1629,27034,3155,224,54511,3030,56922,3032,593,3033,197322,5095,18,1962,26275,3157,5096,36,217,219,587,549,5019,259307,11112,84693,64064,4594,10449,35,34,1738,38,316	BCKDHB,AACS,ACAA1,ALDH9A1,BCAT1,AGXT2,IVD,ACAT2,ALDH6A1,ALDH7A1,DBT,ACAD8,HMGCL,ALDH3A2,HMGCLL1,HADHA,MCCC1,HADHB,BCKDHA,HADH,ACSF3,PCCA,ABAT,EHHADH,HIBCH,HMGCS1,PCCB,ACADSB,ALDH2,ALDH1B1,BCAT2,AUH,OXCT1,IL4I1,HIBADH,MCEE,OXCT2,MMUT,ACAA2,ACADS,ACADM,DLD,ACAT1,AOX1
ko04114	Oocyte meiosis	0.301314116735689	-1.19960198118642	120	108	0.0171428571428571	6300	7161	5532,729597,5533,29945,816,51529,9700,107,5515,898,9134,7531,5499,4342,112,10744,23291,5528,387778,10971,8697,26271,801,995,9126,9978,5530,5527,983,245711,115,89869,5566,109,5529,113,5516,108,3710,7534,51433,196883,10393,8945,5500,7532,7533,22849,111,64682,9088,6196,388333,3708,9232,5518,5501,441272,285955,91860,817,9748,80315,5241,5347,100310812,5568,132864,1017,4085,5525,6500,51434,6300,286151,5535,5595,5604,114,5526,818,810,5567,163688,808,7529,996,3630,805,3709,27127,151648,3479,815,5534,5594,991,9133,891,3480,699,5519,64506,6195,10459,6790,51806,8454	PPP3CB,SPDYE6,PPP3CC,ANAPC4,CAMK2B,ANAPC11,ESPL1,ADCY1,PPP2CA,CCNE1,CCNE2,YWHAE,PPP1CA,MOS,ADCY6,PTTG2,FBXW11,PPP2R5D,SPDYC,YWHAQ,CDC23,FBXO5,CALM1,CDC25C,SMC3,RBX1,PPP3CA,PPP2R5C,CDK1,SPDYA,ADCY9,PLCZ1,PRKACA,ADCY3,PPP2R5E,ADCY7,PPP2CB,ADCY2,ITPR3,YWHAZ,ANAPC5,ADCY4,ANAPC10,BTRC,PPP1CB,YWHAG,YWHAH,CPEB3,ADCY5,ANAPC1,PKMYT1,RPS6KA2,SPDYE4,ITPR1,PTTG1,PPP2R1A,PPP1CC,SPDYE3,SPDYE1,CALML4,CAMK2D,SLK,CPEB4,PGR,PLK1,SPDYE2B,PRKACG,CPEB2,CDK2,MAD2L1,PPP2R5A,SKP1,ANAPC7,MAPK12,FBXO43,PPP3R2,MAPK3,MAP2K1,ADCY8,PPP2R5B,CAMK2G,CALML3,PRKACB,CALML6,CALM3,YWHAB,CDC27,INS,CALM2,ITPR2,SMC1B,SGO1,IGF1,CAMK2A,PPP3R1,MAPK1,CDC20,CCNB2,CCNB1,IGF1R,BUB1,PPP2R1B,CPEB1,RPS6KA1,MAD2L2,AURKA,CALML5,CUL1
hsa04114	Oocyte meiosis	0.301314116735689	-1.19960198118642	120	108	0.0171428571428571	6300	7161	9700,816,51529,5532,5533,729597,29945,5515,898,9134,107,4342,112,10744,7531,5499,995,9126,9978,387778,5528,23291,801,26271,10971,8697,983,245711,5530,5527,5529,113,89869,115,109,5566,51433,3710,7534,196883,108,5516,5500,8945,10393,6196,9088,388333,3708,111,64682,7532,7533,22849,5501,5518,441272,9232,100310812,5568,5241,5347,285955,817,9748,80315,91860,6300,5525,4085,1017,132864,51434,6500,114,5526,286151,5535,5604,5595,810,996,3630,808,5567,163688,7529,818,815,3479,151648,5534,5594,991,805,27127,3709,8454,699,3480,64506,5519,891,9133,6790,10459,51806,6195	ESPL1,CAMK2B,ANAPC11,PPP3CB,PPP3CC,SPDYE6,ANAPC4,PPP2CA,CCNE1,CCNE2,ADCY1,MOS,ADCY6,PTTG2,YWHAE,PPP1CA,CDC25C,SMC3,RBX1,SPDYC,PPP2R5D,FBXW11,CALM1,FBXO5,YWHAQ,CDC23,CDK1,SPDYA,PPP3CA,PPP2R5C,PPP2R5E,ADCY7,PLCZ1,ADCY9,ADCY3,PRKACA,ANAPC5,ITPR3,YWHAZ,ADCY4,ADCY2,PPP2CB,PPP1CB,BTRC,ANAPC10,RPS6KA2,PKMYT1,SPDYE4,ITPR1,ADCY5,ANAPC1,YWHAG,YWHAH,CPEB3,PPP1CC,PPP2R1A,SPDYE3,PTTG1,SPDYE2B,PRKACG,PGR,PLK1,SPDYE1,CAMK2D,SLK,CPEB4,CALML4,MAPK12,PPP2R5A,MAD2L1,CDK2,CPEB2,ANAPC7,SKP1,ADCY8,PPP2R5B,FBXO43,PPP3R2,MAP2K1,MAPK3,CALML3,CDC27,INS,CALM3,PRKACB,CALML6,YWHAB,CAMK2G,CAMK2A,IGF1,SGO1,PPP3R1,MAPK1,CDC20,CALM2,SMC1B,ITPR2,CUL1,BUB1,IGF1R,CPEB1,PPP2R1B,CCNB1,CCNB2,AURKA,MAD2L2,CALML5,RPS6KA1
hsa_M00359	Aminoacyl-tRNA biosynthesis, eukaryotes	0.313538970109559	-1.15983162006502	38	35	0.00555555555555556	6300	7161	25973,79587,7453,2058,23438,7407,2193,51067,2617,5917,10056,6301,57505,833,4677,16,54938,5859,51520,57176,79731,1615,57038,55699,80222,4141,23395,8565,3376,10352,10667,124454,3735,92935,6897	PARS2,CARS2,WARS1,EPRS1,HARS2,VARS1,FARSA,YARS2,GARS1,RARS1,FARSB,SARS1,AARS2,CARS1,NARS1,AARS1,SARS2,QARS1,LARS1,VARS2,NARS2,DARS1,RARS2,IARS2,TARS2,MARS1,LARS2,YARS1,IARS1,WARS2,FARS2,EARS2,KARS1,MARS2,TARS1
M00359	Aminoacyl-tRNA biosynthesis, eukaryotes	0.313538970109559	-1.15983162006502	38	35	0.00555555555555556	6300	7161	57038,1615,16,54938,5859,51520,57176,79731,10352,10667,124454,3735,92935,6897,55699,80222,4141,23395,3376,8565,79587,7453,2058,7407,23438,2193,51067,2617,25973,57505,4677,833,5917,10056,6301	RARS2,DARS1,AARS1,SARS2,QARS1,LARS1,VARS2,NARS2,WARS2,FARS2,EARS2,KARS1,MARS2,TARS1,IARS2,TARS2,MARS1,LARS2,IARS1,YARS1,CARS2,WARS1,EPRS1,VARS1,HARS2,FARSA,YARS2,GARS1,PARS2,AARS2,NARS1,CARS1,RARS1,FARSB,SARS1
hsa_M00694	cGMP signaling	0.315502819663033	-1.1535876599155	9	9	0.00142857142857143	6300	7161	5592,1259,2977,4882,5138,1258,4881,2983,2982	PRKG1,CNGA1,GUCY1A2,NPR2,PDE2A,CNGB1,NPR1,GUCY1B1,GUCY1A1
M00694	cGMP signaling	0.315502819663033	-1.1535876599155	9	9	0.00142857142857143	6300	7161	2982,2983,4881,1258,5138,4882,2977,1259,5592	GUCY1A1,GUCY1B1,NPR1,CNGB1,PDE2A,NPR2,GUCY1A2,CNGA1,PRKG1
ko00600	Sphingolipid metabolism	0.317828361593018	-1.14624378533406	47	43	0.00682539682539683	6300	7161	56624,7368,57704,9331,259230,125981,253782,8877,2581,7357,8879,29956,10558,9514,8560,4758,91012,10825,55627,55304,81537,79603,64781,2531,427,9517,340485,56848,339221,2629,2720,8611,204219,130367,6610,55512,6609,123099,166929,10715,55331,8612,8613	ASAH2,UGT8,GBA2,B4GALT6,SGMS1,ACER1,CERS6,SPHK1,GALC,UGCG,SGPL1,CERS2,SPTLC1,GAL3ST1,DEGS1,NEU1,CERS5,NEU3,SMPD4,SPTLC3,SGPP1,CERS4,CERK,KDSR,ASAH1,SPTLC2,ACER2,SPHK2,ENPP7,GBA1,GLB1,PLPP1,CERS3,SGPP2,SMPD2,SMPD3,SMPD1,DEGS2,SGMS2,CERS1,ACER3,PLPP2,PLPP3
ko04672	Intestinal immune network for IgA production	0.317828361593018	-1.14624378533406	47	43	0.00682539682539683	6300	7161	9020,3108,3111,4055,56477,3569,6370,3119,3558,8174,10673,3122,3586,3123,6387,3601,7852,608,5284,115650,3695,8741,3117,3567,941,23308,3118,3112,3113,23495,10803,3676,3600,29851,3109,7040,3565,942,2826,958,57379,3127,940	MAP3K14,HLA-DMA,HLA-DOA,LTBR,CCL28,IL6,CCL25,HLA-DQB1,IL2,MADCAM1,TNFSF13B,HLA-DRA,IL10,HLA-DRB1,CXCL12,IL15RA,CXCR4,TNFRSF17,PIGR,TNFRSF13C,ITGB7,TNFSF13,HLA-DQA1,IL5,CD80,ICOSLG,HLA-DQA2,HLA-DOB,HLA-DPA1,TNFRSF13B,CCR9,ITGA4,IL15,ICOS,HLA-DMB,TGFB1,IL4,CD86,CCR10,CD40,AICDA,HLA-DRB5,CD28
hsa00600	Sphingolipid metabolism	0.317828361593018	-1.14624378533406	47	43	0.00682539682539683	6300	7161	9514,8560,8611,2720,10558,8879,2629,29956,7357,339221,2581,8877,125981,253782,56848,340485,57704,9517,259230,9331,427,56624,7368,8612,8613,64781,2531,79603,81537,10715,55304,55331,166929,55627,10825,123099,6609,91012,55512,6610,4758,130367,204219	GAL3ST1,DEGS1,PLPP1,GLB1,SPTLC1,SGPL1,GBA1,CERS2,UGCG,ENPP7,GALC,SPHK1,ACER1,CERS6,SPHK2,ACER2,GBA2,SPTLC2,SGMS1,B4GALT6,ASAH1,ASAH2,UGT8,PLPP2,PLPP3,CERK,KDSR,CERS4,SGPP1,CERS1,SPTLC3,ACER3,SGMS2,SMPD4,NEU3,DEGS2,SMPD1,CERS5,SMPD3,SMPD2,NEU1,SGPP2,CERS3
hsa04672	Intestinal immune network for IgA production	0.317828361593018	-1.14624378533406	47	43	0.00682539682539683	6300	7161	942,23495,3118,3109,3676,3600,8741,3695,23308,941,3567,3569,56477,9020,7852,6387,5284,6370,8174,3558,2826,3127,940,57379,958,10803,3112,3113,3565,7040,29851,3117,115650,3111,3108,4055,608,3601,3122,10673,3586,3123,3119	CD86,TNFRSF13B,HLA-DQA2,HLA-DMB,ITGA4,IL15,TNFSF13,ITGB7,ICOSLG,CD80,IL5,IL6,CCL28,MAP3K14,CXCR4,CXCL12,PIGR,CCL25,MADCAM1,IL2,CCR10,HLA-DRB5,CD28,AICDA,CD40,CCR9,HLA-DOB,HLA-DPA1,IL4,TGFB1,ICOS,HLA-DQA1,TNFRSF13C,HLA-DOA,HLA-DMA,LTBR,TNFRSF17,IL15RA,HLA-DRA,TNFSF13B,IL10,HLA-DRB1,HLA-DQB1
hsa00830	Retinol metabolism	0.320467053549696	-1.13797580494222	65	59	0.00936507936507936	6300	7161	125,56603,53630,8854,1543,216,79799,54884,7365,145226,1592,9249,124,50700,316,5959,130,54578,157506,51109,317749,728635,54658,7364,128,574537,1559,131,127,54600,1548,8608,6121,7363,1558,1555,100861540,29785,54490,10170,10941,126,195814,54575,9227,1544,1576,54659,7366,54657,1577,8630,10901,1562,1579,10720,54579,54577,54576	ADH1B,CYP26B1,BCO1,ALDH1A2,CYP1A1,ALDH1A1,UGT2A3,RETSAT,UGT2B10,RDH12,CYP26A1,DHRS3,ADH1A,RDH8,AOX1,RDH5,ADH6,UGT1A6,RDH10,RDH11,DHRS4L2,DHRS4L1,UGT1A1,UGT2B7,ADH5,UGT2A2,CYP2C9,ADH7,ADH4,UGT1A9,CYP2A6,RDH16,RPE65,UGT2B4,CYP2C8,CYP2B6,CYP3A7-CYP3A51P,CYP2S1,UGT2B28,DHRS9,UGT2A1,ADH1C,SDR16C5,UGT1A10,LRAT,CYP1A2,CYP3A4,UGT1A3,UGT2B15,UGT1A4,CYP3A5,HSD17B6,DHRS4,CYP2C18,CYP4A11,UGT2B11,UGT1A5,UGT1A7,UGT1A8
ko05321	Inflammatory bowel disease (IBD)	0.320467053549696	-1.13797580494222	65	59	0.00936507936507936	6300	7161	8809,59067,3569,3458,3595,3725,50616,3558,7097,4087,149233,3566,7099,50615,3567,8807,3118,3594,3605,64127,7124,7042,7043,3109,30009,6095,6772,6097,4772,4790,3592,3593,3111,3108,3122,3552,3123,3553,3586,3119,7100,6774,3117,2625,3606,112744,3112,3460,3113,4094,3565,7040,3459,3596,4088,5970,3127,6778,6775	IL18R1,IL21,IL6,IFNG,IL12RB2,JUN,IL22,IL2,TLR2,SMAD2,IL23R,IL4R,TLR4,IL21R,IL5,IL18RAP,HLA-DQA2,IL12RB1,IL17A,NOD2,TNF,TGFB2,TGFB3,HLA-DMB,TBX21,RORA,STAT1,RORC,NFATC1,NFKB1,IL12A,IL12B,HLA-DOA,HLA-DMA,HLA-DRA,IL1A,HLA-DRB1,IL1B,IL10,HLA-DQB1,TLR5,STAT3,HLA-DQA1,GATA3,IL18,IL17F,HLA-DOB,IFNGR2,HLA-DPA1,MAF,IL4,TGFB1,IFNGR1,IL13,SMAD3,RELA,HLA-DRB5,STAT6,STAT4
hsa05321	Inflammatory bowel disease (IBD)	0.320467053549696	-1.13797580494222	65	59	0.00936507936507936	6300	7161	4094,3460,3113,3112,3459,7040,3565,6775,6778,3127,5970,4088,3596,3111,3108,3593,3592,4790,4772,6097,7100,3119,3586,3553,3123,3122,3552,3606,2625,3117,6774,112744,3118,7043,3109,7042,7124,64127,3605,3594,6095,30009,6772,3458,3595,3569,59067,8809,4087,7097,3558,50616,3725,50615,3566,7099,149233,8807,3567	MAF,IFNGR2,HLA-DPA1,HLA-DOB,IFNGR1,TGFB1,IL4,STAT4,STAT6,HLA-DRB5,RELA,SMAD3,IL13,HLA-DOA,HLA-DMA,IL12B,IL12A,NFKB1,NFATC1,RORC,TLR5,HLA-DQB1,IL10,IL1B,HLA-DRB1,HLA-DRA,IL1A,IL18,GATA3,HLA-DQA1,STAT3,IL17F,HLA-DQA2,TGFB3,HLA-DMB,TGFB2,TNF,NOD2,IL17A,IL12RB1,RORA,TBX21,STAT1,IFNG,IL12RB2,IL6,IL21,IL18R1,SMAD2,TLR2,IL2,IL22,JUN,IL21R,IL4R,TLR4,IL23R,IL18RAP,IL5
ko00830	Retinol metabolism	0.320467053549696	-1.13797580494222	65	59	0.00936507936507936	6300	7161	8854,1543,53630,56603,125,50700,124,9249,145226,1592,7365,79799,54884,216,317749,51109,157506,54578,130,5959,316,1559,128,574537,7364,54658,728635,8608,54600,1548,127,131,10941,10170,29785,54490,1558,100861540,1555,7363,6121,1577,54657,54659,7366,1576,1544,54575,9227,195814,126,54576,54577,54579,10720,1579,1562,8630,10901	ALDH1A2,CYP1A1,BCO1,CYP26B1,ADH1B,RDH8,ADH1A,DHRS3,RDH12,CYP26A1,UGT2B10,UGT2A3,RETSAT,ALDH1A1,DHRS4L2,RDH11,RDH10,UGT1A6,ADH6,RDH5,AOX1,CYP2C9,ADH5,UGT2A2,UGT2B7,UGT1A1,DHRS4L1,RDH16,UGT1A9,CYP2A6,ADH4,ADH7,UGT2A1,DHRS9,CYP2S1,UGT2B28,CYP2C8,CYP3A7-CYP3A51P,CYP2B6,UGT2B4,RPE65,CYP3A5,UGT1A4,UGT1A3,UGT2B15,CYP3A4,CYP1A2,UGT1A10,LRAT,SDR16C5,ADH1C,UGT1A8,UGT1A7,UGT1A5,UGT2B11,CYP4A11,CYP2C18,HSD17B6,DHRS4
hsa05016	Huntington's disease	0.333700594915041	-1.09751111044234	187	167	0.0265079365079365	6300	7161	56901,5432,5433,6648,51079,5332,1351,1767,4726,6667,6875,387332,548644,170712,539,8632,7386,1347,440567,516,29796,246721,83447,7381,4704,627,10891,4696,1769,506,2915,1173,4712,8218,3066,9167,6874,27019,4717,5439,83544,25981,10105,84699,55081,5441,27113,23236,317,4719,25942,4705,5978,1211,5430,4706,5330,51164,196385,7157,1742,148327,4724,201625,3065,1385,4718,7384,4710,4731,161,6391,7417,842,4695,10540,514,3064,1768,7385,7052,6647,4725,7419,3092,1340,9377,341947,2876,10975,3708,160,1346,1339,10476,9586,6390,374291,7019,581,1337,127602,4729,4697,1639,4716,5331,5431,10488,5468,1387,56171,498,2776,4722,4723,4708,4711,4700,517,163,841,55567,2033,126328,64446,146754,518,4707,7350,55967,6392,291,2904,4709,54205,6389,5440,23186,1175,1770,4899,90993,4715,7416,1350,1213,1212,4698,1327,64764,5434,522,4714,9519,509,10126,836,1329,515,4720,4728,1345,7802,4702,8701,513	NDUFA4L2,POLR2C,POLR2D,SOD2,NDUFA13,PLCB4,COX8A,DNAH5,NDUFS6,SP1,TAF4B,TBPL2,POLR2J3,COX7B2,ATP5PO,DNAH17,UQCRFS1,COX7A2,UQCRHL,ATP5MC1,UQCR10,POLR2J2,SLC25A31,UQCRB,NDUFA9,BDNF,PPARGC1A,NDUFA3,DNAH8,ATP5F1B,GRM5,AP2M1,NDUFB6,CLTCL1,HDAC2,COX7A2L,TAF4,DNAI1,NDUFC1,POLR2J,DNAL1,DNAH1,PPIF,CREB3L3,IFT57,POLR2L,BBC3,PLCB1,APAF1,NDUFS1,SIN3A,NDUFA10,REST,CLTA,POLR2A,NDUFAB1,PLCB2,DCTN4,DNAH10,TP53,DLG4,CREB3L4,NDUFS4,DNAH12,HDAC1,CREB1,NDUFC2,UQCRC1,NDUFB4,NDUFV3,AP2A2,SDHC,VDAC2,CASP9,NDUFA2,DCTN2,ATP5F1E,HTT,DNAH6,UQCRC2,TGM2,SOD1,NDUFS5,VDAC3,HIP1,COX6B1,COX5A,COX8C,GPX1,UQCR11,ITPR1,AP2A1,COX7A1,COX6A2,ATP5PD,CREB5,SDHB,NDUFS7,TFAM,BAX,COX6A1,DNAH14,NDUFV2,NDUFA4,DCTN1,NDUFB10,PLCB3,POLR2B,CREB3,PPARG,CREBBP,DNAH7,ATP5F1A,GNAQ,NDUFS3,NDUFV1,NDUFB2,NDUFB5,NDUFA6,ATP5MC2,AP2B1,CASP8,DNAH3,EP300,NDUFA11,DNAI2,DNAH2,ATP5MC3,NDUFB1,UCP1,NDUFA12,SDHD,SLC25A4,GRIN2B,NDUFB3,CYCS,SDHA,POLR2K,RCOR1,AP2S1,DNAH9,NRF1,CREB3L1,NDUFB9,VDAC1,COX7C,CLTC,CLTB,NDUFA5,COX4I1,CREB3L2,POLR2E,ATP5PF,NDUFB8,TBPL1,ATP5F1C,DNAL4,CASP3,COX5B,ATP5PB,NDUFS2,NDUFS8,COX6C,DNALI1,NDUFA8,DNAH11,ATP5F1D
ko05016	Huntington's disease	0.333700594915041	-1.09751111044234	187	167	0.0265079365079365	6300	7161	5431,10488,4716,5331,56171,1387,5468,4723,4722,2776,498,163,517,4700,4711,4708,1346,1339,10975,2876,341947,160,3708,6390,9586,7019,374291,10476,581,127602,1639,4697,4729,1337,1212,1213,7416,1350,522,5434,4698,64764,1327,1329,836,4720,4728,515,9519,509,4714,10126,4702,7802,1345,8701,513,2033,126328,841,55567,7350,4707,55967,6392,146754,64446,518,6389,5440,54205,2904,291,4709,4899,4715,90993,23186,1175,1770,6874,9167,3066,10105,25981,55081,84699,4717,27019,83544,5439,317,4719,25942,27113,5441,23236,5978,4705,5332,51079,1767,1351,5433,5432,56901,6648,539,7386,1347,8632,387332,6667,6875,4726,548644,170712,7381,10891,4704,627,4696,29796,516,440567,83447,246721,8218,4712,1769,1173,506,2915,161,4731,514,842,4695,10540,6391,7417,6647,7419,3092,4725,7385,1768,3064,7052,9377,1340,4706,5330,1211,5430,7157,196385,1742,51164,148327,4718,7384,4710,3065,1385,4724,201625	POLR2B,CREB3,NDUFB10,PLCB3,DNAH7,CREBBP,PPARG,NDUFV1,NDUFS3,GNAQ,ATP5F1A,AP2B1,ATP5MC2,NDUFA6,NDUFB5,NDUFB2,COX7A1,COX6A2,UQCR11,GPX1,COX8C,AP2A1,ITPR1,SDHB,CREB5,TFAM,NDUFS7,ATP5PD,BAX,DNAH14,DCTN1,NDUFA4,NDUFV2,COX6A1,CLTB,CLTC,VDAC1,COX7C,ATP5PF,POLR2E,NDUFA5,CREB3L2,COX4I1,COX5B,CASP3,NDUFS2,NDUFS8,ATP5PB,TBPL1,ATP5F1C,NDUFB8,DNAL4,NDUFA8,DNALI1,COX6C,DNAH11,ATP5F1D,EP300,NDUFA11,CASP8,DNAH3,UCP1,NDUFB1,NDUFA12,SDHD,DNAH2,DNAI2,ATP5MC3,SDHA,POLR2K,CYCS,GRIN2B,SLC25A4,NDUFB3,NRF1,NDUFB9,CREB3L1,RCOR1,AP2S1,DNAH9,TAF4,COX7A2L,HDAC2,PPIF,DNAH1,IFT57,CREB3L3,NDUFC1,DNAI1,DNAL1,POLR2J,APAF1,NDUFS1,SIN3A,BBC3,POLR2L,PLCB1,REST,NDUFA10,PLCB4,NDUFA13,DNAH5,COX8A,POLR2D,POLR2C,NDUFA4L2,SOD2,ATP5PO,UQCRFS1,COX7A2,DNAH17,TBPL2,SP1,TAF4B,NDUFS6,POLR2J3,COX7B2,UQCRB,PPARGC1A,NDUFA9,BDNF,NDUFA3,UQCR10,ATP5MC1,UQCRHL,SLC25A31,POLR2J2,CLTCL1,NDUFB6,DNAH8,AP2M1,ATP5F1B,GRM5,AP2A2,NDUFV3,ATP5F1E,CASP9,NDUFA2,DCTN2,SDHC,VDAC2,SOD1,VDAC3,HIP1,NDUFS5,UQCRC2,DNAH6,HTT,TGM2,COX5A,COX6B1,NDUFAB1,PLCB2,CLTA,POLR2A,TP53,DNAH10,DLG4,DCTN4,CREB3L4,NDUFC2,UQCRC1,NDUFB4,HDAC1,CREB1,NDUFS4,DNAH12
ko04742	Taste transduction	0.33375672159267	-1.09734292986697	82	74	0.0117460317460317	6300	7161	775,9033,259286,6337,1131,6328,2555,5153,773,2550,2558,2911,196883,3710,5024,50838,54429,3354,83756,2554,51764,5567,259290,259289,346562,5566,8645,170572,259295,3350,114,3355,5330,5137,50833,5028,259292,5136,200909,10021,259287,50839,2914,50837,80835,338398,5726,112,3351,50832,5568,259296,9568,29850,285242,50835,3359,2784,255022,50834,50831,2559,259294,6340,40,6326,259285,342372,80834,3352,2557,9177,6335,6338	CACNA1C,PKD2L1,TAS2R40,SCNN1A,CHRM3,SCN3A,GABRA2,PDE1B,CACNA1A,GABBR1,GABRA5,GRM1,ADCY4,ITPR3,P2RX3,TAS2R13,TAS2R5,HTR1E,TAS1R3,GABRA1,GNG13,PRKACB,TAS2R31,TAS2R43,GNAT3,PRKACA,KCNK5,HTR3C,TAS2R20,HTR1A,ADCY8,HTR1F,PLCB2,PDE1C,TAS2R16,P2RY1,TAS2R46,PDE1A,HTR3D,HCN4,TAS2R41,TAS2R10,GRM4,TAS2R7,TAS1R1,TAS2R60,TAS2R38,ADCY6,HTR1B,TAS2R4,PRKACG,TAS2R50,GABBR2,TRPM5,HTR3E,TAS2R9,HTR3A,GNB3,CALHM1,TAS2R1,TAS2R3,GABRA6,TAS2R19,SCNN1G,ASIC2,SCN2A,TAS2R39,PKD1L3,TAS1R2,HTR1D,GABRA4,HTR3B,SCN9A,SCNN1B
hsa04742	Taste transduction	0.33375672159267	-1.09734292986697	82	74	0.0117460317460317	6300	7161	5137,5330,3355,114,3350,200909,5136,259292,5028,50833,259289,51764,5567,259290,2554,259295,170572,8645,5566,346562,3710,5024,196883,83756,3354,54429,50838,9033,775,2558,2911,2550,5153,2555,773,6328,1131,6337,259286,3352,80834,342372,6326,259285,6338,6335,9177,2557,259294,50831,2559,50834,255022,2784,6340,40,259296,5568,50832,3351,112,3359,50835,285242,29850,9568,50837,2914,50839,259287,10021,5726,80835,338398	PDE1C,PLCB2,HTR1F,ADCY8,HTR1A,HTR3D,PDE1A,TAS2R46,P2RY1,TAS2R16,TAS2R43,GNG13,PRKACB,TAS2R31,GABRA1,TAS2R20,HTR3C,KCNK5,PRKACA,GNAT3,ITPR3,P2RX3,ADCY4,TAS1R3,HTR1E,TAS2R5,TAS2R13,PKD2L1,CACNA1C,GABRA5,GRM1,GABBR1,PDE1B,GABRA2,CACNA1A,SCN3A,CHRM3,SCNN1A,TAS2R40,HTR1D,TAS1R2,PKD1L3,SCN2A,TAS2R39,SCNN1B,SCN9A,HTR3B,GABRA4,TAS2R19,TAS2R3,GABRA6,TAS2R1,CALHM1,GNB3,SCNN1G,ASIC2,TAS2R50,PRKACG,TAS2R4,HTR1B,ADCY6,HTR3A,TAS2R9,HTR3E,TRPM5,GABBR2,TAS2R7,GRM4,TAS2R10,TAS2R41,HCN4,TAS2R38,TAS1R1,TAS2R60
hsa05131	Shigellosis	0.336685392574725	-1.08860633785268	64	58	0.00920634920634921	6300	7161	71,10095,9474,5603,5602,960,5599,1432,3551,5879,2017,10092,375189,7414,6300,10109,10163,9844,79767,5970,8767,23291,1729,4790,5601,7307,998,6714,9475,10392,63916,8936,10094,5600,3688,5594,345456,391,25,81873,60,64127,1398,7322,5216,10552,1147,10459,5217,8945,3576,10093,4793,4792,5595,3059,8976,1793	ACTG1,ARPC1B,ATG5,MAPK13,MAPK10,CD44,MAPK8,MAPK14,IKBKB,RAC1,CTTN,ARPC5,PFN4,VCL,MAPK12,ARPC2,WASF2,ELMO1,ELMO3,RELA,RIPK2,FBXW11,DIAPH1,NFKB1,MAPK9,U2AF1,CDC42,SRC,ROCK2,NOD1,ELMO2,WASF1,ARPC3,MAPK11,ITGB1,MAPK1,PFN3,RHOG,ABL1,ARPC5L,ACTB,NOD2,CRK,UBE2D2,PFN1,ARPC1A,CHUK,MAD2L2,PFN2,BTRC,CXCL8,ARPC4,NFKBIB,NFKBIA,MAPK3,HCLS1,WASL,DOCK1
ko00770	Pantothenate and CoA biosynthesis	0.344543589735592	-1.06553466609559	18	17	0.0026984126984127	6300	7161	339896,53354,60496,60490,80025,8875,51733,5169,5167,8876,587,1806,79646,79717,55229,586,1807	GADL1,PANK1,AASDHPPT,PPCDC,PANK2,VNN2,UPB1,ENPP3,ENPP1,VNN1,BCAT2,DPYD,PANK3,PPCS,PANK4,BCAT1,DPYS
hsa00770	Pantothenate and CoA biosynthesis	0.344543589735592	-1.06553466609559	18	17	0.0026984126984127	6300	7161	339896,53354,60490,60496,5169,51733,8875,80025,8876,5167,1806,587,79646,1807,586,55229,79717	GADL1,PANK1,PPCDC,AASDHPPT,ENPP3,UPB1,VNN2,PANK2,VNN1,ENPP1,DPYD,BCAT2,PANK3,DPYS,BCAT1,PANK4,PPCS
ko03320	PPAR signaling pathway	0.351076026397181	-1.04675247954837	72	65	0.0103174603174603	6300	7161	51,376497,28965,1593,30,5346,5360,5468,2171,5465,123,948,1581,729359,6319,2180,4023,10062,10999,8309,1374,8310,2173,5105,2172,2169,335,364,9370,345,2712,9415,1582,6258,2167,23305,2168,7316,3611,440503,4199,6256,23205,116519,336,4312,51703,5170,1962,79966,11001,10580,1622,7350,2170,4973,81616,51129,1376,5467,33,126129,34,6342,2181	ACOX1,SLC27A1,SLC27A6,CYP27A1,ACAA1,PLIN1,PLTP,PPARG,FABP5,PPARA,PLIN2,CD36,CYP7A1,PLIN4,SCD,ACSL1,LPL,NR1H3,SLC27A4,ACOX2,CPT1A,ACOX3,FABP7,PCK1,FABP6,FABP2,APOA1,AQP7,ADIPOQ,APOC3,GK2,FADS2,CYP8B1,RXRG,FABP4,ACSL6,FABP1,UBC,ILK,PLIN5,ME1,RXRA,ACSBG1,APOA5,APOA2,MMP1,ACSL5,PDPK1,EHHADH,SCD5,SLC27A2,SORBS1,DBI,UCP1,FABP3,OLR1,ACSBG2,ANGPTL4,CPT2,PPARD,ACADL,CPT1C,ACADM,SCP2,ACSL3
hsa03320	PPAR signaling pathway	0.351076026397181	-1.04675247954837	72	65	0.0103174603174603	6300	7161	79966,1962,11001,51703,5170,3611,440503,4199,6256,23205,116519,336,4312,2168,7316,33,5467,126129,34,6342,2181,81616,51129,1376,7350,2170,4973,10580,1622,6319,2180,4023,10062,123,948,1581,729359,5346,5360,5468,2171,5465,376497,51,28965,1593,30,23305,2712,9415,1582,6258,2167,5105,8310,2173,335,2169,2172,364,9370,345,10999,8309,1374	SCD5,EHHADH,SLC27A2,ACSL5,PDPK1,ILK,PLIN5,ME1,RXRA,ACSBG1,APOA5,APOA2,MMP1,FABP1,UBC,ACADL,PPARD,CPT1C,ACADM,SCP2,ACSL3,ACSBG2,ANGPTL4,CPT2,UCP1,FABP3,OLR1,SORBS1,DBI,SCD,ACSL1,LPL,NR1H3,PLIN2,CD36,CYP7A1,PLIN4,PLIN1,PLTP,PPARG,FABP5,PPARA,SLC27A1,ACOX1,SLC27A6,CYP27A1,ACAA1,ACSL6,GK2,FADS2,CYP8B1,RXRG,FABP4,PCK1,ACOX3,FABP7,APOA1,FABP2,FABP6,AQP7,ADIPOQ,APOC3,SLC27A4,ACOX2,CPT1A
hsa_M00056	O-glycan biosynthesis, mucin type core	0.353453820914865	-1.04000243608306	27	25	0.00396825396825397	6300	7161	50614,2589,2650,374378,9245,57452,51301,8693,26290,168391,64409,114805,192134,56913,51809,79695,442117,117248,55568,11226,2590,79623,2591,11227,63917	GALNT9,GALNT1,GCNT1,GALNT18,GCNT3,GALNT16,GCNT4,GALNT4,GALNT8,GALNTL5,GALNT17,GALNT13,B3GNT6,C1GALT1,GALNT7,GALNT12,GALNTL6,GALNT15,GALNT10,GALNT6,GALNT2,GALNT14,GALNT3,GALNT5,GALNT11
M00056	O-glycan biosynthesis, mucin type core	0.353453820914865	-1.04000243608306	27	25	0.00396825396825397	6300	7161	2589,50614,2650,374378,51301,64409,168391,26290,56913,117248,51809,2590,8693,57452,9245,114805,192134,442117,55568,79695,79623,11226,2591,11227,63917	GALNT1,GALNT9,GCNT1,GALNT18,GCNT4,GALNT17,GALNTL5,GALNT8,C1GALT1,GALNT15,GALNT7,GALNT2,GALNT4,GALNT16,GCNT3,GALNT13,B3GNT6,GALNTL6,GALNT10,GALNT12,GALNT14,GALNT6,GALNT3,GALNT5,GALNT11
ko00500	Starch and sucrose metabolism	0.356251380189208	-1.03211867319146	36	33	0.00523809523809524	6300	7161	280,279,57818,80201,2998,2992,3099,11181,92579,5834,8972,5167,276,2821,5236,7360,2548,3101,2632,178,283209,5836,2645,5837,3098,93432,2997,6476,57733,2538,55276,5169,2595	AMY2B,AMY2A,G6PC2,HKDC1,GYS2,GYG1,HK2,TREH,G6PC3,PYGB,MGAM,ENPP1,AMY1A,GPI,PGM1,UGP2,GAA,HK3,GBE1,AGL,PGM2L1,PYGL,GCK,PYGM,HK1,MGAM2,GYS1,SI,GBA3,G6PC1,PGM2,ENPP3,GANC
hsa00500	Starch and sucrose metabolism	0.356251380189208	-1.03211867319146	36	33	0.00523809523809524	6300	7161	7360,5236,2821,276,5167,8972,5834,283209,178,2632,3101,2548,5836,2538,5169,55276,2595,57733,6476,2997,3098,5837,93432,2645,280,2992,2998,80201,57818,279,92579,11181,3099	UGP2,PGM1,GPI,AMY1A,ENPP1,MGAM,PYGB,PGM2L1,AGL,GBE1,HK3,GAA,PYGL,G6PC1,ENPP3,PGM2,GANC,GBA3,SI,GYS1,HK1,PYGM,MGAM2,GCK,AMY2B,GYG1,GYS2,HKDC1,G6PC2,AMY2A,G6PC3,TREH,HK2
hsa_M00680	TGF-beta signaling	0.358676361897689	-1.0253347959806	8	8	0.00126984126984127	6300	7161	4089,7046,4088,7048,4087,7040,7042,7043	SMAD4,TGFBR1,SMAD3,TGFBR2,SMAD2,TGFB1,TGFB2,TGFB3
M00680	TGF-beta signaling	0.358676361897689	-1.0253347959806	8	8	0.00126984126984127	6300	7161	4087,7040,7048,7043,7042,4088,4089,7046	SMAD2,TGFB1,TGFBR2,TGFB3,TGFB2,SMAD3,SMAD4,TGFBR1
hsa_M00077	Chondroitin sulfate degradation	0.358676361897689	-1.0253347959806	8	8	0.00126984126984127	6300	7161	8372,23553,411,2588,6677,2990,8692,3373	HYAL3,HYAL4,ARSB,GALNS,SPAM1,GUSB,HYAL2,HYAL1
M00077	Chondroitin sulfate degradation	0.358676361897689	-1.0253347959806	8	8	0.00126984126984127	6300	7161	3373,8692,6677,2588,2990,23553,8372,411	HYAL1,HYAL2,SPAM1,GALNS,GUSB,HYAL4,HYAL3,ARSB
hsa05323	Rheumatoid arthritis	0.360056739712131	-1.02149364963971	89	80	0.0126984126984127	6300	7161	942,526,7422,2919,6349,8600,1513,3576,155066,7010,3118,8792,284,90423,245972,6374,3605,414062,3600,6347,2321,7124,1435,7042,4312,127124,3109,7043,54,7099,8741,941,51382,6352,3569,3458,3725,9550,7097,6387,50617,6364,9114,2353,23545,3383,940,3127,3112,3113,51606,3683,528,8992,7040,1493,525,3117,1514,3606,529,523,10312,1437,6348,245973,4314,3111,535,4050,3108,3122,3552,10673,6372,3553,3123,3119,533,3689	CD86,ATP6V1B2,VEGFA,CXCL1,CCL3L1,TNFSF11,CTSK,CXCL8,ATP6V0E2,TEK,HLA-DQA2,TNFRSF11A,ANGPT1,ATP6V1E2,ATP6V0D2,CXCL5,IL17A,CCL3L3,IL15,CCL2,FLT1,TNF,CSF1,TGFB2,MMP1,ATP6V1G3,HLA-DMB,TGFB3,ACP5,TLR4,TNFSF13,CD80,ATP6V1D,CCL5,IL6,IFNG,JUN,ATP6V1G1,TLR2,CXCL12,ATP6V0A4,CCL20,ATP6V0D1,FOS,ATP6V0A2,ICAM1,CD28,HLA-DRB5,HLA-DOB,HLA-DPA1,ATP6V1H,ITGAL,ATP6V1C1,ATP6V0E1,TGFB1,CTLA4,ATP6V1B1,HLA-DQA1,CTSL,IL18,ATP6V1E1,ATP6V1A,TCIRG1,CSF2,CCL3,ATP6V1C2,MMP3,HLA-DOA,ATP6V0A1,LTB,HLA-DMA,HLA-DRA,IL1A,TNFSF13B,CXCL6,IL1B,HLA-DRB1,HLA-DQB1,ATP6V0B,ITGB2
ko05323	Rheumatoid arthritis	0.360056739712131	-1.02149364963971	89	80	0.0126984126984127	6300	7161	2353,3127,940,3383,23545,3683,51606,3113,3112,1493,7040,8992,528,3606,1514,3117,525,245973,6348,10312,1437,523,529,3111,4050,535,3108,4314,3689,533,3119,3553,6372,3123,3552,10673,3122,8600,6349,2919,7422,526,942,155066,3576,1513,6374,90423,245972,284,8792,3118,7010,3109,7043,127124,7042,4312,1435,7124,2321,6347,414062,3600,3605,8741,7099,54,51382,941,3458,3569,6352,6364,9114,7097,6387,50617,9550,3725	FOS,HLA-DRB5,CD28,ICAM1,ATP6V0A2,ITGAL,ATP6V1H,HLA-DPA1,HLA-DOB,CTLA4,TGFB1,ATP6V0E1,ATP6V1C1,IL18,CTSL,HLA-DQA1,ATP6V1B1,ATP6V1C2,CCL3,TCIRG1,CSF2,ATP6V1A,ATP6V1E1,HLA-DOA,LTB,ATP6V0A1,HLA-DMA,MMP3,ITGB2,ATP6V0B,HLA-DQB1,IL1B,CXCL6,HLA-DRB1,IL1A,TNFSF13B,HLA-DRA,TNFSF11,CCL3L1,CXCL1,VEGFA,ATP6V1B2,CD86,ATP6V0E2,CXCL8,CTSK,CXCL5,ATP6V1E2,ATP6V0D2,ANGPT1,TNFRSF11A,HLA-DQA2,TEK,HLA-DMB,TGFB3,ATP6V1G3,TGFB2,MMP1,CSF1,TNF,FLT1,CCL2,CCL3L3,IL15,IL17A,TNFSF13,TLR4,ACP5,ATP6V1D,CD80,IFNG,IL6,CCL5,CCL20,ATP6V0D1,TLR2,CXCL12,ATP6V0A4,ATP6V1G1,JUN
ko04650	Natural killer cell mediated cytotoxicity	0.366512820906484	-1.00372177625778	132	118	0.0187301587301587	6300	7161	3002,259197,7535,25759,5530,3455,100528032,27040,3448,3440,10451,154064,3824,3384,8797,5295,4277,962,3454,8793,356,5579,117157,7305,3133,3107,79465,5578,5533,5532,5777,3821,3442,3443,6655,7410,3804,80329,3812,5296,5879,8503,353091,3460,100507436,9437,3456,2185,5582,5880,3449,3805,5291,3265,6654,80328,5595,5604,5535,6464,3458,6452,5335,6850,3445,135250,3809,2534,22914,5881,5290,7124,5594,5605,5534,5781,53358,3106,3802,919,4893,8743,3444,836,3689,8794,2885,51744,3452,3105,4773,355,4772,3937,3845,1437,2214,7409,5293,399694,3459,5894,3683,8795,2207,5551,3439,3383,5336,3441,3135,3823,3811,673,2215,3932,9436,5058	GZMB,NCR3,ZAP70,SHC2,PPP3CA,IFNAR2,KLRC4-KLRK1,LAT,IFNA14,IFNA2,VAV3,RAET1L,KLRD1,ICAM2,TNFRSF10A,PIK3R1,MICB,CD48,IFNAR1,TNFRSF10D,FASLG,PRKCB,SH2D1B,TYROBP,HLA-E,HLA-C,ULBP3,PRKCA,PPP3CC,PPP3CB,PTPN6,KLRC1,IFNA5,IFNA6,SOS2,VAV2,KIR2DL3,ULBP1,KIR3DL2,PIK3R2,RAC1,PIK3R3,RAET1G,IFNGR2,MICA,NCR1,IFNB1,PTK2B,PRKCG,RAC2,IFNA16,KIR2DL4,PIK3CB,HRAS,SOS1,ULBP2,MAPK3,MAP2K1,PPP3R2,SHC1,IFNG,SH3BP2,PLCG1,SYK,IFNA8,RAET1E,KIR2DS4,FYN,KLRK1,RAC3,PIK3CA,TNF,MAPK1,MAP2K2,PPP3R1,PTPN11,SHC3,HLA-B,KIR2DL1,CD247,NRAS,TNFSF10,IFNA7,CASP3,ITGB2,TNFRSF10C,GRB2,CD244,IFNA21,HLA-A,NFATC2,FAS,NFATC1,LCP2,KRAS,CSF2,FCGR3A,VAV1,PIK3CD,SHC4,IFNGR1,RAF1,ITGAL,TNFRSF10B,FCER1G,PRF1,IFNA1,ICAM1,PLCG2,IFNA4,HLA-G,KLRC3,KIR3DL1,BRAF,FCGR3B,LCK,NCR2,PAK1
hsa04650	Natural killer cell mediated cytotoxicity	0.366512820906484	-1.00372177625778	132	118	0.0187301587301587	6300	7161	5532,5533,5578,5777,6655,3443,3442,3821,3804,7410,3812,80329,5879,5296,8503,3460,353091,9437,100507436,5582,2185,3456,3265,5291,3805,5880,3449,6654,259197,7535,3002,5530,25759,3455,100528032,27040,3448,10451,3440,3824,154064,5295,4277,8797,3384,962,3454,356,8793,5579,117157,3133,7305,3107,79465,3689,2885,8794,3105,3452,51744,3937,4772,4773,355,3845,2214,1437,7409,5293,3459,399694,5894,2207,8795,3683,3439,5551,5336,3383,3823,3135,3441,9436,3932,2215,673,3811,5058,80328,6464,5535,5595,5604,3458,6850,5335,6452,3809,3445,135250,2534,22914,5290,5881,7124,5534,5594,5605,53358,5781,3106,3802,836,3444,8743,4893,919	PPP3CB,PPP3CC,PRKCA,PTPN6,SOS2,IFNA6,IFNA5,KLRC1,KIR2DL3,VAV2,KIR3DL2,ULBP1,RAC1,PIK3R2,PIK3R3,IFNGR2,RAET1G,NCR1,MICA,PRKCG,PTK2B,IFNB1,HRAS,PIK3CB,KIR2DL4,RAC2,IFNA16,SOS1,NCR3,ZAP70,GZMB,PPP3CA,SHC2,IFNAR2,KLRC4-KLRK1,LAT,IFNA14,VAV3,IFNA2,KLRD1,RAET1L,PIK3R1,MICB,TNFRSF10A,ICAM2,CD48,IFNAR1,FASLG,TNFRSF10D,PRKCB,SH2D1B,HLA-E,TYROBP,HLA-C,ULBP3,ITGB2,GRB2,TNFRSF10C,HLA-A,IFNA21,CD244,LCP2,NFATC1,NFATC2,FAS,KRAS,FCGR3A,CSF2,VAV1,PIK3CD,IFNGR1,SHC4,RAF1,FCER1G,TNFRSF10B,ITGAL,IFNA1,PRF1,PLCG2,ICAM1,KLRC3,HLA-G,IFNA4,NCR2,LCK,FCGR3B,BRAF,KIR3DL1,PAK1,ULBP2,SHC1,PPP3R2,MAPK3,MAP2K1,IFNG,SYK,PLCG1,SH3BP2,KIR2DS4,IFNA8,RAET1E,FYN,KLRK1,PIK3CA,RAC3,TNF,PPP3R1,MAPK1,MAP2K2,SHC3,PTPN11,HLA-B,KIR2DL1,CASP3,IFNA7,TNFSF10,NRAS,CD247
hsa04727	GABAergic synapse	0.374665005437423	-0.981722971092323	88	79	0.0125396825396825	6300	7161	2773,6714,5578,2790,66008,111,2557,6538,23710,6529,2560,2568,107,2565,94235,776,3763,2559,81539,2784,6540,140679,9568,54407,2771,11337,10991,5568,10681,112,5582,18,2788,59345,2744,2570,2792,2793,2770,27165,10243,2787,114,2752,2786,115,54331,109,5566,2563,2562,2571,2554,11345,113,5567,51764,2567,5334,108,2791,5579,2566,196883,55970,2783,2561,2782,773,2555,779,2558,2550,57468,4905,2572,2569,200959,775	GNAI3,SRC,PRKCA,GNG10,TRAK2,ADCY5,GABRA4,SLC6A11,GABARAPL1,SLC6A1,GABRB1,GABRP,ADCY1,GABRG1,GNG8,CACNA1D,KCNJ6,GABRA6,SLC38A1,GNB3,SLC6A13,SLC32A1,GABBR2,SLC38A2,GNAI2,GABARAP,SLC38A3,PRKACG,GNB5,ADCY6,PRKCG,ABAT,GNG7,GNB4,GLS,GABRR2,GNGT1,GNGT2,GNAI1,GLS2,GPHN,GNG5,ADCY8,GLUL,GNG4,ADCY9,GNG2,ADCY3,PRKACA,GABRD,GABRB3,GAD1,GABRA1,GABARAPL2,ADCY7,PRKACB,GNG13,GABRG3,PLCL1,ADCY2,GNG11,PRKCB,GABRG2,ADCY4,GNG12,GNB2,GABRB2,GNB1,CACNA1A,GABRA2,CACNA1S,GABRA5,GABBR1,SLC12A5,NSF,GAD2,GABRR1,GABRR3,CACNA1C
ko04727	GABAergic synapse	0.374665005437423	-0.981722971092323	88	79	0.0125396825396825	6300	7161	55970,196883,2566,5579,5334,108,2791,2567,2569,2572,775,200959,4905,57468,2782,2561,2783,2558,2550,779,773,2555,2786,2752,114,2787,2793,2792,10243,27165,2770,2554,11345,5567,113,51764,2571,109,2562,5566,2563,54331,115,112,10991,5568,11337,10681,9568,2771,54407,2570,59345,2744,18,5582,2788,6538,23710,2557,66008,111,6714,2773,2790,5578,2784,81539,140679,6540,3763,776,2559,2565,2560,2568,107,94235,6529	GNG12,ADCY4,GABRG2,PRKCB,PLCL1,ADCY2,GNG11,GABRG3,GABRR1,GAD2,CACNA1C,GABRR3,NSF,SLC12A5,GNB1,GABRB2,GNB2,GABRA5,GABBR1,CACNA1S,CACNA1A,GABRA2,GNG4,GLUL,ADCY8,GNG5,GNGT2,GNGT1,GPHN,GLS2,GNAI1,GABRA1,GABARAPL2,PRKACB,ADCY7,GNG13,GAD1,ADCY3,GABRB3,PRKACA,GABRD,GNG2,ADCY9,ADCY6,SLC38A3,PRKACG,GABARAP,GNB5,GABBR2,GNAI2,SLC38A2,GABRR2,GNB4,GLS,ABAT,PRKCG,GNG7,SLC6A11,GABARAPL1,GABRA4,TRAK2,ADCY5,SRC,GNAI3,GNG10,PRKCA,GNB3,SLC38A1,SLC32A1,SLC6A13,KCNJ6,CACNA1D,GABRA6,GABRG1,GABRB1,GABRP,ADCY1,GNG8,SLC6A1
ko00120	Primary bile acid biosynthesis	0.376230559313707	-0.977553133852091	17	16	0.00253968253968254	6300	7161	10858,6718,8309,1593,570,9023,23600,10005,1109,1581,1582,80270,6342,3295,51302,9420	CYP46A1,AKR1D1,ACOX2,CYP27A1,BAAT,CH25H,AMACR,ACOT8,AKR1C4,CYP7A1,CYP8B1,HSD3B7,SCP2,HSD17B4,CYP39A1,CYP7B1
hsa00120	Primary bile acid biosynthesis	0.376230559313707	-0.977553133852091	17	16	0.00253968253968254	6300	7161	1582,80270,1581,9420,6342,3295,51302,1593,570,9023,10858,6718,8309,1109,10005,23600	CYP8B1,HSD3B7,CYP7A1,CYP7B1,SCP2,HSD17B4,CYP39A1,CYP27A1,BAAT,CH25H,CYP46A1,AKR1D1,ACOX2,AKR1C4,ACOT8,AMACR
hsa02010	ABC transporters	0.376789169437457	-0.976069480224197	44	40	0.00634920634920635	6300	7161	9429,8714,89845,23456,23457,10057,10257,4363,21,1244,85320,5243,10349,10347,19,23461,64240,10351,5826,10058,6890,10350,10060,6833,64241,23460,11194,5825,340273,94160,26154,9619,1080,6891,8647,154664,5244,64137,225,24	ABCG2,ABCC3,ABCC10,ABCB10,ABCB9,ABCC5,ABCC4,ABCC1,ABCA3,ABCC2,ABCC11,ABCB1,ABCA10,ABCA7,ABCA1,ABCA5,ABCG5,ABCA8,ABCD4,ABCB6,TAP1,ABCA9,ABCC9,ABCC8,ABCG8,ABCA6,ABCB8,ABCD3,ABCB5,ABCC12,ABCA12,ABCG1,CFTR,TAP2,ABCB11,ABCA13,ABCB4,ABCG4,ABCD2,ABCA4
ko02010	ABC transporters	0.376789169437457	-0.976069480224197	44	40	0.00634920634920635	6300	7161	225,64137,154664,5244,8647,6891,24,26154,1080,9619,11194,94160,340273,5825,10058,5826,10351,23461,64240,23460,64241,6833,10060,10350,6890,85320,1244,19,10347,10349,5243,10257,21,4363,89845,23456,9429,8714,10057,23457	ABCD2,ABCG4,ABCA13,ABCB4,ABCB11,TAP2,ABCA4,ABCA12,CFTR,ABCG1,ABCB8,ABCC12,ABCB5,ABCD3,ABCB6,ABCD4,ABCA8,ABCA5,ABCG5,ABCA6,ABCG8,ABCC8,ABCC9,ABCA9,TAP1,ABCC11,ABCC2,ABCA1,ABCA7,ABCA10,ABCB1,ABCC4,ABCA3,ABCC1,ABCC10,ABCB10,ABCG2,ABCC3,ABCC5,ABCB9
ko00970	Aminoacyl-tRNA biosynthesis	0.376789169437457	-0.976069480224197	44	40	0.00634920634920635	6300	7161	5917,10056,6301,57505,4677,833,5188,25973,79587,2058,7453,7407,23438,51067,2617,2193,55699,283459,80222,4141,3376,8565,23395,51091,10667,10352,124454,123263,3735,6897,92935,16,54938,79731,51520,57176,5859,1615,57038,118672	RARS1,FARSB,SARS1,AARS2,NARS1,CARS1,GATB,PARS2,CARS2,EPRS1,WARS1,VARS1,HARS2,YARS2,GARS1,FARSA,IARS2,GATC,TARS2,MARS1,IARS1,YARS1,LARS2,SEPSECS,FARS2,WARS2,EARS2,MTFMT,KARS1,TARS1,MARS2,AARS1,SARS2,NARS2,LARS1,VARS2,QARS1,DARS1,RARS2,PSTK
hsa00970	Aminoacyl-tRNA biosynthesis	0.376789169437457	-0.976069480224197	44	40	0.00634920634920635	6300	7161	1615,57038,118672,16,54938,5859,79731,57176,51520,10352,51091,10667,123263,124454,3735,92935,6897,55699,80222,283459,4141,23395,3376,8565,79587,7453,2058,7407,23438,2193,2617,51067,5188,25973,57505,4677,833,5917,10056,6301	DARS1,RARS2,PSTK,AARS1,SARS2,QARS1,NARS2,VARS2,LARS1,WARS2,SEPSECS,FARS2,MTFMT,EARS2,KARS1,MARS2,TARS1,IARS2,TARS2,GATC,MARS1,LARS2,IARS1,YARS1,CARS2,WARS1,EPRS1,VARS1,HARS2,FARSA,GARS1,YARS2,GATB,PARS2,AARS2,NARS1,CARS1,RARS1,FARSB,SARS1
ko04622	RIG-I-like receptor signaling pathway	0.383570893538578	-0.95823081596695	70	63	0.01	6300	7161	79132,8717,23586,3592,3593,3452,5601,4790,3442,3443,843,10010,340061,4214,3551,1432,9140,9636,338376,9474,9641,5602,26007,8772,5603,3439,64343,5599,29110,79671,3665,5970,3441,3456,3449,6300,9755,54941,841,4792,56832,4793,57506,3445,3448,3440,80143,3661,3467,3627,8737,7124,7189,5600,5300,1147,6885,3576,7187,1540,3444,64135,7706	DHX58,TRADD,RIGI,IL12A,IL12B,IFNA21,MAPK9,NFKB1,IFNA5,IFNA6,CASP10,TANK,STING1,MAP3K1,IKBKB,MAPK14,ATG12,ISG15,IFNE,ATG5,IKBKE,MAPK10,TKFC,FADD,MAPK13,IFNA1,AZI2,MAPK8,TBK1,NLRX1,IRF7,RELA,IFNA4,IFNB1,IFNA16,MAPK12,TBKBP1,RNF125,CASP8,NFKBIA,IFNK,NFKBIB,MAVS,IFNA8,IFNA14,IFNA2,SIKE1,IRF3,IFNW1,CXCL10,RIPK1,TNF,TRAF6,MAPK11,PIN1,CHUK,MAP3K7,CXCL8,TRAF3,CYLD,IFNA7,IFIH1,TRIM25
hsa04622	RIG-I-like receptor signaling pathway	0.383570893538578	-0.95823081596695	70	63	0.01	6300	7161	3441,3456,5970,3665,79671,6300,3449,54941,9755,338376,9636,9140,3551,1432,5599,64343,29110,3439,26007,5602,8772,5603,9474,9641,843,3442,3443,4214,10010,340061,23586,8717,79132,5601,4790,3592,3452,3593,3576,5300,6885,1147,64135,3444,7706,7187,1540,7189,7124,5600,3661,80143,3445,3440,3448,8737,3627,3467,4792,56832,57506,4793,841	IFNA4,IFNB1,RELA,IRF7,NLRX1,MAPK12,IFNA16,RNF125,TBKBP1,IFNE,ISG15,ATG12,IKBKB,MAPK14,MAPK8,AZI2,TBK1,IFNA1,TKFC,MAPK10,FADD,MAPK13,ATG5,IKBKE,CASP10,IFNA5,IFNA6,MAP3K1,TANK,STING1,RIGI,TRADD,DHX58,MAPK9,NFKB1,IL12A,IFNA21,IL12B,CXCL8,PIN1,MAP3K7,CHUK,IFIH1,IFNA7,TRIM25,TRAF3,CYLD,TRAF6,TNF,MAPK11,IRF3,SIKE1,IFNA8,IFNA2,IFNA14,RIPK1,CXCL10,IFNW1,NFKBIA,IFNK,MAVS,NFKBIB,CASP8
hsa04920	Adipocytokine signaling pathway	0.400395819499567	-0.915301672405849	69	62	0.00984126984126984	6300	7161	948,10645,2475,3953,3952,2180,5970,51094,181,5599,8660,5565,5602,9021,4794,5465,3551,6517,6774,5443,10891,6258,3717,23305,6513,5601,53632,4790,1374,51422,5105,207,8717,5564,9370,7133,7132,10000,2538,51703,5588,208,4852,79602,1147,5563,5781,5562,6256,23205,7124,5571,6794,81616,92579,126129,2181,4792,4793,57818,3667,32	CD36,CAMKK2,MTOR,LEPR,LEP,ACSL1,RELA,ADIPOR1,AGRP,MAPK8,IRS2,PRKAB2,MAPK10,SOCS3,NFKBIE,PPARA,IKBKB,SLC2A4,STAT3,POMC,PPARGC1A,RXRG,JAK2,ACSL6,SLC2A1,MAPK9,PRKAG3,NFKB1,CPT1A,PRKAG2,PCK1,AKT1,TRADD,PRKAB1,ADIPOQ,TNFRSF1B,TNFRSF1A,AKT3,G6PC1,ACSL5,PRKCQ,AKT2,NPY,ADIPOR2,CHUK,PRKAA2,PTPN11,PRKAA1,RXRA,ACSBG1,TNF,PRKAG1,STK11,ACSBG2,G6PC3,CPT1C,ACSL3,NFKBIA,NFKBIB,G6PC2,IRS1,ACACB
ko04920	Adipocytokine signaling pathway	0.400395819499567	-0.915301672405849	69	62	0.00984126984126984	6300	7161	10000,7132,7133,2538,51703,5588,208,4852,79602,1147,5781,5562,5563,6256,23205,5571,7124,6794,81616,92579,126129,2181,4793,4792,57818,32,3667,948,10645,2475,3952,2180,5970,3953,181,51094,8660,5599,5565,5602,9021,4794,6517,5465,3551,5443,6774,10891,6258,3717,23305,6513,4790,53632,5601,1374,5105,51422,8717,207,9370,5564	AKT3,TNFRSF1A,TNFRSF1B,G6PC1,ACSL5,PRKCQ,AKT2,NPY,ADIPOR2,CHUK,PTPN11,PRKAA1,PRKAA2,RXRA,ACSBG1,PRKAG1,TNF,STK11,ACSBG2,G6PC3,CPT1C,ACSL3,NFKBIB,NFKBIA,G6PC2,ACACB,IRS1,CD36,CAMKK2,MTOR,LEP,ACSL1,RELA,LEPR,AGRP,ADIPOR1,IRS2,MAPK8,PRKAB2,MAPK10,SOCS3,NFKBIE,SLC2A4,PPARA,IKBKB,POMC,STAT3,PPARGC1A,RXRG,JAK2,ACSL6,SLC2A1,NFKB1,PRKAG3,MAPK9,CPT1A,PCK1,PRKAG2,TRADD,AKT1,ADIPOQ,PRKAB1
ko00592	alpha-Linolenic acid metabolism	0.407048415738609	-0.898823143025715	25	23	0.00365079365079365	6300	7161	283748,84647,51,81579,30,255189,30814,64600,5322,5320,5319,151056,8605,8310,391013,11145,123745,26279,100137049,8398,9415,50487,5321	PLA2G4D,PLA2G12B,ACOX1,PLA2G12A,ACAA1,PLA2G4F,PLA2G2E,PLA2G2F,PLA2G5,PLA2G2A,PLA2G1B,PLB1,PLA2G4C,ACOX3,PLA2G2C,PLAAT3,PLA2G4E,PLA2G2D,PLA2G4B,PLA2G6,FADS2,PLA2G3,PLA2G4A
hsa00592	alpha-Linolenic acid metabolism	0.407048415738609	-0.898823143025715	25	23	0.00365079365079365	6300	7161	30,81579,51,84647,283748,8605,151056,5319,5320,5322,64600,30814,255189,123745,11145,391013,8310,5321,50487,9415,8398,100137049,26279	ACAA1,PLA2G12A,ACOX1,PLA2G12B,PLA2G4D,PLA2G4C,PLB1,PLA2G1B,PLA2G2A,PLA2G5,PLA2G2F,PLA2G2E,PLA2G4F,PLA2G4E,PLAAT3,PLA2G2C,ACOX3,PLA2G4A,PLA2G3,FADS2,PLA2G6,PLA2G4B,PLA2G2D
M00691	DNA damage-induced cell cycle checkpoints	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	993,11200,1111,995,994,545,472	CDC25A,CHEK2,CHEK1,CDC25C,CDC25B,ATR,ATM
hsa_M00396	Lsm 2-8 complex	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	23658,51690,57819,11157,51691,25804,27258	LSM5,LSM7,LSM2,LSM6,LSM8,LSM4,LSM3
hsa_M00549	Nucleotide sugar biosynthesis, glucose => UDP-glucose	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	2645,3101,80201,3098,5236,7360,3099	GCK,HK3,HKDC1,HK1,PGM1,UGP2,HK2
hsa_M00047	Creatine pathway	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	1159,1160,2628,2593,1152,548596,1158	CKMT1B,CKMT2,GATM,GAMT,CKB,CKMT1A,CKM
hsa_M00691	DNA damage-induced cell cycle checkpoints	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	11200,1111,995,545,993,994,472	CHEK2,CHEK1,CDC25C,ATR,CDC25A,CDC25B,ATM
hsa_M00072	N-glycosylation by oligosaccharyltransferase	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	1603,6185,1650,7991,201595,3703,6184	DAD1,RPN2,DDOST,TUSC3,STT3B,STT3A,RPN1
M00396	Lsm 2-8 complex	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	11157,51691,25804,27258,51690,57819,23658	LSM6,LSM8,LSM4,LSM3,LSM7,LSM2,LSM5
M00072	N-glycosylation by oligosaccharyltransferase	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	201595,3703,6184,1603,6185,1650,7991	STT3B,STT3A,RPN1,DAD1,RPN2,DDOST,TUSC3
hsa_M00397	Lsm 1-7 complex	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	27257,23658,11157,27258,25804,57819,51690	LSM1,LSM5,LSM6,LSM3,LSM4,LSM2,LSM7
M00549	Nucleotide sugar biosynthesis, glucose => UDP-glucose	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	3098,80201,2645,3101,7360,5236,3099	HK1,HKDC1,GCK,HK3,UGP2,PGM1,HK2
M00047	Creatine pathway	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	1160,2593,2628,1152,1158,548596,1159	CKMT2,GAMT,GATM,CKB,CKM,CKMT1A,CKMT1B
M00397	Lsm 1-7 complex	0.407749990942553	-0.897101059694251	7	7	0.00111111111111111	6300	7161	11157,27258,25804,57819,51690,27257,23658	LSM6,LSM3,LSM4,LSM2,LSM7,LSM1,LSM5
ko03018	RNA degradation	0.410939755996876	-0.889308654312693	77	69	0.010952380952381	6300	7161	11044,131870,10766,3329,3313,27258,56915,23019,23016,22803,7832,9125,255967,4849,10950,54464,84186,80153,29883,10438,23644,118460,5042,11340,22894,23517,51691,5211,51690,694,5394,170506,55802,80336,64282,25804,9652,246175,196513,57819,26986,28960,54766,1656,5393,2027,27257,115752,2026,2023,23658,51010,23404,219988,10140,167227,11157,9337,10200,57472,5073,4850,4848,5214,87178,25904,8761,132430,9924	TENT4A,NUDT16,TOB2,HSPD1,HSPA9,LSM3,EXOSC5,CNOT1,EXOSC7,XRN2,BTG2,CNOT9,PAN3,CNOT3,BTG3,XRN1,ZCCHC7,EDC3,CNOT7,C1D,EDC4,EXOSC6,PABPC3,EXOSC8,DIS3,MTREX,LSM8,PFKL,LSM7,BTG1,EXOSC10,DHX36,DCP1A,PABPC1L,TENT4B,LSM4,SKIC3,CNOT6L,DCP1B,LSM2,PABPC1,DCPS,BTG4,DDX6,EXOSC9,ENO3,LSM1,DIS3L,ENO2,ENO1,LSM5,EXOSC3,EXOSC2,PATL1,TOB1,DCP2,LSM6,CNOT8,MPHOSPH6,CNOT6,PARN,CNOT4,CNOT2,PFKP,PNPT1,CNOT10,PABPC4,PABPC4L,PAN2
hsa03018	RNA degradation	0.410939755996876	-0.889308654312693	77	69	0.010952380952381	6300	7161	2026,115752,27257,2027,1656,54766,5393,28960,26986,57819,9652,246175,196513,25804,64282,80336,55802,170506,9924,132430,87178,25904,8761,5214,4848,10200,4850,5073,57472,167227,11157,9337,219988,10140,23404,23658,51010,2023,10950,4849,255967,9125,7832,23016,22803,23019,56915,27258,3313,3329,10766,131870,11044,5394,51690,5211,694,22894,23517,51691,5042,11340,118460,23644,10438,29883,84186,80153,54464	ENO2,DIS3L,LSM1,ENO3,DDX6,BTG4,EXOSC9,DCPS,PABPC1,LSM2,SKIC3,CNOT6L,DCP1B,LSM4,TENT4B,PABPC1L,DCP1A,DHX36,PAN2,PABPC4L,PNPT1,CNOT10,PABPC4,PFKP,CNOT2,MPHOSPH6,CNOT4,PARN,CNOT6,DCP2,LSM6,CNOT8,PATL1,TOB1,EXOSC2,LSM5,EXOSC3,ENO1,BTG3,CNOT3,PAN3,CNOT9,BTG2,EXOSC7,XRN2,CNOT1,EXOSC5,LSM3,HSPA9,HSPD1,TOB2,NUDT16,TENT4A,EXOSC10,LSM7,PFKL,BTG1,DIS3,MTREX,LSM8,PABPC3,EXOSC8,EXOSC6,EDC4,C1D,CNOT7,ZCCHC7,EDC3,XRN1
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	0.416512417430038	-0.875839004062066	145	129	0.0204761904761905	6300	7161	79602,1345,4702,208,4714,4728,4720,1329,10000,836,7124,1327,10018,5571,4698,6256,1350,5563,5562,4715,5313,4709,3630,22877,54205,5290,6389,6392,55967,4217,4707,841,126328,4708,4700,4711,1965,3953,3952,4722,4723,7040,4716,9451,8660,2931,1337,4697,4729,4296,468,581,5293,6720,374291,3552,51422,3553,207,6390,3570,341947,10975,1346,1339,355,5601,4790,1340,3576,9377,7385,4725,7132,51085,7494,6391,4695,4731,356,4724,4710,7384,4718,2081,5295,3725,3667,3569,4706,51094,4705,10062,5970,5291,4719,5296,5879,3551,5465,83737,4717,5602,9021,8503,9167,5599,840,5565,1050,4712,440567,29796,4696,7381,4704,170712,998,9370,5564,4726,1347,7386,2932,56901,1351,51079,53632,3643	ADIPOR2,COX6C,NDUFA8,AKT2,NDUFB8,NDUFS8,NDUFS2,COX5B,AKT3,CASP3,TNF,COX4I1,BCL2L11,PRKAG1,NDUFA5,RXRA,COX7C,PRKAA2,PRKAA1,NDUFB9,PKLR,NDUFB3,INS,MLXIP,CYCS,PIK3CA,SDHA,SDHD,NDUFA12,MAP3K5,NDUFB1,CASP8,NDUFA11,NDUFB2,NDUFA6,NDUFB5,EIF2S1,LEPR,LEP,NDUFS3,NDUFV1,TGFB1,NDUFB10,EIF2AK3,IRS2,GSK3A,COX6A1,NDUFA4,NDUFV2,MAP3K11,ATF4,BAX,PIK3CD,SREBF1,NDUFS7,IL1A,PRKAG2,IL1B,AKT1,SDHB,IL6R,COX8C,UQCR11,COX7A1,COX6A2,FAS,MAPK9,NFKB1,COX6B1,CXCL8,COX5A,UQCRC2,NDUFS5,TNFRSF1A,MLXIPL,XBP1,SDHC,NDUFA2,NDUFV3,FASLG,NDUFS4,NDUFB4,UQCRC1,NDUFC2,ERN1,PIK3R1,JUN,IRS1,IL6,NDUFAB1,ADIPOR1,NDUFA10,NR1H3,RELA,PIK3CB,NDUFS1,PIK3R2,RAC1,IKBKB,PPARA,ITCH,NDUFC1,MAPK10,SOCS3,PIK3R3,COX7A2L,MAPK8,CASP7,PRKAB2,CEBPA,NDUFB6,UQCRHL,UQCR10,NDUFA3,UQCRB,NDUFA9,COX7B2,CDC42,ADIPOQ,PRKAB1,NDUFS6,COX7A2,UQCRFS1,GSK3B,NDUFA4L2,COX8A,NDUFA13,PRKAG3,INSR
ko04932	Non-alcoholic fatty liver disease (NAFLD)	0.416512417430038	-0.875839004062066	145	129	0.0204761904761905	6300	7161	6720,207,6390,3553,3552,374291,51422,10975,341947,3570,4790,5601,1346,1339,355,1337,4296,4729,4697,581,468,5293,7040,4716,2931,8660,9451,4700,4708,4711,3952,3953,1965,4723,4722,4707,4217,55967,6392,841,126328,5313,4715,22877,3630,4709,5290,6389,54205,4698,5571,10018,7124,1327,6256,1350,5562,5563,4702,1345,79602,208,4714,10000,1329,836,4728,4720,4726,5564,9370,998,170712,1347,7386,56901,2932,3643,53632,51079,1351,4712,1050,29796,440567,4704,7381,4696,4717,83737,3551,5465,5879,5296,9167,9021,8503,5602,5565,840,5599,10062,4705,51094,5970,5291,4719,3667,3725,3569,4706,4724,4718,4710,7384,2081,5295,4695,6391,7494,51085,4731,356,1340,9377,3576,7385,7132,4725	SREBF1,AKT1,SDHB,IL1B,IL1A,NDUFS7,PRKAG2,UQCR11,COX8C,IL6R,NFKB1,MAPK9,COX7A1,COX6A2,FAS,COX6A1,MAP3K11,NDUFV2,NDUFA4,BAX,ATF4,PIK3CD,TGFB1,NDUFB10,GSK3A,IRS2,EIF2AK3,NDUFA6,NDUFB2,NDUFB5,LEP,LEPR,EIF2S1,NDUFV1,NDUFS3,NDUFB1,MAP3K5,NDUFA12,SDHD,CASP8,NDUFA11,PKLR,NDUFB9,MLXIP,INS,NDUFB3,PIK3CA,SDHA,CYCS,NDUFA5,PRKAG1,BCL2L11,TNF,COX4I1,RXRA,COX7C,PRKAA1,PRKAA2,NDUFA8,COX6C,ADIPOR2,AKT2,NDUFB8,AKT3,COX5B,CASP3,NDUFS8,NDUFS2,NDUFS6,PRKAB1,ADIPOQ,CDC42,COX7B2,COX7A2,UQCRFS1,NDUFA4L2,GSK3B,INSR,PRKAG3,NDUFA13,COX8A,NDUFB6,CEBPA,UQCR10,UQCRHL,NDUFA9,UQCRB,NDUFA3,NDUFC1,ITCH,IKBKB,PPARA,RAC1,PIK3R2,COX7A2L,SOCS3,PIK3R3,MAPK10,PRKAB2,CASP7,MAPK8,NR1H3,NDUFA10,ADIPOR1,RELA,PIK3CB,NDUFS1,IRS1,JUN,IL6,NDUFAB1,NDUFS4,NDUFC2,NDUFB4,UQCRC1,ERN1,PIK3R1,NDUFA2,SDHC,XBP1,MLXIPL,NDUFV3,FASLG,COX6B1,COX5A,CXCL8,UQCRC2,TNFRSF1A,NDUFS5
hsa00561	Glycerolipid metabolism	0.424807366834937	-0.856119467314623	59	53	0.00841269841269841	6300	7161	219,116255,8513,1608,55750,8612,8613,154141,64900,8526,56894,129642,8527,137964,132158,56895,84803,1056,253558,231,346606,84649,55326,8611,3990,5408,9388,9663,217,5406,57678,5407,2712,80339,9162,57016,26007,223,1609,10327,80168,8525,501,150763,160851,1606,11343,57104,224,23175,1607,119548,4023	ALDH1B1,MOGAT1,LIPF,DGKG,AGK,PLPP2,PLPP3,MBOAT1,LPIN3,DGKE,AGPAT3,MBOAT2,DGKD,GPAT4,GLYCTK,AGPAT4,GPAT3,CEL,LCLAT1,AKR1B1,MOGAT3,DGAT2,AGPAT5,PLPP1,LIPC,PNLIPRP2,LIPG,LPIN2,ALDH2,PNLIP,GPAM,PNLIPRP1,GK2,PNPLA3,DGKI,AKR1B10,TKFC,ALDH9A1,DGKQ,AKR1A1,MOGAT2,DGKZ,ALDH7A1,GPAT2,DGKH,DGKA,MGLL,PNPLA2,ALDH3A2,LPIN1,DGKB,PNLIPRP3,LPL
ko00561	Glycerolipid metabolism	0.424807366834937	-0.856119467314623	59	53	0.00841269841269841	6300	7161	5406,217,5407,57678,57016,9162,80339,2712,1609,223,26007,501,150763,10327,80168,8525,23175,57104,224,160851,1606,11343,119548,4023,1607,8513,116255,219,1608,64900,8526,154141,8612,8613,55750,8527,129642,56894,84803,1056,56895,137964,132158,84649,231,346606,253558,8611,3990,55326,9388,9663,5408	PNLIP,ALDH2,PNLIPRP1,GPAM,AKR1B10,DGKI,PNPLA3,GK2,DGKQ,ALDH9A1,TKFC,ALDH7A1,GPAT2,AKR1A1,MOGAT2,DGKZ,LPIN1,PNPLA2,ALDH3A2,DGKH,DGKA,MGLL,PNLIPRP3,LPL,DGKB,LIPF,MOGAT1,ALDH1B1,DGKG,LPIN3,DGKE,MBOAT1,PLPP2,PLPP3,AGK,DGKD,MBOAT2,AGPAT3,GPAT3,CEL,AGPAT4,GPAT4,GLYCTK,DGAT2,AKR1B1,MOGAT3,LCLAT1,PLPP1,LIPC,AGPAT5,LIPG,LPIN2,PNLIPRP2
ko00051	Fructose and mannose metabolism	0.427112279016321	-0.850708351802441	33	30	0.00476190476190476	6300	7161	2203,7264,57016,3099,4351,6652,5372,80201,5373,5209,5210,226,197258,3098,3795,8789,29926,55556,3101,29925,2762,8790,5214,229,26007,57103,231,7167,5211,5208	FBP1,GFUS,AKR1B10,HK2,MPI,SORD,PMM1,HKDC1,PMM2,PFKFB3,PFKFB4,ALDOA,FCSK,HK1,KHK,FBP2,GMPPA,ENOSF1,HK3,GMPPB,GMDS,FPGT,PFKP,ALDOB,TKFC,TIGAR,AKR1B1,TPI1,PFKL,PFKFB2
hsa00051	Fructose and mannose metabolism	0.427112279016321	-0.850708351802441	33	30	0.00476190476190476	6300	7161	3101,29925,2762,5214,8790,26007,229,57103,5211,5208,7167,231,3098,3795,8789,29926,55556,5373,80201,5372,5209,5210,226,197258,2203,7264,57016,3099,4351,6652	HK3,GMPPB,GMDS,PFKP,FPGT,TKFC,ALDOB,TIGAR,PFKL,PFKFB2,TPI1,AKR1B1,HK1,KHK,FBP2,GMPPA,ENOSF1,PMM2,HKDC1,PMM1,PFKFB3,PFKFB4,ALDOA,FCSK,FBP1,GFUS,AKR1B10,HK2,MPI,SORD
hsa04657	IL-17 signaling pathway	0.428528568604872	-0.847397871976828	93	83	0.0131746031746032	6300	7161	6426,4790,5601,4314,7188,2932,6361,53342,8717,3553,6372,1437,132014,112744,29110,84818,5599,8061,29761,9641,23765,5603,8772,5602,6280,6354,1432,3551,27189,3565,4318,55540,2353,6279,5596,2920,6300,5970,3596,3727,5597,3320,7128,3326,4792,841,3458,4322,3569,727897,5598,5595,3725,6364,3627,2921,3567,3934,6278,2354,27190,51433,23118,5743,5600,5594,6374,6347,7189,3605,4312,7124,836,10758,7187,2919,3576,6356,225689,1147,6885,1994,1051	SRSF1,NFKB1,MAPK9,MMP3,TRAF5,GSK3B,CCL17,IL17D,TRADD,IL1B,CXCL6,CSF2,IL17RE,IL17F,TBK1,IL17RC,MAPK8,FOSL1,USP25,IKBKE,IL17RA,MAPK13,FADD,MAPK10,S100A9,CCL7,MAPK14,IKBKB,IL17C,IL4,MMP9,IL17RB,FOS,S100A8,MAPK4,CXCL2,MAPK12,RELA,IL13,JUND,MAPK6,HSP90AA1,TNFAIP3,HSP90AB1,NFKBIA,CASP8,IFNG,MMP13,IL6,MUC5B,MAPK7,MAPK3,JUN,CCL20,CXCL10,CXCL3,IL5,LCN2,S100A7,FOSB,IL17B,ANAPC5,TAB2,PTGS2,MAPK11,MAPK1,CXCL5,CCL2,TRAF6,IL17A,MMP1,TNF,CASP3,TRAF3IP2,TRAF3,CXCL1,CXCL8,CCL11,MAPK15,CHUK,MAP3K7,ELAVL1,CEBPB
ko04657	IL-17 signaling pathway	0.428528568604872	-0.847397871976828	93	83	0.0131746031746032	6300	7161	132014,112744,1437,53342,6361,2932,5601,4314,4790,6426,7188,8717,3553,6372,5596,6300,2920,2353,55540,6279,3727,5597,3320,5970,3596,23765,29761,9641,5602,8772,5603,5599,8061,84818,29110,3551,27189,1432,4318,3565,6280,6354,3627,2921,2354,3567,3934,6278,4322,3458,841,3569,3326,7128,4792,6364,727897,3725,5595,5598,7187,10758,2919,836,1147,6885,1994,1051,225689,6356,3576,5594,5600,6374,27190,51433,5743,23118,4312,7124,6347,3605,7189	IL17RE,IL17F,CSF2,IL17D,CCL17,GSK3B,MAPK9,MMP3,NFKB1,SRSF1,TRAF5,TRADD,IL1B,CXCL6,MAPK4,MAPK12,CXCL2,FOS,IL17RB,S100A8,JUND,MAPK6,HSP90AA1,RELA,IL13,IL17RA,USP25,IKBKE,MAPK10,FADD,MAPK13,MAPK8,FOSL1,IL17RC,TBK1,IKBKB,IL17C,MAPK14,MMP9,IL4,S100A9,CCL7,CXCL10,CXCL3,FOSB,IL5,LCN2,S100A7,MMP13,IFNG,CASP8,IL6,HSP90AB1,TNFAIP3,NFKBIA,CCL20,MUC5B,JUN,MAPK3,MAPK7,TRAF3,TRAF3IP2,CXCL1,CASP3,CHUK,MAP3K7,ELAVL1,CEBPB,MAPK15,CCL11,CXCL8,MAPK1,MAPK11,CXCL5,IL17B,ANAPC5,PTGS2,TAB2,MMP1,TNF,CCL2,IL17A,TRAF6
hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.435744772077857	-0.83069859218041	24	22	0.00349206349206349	6300	7161	9394,9956,2134,2132,26229,11285,64579,64131,2135,9957,2131,266722,3340,9953,9955,9348,9653,126792,26035,2137,64132,222537	HS6ST1,HS3ST2,EXTL1,EXT2,B3GAT3,B4GALT7,NDST4,XYLT1,EXTL2,HS3ST1,EXT1,HS6ST3,NDST1,HS3ST3B1,HS3ST3A1,NDST3,HS2ST1,B3GALT6,GLCE,EXTL3,XYLT2,HS3ST5
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.435744772077857	-0.83069859218041	24	22	0.00349206349206349	6300	7161	126792,3340,9348,9653,266722,9957,64579,64131,2132,11285,2135,9956,26035,2137,64132,222537,9953,9955,2131,26229,2134,9394	B3GALT6,NDST1,NDST3,HS2ST1,HS6ST3,HS3ST1,NDST4,XYLT1,EXT2,B4GALT7,EXTL2,HS3ST2,GLCE,EXTL3,XYLT2,HS3ST5,HS3ST3B1,HS3ST3A1,EXT1,B3GAT3,EXTL1,HS6ST1
ko05222	Small cell lung cancer	0.435946124157733	-0.83023661171388	84	75	0.0119047619047619	6300	7161	5290,5295,54205,3673,5747,3655,1164,596,4792,5728,3911,3908,7157,1285,10000,7187,208,1147,6502,4149,2335,5743,3688,3685,1284,22798,6256,7189,842,3912,1870,2272,3913,898,1027,5293,284217,329,3675,6258,9134,1030,79444,9063,4790,1021,112401,7185,3914,7188,598,207,5925,1282,1871,10319,317,5291,1286,330,5970,1017,4609,3674,595,3909,5915,1019,8503,3915,3910,3551,3918,1869,5296	PIK3CA,PIK3R1,CYCS,ITGA2,PTK2,ITGA6,CKS2,BCL2,NFKBIA,PTEN,LAMA5,LAMA2,TP53,COL4A3,AKT3,TRAF3,AKT2,CHUK,SKP2,MAX,FN1,PTGS2,ITGB1,ITGAV,COL4A2,LAMB4,RXRA,TRAF6,CASP9,LAMB1,E2F2,FHIT,LAMB2,CCNE1,CDKN1B,PIK3CD,LAMA1,BIRC2,ITGA3,RXRG,CCNE2,CDKN2B,BIRC7,PIAS2,NFKB1,CDK6,BIRC8,TRAF1,LAMB3,TRAF5,BCL2L1,AKT1,RB1,COL4A1,E2F3,LAMC3,APAF1,PIK3CB,COL4A4,BIRC3,RELA,CDK2,MYC,ITGA2B,CCND1,LAMA3,RARB,CDK4,PIK3R3,LAMC1,LAMA4,IKBKB,LAMC2,E2F1,PIK3R2
hsa05222	Small cell lung cancer	0.435946124157733	-0.83023661171388	84	75	0.0119047619047619	6300	7161	595,1017,4609,3674,5970,330,1286,5291,317,5296,3915,3910,1869,3551,3918,1019,8503,5915,3909,79444,9063,6258,9134,1030,3675,329,5293,1027,284217,898,10319,5925,1282,1871,207,7185,3914,112401,598,7188,4790,1021,2335,6502,4149,1147,208,7187,10000,3912,1870,3913,2272,842,7189,6256,1284,22798,3688,3685,5743,3655,596,1164,3673,5747,5290,5295,54205,3911,3908,7157,1285,5728,4792	CCND1,CDK2,MYC,ITGA2B,RELA,BIRC3,COL4A4,PIK3CB,APAF1,PIK3R2,LAMC1,LAMA4,E2F1,IKBKB,LAMC2,CDK4,PIK3R3,RARB,LAMA3,BIRC7,PIAS2,RXRG,CCNE2,CDKN2B,ITGA3,BIRC2,PIK3CD,CDKN1B,LAMA1,CCNE1,LAMC3,RB1,COL4A1,E2F3,AKT1,TRAF1,LAMB3,BIRC8,BCL2L1,TRAF5,NFKB1,CDK6,FN1,SKP2,MAX,CHUK,AKT2,TRAF3,AKT3,LAMB1,E2F2,LAMB2,FHIT,CASP9,TRAF6,RXRA,COL4A2,LAMB4,ITGB1,ITGAV,PTGS2,ITGA6,BCL2,CKS2,ITGA2,PTK2,PIK3CA,PIK3R1,CYCS,LAMA5,LAMA2,TP53,COL4A3,PTEN,NFKBIA
hsa04975	Fat digestion and absorption	0.44182993133358	-0.816830241686201	41	37	0.00587301587301587	6300	7161	2168,81579,39,1056,80168,29881,84647,346606,84649,5322,5320,948,5319,8611,338,2806,5408,30814,64600,10999,8513,949,337,1208,19,5406,2169,335,64240,5407,64241,391013,8612,8613,50487,26279,4547	FABP1,PLA2G12A,ACAT2,CEL,MOGAT2,NPC1L1,PLA2G12B,MOGAT3,DGAT2,PLA2G5,PLA2G2A,CD36,PLA2G1B,PLPP1,APOB,GOT2,PNLIPRP2,PLA2G2E,PLA2G2F,SLC27A4,LIPF,SCARB1,APOA4,CLPS,ABCA1,PNLIP,FABP2,APOA1,ABCG5,PNLIPRP1,ABCG8,PLA2G2C,PLPP2,PLPP3,PLA2G3,PLA2G2D,MTTP
ko04975	Fat digestion and absorption	0.44182993133358	-0.816830241686201	41	37	0.00587301587301587	6300	7161	50487,8612,8613,26279,4547,337,1208,19,5406,10999,8513,949,5407,64241,391013,335,2169,64240,338,8611,5322,948,5320,5319,64600,2806,5408,30814,1056,2168,81579,39,346606,84647,84649,80168,29881	PLA2G3,PLPP2,PLPP3,PLA2G2D,MTTP,APOA4,CLPS,ABCA1,PNLIP,SLC27A4,LIPF,SCARB1,PNLIPRP1,ABCG8,PLA2G2C,APOA1,FABP2,ABCG5,APOB,PLPP1,PLA2G5,CD36,PLA2G2A,PLA2G1B,PLA2G2F,GOT2,PNLIPRP2,PLA2G2E,CEL,FABP1,PLA2G12A,ACAT2,MOGAT3,PLA2G12B,DGAT2,MOGAT2,NPC1L1
ko04914	Progesterone-mediated oocyte maturation	0.443635343430129	-0.812752352581161	92	82	0.013015873015873	6300	7161	51343,107,890,3845,441272,5293,729597,2773,207,64682,111,29945,22849,6196,5601,9088,51529,388333,4085,387778,132864,1017,51434,8697,993,3320,995,5291,6300,673,5894,285955,994,80315,1432,2771,5296,5568,100310812,4342,5140,5347,5599,5241,8503,112,5602,5603,115,109,5566,5295,5290,3630,996,8900,113,5567,5595,5604,2770,983,114,3326,245711,64506,208,699,8379,3480,891,9133,10459,6195,10393,10000,108,3479,51433,5594,196883,5600	FZR1,ADCY1,CCNA2,KRAS,SPDYE3,PIK3CD,SPDYE6,GNAI3,AKT1,ANAPC1,ADCY5,ANAPC4,CPEB3,RPS6KA2,MAPK9,PKMYT1,ANAPC11,SPDYE4,MAD2L1,SPDYC,CPEB2,CDK2,ANAPC7,CDC23,CDC25A,HSP90AA1,CDC25C,PIK3CB,MAPK12,BRAF,RAF1,SPDYE1,CDC25B,CPEB4,MAPK14,GNAI2,PIK3R2,PRKACG,SPDYE2B,MOS,PDE3B,PLK1,MAPK8,PGR,PIK3R3,ADCY6,MAPK10,MAPK13,ADCY9,ADCY3,PRKACA,PIK3R1,PIK3CA,INS,CDC27,CCNA1,ADCY7,PRKACB,MAPK3,MAP2K1,GNAI1,CDK1,ADCY8,HSP90AB1,SPDYA,CPEB1,AKT2,BUB1,MAD1L1,IGF1R,CCNB1,CCNB2,MAD2L2,RPS6KA1,ANAPC10,AKT3,ADCY2,IGF1,ANAPC5,MAPK1,ADCY4,MAPK11
hsa04914	Progesterone-mediated oocyte maturation	0.443635343430129	-0.812752352581161	92	82	0.013015873015873	6300	7161	729597,2773,207,29945,22849,64682,111,9088,5601,6196,388333,51529,51343,890,3845,107,5293,441272,5894,285955,994,2771,5296,80315,1432,5140,5347,5599,5241,5568,100310812,4342,5602,5603,8503,112,1017,132864,4085,387778,8697,993,3320,51434,995,6300,673,5291,5604,5595,2770,983,3326,114,245711,115,5566,109,5295,5290,5567,113,996,3630,8900,108,51433,3479,5594,196883,5600,9133,891,64506,8379,208,699,3480,6195,10393,10459,10000	SPDYE6,GNAI3,AKT1,ANAPC4,CPEB3,ANAPC1,ADCY5,PKMYT1,MAPK9,RPS6KA2,SPDYE4,ANAPC11,FZR1,CCNA2,KRAS,ADCY1,PIK3CD,SPDYE3,RAF1,SPDYE1,CDC25B,GNAI2,PIK3R2,CPEB4,MAPK14,PDE3B,PLK1,MAPK8,PGR,PRKACG,SPDYE2B,MOS,MAPK10,MAPK13,PIK3R3,ADCY6,CDK2,CPEB2,MAD2L1,SPDYC,CDC23,CDC25A,HSP90AA1,ANAPC7,CDC25C,MAPK12,BRAF,PIK3CB,MAP2K1,MAPK3,GNAI1,CDK1,HSP90AB1,ADCY8,SPDYA,ADCY9,PRKACA,ADCY3,PIK3R1,PIK3CA,PRKACB,ADCY7,CDC27,INS,CCNA1,ADCY2,ANAPC5,IGF1,MAPK1,ADCY4,MAPK11,CCNB2,CCNB1,CPEB1,MAD1L1,AKT2,BUB1,IGF1R,RPS6KA1,ANAPC10,MAD2L2,AKT3
hsa05416	Viral myocarditis	0.443698046637018	-0.812611023047762	58	52	0.00825396825396825	6300	7161	8672,3908,1605,841,941,6443,2534,6442,857,5881,54205,3109,842,1604,60,3118,25,3106,3133,942,3107,836,3123,3122,3119,3689,3105,1981,3108,3111,6445,4625,27,1525,3117,3134,5879,3113,1982,5551,3112,3683,71,3135,595,940,3127,3383,958,4624,5880,6444	EIF4G3,LAMA2,DAG1,CASP8,CD80,SGCB,FYN,SGCA,CAV1,RAC3,CYCS,HLA-DMB,CASP9,CD55,ACTB,HLA-DQA2,ABL1,HLA-B,HLA-E,CD86,HLA-C,CASP3,HLA-DRB1,HLA-DRA,HLA-DQB1,ITGB2,HLA-A,EIF4G1,HLA-DMA,HLA-DOA,SGCG,MYH7,ABL2,CXADR,HLA-DQA1,HLA-F,RAC1,HLA-DPA1,EIF4G2,PRF1,HLA-DOB,ITGAL,ACTG1,HLA-G,CCND1,CD28,HLA-DRB5,ICAM1,CD40,MYH6,RAC2,SGCD
ko00604	Glycosphingolipid biosynthesis - ganglio series	0.446252911530602	-0.806869421471248	15	14	0.00222222222222222	6300	7161	2583,81849,27090,256435,30815,9197,6489,8869,29906,6483,3074,6482,2720,8705	B4GALNT1,ST6GALNAC5,ST6GALNAC4,ST6GALNAC3,ST6GALNAC6,SLC33A1,ST8SIA1,ST3GAL5,ST8SIA5,ST3GAL2,HEXB,ST3GAL1,GLB1,B3GALT4
hsa00604	Glycosphingolipid biosynthesis - ganglio series	0.446252911530602	-0.806869421471248	15	14	0.00222222222222222	6300	7161	8869,6489,8705,2720,3074,6482,6483,29906,30815,256435,2583,27090,81849,9197	ST3GAL5,ST8SIA1,B3GALT4,GLB1,HEXB,ST3GAL1,ST3GAL2,ST8SIA5,ST6GALNAC6,ST6GALNAC3,B4GALNT1,ST6GALNAC4,ST6GALNAC5,SLC33A1
ko00790	Folate biosynthesis	0.446252911530602	-0.806869421471248	15	14	0.00222222222222222	6300	7161	1719,5860,8836,10243,251,6697,250,4337,248,5805,4338,200895,2643,249	DHFR,QDPR,GGH,GPHN,ALPG,SPR,ALPP,MOCS1,ALPI,PTS,MOCS2,DHFR2,GCH1,ALPL
hsa00790	Folate biosynthesis	0.446252911530602	-0.806869421471248	15	14	0.00222222222222222	6300	7161	4338,2643,200895,249,5805,6697,251,4337,250,248,5860,1719,10243,8836	MOCS2,GCH1,DHFR2,ALPL,PTS,SPR,ALPG,MOCS1,ALPP,ALPI,QDPR,DHFR,GPHN,GGH
hsa_M00109	C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	1585,3291,1589,1584,1586,3290	CYP11B2,HSD11B2,CYP21A2,CYP11B1,CYP17A1,HSD11B1
M00058	Glycosaminoglycan biosynthesis, chondroitin sulfate backbone	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	22856,55454,54480,337876,79586,55790	CHSY1,CSGALNACT2,CHPF2,CHSY3,CHPF,CSGALNACT1
ko00750	Vitamin B6 metabolism	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	493911,57026,29968,316,8566,55163	PHOSPHO2,PDXP,PSAT1,AOX1,PDXK,PNPO
M00141	C1-unit interconversion, eukaryotes	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	441024,10797,6472,4522,6470,25902	MTHFD2L,MTHFD2,SHMT2,MTHFD1,SHMT1,MTHFD1L
M00048	Inosine monophosphate biosynthesis, PRPP + glutamine => IMP	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	10606,5198,2618,471,158,5471	PAICS,PFAS,GART,ATIC,ADSL,PPAT
hsa_M00048	Inosine monophosphate biosynthesis, PRPP + glutamine => IMP	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	2618,5198,10606,5471,158,471	GART,PFAS,PAICS,PPAT,ADSL,ATIC
M00284	Origin recognition complex	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	4998,23595,5001,23594,4999,5000	ORC1,ORC3,ORC5,ORC6,ORC2,ORC4
hsa00750	Vitamin B6 metabolism	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	493911,57026,316,29968,55163,8566	PHOSPHO2,PDXP,AOX1,PSAT1,PNPO,PDXK
hsa_M00284	Origin recognition complex	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	4998,23595,5001,23594,4999,5000	ORC1,ORC3,ORC5,ORC6,ORC2,ORC4
hsa_M00395	Decapping complex	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	80153,1656,167227,196513,55802,219988	EDC3,DDX6,DCP2,DCP1B,DCP1A,PATL1
M00109	C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	1585,3291,1589,1584,1586,3290	CYP11B2,HSD11B2,CYP21A2,CYP11B1,CYP17A1,HSD11B1
hsa_M00141	C1-unit interconversion, eukaryotes	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	441024,10797,6472,4522,6470,25902	MTHFD2L,MTHFD2,SHMT2,MTHFD1,SHMT1,MTHFD1L
M00395	Decapping complex	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	80153,1656,55802,219988,167227,196513	EDC3,DDX6,DCP1A,PATL1,DCP2,DCP1B
hsa_M00058	Glycosaminoglycan biosynthesis, chondroitin sulfate backbone	0.463528945854574	-0.768886445323005	6	6	0.000952380952380952	6300	7161	22856,55454,55790,79586,54480,337876	CHSY1,CSGALNACT2,CSGALNACT1,CHPF,CHPF2,CHSY3
hsa04216	Ferroptosis	0.464712994953203	-0.76633527910487	40	36	0.00571428571428571	6300	7161	9474,84557,7018,7417,2512,23516,30061,23657,51703,94033,6520,7419,2937,5093,2180,2495,440738,5621,7037,55240,7157,8031,64116,2730,4891,5094,2729,81631,3162,2879,2181,10533,10162,1356,23305,246	ATG5,MAP1LC3A,TF,VDAC2,FTL,SLC39A14,SLC40A1,SLC7A11,ACSL5,FTMT,SLC3A2,VDAC3,GSS,PCBP1,ACSL1,FTH1,MAP1LC3C,PRNP,TFRC,STEAP3,TP53,NCOA4,SLC39A8,GCLM,SLC11A2,PCBP2,GCLC,MAP1LC3B,HMOX1,GPX4,ACSL3,ATG7,LPCAT3,CP,ACSL6,ALOX15
ko04216	Ferroptosis	0.464712994953203	-0.76633527910487	40	36	0.00571428571428571	6300	7161	7417,2512,23516,30061,23657,9474,84557,7018,5093,2180,2495,51703,94033,6520,7419,2937,5621,55240,7037,7157,8031,64116,2730,440738,2181,1356,10162,10533,246,23305,4891,2729,5094,81631,3162,2879	VDAC2,FTL,SLC39A14,SLC40A1,SLC7A11,ATG5,MAP1LC3A,TF,PCBP1,ACSL1,FTH1,ACSL5,FTMT,SLC3A2,VDAC3,GSS,PRNP,STEAP3,TFRC,TP53,NCOA4,SLC39A8,GCLM,MAP1LC3C,ACSL3,CP,LPCAT3,ATG7,ALOX15,ACSL6,SLC11A2,GCLC,PCBP2,MAP1LC3B,HMOX1,GPX4
ko00380	Tryptophan metabolism	0.464712994953203	-0.76633527910487	40	36	0.00571428571428571	6300	7161	51166,56267,501,11185,23498,39,223,3620,121278,7166,1962,8942,3033,224,3030,26,1543,130013,15,1545,55753,1644,259307,2639,217,219,169355,1544,6999,316,847,883,38,8564,4967,125061	AADAT,KYAT3,ALDH7A1,INMT,HAAO,ACAT2,ALDH9A1,IDO1,TPH2,TPH1,EHHADH,KYNU,HADH,ALDH3A2,HADHA,AOC1,CYP1A1,ACMSD,AANAT,CYP1B1,OGDHL,DDC,IL4I1,GCDH,ALDH2,ALDH1B1,IDO2,CYP1A2,TDO2,AOX1,CAT,KYAT1,ACAT1,KMO,OGDH,AFMID
hsa00380	Tryptophan metabolism	0.464712994953203	-0.76633527910487	40	36	0.00571428571428571	6300	7161	259307,2639,55753,1644,169355,219,217,38,883,847,8564,316,6999,1544,125061,4967,501,56267,51166,7166,3620,121278,223,11185,23498,39,8942,1962,130013,1543,15,1545,3033,26,3030,224	IL4I1,GCDH,OGDHL,DDC,IDO2,ALDH1B1,ALDH2,ACAT1,KYAT1,CAT,KMO,AOX1,TDO2,CYP1A2,AFMID,OGDH,ALDH7A1,KYAT3,AADAT,TPH1,IDO1,TPH2,ALDH9A1,INMT,HAAO,ACAT2,KYNU,EHHADH,ACMSD,CYP1A1,AANAT,CYP1B1,HADH,AOC1,HADHA,ALDH3A2
hsa00515	Mannose type O-glycan biosynthesis	0.465644236529198	-0.764333377350387	23	21	0.00333333333333333	6300	7161	10690,148789,729920,6487,27087,10329,9215,84892,9486,120071,135152,55624,10585,8703,146664,29954,2218,2683,8704,79147,11041	FUT9,B3GALNT2,CRPPA,ST3GAL3,B3GAT1,RXYLT1,LARGE1,POMGNT2,CHST10,LARGE2,B3GAT2,POMGNT1,POMT1,B4GALT3,MGAT5B,POMT2,FKTN,B4GALT1,B4GALT2,FKRP,B4GAT1
ko00515	Mannose type O-glycan biosynthesis	0.465644236529198	-0.764333377350387	23	21	0.00333333333333333	6300	7161	2218,2683,8704,79147,11041,55624,10585,8703,146664,29954,84892,9215,9486,120071,135152,10690,148789,729920,6487,27087,10329	FKTN,B4GALT1,B4GALT2,FKRP,B4GAT1,POMGNT1,POMT1,B4GALT3,MGAT5B,POMT2,POMGNT2,LARGE1,CHST10,LARGE2,B3GAT2,FUT9,B3GALNT2,CRPPA,ST3GAL3,B3GAT1,RXYLT1
hsa00410	beta-Alanine metabolism	0.478488421997575	-0.737123264834166	31	28	0.00444444444444444	6300	7161	6723,26275,55748,217,219,34,339896,54498,220,222,2571,1806,4329,501,223,314,1807,8639,221,18,1962,51733,2572,218,23417,84735,224,3030	SRM,HIBCH,CNDP2,ALDH2,ALDH1B1,ACADM,GADL1,SMOX,ALDH1A3,ALDH3B2,GAD1,DPYD,ALDH6A1,ALDH7A1,ALDH9A1,AOC2,DPYS,AOC3,ALDH3B1,ABAT,EHHADH,UPB1,GAD2,ALDH3A1,MLYCD,CNDP1,ALDH3A2,HADHA
ko00410	beta-Alanine metabolism	0.478488421997575	-0.737123264834166	31	28	0.00444444444444444	6300	7161	219,217,26275,55748,6723,2571,222,54498,339896,220,34,8639,314,1807,223,501,4329,1806,84735,218,23417,3030,224,51733,2572,1962,18,221	ALDH1B1,ALDH2,HIBCH,CNDP2,SRM,GAD1,ALDH3B2,SMOX,GADL1,ALDH1A3,ACADM,AOC3,AOC2,DPYS,ALDH9A1,ALDH7A1,ALDH6A1,DPYD,CNDP1,ALDH3A1,MLYCD,HADHA,ALDH3A2,UPB1,GAD2,EHHADH,ABAT,ALDH3B1
ko04142	Lysosome	0.481514768797527	-0.730818375737656	123	109	0.0173015873015873	6300	7161	967,23163,4891,53,23062,256471,54,1519,9741,5538,2990,2588,1200,1211,2629,2720,26088,1513,1512,1521,6556,427,57192,768239,26503,2799,9516,10312,6272,8218,6448,8722,23457,10577,533,535,1203,4668,7805,1510,23545,3425,9583,8546,950,968,164,5641,51606,8907,1511,1508,3074,175,2517,10239,8120,130340,1075,3916,1522,9114,10717,50617,3373,162,55353,84572,6609,10947,3988,4864,23431,4125,1174,51172,23659,4074,245972,1213,2548,1212,2760,27074,1497,11154,1514,1520,411,8763,4758,4126,285362,79158,26985,8943,1515,3482,1509,58511,5660,22901,1777,10053,8906,138050,2581,1176,1201	CD63,GGA3,SLC11A2,ACP2,GGA2,MFSD8,ACP5,CTSO,LAPTM4A,PPT1,GUSB,GALNS,TPP1,CLTA,GBA1,GLB1,GGA1,CTSK,CTSH,CTSW,SLC11A1,ASAH1,MCOLN1,PSAPL1,SLC17A5,GNS,LITAF,TCIRG1,SORT1,CLTCL1,SGSH,CTSF,ABCB9,NPC2,ATP6V0B,ATP6V0A1,CLN5,NAGA,LAPTM5,CTSE,ATP6V0A2,IDUA,ENTPD4,AP3B1,SCARB2,CD68,AP1G1,LGMN,ATP6V1H,AP1M1,CTSG,CTSB,HEXB,AGA,FUCA1,AP3S2,AP3B2,AP1S3,CTSC,LAMP1,CTSZ,ATP6V0D1,AP4B1,ATP6V0A4,HYAL1,AP1B1,LAPTM4B,GNPTG,SMPD1,AP3M2,LIPA,NPC1,AP4E1,MAN2B1,AP1S1,NAGPA,PLA2G15,M6PR,ATP6V0D2,CLTC,GAA,CLTB,GM2A,LAMP3,CTNS,AP4S1,CTSL,CTSS,ARSB,CD164,NEU1,MANBA,SUMF1,GNPTAB,AP3M1,AP3D1,CTSV,IGF2R,CTSD,DNASE2B,PSAP,ARSG,DNASE2,AP1M2,AP1G2,HGSNAT,GALC,AP3S1,CLN3
hsa04142	Lysosome	0.481514768797527	-0.730818375737656	123	109	0.0173015873015873	6300	7161	3425,23545,1510,7805,950,8546,9583,5641,164,968,8907,51606,6448,8218,6272,10312,10577,23457,8722,533,4668,1203,535,1512,26088,1513,2720,2629,6556,1521,26503,768239,57192,427,2799,9516,23163,967,1519,54,256471,23062,53,4891,5538,9741,2588,1200,1211,2990,3482,1515,8943,22901,5660,58511,1509,8906,1777,10053,2581,1201,1176,138050,11154,1497,27074,411,1520,1514,285362,4126,4758,8763,26985,79158,1174,51172,4125,23431,4864,23659,1212,2548,2760,1213,245972,4074,10239,2517,175,3074,1511,1508,1522,3916,1075,130340,8120,55353,162,50617,3373,10717,9114,3988,6609,10947,84572	IDUA,ATP6V0A2,CTSE,LAPTM5,SCARB2,AP3B1,ENTPD4,LGMN,AP1G1,CD68,AP1M1,ATP6V1H,SGSH,CLTCL1,SORT1,TCIRG1,NPC2,ABCB9,CTSF,ATP6V0B,NAGA,CLN5,ATP6V0A1,CTSH,GGA1,CTSK,GLB1,GBA1,SLC11A1,CTSW,SLC17A5,PSAPL1,MCOLN1,ASAH1,GNS,LITAF,GGA3,CD63,CTSO,ACP5,MFSD8,GGA2,ACP2,SLC11A2,PPT1,LAPTM4A,GALNS,TPP1,CLTA,GUSB,IGF2R,CTSV,AP3D1,ARSG,PSAP,DNASE2B,CTSD,AP1G2,DNASE2,AP1M2,GALC,CLN3,AP3S1,HGSNAT,AP4S1,CTNS,LAMP3,ARSB,CTSS,CTSL,SUMF1,MANBA,NEU1,CD164,AP3M1,GNPTAB,AP1S1,NAGPA,MAN2B1,AP4E1,NPC1,PLA2G15,CLTB,GAA,GM2A,CLTC,ATP6V0D2,M6PR,AP3S2,FUCA1,AGA,HEXB,CTSG,CTSB,CTSZ,LAMP1,CTSC,AP1S3,AP3B2,LAPTM4B,AP1B1,ATP6V0A4,HYAL1,AP4B1,ATP6V0D1,LIPA,SMPD1,AP3M2,GNPTG
hsa04974	Protein digestion and absorption	0.490070304692461	-0.713206419205381	89	79	0.0125396825396825	6300	7161	1360,85301,23428,256076,482,10008,1282,477,63036,6550,1297,1359,1357,1299,486,4225,1302,1303,255631,1289,481,476,1506,51032,3784,1306,5547,1281,54407,1301,5646,131873,6519,1286,206358,1278,1293,4224,6505,9056,2006,480,6564,7373,340024,1285,1280,4311,50509,1277,1803,23436,6543,1305,1308,1300,643834,1294,6510,8645,5222,6547,117247,5644,1361,1358,1284,6546,643847,1504,6520,169044,10136,1298,1290,478,483,11136,81578	CPB1,COL27A1,SLC7A8,COL6A5,ATP1B2,KCNE3,COL4A1,ATP1A2,CELA2A,SLC9A3,COL9A1,CPA3,CPA1,COL9A3,FXYD2,MEP1B,COL11A2,COL12A1,COL24A1,COL5A1,ATP1B1,ATP1A1,CTRL,CELA2B,KCNQ1,COL15A1,PRCP,COL3A1,SLC38A2,COL11A1,PRSS3,COL6A6,SLC3A1,COL4A4,SLC36A1,COL1A2,COL6A3,MEP1A,SLC1A1,SLC7A7,ELN,ATP1A4,SLC15A1,COL14A1,SLC6A19,COL4A3,COL2A1,MME,COL5A3,COL1A1,DPP4,CELA3B,SLC8A2,COL13A1,COL17A1,COL10A1,PGA3,COL7A1,SLC1A5,KCNK5,PGA5,SLC8A3,SLC16A10,PRSS1,CPB2,CPA2,COL4A2,SLC8A1,PGA4,CTRB1,SLC3A2,COL22A1,CELA3A,COL9A2,COL5A2,ATP1A3,ATP1B3,SLC7A9,COL21A1
ko04974	Protein digestion and absorption	0.490070304692461	-0.713206419205381	89	79	0.0125396825396825	6300	7161	8645,6510,1294,643834,1300,1308,6543,1305,1803,23436,1277,50509,4311,1280,1285,340024,7373,6564,480,2006,9056,81578,11136,478,483,1298,1290,10136,169044,6520,643847,1504,6546,1284,1358,1361,5644,117247,5222,6547,255631,1303,1302,4225,1299,486,1357,1359,1297,6550,63036,477,1282,10008,482,23428,256076,85301,1360,6505,4224,1293,1278,206358,1286,6519,5646,131873,1301,54407,1281,1306,5547,3784,51032,1506,476,1289,481	KCNK5,SLC1A5,COL7A1,PGA3,COL10A1,COL17A1,SLC8A2,COL13A1,DPP4,CELA3B,COL1A1,COL5A3,MME,COL2A1,COL4A3,SLC6A19,COL14A1,SLC15A1,ATP1A4,ELN,SLC7A7,COL21A1,SLC7A9,ATP1A3,ATP1B3,COL9A2,COL5A2,CELA3A,COL22A1,SLC3A2,PGA4,CTRB1,SLC8A1,COL4A2,CPA2,CPB2,PRSS1,SLC16A10,PGA5,SLC8A3,COL24A1,COL12A1,COL11A2,MEP1B,COL9A3,FXYD2,CPA1,CPA3,COL9A1,SLC9A3,CELA2A,ATP1A2,COL4A1,KCNE3,ATP1B2,SLC7A8,COL6A5,COL27A1,CPB1,SLC1A1,MEP1A,COL6A3,COL1A2,SLC36A1,COL4A4,SLC3A1,PRSS3,COL6A6,COL11A1,SLC38A2,COL3A1,COL15A1,PRCP,KCNQ1,CELA2B,CTRL,ATP1A1,COL5A1,ATP1B1
hsa00900	Terpenoid backbone biosynthesis	0.496673521507984	-0.699822367112058	22	20	0.00317460317460317	6300	7161	2224,51449,57107,2339,23463,3422,9986,4598,38,10654,39,3157,23590,9453,10269,3156,116150,2342,4597,79947	FDPS,PCYOX1,PDSS2,FNTA,ICMT,IDI1,RCE1,MVK,ACAT1,PMVK,ACAT2,HMGCS1,PDSS1,GGPS1,ZMPSTE24,HMGCR,NUS1,FNTB,MVD,DHDDS
hsa00514	Other types of O-glycan biosynthesis	0.496673521507984	-0.699822367112058	22	20	0.00317460317460317	6300	7161	8985,3955,8703,23127,29954,23275,10585,6480,4242,285203,5986,283464,727936,2683,8704,6487,23509,79709,145173,84620	PLOD3,LFNG,B4GALT3,COLGALT2,POMT2,POFUT2,POMT1,ST6GAL1,MFNG,EOGT,RFNG,GXYLT1,GXYLT2,B4GALT1,B4GALT2,ST3GAL3,POFUT1,COLGALT1,B3GLCT,ST6GAL2
ko00900	Terpenoid backbone biosynthesis	0.496673521507984	-0.699822367112058	22	20	0.00317460317460317	6300	7161	116150,3156,4597,2342,79947,3157,39,10654,23590,9453,10269,3422,9986,4598,38,2224,51449,57107,23463,2339	NUS1,HMGCR,MVD,FNTB,DHDDS,HMGCS1,ACAT2,PMVK,PDSS1,GGPS1,ZMPSTE24,IDI1,RCE1,MVK,ACAT1,FDPS,PCYOX1,PDSS2,ICMT,FNTA
ko00514	Other types of O-glycan biosynthesis	0.496673521507984	-0.699822367112058	22	20	0.00317460317460317	6300	7161	4242,285203,283464,5986,8704,2683,727936,3955,8985,29954,23127,8703,10585,23275,6480,79709,84620,145173,6487,23509	MFNG,EOGT,GXYLT1,RFNG,B4GALT2,B4GALT1,GXYLT2,LFNG,PLOD3,POMT2,COLGALT2,B4GALT3,POMT1,POFUT2,ST6GAL1,COLGALT1,ST6GAL2,B3GLCT,ST3GAL3,POFUT1
hsa00020	Citrate cycle (TCA cycle)	0.505251107873945	-0.682699729976525	30	27	0.00428571428571429	6300	7161	3418,4967,6389,47,5091,1738,5162,4190,6392,1431,1743,5105,55753,2271,6390,8801,3420,3419,5161,4191,48,3417,50,8803,8802,1737,6391	IDH2,OGDH,SDHA,ACLY,PC,DLD,PDHB,MDH1,SDHD,CS,DLST,PCK1,OGDHL,FH,SDHB,SUCLG2,IDH3B,IDH3A,PDHA2,MDH2,ACO1,IDH1,ACO2,SUCLA2,SUCLG1,DLAT,SDHC
ko00020	Citrate cycle (TCA cycle)	0.505251107873945	-0.682699729976525	30	27	0.00428571428571429	6300	7161	4190,8801,6392,5105,1743,55753,1431,2271,6390,47,3418,4967,6389,1738,5162,5091,4191,48,3417,6391,50,8803,8802,1737,3420,3419,5161	MDH1,SUCLG2,SDHD,PCK1,DLST,OGDHL,CS,FH,SDHB,ACLY,IDH2,OGDH,SDHA,DLD,PDHB,PC,MDH2,ACO1,IDH1,SDHC,ACO2,SUCLA2,SUCLG1,DLAT,IDH3B,IDH3A,PDHA2
ko04721	Synaptic vesicle cycle	0.508056599838782	-0.677162420604592	63	56	0.00888888888888889	6300	7161	1759,773,22999,155066,4905,526,246213,6844,112755,127124,161,1213,1212,23025,90423,245972,51382,1175,339302,6812,57084,9550,50617,9114,5864,6570,1211,23545,163,26052,6857,440279,6616,528,8992,1785,2054,51606,10815,6571,529,523,6809,10312,594855,8218,10814,1173,245973,57030,525,140679,10497,533,160,535	DNM1,CACNA1A,RIMS1,ATP6V0E2,NSF,ATP6V1B2,SLC17A8,VAMP2,STX1B,ATP6V1G3,AP2A2,CLTC,CLTB,UNC13A,ATP6V1E2,ATP6V0D2,ATP6V1D,AP2S1,CPLX4,STXBP1,SLC17A6,ATP6V1G1,ATP6V0A4,ATP6V0D1,RAB3A,SLC18A1,CLTA,ATP6V0A2,AP2B1,DNM3,SYT1,UNC13C,SNAP25,ATP6V1C1,ATP6V0E1,DNM2,STX2,ATP6V1H,CPLX1,SLC18A2,ATP6V1E1,ATP6V1A,STX3,TCIRG1,CPLX3,CLTCL1,CPLX2,AP2M1,ATP6V1C2,SLC17A7,ATP6V1B1,SLC32A1,UNC13B,ATP6V0B,AP2A1,ATP6V0A1
hsa04721	Synaptic vesicle cycle	0.508056599838782	-0.677162420604592	63	56	0.00888888888888889	6300	7161	57030,10497,140679,525,523,6809,529,8218,594855,10312,1173,10814,245973,160,535,533,26052,6857,6616,440279,23545,163,2054,10815,51606,6571,528,8992,1785,339302,57084,6812,51382,1175,5864,6570,1211,9550,50617,9114,246213,526,4905,6844,773,1759,22999,155066,161,1212,1213,245972,90423,23025,112755,127124	SLC17A7,UNC13B,SLC32A1,ATP6V1B1,ATP6V1A,STX3,ATP6V1E1,CLTCL1,CPLX3,TCIRG1,AP2M1,CPLX2,ATP6V1C2,AP2A1,ATP6V0A1,ATP6V0B,DNM3,SYT1,SNAP25,UNC13C,ATP6V0A2,AP2B1,STX2,CPLX1,ATP6V1H,SLC18A2,ATP6V1C1,ATP6V0E1,DNM2,CPLX4,SLC17A6,STXBP1,ATP6V1D,AP2S1,RAB3A,SLC18A1,CLTA,ATP6V1G1,ATP6V0A4,ATP6V0D1,SLC17A8,ATP6V1B2,NSF,VAMP2,CACNA1A,DNM1,RIMS1,ATP6V0E2,AP2A2,CLTB,CLTC,ATP6V0D2,ATP6V1E2,UNC13A,STX1B,ATP6V1G3
hsa05012	Parkinson's disease	0.512293789796455	-0.668857010311401	129	114	0.0180952380952381	6300	7161	518,4707,6392,55967,7327,6570,126328,4715,291,4709,5567,6389,54205,7345,4698,1327,522,7416,2774,1350,4702,1345,513,509,4714,836,1329,4728,4720,515,111,10476,6390,374291,10975,341947,7332,1339,1346,1337,7054,4697,4729,135,2771,4716,6622,5568,517,4708,4700,4711,9246,498,4723,7314,4722,7326,2770,4706,4724,5566,7384,4710,4718,9627,4695,842,6391,7417,514,4731,6531,1340,65018,9377,7385,7419,4725,4726,170712,2773,539,7386,1347,56901,51079,1351,11315,7318,506,4712,5071,29796,516,440567,83447,4704,7381,4696,4717,10105,9167,6571,27429,120892,4705,51465,2861,1812,1813,317,118424,4719	ATP5MC3,NDUFB1,SDHD,NDUFA12,UBE2G2,SLC18A1,NDUFA11,NDUFB9,SLC25A4,NDUFB3,PRKACB,SDHA,CYCS,UCHL1,NDUFA5,COX4I1,ATP5PF,VDAC1,GNAL,COX7C,NDUFA8,COX6C,ATP5F1D,ATP5F1C,NDUFB8,CASP3,COX5B,NDUFS8,NDUFS2,ATP5PB,ADCY5,ATP5PD,SDHB,NDUFS7,UQCR11,COX8C,UBE2L3,COX6A2,COX7A1,COX6A1,TH,NDUFA4,NDUFV2,ADORA2A,GNAI2,NDUFB10,SNCA,PRKACG,ATP5MC2,NDUFB2,NDUFA6,NDUFB5,UBE2L6,ATP5F1A,NDUFV1,UBB,NDUFS3,UBE2G1,GNAI1,NDUFAB1,NDUFS4,PRKACA,UQCRC1,NDUFB4,NDUFC2,SNCAIP,NDUFA2,CASP9,SDHC,VDAC2,ATP5F1E,NDUFV3,SLC6A3,COX6B1,PINK1,COX5A,UQCRC2,VDAC3,NDUFS5,NDUFS6,COX7B2,GNAI3,ATP5PO,UQCRFS1,COX7A2,NDUFA4L2,NDUFA13,COX8A,PARK7,UBA7,ATP5F1B,NDUFB6,PRKN,UQCR10,ATP5MC1,UQCRHL,SLC25A31,NDUFA9,UQCRB,NDUFA3,NDUFC1,PPIF,COX7A2L,SLC18A2,HTRA2,LRRK2,NDUFA10,UBE2J1,GPR37,DRD1,DRD2,APAF1,UBE2J2,NDUFS1
hsa04380	Osteoclast differentiation	0.512293789796455	-0.668857010311401	129	114	0.0180952380952381	6300	7161	3455,5530,3725,7046,54,5295,8878,10859,11006,1385,23118,1535,9846,5608,5600,4791,8792,3554,3454,7189,1435,7132,2212,1540,2213,8600,7305,814,1513,6885,2274,5532,5533,5609,1436,11027,7297,3460,29760,5599,9021,8503,5603,5602,10326,3551,5879,5296,2353,5291,3726,5970,3456,6850,9020,4792,9103,3458,5535,5604,5595,5290,3690,2534,4688,2354,10454,5971,140885,5534,5594,7042,7124,10000,2355,208,1147,6772,6773,3937,4790,5601,4772,4773,207,3553,2885,3552,50508,5293,2214,10379,3716,55423,653361,6688,8651,8061,4286,1432,3459,5468,7040,7048,799,3932,4689,2215,6300,2209,5336,11024,3727,4982	IFNAR2,PPP3CA,JUN,TGFBR1,ACP5,PIK3R1,SQSTM1,LILRB1,LILRB4,CREB1,TAB2,CYBA,GAB2,MAP2K6,MAPK11,NFKB2,TNFRSF11A,IL1R1,IFNAR1,TRAF6,CSF1,TNFRSF1A,FCGR2A,CYLD,FCGR2B,TNFSF11,TYROBP,CAMK4,CTSK,MAP3K7,FHL2,PPP3CB,PPP3CC,MAP2K7,CSF1R,LILRA2,TYK2,IFNGR2,BLNK,MAPK8,SOCS3,PIK3R3,MAPK13,MAPK10,SIRPB1,IKBKB,RAC1,PIK3R2,FOS,PIK3CB,JUNB,RELA,IFNB1,SYK,MAP3K14,NFKBIA,FCGR2C,IFNG,PPP3R2,MAP2K1,MAPK3,PIK3CA,ITGB3,FYN,NCF2,FOSB,TAB1,RELB,SIRPA,PPP3R1,MAPK1,TGFB2,TNF,AKT3,FOSL2,AKT2,CHUK,STAT1,STAT2,LCP2,NFKB1,MAPK9,NFATC1,NFATC2,AKT1,IL1B,GRB2,IL1A,NOX3,PIK3CD,FCGR3A,IRF9,JAK1,SIRPG,NCF1,SPI1,SOCS1,FOSL1,MITF,MAPK14,IFNGR1,PPARG,TGFB1,TGFBR2,CALCR,LCK,NCF4,FCGR3B,MAPK12,FCGR1A,PLCG2,LILRA1,JUND,TNFRSF11B
ko04380	Osteoclast differentiation	0.512293789796455	-0.668857010311401	129	114	0.0180952380952381	6300	7161	1147,6773,6772,208,10000,2355,7042,7124,5594,5534,140885,10454,5971,4688,2354,2534,3690,5290,5595,5604,5535,3458,9103,9020,6850,4792,4982,3727,11024,5336,2209,3932,4689,799,6300,2215,1432,3459,5468,7040,7048,4286,6688,8651,653361,8061,10379,3716,55423,2214,50508,5293,207,3552,2885,3553,5601,4790,3937,4773,4772,6885,1513,7305,814,2213,2212,1540,8600,7132,1435,7189,3454,4791,5600,5608,8792,3554,1535,9846,23118,1385,11006,10859,8878,7046,5295,54,3725,5530,3455,5970,3456,3726,5291,2353,3551,10326,5296,5879,8503,9021,5602,5603,7297,29760,5599,3460,11027,1436,5609,5533,5532,2274	CHUK,STAT2,STAT1,AKT2,AKT3,FOSL2,TGFB2,TNF,MAPK1,PPP3R1,SIRPA,TAB1,RELB,NCF2,FOSB,FYN,ITGB3,PIK3CA,MAPK3,MAP2K1,PPP3R2,IFNG,FCGR2C,MAP3K14,SYK,NFKBIA,TNFRSF11B,JUND,LILRA1,PLCG2,FCGR1A,LCK,NCF4,CALCR,MAPK12,FCGR3B,MAPK14,IFNGR1,PPARG,TGFB1,TGFBR2,MITF,SPI1,SOCS1,NCF1,FOSL1,IRF9,JAK1,SIRPG,FCGR3A,NOX3,PIK3CD,AKT1,IL1A,GRB2,IL1B,MAPK9,NFKB1,LCP2,NFATC2,NFATC1,MAP3K7,CTSK,TYROBP,CAMK4,FCGR2B,FCGR2A,CYLD,TNFSF11,TNFRSF1A,CSF1,TRAF6,IFNAR1,NFKB2,MAPK11,MAP2K6,TNFRSF11A,IL1R1,CYBA,GAB2,TAB2,CREB1,LILRB4,LILRB1,SQSTM1,TGFBR1,PIK3R1,ACP5,JUN,PPP3CA,IFNAR2,RELA,IFNB1,JUNB,PIK3CB,FOS,IKBKB,SIRPB1,PIK3R2,RAC1,PIK3R3,SOCS3,MAPK10,MAPK13,TYK2,BLNK,MAPK8,IFNGR2,LILRA2,CSF1R,MAP2K7,PPP3CC,PPP3CB,FHL2
hsa00562	Inositol phosphate metabolism	0.513079639985844	-0.667324202223292	71	63	0.01	6300	7161	5336,23007,9651,8871,3631,5291,23236,200576,51477,3636,8396,7167,54928,5297,5331,3628,5286,64768,5293,55300,8898,3633,5287,5289,8867,51763,5332,5333,64419,8821,3705,9108,3706,5305,8394,5294,51196,9107,3707,79837,80271,84812,55361,4329,9562,23396,5288,8897,9110,89869,138429,5298,5290,8395,3635,3612,3613,27124,10423,5335,5330,5728,253430	PLCG2,PLCH1,PLCH2,SYNJ2,INPP4A,PIK3CB,PLCB1,PIKFYVE,ISYNA1,INPPL1,PIP4K2B,TPI1,BPNT2,PI4KA,PLCB3,INPP1,PIK3C2A,IPPK,PIK3CD,PI4K2B,MTMR2,INPP5B,PIK3C2B,PIK3C3,SYNJ1,INPP5K,PLCB4,PLCD1,MTMR14,INPP4B,ITPK1,MTMR7,ITPKA,PIP4K2A,PIP5K1A,PIK3CG,PLCE1,MTMR6,ITPKB,PIP4K2C,ITPKC,PLCD4,PI4K2A,ALDH6A1,MINPP1,PIP5K1C,PIK3C2G,MTMR3,MTMR4,PLCZ1,PIP5KL1,PI4KB,PIK3CA,PIP5K1B,INPP5D,IMPA1,IMPA2,INPP5J,CDIPT,PLCG1,PLCB2,PTEN,IPMK
ko00562	Inositol phosphate metabolism	0.513079639985844	-0.667324202223292	71	63	0.01	6300	7161	5336,9651,23007,5291,23236,3631,8871,8396,7167,200576,51477,3636,3628,5331,54928,5297,5286,8898,5287,3633,64768,5293,55300,8867,5289,51763,9108,3705,5333,5332,8821,64419,5305,8394,5294,51196,3706,80271,3707,9107,79837,9562,23396,4329,84812,55361,5288,9110,8897,138429,89869,3635,8395,5298,5290,3613,3612,27124,5728,253430,5330,5335,10423	PLCG2,PLCH2,PLCH1,PIK3CB,PLCB1,INPP4A,SYNJ2,PIP4K2B,TPI1,PIKFYVE,ISYNA1,INPPL1,INPP1,PLCB3,BPNT2,PI4KA,PIK3C2A,MTMR2,PIK3C2B,INPP5B,IPPK,PIK3CD,PI4K2B,SYNJ1,PIK3C3,INPP5K,MTMR7,ITPK1,PLCD1,PLCB4,INPP4B,MTMR14,PIP4K2A,PIP5K1A,PIK3CG,PLCE1,ITPKA,ITPKC,ITPKB,MTMR6,PIP4K2C,MINPP1,PIP5K1C,ALDH6A1,PLCD4,PI4K2A,PIK3C2G,MTMR4,MTMR3,PIP5KL1,PLCZ1,INPP5D,PIP5K1B,PI4KB,PIK3CA,IMPA2,IMPA1,INPP5J,PTEN,IPMK,PLCB2,PLCG1,CDIPT
hsa04120	Ubiquitin mediated proteolysis	0.51592359238314	-0.661796601241883	137	121	0.0192063492063492	6300	7161	8697,9320,23291,11065,51465,7325,9978,868,118424,51366,4734,83737,57448,1643,1642,9021,6921,7318,8453,9063,5071,8452,51343,79444,4591,7324,329,4214,84447,1161,10273,23221,29945,25898,55120,23624,51529,11060,55236,112401,10393,997,8945,54926,9820,10054,9616,3093,26091,10277,7334,7189,26259,148581,51433,140739,11059,89910,9690,7321,8916,10055,7326,51619,23327,867,23759,4193,6500,26232,8451,51434,6477,330,64326,8924,7328,7320,9246,7337,7428,22954,57154,9817,55585,8651,51588,8925,64750,64682,55294,10477,26272,7332,6923,23295,22888,326,6502,8554,8454,7322,7323,378884,9354,55958,5371,991,55284,7329,134111,9039,55070,996,92912,63893,65264,8065,672,9886,7327	CDC23,TRIP12,FBXW11,UBE2C,UBE2J1,UBE2E2,RBX1,CBLB,UBE2J2,UBR5,NEDD4,ITCH,BIRC6,DDB2,DDB1,SOCS3,ELOC,UBA7,CUL2,PIAS2,PRKN,CUL3,FZR1,BIRC7,TRIM37,UBE2E1,BIRC2,MAP3K1,SYVN1,ERCC8,STUB1,RHOBTB2,ANAPC4,RCHY1,FANCL,CBLC,ANAPC11,WWP2,UBA6,BIRC8,ANAPC10,CDC34,BTRC,UBE2R2,CUL7,UBA2,RNF7,UBE2K,HERC4,UBE4B,UBE2N,TRAF6,FBXW8,UBE2U,ANAPC5,UBE2F,WWP1,UBE3B,UBE3C,UBE2D1,HERC3,SAE1,UBE2G1,UBE2D4,NEDD4L,CBL,PPIL2,MDM2,SKP1,FBXO2,CUL4A,ANAPC7,SIAH1,BIRC3,COP1,HERC2,UBE2H,UBE2B,UBE2L6,UBE3A,VHL,TRIM32,SMURF1,KEAP1,UBE2Q1,SOCS1,PIAS4,HERC1,SMURF2,ANAPC1,FBXW7,UBE2E3,FBXO4,UBE2L3,ELOB,MGRN1,UBOX5,AIRE,SKP2,PIAS1,CUL1,UBE2D2,UBE2D3,NHLRC1,UBE4A,KLHL9,PML,CDC20,UBE2W,UBE2I,UBE2QL1,UBA3,DET1,CDC27,UBE2Q2,UBE2O,UBE2Z,CUL5,BRCA1,RHOBTB1,UBE2G2
ko04120	Ubiquitin mediated proteolysis	0.51592359238314	-0.661796601241883	137	121	0.0192063492063492	6300	7161	10054,9616,3093,8945,54926,997,10393,9820,148581,51433,140739,10277,26091,26259,7189,7334,89910,9690,7321,11059,51619,4193,23327,867,23759,10055,8916,7326,9978,7325,118424,868,51366,9320,8697,11065,51465,23291,9021,6921,1643,1642,83737,57448,4734,329,23221,84447,4214,1161,10273,7318,4591,7324,8453,5071,9063,79444,51343,8452,11060,51529,55236,112401,25898,29945,55120,23624,7322,7323,8454,378884,6502,22888,326,8554,991,55284,5371,9354,55958,996,63893,65264,92912,134111,7329,9039,55070,672,9886,8065,7327,9246,64326,7320,7328,8924,22954,57154,7428,7337,26232,51434,8451,6500,330,6477,9817,8651,55585,64750,8925,51588,7332,23295,6923,64682,55294,26272,10477	UBA2,RNF7,UBE2K,BTRC,UBE2R2,CDC34,ANAPC10,CUL7,UBE2U,ANAPC5,UBE2F,UBE4B,HERC4,FBXW8,TRAF6,UBE2N,UBE3B,UBE3C,UBE2D1,WWP1,UBE2D4,MDM2,NEDD4L,CBL,PPIL2,SAE1,HERC3,UBE2G1,RBX1,UBE2E2,UBE2J2,CBLB,UBR5,TRIP12,CDC23,UBE2C,UBE2J1,FBXW11,SOCS3,ELOC,DDB2,DDB1,ITCH,BIRC6,NEDD4,BIRC2,RHOBTB2,SYVN1,MAP3K1,ERCC8,STUB1,UBA7,TRIM37,UBE2E1,CUL2,PRKN,PIAS2,BIRC7,FZR1,CUL3,WWP2,ANAPC11,UBA6,BIRC8,RCHY1,ANAPC4,FANCL,CBLC,UBE2D2,UBE2D3,CUL1,NHLRC1,SKP2,UBOX5,AIRE,PIAS1,CDC20,UBE2W,PML,UBE4A,KLHL9,CDC27,UBE2O,UBE2Z,UBE2Q2,UBE2QL1,UBE2I,UBA3,DET1,BRCA1,RHOBTB1,CUL5,UBE2G2,UBE2L6,COP1,UBE2B,UBE2H,HERC2,TRIM32,SMURF1,VHL,UBE3A,FBXO2,ANAPC7,CUL4A,SKP1,BIRC3,SIAH1,KEAP1,SOCS1,UBE2Q1,SMURF2,HERC1,PIAS4,UBE2L3,MGRN1,ELOB,ANAPC1,FBXW7,FBXO4,UBE2E3
hsa00480	Glutathione metabolism	0.522515062208473	-0.649101468365417	54	48	0.00761904761904762	6300	7161	2950,2882,6723,2938,79017,5226,2940,373156,2948,6241,124975,4258,3417,2878,2944,493869,51056,27306,50484,2730,2953,2880,2952,2877,6240,4953,4259,2876,4257,2729,2879,3418,2686,257202,2946,2939,2687,9446,2947,2678,119391,2936,2949,290,221357,2937,2941,9027	GSTP1,GPX7,SRM,GSTA1,GGCT,PGD,GSTA3,GSTK1,GSTM4,RRM2,GGT6,MGST2,IDH1,GPX3,GSTM1,GPX8,LAP3,HPGDS,RRM2B,GCLM,GSTT2,GPX5,GSTT1,GPX2,RRM1,ODC1,MGST3,GPX1,MGST1,GCLC,GPX4,IDH2,GGT7,GPX6,GSTM2,GSTA2,GGT5,GSTO1,GSTM3,GGT1,GSTO2,GSR,GSTM5,ANPEP,GSTA5,GSS,GSTA4,NAT8
ko03460	Fanconi anemia pathway	0.522515062208473	-0.649101468365417	54	48	0.00761904761904762	6300	7161	80010,57599,201254,6118,9894,4292,2177,2188,55215,675,84126,353497,5888,2176,11201,197342,55120,29089,545,2072,641,80233,2067,51426,22909,3280,91442,116028,83990,84464,146956,8940,100526739,6119,5980,2178,2175,57697,7398,672,51455,7156,5395,5429,5889,79728,2189,6117	RMI1,WDR48,CENPX,RPA2,TELO2,MLH1,FANCD2,FANCF,FANCI,BRCA2,ATRIP,POLN,RAD51,FANCC,POLI,EME2,FANCL,UBE2T,ATR,ERCC4,BLM,FAAP100,ERCC1,POLK,FAN1,HES1,FAAP24,RMI2,BRIP1,SLX4,EME1,TOP3B,CENPS-CORT,RPA3,REV3L,FANCE,FANCA,FANCM,USP1,BRCA1,REV1,TOP3A,PMS2,POLH,RAD51C,PALB2,FANCG,RPA1
ko00480	Glutathione metabolism	0.522515062208473	-0.649101468365417	54	48	0.00761904761904762	6300	7161	4257,2729,3418,2879,2877,6240,2730,2880,2953,2952,2876,4953,4259,119391,2949,2936,2941,9027,290,2937,221357,2939,2946,2686,257202,2947,2678,2687,9446,5226,79017,2948,373156,2940,6723,2950,2882,2938,2944,2878,50484,493869,51056,27306,6241,124975,4258,3417	MGST1,GCLC,IDH2,GPX4,GPX2,RRM1,GCLM,GPX5,GSTT2,GSTT1,GPX1,ODC1,MGST3,GSTO2,GSTM5,GSR,GSTA4,NAT8,ANPEP,GSS,GSTA5,GSTA2,GSTM2,GGT7,GPX6,GSTM3,GGT1,GGT5,GSTO1,PGD,GGCT,GSTM4,GSTK1,GSTA3,SRM,GSTP1,GPX7,GSTA1,GSTM1,GPX3,RRM2B,GPX8,LAP3,HPGDS,RRM2,GGT6,MGST2,IDH1
hsa03460	Fanconi anemia pathway	0.522515062208473	-0.649101468365417	54	48	0.00761904761904762	6300	7161	57599,80010,4292,9894,6118,201254,2177,55215,2188,675,353497,84126,5888,2176,11201,197342,55120,29089,545,2072,80233,641,2067,51426,22909,3280,91442,116028,83990,84464,146956,8940,100526739,6119,2175,5980,2178,57697,672,7398,51455,7156,5395,5429,79728,5889,2189,6117	WDR48,RMI1,MLH1,TELO2,RPA2,CENPX,FANCD2,FANCI,FANCF,BRCA2,POLN,ATRIP,RAD51,FANCC,POLI,EME2,FANCL,UBE2T,ATR,ERCC4,FAAP100,BLM,ERCC1,POLK,FAN1,HES1,FAAP24,RMI2,BRIP1,SLX4,EME1,TOP3B,CENPS-CORT,RPA3,FANCA,REV3L,FANCE,FANCM,BRCA1,USP1,REV1,TOP3A,PMS2,POLH,PALB2,RAD51C,FANCG,RPA1
M00036	Leucine degradation, leucine => acetoacetate + acetyl-CoA	0.525019967043734	-0.644318984649473	13	12	0.0019047619047619	6300	7161	56922,593,3712,54511,3155,586,594,1629,34,1738,549,587	MCCC1,BCKDHA,IVD,HMGCLL1,HMGCL,BCAT1,BCKDHB,DBT,ACADM,DLD,AUH,BCAT2
ko00061	Fatty acid biosynthesis	0.525019967043734	-0.644318984649473	13	12	0.0019047619047619	6300	7161	81616,55301,51703,23305,27349,2180,2181,2194,54995,23205,32,31	ACSBG2,OLAH,ACSL5,ACSL6,MCAT,ACSL1,ACSL3,FASN,OXSM,ACSBG1,ACACB,ACACA
hsa00061	Fatty acid biosynthesis	0.525019967043734	-0.644318984649473	13	12	0.0019047619047619	6300	7161	31,32,23205,54995,2194,2181,2180,27349,23305,51703,55301,81616	ACACA,ACACB,ACSBG1,OXSM,FASN,ACSL3,ACSL1,MCAT,ACSL6,ACSL5,OLAH,ACSBG2
hsa_M00036	Leucine degradation, leucine => acetoacetate + acetyl-CoA	0.525019967043734	-0.644318984649473	13	12	0.0019047619047619	6300	7161	34,1738,3155,56922,593,54511,549,587,1629,586,594,3712	ACADM,DLD,HMGCL,MCCC1,BCKDHA,HMGCLL1,AUH,BCAT2,DBT,BCAT1,BCKDHB,IVD
M00071	Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	2683,8704,84002,8703,8702	B4GALT1,B4GALT2,B3GNT5,B4GALT3,B4GALT4
hsa_M00414	Bloom's syndrome complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	7156,80010,116028,8940,641	TOP3A,RMI1,RMI2,TOP3B,BLM
hsa_M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	51805,10229,84274,27235,51004	COQ3,COQ7,COQ5,COQ2,COQ6
M00414	Bloom's syndrome complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	7156,641,116028,8940,80010	TOP3A,BLM,RMI2,TOP3B,RMI1
hsa_M00057	Glycosaminoglycan biosynthesis, linkage tetrasaccharide	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	11285,26229,64131,64132,126792	B4GALT7,B3GAT3,XYLT1,XYLT2,B3GALT6
hsa_M00044	Tyrosine degradation, tyrosine => homogentisate	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	3242,259307,2184,2954,3081	HPD,IL4I1,FAH,GSTZ1,HGD
M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	27235,51004,84274,10229,51805	COQ2,COQ6,COQ5,COQ7,COQ3
hsa_M00382	SCF-FBS complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	26232,9978,6500,8454,26270	FBXO2,RBX1,SKP1,CUL1,FBXO6
ko00232	Caffeine metabolism	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	1544,9,7498,10,1548	CYP1A2,NAT1,XDH,NAT2,CYP2A6
M00383	ECV complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	9978,6921,8453,7428,6923	RBX1,ELOC,CUL2,VHL,ELOB
M00380	SCF-BTRC complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	6500,8454,8945,9978,23291	SKP1,CUL1,BTRC,RBX1,FBXW11
ko00524	Neomycin, kanamycin and gentamicin biosynthesis	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	80201,3098,2645,3099,3101	HKDC1,HK1,GCK,HK2,HK3
M00289	RF-C complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	5982,5983,5985,5984,5981	RFC2,RFC3,RFC5,RFC4,RFC1
hsa_M00289	RF-C complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	5984,5981,5982,5983,5985	RFC4,RFC1,RFC2,RFC3,RFC5
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	3099,2645,3101,3098,80201	HK2,GCK,HK3,HK1,HKDC1
hsa_M00042	Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	7299,1621,7054,1644,5409	TYR,DBH,TH,DDC,PNMT
hsa_M00383	ECV complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	6921,9978,7428,6923,8453	ELOC,RBX1,VHL,ELOB,CUL2
M00042	Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	1621,7299,5409,1644,7054	DBH,TYR,PNMT,DDC,TH
hsa_M00071	Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	8703,84002,8702,2683,8704	B4GALT3,B3GNT5,B4GALT4,B4GALT1,B4GALT2
M00057	Glycosaminoglycan biosynthesis, linkage tetrasaccharide	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	126792,64132,26229,64131,11285	B3GALT6,XYLT2,B3GAT3,XYLT1,B4GALT7
hsa00232	Caffeine metabolism	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	1548,7498,10,1544,9	CYP2A6,XDH,NAT2,CYP1A2,NAT1
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	259307,6898,2805,2806,5053	IL4I1,TAT,GOT1,GOT2,PAH
M00044	Tyrosine degradation, tyrosine => homogentisate	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	3242,259307,2184,2954,3081	HPD,IL4I1,FAH,GSTZ1,HGD
M00382	SCF-FBS complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	6500,8454,9978,26232,26270	SKP1,CUL1,RBX1,FBXO2,FBXO6
hsa_M00380	SCF-BTRC complex	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	8945,9978,8454,6500,23291	BTRC,RBX1,CUL1,SKP1,FBXW11
ko00400	Phenylalanine, tyrosine and tryptophan biosynthesis	0.526928218668996	-0.640690947177063	5	5	0.000793650793650794	6300	7161	2805,6898,259307,5053,2806	GOT1,TAT,IL4I1,PAH,GOT2
hsa_M00049	Adenine ribonucleotide biosynthesis, IMP => ADP,ATP	0.528735304583463	-0.637267341757827	21	19	0.00301587301587302	6300	7161	29922,50808,26289,159,203,205,122481,204,122622,5315,158,10201,5313,4831,654364,221264,4830,4832,4833	NME7,AK3,AK5,ADSS2,AK1,AK4,AK7,AK2,ADSS1,PKM,ADSL,NME6,PKLR,NME2,NME1-NME2,AK9,NME1,NME3,NME4
M00049	Adenine ribonucleotide biosynthesis, IMP => ADP,ATP	0.528735304583463	-0.637267341757827	21	19	0.00301587301587302	6300	7161	205,29922,50808,203,26289,159,4831,221264,654364,4830,4833,4832,122481,204,5315,158,122622,10201,5313	AK4,NME7,AK3,AK1,AK5,ADSS2,NME2,AK9,NME1-NME2,NME1,NME4,NME3,AK7,AK2,PKM,ADSL,ADSS1,NME6,PKLR
ko00760	Nicotinate and nicotinamide metabolism	0.532627620735681	-0.629932746759839	29	26	0.00412698412698413	6300	7161	5169,23057,952,22978,84618,23475,27231,55191,349565,93034,5167,23530,83594,65220,10135,64802,133686,54981,51251,4860,316,56953,4837,683,4907,30833	ENPP3,NMNAT2,CD38,NT5C2,NT5C1A,QPRT,NMRK2,NADSYN1,NMNAT3,NT5C1B,ENPP1,NNT,NUDT12,NADK,NAMPT,NMNAT1,NADK2,NMRK1,NT5C3A,PNP,AOX1,NT5M,NNMT,BST1,NT5E,NT5C
ko00591	Linoleic acid metabolism	0.532627620735681	-0.629932746759839	29	26	0.00412698412698413	6300	7161	123745,1559,391013,11145,8398,50487,5321,1544,246,1557,26279,1576,100137049,81579,1573,283748,1558,84647,5322,5319,5320,8605,151056,255189,30814,64600	PLA2G4E,CYP2C9,PLA2G2C,PLAAT3,PLA2G6,PLA2G3,PLA2G4A,CYP1A2,ALOX15,CYP2C19,PLA2G2D,CYP3A4,PLA2G4B,PLA2G12A,CYP2J2,PLA2G4D,CYP2C8,PLA2G12B,PLA2G5,PLA2G1B,PLA2G2A,PLA2G4C,PLB1,PLA2G4F,PLA2G2E,PLA2G2F
hsa00591	Linoleic acid metabolism	0.532627620735681	-0.629932746759839	29	26	0.00412698412698413	6300	7161	1544,246,1557,26279,1576,100137049,8398,50487,5321,391013,11145,123745,1559,255189,30814,64600,5322,5319,5320,8605,151056,283748,84647,1558,81579,1573	CYP1A2,ALOX15,CYP2C19,PLA2G2D,CYP3A4,PLA2G4B,PLA2G6,PLA2G3,PLA2G4A,PLA2G2C,PLAAT3,PLA2G4E,CYP2C9,PLA2G4F,PLA2G2E,PLA2G2F,PLA2G5,PLA2G1B,PLA2G2A,PLA2G4C,PLB1,PLA2G4D,PLA2G12B,CYP2C8,PLA2G12A,CYP2J2
hsa00760	Nicotinate and nicotinamide metabolism	0.532627620735681	-0.629932746759839	29	26	0.00412698412698413	6300	7161	64802,51251,54981,56953,316,4860,133686,30833,683,4907,4837,5169,84618,22978,23475,952,23057,349565,27231,55191,83594,23530,65220,5167,10135,93034	NMNAT1,NT5C3A,NMRK1,NT5M,AOX1,PNP,NADK2,NT5C,BST1,NT5E,NNMT,ENPP3,NT5C1A,NT5C2,QPRT,CD38,NMNAT2,NMNAT3,NMRK2,NADSYN1,NUDT12,NNT,NADK,ENPP1,NAMPT,NT5C1B
ko05168	Herpes simplex infection	0.534369927460568	-0.626666931807618	185	163	0.0258730158730159	6300	7161	4615,5819,148022,8740,6500,3665,6732,8863,3441,1965,1017,3135,4939,3112,9451,3113,29110,3439,3459,1387,406,3117,6429,3134,1457,6672,5501,10379,3716,3592,9575,3452,3593,3105,355,7185,5610,5601,4790,6430,1459,3553,439996,3119,4049,8454,9519,5187,3444,64135,836,6773,6428,6772,1147,6502,6877,3106,5371,54106,5781,3118,440275,7124,283106,3600,1616,54205,3445,10454,5818,3661,6352,2969,29992,9569,3458,841,4792,4793,2033,6432,4938,6890,10445,3449,3150,2353,10189,3127,27102,3190,3456,8683,7098,5970,5602,8772,9021,9641,5599,27097,3460,6874,7297,5499,1936,3551,6891,3717,3442,3443,6881,6041,3108,3111,25833,7188,972,6426,387332,6875,3122,23586,3123,7187,5500,3107,7132,997,112950,54926,6885,3133,3434,356,23118,7874,3109,3454,7189,10482,6347,6431,29997,6884,8864,3440,3448,727,4940,83860,5430,3569,29915,3455,10629,57506,983,7097,3725,7157,718	MYD88,NECTIN2,TICAM1,TNFSF14,SKP1,IRF7,SRPK1,PER3,IFNA4,EIF2S1,CDK2,HLA-G,OAS2,HLA-DOB,EIF2AK3,HLA-DPA1,TBK1,IFNA1,IFNGR1,CREBBP,BMAL1,HLA-DQA1,SRSF4,HLA-F,CSNK2A1,SP100,PPP1CC,IRF9,JAK1,IL12A,CLOCK,IFNA21,IL12B,HLA-A,FAS,TRAF1,EIF2AK2,MAPK9,NFKB1,SRSF5,CSNK2A2,IL1B,IFIT1B,HLA-DQB1,LTA,CUL1,TBPL1,PER1,IFNA7,IFIH1,CASP3,STAT2,SRSF3,STAT1,CHUK,SKP2,TAF5,HLA-B,PML,TLR9,PTPN11,HLA-DQA2,EIF2AK4,TNF,CSNK2A3,IL15,DAXX,CYCS,IFNA8,TAB1,NECTIN1,IRF3,CCL5,GTF2I,PILRA,GTF2IRD1,IFNG,CASP8,NFKBIA,NFKBIB,EP300,SRSF7,OAS1,TAP1,MCRS1,IFNA16,HMGN1,FOS,ALYREF,HLA-DRB5,EIF2AK1,HNRNPK,IFNB1,SRSF9,TLR3,RELA,MAPK10,FADD,SOCS3,IKBKE,MAPK8,TAF5L,IFNGR2,TAF4,TYK2,PPP1CA,EEF1D,IKBKB,TAP2,JAK2,IFNA5,IFNA6,TAF10,RNASEL,HLA-DMA,HLA-DOA,POU2F3,TRAF5,CD74,SRSF1,TBPL2,TAF4B,HLA-DRA,RIGI,HLA-DRB1,TRAF3,PPP1CB,HLA-C,TNFRSF1A,CDC34,MED8,UBE2R2,MAP3K7,HLA-E,IFIT1,FASLG,TAB2,USP7,HLA-DMB,IFNAR1,TRAF6,NXF1,CCL2,SRSF6,NOP53,TAF13,PER2,IFNA2,IFNA14,C5,OAS3,TAF3,POLR2A,IL6,HCFC2,IFNAR2,TAF6L,MAVS,CDK1,TLR2,JUN,TP53,C3
hsa05168	Herpes simplex infection	0.534369927460568	-0.626666931807618	185	163	0.0258730158730159	6300	7161	9519,8454,4049,836,3444,64135,5187,6502,1147,6772,6773,6428,3106,6877,54106,5371,440275,3118,5781,283106,7124,3600,1616,54205,5818,10454,3445,3661,841,3458,9569,29992,2969,6352,2033,4793,4792,6890,4938,6432,10445,5819,4615,8740,148022,8863,6732,3665,6500,1017,3135,1965,3441,4939,3439,29110,3113,9451,3112,3459,1387,406,3134,1457,6429,3117,5501,6672,3716,10379,3105,3452,3593,9575,3592,4790,5601,5610,7185,355,6430,3119,3553,439996,1459,7187,5500,7132,3107,6885,54926,112950,997,3133,356,3434,23118,3109,7874,6431,6347,3454,7189,10482,8864,6884,29997,727,3448,3440,4940,3455,29915,3569,5430,83860,983,57506,10629,7097,718,7157,3725,3150,3449,10189,2353,3127,5970,7098,8683,27102,3456,3190,9641,9021,8772,5602,7297,6874,3460,5599,27097,3551,5499,1936,6891,3717,3443,3442,6881,25833,3111,3108,6041,6426,972,7188,6875,387332,3123,3122,23586	TBPL1,CUL1,LTA,CASP3,IFNA7,IFIH1,PER1,SKP2,CHUK,STAT1,STAT2,SRSF3,HLA-B,TAF5,TLR9,PML,EIF2AK4,HLA-DQA2,PTPN11,CSNK2A3,TNF,IL15,DAXX,CYCS,NECTIN1,TAB1,IFNA8,IRF3,CASP8,IFNG,GTF2IRD1,PILRA,GTF2I,CCL5,EP300,NFKBIB,NFKBIA,TAP1,OAS1,SRSF7,MCRS1,NECTIN2,MYD88,TNFSF14,TICAM1,PER3,SRPK1,IRF7,SKP1,CDK2,HLA-G,EIF2S1,IFNA4,OAS2,IFNA1,TBK1,HLA-DPA1,EIF2AK3,HLA-DOB,IFNGR1,CREBBP,BMAL1,HLA-F,CSNK2A1,SRSF4,HLA-DQA1,PPP1CC,SP100,JAK1,IRF9,HLA-A,IFNA21,IL12B,CLOCK,IL12A,NFKB1,MAPK9,EIF2AK2,TRAF1,FAS,SRSF5,HLA-DQB1,IL1B,IFIT1B,CSNK2A2,TRAF3,PPP1CB,TNFRSF1A,HLA-C,MAP3K7,UBE2R2,MED8,CDC34,HLA-E,FASLG,IFIT1,TAB2,HLA-DMB,USP7,SRSF6,CCL2,IFNAR1,TRAF6,NXF1,PER2,TAF13,NOP53,C5,IFNA14,IFNA2,OAS3,IFNAR2,HCFC2,IL6,POLR2A,TAF3,CDK1,MAVS,TAF6L,TLR2,C3,TP53,JUN,HMGN1,IFNA16,ALYREF,FOS,HLA-DRB5,RELA,TLR3,SRSF9,EIF2AK1,IFNB1,HNRNPK,IKBKE,SOCS3,FADD,MAPK10,TYK2,TAF4,IFNGR2,MAPK8,TAF5L,IKBKB,PPP1CA,EEF1D,TAP2,JAK2,IFNA6,IFNA5,TAF10,POU2F3,HLA-DOA,HLA-DMA,RNASEL,SRSF1,CD74,TRAF5,TAF4B,TBPL2,HLA-DRB1,HLA-DRA,RIGI
hsa05330	Allograft rejection	0.536281627780063	-0.623095830935893	37	33	0.00523809523809524	6300	7161	3113,5551,3112,3118,356,3565,7124,3109,942,3107,3106,3135,3133,3127,940,958,355,3593,3592,3105,3108,3111,3458,3123,3586,3122,3558,3119,3002,3117,3134,941,3567	HLA-DPA1,PRF1,HLA-DOB,HLA-DQA2,FASLG,IL4,TNF,HLA-DMB,CD86,HLA-C,HLA-B,HLA-G,HLA-E,HLA-DRB5,CD28,CD40,FAS,IL12B,IL12A,HLA-A,HLA-DMA,HLA-DOA,IFNG,HLA-DRB1,IL10,HLA-DRA,IL2,HLA-DQB1,GZMB,HLA-DQA1,HLA-F,CD80,IL5
ko05330	Allograft rejection	0.536281627780063	-0.623095830935893	37	33	0.00523809523809524	6300	7161	942,3107,3127,940,958,3135,3106,3133,356,3113,5551,3112,3118,3565,7124,3109,3117,3134,941,3567,3593,3592,3105,3458,3108,3111,355,3002,3123,3586,3122,3558,3119	CD86,HLA-C,HLA-DRB5,CD28,CD40,HLA-G,HLA-B,HLA-E,FASLG,HLA-DPA1,PRF1,HLA-DOB,HLA-DQA2,IL4,TNF,HLA-DMB,HLA-DQA1,HLA-F,CD80,IL5,IL12B,IL12A,HLA-A,IFNG,HLA-DMA,HLA-DOA,FAS,GZMB,HLA-DRB1,IL10,HLA-DRA,IL2,HLA-DQB1
hsa00650	Butanoate metabolism	0.560524208355618	-0.578882846759226	28	25	0.00396825396825397	6300	7161	142827,64064,2571,35,38,116285,348158,3157,79944,5019,2572,3155,54511,3030,3033,18,1962,6296,7915,65985,56898,39,622,123876,341392	ACSM6,OXCT2,GAD1,ACADS,ACAT1,ACSM1,ACSM2B,HMGCS1,L2HGDH,OXCT1,GAD2,HMGCL,HMGCLL1,HADHA,HADH,ABAT,EHHADH,ACSM3,ALDH5A1,AACS,BDH2,ACAT2,BDH1,ACSM2A,ACSM4
ko00650	Butanoate metabolism	0.560524208355618	-0.578882846759226	28	25	0.00396825396825397	6300	7161	6296,7915,65985,39,56898,622,123876,341392,2572,3155,3030,54511,3033,18,1962,116285,348158,3157,79944,5019,142827,64064,2571,35,38	ACSM3,ALDH5A1,AACS,ACAT2,BDH2,BDH1,ACSM2A,ACSM4,GAD2,HMGCL,HADHA,HMGCLL1,HADH,ABAT,EHHADH,ACSM1,ACSM2B,HMGCS1,L2HGDH,OXCT1,ACSM6,OXCT2,GAD1,ACADS,ACAT1
hsa00670	One carbon pool by folate	0.561705555881181	-0.576777488303097	20	18	0.00285714285714286	6300	7161	4548,275,1719,6470,4522,6472,10797,4524,10588,441024,2618,25902,123263,160428,471,10840,200895,7298	MTR,AMT,DHFR,SHMT1,MTHFD1,SHMT2,MTHFD2,MTHFR,MTHFS,MTHFD2L,GART,MTHFD1L,MTFMT,ALDH1L2,ATIC,ALDH1L1,DHFR2,TYMS
ko00670	One carbon pool by folate	0.561705555881181	-0.576777488303097	20	18	0.00285714285714286	6300	7161	275,1719,6470,4522,6472,4548,10797,4524,2618,25902,123263,10588,441024,7298,160428,10840,471,200895	AMT,DHFR,SHMT1,MTHFD1,SHMT2,MTR,MTHFD2,MTHFR,GART,MTHFD1L,MTFMT,MTHFS,MTHFD2L,TYMS,ALDH1L2,ALDH1L1,ATIC,DHFR2
hsa_M00104	Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate	0.567453657273494	-0.566596194153117	12	11	0.00174603174603175	6300	7161	10005,23600,1109,6718,8309,1593,3295,6342,1581,1582,80270	ACOT8,AMACR,AKR1C4,AKR1D1,ACOX2,CYP27A1,HSD17B4,SCP2,CYP7A1,CYP8B1,HSD3B7
M00104	Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate	0.567453657273494	-0.566596194153117	12	11	0.00174603174603175	6300	7161	80270,1582,1581,6342,3295,1593,6718,8309,1109,10005,23600	HSD3B7,CYP8B1,CYP7A1,SCP2,HSD17B4,CYP27A1,AKR1D1,ACOX2,AKR1C4,ACOT8,AMACR
hsa_M00087	beta-Oxidation	0.567453657273494	-0.566596194153117	12	11	0.00174603174603175	6300	7161	30,3030,3032,10449,3033,51,34,37,1962,33,8310	ACAA1,HADHA,HADHB,ACAA2,HADH,ACOX1,ACADM,ACADVL,EHHADH,ACADL,ACOX3
M00052	Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP	0.567453657273494	-0.566596194153117	12	11	0.00174603174603175	6300	7161	129607,29922,1503,51727,10201,4831,221264,654364,4830,4833,4832	CMPK2,NME7,CTPS1,CMPK1,NME6,NME2,AK9,NME1-NME2,NME1,NME4,NME3
hsa_M00052	Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP	0.567453657273494	-0.566596194153117	12	11	0.00174603174603175	6300	7161	4831,221264,654364,4830,4833,4832,129607,29922,1503,51727,10201	NME2,AK9,NME1-NME2,NME1,NME4,NME3,CMPK2,NME7,CTPS1,CMPK1,NME6
M00087	beta-Oxidation	0.567453657273494	-0.566596194153117	12	11	0.00174603174603175	6300	7161	30,51,37,8310,3032,3033,10449,3030,34,33,1962	ACAA1,ACOX1,ACADVL,ACOX3,HADHB,HADH,ACAA2,HADHA,ACADM,ACADL,EHHADH
hsa00230	Purine metabolism	0.576600756614399	-0.550605181578906	173	152	0.0241269841269841	6300	7161	84172,471,246721,51816,5315,51251,2766,107,2987,661,955,9533,5433,5432,55703,3000,548644,953,9615,272,5557,124583,5169,55276,2982,2983,9583,5441,10201,84265,5140,5148,112,3704,5167,5236,5439,221264,113,8833,4831,5147,10622,115,4860,9060,204,5151,109,30833,5427,318,5558,5430,51292,171568,5149,5136,22875,957,2977,654364,8622,84618,270,100,5142,51082,5143,646625,55821,4881,196883,6241,10714,108,51728,5424,271,122622,158,122481,58497,4907,10606,353,3615,111,5144,6240,1633,4830,5198,5138,1716,5158,5150,22978,10623,9061,2618,64425,25885,5145,5431,3614,221823,11128,87178,159,221830,50808,132,131870,5440,27115,56655,2984,56953,5313,57804,5146,5139,4882,5137,55811,114,7498,5141,23649,205,203,50940,55718,4832,4833,10846,50484,84284,5153,5152,5471,54107,956,11164,8654,26289,5434,93034,2272,53343,29922	POLR1B,ATIC,POLR2J2,ADA2,PKM,NT5C3A,GMPR,ADCY1,GUK1,POLR3D,ENTPD6,POLR1C,POLR2D,POLR2C,POLR3B,GUCY2D,POLR2J3,ENTPD1,GDA,AMPD3,PRIM1,CANT1,ENPP3,PGM2,GUCY1A1,GUCY1B1,ENTPD4,POLR2L,NME6,POLR3GL,PDE3B,PDE6G,ADCY6,ITPA,ENPP1,PGM1,POLR2J,AK9,ADCY7,GMPS,NME2,PDE6D,POLR3G,ADCY9,PNP,PAPSS2,AK2,PDE8A,ADCY3,NT5C,POLE2,NUDT2,PRIM2,POLR2A,GMPR2,POLR3H,PDE6H,PDE1A,ENPP4,ENTPD5,GUCY1A2,NME1-NME2,PDE8B,NT5C1A,AMPD1,ADA,PDE4B,POLR1D,PDE4C,URAD,ALLC,NPR1,ADCY4,RRM2,POLD3,ADCY2,POLR3K,POLD1,AMPD2,ADSS1,ADSL,AK7,PRUNE1,NT5E,PAICS,APRT,IMPDH2,ADCY5,PDE4D,RRM1,DCK,NME1,PFAS,PDE2A,DGUOK,PDE6B,PDE7A,NT5C2,POLR3C,PAPSS1,GART,POLR1E,POLR1A,PDE6A,POLR2B,IMPDH1,PRPS1L1,POLR3A,PNPT1,ADSS2,POLR1F,AK3,ADK,NUDT16,POLR2K,PDE7B,POLE4,GUCY2C,NT5M,PKLR,POLD4,PDE6C,PDE3A,NPR2,PDE1C,ADCY10,ADCY8,XDH,PDE4A,POLA2,AK4,AK1,PDE11A,POLR3E,NME3,NME4,PDE10A,RRM2B,NTPCR,PDE1B,PDE9A,PPAT,POLE3,ENTPD3,NUDT5,PDE5A,AK5,POLR2E,NT5C1B,FHIT,NUDT9,NME7
ko00230	Purine metabolism	0.576600756614399	-0.550605181578906	173	152	0.0241269841269841	6300	7161	55811,7498,114,4882,5137,205,5141,23649,203,50940,55718,5440,131870,27115,132,56655,57804,5313,56953,2984,5139,5146,54107,5471,11164,956,26289,5434,8654,53343,29922,93034,2272,10846,4832,4833,50484,5153,84284,5152,10606,4907,58497,5144,111,6240,353,3615,51728,122622,158,5424,271,122481,3614,221823,25885,5145,5431,11128,159,221830,87178,50808,4830,1633,5198,5138,5150,5158,22978,1716,9061,2618,64425,10623,318,30833,5427,51292,171568,5430,5558,5136,5149,957,22875,4831,10622,5147,221264,8833,113,9060,115,4860,5151,109,204,5142,51082,646625,5143,100,4881,196883,55821,6241,108,10714,2977,654364,8622,84618,270,661,955,2987,5433,9533,5432,55703,953,9615,3000,548644,471,84172,246721,51816,5315,51251,107,2766,5148,5140,112,3704,5167,5236,5439,5557,124583,272,9583,5441,5169,55276,2982,2983,10201,84265	ADCY10,XDH,ADCY8,NPR2,PDE1C,AK4,PDE4A,POLA2,AK1,PDE11A,POLR3E,POLR2K,NUDT16,PDE7B,ADK,POLE4,POLD4,PKLR,NT5M,GUCY2C,PDE3A,PDE6C,POLE3,PPAT,NUDT5,ENTPD3,AK5,POLR2E,PDE5A,NUDT9,NME7,NT5C1B,FHIT,PDE10A,NME3,NME4,RRM2B,PDE1B,NTPCR,PDE9A,PAICS,NT5E,PRUNE1,PDE4D,ADCY5,RRM1,APRT,IMPDH2,POLR3K,ADSS1,ADSL,POLD1,AMPD2,AK7,IMPDH1,PRPS1L1,POLR1A,PDE6A,POLR2B,POLR3A,ADSS2,POLR1F,PNPT1,AK3,NME1,DCK,PFAS,PDE2A,PDE7A,PDE6B,NT5C2,DGUOK,PAPSS1,GART,POLR1E,POLR3C,NUDT2,NT5C,POLE2,GMPR2,POLR3H,POLR2A,PRIM2,PDE1A,PDE6H,ENTPD5,ENPP4,NME2,POLR3G,PDE6D,AK9,GMPS,ADCY7,PAPSS2,ADCY9,PNP,PDE8A,ADCY3,AK2,PDE4B,POLR1D,URAD,PDE4C,ADA,NPR1,ADCY4,ALLC,RRM2,ADCY2,POLD3,GUCY1A2,NME1-NME2,PDE8B,NT5C1A,AMPD1,POLR3D,ENTPD6,GUK1,POLR2D,POLR1C,POLR2C,POLR3B,ENTPD1,GDA,GUCY2D,POLR2J3,ATIC,POLR1B,POLR2J2,ADA2,PKM,NT5C3A,ADCY1,GMPR,PDE6G,PDE3B,ADCY6,ITPA,ENPP1,PGM1,POLR2J,PRIM1,CANT1,AMPD3,ENTPD4,POLR2L,ENPP3,PGM2,GUCY1A1,GUCY1B1,NME6,POLR3GL
ko00310	Lysine degradation	0.584028810848799	-0.53780496372557	59	52	0.00825396825396825	6300	7161	29072,84193,2146,39,51166,84787,3033,79723,1962,80854,23067,9757,79709,219,387893,1743,55870,51111,56979,4967,123688,7799,8985,223,501,58508,7468,5351,3030,84444,224,10157,6419,217,5352,79823,2639,10919,8424,9869,55753,83852,55904,4297,93166,64324,38,2145,23127,85007,54904,51268	SETD2,SETD3,EZH2,ACAT2,AADAT,KMT5C,HADH,SUV39H2,EHHADH,SETD7,SETD1B,KMT2B,COLGALT1,ALDH1B1,KMT5A,DLST,ASH1L,KMT5B,PRDM9,OGDH,HYKK,PRDM2,PLOD3,ALDH9A1,ALDH7A1,KMT2C,NSD2,PLOD1,HADHA,DOT1L,ALDH3A2,AASS,SETMAR,ALDH2,PLOD2,CAMKMT,GCDH,EHMT2,BBOX1,SETDB1,OGDHL,SETDB2,KMT2E,KMT2A,PRDM6,NSD1,ACAT1,EZH1,COLGALT2,PHYKPL,NSD3,PIPOX
hsa00310	Lysine degradation	0.584028810848799	-0.53780496372557	59	52	0.00825396825396825	6300	7161	2145,38,51268,54904,85007,23127,55904,93166,64324,4297,10919,2639,79823,5352,83852,55753,9869,8424,217,6419,10157,224,84444,3030,501,5351,7468,58508,223,123688,8985,7799,51111,55870,4967,56979,1743,387893,219,79709,9757,23067,80854,79723,1962,3033,84787,51166,84193,29072,39,2146	EZH1,ACAT1,PIPOX,NSD3,PHYKPL,COLGALT2,KMT2E,PRDM6,NSD1,KMT2A,EHMT2,GCDH,CAMKMT,PLOD2,SETDB2,OGDHL,SETDB1,BBOX1,ALDH2,SETMAR,AASS,ALDH3A2,DOT1L,HADHA,ALDH7A1,PLOD1,NSD2,KMT2C,ALDH9A1,HYKK,PLOD3,PRDM2,KMT5B,ASH1L,OGDH,PRDM9,DLST,KMT5A,ALDH1B1,COLGALT1,KMT2B,SETD1B,SETD7,SUV39H2,EHHADH,HADH,KMT5C,AADAT,SETD3,SETD2,ACAT2,EZH2
ko05020	Prion diseases	0.585763942321547	-0.534838399365264	35	31	0.00492063492063492	6300	7161	5568,5594,5605,10963,714,3915,4684,6647,730,713,732,735,6352,3569,3552,5604,712,5595,3553,100506742,5621,5567,581,731,3309,2534,5566,4685,729,1958,727	PRKACG,MAPK1,MAP2K2,STIP1,C1QC,LAMC1,NCAM1,SOD1,C7,C1QB,C8B,C9,CCL5,IL6,IL1A,MAP2K1,C1QA,MAPK3,IL1B,CASP12,PRNP,PRKACB,BAX,C8A,HSPA5,FYN,PRKACA,NCAM2,C6,EGR1,C5
hsa05020	Prion diseases	0.585763942321547	-0.534838399365264	35	31	0.00492063492063492	6300	7161	735,6352,3569,712,3552,5595,5604,3553,5621,100506742,5567,581,731,3309,2534,5566,729,4685,727,1958,5568,5594,5605,10963,714,3915,4684,6647,730,713,732	C9,CCL5,IL6,C1QA,IL1A,MAPK3,MAP2K1,IL1B,PRNP,CASP12,PRKACB,BAX,C8A,HSPA5,FYN,PRKACA,C6,NCAM2,C5,EGR1,PRKACG,MAPK1,MAP2K2,STIP1,C1QC,LAMC1,NCAM1,SOD1,C7,C1QB,C8B
hsa04146	Peroxisome	0.586060241533504	-0.534332693437097	83	73	0.0115873015873016	6300	7161	6647,54511,5052,23417,5828,5825,51703,1384,5192,26061,1962,92960,4598,11001,51179,10455,189,3417,83594,5189,5191,373156,10478,25824,5824,6342,55825,51555,2181,847,3295,7498,570,10901,8504,1891,2053,23600,11264,10005,8540,55711,255027,5195,3155,2180,54363,10654,51,54677,26063,30,1610,8528,225,8800,84188,3418,390916,5264,84769,23305,283927,51268,9409,8443,8309,6648,5830,8310,5826,728635,55670	SOD1,HMGCLL1,PRDX1,MLYCD,PEX2,ABCD3,ACSL5,CRAT,PEX10,HACL1,EHHADH,PEX11G,MVK,SLC27A2,HAO2,ECI2,AGXT,IDH1,NUDT12,PEX1,PEX7,GSTK1,SLC25A17,PRDX5,PEX19,SCP2,PECR,PEX5L,ACSL3,CAT,HSD17B4,XDH,BAAT,DHRS4,PEX3,ECH1,EPHX2,AMACR,PXMP4,ACOT8,AGPS,FAR2,MPV17L,PEX14,HMGCL,ACSL1,HAO1,PMVK,ACOX1,CROT,DECR2,ACAA1,DAO,DDO,ABCD2,PEX11A,FAR1,IDH2,NUDT19,PHYH,MPV17L2,ACSL6,NUDT7,PIPOX,PEX16,GNPAT,ACOX2,SOD2,PEX5,ACOX3,ABCD4,DHRS4L1,PEX26
ko04146	Peroxisome	0.586060241533504	-0.534332693437097	83	73	0.0115873015873016	6300	7161	84769,5264,390916,3418,9409,51268,283927,23305,5830,8309,6648,8443,55670,728635,5826,8310,3155,5195,255027,55711,54363,2180,30,26063,54677,51,10654,84188,8800,225,8528,1610,10478,373156,5191,847,3295,51555,2181,55825,6342,5824,25824,570,7498,8540,11264,10005,23600,2053,1891,8504,10901,5192,51703,5825,1384,5828,23417,6647,5052,54511,11001,4598,92960,26061,1962,3417,189,51179,10455,5189,83594	MPV17L2,PHYH,NUDT19,IDH2,PEX16,PIPOX,NUDT7,ACSL6,PEX5,ACOX2,SOD2,GNPAT,PEX26,DHRS4L1,ABCD4,ACOX3,HMGCL,PEX14,MPV17L,FAR2,HAO1,ACSL1,ACAA1,DECR2,CROT,ACOX1,PMVK,FAR1,PEX11A,ABCD2,DDO,DAO,SLC25A17,GSTK1,PEX7,CAT,HSD17B4,PEX5L,ACSL3,PECR,SCP2,PEX19,PRDX5,BAAT,XDH,AGPS,PXMP4,ACOT8,AMACR,EPHX2,ECH1,PEX3,DHRS4,PEX10,ACSL5,ABCD3,CRAT,PEX2,MLYCD,SOD1,PRDX1,HMGCLL1,SLC27A2,MVK,PEX11G,HACL1,EHHADH,IDH1,AGXT,HAO2,ECI2,PEX1,NUDT12
hsa00053	Ascorbate and aldarate metabolism	0.588833066296541	-0.529612554352637	27	24	0.00380952380952381	6300	7161	224,54600,54490,223,10941,79799,7363,7365,501,54659,7366,54657,54575,54578,54579,7364,217,54577,219,574537,54576,7358,10720,54658	ALDH3A2,UGT1A9,UGT2B28,ALDH9A1,UGT2A1,UGT2A3,UGT2B4,UGT2B10,ALDH7A1,UGT1A3,UGT2B15,UGT1A4,UGT1A10,UGT1A6,UGT1A5,UGT2B7,ALDH2,UGT1A7,ALDH1B1,UGT2A2,UGT1A8,UGDH,UGT2B11,UGT1A1
hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	0.588833066296541	-0.529612554352637	27	24	0.00380952380952381	6300	7161	8706,10678,2524,10402,8707,28,2527,8704,79369,84002,2525,2528,6487,10331,10317,10690,2651,53947,6484,6489,2683,8702,8703,8708	B3GALNT1,B3GNT2,FUT2,ST3GAL6,B3GALT2,ABO,FUT5,B4GALT2,B3GNT4,B3GNT5,FUT3,FUT6,ST3GAL3,B3GNT3,B3GALT5,FUT9,GCNT2,A4GALT,ST3GAL4,ST8SIA1,B4GALT1,B4GALT4,B4GALT3,B3GALT1
hsa04966	Collecting duct acid secretion	0.588833066296541	-0.529612554352637	27	24	0.00380952380952381	6300	7161	760,8992,528,127124,1188,496,245972,90423,23545,155066,526,495,9550,9114,50617,535,10312,529,523,245973,51382,10723,6521,525	CA2,ATP6V0E1,ATP6V1C1,ATP6V1G3,CLCNKB,ATP4B,ATP6V0D2,ATP6V1E2,ATP6V0A2,ATP6V0E2,ATP6V1B2,ATP4A,ATP6V1G1,ATP6V0D1,ATP6V0A4,ATP6V0A1,TCIRG1,ATP6V1E1,ATP6V1A,ATP6V1C2,ATP6V1D,SLC12A7,SLC4A1,ATP6V1B1
ko00601	Glycosphingolipid biosynthesis - lacto and neolacto series	0.588833066296541	-0.529612554352637	27	24	0.00380952380952381	6300	7161	2528,8706,2525,84002,2651,10690,8707,28,10317,10331,10402,2524,6487,10678,2683,6489,8704,53947,6484,2527,79369,8708,8703,8702	FUT6,B3GALNT1,FUT3,B3GNT5,GCNT2,FUT9,B3GALT2,ABO,B3GALT5,B3GNT3,ST3GAL6,FUT2,ST3GAL3,B3GNT2,B4GALT1,ST8SIA1,B4GALT2,A4GALT,ST3GAL4,FUT5,B3GNT4,B3GALT1,B4GALT3,B4GALT4
ko04966	Collecting duct acid secretion	0.588833066296541	-0.529612554352637	27	24	0.00380952380952381	6300	7161	245972,90423,528,8992,760,496,1188,127124,526,23545,155066,535,9550,495,50617,9114,525,6521,10723,523,529,10312,51382,245973	ATP6V0D2,ATP6V1E2,ATP6V1C1,ATP6V0E1,CA2,ATP4B,CLCNKB,ATP6V1G3,ATP6V1B2,ATP6V0A2,ATP6V0E2,ATP6V0A1,ATP6V1G1,ATP4A,ATP6V0A4,ATP6V0D1,ATP6V1B1,SLC4A1,SLC12A7,ATP6V1A,ATP6V1E1,TCIRG1,ATP6V1D,ATP6V1C2
ko00053	Ascorbate and aldarate metabolism	0.588833066296541	-0.529612554352637	27	24	0.00380952380952381	6300	7161	7358,10720,54658,7364,54579,574537,219,54577,217,54576,54575,54578,7366,54659,54657,79799,7363,501,7365,54490,223,10941,224,54600	UGDH,UGT2B11,UGT1A1,UGT2B7,UGT1A5,UGT2A2,ALDH1B1,UGT1A7,ALDH2,UGT1A8,UGT1A10,UGT1A6,UGT2B15,UGT1A3,UGT1A4,UGT2A3,UGT2B4,ALDH7A1,UGT2B10,UGT2B28,ALDH9A1,UGT2A1,ALDH3A2,UGT1A9
hsa_M00341	Proteasome, 19S regulatory particle (PA700)	0.595430927213308	-0.518469888159781	19	17	0.0026984126984127	6300	7161	5700,5708,5702,5701,5710,5718,5713,10213,5714,5719,9861,5704,5717,5707,11047,5706,7979	PSMC1,PSMD2,PSMC3,PSMC2,PSMD4,PSMD12,PSMD7,PSMD14,PSMD8,PSMD13,PSMD6,PSMC4,PSMD11,PSMD1,ADRM1,PSMC6,SEM1
M00341	Proteasome, 19S regulatory particle (PA700)	0.595430927213308	-0.518469888159781	19	17	0.0026984126984127	6300	7161	5707,5717,5706,7979,11047,5713,5718,5701,5710,5702,5708,5700,5704,9861,5719,5714,10213	PSMD1,PSMD11,PSMC6,SEM1,ADRM1,PSMD7,PSMD12,PSMC2,PSMD4,PSMC3,PSMD2,PSMC1,PSMC4,PSMD6,PSMD13,PSMD8,PSMD14
hsa_M00110	C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	1588,3284,3283,1586	CYP19A1,HSD3B2,HSD3B1,CYP17A1
M00070	Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	10317,8707,84002,8708	B3GALT5,B3GALT2,B3GNT5,B3GALT1
hsa_M00148	Succinate dehydrogenase (ubiquinone)	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	6390,6389,6392,6391	SDHB,SDHA,SDHD,SDHC
M00148	Succinate dehydrogenase (ubiquinone)	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	6392,6390,6389,6391	SDHD,SDHB,SDHA,SDHC
M00690	MAPK (ERK5) signaling	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	4215,5607,5598,10746	MAP3K3,MAP2K5,MAPK7,MAP3K2
M00632	Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	2592,2582,130589,2584	GALT,GALE,GALM,GALK1
M00110	C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	3284,1588,1586,3283	HSD3B2,CYP19A1,CYP17A1,HSD3B1
hsa_M00401	Sec61 complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	55176,10952,29927,23480	SEC61A2,SEC61B,SEC61A1,SEC61G
hsa_M00685	Apoptotic machinery	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	840,836,317,842	CASP7,CASP3,APAF1,CASP9
M00393	TRAMP complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	11044,23517,64282,84186	TENT4A,MTREX,TENT4B,ZCCHC7
hsa_M00690	MAPK (ERK5) signaling	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	5598,5607,10746,4215	MAPK7,MAP2K5,MAP3K2,MAP3K3
M00401	Sec61 complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	23480,29927,55176,10952	SEC61G,SEC61A1,SEC61A2,SEC61B
M00381	SCF-SKP2 complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	8454,6500,6502,9978	CUL1,SKP1,SKP2,RBX1
hsa_M00027	GABA (gamma-Aminobutyrate) shunt	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	2571,18,7915,2572	GAD1,ABAT,ALDH5A1,GAD2
hsa_M00286	GINS complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	84296,9837,51659,64785	GINS4,GINS1,GINS2,GINS3
hsa_M00632	Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	2584,130589,2582,2592	GALK1,GALM,GALE,GALT
hsa_M00070	Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	10317,8707,84002,8708	B3GALT5,B3GALT2,B3GNT5,B3GALT1
hsa00290	Valine, leucine and isoleucine biosynthesis	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	10993,113675,586,587	SDS,SDSL,BCAT1,BCAT2
M00387	SCF-FBW7 complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	6500,8454,9978,55294	SKP1,CUL1,RBX1,FBXW7
hsa_M00015	Proline biosynthesis, glutamate => proline	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	29920,65263,5832,5831	PYCR2,PYCR3,ALDH18A1,PYCR1
M00015	Proline biosynthesis, glutamate => proline	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	65263,5832,29920,5831	PYCR3,ALDH18A1,PYCR2,PYCR1
hsa_M00741	Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	4594,5096,84693,5095	MMUT,PCCB,MCEE,PCCA
ko00290	Valine, leucine and isoleucine biosynthesis	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	586,113675,10993,587	BCAT1,SDSL,SDS,BCAT2
M00286	GINS complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	9837,84296,64785,51659	GINS1,GINS4,GINS3,GINS2
M00685	Apoptotic machinery	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	842,317,836,840	CASP9,APAF1,CASP3,CASP7
hsa_M00384	Cul3-SPOP complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	9978,339745,8405,8452	RBX1,SPOPL,SPOP,CUL3
M00133	Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	113451,6723,262,79814	AZIN2,SRM,AMD1,AGMAT
hsa_M00387	SCF-FBW7 complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	9978,55294,6500,8454	RBX1,FBXW7,SKP1,CUL1
hsa_M00133	Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	79814,262,6723,113451	AGMAT,AMD1,SRM,AZIN2
M00384	Cul3-SPOP complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	8452,8405,339745,9978	CUL3,SPOP,SPOPL,RBX1
M00027	GABA (gamma-Aminobutyrate) shunt	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	2571,18,7915,2572	GAD1,ABAT,ALDH5A1,GAD2
hsa_M00393	TRAMP complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	11044,23517,64282,84186	TENT4A,MTREX,TENT4B,ZCCHC7
hsa_M00381	SCF-SKP2 complex	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	8454,6500,6502,9978	CUL1,SKP1,SKP2,RBX1
M00741	Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA	0.598987493811086	-0.512514559530246	4	4	0.000634920634920635	6300	7161	4594,5096,84693,5095	MMUT,PCCB,MCEE,PCCA
ko00860	Porphyrin and chlorophyll metabolism	0.606911951867817	-0.499371553027571	42	37	0.00587301587301587	6300	7161	1352,10941,1355,54490,7363,2235,3145,7365,79799,54600,326625,210,2395,124454,54576,2990,7390,5498,54579,7364,54577,574537,10720,54658,1371,2058,54659,644,7366,54657,3163,3162,7389,54578,54575,1356,211	COX10,UGT2A1,COX15,UGT2B28,UGT2B4,FECH,HMBS,UGT2B10,UGT2A3,UGT1A9,MMAB,ALAD,FXN,EARS2,UGT1A8,GUSB,UROS,PPOX,UGT1A5,UGT2B7,UGT1A7,UGT2A2,UGT2B11,UGT1A1,CPOX,EPRS1,UGT1A3,BLVRA,UGT2B15,UGT1A4,HMOX2,HMOX1,UROD,UGT1A6,UGT1A10,CP,ALAS1
hsa00860	Porphyrin and chlorophyll metabolism	0.606911951867817	-0.499371553027571	42	37	0.00587301587301587	6300	7161	124454,2395,210,54600,326625,7365,7363,2235,3145,79799,10941,1355,1352,54490,54578,7389,54575,211,1356,54657,3163,3162,644,54659,7366,54658,1371,2058,10720,5498,54576,2990,7390,54577,574537,54579,7364	EARS2,FXN,ALAD,UGT1A9,MMAB,UGT2B10,UGT2B4,FECH,HMBS,UGT2A3,UGT2A1,COX15,COX10,UGT2B28,UGT1A6,UROD,UGT1A10,ALAS1,CP,UGT1A4,HMOX2,HMOX1,BLVRA,UGT1A3,UGT2B15,UGT1A1,CPOX,EPRS1,UGT2B11,PPOX,UGT1A8,GUSB,UROS,UGT1A7,UGT2A2,UGT1A5,UGT2B7
M00032	Lysine degradation, lysine => saccharopine => acetoacetyl-CoA	0.611663288504516	-0.491573330057728	11	10	0.00158730158730159	6300	7161	2639,501,1962,51166,1743,55753,3030,4967,3033,10157	GCDH,ALDH7A1,EHHADH,AADAT,DLST,OGDHL,HADHA,OGDH,HADH,AASS
hsa_M00032	Lysine degradation, lysine => saccharopine => acetoacetyl-CoA	0.611663288504516	-0.491573330057728	11	10	0.00158730158730159	6300	7161	51166,1962,1743,55753,2639,501,3030,10157,4967,3033	AADAT,EHHADH,DLST,OGDHL,GCDH,ALDH7A1,HADHA,AASS,OGDH,HADH
ko05332	Graft-versus-host disease	0.629471053012154	-0.462875410650105	41	36	0.00571428571428571	6300	7161	942,3107,3811,3802,3135,3106,3133,3127,940,5551,3112,3113,3118,356,7124,3109,3812,3117,3824,3134,941,3804,3821,355,3569,3458,3111,3108,3105,3552,3122,3123,3553,3119,3558,3002	CD86,HLA-C,KIR3DL1,KIR2DL1,HLA-G,HLA-B,HLA-E,HLA-DRB5,CD28,PRF1,HLA-DOB,HLA-DPA1,HLA-DQA2,FASLG,TNF,HLA-DMB,KIR3DL2,HLA-DQA1,KLRD1,HLA-F,CD80,KIR2DL3,KLRC1,FAS,IL6,IFNG,HLA-DOA,HLA-DMA,HLA-A,IL1A,HLA-DRA,HLA-DRB1,IL1B,HLA-DQB1,IL2,GZMB
ko03440	Homologous recombination	0.629471053012154	-0.462875410650105	41	36	0.00571428571428571	6300	7161	641,5889,4683,79728,57804,5424,11073,25788,8438,7979,6117,6119,50511,84142,5893,672,5892,5890,7156,29086,8940,472,4361,675,10111,5888,9577,580,51720,10714,6742,7516,6118,7517,83990,146956	BLM,RAD51C,NBN,PALB2,POLD4,POLD1,TOPBP1,RAD54B,RAD54L,SEM1,RPA1,RPA3,SYCP3,ABRAXAS1,RAD52,BRCA1,RAD51D,RAD51B,TOP3A,BABAM1,TOP3B,ATM,MRE11,BRCA2,RAD50,RAD51,BABAM2,BARD1,UIMC1,POLD3,SSBP1,XRCC2,RPA2,XRCC3,BRIP1,EME1
hsa03440	Homologous recombination	0.629471053012154	-0.462875410650105	41	36	0.00571428571428571	6300	7161	8940,472,4361,675,10111,5888,9577,580,51720,10714,6742,7516,6118,83990,7517,146956,641,4683,5889,79728,57804,5424,11073,25788,8438,7979,6117,6119,50511,84142,5893,672,5892,5890,7156,29086	TOP3B,ATM,MRE11,BRCA2,RAD50,RAD51,BABAM2,BARD1,UIMC1,POLD3,SSBP1,XRCC2,RPA2,BRIP1,XRCC3,EME1,BLM,NBN,RAD51C,PALB2,POLD4,POLD1,TOPBP1,RAD54B,RAD54L,SEM1,RPA1,RPA3,SYCP3,ABRAXAS1,RAD52,BRCA1,RAD51D,RAD51B,TOP3A,BABAM1
hsa05332	Graft-versus-host disease	0.629471053012154	-0.462875410650105	41	36	0.00571428571428571	6300	7161	356,3113,5551,3112,3118,7124,3109,3811,3802,3107,942,940,3127,3135,3106,3133,3569,3105,3111,3108,3458,355,3002,3123,3553,3552,3122,3558,3119,3117,3134,3824,3812,3821,941,3804	FASLG,HLA-DPA1,PRF1,HLA-DOB,HLA-DQA2,TNF,HLA-DMB,KIR3DL1,KIR2DL1,HLA-C,CD86,CD28,HLA-DRB5,HLA-G,HLA-B,HLA-E,IL6,HLA-A,HLA-DOA,HLA-DMA,IFNG,FAS,GZMB,HLA-DRB1,IL1B,IL1A,HLA-DRA,IL2,HLA-DQB1,HLA-DQA1,HLA-F,KLRD1,KIR3DL2,KLRC1,CD80,KIR2DL3
ko04215	Apoptosis - multiple species	0.635898811093351	-0.452715830354569	33	29	0.0046031746031746	6300	7161	330,7132,317,836,5414,27113,332,57448,842,56616,10018,4804,840,27429,5599,8772,5602,596,79444,54205,329,5366,581,8678,578,5601,112401,598,841	BIRC3,TNFRSF1A,APAF1,CASP3,SEPTIN4,BBC3,BIRC5,BIRC6,CASP9,DIABLO,BCL2L11,NGFR,CASP7,HTRA2,MAPK8,FADD,MAPK10,BCL2,BIRC7,CYCS,BIRC2,PMAIP1,BAX,BECN1,BAK1,MAPK9,BIRC8,BCL2L1,CASP8
hsa03410	Base excision repair	0.635898811093351	-0.452715830354569	33	29	0.0046031746031746	6300	7161	7515,4913,10039,142,56655,252969,3146,5424,2237,57804,3980,5427,6996,5111,10038,5423,3978,79661,23583,4595,4350,27343,4968,143,54107,10714,7374,8930,55247	XRCC1,NTHL1,PARP3,PARP1,POLE4,NEIL2,HMGB1,POLD1,FEN1,POLD4,LIG3,POLE2,TDG,PCNA,PARP2,POLB,LIG1,NEIL1,SMUG1,MUTYH,MPG,POLL,OGG1,PARP4,POLE3,POLD3,UNG,MBD4,NEIL3
ko03410	Base excision repair	0.635898811093351	-0.452715830354569	33	29	0.0046031746031746	6300	7161	57804,2237,5424,3146,252969,56655,4913,10039,142,7515,10038,5111,6996,5427,3980,4350,4595,23583,79661,3978,5423,55247,7374,8930,10714,54107,4968,143,27343	POLD4,FEN1,POLD1,HMGB1,NEIL2,POLE4,NTHL1,PARP3,PARP1,XRCC1,PARP2,PCNA,TDG,POLE2,LIG3,MPG,MUTYH,SMUG1,NEIL1,LIG1,POLB,NEIL3,UNG,MBD4,POLD3,POLE3,OGG1,PARP4,POLL
hsa04215	Apoptosis - multiple species	0.635898811093351	-0.452715830354569	33	29	0.0046031746031746	6300	7161	8678,578,112401,598,5601,841,79444,596,54205,5366,581,329,10018,57448,842,56616,27429,5599,4804,840,8772,5602,330,5414,836,7132,317,27113,332	BECN1,BAK1,BIRC8,BCL2L1,MAPK9,CASP8,BIRC7,BCL2,CYCS,PMAIP1,BAX,BIRC2,BCL2L11,BIRC6,CASP9,DIABLO,HTRA2,MAPK8,NGFR,CASP7,FADD,MAPK10,BIRC3,SEPTIN4,CASP3,TNFRSF1A,APAF1,BBC3,BIRC5
ko04330	Notch signaling pathway	0.645837025789845	-0.43720808908707	48	42	0.00666666666666667	6300	7161	9794,1857,182,23220,51107,4854,9253,1856,1488,5664,8850,171558,55534,23385,113878,3065,8650,2033,3714,22938,9612,388585,54567,9541,5986,196403,4242,5663,84441,10683,4855,4853,1840,3955,83464,3066,6868,3516,1855,1387,3280,1487	MAML1,DVL3,JAG1,DTX4,APH1A,NOTCH3,NUMBL,DVL2,CTBP2,PSEN2,KAT2B,PTCRA,MAML3,NCSTN,DTX2,HDAC1,NUMB,EP300,JAG2,SNW1,NCOR2,HES5,DLL4,CIR1,RFNG,DTX3,MFNG,PSEN1,MAML2,DLL3,NOTCH4,NOTCH2,DTX1,LFNG,APH1B,HDAC2,ADAM17,RBPJ,DVL1,CREBBP,HES1,CTBP1
hsa04330	Notch signaling pathway	0.645837025789845	-0.43720808908707	48	42	0.00666666666666667	6300	7161	1856,1488,5664,8850,171558,55534,23385,3065,113878,9794,1857,182,23220,51107,9253,4854,22938,3714,9612,388585,54567,8650,2033,4855,10683,4853,1840,3955,9541,5986,196403,4242,5663,84441,1387,3280,1487,3066,83464,6868,3516,1855	DVL2,CTBP2,PSEN2,KAT2B,PTCRA,MAML3,NCSTN,HDAC1,DTX2,MAML1,DVL3,JAG1,DTX4,APH1A,NUMBL,NOTCH3,SNW1,JAG2,NCOR2,HES5,DLL4,NUMB,EP300,NOTCH4,DLL3,NOTCH2,DTX1,LFNG,CIR1,RFNG,DTX3,MFNG,PSEN1,MAML2,CREBBP,HES1,CTBP1,HDAC2,APH1B,ADAM17,RBPJ,DVL1
hsa00062	Fatty acid elongation	0.646184718587237	-0.436669873987675	25	22	0.00349206349206349	6300	7161	5538,79071,51495,10965,6785,64834,122970,9200,201562,51102,401494,9524,83401,54898,60481,51144,3032,3033,10449,3030,79993,11332	PPT1,ELOVL6,HACD3,ACOT2,ELOVL4,ELOVL1,ACOT4,HACD1,HACD2,MECR,HACD4,TECR,ELOVL3,ELOVL2,ELOVL5,HSD17B12,HADHB,HADH,ACAA2,HADHA,ELOVL7,ACOT7
ko00062	Fatty acid elongation	0.646184718587237	-0.436669873987675	25	22	0.00349206349206349	6300	7161	79071,51495,9200,64834,201562,60481,54898,3033,3032,3030,11332,5538,6785,10965,122970,51102,9524,401494,83401,51144,10449,79993	ELOVL6,HACD3,HACD1,ELOVL1,HACD2,ELOVL5,ELOVL2,HADH,HADHB,HADHA,ACOT7,PPT1,ELOVL4,ACOT2,ACOT4,MECR,TECR,HACD4,ELOVL3,HSD17B12,ACAA2,ELOVL7
ko04623	Cytosolic DNA-sensing pathway	0.65610688514182	-0.421431568643051	63	55	0.00873015873015873	6300	7161	834,3553,55703,23586,9533,11035,3452,661,4790,81030,388372,3443,3442,90865,51728,340061,3606,115004,3551,9447,9641,11128,3439,29110,84265,29108,10623,3665,5970,3456,3441,5441,3449,55718,171568,3569,6352,57506,4793,4792,103,3448,3440,3445,3661,10622,5440,3627,8737,5434,11277,51082,6351,1147,3444	CASP1,IL1B,POLR3B,RIGI,POLR1C,RIPK3,IFNA21,POLR3D,NFKB1,ZBP1,CCL4L1,IFNA6,IFNA5,IL33,POLR3K,STING1,IL18,CGAS,IKBKB,AIM2,IKBKE,POLR3A,IFNA1,TBK1,POLR3GL,PYCARD,POLR3C,IRF7,RELA,IFNB1,IFNA4,POLR2L,IFNA16,POLR3E,POLR3H,IL6,CCL5,MAVS,NFKBIB,NFKBIA,ADAR,IFNA14,IFNA2,IFNA8,IRF3,POLR3G,POLR2K,CXCL10,RIPK1,POLR2E,TREX1,POLR1D,CCL4,CHUK,IFNA7
hsa04623	Cytosolic DNA-sensing pathway	0.65610688514182	-0.421431568643051	63	55	0.00873015873015873	6300	7161	3442,3443,90865,340061,3606,51728,115004,834,55703,23586,3553,11035,9533,3452,661,4790,388372,81030,84265,29108,3665,10623,5970,3441,3456,5441,3449,3551,9447,9641,11128,3439,29110,103,3445,3448,3440,3661,10622,3627,5440,8737,55718,171568,6352,3569,4792,57506,4793,1147,3444,5434,11277,6351,51082	IFNA5,IFNA6,IL33,STING1,IL18,POLR3K,CGAS,CASP1,POLR3B,RIGI,IL1B,RIPK3,POLR1C,IFNA21,POLR3D,NFKB1,CCL4L1,ZBP1,POLR3GL,PYCARD,IRF7,POLR3C,RELA,IFNA4,IFNB1,POLR2L,IFNA16,IKBKB,AIM2,IKBKE,POLR3A,IFNA1,TBK1,ADAR,IFNA8,IFNA14,IFNA2,IRF3,POLR3G,CXCL10,POLR2K,RIPK1,POLR3E,POLR3H,CCL5,IL6,NFKBIA,MAVS,NFKBIB,CHUK,IFNA7,POLR2E,TREX1,CCL4,POLR1D
hsa_M00426	Survival motor neuron (SMN) complex	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	79760,6607,25929,11218,11171,79833,8487,6606,50628	GEMIN7,SMN2,GEMIN5,DDX20,STRAP,GEMIN6,GEMIN2,SMN1,GEMIN4
M00059	Glycosaminoglycan biosynthesis, heparan sulfate backbone	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	2137,26035,2131,2132,64579,3340,9348,2135,2134	EXTL3,GLCE,EXT1,EXT2,NDST4,NDST1,NDST3,EXTL2,EXTL1
hsa_M00413	FA core complex	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	80233,2175,2188,2178,57697,55120,91442,2176,2189	FAAP100,FANCA,FANCF,FANCE,FANCM,FANCL,FAAP24,FANCC,FANCG
ko00072	Synthesis and degradation of ketone bodies	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	3155,54511,64064,3157,39,56898,622,5019,38	HMGCL,HMGCLL1,OXCT2,HMGCS1,ACAT2,BDH2,BDH1,OXCT1,ACAT1
hsa_M00693	Cell cycle - G2/M transition	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	983,995,8900,494551,891,9133,1017,7465,890	CDK1,CDC25C,CCNA1,WEE2,CCNB1,CCNB2,CDK2,WEE1,CCNA2
M00693	Cell cycle - G2/M transition	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	890,7465,1017,891,9133,8900,494551,983,995	CCNA2,WEE1,CDK2,CCNB1,CCNB2,CCNA1,WEE2,CDK1,CDC25C
M00035	Methionine degradation	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	4144,10768,1788,875,191,1786,4143,27430,23382	MAT2A,AHCYL1,DNMT3A,CBS,AHCY,DNMT1,MAT1A,MAT2B,AHCYL2
hsa_M00035	Methionine degradation	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	10768,4144,1788,1786,191,875,23382,27430,4143	AHCYL1,MAT2A,DNMT3A,DNMT1,AHCY,CBS,AHCYL2,MAT2B,MAT1A
hsa_M00059	Glycosaminoglycan biosynthesis, heparan sulfate backbone	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	2134,26035,2137,2131,2132,64579,3340,2135,9348	EXTL1,GLCE,EXTL3,EXT1,EXT2,NDST4,NDST1,EXTL2,NDST3
M00426	Survival motor neuron (SMN) complex	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	79833,11171,25929,11218,79760,6607,50628,6606,8487	GEMIN6,STRAP,GEMIN5,DDX20,GEMIN7,SMN2,GEMIN4,SMN1,GEMIN2
M00413	FA core complex	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	2176,2189,80233,2178,2188,2175,55120,91442,57697	FANCC,FANCG,FAAP100,FANCE,FANCF,FANCA,FANCL,FAAP24,FANCM
hsa00072	Synthesis and degradation of ketone bodies	0.657341654895752	-0.419551372990081	10	9	0.00142857142857143	6300	7161	3155,622,39,56898,3157,64064,54511,38,5019	HMGCL,BDH1,ACAT2,BDH2,HMGCS1,OXCT2,HMGCLL1,ACAT1,OXCT1
hsa04136	Autophagy - other	0.660969213851507	-0.41404801532629	32	28	0.00444444444444444	6300	7161	9140,5516,60673,55054,9474,26100,57521,11337,55062,64223,84971,23130,2475,9706,55102,84938,64422,83734,8678,5289,9776,23710,285973,10533,79065,11345,5515,30849	ATG12,PPP2CB,ATG101,ATG16L1,ATG5,WIPI2,RPTOR,GABARAP,WIPI1,MLST8,ATG4D,ATG2A,MTOR,ULK2,ATG2B,ATG4C,ATG3,ATG10,BECN1,PIK3C3,ATG13,GABARAPL1,ATG9B,ATG7,ATG9A,GABARAPL2,PPP2CA,PIK3R4
ko04136	Autophagy - other	0.660969213851507	-0.41404801532629	32	28	0.00444444444444444	6300	7161	9776,23710,83734,5289,8678,11345,30849,5515,285973,79065,10533,57521,9474,26100,11337,55062,9140,5516,60673,55054,84938,64422,23130,64223,84971,2475,55102,9706	ATG13,GABARAPL1,ATG10,PIK3C3,BECN1,GABARAPL2,PIK3R4,PPP2CA,ATG9B,ATG9A,ATG7,RPTOR,ATG5,WIPI2,GABARAP,WIPI1,ATG12,PPP2CB,ATG101,ATG16L1,ATG4C,ATG3,ATG2A,MLST8,ATG4D,MTOR,ATG2B,ULK2
hsa00360	Phenylalanine metabolism	0.664372752705406	-0.40891191246112	17	15	0.00238095238095238	6300	7161	3242,1644,259307,6898,8639,314,2805,2806,220,221,218,5053,10249,4282,222	HPD,DDC,IL4I1,TAT,AOC3,AOC2,GOT1,GOT2,ALDH1A3,ALDH3B1,ALDH3A1,PAH,GLYAT,MIF,ALDH3B2
ko00910	Nitrogen metabolism	0.664372752705406	-0.40891191246112	17	15	0.00238095238095238	6300	7161	767,763,23632,766,377677,765,2752,762,759,768,771,2746,761,760,1373	CA8,CA5A,CA14,CA7,CA13,CA6,GLUL,CA4,CA1,CA9,CA12,GLUD1,CA3,CA2,CPS1
ko00360	Phenylalanine metabolism	0.664372752705406	-0.40891191246112	17	15	0.00238095238095238	6300	7161	8639,314,2805,1644,3242,259307,6898,218,5053,10249,4282,222,2806,220,221	AOC3,AOC2,GOT1,DDC,HPD,IL4I1,TAT,ALDH3A1,PAH,GLYAT,MIF,ALDH3B2,GOT2,ALDH1A3,ALDH3B1
hsa00910	Nitrogen metabolism	0.664372752705406	-0.40891191246112	17	15	0.00238095238095238	6300	7161	761,760,1373,759,768,762,2752,2746,771,766,23632,765,377677,767,763	CA3,CA2,CPS1,CA1,CA9,CA4,GLUL,GLUD1,CA12,CA7,CA14,CA6,CA13,CA8,CA5A
ko00260	Glycine, serine and threonine metabolism	0.674367336233888	-0.393980307284338	39	34	0.0053968253968254	6300	7161	5223,132158,8639,875,189,1757,64902,314,29958,1610,2653,501,2731,2593,9380,10993,63826,5723,23464,1491,6470,275,5224,113675,635,6472,27232,2628,55349,211,29968,669,51268,1738	PGAM1,GLYCTK,AOC3,CBS,AGXT,SARDH,AGXT2,AOC2,DMGDH,DAO,GCSH,ALDH7A1,GLDC,GAMT,GRHPR,SDS,SRR,PSPH,GCAT,CTH,SHMT1,AMT,PGAM2,SDSL,BHMT,SHMT2,GNMT,GATM,CHDH,ALAS1,PSAT1,BPGM,PIPOX,DLD
hsa00260	Glycine, serine and threonine metabolism	0.674367336233888	-0.393980307284338	39	34	0.0053968253968254	6300	7161	2628,27232,1738,29968,55349,211,51268,669,5723,63826,5224,6470,275,6472,635,113675,1491,23464,2593,10993,9380,1757,189,29958,314,64902,8639,132158,5223,875,2731,501,1610,2653	GATM,GNMT,DLD,PSAT1,CHDH,ALAS1,PIPOX,BPGM,PSPH,SRR,PGAM2,SHMT1,AMT,SHMT2,BHMT,SDSL,CTH,GCAT,GAMT,SDS,GRHPR,SARDH,AGXT,DMGDH,AOC2,AGXT2,AOC3,GLYCTK,PGAM1,CBS,GLDC,ALDH7A1,DAO,GCSH
hsa04630	Jak-STAT signaling pathway	0.676588553599608	-0.390691940308032	156	136	0.0215873015873016	6300	7161	5777,598,282616,3575,53342,3586,116379,3601,282618,6774,122809,3717,29949,85480,9063,3442,3443,6655,7297,3460,9021,8503,2670,3574,338376,3560,5296,3568,53833,6654,5291,3265,3449,1270,10254,3596,3456,6775,30837,595,4170,6776,3595,3455,3569,3976,5295,50615,3467,2688,3567,3440,9466,3448,3718,2690,3594,3454,3562,2056,5618,5008,3587,3570,3578,3592,3593,3452,1439,50604,9180,207,2885,9306,5292,5771,5293,8835,1437,1026,316,51588,10379,3716,1441,3559,3439,8651,5894,8027,3459,1387,3565,894,1489,3953,3952,3441,4352,4609,2475,6778,1154,2033,3977,56832,3458,3590,59067,3572,50616,3558,6777,896,149233,5290,3566,596,9655,163702,53832,1271,3445,11009,5781,58985,3600,3444,10000,3588,5617,208,2057,8554,6773,6772	PTPN6,BCL2L1,IFNL2,IL7R,IL17D,IL10,IL22RA2,IL15RA,IFNL1,STAT3,SOCS4,JAK2,IL19,TSLP,PIAS2,IFNA5,IFNA6,SOS2,TYK2,IFNGR2,SOCS3,PIK3R3,GFAP,IL7,IFNE,IL2RB,PIK3R2,IL5RA,IL20RB,SOS1,PIK3CB,HRAS,IFNA16,CNTF,STAM2,IL13,IFNB1,STAT4,SOCS7,CCND1,MCL1,STAT5A,IL12RB2,IFNAR2,IL6,LIF,PIK3R1,IL21R,IFNW1,GH1,IL5,IFNA2,IL27RA,IFNA14,JAK3,GHR,IL12RB1,IFNAR1,IL3,EPO,PRLR,OSM,IL10RA,IL6R,IL9,IL12A,IL12B,IFNA21,CSF2RB,IL20,OSMR,AKT1,GRB2,SOCS6,PIM1,PTPN2,PIK3CD,SOCS2,CSF2,CDKN1A,AOX1,PIAS4,IRF9,JAK1,CSF3R,IL2RA,IFNA1,SOCS1,RAF1,STAM,IFNGR1,CREBBP,IL4,CCND2,CTF1,LEPR,LEP,IFNA4,MPL,MYC,MTOR,STAT6,CISH,EP300,LIFR,IFNK,IFNG,IL11RA,IL21,IL6ST,IL22,IL2,STAT5B,CCND3,IL23R,PIK3CA,IL4R,BCL2,SOCS5,IFNLR1,IL20RA,CNTFR,IFNA8,IL24,PTPN11,IL22RA1,IL15,IFNA7,AKT3,IL10RB,PRL,AKT2,EPOR,PIAS1,STAT2,STAT1
ko04630	Jak-STAT signaling pathway	0.676588553599608	-0.390691940308032	156	136	0.0215873015873016	6300	7161	6777,896,50616,3558,59067,3572,3458,3590,56832,2033,3977,3445,11009,1271,9655,163702,53832,596,149233,3566,5290,3600,58985,5781,6773,6772,8554,208,2057,5617,3588,3444,10000,9306,2885,50604,9180,207,3592,1439,3593,3452,3578,3570,3587,5618,5008,3716,10379,1441,1026,316,51588,1437,8835,5292,5771,5293,3565,1387,3459,5894,8027,3439,3559,8651,1154,6778,3441,4609,4352,2475,3953,3952,894,1489,3976,3569,3595,3455,4170,6776,3448,3440,9466,3567,2688,50615,3467,5295,3562,3594,3454,2690,3718,2056,3601,116379,3586,53342,3575,282616,598,5777,3442,6655,3443,9063,29949,85480,122809,3717,6774,282618,3568,3560,5296,3574,338376,2670,8503,9021,3460,7297,595,30837,6775,3596,3456,10254,1270,3449,5291,3265,6654,53833	STAT5B,CCND3,IL22,IL2,IL21,IL6ST,IFNG,IL11RA,IFNK,EP300,LIFR,IFNA8,IL24,CNTFR,SOCS5,IFNLR1,IL20RA,BCL2,IL23R,IL4R,PIK3CA,IL15,IL22RA1,PTPN11,STAT2,STAT1,PIAS1,AKT2,EPOR,PRL,IL10RB,IFNA7,AKT3,SOCS6,GRB2,IL20,OSMR,AKT1,IL12A,CSF2RB,IL12B,IFNA21,IL9,IL6R,IL10RA,PRLR,OSM,JAK1,IRF9,CSF3R,CDKN1A,AOX1,PIAS4,CSF2,SOCS2,PIM1,PTPN2,PIK3CD,IL4,CREBBP,IFNGR1,RAF1,STAM,IFNA1,IL2RA,SOCS1,CISH,STAT6,IFNA4,MYC,MPL,MTOR,LEPR,LEP,CCND2,CTF1,LIF,IL6,IL12RB2,IFNAR2,MCL1,STAT5A,IFNA14,IFNA2,IL27RA,IL5,GH1,IL21R,IFNW1,PIK3R1,IL3,IL12RB1,IFNAR1,GHR,JAK3,EPO,IL15RA,IL22RA2,IL10,IL17D,IL7R,IFNL2,BCL2L1,PTPN6,IFNA5,SOS2,IFNA6,PIAS2,IL19,TSLP,SOCS4,JAK2,STAT3,IFNL1,IL5RA,IL2RB,PIK3R2,IL7,IFNE,GFAP,PIK3R3,SOCS3,IFNGR2,TYK2,CCND1,SOCS7,STAT4,IL13,IFNB1,STAM2,CNTF,IFNA16,PIK3CB,HRAS,SOS1,IL20RB
M00107	Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	3283,1583,3284	HSD3B1,CYP11A1,HSD3B2
hsa_M00400	p97-Ufd1-Npl4 complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	7415,7353,55666	VCP,UFD1,NPLOC4
M00408	ESCRT-0 complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	10254,8027,9146	STAM2,STAM,HGS
M00132	Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	253430,3705,64768	IPMK,ITPK1,IPPK
M00134	Polyamine biosynthesis, arginine => ornithine => putrescine	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	383,4953,384	ARG1,ODC1,ARG2
hsa_M00051	Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	1723,7372,790	DHODH,UMPS,CAD
hsa00785	Lipoic acid metabolism	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	387787,51601,11019	LIPT2,LIPT1,LIAS
M00118	Glutathione biosynthesis, glutamate => glutathione	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	2937,2730,2729	GSS,GCLM,GCLC
M00051	Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	7372,1723,790	UMPS,DHODH,CAD
hsa_M00132	Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	64768,3705,253430	IPPK,ITPK1,IPMK
M00291	MRN complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	4361,4683,10111	MRE11,NBN,RAD50
hsa_M00069	Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	8869,29906,6489	ST3GAL5,ST8SIA5,ST8SIA1
hsa_M00410	ESCRT-II complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	11267,51028,84313	SNF8,VPS36,VPS25
hsa_M00107	Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	3283,1583,3284	HSD3B1,CYP11A1,HSD3B2
M00400	p97-Ufd1-Npl4 complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	55666,7353,7415	NPLOC4,UFD1,VCP
hsa_M00100	Sphingosine degradation	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	8877,8879,56848	SPHK1,SGPL1,SPHK2
hsa_M00082	Fatty acid biosynthesis, initiation	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	27349,31,2194	MCAT,ACACA,FASN
hsa00780	Biotin metabolism	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	686,54995,3141	BTD,OXSM,HLCS
hsa_M00108	C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	1584,1585,1589	CYP11B1,CYP11B2,CYP21A2
ko00780	Biotin metabolism	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	686,3141,54995	BTD,HLCS,OXSM
M00108	C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	1584,1585,1589	CYP11B1,CYP11B2,CYP21A2
M00069	Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	6489,29906,8869	ST8SIA1,ST8SIA5,ST3GAL5
hsa_M00297	DNA-PK complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	5591,7520,2547	PRKDC,XRCC5,XRCC6
M00410	ESCRT-II complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	51028,84313,11267	VPS36,VPS25,SNF8
M00046	Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	1806,51733,1807	DPYD,UPB1,DPYS
M00082	Fatty acid biosynthesis, initiation	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	31,2194,27349	ACACA,FASN,MCAT
hsa_M00291	MRN complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	10111,4683,4361	RAD50,NBN,MRE11
M00297	DNA-PK complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	5591,2547,7520	PRKDC,XRCC6,XRCC5
hsa_M00134	Polyamine biosynthesis, arginine => ornithine => putrescine	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	4953,383,384	ODC1,ARG1,ARG2
ko00785	Lipoic acid metabolism	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	387787,11019,51601	LIPT2,LIAS,LIPT1
hsa_M00408	ESCRT-0 complex	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	10254,9146,8027	STAM2,HGS,STAM
hsa_M00046	Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	1806,51733,1807	DPYD,UPB1,DPYS
M00100	Sphingosine degradation	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	8877,56848,8879	SPHK1,SPHK2,SGPL1
hsa_M00118	Glutathione biosynthesis, glutamate => glutathione	0.68088811825785	-0.38435727670003	3	3	0.000476190476190476	6300	7161	2729,2937,2730	GCLC,GSS,GCLM
ko01523	Antifolate resistance	0.685899237540195	-0.377024546096965	31	27	0.00428571428571429	6300	7161	3569,1244,4790,6472,6470,3553,10057,7298,200895,471,9429,8714,4363,10257,4524,7124,3551,1719,390243,8836,2348,239,2350,2352,2618,1147,5970	IL6,ABCC2,NFKB1,SHMT2,SHMT1,IL1B,ABCC5,TYMS,DHFR2,ATIC,ABCG2,ABCC3,ABCC1,ABCC4,MTHFR,TNF,IKBKB,DHFR,IZUMO1R,GGH,FOLR1,ALOX12,FOLR2,FOLR3,GART,CHUK,RELA
hsa01523	Antifolate resistance	0.685899237540195	-0.377024546096965	31	27	0.00428571428571429	6300	7161	4790,1244,3569,3553,6470,6472,471,9429,8714,200895,10057,7298,10257,4363,4524,2348,8836,390243,1719,3551,7124,2352,2350,239,5970,1147,2618	NFKB1,ABCC2,IL6,IL1B,SHMT1,SHMT2,ATIC,ABCG2,ABCC3,DHFR2,ABCC5,TYMS,ABCC4,ABCC1,MTHFR,FOLR1,GGH,IZUMO1R,DHFR,IKBKB,TNF,FOLR3,FOLR2,ALOX12,RELA,CHUK,GART
hsa04964	Proximal tubule bicarbonate reclamation	0.703535421350466	-0.351637053516875	23	20	0.00317460317460317	6300	7161	358,478,483,486,2744,6550,8671,482,760,27165,477,5105,480,762,1468,476,10991,481,4190,2746	AQP1,ATP1A3,ATP1B3,FXYD2,GLS,SLC9A3,SLC4A4,ATP1B2,CA2,GLS2,ATP1A2,PCK1,ATP1A4,CA4,SLC25A10,ATP1A1,SLC38A3,ATP1B1,MDH1,GLUD1
ko03430	Mismatch repair	0.703535421350466	-0.351637053516875	23	20	0.00317460317460317	6300	7161	10714,4436,27030,6119,5981,9156,5983,5982,5111,6742,5985,5984,6118,4292,5395,5424,57804,3978,2956,6117	POLD3,MSH2,MLH3,RPA3,RFC1,EXO1,RFC3,RFC2,PCNA,SSBP1,RFC5,RFC4,RPA2,MLH1,PMS2,POLD1,POLD4,LIG1,MSH6,RPA1
ko04964	Proximal tubule bicarbonate reclamation	0.703535421350466	-0.351637053516875	23	20	0.00317460317460317	6300	7161	480,762,1468,476,10991,481,4190,2746,6550,8671,482,760,477,27165,5105,486,2744,358,483,478	ATP1A4,CA4,SLC25A10,ATP1A1,SLC38A3,ATP1B1,MDH1,GLUD1,SLC9A3,SLC4A4,ATP1B2,CA2,ATP1A2,GLS2,PCK1,FXYD2,GLS,AQP1,ATP1B3,ATP1A3
hsa03430	Mismatch repair	0.703535421350466	-0.351637053516875	23	20	0.00317460317460317	6300	7161	6117,2956,3978,5424,57804,5395,5984,4292,6118,5111,5982,5983,9156,5985,6742,4436,27030,10714,5981,6119	RPA1,MSH6,LIG1,POLD1,POLD4,PMS2,RFC4,MLH1,RPA2,PCNA,RFC2,RFC3,EXO1,RFC5,SSBP1,MSH2,MLH3,POLD3,RFC1,RPA3
hsa_M00076	Dermatan sulfate degradation	0.704064699760586	-0.350885023977909	9	8	0.00126984126984127	6300	7161	8692,3425,3373,411,23553,8372,6677,2990	HYAL2,IDUA,HYAL1,ARSB,HYAL4,HYAL3,SPAM1,GUSB
hsa_M00361	Nucleotide sugar biosynthesis, eukaryotes	0.704064699760586	-0.350885023977909	9	8	0.00126984126984127	6300	7161	80146,6675,29925,2592,2582,7358,29926,7360	UXS1,UAP1,GMPPB,GALT,GALE,UGDH,GMPPA,UGP2
hsa_M00131	Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	0.704064699760586	-0.350885023977909	9	8	0.00126984126984127	6300	7161	54928,27124,3628,3612,3613,51763,8821,3631	BPNT2,INPP5J,INPP1,IMPA1,IMPA2,INPP5K,INPP4B,INPP4A
M00131	Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	0.704064699760586	-0.350885023977909	9	8	0.00126984126984127	6300	7161	27124,3628,54928,3613,3612,8821,51763,3631	INPP5J,INPP1,BPNT2,IMPA2,IMPA1,INPP4B,INPP5K,INPP4A
M00361	Nucleotide sugar biosynthesis, eukaryotes	0.704064699760586	-0.350885023977909	9	8	0.00126984126984127	6300	7161	29926,7360,7358,2592,2582,80146,6675,29925	GMPPA,UGP2,UGDH,GALT,GALE,UXS1,UAP1,GMPPB
M00076	Dermatan sulfate degradation	0.704064699760586	-0.350885023977909	9	8	0.00126984126984127	6300	7161	23553,8372,411,2990,6677,8692,3425,3373	HYAL4,HYAL3,ARSB,GUSB,SPAM1,HYAL2,IDUA,HYAL1
hsa03050	Proteasome	0.706699037185073	-0.347150393695945	45	39	0.00619047619047619	6300	7161	122706,5702,5708,5700,5720,3458,5719,5684,9861,5714,10213,5687,51371,5717,5695,5698,10197,5690,5692,5693,7979,5686,23198,5713,9491,5710,5701,5718,5685,5682,5704,5696,143471,5691,5707,5706,5694,5699,11047	PSMB11,PSMC3,PSMD2,PSMC1,PSME1,IFNG,PSMD13,PSMA3,PSMD6,PSMD8,PSMD14,PSMA6,POMP,PSMD11,PSMB7,PSMB9,PSME3,PSMB2,PSMB4,PSMB5,SEM1,PSMA5,PSME4,PSMD7,PSMF1,PSMD4,PSMC2,PSMD12,PSMA4,PSMA1,PSMC4,PSMB8,PSMA8,PSMB3,PSMD1,PSMC6,PSMB6,PSMB10,ADRM1
ko00565	Ether lipid metabolism	0.706699037185073	-0.347150393695945	45	39	0.00619047619047619	6300	7161	100137049,5168,26279,8613,8398,8612,122618,5321,54947,5051,50487,7941,11145,391013,8540,5049,123745,5338,23646,30814,255189,133121,64600,5319,5320,5322,9514,5337,8605,8611,151056,5048,283748,79888,7368,56994,84647,81579,10390	PLA2G4B,ENPP2,PLA2G2D,PLPP3,PLA2G6,PLPP2,PLD4,PLA2G4A,LPCAT2,PAFAH2,PLA2G3,PLA2G7,PLAAT3,PLA2G2C,AGPS,PAFAH1B2,PLA2G4E,PLD2,PLD3,PLA2G2E,PLA2G4F,ENPP6,PLA2G2F,PLA2G1B,PLA2G2A,PLA2G5,GAL3ST1,PLD1,PLA2G4C,PLPP1,PLB1,PAFAH1B1,PLA2G4D,LPCAT1,UGT8,CHPT1,PLA2G12B,PLA2G12A,CEPT1
hsa00565	Ether lipid metabolism	0.706699037185073	-0.347150393695945	45	39	0.00619047619047619	6300	7161	8612,8398,8613,122618,5321,5051,54947,50487,100137049,26279,5168,123745,5049,23646,5338,11145,7941,8540,391013,5320,5319,9514,5322,5337,8611,151056,8605,30814,255189,133121,64600,81579,10390,5048,283748,79888,56994,7368,84647	PLPP2,PLA2G6,PLPP3,PLD4,PLA2G4A,PAFAH2,LPCAT2,PLA2G3,PLA2G4B,PLA2G2D,ENPP2,PLA2G4E,PAFAH1B2,PLD3,PLD2,PLAAT3,PLA2G7,AGPS,PLA2G2C,PLA2G2A,PLA2G1B,GAL3ST1,PLA2G5,PLD1,PLPP1,PLB1,PLA2G4C,PLA2G2E,PLA2G4F,ENPP6,PLA2G2F,PLA2G12A,CEPT1,PAFAH1B1,PLA2G4D,LPCAT1,CHPT1,UGT8,PLA2G12B
ko03050	Proteasome	0.706699037185073	-0.347150393695945	45	39	0.00619047619047619	6300	7161	5698,5690,10197,5717,5695,5693,5692,51371,5687,7979,5686,5702,5708,5700,122706,5714,10213,9861,5684,5719,3458,5720,5707,5691,11047,5699,5706,5694,5685,5682,9491,23198,5713,5701,5710,5718,5704,143471,5696	PSMB9,PSMB2,PSME3,PSMD11,PSMB7,PSMB5,PSMB4,POMP,PSMA6,SEM1,PSMA5,PSMC3,PSMD2,PSMC1,PSMB11,PSMD8,PSMD14,PSMD6,PSMA3,PSMD13,IFNG,PSME1,PSMD1,PSMB3,ADRM1,PSMB10,PSMC6,PSMB6,PSMA4,PSMA1,PSMF1,PSME4,PSMD7,PSMC2,PSMD4,PSMD12,PSMC4,PSMA8,PSMB8
hsa01200	Carbon metabolism	0.707570692260715	-0.345917736066551	114	99	0.0157142857142857	6300	7161	113675,6472,55753,6390,26275,2027,2805,2098,80201,1738,38,29968,5232,2203,7167,2821,50,48,229,5214,221823,55902,5161,3420,54363,2023,83440,8801,6470,6392,414328,34,5313,84693,35,6389,9563,5211,4329,2731,1737,1373,4191,189,51179,5223,3101,39,6888,2806,7086,84532,2026,6120,5224,1431,5723,4190,128,2597,5162,5315,3418,25796,26007,729020,4524,5095,3030,3098,275,226,1743,2271,5096,847,283871,5226,5091,3099,4200,4967,4594,10873,84706,6391,4199,8802,8803,84076,3417,2746,132158,10993,8789,3419,1962,22934,2645	SDSL,SHMT2,OGDHL,SDHB,HIBCH,ENO3,GOT1,ESD,HKDC1,DLD,ACAT1,PSAT1,PGK2,FBP1,TPI1,GPI,ACO2,ACO1,ALDOB,PFKP,PRPS1L1,ACSS2,PDHA2,IDH3B,HAO1,ENO1,ADPGK,SUCLG2,SHMT1,SDHD,IDNK,ACADM,PKLR,MCEE,ACADS,SDHA,H6PD,PFKL,ALDH6A1,GLDC,DLAT,CPS1,MDH2,AGXT,HAO2,PGAM1,HK3,ACAT2,TALDO1,GOT2,TKT,ACSS1,ENO2,RPE,PGAM2,CS,PSPH,MDH1,ADH5,GAPDH,PDHB,PKM,IDH2,PGLS,TKFC,RPEL1,MTHFR,PCCA,HADHA,HK1,AMT,ALDOA,DLST,FH,PCCB,CAT,PGP,PGD,PC,HK2,ME2,OGDH,MMUT,ME3,GPT2,SDHC,ME1,SUCLG1,SUCLA2,TKTL2,IDH1,GLUD1,GLYCTK,SDS,FBP2,IDH3A,EHHADH,RPIA,GCK
ko01200	Carbon metabolism	0.707570692260715	-0.345917736066551	114	99	0.0157142857142857	6300	7161	5095,3030,3098,26007,25796,729020,4524,5162,5315,3418,2026,6120,5224,1431,5723,4190,128,2597,10993,8789,3419,1962,22934,2645,84706,6391,4199,8802,8803,84076,3417,2746,132158,847,283871,5226,5091,3099,4200,4967,4594,10873,275,226,1743,2271,5096,5161,3420,54363,2023,83440,7167,2821,50,229,48,5214,221823,55902,1738,38,29968,5232,2203,113675,6472,55753,6390,2027,26275,2805,2098,80201,6888,2806,7086,84532,9563,2731,4329,5211,1737,1373,4191,189,51179,3101,5223,39,34,5313,84693,35,6389,8801,6470,6392,414328	PCCA,HADHA,HK1,TKFC,PGLS,RPEL1,MTHFR,PDHB,PKM,IDH2,ENO2,RPE,PGAM2,CS,PSPH,MDH1,ADH5,GAPDH,SDS,FBP2,IDH3A,EHHADH,RPIA,GCK,GPT2,SDHC,ME1,SUCLG1,SUCLA2,TKTL2,IDH1,GLUD1,GLYCTK,CAT,PGP,PGD,PC,HK2,ME2,OGDH,MMUT,ME3,AMT,ALDOA,DLST,FH,PCCB,PDHA2,IDH3B,HAO1,ENO1,ADPGK,TPI1,GPI,ACO2,ALDOB,ACO1,PFKP,PRPS1L1,ACSS2,DLD,ACAT1,PSAT1,PGK2,FBP1,SDSL,SHMT2,OGDHL,SDHB,ENO3,HIBCH,GOT1,ESD,HKDC1,TALDO1,GOT2,TKT,ACSS1,H6PD,GLDC,ALDH6A1,PFKL,DLAT,CPS1,MDH2,AGXT,HAO2,HK3,PGAM1,ACAT2,ACADM,PKLR,MCEE,ACADS,SDHA,SUCLG2,SHMT1,SDHD,IDNK
hsa05310	Asthma	0.710574954326937	-0.341680841827029	30	26	0.00412698412698413	6300	7161	3117,2205,3567,5553,3111,3578,3108,6037,3586,3123,3122,3119,8288,3127,958,6356,3596,2207,3113,3112,3118,3565,7124,3109,3562,2206	HLA-DQA1,FCER1A,IL5,PRG2,HLA-DOA,IL9,HLA-DMA,RNASE3,IL10,HLA-DRB1,HLA-DRA,HLA-DQB1,EPX,HLA-DRB5,CD40,CCL11,IL13,FCER1G,HLA-DPA1,HLA-DOB,HLA-DQA2,IL4,TNF,HLA-DMB,IL3,MS4A2
ko05310	Asthma	0.710574954326937	-0.341680841827029	30	26	0.00412698412698413	6300	7161	2205,3117,3567,6037,5553,3111,3108,3578,3586,3123,3122,3119,8288,6356,3596,3127,958,3113,3112,3118,2207,3565,7124,3562,3109,2206	FCER1A,HLA-DQA1,IL5,RNASE3,PRG2,HLA-DOA,HLA-DMA,IL9,IL10,HLA-DRB1,HLA-DRA,HLA-DQB1,EPX,CCL11,IL13,HLA-DRB5,CD40,HLA-DPA1,HLA-DOB,HLA-DQA2,FCER1G,IL4,TNF,IL3,HLA-DMB,MS4A2
ko05320	Autoimmune thyroid disease	0.716332885013885	-0.333610296861047	52	45	0.00714285714285714	6300	7161	3119,3123,3586,3122,355,3105,3108,3111,3452,7253,7252,3443,3442,3134,3117,1493,3565,3439,3113,5551,3112,7038,3135,3441,958,3127,940,7173,3449,3558,3002,1081,3567,941,3448,3440,3445,3109,3118,356,3133,3106,3444,3107,942	HLA-DQB1,HLA-DRB1,IL10,HLA-DRA,FAS,HLA-A,HLA-DMA,HLA-DOA,IFNA21,TSHR,TSHB,IFNA6,IFNA5,HLA-F,HLA-DQA1,CTLA4,IL4,IFNA1,HLA-DPA1,PRF1,HLA-DOB,TG,HLA-G,IFNA4,CD40,HLA-DRB5,CD28,TPO,IFNA16,IL2,GZMB,CGA,IL5,CD80,IFNA14,IFNA2,IFNA8,HLA-DMB,HLA-DQA2,FASLG,HLA-E,HLA-B,IFNA7,HLA-C,CD86
hsa05320	Autoimmune thyroid disease	0.716332885013885	-0.333610296861047	52	45	0.00714285714285714	6300	7161	3112,5551,3113,3439,3565,1493,3449,7173,3127,940,958,3441,3135,7038,3452,3108,3111,3105,355,3122,3123,3586,3119,3117,3134,3442,3443,7252,7253,356,3118,3109,3107,942,3444,3106,3133,1081,3002,3558,3445,3448,3440,941,3567	HLA-DOB,PRF1,HLA-DPA1,IFNA1,IL4,CTLA4,IFNA16,TPO,HLA-DRB5,CD28,CD40,IFNA4,HLA-G,TG,IFNA21,HLA-DMA,HLA-DOA,HLA-A,FAS,HLA-DRA,HLA-DRB1,IL10,HLA-DQB1,HLA-DQA1,HLA-F,IFNA5,IFNA6,TSHB,TSHR,FASLG,HLA-DQA2,HLA-DMB,HLA-C,CD86,IFNA7,HLA-B,HLA-E,CGA,GZMB,IL2,IFNA8,IFNA14,IFNA2,CD80,IL5
M00158	F-type ATPase, eukaryotes	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	509,10632,516,498,515,513,517,506,518,10476,514,539,522	ATP5F1C,ATP5MG,ATP5MC1,ATP5F1A,ATP5PB,ATP5F1D,ATP5MC2,ATP5F1B,ATP5MC3,ATP5PD,ATP5F1E,ATP5PO,ATP5PF
hsa_M00146	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	56901,126328,51079,4706,4698,4695,55967,4696,4704,4700,4705,4702,4697	NDUFA4L2,NDUFA11,NDUFA13,NDUFAB1,NDUFA5,NDUFA2,NDUFA12,NDUFA3,NDUFA9,NDUFA6,NDUFA10,NDUFA8,NDUFA4
hsa_M00158	F-type ATPase, eukaryotes	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	539,522,514,10476,518,515,498,10632,516,509,506,513,517	ATP5PO,ATP5PF,ATP5F1E,ATP5PD,ATP5MC3,ATP5PB,ATP5F1A,ATP5MG,ATP5MC1,ATP5F1C,ATP5F1B,ATP5F1D,ATP5MC2
hsa00730	Thiamine metabolism	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	27010,203,26289,248,250,205,52,251,84284,122481,204,249,79178	TPK1,AK1,AK5,ALPI,ALPP,AK4,ACP1,ALPG,NTPCR,AK7,AK2,ALPL,THTPA
hsa_M00686	Toll-like receptor signaling	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	4615,7099,10454,1147,6885,5970,4790,4792,23118,3551,7097,51135,7189	MYD88,TLR4,TAB1,CHUK,MAP3K7,RELA,NFKB1,NFKBIA,TAB2,IKBKB,TLR2,IRAK4,TRAF6
M00686	Toll-like receptor signaling	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	23118,4792,4790,7189,51135,7097,3551,7099,4615,5970,1147,6885,10454	TAB2,NFKBIA,NFKB1,TRAF6,IRAK4,TLR2,IKBKB,TLR4,MYD88,RELA,CHUK,MAP3K7,TAB1
M00146	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	4696,4704,4697,4700,4705,4702,126328,51079,4706,56901,55967,4698,4695	NDUFA3,NDUFA9,NDUFA4,NDUFA6,NDUFA10,NDUFA8,NDUFA11,NDUFA13,NDUFAB1,NDUFA4L2,NDUFA12,NDUFA5,NDUFA2
ko00730	Thiamine metabolism	0.733664752465036	-0.30970309521619	15	13	0.00206349206349206	6300	7161	205,52,251,248,250,26289,27010,203,249,79178,122481,204,84284	AK4,ACP1,ALPG,ALPI,ALPP,AK5,TPK1,AK1,ALPL,THTPA,AK7,AK2,NTPCR
hsa04640	Hematopoietic cell lineage	0.739705791894155	-0.301502750360628	96	83	0.0131746031746032	6300	7161	290,948,917,3127,930,2209,3674,928,3559,3113,960,3112,3565,3568,911,920,3574,1378,3675,3117,929,1436,1441,1437,916,2811,3575,3108,3111,933,3570,2993,912,924,7850,945,3119,3553,3123,3122,3552,966,2056,913,926,915,952,2057,909,1791,914,3554,2815,3118,1604,3562,3109,1435,7124,3676,3690,951,3673,3672,3566,2208,3815,931,3655,3567,1380,3590,4254,3569,947,921,910,7037,2322,2814,2323,3684,4311	ANPEP,CD36,CD3G,HLA-DRB5,CD19,FCGR1A,ITGA2B,CD9,IL2RA,HLA-DPA1,CD44,HLA-DOB,IL4,IL5RA,CD1C,CD4,IL7,CR1,ITGA3,HLA-DQA1,CD14,CSF1R,CSF3R,CSF2,CD3E,GP1BA,IL7R,HLA-DMA,HLA-DOA,CD22,IL6R,GYPA,CD1D,CD7,IL1R2,CD33,HLA-DQB1,IL1B,HLA-DRB1,HLA-DRA,IL1A,CD59,EPO,CD1E,CD8B,CD3D,CD38,EPOR,CD1A,DNTT,CD2,IL1R1,GP9,HLA-DQA2,CD55,IL3,HLA-DMB,CSF1,TNF,ITGA4,ITGB3,CD37,ITGA2,ITGA1,IL4R,FCER2,KIT,MS4A1,ITGA6,IL5,CR2,IL11RA,KITLG,IL6,CD34,CD5,CD1B,TFRC,FLT3,GP5,FLT3LG,ITGAM,MME
ko04640	Hematopoietic cell lineage	0.739705791894155	-0.301502750360628	96	83	0.0131746031746032	6300	7161	3675,3117,929,1436,1441,916,1437,2811,3575,933,3108,3570,3111,2993,912,924,7850,945,3119,3123,3553,3552,3122,948,290,917,3127,2209,3674,930,928,3559,960,3113,3112,3565,3568,911,920,3574,1378,3690,3673,951,3672,3566,2208,3815,931,3655,3567,1380,3590,4254,3569,947,921,910,7037,2322,2814,2323,3684,4311,966,2056,913,926,915,952,2057,909,1791,914,3554,3118,2815,1604,3109,3562,1435,7124,3676	ITGA3,HLA-DQA1,CD14,CSF1R,CSF3R,CD3E,CSF2,GP1BA,IL7R,CD22,HLA-DMA,IL6R,HLA-DOA,GYPA,CD1D,CD7,IL1R2,CD33,HLA-DQB1,HLA-DRB1,IL1B,IL1A,HLA-DRA,CD36,ANPEP,CD3G,HLA-DRB5,FCGR1A,ITGA2B,CD19,CD9,IL2RA,CD44,HLA-DPA1,HLA-DOB,IL4,IL5RA,CD1C,CD4,IL7,CR1,ITGB3,ITGA2,CD37,ITGA1,IL4R,FCER2,KIT,MS4A1,ITGA6,IL5,CR2,IL11RA,KITLG,IL6,CD34,CD5,CD1B,TFRC,FLT3,GP5,FLT3LG,ITGAM,MME,CD59,EPO,CD1E,CD8B,CD3D,CD38,EPOR,CD1A,DNTT,CD2,IL1R1,HLA-DQA2,GP9,CD55,HLA-DMB,IL3,CSF1,TNF,ITGA4
hsa03030	DNA replication	0.739942180566008	-0.301183230206829	36	31	0.00492063492063492	6300	7161	5424,2237,57804,56655,6117,84153,6119,5983,5111,5982,79621,5985,5558,23649,4175,5427,4172,4173,10535,1763,3978,246243,5557,10714,4174,5981,6742,4171,5984,6118,54107	POLD1,FEN1,POLD4,POLE4,RPA1,RNASEH2C,RPA3,RFC3,PCNA,RFC2,RNASEH2B,RFC5,PRIM2,POLA2,MCM6,POLE2,MCM3,MCM4,RNASEH2A,DNA2,LIG1,RNASEH1,PRIM1,POLD3,MCM5,RFC1,SSBP1,MCM2,RFC4,RPA2,POLE3
ko03030	DNA replication	0.739942180566008	-0.301183230206829	36	31	0.00492063492063492	6300	7161	6118,5984,4171,54107,5981,4174,10714,6742,1763,3978,5557,246243,10535,23649,5558,4173,4172,5427,4175,6119,84153,5985,79621,5982,5111,5983,56655,6117,57804,5424,2237	RPA2,RFC4,MCM2,POLE3,RFC1,MCM5,POLD3,SSBP1,DNA2,LIG1,PRIM1,RNASEH1,RNASEH2A,POLA2,PRIM2,MCM4,MCM3,POLE2,MCM6,RPA3,RNASEH2C,RFC5,RNASEH2B,RFC2,PCNA,RFC3,POLE4,RPA1,POLD4,POLD1,FEN1
ko05340	Primary immunodeficiency	0.739942180566008	-0.301183230206829	36	31	0.00492063492063492	6300	7161	7535,6890,64421,5788,3575,916,5994,115650,3543,84876,29851,7374,6891,920,4261,23495,29760,100,3718,915,326,958,926,57379,5993,930,8625,5896,3932,973,5897	ZAP70,TAP1,DCLRE1C,PTPRC,IL7R,CD3E,RFXAP,TNFRSF13C,IGLL1,ORAI1,ICOS,UNG,TAP2,CD4,CIITA,TNFRSF13B,BLNK,ADA,JAK3,CD3D,AIRE,CD40,CD8B,AICDA,RFX5,CD19,RFXANK,RAG1,LCK,CD79A,RAG2
hsa05340	Primary immunodeficiency	0.739942180566008	-0.301183230206829	36	31	0.00492063492063492	6300	7161	5788,64421,3575,7535,6890,5994,115650,3543,916,23495,3718,100,29760,84876,29851,7374,4261,920,6891,3932,5897,973,326,915,57379,958,926,8625,930,5993,5896	PTPRC,DCLRE1C,IL7R,ZAP70,TAP1,RFXAP,TNFRSF13C,IGLL1,CD3E,TNFRSF13B,JAK3,ADA,BLNK,ORAI1,ICOS,UNG,CIITA,CD4,TAP2,LCK,RAG2,CD79A,AIRE,CD3D,AICDA,CD40,CD8B,RFXANK,CD19,RFX5,RAG1
M00065	GPI-anchor biosynthesis, core oligosaccharide	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	9487,9488,23556,284098,55650,93183,5281	PIGL,PIGB,PIGN,PIGW,PIGV,PIGM,PIGF
hsa_M00065	GPI-anchor biosynthesis, core oligosaccharide	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	5281,93183,23556,9488,55650,284098,9487	PIGF,PIGM,PIGN,PIGB,PIGV,PIGW,PIGL
hsa_M00687	MAPK (ERK1/2) signaling	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	5604,5595,5894,673,5594,5605,4342	MAP2K1,MAPK3,RAF1,BRAF,MAPK1,MAP2K2,MOS
M00010	Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	3420,3419,1431,50,3418,48,3417	IDH3B,IDH3A,CS,ACO2,IDH2,ACO1,IDH1
ko00740	Riboflavin metabolism	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	80308,5167,55312,53,5169,52,54	FLAD1,ENPP1,RFK,ACP2,ENPP3,ACP1,ACP5
hsa00740	Riboflavin metabolism	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	5169,52,55312,53,54,80308,5167	ENPP3,ACP1,RFK,ACP2,ACP5,FLAD1,ENPP1
M00687	MAPK (ERK1/2) signaling	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	5595,5604,5894,673,5594,5605,4342	MAPK3,MAP2K1,RAF1,BRAF,MAPK1,MAP2K2,MOS
hsa_M00010	Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate	0.751265394274074	-0.28599630179648	8	7	0.00111111111111111	6300	7161	48,3417,3418,3420,1431,3419,50	ACO1,IDH1,IDH2,IDH3B,CS,IDH3A,ACO2
hsa00564	Glycerophospholipid metabolism	0.752382488096932	-0.284510456551094	95	82	0.013015873015873	6300	7161	23761,55500,26279,10434,54947,9162,9489,23171,11145,391013,57678,56261,2819,79143,1040,81490,8443,162466,64600,54675,30814,1607,5337,5130,10908,23175,151056,5320,160851,1606,150763,1119,8525,1609,10390,55224,81579,129642,8527,100137049,9791,56894,10162,10400,5321,8526,64900,154141,50487,8613,8612,8398,122618,1608,8760,2820,5833,123745,23646,5338,10423,9663,11313,9926,255189,8605,8611,5319,55326,5322,79888,84647,56994,23659,283748,253558,84803,64850,56895,1103,137964,43	PISD,ETNK1,PLA2G2D,LYPLA1,LPCAT2,DGKI,PGS1,GPD1L,PLAAT3,PLA2G2C,GPAM,GPCPD1,GPD1,MBOAT7,CDS1,PTDSS2,GNPAT,PHOSPHO1,PLA2G2F,CRLS1,PLA2G2E,DGKB,PLD1,PCYT1A,PNPLA6,LPIN1,PLB1,PLA2G2A,DGKH,DGKA,GPAT2,CHKA,DGKZ,DGKQ,CEPT1,ETNK2,PLA2G12A,MBOAT2,DGKD,PLA2G4B,PTDSS1,AGPAT3,LPCAT3,PEMT,PLA2G4A,DGKE,LPIN3,MBOAT1,PLA2G3,PLPP3,PLPP2,PLA2G6,PLD4,DGKG,CDS2,GPD2,PCYT2,PLA2G4E,PLD3,PLD2,CDIPT,LPIN2,LYPLA2,LPGAT1,PLA2G4F,PLA2G4C,PLPP1,PLA2G1B,AGPAT5,PLA2G5,LPCAT1,PLA2G12B,CHPT1,PLA2G15,PLA2G4D,LCLAT1,GPAT3,ETNPPL,AGPAT4,CHAT,GPAT4,ACHE
ko00564	Glycerophospholipid metabolism	0.752382488096932	-0.284510456551094	95	82	0.013015873015873	6300	7161	9663,255189,9926,11313,8611,8605,5322,55326,5319,56994,84647,79888,253558,283748,23659,56895,64850,84803,43,1103,137964,9791,56894,129642,100137049,8527,10162,10400,50487,154141,64900,5321,8526,122618,8612,8398,8613,8760,1608,2820,5833,10423,23646,5338,123745,54675,64600,162466,1607,30814,151056,23175,10908,5337,5130,1606,160851,5320,150763,1119,8525,55224,10390,1609,81579,10434,26279,55500,23761,54947,9489,9162,391013,11145,23171,79143,2819,56261,57678,8443,81490,1040	LPIN2,PLA2G4F,LPGAT1,LYPLA2,PLPP1,PLA2G4C,PLA2G5,AGPAT5,PLA2G1B,CHPT1,PLA2G12B,LPCAT1,LCLAT1,PLA2G4D,PLA2G15,AGPAT4,ETNPPL,GPAT3,ACHE,CHAT,GPAT4,PTDSS1,AGPAT3,MBOAT2,PLA2G4B,DGKD,LPCAT3,PEMT,PLA2G3,MBOAT1,LPIN3,PLA2G4A,DGKE,PLD4,PLPP2,PLA2G6,PLPP3,CDS2,DGKG,GPD2,PCYT2,CDIPT,PLD3,PLD2,PLA2G4E,CRLS1,PLA2G2F,PHOSPHO1,DGKB,PLA2G2E,PLB1,LPIN1,PNPLA6,PLD1,PCYT1A,DGKA,DGKH,PLA2G2A,GPAT2,CHKA,DGKZ,ETNK2,CEPT1,DGKQ,PLA2G12A,LYPLA1,PLA2G2D,ETNK1,PISD,LPCAT2,PGS1,DGKI,PLA2G2C,PLAAT3,GPD1L,MBOAT7,GPD1,GPCPD1,GPAM,GNPAT,PTDSS2,CDS1
ko00330	Arginine and proline metabolism	0.769444137937149	-0.262086923611728	49	42	0.00666666666666667	6300	7161	113451,6723,65263,55748,5832,8974,2805,219,383,217,4953,29920,262,54498,4942,4846,283208,384,2628,1152,112817,1158,501,8659,5625,1610,223,4842,5831,548596,5033,2806,1159,58510,79814,1160,2593,112849,84735,51056,26,224	AZIN2,SRM,PYCR3,CNDP2,ALDH18A1,P4HA2,GOT1,ALDH1B1,ARG1,ALDH2,ODC1,PYCR2,AMD1,SMOX,OAT,NOS3,P4HA3,ARG2,GATM,CKB,HOGA1,CKM,ALDH7A1,ALDH4A1,PRODH,DAO,ALDH9A1,NOS1,PYCR1,CKMT1A,P4HA1,GOT2,CKMT1B,PRODH2,AGMAT,CKMT2,GAMT,L3HYPDH,CNDP1,LAP3,AOC1,ALDH3A2
hsa00330	Arginine and proline metabolism	0.769444137937149	-0.262086923611728	49	42	0.00666666666666667	6300	7161	5625,1610,8659,501,548596,5831,4842,223,1159,2806,5033,26,224,51056,84735,112849,2593,1160,79814,58510,113451,6723,65263,4953,383,219,217,5832,8974,2805,55748,4846,283208,4942,54498,29920,262,1158,1152,112817,2628,384	PRODH,DAO,ALDH4A1,ALDH7A1,CKMT1A,PYCR1,NOS1,ALDH9A1,CKMT1B,GOT2,P4HA1,AOC1,ALDH3A2,LAP3,CNDP1,L3HYPDH,GAMT,CKMT2,AGMAT,PRODH2,AZIN2,SRM,PYCR3,ODC1,ARG1,ALDH1B1,ALDH2,ALDH18A1,P4HA2,GOT1,CNDP2,NOS3,P4HA3,OAT,SMOX,PYCR2,AMD1,CKM,CKB,HOGA1,GATM,ARG2
hsa_M00103	Cholecalciferol biosynthesis	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	120227,1594	CYP2R1,CYP27B1
ko00300	Lysine biosynthesis	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	501,51166	ALDH7A1,AADAT
hsa_M00554	Nucleotide sugar biosynthesis, galactose => UDP-galactose	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	2592,2584	GALT,GALK1
M00067	Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	7368,9514	UGT8,GAL3ST1
M00083	Fatty acid biosynthesis, elongation	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	2194,54995	FASN,OXSM
hsa00300	Lysine biosynthesis	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	51166,501	AADAT,ALDH7A1
hsa_M00067	Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	7368,9514	UGT8,GAL3ST1
M00399	Cap binding complex	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	4686,22916	NCBP1,NCBP2
M00554	Nucleotide sugar biosynthesis, galactose => UDP-galactose	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	2592,2584	GALT,GALK1
M00293	DNA polymerase zeta  complex	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	10459,5980	MAD2L2,REV3L
M00066	Lactosylceramide biosynthesis	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	7357,9331	UGCG,B4GALT6
hsa_M00338	Cysteine biosynthesis, homocysteine + serine => cysteine	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	875,1491	CBS,CTH
hsa_M00066	Lactosylceramide biosynthesis	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	9331,7357	B4GALT6,UGCG
M00068	Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	8706,53947	B3GALNT1,A4GALT
M00103	Cholecalciferol biosynthesis	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	120227,1594	CYP2R1,CYP27B1
hsa_M00399	Cap binding complex	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	22916,4686	NCBP2,NCBP1
hsa_M00068	Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	53947,8706	A4GALT,B3GALNT1
hsa_M00294	DNA polymerase gamma complex	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	11232,5428	POLG2,POLG
hsa_M00083	Fatty acid biosynthesis, elongation	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	54995,2194	OXSM,FASN
M00294	DNA polymerase gamma complex	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	5428,11232	POLG,POLG2
M00338	Cysteine biosynthesis, homocysteine + serine => cysteine	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	1491,875	CTH,CBS
hsa_M00293	DNA polymerase zeta  complex	0.77397237831538	-0.256219092960237	2	2	0.000317460317460317	6300	7161	10459,5980	MAD2L2,REV3L
ko04130	SNARE interactions in vesicular transport	0.781492853785237	-0.246549273391158	34	29	0.0046031746031746	6300	7161	9527,10228,9570,8675,8673,55014,10282,10652,6810,6843,51272,6809,2054,10791,55850,9554,8773,8674,662,53407,112755,10490,6811,6844,8676,8417,9482,9341,8677	GOSR1,STX6,GOSR2,STX16,VAMP8,STX17,BET1,YKT6,STX4,VAMP1,BET1L,STX3,STX2,VAMP5,USE1,SEC22B,SNAP23,VAMP4,BNIP1,STX18,STX1B,VTI1B,STX5,VAMP2,STX11,STX7,STX8,VAMP3,STX10
hsa04130	SNARE interactions in vesicular transport	0.781492853785237	-0.246549273391158	34	29	0.0046031746031746	6300	7161	8417,9482,9341,8677,10490,6811,6844,8676,662,53407,112755,2054,10791,55850,9554,8773,8674,6843,51272,6809,10652,6810,8675,8673,55014,10282,9527,10228,9570	STX7,STX8,VAMP3,STX10,VTI1B,STX5,VAMP2,STX11,BNIP1,STX18,STX1B,STX2,VAMP5,USE1,SEC22B,SNAP23,VAMP4,VAMP1,BET1L,STX3,YKT6,STX4,STX16,VAMP8,STX17,BET1,GOSR1,STX6,GOSR2
hsa00100	Steroid biosynthesis	0.786541364766201	-0.240109964394192	20	17	0.0026984126984127	6300	7161	6307,1595,1718,1056,6713,3988,1591,7108,120227,1594,1717,8435,51478,6646,10826,2222,6309	MSMO1,CYP51A1,DHCR24,CEL,SQLE,LIPA,CYP24A1,TM7SF2,CYP2R1,CYP27B1,DHCR7,SOAT2,HSD17B7,SOAT1,FAXDC2,FDFT1,SC5D
ko00100	Steroid biosynthesis	0.786541364766201	-0.240109964394192	20	17	0.0026984126984127	6300	7161	51478,8435,1717,6309,2222,10826,6646,3988,1591,1718,1056,6713,1595,6307,7108,1594,120227	HSD17B7,SOAT2,DHCR7,SC5D,FDFT1,FAXDC2,SOAT1,LIPA,CYP24A1,DHCR24,CEL,SQLE,CYP51A1,MSMO1,TM7SF2,CYP27B1,CYP2R1
hsa_M00086	beta-Oxidation, acyl-CoA synthesis	0.798202675307665	-0.225392734697269	7	6	0.000952380952380952	6300	7161	51703,81616,2181,23205,2180,23305	ACSL5,ACSBG2,ACSL3,ACSBG1,ACSL1,ACSL6
M00120	Coenzyme A biosynthesis, pantothenate => CoA	0.798202675307665	-0.225392734697269	7	6	0.000952380952380952	6300	7161	60490,79646,55229,79717,80025,53354	PPCDC,PANK3,PANK4,PPCS,PANK2,PANK1
M00007	Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P	0.798202675307665	-0.225392734697269	7	6	0.000952380952380952	6300	7161	6888,6120,7086,84076,22934,729020	TALDO1,RPE,TKT,TKTL2,RPIA,RPEL1
M00086	beta-Oxidation, acyl-CoA synthesis	0.798202675307665	-0.225392734697269	7	6	0.000952380952380952	6300	7161	81616,51703,23205,2180,23305,2181	ACSBG2,ACSL5,ACSBG1,ACSL1,ACSL6,ACSL3
hsa_M00120	Coenzyme A biosynthesis, pantothenate => CoA	0.798202675307665	-0.225392734697269	7	6	0.000952380952380952	6300	7161	53354,60490,79646,79717,80025,55229	PANK1,PPCDC,PANK3,PPCS,PANK2,PANK4
hsa_M00007	Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P	0.798202675307665	-0.225392734697269	7	6	0.000952380952380952	6300	7161	6120,6888,84076,7086,22934,729020	RPE,TALDO1,TKTL2,TKT,RPIA,RPEL1
M00403	HRD1/SEL1 ERAD complex	0.800838953495489	-0.222095408938035	13	11	0.00174603174603175	6300	7161	9709,10956,79139,7353,7415,55829,55666,91319,84447,80343,6400	HERPUD1,OS9,DERL1,UFD1,VCP,SELENOS,NPLOC4,DERL3,SYVN1,SEL1L2,SEL1L
hsa_M00403	HRD1/SEL1 ERAD complex	0.800838953495489	-0.222095408938035	13	11	0.00174603174603175	6300	7161	55829,55666,91319,80343,9709,10956,7353,6400,84447,7415,79139	SELENOS,NPLOC4,DERL3,SEL1L2,HERPUD1,OS9,UFD1,SEL1L,SYVN1,VCP,DERL1
ko05033	Nicotine addiction	0.801215933413767	-0.221624788451413	40	34	0.0053968253968254	6300	7161	2565,2568,2560,2562,116444,2891,2563,57030,2559,2554,57084,2904,140679,2557,2906,2893,2903,2561,116443,2558,2890,773,2555,2905,246213,2569,1139,200959,2570,8973,2567,1137,1141,2566	GABRG1,GABRP,GABRB1,GABRB3,GRIN3B,GRIA2,GABRD,SLC17A7,GABRA6,GABRA1,SLC17A6,GRIN2B,SLC32A1,GABRA4,GRIN2D,GRIA4,GRIN2A,GABRB2,GRIN3A,GABRA5,GRIA1,CACNA1A,GABRA2,GRIN2C,SLC17A8,GABRR1,CHRNA7,GABRR3,GABRR2,CHRNA6,GABRG3,CHRNA4,CHRNB2,GABRG2
hsa05033	Nicotine addiction	0.801215933413767	-0.221624788451413	40	34	0.0053968253968254	6300	7161	57030,2559,140679,2554,2904,57084,2562,116444,2891,2563,2565,2560,2568,2906,2557,246213,200959,2570,1139,2569,2890,2558,2555,773,2905,2893,2561,2903,116443,2566,2567,1137,8973,1141	SLC17A7,GABRA6,SLC32A1,GABRA1,GRIN2B,SLC17A6,GABRB3,GRIN3B,GRIA2,GABRD,GABRG1,GABRB1,GABRP,GRIN2D,GABRA4,SLC17A8,GABRR3,GABRR2,CHRNA7,GABRR1,GRIA1,GABRA5,GABRA2,CACNA1A,GRIN2C,GRIA4,GABRB2,GRIN2A,GRIN3A,GABRG2,GABRG3,CHRNA4,CHRNA6,CHRNB2
ko00531	Glycosaminoglycan degradation	0.812635055953106	-0.207473155880194	19	16	0.00253968253968254	6300	7161	8692,60495,3373,10855,2799,138050,6677,2588,2990,6448,3425,2720,3074,23553,8372,411	HYAL2,HPSE2,HYAL1,HPSE,GNS,HGSNAT,SPAM1,GALNS,GUSB,SGSH,IDUA,GLB1,HEXB,HYAL4,HYAL3,ARSB
hsa00531	Glycosaminoglycan degradation	0.812635055953106	-0.207473155880194	19	16	0.00253968253968254	6300	7161	3074,2720,3425,6448,411,8372,23553,3373,60495,8692,2990,2588,6677,138050,10855,2799	HEXB,GLB1,IDUA,SGSH,ARSB,HYAL3,HYAL4,HYAL1,HPSE2,HYAL2,GUSB,GALNS,SPAM1,HGSNAT,HPSE,GNS
ko00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.825908275390164	-0.191271558370448	25	21	0.00333333333333333	6300	7161	2822,23556,54872,284098,84720,8818,9487,51604,5283,5281,51227,9488,5279,80235,55650,54965,10026,9091,128869,80055,93183	GPLD1,PIGN,PIGG,PIGW,PIGO,DPM2,PIGL,PIGT,PIGH,PIGF,PIGP,PIGB,PIGC,PIGZ,PIGV,PIGX,PIGK,PIGQ,PIGU,PGAP1,PIGM
hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.825908275390164	-0.191271558370448	25	21	0.00333333333333333	6300	7161	9488,51227,80235,55650,5279,54965,10026,80055,128869,9091,93183,54872,2822,23556,284098,84720,8818,9487,5283,51604,5281	PIGB,PIGP,PIGZ,PIGV,PIGC,PIGX,PIGK,PGAP1,PIGU,PIGQ,PIGM,PIGG,GPLD1,PIGN,PIGW,PIGO,DPM2,PIGL,PIGH,PIGT,PIGF
M00001	Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	0.825908275390164	-0.191271558370448	25	21	0.00333333333333333	6300	7161	5232,2023,2645,3098,83440,5313,3099,5315,2027,229,5214,3101,5223,2597,80201,2026,7167,5211,2821,5224,226	PGK2,ENO1,GCK,HK1,ADPGK,PKLR,HK2,PKM,ENO3,ALDOB,PFKP,HK3,PGAM1,GAPDH,HKDC1,ENO2,TPI1,PFKL,GPI,PGAM2,ALDOA
hsa_M00001	Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	0.825908275390164	-0.191271558370448	25	21	0.00333333333333333	6300	7161	2821,5224,226,2026,7167,5211,5223,3101,80201,2597,5214,229,2027,3099,5315,5313,2645,83440,3098,5232,2023	GPI,PGAM2,ALDOA,ENO2,TPI1,PFKL,PGAM1,HK3,HKDC1,GAPDH,PFKP,ALDOB,ENO3,HK2,PKM,PKLR,GCK,ADPGK,HK1,PGK2,ENO1
hsa04260	Cardiac muscle contraction	0.827115000194799	-0.189811536558512	74	63	0.01	6300	7161	4633,70,9167,786,476,481,93589,27092,6262,4624,7169,170712,1347,477,7386,59283,482,10975,341947,1351,27091,1346,1339,4625,55799,1337,7134,7171,6548,10369,29796,440567,776,486,7381,781,59285,1327,4635,6546,1350,9254,1340,1345,478,483,779,9377,775,7385,7170,1329,783,10368,488,785,480,4634,784,7384,7139,7168,59284	MYL2,ACTC1,COX7A2L,CACNG1,ATP1A1,ATP1B1,CACNA2D4,CACNG4,RYR2,MYH6,TPM2,COX7B2,COX7A2,ATP1A2,UQCRFS1,CACNG8,ATP1B2,UQCR11,COX8C,COX8A,CACNG5,COX7A1,COX6A2,MYH7,CACNA2D3,COX6A1,TNNC1,TPM4,SLC9A1,CACNG2,UQCR10,UQCRHL,CACNA1D,FXYD2,UQCRB,CACNA2D1,CACNG6,COX4I1,MYL4,SLC8A1,COX7C,CACNA2D2,COX6B1,COX6C,ATP1A3,ATP1B3,CACNA1S,COX5A,CACNA1C,UQCRC2,TPM3,COX5B,CACNB2,CACNG3,ATP2A2,CACNB4,ATP1A4,MYL3,CACNB3,UQCRC1,TNNT2,TPM1,CACNG7
ko04260	Cardiac muscle contraction	0.827115000194799	-0.189811536558512	74	63	0.01	6300	7161	481,786,476,9167,70,4633,6262,7169,4624,27092,93589,1346,1339,27091,1351,341947,10975,59283,7386,1347,477,482,170712,781,7381,486,776,6548,7171,440567,29796,10369,4625,55799,7134,1337,1350,6546,1327,59285,4635,7170,1329,775,7385,779,483,478,9377,9254,1345,1340,4634,785,480,10368,488,783,59284,7139,7384,7168,784	ATP1B1,CACNG1,ATP1A1,COX7A2L,ACTC1,MYL2,RYR2,TPM2,MYH6,CACNG4,CACNA2D4,COX7A1,COX6A2,CACNG5,COX8A,COX8C,UQCR11,CACNG8,UQCRFS1,COX7A2,ATP1A2,ATP1B2,COX7B2,CACNA2D1,UQCRB,FXYD2,CACNA1D,SLC9A1,TPM4,UQCRHL,UQCR10,CACNG2,MYH7,CACNA2D3,TNNC1,COX6A1,COX7C,SLC8A1,COX4I1,CACNG6,MYL4,TPM3,COX5B,CACNA1C,UQCRC2,CACNA1S,ATP1B3,ATP1A3,COX5A,CACNA2D2,COX6C,COX6B1,MYL3,CACNB4,ATP1A4,CACNG3,ATP2A2,CACNB2,CACNG7,TNNT2,UQCRC1,TPM1,CACNB3
hsa_M00002	Glycolysis, core module involving three-carbon compounds	0.832711444675661	-0.183068101778536	12	10	0.00158730158730159	6300	7161	2027,5232,2023,5223,2597,7167,2026,5224,5313,5315	ENO3,PGK2,ENO1,PGAM1,GAPDH,TPI1,ENO2,PGAM2,PKLR,PKM
M00002	Glycolysis, core module involving three-carbon compounds	0.832711444675661	-0.183068101778536	12	10	0.00158730158730159	6300	7161	5232,2023,5223,2597,2027,5313,5315,7167,2026,5224	PGK2,ENO1,PGAM1,GAPDH,ENO3,PKLR,PKM,TPI1,ENO2,PGAM2
M00004	Pentose phosphate pathway (Pentose phosphate cycle)	0.832711444675661	-0.183068101778536	12	10	0.00158730158730159	6300	7161	22934,729020,84076,25796,7086,6120,2821,5226,6888,9563	RPIA,RPEL1,TKTL2,PGLS,TKT,RPE,GPI,PGD,TALDO1,H6PD
M00290	Holo-TFIIH complex	0.832711444675661	-0.183068101778536	12	10	0.00158730158730159	6300	7161	2965,2968,902,404672,2068,2967,2071,728340,1022,4331	GTF2H1,GTF2H4,CCNH,GTF2H5,ERCC2,GTF2H3,ERCC3,GTF2H2C,CDK7,MNAT1
hsa_M00004	Pentose phosphate pathway (Pentose phosphate cycle)	0.832711444675661	-0.183068101778536	12	10	0.00158730158730159	6300	7161	22934,729020,25796,7086,84076,9563,6888,5226,2821,6120	RPIA,RPEL1,PGLS,TKT,TKTL2,H6PD,TALDO1,PGD,GPI,RPE
hsa_M00290	Holo-TFIIH complex	0.832711444675661	-0.183068101778536	12	10	0.00158730158730159	6300	7161	2965,2968,404672,2967,2068,902,2071,1022,728340,4331	GTF2H1,GTF2H4,GTF2H5,GTF2H3,ERCC2,CCNH,ERCC3,CDK7,GTF2H2C,MNAT1
ko03022	Basal transcription factors	0.833755409019235	-0.181815194194055	45	38	0.00603174603174603	6300	7161	2068,2965,2960,2968,2962,2963,6874,27097,2959,2071,1022,728340,6879,6877,2957,6882,6883,6880,8148,129685,9519,2961,902,2958,6873,387332,6875,10629,2969,83860,9569,404672,6881,11036,2967,6884,138474,4331	ERCC2,GTF2H1,GTF2E1,GTF2H4,GTF2F1,GTF2F2,TAF4,TAF5L,GTF2B,ERCC3,CDK7,GTF2H2C,TAF7,TAF5,GTF2A1,TAF11,TAF12,TAF9,TAF15,TAF8,TBPL1,GTF2E2,CCNH,GTF2A2,TAF2,TBPL2,TAF4B,TAF6L,GTF2I,TAF3,GTF2IRD1,GTF2H5,TAF10,GTF2A1L,GTF2H3,TAF13,TAF1L,MNAT1
hsa03022	Basal transcription factors	0.833755409019235	-0.181815194194055	45	38	0.00603174603174603	6300	7161	2963,2962,2968,2960,2965,2068,6879,1022,728340,2071,2959,27097,6874,6880,6883,2957,6882,6877,9519,129685,8148,387332,6875,6873,2958,902,2961,9569,83860,2969,10629,2967,404672,6881,11036,4331,138474,6884	GTF2F2,GTF2F1,GTF2H4,GTF2E1,GTF2H1,ERCC2,TAF7,CDK7,GTF2H2C,ERCC3,GTF2B,TAF5L,TAF4,TAF9,TAF12,GTF2A1,TAF11,TAF5,TBPL1,TAF8,TAF15,TBPL2,TAF4B,TAF2,GTF2A2,CCNH,GTF2E2,GTF2IRD1,TAF3,GTF2I,TAF6L,GTF2H3,GTF2H5,TAF10,GTF2A1L,MNAT1,TAF1L,TAF13
hsa03040	Spliceosome	0.837200761344149	-0.177691379017312	132	113	0.0179365079365079	6300	7161	55660,10285,7307,22938,6430,6629,55119,1659,6429,6627,10992,58517,9410,25804,10465,9343,1665,9129,26121,51362,10594,4670,55110,8449,153527,10713,5356,25766,55696,11325,11017,51503,10946,6432,9128,10772,6633,27258,23020,10450,4809,6637,6628,22827,51639,51690,8896,9984,151903,9092,494115,6428,5093,9775,57461,6426,84950,3306,22985,10915,3310,84844,51645,6635,100534599,9716,57819,6626,10286,10569,4116,23350,25949,9879,6434,4686,24148,23658,23451,10189,8559,3190,8683,11157,6100,144983,51729,84321,3183,3312,56259,10291,3304,27288,10523,29896,6625,84991,220988,6636,9416,6431,10907,51691,83443,6631,3305,988,10262,22916,11338,3178,3192	PRPF40A,SMNDC1,U2AF1,SNW1,SRSF5,SNRPB2,PRPF38B,DHX8,SRSF4,SNRPA1,SF3B2,RBM25,SNRNP40,LSM4,PPIH,EFTUD2,DHX15,PRPF3,PRPF31,CDC40,PRPF8,HNRNPM,MAGOHB,DHX16,ZMAT2,USP39,PLRG1,PRPF40B,RBM22,DDX42,SNRNP27,CWC15,SF3A3,SRSF7,PRPF4,SRSF10,SNRPD2,LSM3,SNRNP200,PPIE,SNU13,SNRPG,SNRPB,PUF60,SF3B6,LSM7,BUD31,THOC1,CCDC12,SART1,RBMXL1,SRSF3,PCBP1,EIF4A3,ISY1,SRSF1,PRPF38A,HSPA2,ACIN1,TCERG1,HSPA6,PHF5A,PPIL1,SNRPE,ISY1-RAB43,AQR,LSM2,SNRPA,BCAS2,SLU7,MAGOH,U2SURP,SYF2,DDX46,TRA2B,NCBP1,PRPF6,LSM5,SF3B1,ALYREF,PRPF18,HNRNPK,SRSF9,LSM6,RP9,HNRNPA1L2,WBP11,THOC3,HNRNPC,HSPA8,CTNNBL1,SF3A1,HSPA1B,RBMXL2,CHERP,TRA2A,SNRNP70,RBM17,HNRNPA3,SNRPF,DDX23,SRSF6,TXNL4A,LSM8,SF3B5,SNRPC,HSPA1L,CDC5L,SF3B4,NCBP2,U2AF2,HNRNPA1,HNRNPU
ko03040	Spliceosome	0.837200761344149	-0.177691379017312	132	113	0.0179365079365079	6300	7161	11157,8683,3190,8559,10189,23658,23451,24148,4686,9879,6434,25949,4116,23350,10569,6626,10286,100534599,9716,57819,6635,51645,10915,3310,84844,22985,84950,3306,57461,6426,3192,3178,11338,988,10262,22916,3305,6631,6431,10907,51691,83443,9416,6636,220988,84991,6625,29896,10523,27288,3304,10291,3312,56259,3183,84321,51729,144983,6100,11017,51503,11325,5356,25766,55696,10713,8449,153527,55110,4670,10594,51362,26121,9129,1665,25804,10465,9343,58517,9410,6627,10992,1659,6429,55119,6629,22938,7307,6430,10285,55660,9775,5093,6428,9092,494115,151903,8896,9984,51690,22827,51639,6628,6637,4809,10450,23020,27258,6633,9128,10772,6432,10946	LSM6,SRSF9,HNRNPK,PRPF18,ALYREF,LSM5,SF3B1,PRPF6,NCBP1,DDX46,TRA2B,SYF2,MAGOH,U2SURP,SLU7,SNRPA,BCAS2,ISY1-RAB43,AQR,LSM2,SNRPE,PPIL1,TCERG1,HSPA6,PHF5A,ACIN1,PRPF38A,HSPA2,ISY1,SRSF1,HNRNPU,HNRNPA1,U2AF2,CDC5L,SF3B4,NCBP2,HSPA1L,SNRPC,SRSF6,TXNL4A,LSM8,SF3B5,DDX23,SNRPF,HNRNPA3,RBM17,SNRNP70,TRA2A,CHERP,RBMXL2,HSPA1B,SF3A1,HSPA8,CTNNBL1,HNRNPC,THOC3,WBP11,HNRNPA1L2,RP9,SNRNP27,CWC15,DDX42,PLRG1,PRPF40B,RBM22,USP39,DHX16,ZMAT2,MAGOHB,HNRNPM,PRPF8,CDC40,PRPF31,PRPF3,DHX15,LSM4,PPIH,EFTUD2,RBM25,SNRNP40,SNRPA1,SF3B2,DHX8,SRSF4,PRPF38B,SNRPB2,SNW1,U2AF1,SRSF5,SMNDC1,PRPF40A,EIF4A3,PCBP1,SRSF3,SART1,RBMXL1,CCDC12,BUD31,THOC1,LSM7,PUF60,SF3B6,SNRPB,SNRPG,SNU13,PPIE,SNRNP200,LSM3,SNRPD2,PRPF4,SRSF10,SRSF7,SF3A3
ko00511	Other glycan degradation	0.83760493645021	-0.177208725877979	18	15	0.00238095238095238	6300	7161	2519,23324,10825,4758,4126,284004,57704,4125,64772,4123,2629,3074,2720,175,2517	FUCA2,MAN2B2,NEU3,NEU1,MANBA,HEXD,GBA2,MAN2B1,ENGASE,MAN2C1,GBA1,HEXB,GLB1,AGA,FUCA1
ko01210	2-Oxocarboxylic acid metabolism	0.83760493645021	-0.177208725877979	18	15	0.00238095238095238	6300	7161	3418,162417,95,3419,2806,3420,48,586,3417,2805,1431,51166,50,587,84706	IDH2,NAGS,ACY1,IDH3A,GOT2,IDH3B,ACO1,BCAT1,IDH1,GOT1,CS,AADAT,ACO2,BCAT2,GPT2
hsa01210	2-Oxocarboxylic acid metabolism	0.83760493645021	-0.177208725877979	18	15	0.00238095238095238	6300	7161	587,84706,1431,51166,50,48,586,3417,2805,3419,2806,3420,162417,3418,95	BCAT2,GPT2,CS,AADAT,ACO2,ACO1,BCAT1,IDH1,GOT1,IDH3A,GOT2,IDH3B,NAGS,IDH2,ACY1
hsa00511	Other glycan degradation	0.83760493645021	-0.177208725877979	18	15	0.00238095238095238	6300	7161	10825,23324,2519,57704,284004,4126,4758,4123,4125,64772,2517,175,2720,3074,2629	NEU3,MAN2B2,FUCA2,GBA2,HEXD,MANBA,NEU1,MAN2C1,MAN2B1,ENGASE,FUCA1,AGA,GLB1,HEXB,GBA1
hsa_M00029	Urea cycle	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	1373,383,435,384,445	CPS1,ARG1,ASL,ARG2,ASS1
M00073	N-glycan precursor trimming	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	4121,23193,57134,10905,7841	MAN1A1,GANAB,MAN1C1,MAN1A2,MOGS
M00013	Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	1962,3030,26275,34,4329	EHHADH,HADHA,HIBCH,ACADM,ALDH6A1
M00029	Urea cycle	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	435,383,1373,445,384	ASL,ARG1,CPS1,ASS1,ARG2
M00424	Shelterin complex	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	26277,7014,25913,7013,65057	TINF2,TERF2,POT1,TERF1,ACD
hsa_M00085	Fatty acid biosynthesis, elongation, mitochondria	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	3030,3032,10449,3033,51102	HADHA,HADHB,ACAA2,HADH,MECR
M00085	Fatty acid biosynthesis, elongation, mitochondria	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	3030,3033,10449,3032,51102	HADHA,HADH,ACAA2,HADHB,MECR
M00285	MCM complex	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	4173,4172,4175,4174,4171	MCM4,MCM3,MCM6,MCM5,MCM2
hsa_M00013	Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	3030,1962,4329,34,26275	HADHA,EHHADH,ALDH6A1,ACADM,HIBCH
hsa_M00285	MCM complex	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	4175,4173,4172,4171,4174	MCM6,MCM4,MCM3,MCM2,MCM5
hsa_M00424	Shelterin complex	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	25913,65057,7013,26277,7014	POT1,ACD,TERF1,TINF2,TERF2
hsa_M00073	N-glycan precursor trimming	0.843924582756015	-0.1696921453029	6	5	0.000793650793650794	6300	7161	23193,4121,10905,7841,57134	GANAB,MAN1A1,MAN1A2,MOGS,MAN1C1
hsa00340	Histidine metabolism	0.846510089730824	-0.166633158128742	24	20	0.00317460317460317	6300	7161	3034,144193,221,443,220,222,84735,218,26,131669,224,501,3067,1644,55748,223,3176,138199,219,217	HAL,AMDHD1,ALDH3B1,ASPA,ALDH1A3,ALDH3B2,CNDP1,ALDH3A1,AOC1,UROC1,ALDH3A2,ALDH7A1,HDC,DDC,CNDP2,ALDH9A1,HNMT,CARNMT1,ALDH1B1,ALDH2
M00160	V-type ATPase, eukaryotes	0.846510089730824	-0.166633158128742	24	20	0.00317460317460317	6300	7161	9550,528,533,8992,50617,127124,9114,51606,90423,245972,535,529,523,10312,23545,51382,245973,155066,526,525	ATP6V1G1,ATP6V1C1,ATP6V0B,ATP6V0E1,ATP6V0A4,ATP6V1G3,ATP6V0D1,ATP6V1H,ATP6V1E2,ATP6V0D2,ATP6V0A1,ATP6V1E1,ATP6V1A,TCIRG1,ATP6V0A2,ATP6V1D,ATP6V1C2,ATP6V0E2,ATP6V1B2,ATP6V1B1
ko00340	Histidine metabolism	0.846510089730824	-0.166633158128742	24	20	0.00317460317460317	6300	7161	219,217,55748,223,138199,3176,1644,501,3067,84735,218,26,131669,224,222,443,220,3034,144193,221	ALDH1B1,ALDH2,CNDP2,ALDH9A1,CARNMT1,HNMT,DDC,ALDH7A1,HDC,CNDP1,ALDH3A1,AOC1,UROC1,ALDH3A2,ALDH3B2,ASPA,ALDH1A3,HAL,AMDHD1,ALDH3B1
hsa_M00160	V-type ATPase, eukaryotes	0.846510089730824	-0.166633158128742	24	20	0.00317460317460317	6300	7161	525,526,155066,245973,51382,23545,10312,523,529,535,90423,245972,51606,9114,127124,50617,533,8992,528,9550	ATP6V1B1,ATP6V1B2,ATP6V0E2,ATP6V1C2,ATP6V1D,ATP6V0A2,TCIRG1,ATP6V1A,ATP6V1E1,ATP6V0A1,ATP6V1E2,ATP6V0D2,ATP6V1H,ATP6V0D1,ATP6V1G3,ATP6V0A4,ATP6V0B,ATP6V0E1,ATP6V1C1,ATP6V1G1
hsa_M00355	Spliceosome, 35S U5-snRNP	0.851080346404817	-0.161248740758777	37	31	0.00492063492063492	6300	7161	6636,10594,8896,25949,6637,51362,6628,60625,51503,151903,5356,988,55696,3305,22938,3306,55094,57461,10286,3304,9716,100534599,10450,23020,9343,3312,51645,3310,6635,9410,6633	SNRPF,PRPF8,BUD31,SYF2,SNRPG,CDC40,SNRPB,DHX35,CWC15,CCDC12,PLRG1,CDC5L,RBM22,HSPA1L,SNW1,HSPA2,GPATCH1,ISY1,BCAS2,HSPA1B,AQR,ISY1-RAB43,PPIE,SNRNP200,EFTUD2,HSPA8,PPIL1,HSPA6,SNRPE,SNRNP40,SNRPD2
M00355	Spliceosome, 35S U5-snRNP	0.851080346404817	-0.161248740758777	37	31	0.00492063492063492	6300	7161	60625,51503,151903,3305,988,5356,55696,6636,10594,8896,6637,25949,6628,51362,9716,100534599,3304,10286,9343,23020,10450,3310,3312,51645,6633,6635,9410,22938,3306,55094,57461	DHX35,CWC15,CCDC12,HSPA1L,CDC5L,PLRG1,RBM22,SNRPF,PRPF8,BUD31,SNRPG,SYF2,SNRPB,CDC40,AQR,ISY1-RAB43,HSPA1B,BCAS2,EFTUD2,SNRNP200,PPIE,HSPA6,HSPA8,PPIL1,SNRPD2,SNRPE,SNRNP40,SNW1,HSPA2,GPATCH1,ISY1
hsa_M00181	RNA polymerase III, eukaryotes	0.86125005474873	-0.149370393085353	17	14	0.00222222222222222	6300	7161	661,51082,11128,171568,9533,55703,5434,55718,5440,5441,10622,51728,10623,84265	POLR3D,POLR1D,POLR3A,POLR3H,POLR1C,POLR3B,POLR2E,POLR3E,POLR2K,POLR2L,POLR3G,POLR3K,POLR3C,POLR3GL
M00089	Triacylglycerol biosynthesis	0.86125005474873	-0.149370393085353	17	14	0.00222222222222222	6300	7161	8612,8613,8611,154141,56894,129642,137964,56895,84803,253558,57678,150763,346606,84649	PLPP2,PLPP3,PLPP1,MBOAT1,AGPAT3,MBOAT2,GPAT4,AGPAT4,GPAT3,LCLAT1,GPAM,GPAT2,MOGAT3,DGAT2
M00181	RNA polymerase III, eukaryotes	0.86125005474873	-0.149370393085353	17	14	0.00222222222222222	6300	7161	55718,55703,5434,11128,171568,9533,51082,661,10623,84265,10622,5441,51728,5440	POLR3E,POLR3B,POLR2E,POLR3A,POLR3H,POLR1C,POLR1D,POLR3D,POLR3C,POLR3GL,POLR3G,POLR2L,POLR3K,POLR2K
hsa_M00089	Triacylglycerol biosynthesis	0.86125005474873	-0.149370393085353	17	14	0.00222222222222222	6300	7161	57678,253558,129642,84649,150763,56894,346606,8612,137964,8613,84803,8611,56895,154141	GPAM,LCLAT1,MBOAT2,DGAT2,GPAT2,AGPAT3,MOGAT3,PLPP2,GPAT4,PLPP3,GPAT3,PLPP1,AGPAT4,MBOAT1
hsa04614	Renin-angiotensin system	0.866018016938903	-0.143849565856784	23	19	0.00301587301587302	6300	7161	1215,5550,183,3817,4311,5547,185,1359,116512,3816,1636,4012,2028,290,4142,5972,57486,7064,1511	CMA1,PREP,AGT,KLK2,MME,PRCP,AGTR1,CPA3,MRGPRD,KLK1,ACE,LNPEP,ENPEP,ANPEP,MAS1,REN,NLN,THOP1,CTSG
ko04614	Renin-angiotensin system	0.866018016938903	-0.143849565856784	23	19	0.00301587301587302	6300	7161	290,4012,2028,4142,5972,57486,7064,1511,1215,5550,183,3817,4311,5547,185,1359,116512,3816,1636	ANPEP,LNPEP,ENPEP,MAS1,REN,NLN,THOP1,CTSG,CMA1,PREP,AGT,KLK2,MME,PRCP,AGTR1,CPA3,MRGPRD,KLK1,ACE
hsa00190	Oxidative phosphorylation	0.87376770021561	-0.134940727881809	120	102	0.0161904761904762	6300	7161	4717,8992,9167,51606,4705,23545,4719,4726,170712,539,533,1347,7386,56901,535,51079,5464,1351,245973,506,4712,10312,440567,516,29796,7381,4704,4696,127124,6391,4695,496,514,4731,1355,90423,155066,1340,9377,7385,526,4725,9550,4706,4724,51382,4718,4710,7384,10632,528,4716,1353,1352,4700,4708,4711,517,64077,498,4722,4723,10476,6390,495,374291,341947,10975,1346,1339,1337,529,4697,4729,523,525,4698,1327,522,27068,1350,245972,1345,4702,513,4714,509,1329,515,4720,4728,9114,50617,518,4707,479,6392,55967,126328,4715,4709,6389	NDUFC1,ATP6V0E1,COX7A2L,ATP6V1H,NDUFA10,ATP6V0A2,NDUFS1,NDUFS6,COX7B2,ATP5PO,ATP6V0B,COX7A2,UQCRFS1,NDUFA4L2,ATP6V0A1,NDUFA13,PPA1,COX8A,ATP6V1C2,ATP5F1B,NDUFB6,TCIRG1,UQCRHL,ATP5MC1,UQCR10,UQCRB,NDUFA9,NDUFA3,ATP6V1G3,SDHC,NDUFA2,ATP4B,ATP5F1E,NDUFV3,COX15,ATP6V1E2,ATP6V0E2,COX6B1,COX5A,UQCRC2,ATP6V1B2,NDUFS5,ATP6V1G1,NDUFAB1,NDUFS4,ATP6V1D,NDUFC2,NDUFB4,UQCRC1,ATP5MG,ATP6V1C1,NDUFB10,COX11,COX10,NDUFA6,NDUFB2,NDUFB5,ATP5MC2,LHPP,ATP5F1A,NDUFS3,NDUFV1,ATP5PD,SDHB,ATP4A,NDUFS7,COX8C,UQCR11,COX7A1,COX6A2,COX6A1,ATP6V1E1,NDUFA4,NDUFV2,ATP6V1A,ATP6V1B1,NDUFA5,COX4I1,ATP5PF,PPA2,COX7C,ATP6V0D2,COX6C,NDUFA8,ATP5F1D,NDUFB8,ATP5F1C,COX5B,ATP5PB,NDUFS2,NDUFS8,ATP6V0D1,ATP6V0A4,ATP5MC3,NDUFB1,ATP12A,SDHD,NDUFA12,NDUFA11,NDUFB9,NDUFB3,SDHA
ko00190	Oxidative phosphorylation	0.87376770021561	-0.134940727881809	120	102	0.0161904761904762	6300	7161	9550,4706,51382,4724,4718,7384,4710,10632,496,4695,127124,6391,514,1355,90423,4731,1340,155066,9377,7385,4725,526,170712,4726,1347,7386,533,539,56901,535,1351,5464,51079,506,245973,10312,4712,29796,516,440567,4696,4704,7381,4717,8992,51606,9167,4705,23545,4719,518,50617,9114,6392,479,55967,4707,126328,4715,4709,6389,1327,4698,27068,522,245972,1350,513,4702,1345,509,4714,4728,4720,515,1329,10476,374291,495,6390,10975,341947,1346,1339,1337,523,529,4729,4697,525,528,1352,1353,4716,517,4711,4708,4700,64077,498,4723,4722	ATP6V1G1,NDUFAB1,ATP6V1D,NDUFS4,NDUFC2,UQCRC1,NDUFB4,ATP5MG,ATP4B,NDUFA2,ATP6V1G3,SDHC,ATP5F1E,COX15,ATP6V1E2,NDUFV3,COX6B1,ATP6V0E2,COX5A,UQCRC2,NDUFS5,ATP6V1B2,COX7B2,NDUFS6,COX7A2,UQCRFS1,ATP6V0B,ATP5PO,NDUFA4L2,ATP6V0A1,COX8A,PPA1,NDUFA13,ATP5F1B,ATP6V1C2,TCIRG1,NDUFB6,UQCR10,ATP5MC1,UQCRHL,NDUFA3,NDUFA9,UQCRB,NDUFC1,ATP6V0E1,ATP6V1H,COX7A2L,NDUFA10,ATP6V0A2,NDUFS1,ATP5MC3,ATP6V0A4,ATP6V0D1,SDHD,ATP12A,NDUFA12,NDUFB1,NDUFA11,NDUFB9,NDUFB3,SDHA,COX4I1,NDUFA5,PPA2,ATP5PF,ATP6V0D2,COX7C,ATP5F1D,NDUFA8,COX6C,ATP5F1C,NDUFB8,NDUFS8,NDUFS2,ATP5PB,COX5B,ATP5PD,NDUFS7,ATP4A,SDHB,UQCR11,COX8C,COX7A1,COX6A2,COX6A1,ATP6V1A,ATP6V1E1,NDUFV2,NDUFA4,ATP6V1B1,ATP6V1C1,COX10,COX11,NDUFB10,ATP5MC2,NDUFB5,NDUFB2,NDUFA6,LHPP,ATP5F1A,NDUFV1,NDUFS3
hsa_M00043	Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine	0.879765395899925	-0.128100002621068	1	1	0.000158730158730159	6300	7161	7173	TPO
M00043	Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine	0.879765395899925	-0.128100002621068	1	1	0.000158730158730159	6300	7161	7173	TPO
M00091	Phosphatidylcholine (PC) biosynthesis, PE => PC	0.879765395899925	-0.128100002621068	1	1	0.000158730158730159	6300	7161	10400	PEMT
hsa00472	D-Arginine and D-ornithine metabolism	0.879765395899925	-0.128100002621068	1	1	0.000158730158730159	6300	7161	1610	DAO
ko00472	D-Arginine and D-ornithine metabolism	0.879765395899925	-0.128100002621068	1	1	0.000158730158730159	6300	7161	1610	DAO
hsa_M00091	Phosphatidylcholine (PC) biosynthesis, PE => PC	0.879765395899925	-0.128100002621068	1	1	0.000158730158730159	6300	7161	10400	PEMT
ko00240	Pyrimidine metabolism	0.884991656160864	-0.122177062085472	104	88	0.013968253968254	6300	7161	5430,5558,171568,30833,5427,318,978,957,7083,7298,221264,4831,10622,4860,10587,7371,51082,1806,10714,6241,654364,1635,129607,84618,5433,9533,5432,661,955,548644,83549,1854,953,55703,246721,84172,51251,5439,5167,5169,9583,5441,5557,124583,84265,10201,7372,23649,55718,79077,51727,56655,5440,56953,57804,1807,956,54107,93034,29922,5434,50484,4832,4833,4907,7378,6240,790,51728,1503,5424,11128,7084,25885,151531,5431,1723,87178,221830,7296,114112,51733,1633,4830,10623,64425,54963,22978	POLR2A,PRIM2,POLR3H,NT5C,POLE2,NUDT2,CDA,ENTPD5,TK1,TYMS,AK9,NME2,POLR3G,PNP,TXNRD2,UCK2,POLR1D,DPYD,POLD3,RRM2,NME1-NME2,DCTD,CMPK2,NT5C1A,POLR2D,POLR1C,POLR2C,POLR3D,ENTPD6,POLR2J3,UCK1,DUT,ENTPD1,POLR3B,POLR2J2,POLR1B,NT5C3A,POLR2J,ENPP1,ENPP3,ENTPD4,POLR2L,PRIM1,CANT1,POLR3GL,NME6,UMPS,POLA2,POLR3E,DCTPP1,CMPK1,POLE4,POLR2K,NT5M,POLD4,DPYS,ENTPD3,POLE3,NT5C1B,NME7,POLR2E,RRM2B,NME3,NME4,NT5E,UPP1,RRM1,CAD,POLR3K,CTPS1,POLD1,POLR3A,TK2,POLR1A,UPP2,POLR2B,DHODH,PNPT1,POLR1F,TXNRD1,TXNRD3,UPB1,DCK,NME1,POLR3C,POLR1E,UCKL1,NT5C2
hsa00240	Pyrimidine metabolism	0.884991656160864	-0.122177062085472	104	88	0.013968253968254	6300	7161	4860,4831,10622,7298,221264,957,7083,171568,5430,5558,318,978,30833,5427,129607,84618,654364,1635,10714,1806,6241,10587,51082,7371,51251,246721,84172,1854,953,83549,548644,55703,5433,9533,5432,661,955,84265,10201,9583,5441,5169,5557,124583,5439,5167,56953,57804,56655,5440,55718,51727,79077,7372,23649,50484,4832,4833,29922,93034,5434,1807,956,54107,1503,5424,51728,6240,790,7378,4907,64425,10623,54963,22978,114112,51733,4830,1633,1723,221830,7296,87178,11128,7084,25885,5431,151531	PNP,NME2,POLR3G,TYMS,AK9,ENTPD5,TK1,POLR3H,POLR2A,PRIM2,NUDT2,CDA,NT5C,POLE2,CMPK2,NT5C1A,NME1-NME2,DCTD,POLD3,DPYD,RRM2,TXNRD2,POLR1D,UCK2,NT5C3A,POLR2J2,POLR1B,DUT,ENTPD1,UCK1,POLR2J3,POLR3B,POLR2D,POLR1C,POLR2C,POLR3D,ENTPD6,POLR3GL,NME6,ENTPD4,POLR2L,ENPP3,PRIM1,CANT1,POLR2J,ENPP1,NT5M,POLD4,POLE4,POLR2K,POLR3E,CMPK1,DCTPP1,UMPS,POLA2,RRM2B,NME3,NME4,NME7,NT5C1B,POLR2E,DPYS,ENTPD3,POLE3,CTPS1,POLD1,POLR3K,RRM1,CAD,UPP1,NT5E,POLR1E,POLR3C,UCKL1,NT5C2,TXNRD3,UPB1,NME1,DCK,DHODH,POLR1F,TXNRD1,PNPT1,POLR3A,TK2,POLR1A,POLR2B,UPP2
M00037	Melatonin biosynthesis, tryptophan => serotonin => melatonin	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	1644,15,7166,121278	DDC,AANAT,TPH1,TPH2
M00307	Pyruvate oxidation, pyruvate => acetyl-CoA	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	1738,5162,5161,1737	DLD,PDHB,PDHA2,DLAT
hsa_M00037	Melatonin biosynthesis, tryptophan => serotonin => melatonin	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	7166,121278,15,1644	TPH1,TPH2,AANAT,DDC
hsa_M00386	Cul4-DDB1-CSA complex	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	1642,9978,8451,1161	DDB1,RBX1,CUL4A,ERCC8
M00079	Keratan sulfate degradation	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	2720,2799,2588,3074	GLB1,GNS,GALNS,HEXB
M00385	Cul4-DDB1-DDB2 complex	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	1643,1642,9978,8451	DDB2,DDB1,RBX1,CUL4A
hsa_M00307	Pyruvate oxidation, pyruvate => acetyl-CoA	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	5161,1737,1738,5162	PDHA2,DLAT,DLD,PDHB
hsa_M00385	Cul4-DDB1-DDB2 complex	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	1643,1642,9978,8451	DDB2,DDB1,RBX1,CUL4A
M00386	Cul4-DDB1-CSA complex	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	1161,9978,8451,1642	ERCC8,RBX1,CUL4A,DDB1
hsa_M00079	Keratan sulfate degradation	0.887224594364258	-0.119657121999891	5	4	0.000634920634920635	6300	7161	2720,2799,2588,3074	GLB1,GNS,GALNS,HEXB
hsa_M00296	BER complex	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	10038,27343,143,5423,7515,142,10039,3980	PARP2,POLL,PARP4,POLB,XRCC1,PARP1,PARP3,LIG3
M00391	Exosome, eukaryotes	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	5393,51010,23404,118460,11340,56915,22894,23016	EXOSC9,EXOSC3,EXOSC2,EXOSC6,EXOSC8,EXOSC5,DIS3,EXOSC7
ko00920	Sulfur metabolism	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	54205,54928,9060,6821,9061,58472,7263,10380	CYCS,BPNT2,PAPSS2,SUOX,PAPSS1,SQOR,TST,BPNT1
M00351	Spliceosome, U1-snRNP	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	6637,6636,6626,6631,6633,6625,6628,6635	SNRPG,SNRPF,SNRPA,SNRPC,SNRPD2,SNRNP70,SNRPB,SNRPE
hsa_M00351	Spliceosome, U1-snRNP	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	6626,6636,6635,6625,6633,6628,6631,6637	SNRPA,SNRPF,SNRPE,SNRNP70,SNRPD2,SNRPB,SNRPC,SNRPG
hsa_M00391	Exosome, eukaryotes	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	11340,56915,22894,23016,5393,51010,118460,23404	EXOSC8,EXOSC5,DIS3,EXOSC7,EXOSC9,EXOSC3,EXOSC6,EXOSC2
M00095	C5 isoprenoid biosynthesis, mevalonate pathway	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	39,10654,3157,3156,3422,4597,4598,38	ACAT2,PMVK,HMGCS1,HMGCR,IDI1,MVD,MVK,ACAT1
M00296	BER complex	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	10038,3980,7515,10039,5423,142,143,27343	PARP2,LIG3,XRCC1,PARP3,POLB,PARP1,PARP4,POLL
hsa00920	Sulfur metabolism	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	6821,9060,7263,10380,9061,58472,54205,54928	SUOX,PAPSS2,TST,BPNT1,PAPSS1,SQOR,CYCS,BPNT2
hsa_M00095	C5 isoprenoid biosynthesis, mevalonate pathway	0.890956879231254	-0.115459248606967	10	8	0.00126984126984127	6300	7161	10654,39,3157,4598,38,3156,3422,4597	PMVK,ACAT2,HMGCS1,MVK,ACAT1,HMGCR,IDI1,MVD
ko03420	Nucleotide excision repair	0.895672930961252	-0.110179965057072	47	39	0.00619047619047619	6300	7161	8451,9978,3978,7508,5981,2074,2968,10714,2965,2068,6118,1643,728340,1022,5984,1642,2071,54107,2067,2967,404672,57804,5424,56655,4331,1161,6117,6119,5985,5886,902,5111,5982,5983,7507,5887,2073,2072,5427	CUL4A,RBX1,LIG1,XPC,RFC1,ERCC6,GTF2H4,POLD3,GTF2H1,ERCC2,RPA2,DDB2,GTF2H2C,CDK7,RFC4,DDB1,ERCC3,POLE3,ERCC1,GTF2H3,GTF2H5,POLD4,POLD1,POLE4,MNAT1,ERCC8,RPA1,RPA3,RFC5,RAD23A,CCNH,PCNA,RFC2,RFC3,XPA,RAD23B,ERCC5,ERCC4,POLE2
hsa03420	Nucleotide excision repair	0.895672930961252	-0.110179965057072	47	39	0.00619047619047619	6300	7161	4331,6117,1161,56655,404672,2967,5424,57804,2067,2072,5887,2073,5427,7507,5886,5985,5983,5111,902,5982,6119,7508,9978,3978,8451,54107,6118,2071,1642,1643,728340,1022,5984,2068,2074,5981,2965,10714,2968	MNAT1,RPA1,ERCC8,POLE4,GTF2H5,GTF2H3,POLD1,POLD4,ERCC1,ERCC4,RAD23B,ERCC5,POLE2,XPA,RAD23A,RFC5,RFC3,PCNA,CCNH,RFC2,RPA3,XPC,RBX1,LIG1,CUL4A,POLE3,RPA2,ERCC3,DDB1,DDB2,GTF2H2C,CDK7,RFC4,ERCC2,ERCC6,RFC1,GTF2H1,POLD3,GTF2H4
hsa01230	Biosynthesis of amino acids	0.898328922265609	-0.107218994598676	74	62	0.00984126984126984	6300	7161	1491,1431,6472,2026,113675,65263,5224,6120,587,2597,27430,2027,5723,2805,5315,29968,3418,5232,50,7167,501,729020,221823,229,48,586,5214,3420,4144,435,2023,445,226,6470,6898,383,2752,5832,5313,5091,29920,162417,95,4143,384,4548,51166,1373,5211,84706,875,5831,5223,3417,84076,2806,3419,10993,6888,22934,5053,7086	CTH,CS,SHMT2,ENO2,SDSL,PYCR3,PGAM2,RPE,BCAT2,GAPDH,MAT2B,ENO3,PSPH,GOT1,PKM,PSAT1,IDH2,PGK2,ACO2,TPI1,ALDH7A1,RPEL1,PRPS1L1,ALDOB,ACO1,BCAT1,PFKP,IDH3B,MAT2A,ASL,ENO1,ASS1,ALDOA,SHMT1,TAT,ARG1,GLUL,ALDH18A1,PKLR,PC,PYCR2,NAGS,ACY1,MAT1A,ARG2,MTR,AADAT,CPS1,PFKL,GPT2,CBS,PYCR1,PGAM1,IDH1,TKTL2,GOT2,IDH3A,SDS,TALDO1,RPIA,PAH,TKT
ko01230	Biosynthesis of amino acids	0.898328922265609	-0.107218994598676	74	62	0.00984126984126984	6300	7161	5214,48,586,229,221823,729020,501,7167,50,445,2023,435,4144,3420,2805,2027,5723,27430,2597,587,6120,5224,65263,113675,6472,2026,1431,1491,5232,3418,5315,29968,84076,3417,5223,5831,875,84706,5211,1373,51166,4548,7086,5053,22934,6888,10993,3419,2806,2752,5832,383,6898,6470,226,384,4143,95,162417,29920,5313,5091	PFKP,ACO1,BCAT1,ALDOB,PRPS1L1,RPEL1,ALDH7A1,TPI1,ACO2,ASS1,ENO1,ASL,MAT2A,IDH3B,GOT1,ENO3,PSPH,MAT2B,GAPDH,BCAT2,RPE,PGAM2,PYCR3,SDSL,SHMT2,ENO2,CS,CTH,PGK2,IDH2,PKM,PSAT1,TKTL2,IDH1,PGAM1,PYCR1,CBS,GPT2,PFKL,CPS1,AADAT,MTR,TKT,PAH,RPIA,TALDO1,SDS,IDH3A,GOT2,GLUL,ALDH18A1,ARG1,TAT,SHMT1,ALDOA,ARG2,MAT1A,ACY1,NAGS,PYCR2,PKLR,PC
M00154	Cytochrome c oxidase	0.901352144368538	-0.103859260473806	21	17	0.0026984126984127	6300	7161	1329,1345,1337,1340,9377,1350,1355,341947,1353,9167,1352,1339,1346,1351,170712,1327,1347	COX5B,COX6C,COX6A1,COX6B1,COX5A,COX7C,COX15,COX8C,COX11,COX7A2L,COX10,COX6A2,COX7A1,COX8A,COX7B2,COX4I1,COX7A2
hsa_M00154	Cytochrome c oxidase	0.901352144368538	-0.103859260473806	21	17	0.0026984126984127	6300	7161	1350,1355,341947,1353,1352,9167,1339,1346,1351,170712,1327,1347,1329,1345,1337,1340,9377	COX7C,COX15,COX8C,COX11,COX10,COX7A2L,COX6A2,COX7A1,COX8A,COX7B2,COX4I1,COX7A2,COX5B,COX6C,COX6A1,COX6B1,COX5A
hsa_M00340	Proteasome, 20S core particle	0.90380512713228	-0.101141509159486	15	12	0.0019047619047619	6300	7161	5691,5687,5695,5690,5692,5693,5694,5686,5685,5682,5684,143471	PSMB3,PSMA6,PSMB7,PSMB2,PSMB4,PSMB5,PSMB6,PSMA5,PSMA4,PSMA1,PSMA3,PSMA8
M00340	Proteasome, 20S core particle	0.90380512713228	-0.101141509159486	15	12	0.0019047619047619	6300	7161	5692,5693,5695,5690,5687,5691,5694,5686,5682,5685,143471,5684	PSMB4,PSMB5,PSMB7,PSMB2,PSMA6,PSMB3,PSMB6,PSMA5,PSMA1,PSMA4,PSMA8,PSMA3
hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	0.90380512713228	-0.101141509159486	15	12	0.0019047619047619	6300	7161	4668,8706,6489,127550,53947,6483,6482,3074,10317,10690,2524,26301	NAGA,B3GALNT1,ST8SIA1,A3GALT2,A4GALT,ST3GAL2,ST3GAL1,HEXB,B3GALT5,FUT9,FUT2,GBGT1
hsa03008	Ribosome biogenesis in eukaryotes	0.913241825794009	-0.0907545640240449	79	66	0.0104761904761905	6300	7161	1459,79631,29889,55131,51077,55226,10607,23160,51096,138716,55813,54433,3692,1457,92856,4931,23195,84135,55127,54913,5901,55272,55341,9790,26354,83732,7514,65083,5822,51367,51602,84916,134430,6949,10799,10885,57455,6023,10775,28987,10199,166378,22803,643802,51068,55781,23560,10482,10248,84128,283106,10556,29107,10940,25996,9724,4809,2091,10171,81691,27341,10528,55651,54464,51119,29102	CSNK2A2,EFL1,GNL2,RBM28,FCF1,NAT10,TBL3,WDR43,UTP18,RPP25L,UTP6,GAR1,EIF6,CSNK2A1,IMP4,NVL,MDN1,UTP15,HEATR1,RPP25,RAN,IMP3,LSG1,BMS1,GNL3,RIOK1,XPO1,NOL6,PWP2,POP5,NOP58,UTP4,WDR36,TCOF1,RPP40,WDR3,REXO1,RMRP,POP4,NOB1,MPHOSPH10,AFG2A,XRN2,MPHOSPH10P1,NMD3,RIOK2,GTPBP4,NXF1,POP7,WDR75,CSNK2A3,RPP30,NXT1,POP1,REXO2,UTP14C,SNU13,FBL,RCL1,REXO5,RRP7A,NOP56,NHP2,XRN1,SBDS,DROSHA
ko03008	Ribosome biogenesis in eukaryotes	0.913241825794009	-0.0907545640240449	79	66	0.0104761904761905	6300	7161	51602,51367,5822,83732,7514,55341,26354,9790,65083,54913,5901,55272,23195,84135,4931,55127,54433,1457,92856,3692,138716,51096,55813,51077,55226,10607,23160,79631,29889,1459,55131,54464,29102,51119,81691,27341,10528,55651,10940,29107,10556,10171,4809,9724,25996,2091,10248,10482,283106,84128,643802,23560,55781,51068,10199,166378,22803,10799,10885,57455,10775,28987,6023,84916,134430,6949	NOP58,POP5,PWP2,RIOK1,XPO1,LSG1,GNL3,BMS1,NOL6,RPP25,RAN,IMP3,MDN1,UTP15,NVL,HEATR1,GAR1,CSNK2A1,IMP4,EIF6,RPP25L,UTP18,UTP6,FCF1,NAT10,TBL3,WDR43,EFL1,GNL2,CSNK2A2,RBM28,XRN1,DROSHA,SBDS,REXO5,RRP7A,NOP56,NHP2,POP1,NXT1,RPP30,RCL1,SNU13,UTP14C,REXO2,FBL,POP7,NXF1,CSNK2A3,WDR75,MPHOSPH10P1,GTPBP4,RIOK2,NMD3,MPHOSPH10,AFG2A,XRN2,RPP40,WDR3,REXO1,POP4,NOB1,RMRP,UTP4,WDR36,TCOF1
hsa_M00078	Heparan sulfate degradation	0.916467825067524	-0.0872283186279214	9	7	0.00111111111111111	6300	7161	138050,6448,3425,10855,2799,2990,60495	HGSNAT,SGSH,IDUA,HPSE,GNS,GUSB,HPSE2
M00078	Heparan sulfate degradation	0.916467825067524	-0.0872283186279214	9	7	0.00111111111111111	6300	7161	60495,6448,3425,2990,2799,10855,138050	HPSE2,SGSH,IDUA,GUSB,GNS,HPSE,HGSNAT
M00352	Spliceosome, U2-snRNP	0.917009820702272	-0.0866370971840318	20	16	0.00253968253968254	6300	7161	10291,6633,6635,10262,23451,84844,6627,10992,11325,6628,51639,10946,6637,6629,83443,6636	SF3A1,SNRPD2,SNRPE,SF3B4,SF3B1,PHF5A,SNRPA1,SF3B2,DDX42,SNRPB,SF3B6,SF3A3,SNRPG,SNRPB2,SF3B5,SNRPF
hsa_M00352	Spliceosome, U2-snRNP	0.917009820702272	-0.0866370971840318	20	16	0.00253968253968254	6300	7161	10262,6635,6633,10291,10992,6627,84844,23451,11325,10946,51639,6628,6637,83443,6629,6636	SF3B4,SNRPE,SNRPD2,SF3A1,SF3B2,SNRPA1,PHF5A,SF3B1,DDX42,SF3A3,SF3B6,SNRPB,SNRPG,SF3B5,SNRPB2,SNRPF
ko04978	Mineral absorption	0.920939478344393	-0.0823609578671375	51	42	0.00666666666666667	6300	7161	490,2495,478,483,645745,4493,4490,4495,6523,140803,4489,6546,30061,2512,7018,481,79901,476,261729,4501,4499,7779,4494,54822,3163,3162,1811,486,7421,4891,477,26872,482,115019,6550,4502,10568,1317,475,340024,55503,480	ATP2B1,FTH1,ATP1A3,ATP1B3,MT1HL1,MT1E,MT1B,MT1G,SLC5A1,TRPM6,MT1A,SLC8A1,SLC40A1,FTL,TF,ATP1B1,CYBRD1,ATP1A1,STEAP2,MT1X,MT1M,SLC30A1,MT1F,TRPM7,HMOX2,HMOX1,SLC26A3,FXYD2,VDR,SLC11A2,ATP1A2,STEAP1,ATP1B2,SLC26A9,SLC9A3,MT2A,SLC34A2,SLC31A1,ATOX1,SLC6A19,TRPV6,ATP1A4
hsa04978	Mineral absorption	0.920939478344393	-0.0823609578671375	51	42	0.00666666666666667	6300	7161	4501,261729,7018,79901,481,476,30061,2512,4489,6546,140803,4493,4490,6523,4495,2495,490,483,478,645745,10568,1317,475,340024,55503,480,4502,6550,26872,477,482,115019,7421,4891,3163,3162,486,1811,54822,4494,4499,7779	MT1X,STEAP2,TF,CYBRD1,ATP1B1,ATP1A1,SLC40A1,FTL,MT1A,SLC8A1,TRPM6,MT1E,MT1B,SLC5A1,MT1G,FTH1,ATP2B1,ATP1B3,ATP1A3,MT1HL1,SLC34A2,SLC31A1,ATOX1,SLC6A19,TRPV6,ATP1A4,MT2A,SLC9A3,STEAP1,ATP1A2,ATP1B2,SLC26A9,VDR,SLC11A2,HMOX2,HMOX1,FXYD2,SLC26A3,TRPM7,MT1F,MT1M,SLC30A1
hsa_M00055	N-glycan precursor biosynthesis	0.922374749197172	-0.0808036855134721	14	11	0.00174603174603175	6300	7161	199857,144245,85365,10195,79053,79796,84920,56052,79087,29880,29929	ALG14,ALG10B,ALG2,ALG3,ALG8,ALG9,ALG10,ALG1,ALG12,ALG5,ALG6
M00353	Spliceosome, Prp19/CDC5L complex	0.922374749197172	-0.0808036855134721	14	11	0.00174603174603175	6300	7161	51503,3304,10286,988,5356,3305,3312,56259,3310,51729,3306	CWC15,HSPA1B,BCAS2,CDC5L,PLRG1,HSPA1L,HSPA8,CTNNBL1,HSPA6,WBP11,HSPA2
hsa_M00353	Spliceosome, Prp19/CDC5L complex	0.922374749197172	-0.0808036855134721	14	11	0.00174603174603175	6300	7161	51503,3304,10286,5356,988,3305,56259,3312,3310,51729,3306	CWC15,HSPA1B,BCAS2,PLRG1,CDC5L,HSPA1L,CTNNBL1,HSPA8,HSPA6,WBP11,HSPA2
M00147	NADH dehydrogenase (ubiquinone) 1 beta subcomplex	0.922374749197172	-0.0808036855134721	14	11	0.00174603174603175	6300	7161	4716,4714,4709,4717,4708,4711,4712,4707,4715,4718,4710	NDUFB10,NDUFB8,NDUFB3,NDUFC1,NDUFB2,NDUFB5,NDUFB6,NDUFB1,NDUFB9,NDUFC2,NDUFB4
M00055	N-glycan precursor biosynthesis	0.922374749197172	-0.0808036855134721	14	11	0.00174603174603175	6300	7161	29929,29880,79087,56052,84920,79796,79053,10195,85365,144245,199857	ALG6,ALG5,ALG12,ALG1,ALG10,ALG9,ALG8,ALG3,ALG2,ALG10B,ALG14
hsa_M00147	NADH dehydrogenase (ubiquinone) 1 beta subcomplex	0.922374749197172	-0.0808036855134721	14	11	0.00174603174603175	6300	7161	4717,4707,4716,4711,4708,4718,4710,4715,4712,4709,4714	NDUFC1,NDUFB1,NDUFB10,NDUFB5,NDUFB2,NDUFC2,NDUFB4,NDUFB9,NDUFB6,NDUFB3,NDUFB8
hsa_M00288	RPA complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	6117,6118,6119	RPA1,RPA2,RPA3
M00006	Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	5226,25796,9563	PGD,PGLS,H6PD
hsa_M00263	DNA polymerase epsilon complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	56655,5427,54107	POLE4,POLE2,POLE3
M00262	DNA polymerase delta complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	57804,5424,10714	POLD4,POLD1,POLD3
M00288	RPA complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	6118,6119,6117	RPA2,RPA3,RPA1
hsa_M00006	Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	9563,25796,5226	H6PD,PGLS,PGD
hsa_M00261	DNA polymerase alpha / primase complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	5557,23649,5558	PRIM1,POLA2,PRIM2
hsa00471	D-Glutamine and D-glutamate metabolism	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	2744,2746,27165	GLS,GLUD1,GLS2
hsa_M00262	DNA polymerase delta complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	10714,57804,5424	POLD3,POLD4,POLD1
ko00471	D-Glutamine and D-glutamate metabolism	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	27165,2746,2744	GLS2,GLUD1,GLS
M00263	DNA polymerase epsilon complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	54107,5427,56655	POLE3,POLE2,POLE4
M00402	Translocon-associated protein (TRAP) complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	6746,6747,6745	SSR2,SSR3,SSR1
M00261	DNA polymerase alpha / primase complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	5558,23649,5557	PRIM2,POLA2,PRIM1
hsa_M00402	Translocon-associated protein (TRAP) complex	0.926589991613944	-0.0762441072515943	4	3	0.000476190476190476	6300	7161	6745,6746,6747	SSR1,SSR2,SSR3
ko03020	RNA polymerase	0.929325150878218	-0.0732966004590041	31	25	0.00396825396825397	6300	7161	11128,51082,5431,25885,5439,5434,221830,5441,64425,84265,10623,171568,5432,9533,5433,5430,661,55718,548644,55703,10622,51728,246721,5440,84172	POLR3A,POLR1D,POLR2B,POLR1A,POLR2J,POLR2E,POLR1F,POLR2L,POLR1E,POLR3GL,POLR3C,POLR3H,POLR2C,POLR1C,POLR2D,POLR2A,POLR3D,POLR3E,POLR2J3,POLR3B,POLR3G,POLR3K,POLR2J2,POLR2K,POLR1B
hsa03020	RNA polymerase	0.929325150878218	-0.0732966004590041	31	25	0.00396825396825397	6300	7161	661,5430,9533,5433,171568,5432,55703,548644,55718,84172,5440,246721,51728,10622,25885,5431,51082,11128,221830,5434,5439,5441,10623,84265,64425	POLR3D,POLR2A,POLR1C,POLR2D,POLR3H,POLR2C,POLR3B,POLR2J3,POLR3E,POLR1B,POLR2K,POLR2J2,POLR3K,POLR3G,POLR1A,POLR2B,POLR1D,POLR3A,POLR1F,POLR2E,POLR2J,POLR2L,POLR3C,POLR3GL,POLR1E
M00409	ESCRT-I complex	0.939014518434641	-0.062924338301666	8	6	0.000952380952380952	6300	7161	93343,55048,89853,79720,7251,137492	MVB12A,VPS37C,MVB12B,VPS37B,TSG101,VPS37A
ko04122	Sulfur relay system	0.939014518434641	-0.062924338301666	8	6	0.000952380952380952	6300	7161	81605,348180,90353,4338,7263,27304	URM1,CTU2,CTU1,MOCS2,TST,MOCS3
hsa04122	Sulfur relay system	0.939014518434641	-0.062924338301666	8	6	0.000952380952380952	6300	7161	4338,7263,27304,348180,81605,90353	MOCS2,TST,MOCS3,CTU2,URM1,CTU1
hsa_M00409	ESCRT-I complex	0.939014518434641	-0.062924338301666	8	6	0.000952380952380952	6300	7161	79720,7251,137492,93343,55048,89853	VPS37B,TSG101,VPS37A,MVB12A,VPS37C,MVB12B
hsa_M00428	eIF4F complex	0.939014518434641	-0.062924338301666	8	6	0.000952380952380952	6300	7161	1982,1981,1977,8672,9470,1974	EIF4G2,EIF4G1,EIF4E,EIF4G3,EIF4E2,EIF4A2
M00428	eIF4F complex	0.939014518434641	-0.062924338301666	8	6	0.000952380952380952	6300	7161	1981,1974,1977,1982,9470,8672	EIF4G1,EIF4A2,EIF4E,EIF4G2,EIF4E2,EIF4G3
ko04977	Vitamin digestion and absorption	0.940148140335428	-0.0617178200335295	24	19	0.00301587301587302	6300	7161	5948,686,335,8884,2694,55788,5406,337,949,9963,4363,10560,9227,113278,2346,338,8029,151056,80704	RBP2,BTD,APOA1,SLC5A6,CBLIF,LMBRD1,PNLIP,APOA4,SCARB1,SLC23A1,ABCC1,SLC19A2,LRAT,SLC52A3,FOLH1,APOB,CUBN,PLB1,SLC19A3
hsa04977	Vitamin digestion and absorption	0.940148140335428	-0.0617178200335295	24	19	0.00301587301587302	6300	7161	80704,2346,151056,8029,338,9227,113278,4363,9963,10560,949,5406,337,2694,55788,335,8884,686,5948	SLC19A3,FOLH1,PLB1,CUBN,APOB,LRAT,SLC52A3,ABCC1,SLC23A1,SLC19A2,SCARB1,PNLIP,APOA4,CBLIF,LMBRD1,APOA1,SLC5A6,BTD,RBP2
M00412	ESCRT-III complex	0.953442880788866	-0.0476757605195967	12	9	0.00142857142857143	6300	7161	51510,51652,57132,5119,92421,91782,25978,128866,79643	CHMP5,CHMP3,CHMP1B,CHMP1A,CHMP4C,CHMP7,CHMP2B,CHMP4B,CHMP6
hsa_M00412	ESCRT-III complex	0.953442880788866	-0.0476757605195967	12	9	0.00142857142857143	6300	7161	25978,91782,92421,5119,51510,51652,57132,79643,128866	CHMP2B,CHMP7,CHMP4C,CHMP1A,CHMP5,CHMP3,CHMP1B,CHMP6,CHMP4B
M00182	RNA polymerase I, eukaryotes	0.953442880788866	-0.0476757605195967	12	9	0.00142857142857143	6300	7161	5440,51082,25885,84172,5441,9533,5434,221830,64425	POLR2K,POLR1D,POLR1A,POLR1B,POLR2L,POLR1C,POLR2E,POLR1F,POLR1E
hsa_M00182	RNA polymerase I, eukaryotes	0.953442880788866	-0.0476757605195967	12	9	0.00142857142857143	6300	7161	5434,221830,64425,5440,51082,25885,84172,5441,9533	POLR2E,POLR1F,POLR1E,POLR2K,POLR1D,POLR1A,POLR1B,POLR2L,POLR1C
M00337	Immunoproteasome	0.955288950570739	-0.0457414182226221	17	13	0.00206349206349206	6300	7161	5691,5687,5698,5690,5692,5686,5699,5685,5682,5696,5720,5684,143471	PSMB3,PSMA6,PSMB9,PSMB2,PSMB4,PSMA5,PSMB10,PSMA4,PSMA1,PSMB8,PSME1,PSMA3,PSMA8
hsa_M00337	Immunoproteasome	0.955288950570739	-0.0457414182226221	17	13	0.00206349206349206	6300	7161	5692,5690,5698,5687,5691,5699,5686,5682,5685,143471,5684,5720,5696	PSMB4,PSMB2,PSMB9,PSMA6,PSMB3,PSMB10,PSMA5,PSMA1,PSMA4,PSMA8,PSMA3,PSME1,PSMB8
hsa_M00003	Gluconeogenesis, oxaloacetate => fructose-6P	0.955288950570739	-0.0457414182226221	17	13	0.00206349206349206	6300	7161	8789,2023,5232,2203,5105,2026,7167,5224,226,2597,5223,229,2027	FBP2,ENO1,PGK2,FBP1,PCK1,ENO2,TPI1,PGAM2,ALDOA,GAPDH,PGAM1,ALDOB,ENO3
M00003	Gluconeogenesis, oxaloacetate => fructose-6P	0.955288950570739	-0.0457414182226221	17	13	0.00206349206349206	6300	7161	8789,2203,5232,2023,5224,226,2026,7167,5105,229,2027,2597,5223	FBP2,FBP1,PGK2,ENO1,PGAM2,ALDOA,ENO2,TPI1,PCK1,ALDOB,ENO3,GAPDH,PGAM1
hsa_M00092	Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE	0.958229351349709	-0.0426681232450997	7	5	0.000793650793650794	6300	7161	55500,10390,55224,1119,5833	ETNK1,CEPT1,ETNK2,CHKA,PCYT2
hsa_M00398	Sm core complex	0.958229351349709	-0.0426681232450997	7	5	0.000793650793650794	6300	7161	6628,6633,6635,6636,6637	SNRPB,SNRPD2,SNRPE,SNRPF,SNRPG
M00398	Sm core complex	0.958229351349709	-0.0426681232450997	7	5	0.000793650793650794	6300	7161	6633,6628,6635,6637,6636	SNRPD2,SNRPB,SNRPE,SNRPG,SNRPF
M00092	Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE	0.958229351349709	-0.0426681232450997	7	5	0.000793650793650794	6300	7161	1119,55224,10390,55500,5833	CHKA,ETNK2,CEPT1,ETNK1,PCYT2
M00020	Serine biosynthesis, glycerate-3P => serine	0.960140898420733	-0.0406752361015355	3	2	0.000317460317460317	6300	7161	5723,29968	PSPH,PSAT1
hsa_M00020	Serine biosynthesis, glycerate-3P => serine	0.960140898420733	-0.0406752361015355	3	2	0.000317460317460317	6300	7161	5723,29968	PSPH,PSAT1
ko03013	RNA transport	0.96118810518944	-0.039585150155362	166	139	0.0220634920634921	6300	7161	8665,4686,4116,8761,11102,10189,1207,96764,11097,50628,51367,8021,8637,1974,91181,10250,80145,57510,51095,1981,5903,9470,6613,22985,6612,8664,8487,1975,8890,79902,129401,10605,81929,138716,22794,60528,26986,8086,10940,9688,53371,5042,10482,387082,55706,22916,6396,9972,9883,348995,728689,1917,10762,26019,8661,57122,8672,84321,11260,94026,1967,6606,8892,8893,51068,10073,8666,5901,1983,54913,8668,1982,10460,51808,23225,132430,11218,23636,55110,9631,285190,84305,7341,8894,1965,7514,10284,23165,84220,4928,3646,79023,23279,1915,79833,23191,1978,80336,10419,10209,79760,10289,10556,8662,29107,1977,9984,8087,10248,727851,11171,26999,7175,8563,8891,100101267,9775,1979,3837,10799,5976,5905,10775,4927,653489,8669,25929,23511,400966,9818,59343,9669,8667,79897,6607,7329,9513,55520,55746	EIF3F,NCBP1,MAGOH,PABPC4,RPP14,ALYREF,CLNS1A,TGS1,NUP42,GEMIN4,POP5,NUP214,EIF4EBP3,EIF4A2,NUP210L,SRRM1,THOC7,XPO5,TRNT1,EIF4G1,RANBP2,EIF4E2,SUMO2,ACIN1,SUMO3,EIF3D,GEMIN2,EIF4B,EIF2B4,NUP85,NUP35,PAIP1,SEH1L,RPP25L,CASC3,ELAC2,PABPC1,AAAS,POP1,NUP93,NUP54,PABPC3,NXF1,SUMO4,NDC1,NCBP2,SEC13,NUP153,POM121,NUP43,EIF3CL,EEF1A2,NUP50,UPF2,EIF3A,NUP107,EIF4G3,THOC3,XPOT,POM121L2,EIF2B1,SMN1,EIF2B2,EIF2B5,NMD3,SNUPN,EIF3G,RAN,EIF5,RPP25,EIF3I,EIF4G2,TACC3,PHAX,NUP210,PABPC4L,DDX20,NUP62,MAGOHB,NUP155,RGPD4,PYM1,SUMO1,EIF2S2,EIF2S1,XPO1,SAP18,NUP205,RGPD5,NUP98,EIF3E,NUP37,NUP160,EEF1A1,GEMIN6,CYFIP1,EIF4EBP1,PABPC1L,PRMT5,EIF1,GEMIN7,EIF1B,RPP30,EIF3B,NXT1,EIF4E,THOC1,FXR1,POP7,RGPD8,STRAP,CYFIP2,TPR,THOC5,EIF2B3,POM121C,EIF4A3,EIF4EBP2,KPNB1,RPP40,UPF1,RANGAP1,POP4,NUP88,RGPD3,EIF3J,GEMIN5,NUP188,RGPD1,NUP58,SENP2,EIF5B,EIF3H,RPP21,SMN2,UBE2I,FXR2,ELAC1,NUP133
hsa03013	RNA transport	0.96118810518944	-0.039585150155362	166	139	0.0220634920634921	6300	7161	5903,1981,57510,51095,22985,6613,6612,9470,8664,1975,8487,129401,8890,79902,10605,81929,138716,22794,60528,26986,8665,4686,4116,8761,11102,10189,1207,11097,50628,96764,51367,8021,91181,80145,10250,8637,1974,26019,10762,57122,8661,11260,84321,8672,1967,94026,6606,8892,8893,51068,8666,10073,10940,8086,9688,5042,53371,10482,387082,22916,55706,6396,9972,9883,728689,1917,348995,79023,23279,1915,79833,1978,23191,80336,10419,10209,79760,10289,5901,1983,54913,8668,1982,51808,10460,132430,11218,23225,55110,23636,285190,84305,9631,7341,10284,7514,8894,1965,4928,84220,3646,23165,10799,10775,5976,5905,23511,25929,8669,653489,4927,400966,9818,8667,9669,59343,79897,6607,55746,55520,7329,9513,8662,29107,10556,1977,10248,727851,9984,8087,11171,8563,8891,26999,7175,100101267,1979,9775,3837	RANBP2,EIF4G1,XPO5,TRNT1,ACIN1,SUMO2,SUMO3,EIF4E2,EIF3D,EIF4B,GEMIN2,NUP35,EIF2B4,NUP85,PAIP1,SEH1L,RPP25L,CASC3,ELAC2,PABPC1,EIF3F,NCBP1,MAGOH,PABPC4,RPP14,ALYREF,CLNS1A,NUP42,GEMIN4,TGS1,POP5,NUP214,NUP210L,THOC7,SRRM1,EIF4EBP3,EIF4A2,UPF2,NUP50,NUP107,EIF3A,XPOT,THOC3,EIF4G3,EIF2B1,POM121L2,SMN1,EIF2B2,EIF2B5,NMD3,EIF3G,SNUPN,POP1,AAAS,NUP93,PABPC3,NUP54,NXF1,SUMO4,NCBP2,NDC1,SEC13,NUP153,POM121,EIF3CL,EEF1A2,NUP43,NUP37,NUP160,EEF1A1,GEMIN6,EIF4EBP1,CYFIP1,PABPC1L,PRMT5,EIF1,GEMIN7,EIF1B,RAN,EIF5,RPP25,EIF3I,EIF4G2,PHAX,TACC3,PABPC4L,DDX20,NUP210,MAGOHB,NUP62,RGPD4,PYM1,NUP155,SUMO1,SAP18,XPO1,EIF2S2,EIF2S1,NUP98,RGPD5,EIF3E,NUP205,RPP40,POP4,UPF1,RANGAP1,NUP188,GEMIN5,EIF3J,RGPD3,NUP88,RGPD1,NUP58,EIF3H,EIF5B,SENP2,RPP21,SMN2,NUP133,ELAC1,UBE2I,FXR2,EIF3B,NXT1,RPP30,EIF4E,POP7,RGPD8,THOC1,FXR1,STRAP,THOC5,EIF2B3,CYFIP2,TPR,POM121C,EIF4EBP2,EIF4A3,KPNB1
hsa_M00682	Notch signaling	0.965089947218494	-0.0355339724340477	16	12	0.0019047619047619	6300	7161	54567,6868,83464,3516,4853,5664,10683,4855,23385,5663,4854,51107	DLL4,ADAM17,APH1B,RBPJ,NOTCH2,PSEN2,DLL3,NOTCH4,NCSTN,PSEN1,NOTCH3,APH1A
M00682	Notch signaling	0.965089947218494	-0.0355339724340477	16	12	0.0019047619047619	6300	7161	5663,4854,51107,4853,5664,10683,4855,23385,6868,83464,3516,54567	PSEN1,NOTCH3,APH1A,NOTCH2,PSEN2,DLL3,NOTCH4,NCSTN,ADAM17,APH1B,RBPJ,DLL4
hsa_M00101	Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol	0.965790414020094	-0.0348084310215508	11	8	0.00126984126984127	6300	7161	10826,7108,6309,1718,51478,6307,1595,1717	FAXDC2,TM7SF2,SC5D,DHCR24,HSD17B7,MSMO1,CYP51A1,DHCR7
M00101	Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol	0.965790414020094	-0.0348084310215508	11	8	0.00126984126984127	6300	7161	1595,1717,6307,6309,51478,10826,7108,1718	CYP51A1,DHCR7,MSMO1,SC5D,HSD17B7,FAXDC2,TM7SF2,DHCR24
hsa00220	Arginine biosynthesis	0.967114384993117	-0.0334385020102955	21	16	0.00253968253968254	6300	7161	2805,2752,4842,2746,383,84706,27165,1373,445,384,162417,2744,435,95,2806,4846	GOT1,GLUL,NOS1,GLUD1,ARG1,GPT2,GLS2,CPS1,ASS1,ARG2,NAGS,GLS,ASL,ACY1,GOT2,NOS3
ko00220	Arginine biosynthesis	0.967114384993117	-0.0334385020102955	21	16	0.00253968253968254	6300	7161	2744,162417,435,95,445,384,2806,4846,2746,383,2805,4842,2752,27165,1373,84706	GLS,NAGS,ASL,ACY1,ASS1,ARG2,GOT2,NOS3,GLUD1,ARG1,GOT1,NOS1,GLUL,GLS2,CPS1,GPT2
ko00440	Phosphonate and phosphinate metabolism	0.973824617596516	-0.026524055622368	6	4	0.000634920634920635	6300	7161	56994,10390,5130,5833	CHPT1,CEPT1,PCYT1A,PCYT2
M00090	Phosphatidylcholine (PC) biosynthesis, choline => PC	0.973824617596516	-0.026524055622368	6	4	0.000634920634920635	6300	7161	10390,56994,1119,5130	CEPT1,CHPT1,CHKA,PCYT1A
hsa00440	Phosphonate and phosphinate metabolism	0.973824617596516	-0.026524055622368	6	4	0.000634920634920635	6300	7161	56994,10390,5130,5833	CHPT1,CEPT1,PCYT1A,PCYT2
hsa_M00090	Phosphatidylcholine (PC) biosynthesis, choline => PC	0.973824617596516	-0.026524055622368	6	4	0.000634920634920635	6300	7161	5130,1119,56994,10390	PCYT1A,CHKA,CHPT1,CEPT1
hsa_M00152	Cytochrome bc1 complex	0.975993365360488	-0.0242994903785347	10	7	0.00111111111111111	6300	7161	7386,7384,440567,10975,7385,29796,7381	UQCRFS1,UQCRC1,UQCRHL,UQCR11,UQCRC2,UQCR10,UQCRB
M00152	Cytochrome bc1 complex	0.975993365360488	-0.0242994903785347	10	7	0.00111111111111111	6300	7161	7386,7384,7381,7385,29796,10975,440567	UQCRFS1,UQCRC1,UQCRB,UQCRC2,UQCR10,UQCR11,UQCRHL
ko00030	Pentose phosphate pathway	0.977961504794863	-0.0222849708724372	30	23	0.00365079365079365	6300	7161	2203,5226,414328,6120,226,22934,55276,7086,8789,6888,729020,51071,221823,132158,229,25796,84076,5214,64080,9563,5236,5211,2821	FBP1,PGD,IDNK,RPE,ALDOA,RPIA,PGM2,TKT,FBP2,TALDO1,RPEL1,DERA,PRPS1L1,GLYCTK,ALDOB,PGLS,TKTL2,PFKP,RBKS,H6PD,PGM1,PFKL,GPI
hsa00030	Pentose phosphate pathway	0.977961504794863	-0.0222849708724372	30	23	0.00365079365079365	6300	7161	8789,6888,22934,55276,7086,64080,2821,5236,9563,5211,221823,132158,729020,51071,84076,5214,229,25796,5226,2203,6120,226,414328	FBP2,TALDO1,RPIA,PGM2,TKT,RBKS,GPI,PGM1,H6PD,PFKL,PRPS1L1,GLYCTK,RPEL1,DERA,TKTL2,PFKP,ALDOB,PGLS,PGD,FBP1,RPE,ALDOA,IDNK
hsa_M00180	RNA polymerase II, eukaryotes	0.980398913662882	-0.019795735383789	14	10	0.00158730158730159	6300	7161	5430,246721,5433,5441,5432,5431,5440,5439,548644,5434	POLR2A,POLR2J2,POLR2D,POLR2L,POLR2C,POLR2B,POLR2K,POLR2J,POLR2J3,POLR2E
M00389	APC/C complex	0.980398913662882	-0.019795735383789	14	10	0.00158730158730159	6300	7161	51433,51529,991,996,51343,8697,29945,10393,64682,51434	ANAPC5,ANAPC11,CDC20,CDC27,FZR1,CDC23,ANAPC4,ANAPC10,ANAPC1,ANAPC7
M00180	RNA polymerase II, eukaryotes	0.980398913662882	-0.019795735383789	14	10	0.00158730158730159	6300	7161	5432,5441,5433,246721,5430,5440,5431,5439,548644,5434	POLR2C,POLR2L,POLR2D,POLR2J2,POLR2A,POLR2K,POLR2B,POLR2J,POLR2J3,POLR2E
hsa_M00389	APC/C complex	0.980398913662882	-0.019795735383789	14	10	0.00158730158730159	6300	7161	991,996,51529,51433,64682,51434,8697,29945,10393,51343	CDC20,CDC27,ANAPC11,ANAPC5,ANAPC1,ANAPC7,CDC23,ANAPC4,ANAPC10,FZR1
ko04612	Antigen processing and presentation	0.980900749215325	-0.0192839976081782	77	62	0.00984126984126984	6300	7161	3118,4261,4801,3109,7124,3308,3107,3305,3802,115653,3133,3106,926,3326,3458,5720,6890,4802,567,821,3312,3824,5994,1385,10197,1508,3304,3809,3112,3113,6891,920,5641,811,3811,3805,3823,5993,8625,3135,10437,3320,3127,972,3111,3108,3105,3119,3122,3123,3306,4800,6892,3812,1520,3134,1514,3117,3310,3804,3309,3821	HLA-DQA2,CIITA,NFYB,HLA-DMB,TNF,HSPA4,HLA-C,HSPA1L,KIR2DL1,KIR3DL3,HLA-E,HLA-B,CD8B,HSP90AB1,IFNG,PSME1,TAP1,NFYC,B2M,CANX,HSPA8,KLRD1,RFXAP,CREB1,PSME3,CTSB,HSPA1B,KIR2DS4,HLA-DOB,HLA-DPA1,TAP2,CD4,LGMN,CALR,KIR3DL1,KIR2DL4,KLRC3,RFX5,RFXANK,HLA-G,IFI30,HSP90AA1,HLA-DRB5,CD74,HLA-DOA,HLA-DMA,HLA-A,HLA-DQB1,HLA-DRA,HLA-DRB1,HSPA2,NFYA,TAPBP,KIR3DL2,CTSS,HLA-F,CTSL,HLA-DQA1,HSPA6,KIR2DL3,HSPA5,KLRC1
hsa04612	Antigen processing and presentation	0.980900749215325	-0.0192839976081782	77	62	0.00984126984126984	6300	7161	3309,3804,3821,1520,3812,3117,3310,1514,3134,3123,3122,3119,6892,4800,3306,972,3105,3108,3111,3135,8625,5993,3823,3127,3320,10437,3805,811,3811,5641,920,6891,3113,3112,1385,10197,3809,3304,1508,821,567,5994,3824,3312,6890,4802,3326,5720,3458,3106,3133,926,3305,3107,3308,115653,3802,4801,4261,7124,3109,3118	HSPA5,KIR2DL3,KLRC1,CTSS,KIR3DL2,HLA-DQA1,HSPA6,CTSL,HLA-F,HLA-DRB1,HLA-DRA,HLA-DQB1,TAPBP,NFYA,HSPA2,CD74,HLA-A,HLA-DMA,HLA-DOA,HLA-G,RFXANK,RFX5,KLRC3,HLA-DRB5,HSP90AA1,IFI30,KIR2DL4,CALR,KIR3DL1,LGMN,CD4,TAP2,HLA-DPA1,HLA-DOB,CREB1,PSME3,KIR2DS4,HSPA1B,CTSB,CANX,B2M,RFXAP,KLRD1,HSPA8,TAP1,NFYC,HSP90AB1,PSME1,IFNG,HLA-B,HLA-E,CD8B,HSPA1L,HLA-C,HSPA4,KIR3DL3,KIR2DL1,NFYB,CIITA,TNF,HLA-DMB,HLA-DQA2
M00151	Cytochrome bc1 complex respiratory unit	0.985558413469579	-0.0145468812189116	2	1	0.000158730158730159	6300	7161	7386	UQCRFS1
M00106	Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate	0.985558413469579	-0.0145468812189116	2	1	0.000158730158730159	6300	7161	570	BAAT
hsa_M00151	Cytochrome bc1 complex respiratory unit	0.985558413469579	-0.0145468812189116	2	1	0.000158730158730159	6300	7161	7386	UQCRFS1
hsa_M00106	Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate	0.985558413469579	-0.0145468812189116	2	1	0.000158730158730159	6300	7161	570	BAAT
hsa_M00405	THC complex	0.985638087488128	-0.0144660429883718	5	3	0.000476190476190476	6300	7161	80145,8563,9984	THOC7,THOC5,THOC1
M00405	THC complex	0.985638087488128	-0.0144660429883718	5	3	0.000476190476190476	6300	7161	8563,9984,80145	THOC5,THOC1,THOC7
hsa05034	Alcoholism	0.985777660714518	-0.0143244460403406	180	149	0.0236507936507937	6300	7161	10681,10488,121504,3021,1392,3012,5894,3013,91860,8349,2771,399694,135,8347,10645,673,5173,8360,8368,2030,8968,94239,2906,8343,2885,9586,55766,111,5501,468,4915,9734,2784,7054,51564,126961,94235,3845,3017,53358,5594,84152,55970,221613,805,3018,8969,64764,2791,92815,4893,8354,2905,8362,116443,8363,8334,4852,653604,51806,8290,6570,8340,8348,2786,1644,9555,5604,5595,5569,6464,8367,810,128312,8335,51764,808,163688,440689,2904,1388,90993,116444,2354,8355,8341,6571,1386,3066,8520,8970,8357,79885,84699,5499,6654,59345,1812,1813,3265,8359,8365,2788,8346,8339,2903,55506,801,2790,2773,83933,8332,627,10014,8370,8364,8353,8352,6655,8841,6531,3015,8344,5500,814,84254,2783,2782,723790,3020,8345,8366,2778,2770,136,25759,2792,2793,440093,2787,148327,54331,1385,3065,9759,5566,8361,8358,8350	GNB5,CREB3,H4C16,H3-3B,CRH,H2AC8,RAF1,H2AC7,CALML4,H2BC21,GNAI2,SHC4,ADORA2A,H2BC4,CAMKK2,BRAF,PDYN,H4C4,H4C13,SLC29A1,H3C7,H2AZ2,GRIN2D,H2BC7,GRB2,CREB5,H2AJ,ADCY5,PPP1CC,ATF4,NTRK2,HDAC9,GNB3,TH,HDAC7,H3C14,GNG8,KRAS,H2BC5,SHC3,MAPK1,PPP1R1B,GNG12,H2AC1,CALM2,H2BC3,H2AC11,CREB3L2,GNG11,H2AC25,NRAS,H3C11,GRIN2C,H4C12,GRIN3A,H4C11,H2AC6,NPY,H3C13,CALML5,H3-4,SLC18A1,H2BC13,H2BC17,GNG4,DDC,MACROH2A1,MAP2K1,MAPK3,PKIA,SHC1,H4C5,CALML3,H2BC26,H2AC4,GNG13,CALM3,CALML6,H2BC18,GRIN2B,ATF6B,CREB3L1,GRIN3B,FOSB,H3C8,H2BC15,SLC18A2,ATF2,HDAC2,HAT1,H2BC11,H3C10,HDAC11,CREB3L3,PPP1CA,SOS1,GNB4,DRD1,DRD2,HRAS,H4C1,H4C8,GNG7,H2BC10,H2BC8,GRIN2A,MACROH2A2,CALM1,GNG10,GNAI3,HDAC10,H2AC16,BDNF,HDAC5,H4C14,H4C3,H3C6,H3C3,SOS2,HDAC3,SLC6A3,H2AZ1,H2BC6,PPP1CB,CAMK4,CAMKK1,GNB2,GNB1,H2AC19,H3-3A,H2BC9,H4C2,GNAS,GNAI1,ADORA2B,SHC2,GNGT1,GNGT2,H3-5,GNG5,CREB3L4,GNG2,CREB1,HDAC1,HDAC4,PRKACA,H4C6,H3C2,H3C1
ko05034	Alcoholism	0.985777660714518	-0.0143244460403406	180	149	0.0236507936507937	6300	7161	6531,8841,8344,3015,5500,2782,2783,84254,814,8366,8345,3020,723790,2787,440093,2793,2792,25759,136,2770,2778,148327,8350,8358,5566,9759,8361,3065,1385,54331,3066,1386,6571,8341,5499,84699,79885,8970,8357,8520,8359,3265,1813,1812,59345,6654,801,55506,2903,8346,8339,8365,2788,2773,2790,8364,10014,8370,627,83933,8332,6655,8352,8353,84152,5594,55970,53358,92815,2791,64764,8969,3018,805,221613,8354,4893,51806,653604,4852,8334,8363,8362,116443,2905,2786,8348,8340,6570,8290,8367,6464,5569,5595,5604,1644,9555,2904,440689,51764,163688,808,8335,128312,810,8355,2354,116444,90993,1388,3021,121504,10681,10488,135,2771,399694,8349,91860,5894,3013,3012,1392,5173,10645,673,8347,8368,8360,8343,2906,94239,8968,2030,111,55766,9586,2885,9734,2784,4915,468,5501,3017,3845,94235,126961,7054,51564	SLC6A3,HDAC3,H2BC6,H2AZ1,PPP1CB,GNB1,GNB2,CAMKK1,CAMK4,H4C2,H2BC9,H3-3A,H2AC19,GNG5,H3-5,GNGT2,GNGT1,SHC2,ADORA2B,GNAI1,GNAS,CREB3L4,H3C1,H3C2,PRKACA,HDAC4,H4C6,HDAC1,CREB1,GNG2,HDAC2,ATF2,SLC18A2,H2BC15,PPP1CA,CREB3L3,HDAC11,H2BC11,H3C10,HAT1,H4C1,HRAS,DRD2,DRD1,GNB4,SOS1,CALM1,MACROH2A2,GRIN2A,H2BC10,H2BC8,H4C8,GNG7,GNAI3,GNG10,H4C3,HDAC5,H4C14,BDNF,HDAC10,H2AC16,SOS2,H3C3,H3C6,PPP1R1B,MAPK1,GNG12,SHC3,H2AC25,GNG11,CREB3L2,H2AC11,H2BC3,CALM2,H2AC1,H3C11,NRAS,CALML5,H3C13,NPY,H2AC6,H4C11,H4C12,GRIN3A,GRIN2C,GNG4,H2BC17,H2BC13,SLC18A1,H3-4,H4C5,SHC1,PKIA,MAPK3,MAP2K1,DDC,MACROH2A1,GRIN2B,H2BC18,GNG13,CALML6,CALM3,H2AC4,H2BC26,CALML3,H3C8,FOSB,GRIN3B,CREB3L1,ATF6B,H3-3B,H4C16,GNB5,CREB3,ADORA2A,GNAI2,SHC4,H2BC21,CALML4,RAF1,H2AC7,H2AC8,CRH,PDYN,CAMKK2,BRAF,H2BC4,H4C13,H4C4,H2BC7,GRIN2D,H2AZ2,H3C7,SLC29A1,ADCY5,H2AJ,CREB5,GRB2,HDAC9,GNB3,NTRK2,ATF4,PPP1CC,H2BC5,KRAS,GNG8,H3C14,TH,HDAC7
hsa_M00406	TREX complex	0.990254072892164	-0.00979372949471569	8	5	0.000793650793650794	6300	7161	80145,9984,10189,8563,84321	THOC7,THOC1,ALYREF,THOC5,THOC3
M00406	TREX complex	0.990254072892164	-0.00979372949471569	8	5	0.000793650793650794	6300	7161	9984,84321,8563,10189,80145	THOC1,THOC3,THOC5,ALYREF,THOC7
ko03010	Ribosome	0.991347414815835	-0.00869023614209186	134	109	0.0173015873015873	6300	7161	6189,6208,6223,63875,219927,25873,6152,6133,6164,51263,64979,6157,6229,6128,6182,6183,6137,9553,6146,6139,6165,29093,140801,51187,6227,55052,6159,6230,6202,6129,3921,200916,23521,10573,6166,124995,6228,51318,64963,51121,6161,28998,4736,6138,6130,6144,79590,6123,6122,6188,6209,55168,6207,64968,6232,29088,6233,6205,9045,6124,6142,6181,64960,6143,6217,6234,9349,6175,65003,6136,64969,6125,64983,6156,6204,64965,51021,63931,6168,6160,51065,65008,6235,55173,51264,6167,64928,54460,6155,11224,6135,6231,6169,51073,100529239,7311,6224,11222,51373,6210,6176,6201,54948,51023,64981,9801,6194,6154,6206	RPS3A,RPS14,RPS19,MRPL17,MRPL21,RPL36,RPL24,RPL9,RPL34,MRPL30,MRPL36,RPL27A,RPS24,RPL6,MRPL12,MRPS12,RPL13,MRPL33,RPL22,RPL17,RPL35A,MRPL22,RPL10L,RSL24D1,RPS21,MRPL20,RPL29,RPS25,RPS8,RPL7,RPSA,RPL22L1,RPL13A,MRPL28,RPL36AL,MRPL10,RPS23,MRPL35,MRPS11,RPL26L1,RPL32,MRPL13,RPL10A,RPL15,RPL7A,RPL21,MRPL24,RPL3L,RPL3,RPS3,RPS15,MRPS18A,RPS13,MRPS6,RPS27,MRPL15,RPS27A,RPS11,RPL14,RPL4,RPL18A,RPLP2,MRPS15,RPL19,RPS16,RPS28,RPL23,RPLP0,MRPL11,RPL12,MRPS5,RPL5,MRPL32,RPL30,RPS10,MRPS9,MRPS16,MRPS14,RPL37A,RPL31,RPS27L,MRPL1,RPS29,MRPS10,MRPL27,RPL37,MRPL14,MRPS21,RPL27,RPL35,RPL11,RPS26,RPL38,MRPL4,RPS10-NUDT3,UBA52,RPS20,MRPL3,MRPS17,RPS15A,RPLP1,RPS7,MRPL16,MRPS18C,MRPL34,MRPL19,RPS6,RPL26,RPS12
hsa03010	Ribosome	0.991347414815835	-0.00869023614209186	134	109	0.0173015873015873	6300	7161	6167,51264,55173,64928,11224,6155,54460,7311,100529239,51073,6169,6135,6231,6210,6176,6201,51373,6224,11222,51023,54948,9801,6194,64981,6206,6154,6124,9045,6205,64960,6143,6181,6142,9349,6234,6217,65003,6175,6136,6204,6156,64983,6125,64969,51065,6160,6168,63931,64965,51021,6235,65008,200916,3921,6129,6202,6228,124995,6166,10573,23521,28998,6161,51121,51318,64963,6130,6138,4736,79590,6144,55168,6209,6188,6122,6123,64968,6207,29088,6233,6232,6208,6189,219927,63875,6223,6152,25873,51263,6164,6133,6229,6157,64979,9553,6137,6183,6182,6128,51187,140801,29093,6165,6146,6139,6230,6159,55052,6227	RPL37,MRPL27,MRPS10,MRPL14,RPL35,RPL27,MRPS21,UBA52,RPS10-NUDT3,MRPL4,RPL38,RPL11,RPS26,RPS15A,RPLP1,RPS7,MRPS17,RPS20,MRPL3,MRPS18C,MRPL16,MRPL19,RPS6,MRPL34,RPS12,RPL26,RPL4,RPL14,RPS11,MRPS15,RPL19,RPLP2,RPL18A,RPL23,RPS28,RPS16,MRPL11,RPLP0,RPL12,RPS10,RPL30,MRPL32,RPL5,MRPS5,RPS27L,RPL31,RPL37A,MRPS14,MRPS9,MRPS16,RPS29,MRPL1,RPL22L1,RPSA,RPL7,RPS8,RPS23,MRPL10,RPL36AL,MRPL28,RPL13A,MRPL13,RPL32,RPL26L1,MRPL35,MRPS11,RPL7A,RPL15,RPL10A,MRPL24,RPL21,MRPS18A,RPS15,RPS3,RPL3,RPL3L,MRPS6,RPS13,MRPL15,RPS27A,RPS27,RPS14,RPS3A,MRPL21,MRPL17,RPS19,RPL24,RPL36,MRPL30,RPL34,RPL9,RPS24,RPL27A,MRPL36,MRPL33,RPL13,MRPS12,MRPL12,RPL6,RSL24D1,RPL10L,MRPL22,RPL35A,RPL22,RPL17,RPS25,RPL29,MRPL20,RPS21
M00425	H/ACA ribonucleoprotein complex	0.993691805233324	-0.00632817549984221	4	2	0.000317460317460317	6300	7161	54433,55651	GAR1,NHP2
M00390	Exosome, archaea	0.993691805233324	-0.00632817549984221	4	2	0.000317460317460317	6300	7161	23404,23016	EXOSC2,EXOSC7
hsa_M00425	H/ACA ribonucleoprotein complex	0.993691805233324	-0.00632817549984221	4	2	0.000317460317460317	6300	7161	55651,54433	NHP2,GAR1
hsa_M00390	Exosome, archaea	0.993691805233324	-0.00632817549984221	4	2	0.000317460317460317	6300	7161	23016,23404	EXOSC7,EXOSC2
hsa_M00177	Ribosome, eukaryotes	0.995027868496425	-0.00498453367665504	91	72	0.0114285714285714	6300	7161	6165,6160,6168,6139,6146,51065,51187,140801,6227,6235,6230,6159,6157,6136,6229,6128,6125,6156,6137,6204,6234,6217,25873,6152,9349,6133,6175,6164,9045,6205,6208,6189,6124,6142,6223,6181,6143,6194,6207,6154,6232,6233,6206,6144,6224,6176,6210,6201,6209,6123,6188,6122,6161,11224,51121,6155,6169,6231,6135,4736,6138,6130,100529239,7311,6129,6202,3921,200916,6167,23521,6228,6166	RPL35A,RPL31,RPL37A,RPL17,RPL22,RPS27L,RSL24D1,RPL10L,RPS21,RPS29,RPS25,RPL29,RPL27A,RPL12,RPS24,RPL6,RPL5,RPL30,RPL13,RPS10,RPS28,RPS16,RPL36,RPL24,RPL23,RPL9,RPLP0,RPL34,RPL14,RPS11,RPS14,RPS3A,RPL4,RPL18A,RPS19,RPLP2,RPL19,RPS6,RPS13,RPL26,RPS27,RPS27A,RPS12,RPL21,RPS20,RPLP1,RPS15A,RPS7,RPS15,RPL3L,RPS3,RPL3,RPL32,RPL35,RPL26L1,RPL27,RPL38,RPS26,RPL11,RPL10A,RPL15,RPL7A,RPS10-NUDT3,UBA52,RPL7,RPS8,RPSA,RPL22L1,RPL37,RPL13A,RPS23,RPL36AL
M00177	Ribosome, eukaryotes	0.995027868496425	-0.00498453367665504	91	72	0.0114285714285714	6300	7161	6135,4736,6231,6138,6130,6169,100529239,7311,6155,51121,6161,11224,23521,6166,6228,6202,6129,6167,3921,200916,6154,6206,6232,6233,6207,6194,6123,6188,6122,6209,6144,6224,6210,6176,6201,6175,6133,6164,6217,6234,25873,9349,6152,6181,6142,6223,6143,6189,9045,6205,6208,6124,6227,6235,6159,6230,6146,6139,6165,6168,6160,140801,51187,51065,6128,6156,6125,6204,6137,6157,6136,6229	RPL11,RPL10A,RPS26,RPL15,RPL7A,RPL38,RPS10-NUDT3,UBA52,RPL27,RPL26L1,RPL32,RPL35,RPL13A,RPL36AL,RPS23,RPS8,RPL7,RPL37,RPSA,RPL22L1,RPL26,RPS12,RPS27,RPS27A,RPS13,RPS6,RPL3L,RPS3,RPL3,RPS15,RPL21,RPS20,RPS15A,RPLP1,RPS7,RPLP0,RPL9,RPL34,RPS16,RPS28,RPL36,RPL23,RPL24,RPLP2,RPL18A,RPS19,RPL19,RPS3A,RPL14,RPS11,RPS14,RPL4,RPS21,RPS29,RPL29,RPS25,RPL22,RPL17,RPL35A,RPL37A,RPL31,RPL10L,RSL24D1,RPS27L,RPL6,RPL30,RPL5,RPS10,RPL13,RPL27A,RPL12,RPS24
M00135	GABA biosynthesis, eukaryotes, putrescine => GABA	0.997936782545785	-0.00206534881949844	9	5	0.000793650793650794	6300	7161	223,501,217,219,224	ALDH9A1,ALDH7A1,ALDH2,ALDH1B1,ALDH3A2
hsa_M00135	GABA biosynthesis, eukaryotes, putrescine => GABA	0.997936782545785	-0.00206534881949844	9	5	0.000793650793650794	6300	7161	223,501,217,219,224	ALDH9A1,ALDH7A1,ALDH2,ALDH1B1,ALDH3A2
hsa_M00392	Ski complex	0.998267170994219	-0.00173433209060603	3	1	0.000158730158730159	6300	7161	9652	SKIC3
M00005	PRPP biosynthesis, ribose 5P => PRPP	0.998267170994219	-0.00173433209060603	3	1	0.000158730158730159	6300	7161	221823	PRPS1L1
M00392	Ski complex	0.998267170994219	-0.00173433209060603	3	1	0.000158730158730159	6300	7161	9652	SKIC3
hsa_M00005	PRPP biosynthesis, ribose 5P => PRPP	0.998267170994219	-0.00173433209060603	3	1	0.000158730158730159	6300	7161	221823	PRPS1L1
ko03015	mRNA surveillance pathway	0.999101617847019	-0.000898785940082129	91	70	0.0111111111111111	6300	7161	10767,5529,51585,5521,51692,56903,2935,1479,5976,5526,29101,26019,8731,2107,10978,9887,79869,5527,11052,55339,5500,22916,8189,5519,5523,9775,55012,5522,23293,4440,8106,8732,29107,10898,5516,81608,10482,5042,80336,5518,5501,5515,100529063,23049,53981,26986,22794,390748,53918,23283,22985,80335,26528,10189,84305,64895,10250,5520,5528,5525,10284,4116,23381,4686,55110,124540,10914,5499,132430,8761	HBS1L,PPP2R5E,PCF11,PPP2R2B,CPSF3,PAPOLB,GSPT1,CSTF3,UPF1,PPP2R5B,SSU72,UPF2,RNMT,ETF1,CLP1,SMG7,CPSF7,PPP2R5C,CPSF6,WDR33,PPP1CB,NCBP2,SYMPK,PPP2R1B,PPP2R3A,EIF4A3,PPP2R3C,PPP2R2C,SMG6,MSI1,PABPN1,RNGTT,NXT1,CPSF4,PPP2CB,FIP1L1,NXF1,PABPC3,PABPC1L,PPP2R1A,PPP1CC,PPP2CA,BCL2L2-PABPN1,SMG1,CPSF2,PABPC1,CASC3,PABPN1L,PELO,CSTF2T,ACIN1,WDR82,DAZAP1,ALYREF,PYM1,PAPOLG,SRRM1,PPP2R2A,PPP2R5D,PPP2R5A,SAP18,MAGOH,SMG5,NCBP1,MAGOHB,MSI2,PAPOLA,PPP1CA,PABPC4L,PABPC4
hsa03015	mRNA surveillance pathway	0.999101617847019	-0.000898785940082129	91	70	0.0111111111111111	6300	7161	5515,5501,5518,23049,100529063,80336,22794,390748,53981,26986,53918,22985,26528,80335,23283,64895,10189,84305,10284,5525,5528,5520,10250,23381,4686,4116,132430,8761,124540,55110,5499,10914,5529,10767,56903,51692,5521,51585,2107,26019,8731,29101,10978,2935,5976,5526,1479,11052,79869,9887,5527,22916,5500,55339,5519,55012,9775,5522,5523,8189,29107,23293,4440,8106,8732,5042,10482,10898,81608,5516	PPP2CA,PPP1CC,PPP2R1A,SMG1,BCL2L2-PABPN1,PABPC1L,CASC3,PABPN1L,CPSF2,PABPC1,PELO,ACIN1,DAZAP1,WDR82,CSTF2T,PAPOLG,ALYREF,PYM1,SAP18,PPP2R5A,PPP2R5D,PPP2R2A,SRRM1,SMG5,NCBP1,MAGOH,PABPC4L,PABPC4,MSI2,MAGOHB,PPP1CA,PAPOLA,PPP2R5E,HBS1L,PAPOLB,CPSF3,PPP2R2B,PCF11,ETF1,UPF2,RNMT,SSU72,CLP1,GSPT1,UPF1,PPP2R5B,CSTF3,CPSF6,CPSF7,SMG7,PPP2R5C,NCBP2,PPP1CB,WDR33,PPP2R1B,PPP2R3C,EIF4A3,PPP2R2C,PPP2R3A,SYMPK,NXT1,SMG6,MSI1,PABPN1,RNGTT,PABPC3,NXF1,CPSF4,FIP1L1,PPP2CB
M00430	Exon junction complex (EJC)	0.999389722277345	-0.000610464017902893	18	11	0.00174603174603175	6300	7161	10189,10250,9775,10284,22794,4116,5976,29107,26019,55110,22985	ALYREF,SRRM1,EIF4A3,SAP18,CASC3,MAGOH,UPF1,NXT1,UPF2,MAGOHB,ACIN1
hsa_M00430	Exon junction complex (EJC)	0.999389722277345	-0.000610464017902893	18	11	0.00174603174603175	6300	7161	55110,22985,4116,5976,29107,26019,10250,9775,22794,10284,10189	MAGOHB,ACIN1,MAGOH,UPF1,NXT1,UPF2,SRRM1,EIF4A3,CASC3,SAP18,ALYREF
hsa05322	Systemic lupus erythematosus	0.999936085756797	-6.39162858054695e-05	132	101	0.016031746031746	6300	7161	8970,8357,8341,720,8365,8346,8339,717,2903,3127,940,55506,958,87,8359,1991,3123,3586,712,3122,3111,3108,8353,8352,729,8332,8370,8364,3015,8344,3109,713,942,2212,715,718,440093,723790,3020,8345,8366,8361,727,8358,8350,731,3012,3013,8349,3113,3112,121504,3021,2209,8368,8360,81,730,8347,2215,6737,3119,6741,55766,735,8968,94239,8343,2214,126961,3017,716,3117,221613,3018,8969,714,7124,92815,6628,3118,8362,8363,8334,653604,732,6738,8354,9555,8367,8290,8348,8340,3458,941,1511,8355,128312,8335,2904,440689	H2BC11,H3C10,H2BC15,C4A,H4C8,H2BC10,H2BC8,C2,GRIN2A,HLA-DRB5,CD28,MACROH2A2,CD40,ACTN1,H4C1,ELANE,HLA-DRB1,IL10,C1QA,HLA-DRA,HLA-DOA,HLA-DMA,H3C6,H3C3,C6,H2AC16,H4C14,H4C3,H2AZ1,H2BC6,HLA-DMB,C1QB,CD86,FCGR2A,C1R,C3,H3-5,H2AC19,H3-3A,H2BC9,H4C2,H4C6,C5,H3C2,H3C1,C8A,H2AC8,H2AC7,H2BC21,HLA-DPA1,HLA-DOB,H4C16,H3-3B,FCGR1A,H4C13,H4C4,ACTN4,C7,H2BC4,FCGR3B,TRIM21,HLA-DQB1,SSB,H2AJ,C9,H3C7,H2AZ2,H2BC7,FCGR3A,H3C14,H2BC5,C1S,HLA-DQA1,H2AC1,H2BC3,H2AC11,C1QC,TNF,H2AC25,SNRPB,HLA-DQA2,H4C12,H4C11,H2AC6,H3C13,C8B,RO60,H3C11,MACROH2A1,H4C5,H3-4,H2BC17,H2BC13,IFNG,CD80,CTSG,H3C8,H2BC26,H2AC4,GRIN2B,H2BC18
ko05322	Systemic lupus erythematosus	0.999936085756797	-6.39162858054695e-05	132	101	0.016031746031746	6300	7161	440093,718,8345,8366,3020,723790,8361,727,8358,8350,731,3109,3015,8344,713,715,2212,942,3122,712,3123,3586,3111,3108,8352,8353,729,8364,8332,8370,8970,8357,720,8341,3127,55506,940,958,8365,2903,8339,8346,717,1991,8359,87,8367,9555,8348,8340,3458,8290,8355,1511,941,2904,440689,128312,8335,7124,714,92815,3018,221613,8969,6628,3118,8334,6738,732,653604,8363,8362,8354,6741,55766,6737,3119,94239,8343,735,8968,3017,126961,2214,3117,716,8349,3013,3012,3021,3112,3113,121504,2209,8360,8368,2215,8347,730,81	H3-5,C3,H2BC9,H4C2,H3-3A,H2AC19,H4C6,C5,H3C2,H3C1,C8A,HLA-DMB,H2AZ1,H2BC6,C1QB,C1R,FCGR2A,CD86,HLA-DRA,C1QA,HLA-DRB1,IL10,HLA-DOA,HLA-DMA,H3C3,H3C6,C6,H4C3,H2AC16,H4C14,H2BC11,H3C10,C4A,H2BC15,HLA-DRB5,MACROH2A2,CD28,CD40,H4C8,GRIN2A,H2BC8,H2BC10,C2,ELANE,H4C1,ACTN1,H4C5,MACROH2A1,H2BC17,H2BC13,IFNG,H3-4,H3C8,CTSG,CD80,GRIN2B,H2BC18,H2BC26,H2AC4,TNF,C1QC,H2AC25,H2BC3,H2AC1,H2AC11,SNRPB,HLA-DQA2,H2AC6,RO60,C8B,H3C13,H4C11,H4C12,H3C11,SSB,H2AJ,TRIM21,HLA-DQB1,H2AZ2,H2BC7,C9,H3C7,H2BC5,H3C14,FCGR3A,HLA-DQA1,C1S,H2BC21,H2AC7,H2AC8,H3-3B,HLA-DOB,HLA-DPA1,H4C16,FCGR1A,H4C4,H4C13,FCGR3B,H2BC4,C7,ACTN4
ko05206	MicroRNAs in cancer	0.99996747467548	-3.25258534800447e-05	299	240	0.0380952380952381	6300	7161	7078,574484,406947,406907,406991,574452,3371,442904,113130,406995,442891,5579,9839,9759,4363,406912,406988,442903,6624,578,27086,406957,442918,5598,8091,3667,407026,406882,406986,4170,7057,7976,595,406916,4855,5268,5582,5155,3265,406954,407033,995,6935,2744,4318,406903,5296,406918,3551,406943,57521,7431,960,27250,406976,6655,90427,9134,407034,574473,23405,406895,1029,407011,407040,5578,9493,4325,407015,5243,406891,406917,6659,1545,4893,406984,6541,7422,1870,10018,1944,7143,5605,10253,5743,442890,2146,7168,596,3690,5159,406942,406967,407032,100532731,574457,6464,2064,900,8626,672,7473,407055,11186,406883,5336,54541,406906,10642,472,407051,894,693200,100302238,1788,406908,8660,407036,3236,5581,3845,619552,406884,574476,406935,5292,407045,406956,387,4790,406890,407046,406955,4082,406951,406938,10297,406989,574461,406970,407029,406893,25,3065,407035,131405,406997,407031,23411,1786,7157,406901,5156,5728,406894,4193,993,100302282,3190,406980,406969,407017,6654,5328,10298,1869,442910,4233,1956,406923,5154,6768,1027,6774,4854,898,1871,1591,3925,4853,407016,8434,574455,100616173,406933,85414,648,406896,89780,836,406992,7042,1398,2065,407043,5594,2261,7329,406881,407030,406885,23414,5290,5962,406911,407044,27165,5604,63923,659,406915,5335,7430,2033,554213,406985,2475,4609,407021,407047,399694,1387,442900,4194,406959,994,5894,7148,8651,1026,406892,406909,9252,3162,574493,2885,406926,442898,324,1021	TIMP3,MIR520G,MIR155,MIR124-1,MIR21,MIR494,TNC,MIR335,CDCA5,MIR181A1,MIR135B,PRKCB,ZEB2,HDAC4,ABCC1,MIR125B2,MIR205,MIR331,FSCN1,BAK1,FOXP1,MIR181C,MIR373,MAPK7,HMGA2,IRS1,MIR29C,MIRLET7A2,MIR203A,MCL1,THBS1,FZD3,CCND1,MIR128-2,NOTCH4,SERPINB5,PRKCG,PDGFB,HRAS,MIR181A2,MIR30D,CDC25C,ZEB1,GLS,MMP9,MIR10B,PIK3R2,MIR129-2,IKBKB,MIR152,RPTOR,VIM,CD44,PDCD4,MIR199A1,SOS2,BMF,CCNE2,MIR30E,MIR520B,DICER1,MIR103A1,CDKN2A,MIR23B,MIR34A,PRKCA,KIF23,MMP16,MIR26A1,ABCB1,MIRLET7I,MIR129-1,SOX4,CYP1B1,NRAS,MIR200B,SLC7A1,VEGFA,E2F2,BCL2L11,EFNA3,TNR,MAP2K2,SPRY2,PTGS2,MIR133B,EZH2,TPM1,BCL2,ITGB3,PDGFRB,MIR150,MIR192,MIR30C2,COMMD3-BMI1,MIR181D,SHC1,ERBB2,CCNG1,TP63,BRCA1,WNT3,MIR99A,RASSF1,MIRLET7A3,PLCG2,DDIT4,MIR122,IGF2BP1,ATM,MIR9-3,CCND2,MIR615,MIR103B1,DNMT3A,MIR124-2,IRS2,MIR32,HOXD10,PRKCE,KRAS,MIR483,MIRLET7B,MIR520C,MIR143,PIM1,MIR7-3,MIR181B2,RHOA,NFKB1,MIRLET7G,MIR9-1,MIR181B1,MARCKS,MIR16-2,MIR146A,APC2,MIR206,MIR520E,MIR194-2,MIR30A,MIR101-1,ABL1,HDAC1,MIR31,TRIM71,MIR215,MIR30C1,SIRT1,DNMT1,TP53,MIR107,PDGFRA,PTEN,MIR101-2,MDM2,CDC25A,MIR103B2,HNRNPK,MIR19B1,MIR194-1,MIR26B,SOS1,PLAU,PAK4,E2F1,MIR345,MET,EGFR,MIR133A2,PDGFA,ST14,CDKN1B,STAT3,NOTCH3,CCNE1,E2F3,CYP24A1,STMN1,NOTCH2,MIR26A2,RECK,MIR193B,MIR203B,MIR141,SLC45A3,BMI1,MIR103A2,WNT3A,CASP3,MIR210,TGFB2,CRK,ERBB3,MIR7-1,MAPK1,FGFR3,UBE2I,MIRLET7A1,MIR30B,MIRLET7C,ZFPM2,PIK3CA,RDX,MIR125B1,MIR7-2,GLS2,MAP2K1,TNN,BMPR2,MIR128-1,PLCG1,EZR,EP300,MIR449A,MIR200C,MTOR,MYC,MIR29A,MIR9-2,SHC4,CREBBP,MIR326,MDM4,MIR183,CDC25B,RAF1,TNXB,SOCS1,CDKN1A,MIR100,MIR124-3,RPS6KA5,HMOX1,MIR520H,GRB2,MIR135A2,MIR324,APC,CDK6
hsa05206	MicroRNAs in cancer	0.99996747467548	-3.25258534800447e-05	299	240	0.0380952380952381	6300	7161	4082,407046,406955,406938,10297,406951,406970,406989,574461,406893,25,407029,3065,407035,407031,23411,1786,131405,406997,7157,406901,4193,5156,5728,406894,3190,993,100302282,6654,5328,406980,406969,407017,442910,10298,1869,1956,4233,406923,6774,1027,4854,898,6768,5154,1871,1591,3925,8434,100616173,574455,4853,407016,89780,836,406992,406933,85414,648,406896,1398,2065,407043,7042,2261,5594,406881,7329,406885,5290,23414,5962,407030,27165,659,5604,63923,407044,406911,5335,7430,2033,406915,406985,2475,4609,407021,554213,407047,406959,994,5894,399694,442900,1387,4194,8651,7148,1026,406892,3162,9252,406909,2885,406926,574493,324,1021,442898,7078,406907,574484,406947,3371,442904,406991,574452,5579,9839,113130,442891,406995,9759,4363,406912,406988,5598,407026,8091,3667,442903,578,6624,27086,442918,406957,406986,4170,7057,7976,406882,5268,5582,5155,406916,595,4855,995,6935,2744,3265,407033,406954,406943,406903,4318,5296,406918,3551,960,27250,57521,7431,90427,406976,6655,407034,9134,407040,5578,9493,23405,574473,406895,407011,1029,4325,406891,5243,407015,406984,6541,4893,7422,406917,6659,1545,1944,10018,1870,5743,442890,2146,7143,10253,5605,7168,596,406942,406967,5159,3690,100532731,574457,6464,407032,7473,2064,900,8626,672,54541,10642,406906,472,11186,407055,406883,5336,100302238,407051,894,693200,406908,1788,8660,407036,3236,406884,574476,406935,5581,3845,619552,5292,387,4790,406890,407045,406956	MARCKS,MIR9-1,MIR181B1,MIR146A,APC2,MIR16-2,MIR194-2,MIR206,MIR520E,MIR101-1,ABL1,MIR30A,HDAC1,MIR31,MIR30C1,SIRT1,DNMT1,TRIM71,MIR215,TP53,MIR107,MDM2,PDGFRA,PTEN,MIR101-2,HNRNPK,CDC25A,MIR103B2,SOS1,PLAU,MIR19B1,MIR194-1,MIR26B,MIR345,PAK4,E2F1,EGFR,MET,MIR133A2,STAT3,CDKN1B,NOTCH3,CCNE1,ST14,PDGFA,E2F3,CYP24A1,STMN1,RECK,MIR203B,MIR193B,NOTCH2,MIR26A2,WNT3A,CASP3,MIR210,MIR141,SLC45A3,BMI1,MIR103A2,CRK,ERBB3,MIR7-1,TGFB2,FGFR3,MAPK1,MIRLET7A1,UBE2I,MIRLET7C,PIK3CA,ZFPM2,RDX,MIR30B,GLS2,BMPR2,MAP2K1,TNN,MIR7-2,MIR125B1,PLCG1,EZR,EP300,MIR128-1,MIR200C,MTOR,MYC,MIR29A,MIR449A,MIR9-2,MIR183,CDC25B,RAF1,SHC4,MIR326,CREBBP,MDM4,SOCS1,TNXB,CDKN1A,MIR100,HMOX1,RPS6KA5,MIR124-3,GRB2,MIR135A2,MIR520H,APC,CDK6,MIR324,TIMP3,MIR124-1,MIR520G,MIR155,TNC,MIR335,MIR21,MIR494,PRKCB,ZEB2,CDCA5,MIR135B,MIR181A1,HDAC4,ABCC1,MIR125B2,MIR205,MAPK7,MIR29C,HMGA2,IRS1,MIR331,BAK1,FSCN1,FOXP1,MIR373,MIR181C,MIR203A,MCL1,THBS1,FZD3,MIRLET7A2,SERPINB5,PRKCG,PDGFB,MIR128-2,CCND1,NOTCH4,CDC25C,ZEB1,GLS,HRAS,MIR30D,MIR181A2,MIR152,MIR10B,MMP9,PIK3R2,MIR129-2,IKBKB,CD44,PDCD4,RPTOR,VIM,BMF,MIR199A1,SOS2,MIR30E,CCNE2,MIR34A,PRKCA,KIF23,DICER1,MIR520B,MIR103A1,MIR23B,CDKN2A,MMP16,MIRLET7I,ABCB1,MIR26A1,MIR200B,SLC7A1,NRAS,VEGFA,MIR129-1,SOX4,CYP1B1,EFNA3,BCL2L11,E2F2,PTGS2,MIR133B,EZH2,TNR,SPRY2,MAP2K2,TPM1,BCL2,MIR150,MIR192,PDGFRB,ITGB3,COMMD3-BMI1,MIR181D,SHC1,MIR30C2,WNT3,ERBB2,CCNG1,TP63,BRCA1,DDIT4,IGF2BP1,MIR122,ATM,RASSF1,MIR99A,MIRLET7A3,PLCG2,MIR103B1,MIR9-3,CCND2,MIR615,MIR124-2,DNMT3A,IRS2,MIR32,HOXD10,MIRLET7B,MIR520C,MIR143,PRKCE,KRAS,MIR483,PIM1,RHOA,NFKB1,MIRLET7G,MIR7-3,MIR181B2
hsa04740	Olfactory transduction	0.999999999959276	-4.07244324502983e-11	415	286	0.0453968253968254	6300	7161	254973,219965,403239,26735,79544,138802,26493,26248,283111,26696,81470,8386,390154,119772,341152,26341,124538,135948,390168,817,91860,390439,392390,120776,390075,130075,7932,123041,219453,57101,390191,403278,391114,442194,401992,390195,121364,219959,5137,26246,121130,219981,346517,810,26539,26529,5567,808,6546,157,805,389090,347168,128360,403282,219875,2774,26595,283159,26476,255725,26686,341416,119695,3000,5997,79295,125958,79541,219960,125963,150681,341418,26737,401994,79473,391112,23538,283365,390199,8387,403277,504189,26533,158131,26658,392391,340980,390036,8383,219473,81392,122742,81061,283160,2788,283189,390442,79290,120787,126370,390038,403284,81399,441670,390093,56656,403273,5136,390429,119774,4995,390190,81127,119682,138804,122748,81697,81696,109,256148,341799,5566,219484,26245,8390,26740,392376,282775,6543,343406,81341,219870,121129,441669,286362,403274,338675,128371,6547,119678,390321,338755,390431,138882,284433,138803,390079,408,26492,1258,401667,390326,128368,219873,4992,121275,4993,442191,219952,128366,119692,26188,219479,390067,343169,390077,219858,138799,390445,219874,26664,442186,5568,283093,392392,219983,120793,284383,346528,390084,391192,5138,254783,143503,390063,219436,393046,81050,79310,26339,392309,390155,818,391196,1262,347169,126541,390058,391109,51764,163688,390261,390064,285659,162998,390271,219956,390265,26496,815,138881,26693,390275,286365,5153,338662,51806,219958,26659,390197,441608,26534,5593,5592,26538,26219,26692,26648,119765,729759,816,441911,26212,390433,390323,138805,441639,341568,8392,390181,219986,4991,504191,391211,144124,391189,283162,134083,26333,219957,120796,801,135924,441933,122740,81285,143502,135941,127385,283092,409,390327,156,390437,219982,401665,8590,26707,119679,254786,219954,127623,143496,196335,390260,4994,219968,8388,79317,2782,26689,83988,81442,390054,1261	OR1L4,OR5B17,OR2T27,OR1L3,OR4K1,OR13C8,OR8B8,OR2K2,OR51V1,OR2T1,OR2G2,OR1D5,OR5T3,OR52M1,OR2AT4,OR5H1,OR4D2,OR2F2,OR5M1,CAMK2D,CALML4,OR11G2,OR1L6,OR2D2,OR52N5,OR9A4,OR2H2,SLC24A4,OR8K5,ANO2,OR5B12,OR5K4,OR6K3,OR10C1,OR2T2,OR5AN1,OR10A7,OR1S1,PDE1C,OR2L2,OR10P1,OR5A2,OR6V1,CALML3,OR10H1,OR12D2,PRKACB,CALM3,SLC8A1,GRK3,CALM2,OR6B2,OR1J1,OR10T2,OR6C65,OR4D5,GNAL,OR8B2,OR8D1,OR10J1,OR52B2,OR4E2,OR6C2,OR52R1,GUCY2D,RGS2,OR5H6,OR7D4,OR2A4,OR10Q1,OR1M1,OR6B3,OR6C4,OR1L1,OR14I1,OR52N1,OR6Y1,OR52A1,OR6C6,OR4D9,OR1E1,OR5K3,OR8U8,OR10G3,OR1Q1,OR7C2,OR5C1,OR52B6,OR52K1,OR1A1,OR8K3,OR2AE1,OR4L1,OR11H1,OR8D2,GNG7,OR9G4,OR11H4,OR13A1,OR52W1,OR1I1,OR51D1,OR6C68,OR4F16,OR4M1,OR10A6,OR2S2,OR5H14,PDE1A,OR4N2,OR52K2,OR3A2,OR5B2,OR4K15,OR51L1,OR13C4,OR11H6,OR2B2,OR5V1,ADCY3,OR4S1,OR6S1,PRKACA,OR5M8,OR2M4,OR1G1,OR1J2,OR13C2,OR5J2,SLC8A2,OR10R2,OR10W1,OR10G9,OR2AP1,OR4Q3,OR13C9,OR5H15,OR5AP2,OR6K6,SLC8A3,OR52E2,OR6C1,OR2AG2,OR4K2,OR1N2,OR10H5,OR13C3,OR52E8,ARRB1,OR8G2P,CNGB1,OR51A2,OR6C76,OR10Z1,OR10S1,OR1F1,OR10AD1,OR2C1,OR14J1,OR6Q1,OR6P1,OR51S1,OR1C1,OR8U3,OR52H1,OR6F1,OR52N2,OR8B12,OR13C5,OR5AU1,OR6T1,OR7C1,OR2J3,PRKACG,OR4C12,OR1K1,OR4D6,OR56A4,OR2Z1,OR2A1,OR56A5,OR2L3,PDE2A,OR6C74,OR51E1,OR51I1,OR5D14,OR2A5,OR5AC2,OR5H2,OR5K1,OR13J1,OR5T1,CAMK2G,OR2M7,CNGA4,OR1B1,OR10H4,OR51B6,OR10K1,GNG13,CALML6,OR6M1,OR51I2,OR2V2,OR7D2,OR8B3,OR9Q1,OR10G7,OR10A3,CAMK2A,OR1L8,OR2V1,OR8A1,OR13D1,PDE1B,OR8D4,CALML5,OR1S2,OR7A5,OR4D10,OR5B3,OR10G2,PRKG2,PRKG1,OR10H2,OR1J4,OR2W1,OR7E24,OR4B1,OR4F29,CAMK2B,OR10J3,OR2B6,OR4K13,OR6C75,OR13F1,OR9K2,OR8S1,OR3A3,OR5AK2,OR4D11,OR1D2,OR9G9,OR2G6,OR10A5,OR11L1,OR8B4,OR2Y1,OR7A17,OR9Q2,OR56A1,CALM1,OR9A2,OR13G1,OR4K14,OR51E2,OR52I2,OR2A14,OR10J5,OR4C13,ARRB2,OR6C70,GRK2,OR4N5,OR5A1,OR51T1,OR6A2,OR2J2,OR52J3,OR6C3,OR9I1,OR2B11,OR52B4,OR56B4,OR6X1,OR3A1,OR5B21,OR1E2,OR4K5,GNB1,OR4D1,NCALD,OR6N2,OR52A5,CNGA3
ko04740	Olfactory transduction	0.999999999959276	-4.07244324502983e-11	415	286	0.0453968253968254	6300	7161	729759,119765,26648,441911,816,26538,5592,5593,26692,26219,341568,441639,8392,138805,390181,390433,26212,390323,134083,283162,120796,219957,26333,391211,504191,4991,219986,391189,144124,81285,143502,122740,135924,441933,801,156,390327,409,283092,401665,390437,219982,127385,135941,127623,143496,119679,26707,8590,254786,219954,219968,8388,4994,79317,196335,390260,83988,26689,390054,1261,81442,2782,219952,442191,128368,219873,390326,121275,4993,4992,390067,343169,138799,219858,390077,119692,128366,219479,26188,5568,390445,26664,442186,219874,391192,346528,390084,120793,284383,5138,283093,219983,392392,79310,81050,393046,143503,254783,219436,390063,347169,1262,163688,51764,391109,390058,126541,390155,26339,392309,391196,818,138881,815,26496,390265,390275,26693,285659,390064,390261,219956,390271,162998,390197,26659,26534,441608,5153,286365,219958,51806,338662,79541,125958,79295,219960,341416,5997,3000,119695,283365,23538,391112,403277,8387,390199,341418,26737,150681,125963,79473,401994,390036,8383,340980,392391,122742,81392,219473,504189,26533,26658,158131,403284,81399,126370,390038,120787,441670,2788,283189,283160,81061,390442,79290,81127,119682,390429,5136,56656,403273,390093,390190,4995,119774,282775,392376,26740,8390,81341,343406,6543,81697,122748,138804,26245,219484,5566,341799,256148,109,81696,6547,119678,441669,121129,219870,338675,128371,403274,286362,408,26492,390079,401667,1258,390321,138803,284433,138882,338755,390431,79544,26735,138802,219965,254973,403239,390154,119772,124538,26341,341152,283111,26248,26493,81470,8386,26696,390439,390075,120776,392390,135948,91860,390168,817,57101,130075,219453,123041,7932,5137,219959,26246,390195,121364,401992,442194,390191,391114,403278,810,808,5567,26529,26539,219981,121130,346517,26595,2774,219875,389090,805,157,6546,403282,128360,347168,26686,255725,26476,283159	OR4F29,OR4B1,OR7E24,OR10J3,CAMK2B,OR10H2,PRKG1,PRKG2,OR2W1,OR1J4,OR8S1,OR9K2,OR3A3,OR13F1,OR5AK2,OR4K13,OR2B6,OR6C75,OR2Y1,OR8B4,OR56A1,OR9Q2,OR7A17,OR2G6,OR9G9,OR1D2,OR4D11,OR11L1,OR10A5,OR51E2,OR52I2,OR4K14,OR9A2,OR13G1,CALM1,GRK2,OR6C70,ARRB2,OR4C13,OR51T1,OR4N5,OR5A1,OR10J5,OR2A14,OR2B11,OR52B4,OR52J3,OR2J2,OR6A2,OR6C3,OR9I1,OR5B21,OR1E2,OR3A1,OR4K5,OR56B4,OR6X1,NCALD,OR4D1,OR52A5,CNGA3,OR6N2,GNB1,OR6Q1,OR14J1,OR10Z1,OR10S1,OR6C76,OR10AD1,OR2C1,OR1F1,OR52H1,OR6F1,OR13C5,OR8B12,OR52N2,OR51S1,OR6P1,OR8U3,OR1C1,PRKACG,OR5AU1,OR7C1,OR2J3,OR6T1,OR2L3,OR2A1,OR56A5,OR56A4,OR2Z1,PDE2A,OR4C12,OR4D6,OR1K1,OR5H2,OR5AC2,OR2A5,OR51E1,OR6C74,OR5D14,OR51I1,OR1B1,CNGA4,CALML6,GNG13,OR10K1,OR51B6,OR10H4,OR5T1,OR5K1,OR13J1,OR2M7,CAMK2G,OR1L8,CAMK2A,OR10A3,OR10G7,OR8A1,OR2V1,OR2V2,OR51I2,OR6M1,OR9Q1,OR8B3,OR7D2,OR4D10,OR7A5,OR10G2,OR5B3,PDE1B,OR13D1,OR1S2,CALML5,OR8D4,OR2A4,OR7D4,OR5H6,OR10Q1,OR6C2,RGS2,GUCY2D,OR52R1,OR6C6,OR52A1,OR6Y1,OR5K3,OR1E1,OR4D9,OR6C4,OR1L1,OR6B3,OR1M1,OR52N1,OR14I1,OR52K1,OR1A1,OR52B6,OR5C1,OR4L1,OR2AE1,OR8K3,OR8U8,OR10G3,OR7C2,OR1Q1,OR6C68,OR4F16,OR1I1,OR51D1,OR52W1,OR4M1,GNG7,OR9G4,OR8D2,OR11H1,OR11H4,OR13A1,OR4K15,OR51L1,OR4N2,PDE1A,OR2S2,OR5H14,OR10A6,OR5B2,OR3A2,OR52K2,OR5J2,OR13C2,OR1J2,OR1G1,OR10W1,OR10R2,SLC8A2,OR2B2,OR11H6,OR13C4,OR2M4,OR5M8,PRKACA,OR6S1,OR4S1,ADCY3,OR5V1,SLC8A3,OR52E2,OR4Q3,OR2AP1,OR10G9,OR5AP2,OR6K6,OR5H15,OR13C9,ARRB1,OR8G2P,OR52E8,OR51A2,CNGB1,OR6C1,OR13C3,OR10H5,OR1N2,OR2AG2,OR4K2,OR4K1,OR1L3,OR13C8,OR5B17,OR1L4,OR2T27,OR5T3,OR52M1,OR4D2,OR5H1,OR2AT4,OR51V1,OR2K2,OR8B8,OR2G2,OR1D5,OR2T1,OR11G2,OR52N5,OR2D2,OR1L6,OR2F2,CALML4,OR5M1,CAMK2D,ANO2,OR9A4,OR8K5,SLC24A4,OR2H2,PDE1C,OR1S1,OR2L2,OR5AN1,OR10A7,OR2T2,OR10C1,OR5B12,OR6K3,OR5K4,CALML3,CALM3,PRKACB,OR12D2,OR10H1,OR5A2,OR10P1,OR6V1,OR8B2,GNAL,OR4D5,OR6B2,CALM2,GRK3,SLC8A1,OR6C65,OR10T2,OR1J1,OR4E2,OR52B2,OR10J1,OR8D1